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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CLASP2-GLB1 (FusionGDB2 ID:HG23122TG2720)

Fusion Gene Summary for CLASP2-GLB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CLASP2-GLB1
Fusion gene ID: hg23122tg2720
HgeneTgene
Gene symbol

CLASP2

GLB1

Gene ID

23122

2720

Gene namecytoplasmic linker associated protein 2galactosidase beta 1
Synonyms-EBP|ELNR1|MPS4B
Cytomap('CLASP2')('GLB1')

3p22.3

3p22.3

Type of geneprotein-codingprotein-coding
DescriptionCLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2beta-galactosidaseacid beta-galactosidaseelastin binding proteinelastin receptor 1, 67kDalactase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000313350, ENST00000333778, 
ENST00000359576, ENST00000399362, 
ENST00000461133, ENST00000468888, 
ENST00000480013, ENST00000487200, 
ENST00000307312, ENST00000482896, 
ENST00000539981, 
Fusion gene scores* DoF score9 X 9 X 6=4869 X 9 X 5=405
# samples 99
** MAII scorelog2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CLASP2 [Title/Abstract] AND GLB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCLASP2(33673784)-GLB1(33114205), # samples:1
Anticipated loss of major functional domain due to fusion event.CLASP2-GLB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CLASP2-GLB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGLB1

GO:0044262

cellular carbohydrate metabolic process

11927518


check buttonFusion gene breakpoints across CLASP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GLB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DG-A2KL-01ACLASP2chr3

33673784

-GLB1chr3

33114205

-


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Fusion Gene ORF analysis for CLASP2-GLB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000313350ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000313350ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000313350ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000333778ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000333778ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000333778ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000359576ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000359576ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000359576ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000399362ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000399362ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000399362ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000461133ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000461133ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000461133ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000468888ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000468888ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000468888ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000480013ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000480013ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000480013ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000487200ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000487200ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-5UTRENST00000487200ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000313350ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000333778ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000359576ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000399362ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000461133ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000468888ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000480013ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5CDS-intronENST00000487200ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-3CDSENST00000307312ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-3CDSENST00000482896ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000307312ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000307312ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000307312ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000482896ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000482896ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-5UTRENST00000482896ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-intronENST00000307312ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
5UTR-intronENST00000482896ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000313350ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000333778ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000359576ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000399362ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000461133ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000468888ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000480013ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
In-frameENST00000487200ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
intron-3CDSENST00000539981ENST00000307363CLASP2chr3

33673784

-GLB1chr3

33114205

-
intron-5UTRENST00000539981ENST00000307377CLASP2chr3

33673784

-GLB1chr3

33114205

-
intron-5UTRENST00000539981ENST00000399402CLASP2chr3

33673784

-GLB1chr3

33114205

-
intron-5UTRENST00000539981ENST00000445488CLASP2chr3

33673784

-GLB1chr3

33114205

-
intron-intronENST00000539981ENST00000497796CLASP2chr3

33673784

-GLB1chr3

33114205

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000468888CLASP2chr333673784-ENST00000307363GLB1chr333114205-338899252950981
ENST00000399362CLASP2chr333673784-ENST00000307363GLB1chr333114205-369212962913254987
ENST00000359576CLASP2chr333673784-ENST00000307363GLB1chr333114205-369212962913254987
ENST00000480013CLASP2chr333673784-ENST00000307363GLB1chr333114205-30916952752653792
ENST00000461133CLASP2chr333673784-ENST00000307363GLB1chr333114205-2755359232317764
ENST00000313350CLASP2chr333673784-ENST00000307363GLB1chr333114205-28344381772396739
ENST00000487200CLASP2chr333673784-ENST00000307363GLB1chr333114205-28454491882407739
ENST00000333778CLASP2chr333673784-ENST00000307363GLB1chr333114205-28954992262457743

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000468888ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0004728910.9995271
ENST00000399362ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0005389580.999461
ENST00000359576ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0005389580.999461
ENST00000480013ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0031114160.9968886
ENST00000461133ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0025606030.9974394
ENST00000313350ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0021544740.99784553
ENST00000487200ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0021034750.99789655
ENST00000333778ENST00000307363CLASP2chr333673784-GLB1chr333114205-0.0016003890.99839956

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Fusion Genomic Features for CLASP2-GLB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CLASP2-GLB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:33673784/chr3:33114205)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-3131104_110887432.0Compositional biasNote=Poly-Leu
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313310_58787432.0Compositional biasNote=Ser-rich
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-3131017_129487432.0RegionNote=Required for cortical localization
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-31360_31187432.0RegionTOG 1
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313649_88187432.0RegionTOG 2
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-3131054_109187432.0RepeatHEAT 6
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-3131098_113587432.0RepeatHEAT 7
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-3131216_125387432.0RepeatHEAT 8
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313173_20887432.0RepeatHEAT 1
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313209_24587432.0RepeatHEAT 2
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313250_28787432.0RepeatHEAT 3
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313710_74787432.0RepeatHEAT 4
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313772_80987432.0RepeatHEAT 5


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Fusion Gene Sequence for CLASP2-GLB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16943_16943_1_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000313350_GLB1_chr3_33114205_ENST00000307363_length(transcript)=2834nt_BP=438nt
ACAGCACCTAGGGCAGGGAAGAGAAAGAAAAATGCCGGCACAAACCTCAGTGGTGGTTCTGTGGTTGTTTCTGTCTTTTTTTGATAGAAT
CTTTGATTAGTATCGAATTTACTGTATTTGGCCATGTGAACTATTGGGAGCCTCCTAGGGTGAGGGAAATTAAGAGCTTTCAGAGGAATG
AGGCGACTGATTTGCAAACGGATCTGTGATTATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCA
GCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGT
GCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGAATGCCACCCAG
AGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGT
GTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCAT
GAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATC
CTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCC
TCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCA
GTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCAC
CATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACG
GTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTC
TATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGT
GGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACC
AGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAA
GTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTG
GACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGG
ACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGG
ATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAAC
ATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGG
ACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGG
GCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACC
TTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTG
ACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGAT
GATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAA
AGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACC
CTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCA
CCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGC
ATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAAT
TTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTG
AATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAATA

>16943_16943_1_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000313350_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=739AA_BP=0
MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQNAT
QRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLV
ILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFR
HHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILA
RGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAA
LDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVE
NMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQD
TFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVE
KRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_2_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000333778_GLB1_chr3_33114205_ENST00000307363_length(transcript)=2895nt_BP=499nt
GCAGAATCTGGGTATAAGGAATAAGGCAGGGCGTGCTAGAAGATACACTATGGGAGGAGCTGGCAGAAAATGCAGAGTAGCAAAAACATG
AAAAATACTTTTACTACCTTTAGAGTTAAAATGTTTTATGTTTTGACTTAATATGTATAAGTAAGAAGTATGAAAATACTGCATTTTGAT
TTTGAATTACAGAGGATTATTTTATATGGTGTTAGCCAATATATAAATGCTTATTCAAAGGACCTTTATTTCGTATTATATATCTTACCA
AAATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATC
CGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGT
TGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGA
CTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCT
GCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTC
TGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGA
GTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGA
CAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATA
TGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTAC
CACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCAC
AGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCA
ACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTAT
AGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGA
GGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTAC
ACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAA
AAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCC
AGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAA
TGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATAT
CAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGC
AGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCC
GGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGG
CCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGAT
GACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGT
GGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAA
CAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTC
ATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGC
CAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGC
TTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTT
TAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCA
AAAGGATGGAAAATA

>16943_16943_2_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000333778_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=743AA_BP=0
MLIQRTFISYYISYQNKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSI
QNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHEL
GLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQ
KRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLY
DILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKT
VGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLD
LLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPD
LPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPS
KPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_3_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000359576_GLB1_chr3_33114205_ENST00000307363_length(transcript)=3692nt_BP=1296nt
AGAGGTCCTATCGCTCCCAGCGGTTTCCGCAGCCACCTCCACCACCTCCGCAGCAAAACGCTAGCCGGACTGGAGGGCCCTCGCCGGCGT
CGTGCTGACGTCACGCGCGTGCTGACGTCGCCCGCGGCCGCGGCCTCTGAAGCGGGCTGGGGATCGGGGGGCGCCGAGTTTGACTAGTTT
GGGGGCGGCTGGGCGCTTGGCGTTCCTCCCGCCGCCCGCTGCGCCCCGCAAGCCGCGCCCCTGGCGGGCTAAGTGAGTCCCGCCCGCTCC
CGCGGGGACCCGCACTGGAGGCTGGGCGGCTCTCGGCGAAAGTTGGCCGCTCACAGACTGGCAGGCGGGCGGGCGGCCGCAGCCATGGAG
CCCCGCAGCATGGAGTACTTCTGCGCCCAGGTGCAGCAGAAGGACGTCGGCGGCCGGCTGCAGGTCGGCCAGGAGCTCCTGCTCTACCTT
GGCGCCCCCGGCGCCATCTCGGACCTGGAGGAGGACCTGGGCCGCCTAGGCAAGACAGTCGACGCGCTCACCGGCTGGGTGGGTTCGAGC
AACTACCGGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCTATGTAGCAATGGTT
ATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGTTAATGGATCAAGTA
GCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGTGTCTGTGTCTTATT
GAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAGACTCCAACAGTCAG
GTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATAAGAGAGGAATTCCC
CCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCAAAGATAAAAGCTTC
GATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCC
AACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGAT
TTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAG
GATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAG
ATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGAT
GTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGA
GGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGA
GTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTT
GCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCA
CATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTA
AGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACA
ATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAAT
TTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTC
ACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCA
TATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCC
TTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCT
TCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTG
AACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAG
GGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCAC
CTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATG
GGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATT
AATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCA
AACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTT
ATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGG
CTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCA
CTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCT
TCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTA
GTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTA
TTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAA
TA

>16943_16943_3_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000359576_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=987AA_BP=1
MGGSRRKLAAHRLAGGRAAAAMEPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRVSLM
GLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFG
AQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRMDLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVD
GNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQNATQRMFEIDYSRDSFLKDGQPFRY
ISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKC
GALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGA
NSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVK
QHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLT
LSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGR
YWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_4_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000399362_GLB1_chr3_33114205_ENST00000307363_length(transcript)=3692nt_BP=1296nt
AGAGGTCCTATCGCTCCCAGCGGTTTCCGCAGCCACCTCCACCACCTCCGCAGCAAAACGCTAGCCGGACTGGAGGGCCCTCGCCGGCGT
CGTGCTGACGTCACGCGCGTGCTGACGTCGCCCGCGGCCGCGGCCTCTGAAGCGGGCTGGGGATCGGGGGGCGCCGAGTTTGACTAGTTT
GGGGGCGGCTGGGCGCTTGGCGTTCCTCCCGCCGCCCGCTGCGCCCCGCAAGCCGCGCCCCTGGCGGGCTAAGTGAGTCCCGCCCGCTCC
CGCGGGGACCCGCACTGGAGGCTGGGCGGCTCTCGGCGAAAGTTGGCCGCTCACAGACTGGCAGGCGGGCGGGCGGCCGCAGCCATGGAG
CCCCGCAGCATGGAGTACTTCTGCGCCCAGGTGCAGCAGAAGGACGTCGGCGGCCGGCTGCAGGTCGGCCAGGAGCTCCTGCTCTACCTT
GGCGCCCCCGGCGCCATCTCGGACCTGGAGGAGGACCTGGGCCGCCTAGGCAAGACAGTCGACGCGCTCACCGGCTGGGTGGGTTCGAGC
AACTACCGGGTATCATTAATGGGATTGGAAATTTTAAGTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCTATGTAGCAATGGTT
ATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAGACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGTTAATGGATCAAGTA
GCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTGGTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGTGTCTGTGTCTTATT
GAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCATCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAGACTCCAACAGTCAG
GTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTTATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATAAGAGAGGAATTCCC
CCTGCTAGATTAGAAATGATATTTGCCAAATTTGATGAAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCAAAGATAAAAGCTTC
GATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCC
AACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGAT
TTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAG
GATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAG
ATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGAT
GTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGA
GGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGA
GTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTT
GCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCA
CATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTA
AGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACA
ATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAAT
TTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTC
ACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCA
TATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCC
TTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCT
TCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTG
AACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAG
GGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCAC
CTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATG
GGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATT
AATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCA
AACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTT
ATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGG
CTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCA
CTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCT
TCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTA
GTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTA
TTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAA
TA

>16943_16943_4_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000399362_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=987AA_BP=1
MGGSRRKLAAHRLAGGRAAAAMEPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRVSLM
GLEILSAFVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFG
AQPLVISKLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRMDLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVD
GNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQNATQRMFEIDYSRDSFLKDGQPFRY
ISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLL
EKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKC
GALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGA
NSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVK
QHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLT
LSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGR
YWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_5_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000461133_GLB1_chr3_33114205_ENST00000307363_length(transcript)=2755nt_BP=359nt
ACAGTGCTCCGGGTGTCTGCAGGCTGCAGGCCGAGCCCAGTGGCGCAGGCACTGAGCTGTACTTATTTGCTGTGCTATTTGACCTCTTGG
TTTCAGAGAGCTCCCTGGACCATCTAATGGCTATGGGAGATGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCAT
CAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTA
AGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGA
ATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTC
ACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCT
GGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGAC
TGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTC
TTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGA
ATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGC
GCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCC
TCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCA
ATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATA
TACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAG
CACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGA
AGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGG
GAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTG
TGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTG
CTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTC
TGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCC
TCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATG
ATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGC
CCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGG
GCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCT
GCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAAC
CTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGA
GGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGAT
GTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCA
CAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTG
TTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACT
TGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAATA

>16943_16943_5_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000461133_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=764AA_BP=1
MQAEPSGAGTELYLFAVLFDLLVSESSLDHLMAMGDDKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKE
GGAGAVDEDDFIKAFTDVPSIQNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWP
GQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITV
QVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGW
LDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEG
PIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQG
VLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNS
SNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPEL
CAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_6_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000468888_GLB1_chr3_33114205_ENST00000307363_length(transcript)=3388nt_BP=992nt
GAAAGTTGGCCGCTCACAGACTGGCAGGCGGGCGGGCGGCCGCAGCCATGGAGCCCCGCAGCATGGAGTACTTCTGCGCCCAGGTGCAGC
AGAAGGACGTCGGCGGCCGGCTGCAGGTCGGCCAGGAGCTCCTGCTCTACCTTGGCGCCCCCGGCGCCATCTCGGACCTGGAGGAGGACC
TGGGCCGCCTAGGCAAGACAGTCGACGCGCTCACCGGCTGGGTGGGTTCGAGCAACTACCGGGTATCATTAATGGGATTGGAAATTTTAA
GTGCCTTTGTGGACAGATTATCAACACGCTTTAAATCCTATGTAGCAATGGTTATTGTAGCTTTAATAGACAGAATGGGAGATGCCAAAG
ACAAGGTTCGAGATGAAGCTCAGACTCTGATATTGAAGTTAATGGATCAAGTAGCACCACCTATGTACATTTGGGAGCAGTTGGCTTCTG
GTTTTAAACACAAGAATTTTCGATCTCGAGAAGGCGTGTGTCTGTGTCTTATTGAAACCTTAAACATTTTTGGGGCTCAGCCACTAGTCA
TCAGCAAATTGATACCACATTTGTGTATCCTGTTTGGAGACTCCAACAGTCAGGTGAGAGATGCTGCAATATTGGCTATAGTGGAGATTT
ATAGACATGTGGGAGAAAAAGTGAGGATGGATCTTTATAAGAGAGGAATTCCCCCTGCTAGATTAGAAATGATATTTGCCAAATTTGATG
AAGTGCAAAGTTCAGGCGGTATGATTTTGAGTGTCTGCAAAGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCAT
CAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTA
AGGTTGGAGCAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTC
AGAATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCA
TTCACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGC
CCTGGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGG
GACTGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTA
TTCTTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATC
AGAATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGA
AGCGCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGG
GCCTCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGA
TCAATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATG
ATATACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATG
CAGCACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCC
AGAAGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAG
TGGGAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGT
TTGTGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATG
TTGCTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACC
TTCTGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATA
TCCTCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACC
ATGATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACT
TGCCCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCC
GGGGCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCAC
CCTGCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCA
AACCTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTT
TGAGGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAG
GATGTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACA
GCACAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTT
TTGTTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAG
ACTTGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAATA

>16943_16943_6_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000468888_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=981AA_BP=1
MAAHRLAGGRAAAAMEPRSMEYFCAQVQQKDVGGRLQVGQELLLYLGAPGAISDLEEDLGRLGKTVDALTGWVGSSNYRVSLMGLEILSA
FVDRLSTRFKSYVAMVIVALIDRMGDAKDKVRDEAQTLILKLMDQVAPPMYIWEQLASGFKHKNFRSREGVCLCLIETLNIFGAQPLVIS
KLIPHLCILFGDSNSQVRDAAILAIVEIYRHVGEKVRMDLYKRGIPPARLEMIFAKFDEVQSSGGMILSVCKDKSFDDEESVDGNRPSSA
ASAFKVPAPKTSGNPANSARKPGSAGGPKVGAGASKEGGAGAVDEDDFIKAFTDVPSIQNATQRMFEIDYSRDSFLKDGQPFRYISGSIH
YSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESIL
LRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGL
YTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAA
QPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFV
LYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNIL
TDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARG
PQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_7_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000480013_GLB1_chr3_33114205_ENST00000307363_length(transcript)=3091nt_BP=695nt
ATTGCTACTGATTACATGGATATCTTTAGGGAAGCAGAAAATGATTGCTGAACACATGCCTTGTGTTTTGATGATTGCATTAAAAGTCCC
CCAGCGGGATGGCATTTATTGGCTCTCAGAGCTTTTCTTAGATTAAATTTCAGGCAGCCAGTACAAGGAGAAACATCATAACCTGTATCC
AACAGCATATGTGCAGCTAAAGAGTAATCTTAATCAAGTCCTTCTAGGCTGTGCTAAATAAACGAGGGTTTTCAGCAAGACCCCAGACTT
TTATTTTGAAGTGGAGTAGCAGCTGTTGGCTATTGCGGTGCAGAGCTGCAGCGAGGCCTGGGTCACACAGTGCTCCGGGTGTCTGCAGGC
TGCAGGCCGAGCCCAGTGGCGCAGGCACTGAGCTGTACTTATTTGCTGTGCTATTTGACCTCTTGGTTTCAGAGAGCTCCCTGGACCATC
TAATGGCTATGGGAGATGATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCATCAGCTGCATCAGCCTTCAAGGTTC
CTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTAAGGTTGGAGGTGCTTCTAAGGAAG
GAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGAATGCCACCCAGAGGATGTTTGAAA
TTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTCACTACTCCCGTGTGCCCCGCTTCT
ACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCTGGAACTTTCATGAGCCCTGGCCAG
GACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGACTGCTGGTTATCCTGAGGCCCGGGC
CCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTCTTCTCCGCTCCTCCGACCCAGATT
ACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGAATGGAGGGCCAGTTATAACAGTGC
AGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGCGCTTTCGCCACCATCTGGGGGATG
ATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCCTCTACACCACGGTGGACTTTGGAA
CAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCAATTCTGAATTCTATACTGGCTGGC
TAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATATACTTGCCCGTGGGGCGAGTGTGA
ACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAGCACAGCCCACCAGCTACGACTATG
ATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGAAGTTTGAAAAAGTACCAGAAGGTC
CTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGGGAGCAGCTCTGGACATTCTGTGTC
CCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTGTGCTGTACCGGACAACACTTCCTC
AAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTGCTGTGGATGGGATCCCCCAGGGAG
TCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTCTGGTAGAGAACATGGGACGTGTGA
ACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCCTCACGGACTGGACGATCTTTCCAC
TGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATGATGAAGCCTGGGCCCACAACTCAT
CCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGCCCCAGGACACCTTTATCCAGTTTC
CTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGGGCCCTCAGTTGACCTTGTTTGTGC
CCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCTGCAGCAGTGATGATCCAGAACTAT
GTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAACCTGTTGAAAAAAGACTCATGCCCC
CACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGAGGGATTCTACCCTGAACATACCTC
ACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGATGTGCATTTTCACCTGAGGTTTCCC
TGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCACAGTAACGTGCATACATATCTGCA
GGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTGTTAAATAAAATTTGTACTCAAATG
ATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACTTGAGTGGGCTGAATAAACCACTTC
ACTAACTTGAAGTTCAAAAGGATGGAAAATA

>16943_16943_7_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000480013_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=792AA_BP=1
MKWSSSCWLLRCRAAARPGSHSAPGVCRLQAEPSGAGTELYLFAVLFDLLVSESSLDHLMAMGDDKSFDDEESVDGNRPSSAASAFKVPA
PKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQNATQRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYW
KDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLVILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYL
AAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFRHHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTG
SNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILARGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDA
PLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAALDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQD
CSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVENMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLD
TEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQDTFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQ
HILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVEKRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------
>16943_16943_8_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000487200_GLB1_chr3_33114205_ENST00000307363_length(transcript)=2845nt_BP=449nt
GATTGGCTGTTACAGCACCTAGGGCAGGGAAGAGAAAGAAAAATGCCGGCACAAACCTCAGTGGTGGTTCTGTGGTTGTTTCTGTCTTTT
TTTGATAGAATCTTTGATTAGTATCGAATTTACTGTATTTGGCCATGTGAACTATTGGGAGCCTCCTAGGGTGAGGGAAATTAAGAGCTT
TCAGAGGAATGAGGCGACTGATTTGCAAACGGATCTGTGATTATAAAAGCTTCGATGATGAAGAATCAGTGGATGGAAATAGGCCATCAT
CAGCTGCATCAGCCTTCAAGGTTCCTGCACCTAAAACATCCGGAAATCCTGCCAACAGTGCAAGGAAGCCTGGTTCAGCAGGTGGCCCTA
AGGTTGGAGGTGCTTCTAAGGAAGGAGGTGCTGGAGCAGTTGATGAAGATGATTTTATAAAAGCTTTTACAGATGTCCCTTCTATTCAGA
ATGCCACCCAGAGGATGTTTGAAATTGACTATAGCCGGGACTCCTTCCTCAAGGATGGCCAGCCATTTCGCTACATCTCAGGAAGCATTC
ACTACTCCCGTGTGCCCCGCTTCTACTGGAAGGACCGGCTGCTGAAGATGAAGATGGCTGGGCTGAACGCCATCCAGACGTATGTGCCCT
GGAACTTTCATGAGCCCTGGCCAGGACAGTACCAGTTTTCTGAGGACCATGATGTGGAATATTTTCTTCGGCTGGCTCATGAGCTGGGAC
TGCTGGTTATCCTGAGGCCCGGGCCCTACATCTGTGCAGAGTGGGAAATGGGAGGATTACCTGCTTGGCTGCTAGAGAAAGAGTCTATTC
TTCTCCGCTCCTCCGACCCAGATTACCTGGCAGCTGTGGACAAGTGGTTGGGAGTCCTTCTGCCCAAGATGAAGCCTCTCCTCTATCAGA
ATGGAGGGCCAGTTATAACAGTGCAGGTTGAAAATGAATATGGCAGCTACTTTGCCTGTGATTTTGACTACCTGCGCTTCCTGCAGAAGC
GCTTTCGCCACCATCTGGGGGATGATGTGGTTCTGTTTACCACTGATGGAGCACATAAAACATTCCTGAAATGTGGGGCCCTGCAGGGCC
TCTACACCACGGTGGACTTTGGAACAGGCAGCAACATCACAGATGCTTTCCTAAGCCAGAGGAAGTGTGAGCCCAAAGGACCCTTGATCA
ATTCTGAATTCTATACTGGCTGGCTAGATCACTGGGGCCAACCTCACTCCACAATCAAGACCGAAGCAGTGGCTTCCTCCCTCTATGATA
TACTTGCCCGTGGGGCGAGTGTGAACTTGTACATGTTTATAGGTGGGACCAATTTTGCCTATTGGAATGGGGCCAACTCACCCTATGCAG
CACAGCCCACCAGCTACGACTATGATGCCCCACTGAGTGAGGCTGGGGACCTCACTGAGAAGTATTTTGCTCTGCGAAACATCATCCAGA
AGTTTGAAAAAGTACCAGAAGGTCCTATCCCTCCATCTACACCAAAGTTTGCATATGGAAAGGTCACTTTGGAAAAGTTAAAGACAGTGG
GAGCAGCTCTGGACATTCTGTGTCCCTCTGGGCCCATCAAAAGCCTTTATCCCTTGACATTTATCCAGGTGAAACAGCATTATGGGTTTG
TGCTGTACCGGACAACACTTCCTCAAGATTGCAGCAACCCAGCACCTCTCTCTTCACCCCTCAATGGAGTCCACGATCGAGCATATGTTG
CTGTGGATGGGATCCCCCAGGGAGTCCTTGAGCGAAACAATGTGATCACTCTGAACATAACAGGGAAAGCTGGAGCCACTCTGGACCTTC
TGGTAGAGAACATGGGACGTGTGAACTATGGTGCATATATCAACGATTTTAAGGGTTTGGTTTCTAACCTGACTCTCAGTTCCAATATCC
TCACGGACTGGACGATCTTTCCACTGGACACTGAGGATGCAGTGTGCAGCCACCTGGGGGGCTGGGGACACCGTGACAGTGGCCACCATG
ATGAAGCCTGGGCCCACAACTCATCCAACTACACGCTCCCGGCCTTTTATATGGGGAACTTCTCCATTCCCAGTGGGATCCCAGACTTGC
CCCAGGACACCTTTATCCAGTTTCCTGGATGGACCAAGGGCCAGGTCTGGATTAATGGCTTTAACCTTGGCCGCTATTGGCCAGCCCGGG
GCCCTCAGTTGACCTTGTTTGTGCCCCAGCACATCCTGATGACCTCGGCCCCAAACACCATCACCGTGCTGGAACTGGAGTGGGCACCCT
GCAGCAGTGATGATCCAGAACTATGTGCTGTGACGTTCGTGGACAGGCCAGTTATTGGCTCATCTGTGACCTACGATCATCCCTCCAAAC
CTGTTGAAAAAAGACTCATGCCCCCACCCCCGCAAAAAAACAAAGATTCATGGCTGGACCATGTATGATGATGAAAGCCTGTGTCTTTGA
GGGATTCTACCCTGAACATACCTCACAGATCCTCCCTGTCATGCCACATTTCACTGATTGGAATGTGGAAATGGAAAAGGAATTTAGGAT
GTGCATTTTCACCTGAGGTTTCCCTGCATCCCTGCAGTGCCAAAGCCCCACCTTCAGGGACCACCTGGAATGTGTGAGGGGCTGACAGCA
CAGTAACGTGCATACATATCTGCAGGGCTGGAATGGAAGCTTTAAAGGTGGTAGTGATTTTTATTTTGGAAGAATCATGTTACCTTTTTG
TTAAATAAAATTTGTACTCAAATGATGATGTCACTGTTTTTAATGTGCAGGTATTGAATTATATGGTCTGACTTAAATCATAACTAGACT
TGAGTGGGCTGAATAAACCACTTCACTAACTTGAAGTTCAAAAGGATGGAAAATA

>16943_16943_8_CLASP2-GLB1_CLASP2_chr3_33673784_ENST00000487200_GLB1_chr3_33114205_ENST00000307363_length(amino acids)=739AA_BP=0
MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTSGNPANSARKPGSAGGPKVGGASKEGGAGAVDEDDFIKAFTDVPSIQNAT
QRMFEIDYSRDSFLKDGQPFRYISGSIHYSRVPRFYWKDRLLKMKMAGLNAIQTYVPWNFHEPWPGQYQFSEDHDVEYFLRLAHELGLLV
ILRPGPYICAEWEMGGLPAWLLEKESILLRSSDPDYLAAVDKWLGVLLPKMKPLLYQNGGPVITVQVENEYGSYFACDFDYLRFLQKRFR
HHLGDDVVLFTTDGAHKTFLKCGALQGLYTTVDFGTGSNITDAFLSQRKCEPKGPLINSEFYTGWLDHWGQPHSTIKTEAVASSLYDILA
RGASVNLYMFIGGTNFAYWNGANSPYAAQPTSYDYDAPLSEAGDLTEKYFALRNIIQKFEKVPEGPIPPSTPKFAYGKVTLEKLKTVGAA
LDILCPSGPIKSLYPLTFIQVKQHYGFVLYRTTLPQDCSNPAPLSSPLNGVHDRAYVAVDGIPQGVLERNNVITLNITGKAGATLDLLVE
NMGRVNYGAYINDFKGLVSNLTLSSNILTDWTIFPLDTEDAVCSHLGGWGHRDSGHHDEAWAHNSSNYTLPAFYMGNFSIPSGIPDLPQD
TFIQFPGWTKGQVWINGFNLGRYWPARGPQLTLFVPQHILMTSAPNTITVLELEWAPCSSDDPELCAVTFVDRPVIGSSVTYDHPSKPVE
KRLMPPPPQKNKDSWLDHV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CLASP2-GLB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313444_58087.0432.0microtubules%2C MAPRE1 and MAPRE3
HgeneCLASP2chr3:33673784chr3:33114205ENST00000313350-313872_129487.0432.0RSN and localization to the Golgi and kinetochores


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CLASP2-GLB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CLASP2-GLB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0268271Gangliosidosis, Generalized GM1, Type 1 (disorder)21CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0268272Gangliosidosis, Generalized GM1, Type 214CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0268273Gangliosidosis, Generalized GM1, Type 313CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0086652Mucopolysaccharidosis type IVB12CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0026707Mucopolysaccharidosis IV4CTD_human;GENOMICS_ENGLAND
TgeneC0086651Mucopolysaccharidosis, MPS-IV-A2CTD_human
TgeneC3179194GALNS Deficiency2CTD_human
TgeneC0005941Bone Diseases, Developmental1CTD_human
TgeneC0010038Corneal Opacity1CTD_human
TgeneC0011615Dermatitis, Atopic1CTD_human
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0013366Dyschondroplasias1CTD_human
TgeneC0025237Melnick-Needles Syndrome1CTD_human
TgeneC0026760Multiple Epiphyseal Dysplasia1CTD_human
TgeneC0029422Osteochondrodysplasias1CTD_human
TgeneC0036391Schwartz-Jampel Syndrome1CTD_human
TgeneC0036572Seizures1GENOMICS_ENGLAND
TgeneC0038015Spondyloepiphyseal Dysplasia1CTD_human
TgeneC0086196Eczema, Infantile1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC0432272Van Buchem disease1CTD_human
TgeneC3541456Spondyloepiphyseal Dysplasia Tarda, X-Linked1CTD_human
TgeneC4551479Schwartz-Jampel Syndrome, Type 11CTD_human