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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:NEDD4L-MBD2 (FusionGDB2 ID:HG23327TG8932)

Fusion Gene Summary for NEDD4L-MBD2

check button Fusion gene summary
Fusion gene informationFusion gene name: NEDD4L-MBD2
Fusion gene ID: hg23327tg8932
HgeneTgene
Gene symbol

NEDD4L

MBD2

Gene ID

23327

8932

Gene nameNEDD4 like E3 ubiquitin protein ligasemethyl-CpG binding domain protein 2
SynonymsNEDD4-2|NEDD4.2|PVNH7|RSP5|hNEDD4-2DMTase|NY-CO-41
Cytomap('NEDD4L')('MBD2')

18q21.31

18q21.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase NEDD4-likeHECT-type E3 ubiquitin transferase NED4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligaseubiquitin-protein ligase Rsp5methyl-CpG-binding domain protein 2demethylase
Modification date2020032920200313
UniProtAcc.

Q9UBB5

Ensembl transtripts involved in fusion geneENST00000256830, ENST00000356462, 
ENST00000382850, ENST00000400345, 
ENST00000589054, ENST00000256832, 
ENST00000357895, ENST00000431212, 
ENST00000435432, ENST00000456173, 
ENST00000456986, ENST00000586263, 
ENST00000588516, 
Fusion gene scores* DoF score28 X 18 X 11=554413 X 7 X 7=637
# samples 3515
** MAII scorelog2(35/5544*10)=-3.98550043030488
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/637*10)=-2.08633087176042
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NEDD4L [Title/Abstract] AND MBD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNEDD4L(55711940)-MBD2(51715381), # samples:1
Anticipated loss of major functional domain due to fusion event.NEDD4L-MBD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4L-MBD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4L-MBD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NEDD4L-MBD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNEDD4L

GO:0003254

regulation of membrane depolarization

15217910

HgeneNEDD4L

GO:0006511

ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0010038

response to metal ion

11244092

HgeneNEDD4L

GO:0016567

protein ubiquitination

15217910|25631046

HgeneNEDD4L

GO:0034765

regulation of ion transmembrane transport

17289006

HgeneNEDD4L

GO:0042391

regulation of membrane potential

17289006

HgeneNEDD4L

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

21463633

HgeneNEDD4L

GO:0060306

regulation of membrane repolarization

21463633

HgeneNEDD4L

GO:0070936

protein K48-linked ubiquitination

21463633

HgeneNEDD4L

GO:1901016

regulation of potassium ion transmembrane transporter activity

17289006

HgeneNEDD4L

GO:1901017

negative regulation of potassium ion transmembrane transporter activity

21463633

HgeneNEDD4L

GO:1901380

negative regulation of potassium ion transmembrane transport

21463633

HgeneNEDD4L

GO:1902306

negative regulation of sodium ion transmembrane transport

15217910

HgeneNEDD4L

GO:1903861

positive regulation of dendrite extension

23999003

HgeneNEDD4L

GO:2000009

negative regulation of protein localization to cell surface

21463633

HgeneNEDD4L

GO:2000650

negative regulation of sodium ion transmembrane transporter activity

15217910


check buttonFusion gene breakpoints across NEDD4L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-ET-A40PNEDD4Lchr18

55711940

+MBD2chr18

51715381

-


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Fusion Gene ORF analysis for NEDD4L-MBD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000256830ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000256830ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000256830ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000356462ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000356462ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000356462ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000382850ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000382850ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000382850ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000400345ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000400345ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000400345ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000589054ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000589054ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5CDS-intronENST00000589054ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5UTR-3CDSENST00000256832ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5UTR-intronENST00000256832ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5UTR-intronENST00000256832ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
5UTR-intronENST00000256832ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
In-frameENST00000256830ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
In-frameENST00000356462ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
In-frameENST00000382850ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
In-frameENST00000400345ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
In-frameENST00000589054ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000357895ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000431212ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000435432ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000456173ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000456986ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000586263ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-3CDSENST00000588516ENST00000256429NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000357895ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000357895ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000357895ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000431212ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000431212ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000431212ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000435432ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000435432ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000435432ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456173ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456173ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456173ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456986ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456986ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000456986ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000586263ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000586263ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000586263ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000588516ENST00000398398NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000588516ENST00000579025NEDD4Lchr18

55711940

+MBD2chr18

51715381

-
intron-intronENST00000588516ENST00000583046NEDD4Lchr18

55711940

+MBD2chr18

51715381

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356462NEDD4Lchr1855711940+ENST00000256429MBD2chr1851715381-3491342210875221
ENST00000400345NEDD4Lchr1855711940+ENST00000256429MBD2chr1851715381-3480331199864221
ENST00000589054NEDD4Lchr1855711940+ENST00000256429MBD2chr1851715381-3474325193858221
ENST00000382850NEDD4Lchr1855711940+ENST00000256429MBD2chr1851715381-331016129694221
ENST00000256830NEDD4Lchr1855711940+ENST00000256429MBD2chr1851715381-3197480581193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356462ENST00000256429NEDD4Lchr1855711940+MBD2chr1851715381-0.0012736540.9987263
ENST00000400345ENST00000256429NEDD4Lchr1855711940+MBD2chr1851715381-0.0012762490.9987237
ENST00000589054ENST00000256429NEDD4Lchr1855711940+MBD2chr1851715381-0.0012553780.9987446
ENST00000382850ENST00000256429NEDD4Lchr1855711940+MBD2chr1851715381-0.0011161080.9988839
ENST00000256830ENST00000256429NEDD4Lchr1855711940+MBD2chr1851715381-0.0010120640.998988

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Fusion Genomic Features for NEDD4L-MBD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NEDD4L-MBD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:55711940/chr18:51715381)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MBD2

Q9UBB5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters. {ECO:0000269|PubMed:10471499, ECO:0000269|PubMed:10947852, ECO:0000269|PubMed:12665568, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:24307175, ECO:0000269|PubMed:9774669}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMBD2chr18:55711940chr18:51715381ENST000005830460350_960303.0Compositional biasNote=Arg-rich
TgeneMBD2chr18:55711940chr18:51715381ENST00000583046036_1400303.0Compositional biasNote=Gly-rich
TgeneMBD2chr18:55711940chr18:51715381ENST0000058304603145_2130303.0DomainMBD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+128193_22616872.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+128385_41816872.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+128497_53016872.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+1284_12616872.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+128548_58116872.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000256830+128640_97416872.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+129193_22616912.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+129385_41816912.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+129497_53016912.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+1294_12616912.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+129548_58116912.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000356462+129640_97416912.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+131193_2260968.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+131385_4180968.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+131497_5300968.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+1314_1260968.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+131548_5810968.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000357895+131640_9740968.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+130193_22616956.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+130385_41816956.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+130497_53016956.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+1304_12616956.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+130548_58116956.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000382850+130640_97416956.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+131193_22616976.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+131385_41816976.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+131497_53016976.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+1314_12616976.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+131548_58116976.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000400345+131640_97416976.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+130193_2260855.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+130385_4180855.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+130497_5300855.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+1304_1260855.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+130548_5810855.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000431212+130640_9740855.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+131193_2260835.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+131385_4180835.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+131497_5300835.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+1314_1260835.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+131548_5810835.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000435432+131640_9740835.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+129193_2260835.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+129385_4180835.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+129497_5300835.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+1294_1260835.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+129548_5810835.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456173+129640_9740835.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+131193_2260855.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+131385_4180855.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+131497_5300855.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+1314_1260855.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+131548_5810855.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000456986+131640_9740855.0DomainHECT
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+130193_2260948.0DomainWW 1
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+130385_4180948.0DomainWW 2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+130497_5300948.0DomainWW 3
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+1304_1260948.0DomainC2
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+130548_5810948.0DomainWW 4
HgeneNEDD4Lchr18:55711940chr18:51715381ENST00000586263+130640_9740948.0DomainHECT
TgeneMBD2chr18:55711940chr18:51715381ENST000002564291750_962341015.6666666666666Compositional biasNote=Arg-rich
TgeneMBD2chr18:55711940chr18:51715381ENST00000256429176_1402341015.6666666666666Compositional biasNote=Gly-rich
TgeneMBD2chr18:55711940chr18:51715381ENST0000025642917145_2132341015.6666666666666DomainMBD


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Fusion Gene Sequence for NEDD4L-MBD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>58422_58422_1_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000256830_MBD2_chr18_51715381_ENST00000256429_length(transcript)=3197nt_BP=48nt
ATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGTAAACCAGACTTGAATACAACATTGCCAATTAGACAAACA
GCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGAACAGCCA
CGTCAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGAACTACCCAAAGGT
CTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAATCACAGGG
CAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGTCACAGATGAAGAC
ATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGCTGATACA
GAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCCAAGAGAAAATTCC
TAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTAATAGCACTAACCA
ATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAAAATTAGTCTTTTG
TAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGTAAAACATTTGTTT
CCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTATATAAACATATTT
TTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAGACTGATTGGAATT
CTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGGGCCTTAGGTTTGA
CATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTCACCAGAATTTCTA
AGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATAAGAATAAGGCTTT
TTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTTAAAGAATGTTTGG
CACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTAGACAGAGTTGCTT
AATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCTGTTGAAACTCGCG
AGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAAAATCAAAACATAC
TTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAAATCATTCTATAGA
AAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAATTCCACATGAGTGT
CACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACTAGCTAGGTTTGGG
CTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGCTCAACTTTGATCC
CTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAGCCAATTGGTAGAG
GGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGTATGACTAGTGAGA
ATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCACCTTGGTGATCAT
ATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTATACACATATAAAA
CTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTGGGGACCATCCCAT
AAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCACCCTCTTCCATTCC
CTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTTCCCTTGCTTCTGA
CTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAACTGCCTTTCCTGT
CCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACATAGTCATCAGAAAG
ATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAGCACACACTTTGAA
ATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTGTCCCTCCTCAGTG
AAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGCACAGTGCCTGGCA

>58422_58422_1_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000256830_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=193AA_BP=16
MATGLGEPVYGLSEDEGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKG
LQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADT

--------------------------------------------------------------
>58422_58422_2_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000356462_MBD2_chr18_51715381_ENST00000256429_length(transcript)=3491nt_BP=342nt
GCGCCGCCGCCGCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGC
CTTCCGGGAGGAAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGT
GCGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCA
GACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGTAAACCAGACTTGAAT
ACAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGAC
CCACAACGAATGAATGAACAGCCACGTCAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATA
AAAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCAC
ACAAGCTCTGCGCCAATCACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAA
GCTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGAC
ATCTTGTCGCGAGCTGCTGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGAC
CGACTTTCCCCAAGAGAAAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACAT
AGAGCTTTTTAATAGCACTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTC
CTAGGACTTAAAATTAGTCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGT
AGCACTTACGTAAAACATTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTG
ACTTCACTGTATATAAACATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGAT
TATATTCACAGACTGATTGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACT
CTGATCCCTGGGCCTTAGGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGA
ATTGTGCTTTCACCAGAATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTG
ATAGTTCTATAAGAATAAGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTT
TATTGTTTTTTAAAGAATGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGA
GGCAGCTTCTAGACAGAGTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAAC
ATTCTTTTTCTGTTGAAACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAA
ACGATTTCTAAAATCAAAACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGA
GCAAAAGTAAAATCATTCTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGG
GTATGACCAATTCCACATGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAA
GCAATATGACTAGCTAGGTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTC
CTGATTTACGCTCAACTTTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAG
ACCCTGGGAAGCCAATTGGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTT
TAAAAGCTAGTATGACTAGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTG
GGGTAACTTCACCTTGGTGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAA
AACACAATGTATACACATATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATAT
GGTGTCCCTTGGGGACCATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCAC
AAACCTACCACCCTCTTCCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAA
TGCTGCCCTTTCCCTTGCTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGC
CTTCATATGAACTGCCTTTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCA
TCCCTCCACATAGTCATCAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTG
ATTTTTAAGAGCACACACTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCT
CTTTGAGCCTGTCCCTCCTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTA

>58422_58422_2_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000356462_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=221AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQ
LFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIR

--------------------------------------------------------------
>58422_58422_3_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000382850_MBD2_chr18_51715381_ENST00000256429_length(transcript)=3310nt_BP=161nt
CGCAGGGTAGGGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAG
ACCCCGCGCGGGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGTAAACCAGACTTGAATA
CAACATTGCCAATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACC
CACAACGAATGAATGAACAGCCACGTCAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAA
AAACCATGGAACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACA
CAAGCTCTGCGCCAATCACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAG
CTTTTATTGTCACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACA
TCTTGTCGCGAGCTGCTGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACC
GACTTTCCCCAAGAGAAAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATA
GAGCTTTTTAATAGCACTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCC
TAGGACTTAAAATTAGTCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTA
GCACTTACGTAAAACATTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGA
CTTCACTGTATATAAACATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATT
ATATTCACAGACTGATTGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTC
TGATCCCTGGGCCTTAGGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAA
TTGTGCTTTCACCAGAATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGA
TAGTTCTATAAGAATAAGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTT
ATTGTTTTTTAAAGAATGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAG
GCAGCTTCTAGACAGAGTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACA
TTCTTTTTCTGTTGAAACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAA
CGATTTCTAAAATCAAAACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAG
CAAAAGTAAAATCATTCTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGG
TATGACCAATTCCACATGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAG
CAATATGACTAGCTAGGTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCC
TGATTTACGCTCAACTTTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGA
CCCTGGGAAGCCAATTGGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTT
AAAAGCTAGTATGACTAGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGG
GGTAACTTCACCTTGGTGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAA
ACACAATGTATACACATATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATG
GTGTCCCTTGGGGACCATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACA
AACCTACCACCCTCTTCCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAAT
GCTGCCCTTTCCCTTGCTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCC
TTCATATGAACTGCCTTTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCAT
CCCTCCACATAGTCATCAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGA
TTTTTAAGAGCACACACTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTC
TTTGAGCCTGTCCCTCCTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAA

>58422_58422_3_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000382850_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=221AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQ
LFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIR

--------------------------------------------------------------
>58422_58422_4_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000400345_MBD2_chr18_51715381_ENST00000256429_length(transcript)=3480nt_BP=331nt
GCGCGCAGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGG
AAGCGGTGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAG
GGTGCGGGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCG
GGGCGCCGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGTAAACCAGACTTGAATACAACATTGCC
AATTAGACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAAT
GAATGAACAGCCACGTCAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGA
ACTACCCAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGC
GCCAATCACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGT
CACAGATGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCG
AGCTGCTGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCC
AAGAGAAAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTA
ATAGCACTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAA
AATTAGTCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGT
AAAACATTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTA
TATAAACATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAG
ACTGATTGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGG
GCCTTAGGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTC
ACCAGAATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATA
AGAATAAGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTT
AAAGAATGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTA
GACAGAGTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCT
GTTGAAACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAA
AATCAAAACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAA
ATCATTCTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAAT
TCCACATGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACT
AGCTAGGTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGC
TCAACTTTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAG
CCAATTGGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGT
ATGACTAGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCA
CCTTGGTGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTA
TACACATATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTG
GGGACCATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCAC
CCTCTTCCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTT
CCCTTGCTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAA
CTGCCTTTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACAT
AGTCATCAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAG
CACACACTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTG
TCCCTCCTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGC

>58422_58422_4_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000400345_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=221AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQ
LFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIR

--------------------------------------------------------------
>58422_58422_5_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000589054_MBD2_chr18_51715381_ENST00000256429_length(transcript)=3474nt_BP=325nt
AGTGAGAGGCGCCGGGGCTGCCGCCCGGTGCTCGGCGCGCTCTCGGGAGCCGCCCGCCCGCTGGTCCCGCAGCCTTCCGGGAGGAAGCGG
TGCCGGCAGCGTCCAGGGCGCGCTCTCGGGCACCCTCACCTGCCGGCGCCCGGCCGCTTACCCGGCAGGGCGTGCGCAGGGTAGGGTGCG
GGACCGGGGGGACCTGGAGGCAGAGGGGAGAACCGGCCGTCCGCGCCGCAGCACAGCCGCTGGGAGCGCCTCAGACCCCGCGCGGGGCGC
CGGCTCCATGGCGACCGGGCTCGGGGAGCCGGTCTATGGACTTTCCGAAGACGAGGGTAAACCAGACTTGAATACAACATTGCCAATTAG
ACAAACAGCATCAATTTTCAAACAACCGGTAACCAAAGTCACAAATCATCCTAGTAATAAAGTGAAATCAGACCCACAACGAATGAATGA
ACAGCCACGTCAGCTTTTCTGGGAGAAGAGGCTACAAGGACTTAGTGCATCAGATGTAACAGAACAAATTATAAAAACCATGGAACTACC
CAAAGGTCTTCAAGGAGTTGGTCCAGGTAGCAATGATGAGACCCTTTTATCTGCTGTTGCCAGTGCTTTGCACACAAGCTCTGCGCCAAT
CACAGGGCAAGTCTCCGCTGCTGTGGAAAAGAACCCTGCTGTTTGGCTTAACACATCTCAACCCCTCTGCAAAGCTTTTATTGTCACAGA
TGAAGACATCAGGAAACAGGAAGAGCGAGTACAGCAAGTACGCAAGAAATTGGAAGAAGCACTGATGGCAGACATCTTGTCGCGAGCTGC
TGATACAGAAGAGATGGATATTGAAATGGACAGTGGAGATGAAGCCTAAGAATATGATCAGGTAACTTTCGACCGACTTTCCCCAAGAGA
AAATTCCTAGAAATTGAACAAAAATGTTTCCACTGGCTTTTGCCTGTAAGAAAAAAAATGTACCCGAGCACATAGAGCTTTTTAATAGCA
CTAACCAATGCCTTTTTAGATGTATTTTTGATGTATATATCTATTATTCAAAAAATCATGTTTATTTTGAGTCCTAGGACTTAAAATTAG
TCTTTTGTAATATCAAGCAGGACCCTAAGATGAAGCTGAGCTTTTGATGCCAGGTGCAATCTACTGGAAATGTAGCACTTACGTAAAACA
TTTGTTTCCCCCACAGTTTTAATAAGAACAGATCAGGAATTCTAAATAAATTTCCCAGTTAAAGATTATTGTGACTTCACTGTATATAAA
CATATTTTTATACTTTATTGAAAGGGGACACCTGTACATTCTTCCATCATCACTGTAAAGACAAATAAATGATTATATTCACAGACTGAT
TGGAATTCTTTCTGTTGAAAAGCACACACAATAAAGAACCCCTCGTTAGCCTTCCTCTGATTTACATTCAACTCTGATCCCTGGGCCTTA
GGTTTGACATGGAGGTGGAGGAAGATAGCGCATATATTTGCAGTATGAACTATTGCCTCTGGACGTTGTGAGAATTGTGCTTTCACCAGA
ATTTCTAAGAATTTCTGCTAAATATCACCTAGCATGTGTAATTTTTTTTCCTTGCCTGTGACTTGGACTTTTGATAGTTCTATAAGAATA
AGGCTTTTTCTTCCCTTGGGCATGAGTCAGATACACAAGGACCCTTCAGGTGTTACTAGAAGGCGTCCATGTTTATTGTTTTTTAAAGAA
TGTTTGGCACTCTCTAACGTCCACTAGCTTACTGAGTTATCAGGTGCAGGTCAGACTCTTGGCTACAGTGAGAGGCAGCTTCTAGACAGA
GTTGCTTAATGAAAGGGTTTGTAATACTTTACAAACCATTACCTGTACCTGGCCTGGCCTCCAAAATATTAACATTCTTTTTCTGTTGAA
ACTCGCGAGTGTAACTTTCATACCACTTGAATTTATTGATATTTAATTATGAAAACTAGCATTACATTATTAAACGATTTCTAAAATCAA
AACATACTTAATCTGATACCAAGGAAGGGAGGGAGTGGTTATAAGCAAATGAAAACAAATTTTGAGAGACAGAGCAAAAGTAAAATCATT
CTATAGAAAAGGTGTGTTTATTTCTTAACTCTTGAGTTCTTTTAAAATTAGAACCTAAATGATGCAGTCAGGGGTATGACCAATTCCACA
TGAGTGTCACCTGTACATTTTATTACCACTACCTCCAGTTTCCAAGGCAGGGAAGAAGAGGGGAATAGTCAAAGCAATATGACTAGCTAG
GTTTGGGCTGCTGTTTGGGCTGCTGTTTTTCCTGGACTTTTATGCCAAACTACATAAATACTTCTTGGAATTCCTGATTTACGCTCAACT
TTGATCCCTGGACCCTAGGGCCATTAGTTTCCTTGAAGCAGTCCTGCTGGTGGATGAGCAGGGAAACTTGTAGACCCTGGGAAGCCAATT
GGTAGAGGGTGCCTGCCCGCCCCATCAGACTGTCCCAACTGGGGTGGGGGTGAGGATCATAGTGATTTCTTTTTAAAAGCTAGTATGACT
AGTGAGAATGGATGTCCAAGGGCTTTTCTCTTCCTCCCCCGAGTCCACGATTCTTCATTTGTGATCAGGGTTGGGGTAACTTCACCTTGG
TGATCATATATTCTTTTTACAAACCAATCCAGCCAAGATATATGTGCTTTTCTAAACAGCTTGTAAAAGCAAAAACACAATGTATACACA
TATAAAACTGATTTTTTTTTTTTTGCTTATATACTTTGCTCAGGTGGAGAACAAGGTATGAAAGCCATTATATGGTGTCCCTTGGGGACC
ATCCCATAAGTCCAGGGTGTTCCCAATATACCCACAAGACAACATGTTCAAAACTTCATCACCTGGTCCCCACAAACCTACCACCCTCTT
CCATTCCCTCACTCTGGTAAAAGCAAGCCATCTTCTCCAGTTACGCAAGGCAGAAGCCCAGGAGTGAGCACAATGCTGCCCTTTCCCTTG
CTTCTGACTTCTCATCAATCCTATTAGAACTACTGACTGCACCCCACCTCTCCTCCATCCCCACGATCACTGCCTTCATATGAACTGCCT
TTCCTGTCCTCTGGACTTTCAGTGGCTTCCTTTTTTGCTCACCTGTCCACTTTCTTCCCCTTCCCTCTCTCCATCCCTCCACATAGTCAT
CAGAAAGATCATCAAAACAGGCAAATGTGACTGTATTATTTCCCTCACTTATCTTTGTATGCAGTTTAGAGTGATTTTTAAGAGCACACA
CTTTGAAATTAGGAGAACCTGTGTCTGAATCCTGATTTTTGCCATTTGTGTGACTTGTCAGGTTATTTAATCTCTTTGAGCCTGTCCCTC
CTCAGTGAAATAGGAATAATAATACCTACCTCATAGAGTTGTTGTGAGGATTCAGTGAGATAGACTGTTTCTAAAGTGTGTAGCACAGTG

>58422_58422_5_NEDD4L-MBD2_NEDD4L_chr18_55711940_ENST00000589054_MBD2_chr18_51715381_ENST00000256429_length(amino acids)=221AA_BP=44
MEAEGRTGRPRRSTAAGSASDPARGAGSMATGLGEPVYGLSEDEGKPDLNTTLPIRQTASIFKQPVTKVTNHPSNKVKSDPQRMNEQPRQ
LFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIR

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Fusion Gene PPI Analysis for NEDD4L-MBD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NEDD4L-MBD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NEDD4L-MBD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneNEDD4LC0020538Hypertensive disease2CTD_human
HgeneNEDD4LC4310669PERIVENTRICULAR NODULAR HETEROTOPIA 72GENOMICS_ENGLAND;UNIPROT
HgeneNEDD4LC0008925Cleft Palate1CTD_human;GENOMICS_ENGLAND
HgeneNEDD4LC0014175Endometriosis1CTD_human
HgeneNEDD4LC0039075Syndactyly1CTD_human
HgeneNEDD4LC0265553Polysyndactyly1CTD_human
HgeneNEDD4LC0269102Endometrioma1CTD_human
HgeneNEDD4LC0543888Epileptic encephalopathy1GENOMICS_ENGLAND
HgeneNEDD4LC1837218Cleft palate, isolated1CTD_human
HgeneNEDD4LC1848213Periventricular Heterotopia, X-Linked1CTD_human
HgeneNEDD4LC1868720Periventricular Nodular Heterotopia1CTD_human;ORPHANET
HgeneNEDD4LC4551969Bilateral Periventricular Nodular Heterotopia1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC2931456Prostate cancer, familial1CTD_human
TgeneC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human