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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:ATG2A-KLK10 (FusionGDB2 ID:HG23130TG5655) |
Fusion Gene Summary for ATG2A-KLK10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATG2A-KLK10 | Fusion gene ID: hg23130tg5655 | Hgene | Tgene | Gene symbol | ATG2A | KLK10 | Gene ID | 23130 | 5655 |
| Gene name | autophagy related 2A | kallikrein related peptidase 10 | |
| Synonyms | - | NES1|PRSSL1 | |
| Cytomap | ('ATG2A')('KLK10') 11q13.1 | 19q13.41 | |
| Type of gene | protein-coding | protein-coding | |
| Description | autophagy-related protein 2 homolog AATG2 autophagy related 2 homolog A | kallikrein-10breast normal epithelial cell associated serine proteasekallikrein 10 protein 1kallikrein 10 protein 12kallikrein 10 protein 13kallikrein 10 protein 2kallikrein 10 protein 3kallikrein 10 protein 4kallikrein 10 protein 5kallikrein 10 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000377264, ENST00000421419, | ||
| Fusion gene scores | * DoF score | 7 X 10 X 7=490 | 7 X 6 X 3=126 |
| # samples | 8 | 8 | |
| ** MAII score | log2(8/490*10)=-2.61470984411521 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/126*10)=-0.655351828612554 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATG2A [Title/Abstract] AND KLK10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | ATG2A(64673034)-KLK10(51519412), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | ATG2A-KLK10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ATG2A-KLK10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across ATG2A (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across KLK10 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-13-0913 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
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Fusion Gene ORF analysis for ATG2A-KLK10 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000377264 | ENST00000309958 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| In-frame | ENST00000377264 | ENST00000358789 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| In-frame | ENST00000377264 | ENST00000391805 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| In-frame | ENST00000421419 | ENST00000309958 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| In-frame | ENST00000421419 | ENST00000358789 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| In-frame | ENST00000421419 | ENST00000391805 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000421419 | ATG2A | chr11 | 64673034 | - | ENST00000309958 | KLK10 | chr19 | 51519412 | - | 6202 | 3579 | 115 | 4140 | 1341 |
| ENST00000421419 | ATG2A | chr11 | 64673034 | - | ENST00000391805 | KLK10 | chr19 | 51519412 | - | 6196 | 3579 | 115 | 4140 | 1341 |
| ENST00000421419 | ATG2A | chr11 | 64673034 | - | ENST00000358789 | KLK10 | chr19 | 51519412 | - | 4671 | 3579 | 115 | 4140 | 1341 |
| ENST00000377264 | ATG2A | chr11 | 64673034 | - | ENST00000309958 | KLK10 | chr19 | 51519412 | - | 6200 | 3577 | 113 | 4138 | 1341 |
| ENST00000377264 | ATG2A | chr11 | 64673034 | - | ENST00000391805 | KLK10 | chr19 | 51519412 | - | 6194 | 3577 | 113 | 4138 | 1341 |
| ENST00000377264 | ATG2A | chr11 | 64673034 | - | ENST00000358789 | KLK10 | chr19 | 51519412 | - | 4669 | 3577 | 113 | 4138 | 1341 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000421419 | ENST00000309958 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.002526491 | 0.99747354 |
| ENST00000421419 | ENST00000391805 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.002523082 | 0.9974769 |
| ENST00000421419 | ENST00000358789 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.004255569 | 0.9957444 |
| ENST00000377264 | ENST00000309958 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.002518487 | 0.9974815 |
| ENST00000377264 | ENST00000391805 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.002514966 | 0.99748504 |
| ENST00000377264 | ENST00000358789 | ATG2A | chr11 | 64673034 | - | KLK10 | chr19 | 51519412 | - | 0.004246163 | 0.9957539 |
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Fusion Genomic Features for ATG2A-KLK10 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for ATG2A-KLK10 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64673034/chr19:51519412) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | KLK10 | chr11:64673034 | chr19:51519412 | ENST00000309958 | 2 | 6 | 47_274 | 89 | 277.0 | Domain | Peptidase S1 | |
| Tgene | KLK10 | chr11:64673034 | chr19:51519412 | ENST00000358789 | 2 | 6 | 47_274 | 89 | 277.0 | Domain | Peptidase S1 | |
| Tgene | KLK10 | chr11:64673034 | chr19:51519412 | ENST00000391805 | 2 | 6 | 47_274 | 89 | 277.0 | Domain | Peptidase S1 |
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Fusion Gene Sequence for ATG2A-KLK10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >7544_7544_1_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000309958_length(transcript)=6200nt_BP=3577nt CTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGGCG GCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCACC ACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACATCC ACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGTGG CCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGCGC CAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGAGC CCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCTGG ACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGATG AGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGTCC GCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGATGG TGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAGGC AGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCTAG GTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCTTA CCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCTCT CCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGATGG CCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTCTG CCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTTCC ATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCGGA CGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTCTG AGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACAGA TCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCAGG CGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGACAG AGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCTGC GGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCTTA GCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACCTG TCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCCCC AGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACCTG AGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCAGA GCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAGCA TCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTTCC CCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTCGG ACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTTGC AGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGAGG CTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTTCT GTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGCTC CCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGGAC CCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGCCA CCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGGCT ACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGTCC TCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGGGG ATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCA TCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGC TTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCC TGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGAC TGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTT ACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGAT CCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGT CGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCT ATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCA GCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTG AACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATG TAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCACGT CCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGTAGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAGAA TCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCTTTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCACC CAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATTAGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACCTT GCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGTAGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCAAG AAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGTCTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAGGA ATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAGTTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCTGG GTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGCCA AAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTAGCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTGAG GCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCAAA ACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCTTATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACAAC AGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTTTGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCCAG TGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGTCCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCACA CAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATTAGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATCCA AAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGATTCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTTTA TCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGACCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCCAG TCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCACCTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTTTT GGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTTTTTTTTTTTAATAGCACCTATTATACCTGAAATTATCTCA >7544_7544_1_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000309958_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- >7544_7544_2_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000358789_length(transcript)=4669nt_BP=3577nt CTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGGCG GCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCACC ACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACATCC ACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGTGG CCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGCGC CAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGAGC CCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCTGG ACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGATG AGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGTCC GCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGATGG TGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAGGC AGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCTAG GTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCTTA CCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCTCT CCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGATGG CCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTCTG CCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTTCC ATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCGGA CGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTCTG AGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACAGA TCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCAGG CGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGACAG AGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCTGC GGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCTTA GCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACCTG TCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCCCC AGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACCTG AGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCAGA GCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAGCA TCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTTCC CCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTCGG ACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTTGC AGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGAGG CTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTTCT GTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGCTC CCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGGAC CCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGCCA CCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGGCT ACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGTCC TCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGGGG ATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCA TCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGC TTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCC TGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGAC TGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTT ACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGAT CCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGT CGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCT ATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCA GCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTG AACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATG TAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGA >7544_7544_2_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000358789_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- >7544_7544_3_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000391805_length(transcript)=6194nt_BP=3577nt CTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGGCG GCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCACC ACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACATCC ACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGTGG CCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGCGC CAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGAGC CCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCTGG ACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGATG AGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGTCC GCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGATGG TGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAGGC AGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCTAG GTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCTTA CCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCTCT CCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGATGG CCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTCTG CCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTTCC ATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCGGA CGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTCTG AGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACAGA TCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCAGG CGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGACAG AGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCTGC GGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCTTA GCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACCTG TCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCCCC AGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACCTG AGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCAGA GCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAGCA TCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTTCC CCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTCGG ACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTTGC AGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGAGG CTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTTCT GTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGCTC CCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGGAC CCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGCCA CCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGGCT ACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGTCC TCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGGGG ATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCCCA TCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCAGC TTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGGCC TGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGGAC TGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGTTT ACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTGAT CCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCAGT CGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCACCT ATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACCCA GCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTCTG AACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTATG TAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCACGT CCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGTAGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAGAA TCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCTTTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCACC CAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATTAGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACCTT GCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGTAGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCAAG AAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGTCTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAGGA ATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAGTTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCTGG GTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGCCA AAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTAGCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTGAG GCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCAAA ACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCTTATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACAAC AGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTTTGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCCAG TGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGTCCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCACA CAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATTAGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATCCA AAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGATTCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTTTA TCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGACCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCCAG TCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCACCTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTTTT GGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTTTTTTTTTTTAATAGCACCTATTATACCTGAAATT >7544_7544_3_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000377264_KLK10_chr19_51519412_ENST00000391805_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- >7544_7544_4_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000309958_length(transcript)=6202nt_BP=3579nt GCCTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGG CGGCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCA CCACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACAT CCACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGT GGCCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGC GCCAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGA GCCCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCT GGACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGA TGAGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGT CCGCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGAT GGTGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAG GCAGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCT AGGTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCT TACCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCT CTCCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGAT GGCCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTC TGCCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTT CCATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCG GACGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTC TGAGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACA GATCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCA GGCGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGAC AGAGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCT GCGGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCT TAGCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACC TGTCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCC CCAGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACC TGAGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCA GAGCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAG CATCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTT CCCCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTC GGACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTT GCAGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGA GGCTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTT CTGTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGC TCCCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGG ACCCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGC CACCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGG CTACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGT CCTCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGG GGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCC CATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCA GCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGG CCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGG ACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGT TTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTG ATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCA GTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCAC CTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACC CAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTC TGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTA TGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCAC GTCCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGTAGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAG AATCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCTTTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCA CCCAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATTAGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACC TTGCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGTAGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCA AGAAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGTCTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAG GAATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAGTTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCT GGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGC CAAAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTAGCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTG AGGCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCA AAACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCTTATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACA ACAGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTTTGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCC AGTGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGTCCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCA CACAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATTAGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATC CAAAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGATTCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTT TATCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGACCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCC AGTCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCACCTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTT TTGGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTTTTTTTTTTTAATAGCACCTATTATACCTGAAATTATCTCA >7544_7544_4_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000309958_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- >7544_7544_5_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000358789_length(transcript)=4671nt_BP=3579nt GCCTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGG CGGCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCA CCACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACAT CCACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGT GGCCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGC GCCAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGA GCCCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCT GGACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGA TGAGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGT CCGCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGAT GGTGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAG GCAGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCT AGGTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCT TACCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCT CTCCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGAT GGCCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTC TGCCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTT CCATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCG GACGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTC TGAGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACA GATCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCA GGCGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGAC AGAGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCT GCGGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCT TAGCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACC TGTCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCC CCAGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACC TGAGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCA GAGCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAG CATCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTT CCCCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTC GGACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTT GCAGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGA GGCTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTT CTGTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGC TCCCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGG ACCCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGC CACCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGG CTACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGT CCTCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGG GGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCC CATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCA GCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGG CCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGG ACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGT TTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTG ATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCA GTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCAC CTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACC CAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTC TGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTA TGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGA >7544_7544_5_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000358789_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- >7544_7544_6_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000391805_length(transcript)=6196nt_BP=3579nt GCCTGGCGCCTAGAGAAGCGGCGGGGCGAGCCGGGGGCTCTAGTGAACAGCGGAGCCGGACGGGGATCGCCGGCGGGCGGCAAGCGGAGG CGGCCCAGGCCCGGCGGTCTCCGAGATGTCACGATGGCTGTGGCCATGGTCAAACTGTGTGAAAGAGCGGGTCTGCCGCTACTTGCTGCA CCACTACTTAGGTCACTTCTTCCAAGAGCACCTCAGCCTGGACCAGCTCAGCCTCGATCTGTACAAGGGCAGCGTTGCCCTGCGAGACAT CCACCTGGAAATCTGGTCTGTGAACGAGGTGCTGGAGTCAATGGAGTCACCGCTGGAGCTGGTGGAAGGCTTCGTGGGCTCCATCGAGGT GGCCGTGCCCTGGGCTGCTCTGCTCACCGACCACTGCACAGTGCGCGTGTCCGGCCTCCAGCTCACCTTGCAGCCCCGCCGGGGTCCAGC GCCAGGGGCTGCCGACTCACAGAGCTGGGCCTCATGCATGACCACAAGCCTGCAGCTGGCCCAGGAGTGTCTGCGGGATGGGCTACCGGA GCCCTCTGAGCCACCACAGCCCCTGGAGGGGCTGGAGATGTTTGCCCAGACCATTGAGACTGTGCTTCGGAGGATCAAAGTGACCTTCCT GGACACTGTCGTGAGGGTGGAGCACTCTCCGGGTGATGGGGAACGTGGTGTGGCCGTCGAGGTCCGTGTGCAGAGACTGGAGTACTGTGA TGAGGCAGTGCGGGACCCAAGCCAGGCGCCGCCGGTGGACGTGCATCAGCCGCCTGCCTTCCTGCACAAGCTGCTGCAGCTGGCAGGGGT CCGCCTGCACTACGAGGAGCTCCCGGCACAGGAAGAGCCTCCAGAGCCCCCCTTGCAGATCGGCAGCTGCTCAGGGTACATGGAGCTGAT GGTGAAGTTGAAGCAAAATGAGGCCTTCCCTGGCCCCAAGTTGGAGGTGGCGGGACAGCTGGGCTCCCTGCACCTGCTCCTGACCCCGAG GCAGCTCCAGCAACTTCAGGAACTGCTCAGCGCCGTGAGCCTTACAGACCACGAGGGCCTGGCTGACAAGCTGAACAAGAGCCGCCCGCT AGGTGCCGAAGACCTGTGGCTGATTGAGCAGGACCTGAACCAGCAGCTGCAGGCAGGGGCAGTGGCTGAGCCCCTCAGCCCAGACCCCCT TACCAACCCCCTTCTCAACCTGGATAACACTGACCTCTTCTTCTCCATGGCTGGCCTCACAAGCAGTGTGGCCTCAGCCCTCTCTGAGCT CTCCCTCTCCGATGTAGACCTGGCCTCCTCTGTGCGCAGCGACATGGCCTCCCGCCGGCTCTCTGCCCAGGCCCACCCAGCTGGCAAGAT GGCCCCCAACCCCCTCCTGGACACCATGCGCCCTGACTCGCTGCTGAAGATGACCTTGGGGGGTGTGACCCTGACCTTGCTTCAGACGTC TGCCCCATCTTCCGGACCACCTGACCTCGCCACGCACTTTTTCACCGAGTTTGATGCCACCAAGGATGGGCCCTTCGGTTCCCGAGACTT CCATCACCTTCGACCACGCTTCCAGAGGGCCTGTCCCTGTAGCCATGTTCGGCTAACGGGCACAGCCGTGCAGCTGTCCTGGGAGCTGCG GACGGGCAGTCGGGGCCGGCGGACAACCAGCATGGAAGTGCACTTCGGGCAGCTGGAGGTGCTGGAGTGTCTGTGGCCCCGGGGCACCTC TGAGCCTGAGTACACGGAGATCCTGACCTTTCCTGGTACGCTGGGCTCCCAGGCCTCAGCTCGGCCCTGCGCCCATCTGCGCCACACACA GATCCTGCGCCGTGTGCCTAAGAGCCGACCCCGGCGCTCAGTTGCCTGCCATTGCCACTCAGAACTGGCCCTGGACCTGGCCAACTTCCA GGCGGACGTGGAGCTGGGGGCCCTGGACCGGCTGGCCGCCCTACTGCGCCTGGCCACCGTACCTGCTGAGCCTCCAGCCGGCCTGCTGAC AGAGCCCCTGCCGGCGATGGAGCAGCAGACGGTATTTCGGCTCTCTGCACCCCGGGCCACGCTGCGGCTGCGCTTCCCCATTGCCGACCT GCGGCCTGAGCCGGACCCCTGGGCGGGCCAGGCCGTGCGGGCTGAGCAGCTTCGGCTGGAGCTGAGTGAGCCCCAGTTCCGGTCAGAGCT TAGCAGTGGGCCTGGTCCCCCAGTCCCCACCCACCTGGAACTCACCTGCTCCGACCTACATGGTATCTATGAAGATGGAGGGAAGCCACC TGTCCCTTGCCTGCGTGTCTCCAAAGCCCTGGACCCCAAGAGCACTGGGCGCAAGTACTTCCTGCCCCAGGTAGTGGTGACTGTGAACCC CCAGTCCAGCAGCACACAGTGGGAGGTGGCCCCGGAGAAGGGAGAGGAACTGGAGCTGTCAGTGGAGAGTCCCTGTGAGCTGCGGGAACC TGAGCCCTCGCCCTTCTCCTCTAAGAGGACCATGTATGAGACAGAGGAGATGGTGATCCCTGGAGACCCTGAGGAGATGAGGACGTTCCA GAGCCGGACCCTGGCACTGTCCCGCTGCAGCCTGGAAGTGATCCTGCCCAGTGTCCACATCTTTCTGCCCAGCAAGGAGGTCTACGAGAG CATCTACAACAGGATCAACAACGACCTGCTCATGTGGGAGCCTGCAGATCTGCTTCCCACCCCCGACCCCGCCGCCCAGCCCTCGGGCTT CCCCGGCCCCTCAGGCTTCTGGCACGACAGCTTTAAGATGTGCAAGTCAGCCTTCAAGCTGGCCAACTGCTTTGATCTCACCCCAGACTC GGACTCGGATGACGAGGATGCCCACTTCTTCTCAGTGGGGGCATCAGGTGGCCCACAGGCCGCTGCCCCTGAGGCCCCAAGTCTTCACTT GCAGAGCACCTTCTCTACACTGGTGACAGTGCTGAAGGGGCGGATCACAGCCCTCTGTGAGACCAAGGATGAGGGTGGGAAGCGGCTGGA GGCTGTGCACGGGGAGCTGGTGCTGGACATGGAGCACGGTACCCTCTTCAGCGTCTCCCAGTACTGTGGCCAGCCAGGACTTGGCTACTT CTGTCTGGAAGCTGAAAAGGCAACACTCTACCACCGAGCGGCCGTGGATGACTACCCGCTGCCCAGTCACCTGGACCTTCCCAGTTTCGC TCCCCCGGCTCAGCTGGCCCCAACCATCTACCCATCGGAGGAAGGGGTGACCGAGCGGGGAGCCTCGGGCCGCAAGGGCCAGGGCCGGGG ACCCCACATGTTGTCCACTGCTGTGCGCATCCACCTGGACCCCCACAAGAATGTGAAGGAGTTCCTGGTGACACTGCGGTTGCACAAAGC CACCTTGCGCCACTACATGGCCCTGCCCGAGCAGAGCTGGCATTCCCAGTTGTTGGAGTTCCTAGACGTGCTGGATGACCCTGTGCTGGG CTACCTGCCCCCGACGGTCATCACCATCCTGCACACACACCTGTTCTCCTGCTCTGTGGACTATAGGCCACTCTACCTCCCAGTGCGTGT CCTCATCACCGCGGAGACCTTCACTCTCTCCAGCAACATCATCATGGACACCTCCACCTTCCTGCTCAGGCCACTGTGGGCTCGAGTAGG GGATGACCACCTGCTGCTTCTTCAGGGAGAGCAGCTCCGCCGGACCACTCGCTCTGTTGTCCATCCCAAGTACCACCAGGGCTCAGGCCC CATCCTGCCAAGGCGAACGGATGAGCACGATCTCATGTTGCTGAAGCTGGCCAGGCCCGTAGTGCTGGGGCCCCGCGTCCGGGCCCTGCA GCTTCCCTACCGCTGTGCTCAGCCCGGAGACCAGTGCCAGGTTGCTGGCTGGGGCACCACGGCCGCCCGGAGAGTGAAGTACAACAAGGG CCTGACCTGCTCCAGCATCACTATCCTGAGCCCTAAAGAGTGTGAGGTCTTCTACCCTGGCGTGGTCACCAACAACATGATATGTGCTGG ACTGGACCGGGGCCAGGACCCTTGCCAGAGTGACTCTGGAGGCCCCCTGGTCTGTGACGAGACCCTCCAAGGCATCCTCTCGTGGGGTGT TTACCCCTGTGGCTCTGCCCAGCATCCAGCTGTCTACACCCAGATCTGCAAATACATGTCCTGGATCAATAAAGTCATACGCTCCAACTG ATCCAGATGCTACGCTCCAGCTGATCCAGATGTTATGCTCCTGCTGATCCAGATGCCCAGAGGCTCCATCGTCCATCCTCTTCCTCCCCA GTCGGCTGAACTCTCCCCTTGTCTGCACTGTTCAAACCTCTGCCGCCCTCCACACCTCTAAACATCTCCCCTCTCACCTCATTCCCCCAC CTATCCCCATTCTCTGCCTGTACTGAAGCTGAAATGCAGGAAGTGGTGGCAAAGGTTTATTCCAGAGAAGCCAGGAAGCCGGTCATCACC CAGCCTCTGAGAGCAGTTACTGGGGTCACCCAACCTGACTTCCTCTGCCACTCCCTGCTGTGTGACTTTGGGCAAGCCAAGTGCCCTCTC TGAACCTCAGTTTCCTCATCTGCAAAATGGGAACAATGACGTGCCTACCTCTTAGACATGTTGTGAGGAGACTATGATATAACATGTGTA TGTAAATCTTCATGGTGATTGTCATGTAAGGCTTAACACAGTGGGTGGTGAGTTCTGACTAAAGGTTACCTGTTGTCGTGATCTGACCAC GTCCCGGTGAAAGCGTGTGTCCAGGGAAGAAGTGCACAGGGTAGCCCCCAGTCCCAACCTTCCATCCCCAACCCTTAGGGATGATGGAAG AATCATTTTCCTCACCCTAGTTCCAAGTCCCAGGAAACACCTTTTAACCACTTCCTTCTCATCTCCCACTGTTTCCCACTTCTGGTTCCA CCCAACACCAGTTCCTCCGAGCTAGGCTGGCCCTGAGTCATTAGCACCTTCTCTGCCTTCATGAGGCCACTGAACTCAAGGGACCTCACC TTGCTTCTATCCCAGCCTCTAAGACCAGAGGGCCGAGGGGGTAGTGAAGATTGGGAAACCCTTGCCACCTCAACTGCCCAGCTTGTGCCA AGAAACCTCCCTCTGACATTTAGGGGAAAATCTTTGGTTTGTCTGTTATTAATTGGCTGTGAGATTTTCGTCCTGAAAACTTGGGAGGAG GAATTGTTTGATTCTCCCTGAAATTGGGGGAGGGAAGGGGAGTTAATACACAGAATCCAGGTAAGGCTAATAGAAGCTTCAGTGTCCGCT GGGTGTGGTGGCTCACGCCTGTAATCCTAGCACTTTGGGAGGCCGAGGAAAGCAGATCATCTGAGGTCAGGTGTTCGAGACCAGTCTGGC CAAAATGGTGAAATCCCATCTCTACTGAAAATACAAAAACTAGCCAGGCATGGTGGCAGGCACCTATAATCCCATCTACTTGGGAGGCTG AGGCAGAAGAATCACTTGAACCCGGGGGGCAGAGGTTGCAGTGAGCCAAGATTGCACCATTGCACTCCATCCAGCCTGGACAAAAGAGCA AAACTCCATCTCAAAAAAAGAAGAAGTTTGAGTGTCTCAGCTTATCCTGAACTTTGAAGCAGTAACATAAGCTAGCTGAATATAGGCACA ACAGAAATTTCCCATTAAGCACGGGGTTTTTGTTTGTTTGTTTGTCCTTTCAGTTACCAATTTATGGAGCATCTATTATGTGCCAGGCCC AGTGCTGGGTGCTGGGGACATACGTAGGGGTGATCACAAGGTCCCCCACCCTGCAGAGCCCACAGGAGGTTGATGTACAAGGTCTGAGCA CACAGCTCCCTTCCGTGGCCTCTTTCCCATTCTGCCCCCATTAGCACACGCAGGAAATGTCAGACAGGCGTATCAGCTGGGTTTGTCATC CAAAGACCAGAAGCGAGGTCGGTGGAAACTTGAAAACTCGATTCATTATTAAAGGCAACTCACCCGTCCCTTTAGTCACTCCACAATGTT TATCGAGCCACGTCTTATGCCAGGCCTCAAAGATGAATCAGACCAGGCACTACCCTCAAGGAGCTGCTAGTTAGGTCAGGGAGACAGGCC AGTCTTACATTCCTGTCATTCAGGTCTCCACTCAAAAGTCACCTCCTCCGGGAGGCCTTCCTGAATTGCCCAGGCTATAGGAGTCCACTT TTGGTCATCCAGTCCCGATGCTCTGTTTTTTGTTTGTTTGTTTTTTTTTTTAATAGCACCTATTATACCTGAAATT >7544_7544_6_ATG2A-KLK10_ATG2A_chr11_64673034_ENST00000421419_KLK10_chr19_51519412_ENST00000391805_length(amino acids)=1341AA_BP=1140 MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALL TDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEH SPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEA FPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLD NTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPD LATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEIL TFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQ QTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSK ALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSR CSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAH FFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKAT LYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMAL PEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRPLWARVGDDHLLLLQ GEQLRRTTRSVVHPKYHQGSGPILPRRTDEHDLMLLKLARPVVLGPRVRALQLPYRCAQPGDQCQVAGWGTTAARRVKYNKGLTCSSITI LSPKECEVFYPGVVTNNMICAGLDRGQDPCQSDSGGPLVCDETLQGILSWGVYPCGSAQHPAVYTQICKYMSWINKVIRSN -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for ATG2A-KLK10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for ATG2A-KLK10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for ATG2A-KLK10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0000786 | Spontaneous abortion | 1 | CTD_human | |
| Tgene | C0000822 | Abortion, Tubal | 1 | CTD_human | |
| Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
| Tgene | C0024623 | Malignant neoplasm of stomach | 1 | CTD_human | |
| Tgene | C0038356 | Stomach Neoplasms | 1 | CTD_human | |
| Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
| Tgene | C0919267 | ovarian neoplasm | 1 | CTD_human | |
| Tgene | C1140680 | Malignant neoplasm of ovary | 1 | CTD_human | |
| Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
| Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
| Tgene | C1708349 | Hereditary Diffuse Gastric Cancer | 1 | CTD_human | |
| Tgene | C3830362 | Early Pregnancy Loss | 1 | CTD_human | |
| Tgene | C4552766 | Miscarriage | 1 | CTD_human | |
| Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |
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