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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FLT1-CTNND1 (FusionGDB2 ID:HG2321TG1500) |
Fusion Gene Summary for FLT1-CTNND1 |
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Fusion gene information | Fusion gene name: FLT1-CTNND1 | Fusion gene ID: hg2321tg1500 | Hgene | Tgene | Gene symbol | FLT1 | CTNND1 | Gene ID | 2321 | 1500 |
Gene name | fms related receptor tyrosine kinase 1 | catenin delta 1 | |
Synonyms | FLT|FLT-1|VEGFR-1|VEGFR1 | BCDS2|CAS|CTNND|P120CAS|P120CTN|p120|p120(CAS)|p120(CTN) | |
Cytomap | ('FLT1')('CTNND1') 13q12.3 | 11q12.1 | |
Type of gene | protein-coding | protein-coding | |
Description | vascular endothelial growth factor receptor 1fms related tyrosine kinase 1fms-like tyrosine kinase 1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)tyrosine-protein kinase FRTtyrosine-protein ki | catenin delta-1cadherin-associated Src substratecatenin (cadherin-associated protein), delta 1p120 catenin | |
Modification date | 20200322 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000282397, ENST00000539099, ENST00000540678, ENST00000541932, ENST00000543394, | ||
Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 17 X 21 X 10=3570 |
# samples | 3 | 25 | |
** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(25/3570*10)=-3.83592407425437 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FLT1 [Title/Abstract] AND CTNND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FLT1(28964014)-CTNND1(57545740), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FLT1 | GO:0002548 | monocyte chemotaxis | 8605350|18079407 |
Hgene | FLT1 | GO:0018108 | peptidyl-tyrosine phosphorylation | 9299537|11513746 |
Hgene | FLT1 | GO:0030335 | positive regulation of cell migration | 8605350 |
Hgene | FLT1 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway | 1312256 |
Hgene | FLT1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 8605350 |
Hgene | FLT1 | GO:0036323 | vascular endothelial growth factor receptor-1 signaling pathway | 15952180 |
Hgene | FLT1 | GO:0043406 | positive regulation of MAP kinase activity | 9299537 |
Hgene | FLT1 | GO:0043410 | positive regulation of MAPK cascade | 9299537 |
Hgene | FLT1 | GO:0046777 | protein autophosphorylation | 9299537|11513746 |
Hgene | FLT1 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 9299537 |
Tgene | CTNND1 | GO:0099072 | regulation of postsynaptic membrane neurotransmitter receptor levels | 18602475 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for FLT1-CTNND1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FLT1-CTNND1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for FLT1-CTNND1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:28964014/:57545740) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FLT1-CTNND1 |
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Fusion Gene PPI Analysis for FLT1-CTNND1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FLT1-CTNND1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for FLT1-CTNND1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | FLT1 | C0006142 | Malignant neoplasm of breast | 2 | CTD_human |
Hgene | FLT1 | C0032914 | Pre-Eclampsia | 2 | CTD_human;ORPHANET |
Hgene | FLT1 | C0678222 | Breast Carcinoma | 2 | CTD_human |
Hgene | FLT1 | C1257931 | Mammary Neoplasms, Human | 2 | CTD_human |
Hgene | FLT1 | C1458155 | Mammary Neoplasms | 2 | CTD_human |
Hgene | FLT1 | C4704874 | Mammary Carcinoma, Human | 2 | CTD_human |
Hgene | FLT1 | C0007114 | Malignant neoplasm of skin | 1 | CTD_human |
Hgene | FLT1 | C0007134 | Renal Cell Carcinoma | 1 | CTD_human |
Hgene | FLT1 | C0013366 | Dyschondroplasias | 1 | CTD_human |
Hgene | FLT1 | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Hgene | FLT1 | C0019193 | Hepatitis, Toxic | 1 | CTD_human |
Hgene | FLT1 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Hgene | FLT1 | C0025202 | melanoma | 1 | CTD_human |
Hgene | FLT1 | C0025237 | Melnick-Needles Syndrome | 1 | CTD_human |
Hgene | FLT1 | C0026760 | Multiple Epiphyseal Dysplasia | 1 | CTD_human |
Hgene | FLT1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | FLT1 | C0029422 | Osteochondrodysplasias | 1 | CTD_human |
Hgene | FLT1 | C0036391 | Schwartz-Jampel Syndrome | 1 | CTD_human |
Hgene | FLT1 | C0037286 | Skin Neoplasms | 1 | CTD_human |
Hgene | FLT1 | C0038015 | Spondyloepiphyseal Dysplasia | 1 | CTD_human |
Hgene | FLT1 | C0041948 | Uremia | 1 | CTD_human |
Hgene | FLT1 | C0235874 | Disease Exacerbation | 1 | CTD_human |
Hgene | FLT1 | C0239946 | Fibrosis, Liver | 1 | CTD_human |
Hgene | FLT1 | C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 1 | CTD_human |
Hgene | FLT1 | C0432272 | Van Buchem disease | 1 | CTD_human |
Hgene | FLT1 | C0860207 | Drug-Induced Liver Disease | 1 | CTD_human |
Hgene | FLT1 | C1262760 | Hepatitis, Drug-Induced | 1 | CTD_human |
Hgene | FLT1 | C1266042 | Chromophobe Renal Cell Carcinoma | 1 | CTD_human |
Hgene | FLT1 | C1266043 | Sarcomatoid Renal Cell Carcinoma | 1 | CTD_human |
Hgene | FLT1 | C1266044 | Collecting Duct Carcinoma of the Kidney | 1 | CTD_human |
Hgene | FLT1 | C1306837 | Papillary Renal Cell Carcinoma | 1 | CTD_human |
Hgene | FLT1 | C2937358 | Cerebral Hemorrhage | 1 | CTD_human |
Hgene | FLT1 | C3541456 | Spondyloepiphyseal Dysplasia Tarda, X-Linked | 1 | CTD_human |
Hgene | FLT1 | C3658290 | Drug-Induced Acute Liver Injury | 1 | CTD_human |
Hgene | FLT1 | C4277682 | Chemical and Drug Induced Liver Injury | 1 | CTD_human |
Hgene | FLT1 | C4279912 | Chemically-Induced Liver Toxicity | 1 | CTD_human |
Hgene | FLT1 | C4551479 | Schwartz-Jampel Syndrome, Type 1 | 1 | CTD_human |
Tgene | C0008925 | Cleft Palate | 1 | GENOMICS_ENGLAND | |
Tgene | C1861536 | Blepharo-cheilo-dontic syndrome | 1 | ORPHANET |