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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:EXOC6B-CASP10 (FusionGDB2 ID:HG23233TG843)

Fusion Gene Summary for EXOC6B-CASP10

Fusion gene summary

Fusion gene information	Fusion gene name: EXOC6B-CASP10
	Fusion gene ID: hg23233tg843
		Hgene	Tgene
	Gene symbol	EXOC6B	CASP10
	Gene ID	23233	843
	Gene name	exocyst complex component 6B	caspase 10
	Synonyms	SEC15B\|SEC15L2\|SEMDJL3	ALPS2\|FLICE2\|MCH4
	Cytomap	('EXOC6B')('CASP10') 2p13.2	2q33.1
	Type of gene	protein-coding	protein-coding
	Description	exocyst complex component 6BSEC15 homolog BSEC15-like protein 2exocyst complex component Sec15B	caspase-10CASP-10FADD-like ICE2FAS-associated death domain protein interleukin-1B-converting enzyme 2ICE-like apoptotic protease 4apoptotic protease MCH-4caspase 10 apoptosis-related cysteine peptidasecaspase 10, apoptosis-related cysteine protease
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000272427, ENST00000490919, ENST00000410104,
Fusion gene scores	* DoF score	11 X 10 X 10=1100	5 X 3 X 3=45
	# samples	15	4
	** MAII score	log2(15/1100*10)=-2.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: EXOC6B [Title/Abstract] AND CASP10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	EXOC6B(72562076)-CASP10(202072798), # samples:1
Anticipated loss of major functional domain due to fusion event.	EXOC6B-CASP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EXOC6B-CASP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. EXOC6B-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EXOC6B-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. EXOC6B-CASP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. EXOC6B-CASP10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across EXOC6B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CASP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-FS-A1ZJ-06A	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+

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Fusion Gene ORF analysis for EXOC6B-CASP10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000272427	ENST00000492363	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5CDS-intron	ENST00000272427	ENST00000313728	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5CDS-intron	ENST00000272427	ENST00000346817	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5CDS-intron	ENST00000272427	ENST00000374650	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5CDS-intron	ENST00000272427	ENST00000448480	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-3CDS	ENST00000490919	ENST00000272879	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-3CDS	ENST00000490919	ENST00000286186	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-3CDS	ENST00000490919	ENST00000360132	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-3UTR	ENST00000490919	ENST00000492363	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-intron	ENST00000490919	ENST00000313728	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-intron	ENST00000490919	ENST00000346817	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-intron	ENST00000490919	ENST00000374650	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
5UTR-intron	ENST00000490919	ENST00000448480	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
Frame-shift	ENST00000272427	ENST00000360132	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
In-frame	ENST00000272427	ENST00000272879	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
In-frame	ENST00000272427	ENST00000286186	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-3CDS	ENST00000410104	ENST00000272879	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-3CDS	ENST00000410104	ENST00000286186	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-3CDS	ENST00000410104	ENST00000360132	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-3UTR	ENST00000410104	ENST00000492363	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-intron	ENST00000410104	ENST00000313728	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-intron	ENST00000410104	ENST00000346817	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-intron	ENST00000410104	ENST00000374650	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+
intron-intron	ENST00000410104	ENST00000448480	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000272427

EXOC6B

chr2

72562076

ENST00000286186

CASP10

chr2

202072798

7007

2327

3082

1022

ENST00000272427

EXOC6B

chr2

72562076

ENST00000272879

CASP10

chr2

202072798

3403

2327

3079

1021

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000272427	ENST00000286186	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+	0.000189282	0.99981076
ENST00000272427	ENST00000272879	EXOC6B	chr2	72562076	-	CASP10	chr2	202072798	+	0.000391185	0.9996088

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Fusion Genomic Features for EXOC6B-CASP10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
EXOC6B	chr2	72562075	-	CASP10	chr2	202072797	+	5.32E-06	0.99999464
EXOC6B	chr2	72562075	-	CASP10	chr2	202072797	+	5.32E-06	0.99999464

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for EXOC6B-CASP10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:72562076/chr2:202072798)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

EXOC6B

chr2:72562076

chr2:202072798

ENST00000272427

50_119

732

812.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000313728

114_187

456.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000313728

19_97

456.0

Domain

DED 1

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000374650

114_187

248.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000374650

19_97

248.0

Domain

DED 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000272879

114_187

271

522.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000272879

19_97

271

522.0

Domain

DED 1

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000286186

114_187

271

523.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000286186

19_97

271

523.0

Domain

DED 1

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000346817

114_187

228

480.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000346817

19_97

228

480.0

Domain

DED 1

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000360132

114_187

240

1541.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000360132

19_97

240

1541.0

Domain

DED 1

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000448480

114_187

228

479.0

Domain

DED 2

Tgene

CASP10

chr2:72562076

chr2:202072798

ENST00000448480

19_97

228

479.0

Domain

DED 1

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Fusion Gene Sequence for EXOC6B-CASP10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>27933_27933_1_EXOC6B-CASP10_EXOC6B_chr2_72562076_ENST00000272427_CASP10_chr2_202072798_ENST00000272879_length(transcript)=3403nt_BP=2327nt
AGGGAGGGGTCGGCCTGCGGGTAGCCAGAGGCTGGGGCGGCTGTGGAGCCTGTGGTGGGAGCGGCATTGTGGGGCAGGGAAAAGGTGAGC
CGAGCCGACGGAGGGGACGCGCTGCGGGGCGCCCCCAGTCTATGGAGCGGGGTAAGATGGCGGAGGCGGAGAGCCTGGAGACAGCGGCAG
AGCACGAGCGGATCCTGCGAGAGATCGAGAGCACTGACACGGCCTGCATCGGGCCCACGCTCAGGTCTGTTTATGATGGTGAAGAACATG
GACGTTTCATGGAGAAGCTTGAAACTCGTATCCGTAATCACGACCGAGAAATTGAGAAAATGTGCAACTTTCATTACCAGGGCTTTGTGG
ACTCTATAACTGAACTGCTGAAAGTGAGAGGAGAAGCCCAGAAACTCAAAAATCAAGTGACGGATACTAATAGAAAACTACAACATGAGG
GAAAGGAACTGGTAATAGCAATGGAAGAGCTGAAGCAGTGTCGACTACAACAGAGAAATATTTCTGCCACTGTTGATAAATTAATGCTGT
GTCTTCCAGTCCTAGAGATGTACAGCAAACTGAGGGACCAGATGAAAACTAAAAGGCATTATCCTGCACTGAAAACTCTGGAACATCTAG
AGCATACCTACCTGCCTCAAGTAAGCCACTATCGATTCTGCAAGGTGATGGTGGACAACATCCCCAAGCTTCGAGAAGAAATAAAAGATG
TTTCTATGTCCGATCTCAAAGACTTTCTGGAGAGCATCCGCAAACATTCAGACAAAATTGGAGAGACTGCCATGAAGCAAGCCCAGCAGC
AAAGAAACCTGGATAACATCGTCTTGCAACAACCCAGAATAGGTAGCAAGAGGAAATCTAAGAAAGATGCATATATAATCTTTGATACAG
AGATAGAAAGTACTAGTCCGAAGTCTGAACAGGATTCAGGAATTCTGGATGTTGAAGACGAGGAAGATGATGAAGAGGTACCTGGGGCCC
AAGATTTGGTGGATTTCTCTCCAGTTTATCGATGTCTACATATATATTCTGTCCTGGGTGCCCGGGAAACATTTGAGAATTACTACCGAA
AACAGAGGCGAAAACAGGCTCGTTTGGTACTTCAACCTCCATCTAACATGCATGAAACTTTAGATGGCTACAGGAAGTATTTTAATCAAA
TTGTAGGCTTTTTTGTGGTTGAAGATCACATTTTACATACAACCCAGGGCTTAGTAAATAGAGCCTACATTGATGAACTGTGGGAAATGG
CACTTTCAAAAACCATCGCAGCACTCCGTACCCACTCGTCTTACTGTTCTGATCCAAACCTTGTGTTAGATTTGAAGAACCTCATTGTGC
TTTTTGCTGACACACTTCAGGTGTATGGTTTCCCTGTAAATCAGCTTTTTGACATGCTGTTAGAAATCAGAGACCAATATAGTGAAACTC
TGCTAAAGAAGTGGGCAGGTATTTTCAGAAACATACTTGATTCTGACAACTACAGTCCTATACCAGTAACAAGTGAAGAGATGTACAAAA
AGGTGGTAGGACAATTCCCATTTCAAGATATAGAACTGGAAAAGCAACCATTTCCAAAAAAGTTTCCTTTCTCTGAATTTGTGCCAAAAG
TTTACAACCAAATTAAAGAATTTATCTACGCTTGTCTGAAGTTTTCAGAAGATCTTCATCTAAGCTCAACTGAAGTTGATGACATGATTC
GGAAATCAACAAACCTGTTGCTAACCAGGACTCTGAGCAACTCTCTGCAGAATGTAATTAAAAGGAAGAATATTGGGCTTACTGAGCTTG
TTCAGATTATTATCAATACAACACATTTGGAGAAATCCTGTAAGTACTTGGAAGAATTTATCACCAACATCACTAATGTGCTTCCAGAGA
CAGTTCACACTACCAAGCTCTATGGCACCACAACTTTTAAGGATGCTAGACATGCAGCTGAAGAAGAGATTTATACCAACTTAAACCAGA
AGATTGACCAGTTCCTACAGCTGGCAGACTATGACTGGATGACCGGAGATTTGGGCAACAAAGCTAGTGATTACCTGGTAGACCTCATTG
CCTTTCTTCGTAGCACCTTTGCTGTATTCACACACCTTCCTGGAAAGGTGGCCCAGACAGCGTGTATGTCAGCTTGCAAGCATTTAGCCA
CATCCTTGATGCAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCACCTTGGGAGCATTACAGCAGTTCAACTTGGACGTCAGAGAATGTG
AACAGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAGGACACGCTGCAGTTGGCCTTCATCGACTTGAGACAAAGGGCAGCTGTGT
ACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCATAAAG
ATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGACGAAAGTGGAAATGGAGATGGTCC
TGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATTTGGAGCTGTCTACT
CTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAACTCT
TTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCC
TGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCA
GCTGGTATATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCCCAAGGATGCTGAAATTTCTGGAAAAGACAATGGAAATCAGGGGCA
GGAAGAGAACAGTGTGGGGTGCTAAACAGATCTCAGCAACCTCCCTGCCCACGGCCATCTCTGCGCAGACACCTCGACCCCCCATGCGCA
GGTGGAGCAGCGTTTCCTAGTTCTTTCCAGAGGCTTCCTTCTGCCTGCCTTCCAGCCACATCGCCTGAGATTGACAACGCCCTACAGCAA
GACGGAAACCTCCCTTTACAGCACCACCTTGCGATTCTGCAGCCACAAAGTTGAGACTTCTGAACGTGGCACTCTTCTGTTCCCTTACTG
TTTCACGTGTACCTGTGTCATCTTTCTTGTTTCATCGTAAACATACTTCTAAAATTCCCATTTTCTTTATTTAGAAATAGAACTACAAGC

>27933_27933_1_EXOC6B-CASP10_EXOC6B_chr2_72562076_ENST00000272427_CASP10_chr2_202072798_ENST00000272879_length(amino acids)=1021AA_BP=771
MRVARGWGGCGACGGSGIVGQGKGEPSRRRGRAAGRPQSMERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFME
KLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVL
EMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLD
NIVLQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRK
QARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADT
LQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQI
KEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTT
KLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQ
LLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEIL
SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQA
CQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTV

--------------------------------------------------------------
>27933_27933_2_EXOC6B-CASP10_EXOC6B_chr2_72562076_ENST00000272427_CASP10_chr2_202072798_ENST00000286186_length(transcript)=7007nt_BP=2327nt
AGGGAGGGGTCGGCCTGCGGGTAGCCAGAGGCTGGGGCGGCTGTGGAGCCTGTGGTGGGAGCGGCATTGTGGGGCAGGGAAAAGGTGAGC
CGAGCCGACGGAGGGGACGCGCTGCGGGGCGCCCCCAGTCTATGGAGCGGGGTAAGATGGCGGAGGCGGAGAGCCTGGAGACAGCGGCAG
AGCACGAGCGGATCCTGCGAGAGATCGAGAGCACTGACACGGCCTGCATCGGGCCCACGCTCAGGTCTGTTTATGATGGTGAAGAACATG
GACGTTTCATGGAGAAGCTTGAAACTCGTATCCGTAATCACGACCGAGAAATTGAGAAAATGTGCAACTTTCATTACCAGGGCTTTGTGG
ACTCTATAACTGAACTGCTGAAAGTGAGAGGAGAAGCCCAGAAACTCAAAAATCAAGTGACGGATACTAATAGAAAACTACAACATGAGG
GAAAGGAACTGGTAATAGCAATGGAAGAGCTGAAGCAGTGTCGACTACAACAGAGAAATATTTCTGCCACTGTTGATAAATTAATGCTGT
GTCTTCCAGTCCTAGAGATGTACAGCAAACTGAGGGACCAGATGAAAACTAAAAGGCATTATCCTGCACTGAAAACTCTGGAACATCTAG
AGCATACCTACCTGCCTCAAGTAAGCCACTATCGATTCTGCAAGGTGATGGTGGACAACATCCCCAAGCTTCGAGAAGAAATAAAAGATG
TTTCTATGTCCGATCTCAAAGACTTTCTGGAGAGCATCCGCAAACATTCAGACAAAATTGGAGAGACTGCCATGAAGCAAGCCCAGCAGC
AAAGAAACCTGGATAACATCGTCTTGCAACAACCCAGAATAGGTAGCAAGAGGAAATCTAAGAAAGATGCATATATAATCTTTGATACAG
AGATAGAAAGTACTAGTCCGAAGTCTGAACAGGATTCAGGAATTCTGGATGTTGAAGACGAGGAAGATGATGAAGAGGTACCTGGGGCCC
AAGATTTGGTGGATTTCTCTCCAGTTTATCGATGTCTACATATATATTCTGTCCTGGGTGCCCGGGAAACATTTGAGAATTACTACCGAA
AACAGAGGCGAAAACAGGCTCGTTTGGTACTTCAACCTCCATCTAACATGCATGAAACTTTAGATGGCTACAGGAAGTATTTTAATCAAA
TTGTAGGCTTTTTTGTGGTTGAAGATCACATTTTACATACAACCCAGGGCTTAGTAAATAGAGCCTACATTGATGAACTGTGGGAAATGG
CACTTTCAAAAACCATCGCAGCACTCCGTACCCACTCGTCTTACTGTTCTGATCCAAACCTTGTGTTAGATTTGAAGAACCTCATTGTGC
TTTTTGCTGACACACTTCAGGTGTATGGTTTCCCTGTAAATCAGCTTTTTGACATGCTGTTAGAAATCAGAGACCAATATAGTGAAACTC
TGCTAAAGAAGTGGGCAGGTATTTTCAGAAACATACTTGATTCTGACAACTACAGTCCTATACCAGTAACAAGTGAAGAGATGTACAAAA
AGGTGGTAGGACAATTCCCATTTCAAGATATAGAACTGGAAAAGCAACCATTTCCAAAAAAGTTTCCTTTCTCTGAATTTGTGCCAAAAG
TTTACAACCAAATTAAAGAATTTATCTACGCTTGTCTGAAGTTTTCAGAAGATCTTCATCTAAGCTCAACTGAAGTTGATGACATGATTC
GGAAATCAACAAACCTGTTGCTAACCAGGACTCTGAGCAACTCTCTGCAGAATGTAATTAAAAGGAAGAATATTGGGCTTACTGAGCTTG
TTCAGATTATTATCAATACAACACATTTGGAGAAATCCTGTAAGTACTTGGAAGAATTTATCACCAACATCACTAATGTGCTTCCAGAGA
CAGTTCACACTACCAAGCTCTATGGCACCACAACTTTTAAGGATGCTAGACATGCAGCTGAAGAAGAGATTTATACCAACTTAAACCAGA
AGATTGACCAGTTCCTACAGCTGGCAGACTATGACTGGATGACCGGAGATTTGGGCAACAAAGCTAGTGATTACCTGGTAGACCTCATTG
CCTTTCTTCGTAGCACCTTTGCTGTATTCACACACCTTCCTGGAAAGGTGGCCCAGACAGCGTGTATGTCAGCTTGCAAGCATTTAGCCA
CATCCTTGATGCAACTTTTGTTGGAAGCTGAAGTGCGGCAGCTCACCTTGGGAGCATTACAGCAGTTCAACTTGGACGTCAGAGAATGTG
AACAGTTTGCCAGATCCGGCCCGGTGCCTGGGTTCCAGGAGGACACGCTGCAGTTGGCCTTCATCGACTTGAGACAAAGGGCAGCTGTGT
ACAGGATGAATCGGAACCACAGAGGCCTCTGTGTCATTGTCAACAACCACAGCTTTACCTCCCTGAAGGACAGACAAGGAACCCATAAAG
ATGCTGAGATCCTGAGTCATGTGTTCCAGTGGCTTGGGTTCACAGTGCATATACACAATAATGTGACGAAAGTGGAAATGGAGATGGTCC
TGCAGAAGCAGAAGTGCAATCCAGCCCATGCCGACGGGGACTGCTTCGTGTTCTGTATTCTGACCCATGGGAGATTTGGAGCTGTCTACT
CTTCGGATGAGGCCCTCATTCCCATTCGGGAGATCATGTCTCACTTCACAGCCCTGCAGTGCCCTAGACTGGCTGAAAAACCTAAACTCT
TTTTCATCCAGGCCTGCCAAGGTGAAGAGATACAGCCTTCCGTATCCATCGAAGCAGATGCTCTGAACCCTGAGCAGGCACCCACTTCCC
TGCAGGACAGTATTCCTGCCGAGGCTGACTTCCTACTTGGTCTGGCCACTGTCCCAGGCTATGTATCCTTTCGGCATGTGGAGGAAGGCA
GCTGGTATATTCAGTCTCTGTGTAATCATCTGAAGAAATTGGTCCCAAGACATGAAGACATCTTATCCATCCTCACTGCTGTCAACGATG
ATGTGAGTCGAAGAGTGGACAAACAGGGAACAAAGAAACAGATGCCCCAGCCTGCTTTCACACTAAGGAAAAAACTAGTATTCCCTGTGC
CCCTGGATGCACTTTCATTATAGCAGAGAGTTTTTGTTGGTTCTTAGACCTCAAACGAATCATTGGCTATAACCTCCAGCCTCCTGCCCA
GCACAGGAATCGGTGGTCTCCACCTGTCATTCTAGAAACAGGAAACACCGTGTTTTCTGACACAGTCAATTCTGATTTTCTTTTTCTTTT
GCAAGTCTAAATGTTAGAAAACTTTCTTTTTTTTGGAGATAGTCTCATTCTGTCACCCAGACTGGAGTGCAGGGGGGCAATCACGGCTCA
CTGTAGTCTCGACCTCCCAGGCTCAAGCTGTCCTCCCGCCTCAGCTTCCCAAGTAGCTGGGACCACAGGTGTGTACCACCGTGCCCGGAT
TTTTTTTATTCTTTATTTTTTGTAGAGATGGAGGGATCTCACTTTGTTGCACAGGCTGGTTTCAAACTCCTAGGCCCAAGTGATCCTCCC
ACCTCTGTCCCCAAAATACTGGGATTATAGGCACGAGCCACCACACCTGGCCAGAAAACTTTCATTATTGAAGACTTGGATTGTAGCCTT
GGTTTTGGATGTCTATTCTGAAGACAGAGTAATTGGCTTTGGTTTGTGCAGGTACTTTTTCTTTGAGACAGAGTCACTCCGTCACCTGGG
CTGGAGTGCAGTGGTGGGATCACTGTTCACTGCAGCCTTGACCTCCCAGGTTCAAGCGATCCTCCCACCTCAGCCTCCCAAGTAGCTGAG
ACTACAGGTGTGTGTCCATGCACAGCTAACTTTTTATTTTTTTTGTGGAGATGGGGTTTCACTATGTTGCCTAAGCTGGTCTCAAACTCC
TGGGCTCAAGCGATCCTCCCACCTCAGCTTCTCAAAGTTCTGGGACTACAGGCATGAAATACTGTGCCTGGCCTGGGGACCAGGTGCATT
TTAAGGTTCCTTGGTGTTCAAAAACCACGTTCTTAGCCTAGATTGAGCTTAGATTGCCTCTCTAGACAACTACCCCTTAGTTATAATTCT
GTGTCCCCTCTGCATGCCCTTAAACATTGGACAGTGAGGTCACAGTCCACCCACCCTCTCTCTGATCTCCCCCTTCCTAAGACTTCTCTT
TTGCACATCTAGTGAGGTGAAAATTTGGTCTATGCCAGGCCCATTTCCTGCTTTTGTGTAAGGAAGGTGCTCACATAGGAAGTTTTTATT
TGGTTAGAGACAGGTTTCCCTGTAGGAAGATGATGGCTCATTTACACTCAGCTGCTCTGCAAGCAGAAACTTTACAACCTGATGTCATAT
TCCATTTTGGACTGGGTGCGGTGACTCATGCCTGTAATCCCAGTACTCTGGGAAGCCAAGGCAGGCAGATCACTTGAGGTCAGGAGTTCG
AGACCAGCCTGGCCAATACGGCAAAACCTCATCATTACTAAAAACACAAAAATTAGCCAGGTGTGGCGGCGAGCACCTGTAATCCCAGCT
ACTCGGGAGGCTGAGACAGGAGAATCTCTTGAATCCAGGAGGCAGAGGCTGTGGTGAGCCAAGATGACACAACTGCACTCCAGCTTGGGC
AACAGGGCGAGACCTTGTTTAAAAAAAAAATTCAATATTGGGGTTGGAACATTTCAGTTGCCATTGACAGAACACCCAATTCAAATTGAC
TGAAGCAAAGAAGGGAATTTATTGCCTCTTTCACATTGAAACCCAGGAGTGGATAACACTGGCTTCAGGCAAAGCTTGAATCAGGACTCA
ATCTACAGGCCAGCACCTTTCTCTTGGCCGGATGTCCTCAGGGCTGGCAGATGCAGTAGACTGCAGTGGACAGTCCCCACCTTGTTACTG
CTACTACACTTTGCTCCTCTGGCCCAAGGCATGAGGAGAGAGGCTGTGTCAGAAACTGAAGCTGTTCTCAGGATCACTGGGCTCTTCTTG
GCAGAGGGGATGTCTGGCTTGCCTGAAGGGAGTGGCTCTGTAAGGACGCCTTGATGCTTTCTTCATTAAGATTTTGAGCATTTTTACGTA
CTTGAGCTTTTTTTTTTTTTTTTTTCAATTTCTAGAGGAACTTTTTCTCTGTTAATTCCTGGAACTGTATTTTGAATCCTTAAAGGTGAG
CCCTCATAGGGAGATCCAAAGTCCTGTGGTTAACGCCTTCATTTATAGATGAGGCAGCTGAGGCCTGGGGATGTGAACAACCTGCTCACA
GTCCTCATTTACTGGATTTGACTTCAGCCAGGTGAACTGGAATGCCTTGGGGCGTGGAAGGGCATTAGGAGTGTTTCATTTGATATGTGA
ATGCTCATAAAAAAATGTCAAGGAATGAAGAACAACAACTCTCAGTGGTGCCTGCATTTATAATTATTTATGTGAAAGTCAAATTCATGT
ACAGTAAATTTGTTATAAGAATATTCACAAGAACACTGTTCTGATATCTCTGATTGTCATGTGGATTTGAATGTAGCTTGACAGAGGGAA
TGTCTAATCTATATTGACAGGGCAGGAACACCGTCATCTTAGACAAACACCGCCACTTTAAGTTCCAGTTCCCTTTCTAGCCTCATGCAT
TTCAAGGAAATCACTTCTTTTCTAACAGCGAGCAGCCAGAAAGAGAAGAGAGTAAAATACAGATAAGACAGCTCTGGCATAGAGGGAGGT
GGGGGGGTGGGGGAAGTCTCTTGGGTAACTGCCAAACTTTGCCTTCATACAATGGGTTCCAGGAAAACAATGAGCCTTAATAAGCACATT
CCTTTCCCTTCAGGTGCACTAAGTGGGGAAGCTAAAAGCAGACTGGAGGGGGGTGGGGTGTACCTACAGCTGCAGAAATATTGTATGGGA
ACGGACACACAACTCTCCCTCCCAGATAAGCACAGCAAAGAGACATAGAAGCAATCCAAGCCTCTGATAAACTCTCCCACCCTAAATCCT
TAAAAACTCTTAGTCTGTAAGTGAGTGGGCTCTGACCTAACTCGGCCAGAAGCCCCTTTCAAATTTGTTTTCTCTAAAATAAACCTGTCC
TTGGCTGTCAAGCCACCTTTCATGTTTCTTTCCTCTTTCTTTAATTCTTACACATGTGTCAGGATGATCTCCCAAAACCGTGTTCATAAC
AGTCAGGGCCAAAAGCTAGTGGTCACAGTCCTTGTCCAGTTGGCAGAACTGACATGTGAAGGCAAGTGAAGGATGGTGAGATACTGAGGA
AAGAGCAAAGGATCTGGAGATCAAAGCCCTGCATTTCCATTTTGTCCTGATTCCTTTGCTCAGAGACACTAACTAAATCAAGCTAGCTTT
TTTCAGCCTTGTCTGTAAAGTAGAGAAAACATTAGCTGTTGGGAAGACGAAAAAGAATGTGTCCTATGTGTGCATCTATTTAAATCTAAC
TGTGCTGAGGTGCATATAAATGCCTTTAGGTGGTAGGGTCTTCCGGTTGTAACTGCAACAGAAATAGCAGGACTTAAGTTCCTTTGTGCG
TAATTCCAGCTGACTTTATTAGCGGCAACTCAGCACTAGCATTACCCCTGACATACTCTGAGTAAGATCTAATTCTTCCCTCACTGGTTC
GTGATGTCTACCGCAGCAGAAGGCCAGCTCTTGACTCTGAGTTCAGTTGGACAAAATGCTGTTGATAAAACCTCCTGTCAGGCCTCTGAG
CCCAAGCTAAGCCATCATATCCCTTGTGACCTGCACATATATATCCAGATGGCCTGAAGTAACTGAAGAATCACAAAAGAAGTGAAAATG
GCCTGTTCCTGCCTTAACTGATGACATTACCTTGTGAAATTCCTTCTCCTGGCTCATCCTGGCTCAAAAGCTCCCCCAGTGAGCACCTTG
TGACCCCCATCCCTGCCAGCCAGAGAACAACCCCCTTTGACTGTAATTTTCCACTACTTACCCAAATCCTATAAAACGGCCCCACCCCTA

>27933_27933_2_EXOC6B-CASP10_EXOC6B_chr2_72562076_ENST00000272427_CASP10_chr2_202072798_ENST00000286186_length(amino acids)=1022AA_BP=771
MRVARGWGGCGACGGSGIVGQGKGEPSRRRGRAAGRPQSMERGKMAEAESLETAAEHERILREIESTDTACIGPTLRSVYDGEEHGRFME
KLETRIRNHDREIEKMCNFHYQGFVDSITELLKVRGEAQKLKNQVTDTNRKLQHEGKELVIAMEELKQCRLQQRNISATVDKLMLCLPVL
EMYSKLRDQMKTKRHYPALKTLEHLEHTYLPQVSHYRFCKVMVDNIPKLREEIKDVSMSDLKDFLESIRKHSDKIGETAMKQAQQQRNLD
NIVLQQPRIGSKRKSKKDAYIIFDTEIESTSPKSEQDSGILDVEDEEDDEEVPGAQDLVDFSPVYRCLHIYSVLGARETFENYYRKQRRK
QARLVLQPPSNMHETLDGYRKYFNQIVGFFVVEDHILHTTQGLVNRAYIDELWEMALSKTIAALRTHSSYCSDPNLVLDLKNLIVLFADT
LQVYGFPVNQLFDMLLEIRDQYSETLLKKWAGIFRNILDSDNYSPIPVTSEEMYKKVVGQFPFQDIELEKQPFPKKFPFSEFVPKVYNQI
KEFIYACLKFSEDLHLSSTEVDDMIRKSTNLLLTRTLSNSLQNVIKRKNIGLTELVQIIINTTHLEKSCKYLEEFITNITNVLPETVHTT
KLYGTTTFKDARHAAEEEIYTNLNQKIDQFLQLADYDWMTGDLGNKASDYLVDLIAFLRSTFAVFTHLPGKVAQTACMSACKHLATSLMQ
LLLEAEVRQLTLGALQQFNLDVRECEQFARSGPVPGFQEDTLQLAFIDLRQRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEIL
SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQA
CQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRHEDILSILTAVNDDVSRR

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Fusion Gene PPI Analysis for EXOC6B-CASP10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for EXOC6B-CASP10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for EXOC6B-CASP10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	EXOC6B	C0432243	Spondyloepimetaphyseal Dysplasia With Joint Laxity	2	ORPHANET
Tgene		C1328840	Autoimmune Lymphoproliferative Syndrome	2	ORPHANET
Tgene		C1858968	Autoimmune Lymphoproliferative Syndrome, Type IIA	2	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene		C0007114	Malignant neoplasm of skin	1	CTD_human
Tgene		C0025202	melanoma	1	CTD_human
Tgene		C0037286	Skin Neoplasms	1	CTD_human
Tgene		C0699791	Stomach Carcinoma	1	CGI;UNIPROT
Tgene		C4721532	Lymphoma, Non-Hodgkin, Familial	1	CTD_human;UNIPROT

Fusion Gene Studies in Kim Lab

Fusion gene:EXOC6B-CASP10 (FusionGDB2 ID:HG23233TG843)

Fusion Gene Summary for EXOC6B-CASP10

Fusion Gene ORF analysis for EXOC6B-CASP10

Fusion Genomic Features for EXOC6B-CASP10

Fusion Protein Features for EXOC6B-CASP10

Fusion Gene Sequence for EXOC6B-CASP10

Fusion Gene PPI Analysis for EXOC6B-CASP10

Related Drugs for EXOC6B-CASP10

Related Diseases for EXOC6B-CASP10

Fusion Gene Studies
in Kim Lab