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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FBXW11-RAC1 (FusionGDB2 ID:HG23291TG5879)

Fusion Gene Summary for FBXW11-RAC1

check button Fusion gene summary
Fusion gene informationFusion gene name: FBXW11-RAC1
Fusion gene ID: hg23291tg5879
HgeneTgene
Gene symbol

FBXW11

RAC1

Gene ID

23291

5879

Gene nameF-box and WD repeat domain containing 11Rac family small GTPase 1
SynonymsBTRC2|BTRCP2|FBW1B|FBXW1B|Fbw11|HosMIG5|MRD48|Rac-1|TC-25|p21-Rac1
Cytomap('FBXW11')('RAC1')

5q35.1

7p22.1

Type of geneprotein-codingprotein-coding
DescriptionF-box/WD repeat-containing protein 11F-box and WD repeats protein beta-TrCP2F-box and WD-40 domain protein 11F-box and WD-40 domain protein 1BF-box protein Fbw1bF-box/WD repeat-containing protein 1Bbeta-transducin repeat-containing protein 2homologras-related C3 botulinum toxin substrate 1cell migration-inducing gene 5 proteinras-like protein TC25ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Modification date2020032920200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265094, ENST00000296933, 
ENST00000393802, ENST00000425623, 
ENST00000522891, 
Fusion gene scores* DoF score13 X 6 X 9=70217 X 10 X 5=850
# samples 1318
** MAII scorelog2(13/702*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/850*10)=-2.23946593469539
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FBXW11 [Title/Abstract] AND RAC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFBXW11(171433462)-RAC1(6439757), # samples:1
Anticipated loss of major functional domain due to fusion event.FBXW11-RAC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FBXW11-RAC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFBXW11

GO:0000209

protein polyubiquitination

20347421

HgeneFBXW11

GO:0016567

protein ubiquitination

16885022

HgeneFBXW11

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

20347421

HgeneFBXW11

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

20347421

TgeneRAC1

GO:0010592

positive regulation of lamellipodium assembly

15467718

TgeneRAC1

GO:0031529

ruffle organization

15467718

TgeneRAC1

GO:0032707

negative regulation of interleukin-23 production

16982892

TgeneRAC1

GO:0048870

cell motility

19403692

TgeneRAC1

GO:0051496

positive regulation of stress fiber assembly

23129259

TgeneRAC1

GO:0051894

positive regulation of focal adhesion assembly

23129259

TgeneRAC1

GO:0060263

regulation of respiratory burst

16636067

TgeneRAC1

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

23129259


check buttonFusion gene breakpoints across FBXW11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RAC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8209-01AFBXW11chr5

171433462

-RAC1chr7

6439757

+


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Fusion Gene ORF analysis for FBXW11-RAC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000265094ENST00000488373FBXW11chr5

171433462

-RAC1chr7

6439757

+
5CDS-3UTRENST00000296933ENST00000488373FBXW11chr5

171433462

-RAC1chr7

6439757

+
5CDS-3UTRENST00000393802ENST00000488373FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000265094ENST00000348035FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000265094ENST00000356142FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000296933ENST00000348035FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000296933ENST00000356142FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000393802ENST00000348035FBXW11chr5

171433462

-RAC1chr7

6439757

+
In-frameENST00000393802ENST00000356142FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3CDSENST00000425623ENST00000348035FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3CDSENST00000425623ENST00000356142FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3CDSENST00000522891ENST00000348035FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3CDSENST00000522891ENST00000356142FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3UTRENST00000425623ENST00000488373FBXW11chr5

171433462

-RAC1chr7

6439757

+
intron-3UTRENST00000522891ENST00000488373FBXW11chr5

171433462

-RAC1chr7

6439757

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296933FBXW11chr5171433462-ENST00000348035RAC1chr76439757+2301416290769159
ENST00000296933FBXW11chr5171433462-ENST00000356142RAC1chr76439757+844416600100166
ENST00000265094FBXW11chr5171433462-ENST00000348035RAC1chr76439757+206818357536159
ENST00000265094FBXW11chr5171433462-ENST00000356142RAC1chr76439757+61118357536159
ENST00000393802FBXW11chr5171433462-ENST00000348035RAC1chr76439757+207819367546159
ENST00000393802FBXW11chr5171433462-ENST00000356142RAC1chr76439757+62119367546159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296933ENST00000348035FBXW11chr5171433462-RAC1chr76439757+0.0227851440.9772149
ENST00000296933ENST00000356142FBXW11chr5171433462-RAC1chr76439757+0.027671810.9723282
ENST00000265094ENST00000348035FBXW11chr5171433462-RAC1chr76439757+0.0074165930.9925834
ENST00000265094ENST00000356142FBXW11chr5171433462-RAC1chr76439757+0.0127309840.98726904
ENST00000393802ENST00000348035FBXW11chr5171433462-RAC1chr76439757+0.0073728710.9926271
ENST00000393802ENST00000356142FBXW11chr5171433462-RAC1chr76439757+0.0150937670.98490626

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Fusion Genomic Features for FBXW11-RAC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FBXW11chr5171433461-RAC1chr76439756+8.57E-060.9999914
FBXW11chr5171433461-RAC1chr76439756+8.57E-060.9999914

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FBXW11-RAC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171433462/chr7:6439757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRAC1chr5:171433462chr7:6439757ENST0000034803526116_11875193.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST0000034803526159_16075193.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST0000035614237116_11894212.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST0000035614237159_16094212.0Nucleotide bindingGTP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113129_167151360.3333333333333DomainF-box
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113129_167151283.6666666666667DomainF-box
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112129_16715592.0DomainF-box
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-11367_116151360.3333333333333RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-11367_116151283.6666666666667RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-11267_11615592.0RegionHomodimerization domain D
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113238_275151360.3333333333333RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113278_315151360.3333333333333RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113318_355151360.3333333333333RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113361_398151360.3333333333333RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113401_440151360.3333333333333RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113442_478151360.3333333333333RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr7:6439757ENST00000265094-113490_527151360.3333333333333RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113238_275151283.6666666666667RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113278_315151283.6666666666667RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113318_355151283.6666666666667RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113361_398151283.6666666666667RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113401_440151283.6666666666667RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113442_478151283.6666666666667RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr7:6439757ENST00000296933-113490_527151283.6666666666667RepeatNote=WD 7
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112238_27515592.0RepeatNote=WD 1
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112278_31515592.0RepeatNote=WD 2
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112318_35515592.0RepeatNote=WD 3
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112361_39815592.0RepeatNote=WD 4
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112401_44015592.0RepeatNote=WD 5
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112442_47815592.0RepeatNote=WD 6
HgeneFBXW11chr5:171433462chr7:6439757ENST00000393802-112490_52715592.0RepeatNote=WD 7
TgeneRAC1chr5:171433462chr7:6439757ENST000003480352632_4075193.0MotifEffector region
TgeneRAC1chr5:171433462chr7:6439757ENST000003561423732_4094212.0MotifEffector region
TgeneRAC1chr5:171433462chr7:6439757ENST000003480352613_1875193.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST000003480352630_3575193.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST000003561423713_1894212.0Nucleotide bindingGTP
TgeneRAC1chr5:171433462chr7:6439757ENST000003561423730_3594212.0Nucleotide bindingGTP


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Fusion Gene Sequence for FBXW11-RAC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29887_29887_1_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000265094_RAC1_chr7_6439757_ENST00000348035_length(transcript)=2068nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCAC
TGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTG
ACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGC
CTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATG
TCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAAAAAAAAAACA
ACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGTAATTTTAAGG
TTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACATTCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCCTTATTTTTCA
AAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTGCCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAACACCGAGCACT
GAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTAGCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAGTTCTCAGATG
CGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCATTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAACATTGTACTGT
AATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAGTCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGAGATTTTGAAC
AGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAGCTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAGACAGTATTTT
GACAAAATACGAAGTGGAGATTTACACTACATTGTACAAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATTTCTGTCAAAT
GCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGAAATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCCTCCCCAAATT
GGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTAGTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGACTGAGCAATA
TGCCTCCTTGTATTATAAAATCTTTCTGATAATGCATTAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTACTTTATTCAG
AGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAGGTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATTTTAGATAATT
CTTAAACTATGAACCTTCTTAACATCACTGTCTTGCCAGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTACCTCGCCCACG
CGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGATGTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTGACGATGTTCT
GTACAACTTAACTCACTGGCGAGAATACAGCGTGGGACCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCAGAATTGTGGA
GTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCATTATGTTTTGCATGTATGACTTAATAAATCCTTGAATCATACGACTGGTAA

>29887_29887_1_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000265094_RAC1_chr7_6439757_ENST00000348035_length(amino acids)=159AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK
DTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

--------------------------------------------------------------
>29887_29887_2_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000265094_RAC1_chr7_6439757_ENST00000356142_length(transcript)=611nt_BP=183nt
CTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGG
CCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTC
ATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCAC
TGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTG
ACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGC
CTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATG
TCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAA

>29887_29887_2_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000265094_RAC1_chr7_6439757_ENST00000356142_length(amino acids)=159AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK
DTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

--------------------------------------------------------------
>29887_29887_3_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000296933_RAC1_chr7_6439757_ENST00000348035_length(transcript)=2301nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTC
CTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAAC
TTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTA
AGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCC
TCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACC
TTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAAAAAAAAAACAACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTT
ACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGTAATTTTAAGGTTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACAT
TCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCCTTATTTTTCAAAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTG
CCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAACACCGAGCACTGAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTA
GCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAGTTCTCAGATGCGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCA
TTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAACATTGTACTGTAATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAG
TCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGAGATTTTGAACAGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAG
CTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAGACAGTATTTTGACAAAATACGAAGTGGAGATTTACACTACATTGTAC
AAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATTTCTGTCAAATGCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGA
AATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCCTCCCCAAATTGGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTA
GTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGACTGAGCAATATGCCTCCTTGTATTATAAAATCTTTCTGATAATGCAT
TAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTACTTTATTCAGAGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAG
GTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATTTTAGATAATTCTTAAACTATGAACCTTCTTAACATCACTGTCTTGCC
AGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTACCTCGCCCACGCGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGAT
GTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTGACGATGTTCTGTACAACTTAACTCACTGGCGAGAATACAGCGTGGGA
CCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCAGAATTGTGGAGTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCA
TTATGTTTTGCATGTATGACTTAATAAATCCTTGAATCATACGACTGGTAA

>29887_29887_3_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000296933_RAC1_chr7_6439757_ENST00000348035_length(amino acids)=159AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK
DTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

--------------------------------------------------------------
>29887_29887_4_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000296933_RAC1_chr7_6439757_ENST00000356142_length(transcript)=844nt_BP=416nt
GTAGTCGTGGCGCTCTCGAGGCCCTGCCATGAGCAAGCTCTTAACTCTTCAGGTCTGCACGTCCTACGCCCACCGTCCAGTGCTACTCTC
AGCTCGGAGTTCAGCTTCGGGCTGCCAAGAGCCAGCAACCTGGTGTCAGAGGCTCGGTCCCACAACGCTCTGCGGGCCGCGGCGCCTGCT
GGGAGGTGTAGTCCCCGATCTGCGTACTGCGTTCGCCGAGGGGGAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGG
TGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCCTCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCG
CCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGACCATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTC
CTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGTGCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAAC
TTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGAGAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTA
AGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCACACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCC
TCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCTGTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACC
TTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAA

>29887_29887_4_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000296933_RAC1_chr7_6439757_ENST00000356142_length(amino acids)=166AA_BP=0
MGVSFFSFSFSIVSLSSLRSSLVPTRMMGVLGQWCRTSGYHFARTFSNDAGLTREKQIKNTSMSSMVLSSITESGSMAAPAAPPRSPRAA
ANGPGGGGDGGGGRGGGGYRTHSSCQPARAAGSSALPLGERSTQIGDYTSQQAPRPAERCGTEPLTPGCWLLAARS

--------------------------------------------------------------
>29887_29887_5_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000393802_RAC1_chr7_6439757_ENST00000348035_length(transcript)=2078nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGT
GCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGA
GAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCAC
ACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCT
GTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACAAAA
AAAAAAAACAACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTTTGAACCAATCAGT
AATTTTAAGGTTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACATTCTATTAAAATTTAGCCCTAAAATGACAAGCCTTCTTAAAGCC
TTATTTTTCAAAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTGCCAAAATACCTTCTGAACTACACTGCATTGTTGTGCCGAGAAC
ACCGAGCACTGAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTAGCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAG
TTCTCAGATGCGTAAAGCAGAACAGCCTCCCGAATGAAGCGTTGCCATTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAAC
ATTGTACTGTAATGGAGTGAGCGTAGCAGCTCAGCTCTTTGGATCAGTCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGA
GATTTTGAACAGAACTGCTATTTCCTCTAATGAAGAATTCTGTTTAGCTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAG
ACAGTATTTTGACAAAATACGAAGTGGAGATTTACACTACATTGTACAAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTAATT
TCTGTCAAATGCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGAAATGTTTTCTTAAGCTTTTCCTTTCTCTTACACCTGCCATGCC
TCCCCAAATTGGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTAGTCGCTAACTTAGTAAGTGCTTTTCTTATAGAACCCCTTCTGA
CTGAGCAATATGCCTCCTTGTATTATAAAATCTTTCTGATAATGCATTAGAAGGTTTTTTTGTCGATTAGTAAAAGTGCTTTCCATGTTA
CTTTATTCAGAGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAGGTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATT
TTAGATAATTCTTAAACTATGAACCTTCTTAACATCACTGTCTTGCCAGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTAC
CTCGCCCACGCGGACACACGCCTCCTGTAGTCGCTTTGCCTATTGATGTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTG
ACGATGTTCTGTACAACTTAACTCACTGGCGAGAATACAGCGTGGGACCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCA
GAATTGTGGAGTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCATTATGTTTTGCATGTATGACTTAATAAATCCTTGAATCATACG
ACTGGTAA

>29887_29887_5_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000393802_RAC1_chr7_6439757_ENST00000348035_length(amino acids)=159AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK
DTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

--------------------------------------------------------------
>29887_29887_6_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000393802_RAC1_chr7_6439757_ENST00000356142_length(transcript)=621nt_BP=193nt
GAGGGCGGAGCTGCCGGCGGCCCGGGCGGGCTGGCAGCTAGAGTGGGTGCGATAGCCGCCTCCGCCTCTGCCGCCTCCGCCGTCGCCTCC
TCCGCCCGGGCCGTTCGCTGCTGCGCGGGGAGAGCGAGGCGGGGCCGCCGGGGCCGCCATGGAGCCCGACTCGGTGATTGAGGACAAGAC
CATCGAGCTCATGGATGTGTTCTTAATTTGCTTTTCCCTTGTGAGTCCTGCATCATTTGAAAATGTCCGTGCAAAGTGGTATCCTGAGGT
GCGGCACCACTGTCCCAACACTCCCATCATCCTAGTGGGAACTAAACTTGATCTTAGGGATGATAAAGACACGATCGAGAAACTGAAGGA
GAAGAAGCTGACTCCCATCACCTATCCGCAGGGTCTAGCCATGGCTAAGGAGATTGGTGCTGTAAAATACCTGGAGTGCTCGGCGCTCAC
ACAGCGAGGCCTCAAGACAGTGTTTGACGAAGCGATCCGAGCAGTCCTCTGCCCGCCTCCCGTGAAGAAGAGGAAGAGAAAATGCCTGCT
GTTGTAAATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAA

>29887_29887_6_FBXW11-RAC1_FBXW11_chr5_171433462_ENST00000393802_RAC1_chr7_6439757_ENST00000356142_length(amino acids)=159AA_BP=40
MPPPPSPPPPGPFAAARGERGGAAGAAMEPDSVIEDKTIELMDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDK
DTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for FBXW11-RAC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FBXW11-RAC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FBXW11-RAC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFBXW11C0557874Global developmental delay1GENOMICS_ENGLAND
HgeneFBXW11C2677504AUTISM, SUSCEPTIBILITY TO, 151GENOMICS_ENGLAND
HgeneFBXW11C3550704Abnormality of digit1GENOMICS_ENGLAND
HgeneFBXW11C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneFBXW11C4021812Abnormality of the head1GENOMICS_ENGLAND
HgeneFBXW11C4316870Abnormality of the eye1GENOMICS_ENGLAND
TgeneC0011570Mental Depression2PSYGENET
TgeneC0011581Depressive disorder2PSYGENET
TgeneC0007193Cardiomyopathy, Dilated1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0011849Diabetes Mellitus1CTD_human
TgeneC0018801Heart failure1CTD_human
TgeneC0018802Congestive heart failure1CTD_human
TgeneC0023212Left-Sided Heart Failure1CTD_human
TgeneC0023895Liver diseases1CTD_human
TgeneC0025202melanoma1CGI;CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0086565Liver Dysfunction1CTD_human
TgeneC0235527Heart Failure, Right-Sided1CTD_human
TgeneC0242698Ventricular Dysfunction, Left1CTD_human
TgeneC0424605Developmental delay (disorder)1GENOMICS_ENGLAND
TgeneC0557874Global developmental delay1GENOMICS_ENGLAND
TgeneC0876994Cardiotoxicity1CTD_human
TgeneC1449563Cardiomyopathy, Familial Idiopathic1CTD_human
TgeneC1959583Myocardial Failure1CTD_human
TgeneC1961112Heart Decompensation1CTD_human
TgeneC2239176Liver carcinoma1CTD_human
TgeneC3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC4540321MENTAL RETARDATION, AUTOSOMAL DOMINANT 481ORPHANET;UNIPROT