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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF12-KPNA1 (FusionGDB2 ID:HG23365TG3836)

Fusion Gene Summary for ARHGEF12-KPNA1

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF12-KPNA1
Fusion gene ID: hg23365tg3836
HgeneTgene
Gene symbol

ARHGEF12

KPNA1

Gene ID

23365

3836

Gene nameRho guanine nucleotide exchange factor 12karyopherin subunit alpha 1
SynonymsLARG|PRO2792IPOA5|NPI-1|RCH2|SRP1
Cytomap('ARHGEF12')('KPNA1')

11q23.3

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor (GEF) 12leukemia-associated RhoGEFleukemia-associated rho guanine nucleotide exchange factorimportin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2
Modification date2020031320200313
UniProtAcc

Q9NZN5

.
Ensembl transtripts involved in fusion geneENST00000356641, ENST00000397843, 
ENST00000532993, 
Fusion gene scores* DoF score16 X 13 X 9=18723 X 3 X 2=18
# samples 213
** MAII scorelog2(21/1872*10)=-3.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ARHGEF12 [Title/Abstract] AND KPNA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF12(120308091)-KPNA1(122156142), # samples:1
Anticipated loss of major functional domain due to fusion event.ARHGEF12-KPNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-KPNA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-KPNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF12-KPNA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF12

GO:0007186

G protein-coupled receptor signaling pathway

15755723


check buttonFusion gene breakpoints across ARHGEF12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KPNA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8525-01AARHGEF12chr11

120308091

+KPNA1chr3

122156142

-


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Fusion Gene ORF analysis for ARHGEF12-KPNA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000356641ENST00000466923ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-
5CDS-5UTRENST00000397843ENST00000466923ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-
5CDS-5UTRENST00000532993ENST00000466923ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-
In-frameENST00000356641ENST00000344337ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-
In-frameENST00000397843ENST00000344337ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-
In-frameENST00000532993ENST00000344337ARHGEF12chr11

120308091

+KPNA1chr3

122156142

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000397843ARHGEF12chr11120308091+ENST00000344337KPNA1chr3122156142-682211651661785539
ENST00000356641ARHGEF12chr11120308091+ENST00000344337KPNA1chr3122156142-660694971569520
ENST00000532993ARHGEF12chr11120308091+ENST00000344337KPNA1chr3122156142-681711602301780516

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397843ENST00000344337ARHGEF12chr11120308091+KPNA1chr3122156142-0.0002069060.9997931
ENST00000356641ENST00000344337ARHGEF12chr11120308091+KPNA1chr3122156142-0.0002117040.99978834
ENST00000532993ENST00000344337ARHGEF12chr11120308091+KPNA1chr3122156142-0.0002115990.99978846

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Fusion Genomic Features for ARHGEF12-KPNA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGEF12-KPNA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:120308091/chr3:122156142)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGEF12

Q9NZN5

.
FUNCTION: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. {ECO:0000269|PubMed:11094164}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000356641+1140194_2623141526.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000397843+1241194_2623331545.0Coiled coilOntology_term=ECO:0000255
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000356641+114072_1513141526.0DomainPDZ
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000397843+124172_1513331545.0DomainPDZ
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914331_372332539.0RepeatNote=ARM 7
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914373_412332539.0RepeatNote=ARM 8
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914413_457332539.0RepeatNote=ARM 9
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914460_504332539.0RepeatNote=ARM 10%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000356641+11401019_11323141526.0DomainPH
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000356641+1140367_5583141526.0DomainNote=RGSL
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000356641+1140787_9773141526.0DomainDH
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000397843+12411019_11323331545.0DomainPH
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000397843+1241367_5583331545.0DomainNote=RGSL
HgeneARHGEF12chr11:120308091chr3:122156142ENST00000397843+1241787_9773331545.0DomainDH
TgeneKPNA1chr11:120308091chr3:122156142ENST0000034433791425_28332539.0Compositional biasNote=Poly-Arg
TgeneKPNA1chr11:120308091chr3:122156142ENST000003443379141_57332539.0DomainIBB
TgeneKPNA1chr11:120308091chr3:122156142ENST0000034433791442_51332539.0MotifNuclear localization signal
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914149_241332539.0RegionNLS binding site (major)
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914245_437332539.0RegionNote=Binding to RAG1
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914318_406332539.0RegionNLS binding site (minor)
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914118_161332539.0RepeatNote=ARM 2
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914162_206332539.0RepeatNote=ARM 3
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914207_245332539.0RepeatNote=ARM 4
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914246_290332539.0RepeatNote=ARM 5
TgeneKPNA1chr11:120308091chr3:122156142ENST00000344337914291_330332539.0RepeatNote=ARM 6
TgeneKPNA1chr11:120308091chr3:122156142ENST0000034433791477_117332539.0RepeatNote=ARM 1%3B truncated


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Fusion Gene Sequence for ARHGEF12-KPNA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6211_6211_1_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000356641_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6606nt_BP=949nt
GGCCCCAATGAGTGGCACACAGTCTACTATCACCGACAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTC
ACCAACAGATAAGAAGCAGAAAGTTGAGCGCATTGCATCACATGATTTTGACCCCACAGGTCTTGTTCAGCGTTGCGTAATCATCCAGAA
AGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACAGTCTGTCAAAGAAGATGGAGCAGCCATGCGGGCTGG
AGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTCAAATCATCTGGAGGTGGTGAAGCTAATCAAATCTGG
TTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCCACTTGCCGACTCTGAAGTAGAGCCGTCAGTCATTGG
ACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATATGGAGAGAATCACTAGTCCTGTGCTCATGGGGGAGGA
AAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAAAGAACAGGAACGGCTACAGTTATTGCAGGAAGATTA
CAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACACATTCCTCAGCTGCAAGAGCAGTTATCCAAAGCCAC
AGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACACCCTAACAGTCAGTGAGGCAGAAACAGATCCTGGAGA
TGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGACAATGCAGATAGTCCCAAGAGTGGCCCAAAAGAGAG
AATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAATTCTGAATTGCTCAGCTCTGCAGAGTTTATTGCATTT
GCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAATATTACAGCTGGAAATAGGGCACAGATCCAGACTGT
GATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATTTCGGACAAGAAAAGAAGCAGCTTGGGCCATCACAAA
TGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTGTATCAAGCCGCTCTGTGATCTCCTCACGGTCATGGA
CTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGGAGAACAGGAAGCCAAAAGGAATGGCACTGGCATTAA
CCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTTACAGAGTCATGAAAACCAGGAGATCTACCAAAAGGC
CTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGCACCCCAGGTTGACCTTAACCAGCAGCAGTACATCTT
CCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCTTTCACGTACCTGTGTCAGACCAGGCTACCCAGTCGA
GTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCATAATACTGTTTGCGCTCATTTGCTTGCCTTGCGCAC
CTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCTTCTAATAAAAGGGTAACCAGAACGGCCCACTCTCTT
TTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGAATATACACATATTAATGTGGCTCCCTTTTTCTTGTG
GGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGACATTAAAAGATGAGACTAAATCTTTATCTTGAATTT
TACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGAGTACTTTTCATGAGTTCTTCCACAGTGAACCCTTGG
ATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGATGGTTTTCTTTCCTCTATTGGCGCCATTCTTCAGAT
ATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTCTAGTTGTCAGGAATGCTGAAGAATTAACACTTTGAC
TCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCACATATTAATTTGTATCGCTTTTGCTTCTCTTTGGTC
TTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTTCGAATACTTAGTAATCGAAAACCATATCCTGTAATT
TAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAGTGTAACTAGGGGCTGTGTTTCTGCATTAAAATAAAT
GTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACCCTAGGTGCTTTTCCCCTCTGTGACTGGCAGATAACA
CATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAATCTTTTCATGCTGCACACGATTCCTTTAATGTAGCA
TCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATAAGAACAGTGATCTTATAACCTCATTGTTTCCTAATC
ATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAAATAAAAACAGTATCTGCCTTCTGGCTCATTTAATGA
TGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCACATTTGTGCTTGGACTGGAATGAAAAAATACGCTTA
ATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCCATCTTGACTCAATGTTGGGATACACTACCAGAGAAG
ATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCACCTCTGTTTCAGAGCATACCCTTTTAAACCTTTTTAG
ACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAAGTTGCCCCTGACAAGCTATTATACATCTCTGGTAAA
TCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTATTTAAGCAGCCAACTTATGTGACCTGATTTAAACTTT
TAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATCAGCCAAGAGTGTGACGCATTCTTCGCATCTAGTCTG
TAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGATGGCGCAGCCACTGCAAAACTAGTCAACTCCCATCTA
TAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACTGCACTTGACCTGTAAAAGACTGATTCTTTGTAATTT
TAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACATCACATTAAAATATAACTTCTTTCAGAAGGATAATA
GAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCTGTTTTTTAAAATTGTAAATTACTAGTAACATGTCAT
TTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTCATTTTATAAGCCAATTTGAGTGGGAAAGATACAAAG
CACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAATTTTTGCTAGTAGTTGGAGATGTTTCAGTGAGTGAA
TTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGAATTTATCTTGTCCTAGAAGTTCATGAACTATAAGAT
CTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAAGTTGGAATTGGCTAAAAGTGAAGTAGCATAACTCAG
ATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTTAAGGGGTAACTGTATATCCTGTTTTTAGTTCTTTGC
CTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGCGTTGCTCATTACAAAAGCATGTTAATTTCAATACAG
GAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACTTTTCCTTTTTATTCCCCTCCATCCTCCAAACTTCCA
ATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAATTTTGGATGTAAAGGCATCTGGTATCTGATGGACCA
GCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAAAGAGATTTTAGGAGACACAGTTCTCTGTGGAACACT
TTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTTGTCAGTTCCGCTTTTGAAAAAACTATTGCCCTAGGA
TTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCATTATCGTCACAGATAAAAAGATTGGCAATTAATCTCA
TAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATATGTAAGTATATTTTATAAACCAAACTTTGTCAACCAA
TTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAATAAACATTTCAGCGATTTAATCCCCCAACTTGGGGG
ATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTTTTGTGAAAATTTTTATATCAATAGGCAAATCATTAT
AACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGGATGATGTTCAGTGAAGAAAAGGGATCCACTTTTAGA
AACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCAAAATGTGCTCATTTGCAGACACAGGTATGCCTATAT
ACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTCTGTTGTGAGCTGAACAGATTAAGTATATATCTGCCA
GGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAAAATTATCAAAGGTCAGATGTGACTACTACAGTAAGT
TGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACTGGGTTTATGGCCGGATGTGGTGGCTCATGCCTGTAA
TCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGGACATCAGAATATCTGATAAAGCAAATATTTATATGC
TAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGGTAAGAAGAAAGAAAAGAAGTGTTCCGTTCTGTTTTC
AACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTAACATGTCTTTATTTGATCATCTATTGTACACCAGAT
ACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGATAATTGTCACTATATTATAGATGACAAAGTGAAGACT
TACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGCGGGGAAGAGCCCTGCAAATTCTGTGTCTTGAAGAAA
GCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCAACCACAGCTGGGCCAGCCTTTTTTGTTAGACCATTC
TTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAGTTGCTTTTAGGTTACACAGACTGGAGTGTAGGCCCT
CTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGACAAGTATGGTAATAGGTTTTTTTTTTTTTTTTTTTTG
TGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAAACGCACAAATGTGGAAAGTATTGACACGGAAGGAAA
GGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACACAGTCTACTTCTTCCTAAAGGAATATCATCCCAAGGA
ATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTTTACCTCAAGTCATTCTGACCACTCTACATCCTGCTT
CAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGAATGTGGTCTGTCAGGCCATGGGTGAGTGCCTTGCAC

>6211_6211_1_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000356641_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=520AA_BP=314
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQ
TGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENN
VVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVL
GRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVID
ANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPY

--------------------------------------------------------------
>6211_6211_2_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000397843_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6822nt_BP=1165nt
GTTGACCCCTTACAGTCGGATGGTCTAGATGACTGAATGGAGTTTTGAGTTGGACTTTTGTGTCCCTGACGGAGTTGGGCCTGATCCCAG
AGCACTGGGGGTGGGGAGGAGGTGTTACTGTAAAATGCAAGTTGGATAAAAGGAGGACCTCTCGCCAAGGGCCCCAATGAGTGGCACACA
GTCTACTATCACCGACAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTCACCAACAGATAAGAAGCAGAA
AGTTGAGCGCATTGCATCACATGATTTTGACCCCACAGATAGCTCCTCCAAGAAGACAAAGTCTAGTTCAGAGGAGAGTAGATCCGAGAT
ATATGGTCTTGTTCAGCGTTGCGTAATCATCCAGAAAGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACA
GTCTGTCAAAGAAGATGGAGCAGCCATGCGGGCTGGAGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTC
AAATCATCTGGAGGTGGTGAAGCTAATCAAATCTGGTTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCC
ACTTGCCGACTCTGAAGTAGAGCCGTCAGTCATTGGACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATAT
GGAGAGAATCACTAGTCCTGTGCTCATGGGGGAGGAAAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAA
AGAACAGGAACGGCTACAGTTATTGCAGGAAGATTACAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACA
CATTCCTCAGCTGCAAGAGCAGTTATCCAAAGCCACAGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACAC
CCTAACAGTCAGTGAGGCAGAAACAGATCCTGGAGATGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGA
CAATGCAGATAGTCCCAAGAGTGGCCCAAAAGAGAGAATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAAT
TCTGAATTGCTCAGCTCTGCAGAGTTTATTGCATTTGCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAA
TATTACAGCTGGAAATAGGGCACAGATCCAGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATT
TCGGACAAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTG
TATCAAGCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGG
AGAACAGGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTT
ACAGAGTCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGC
ACCCCAGGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCT
TTCACGTACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCA
TAATACTGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCT
TCTAATAAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGA
ATATACACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGA
CATTAAAAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGA
GTACTTTTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGA
TGGTTTTCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTC
TAGTTGTCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCA
CATATTAATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTT
CGAATACTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAG
TGTAACTAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACC
CTAGGTGCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAA
TCTTTTCATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATA
AGAACAGTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAA
ATAAAAACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCA
CATTTGTGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCC
ATCTTGACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCAC
CTCTGTTTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAA
GTTGCCCCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTAT
TTAAGCAGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATC
AGCCAAGAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGAT
GGCGCAGCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACT
GCACTTGACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACA
TCACATTAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCT
GTTTTTTAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTC
ATTTTATAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAA
TTTTTGCTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGA
ATTTATCTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAA
GTTGGAATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTT
AAGGGGTAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGC
GTTGCTCATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACT
TTTCCTTTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAA
TTTTGGATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAA
AGAGATTTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTT
GTCAGTTCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCAT
TATCGTCACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATAT
GTAAGTATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAA
TAAACATTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTT
TTGTGAAAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGG
ATGATGTTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCA
AAATGTGCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTC
TGTTGTGAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAA
AATTATCAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACT
GGGTTTATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGG
ACATCAGAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGG
TAAGAAGAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTA
ACATGTCTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGAT
AATTGTCACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGC
GGGGAAGAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCA
ACCACAGCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAG
TTGCTTTTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGAC
AAGTATGGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAA
ACGCACAAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACAC
AGTCTACTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTT
TACCTCAAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGA

>6211_6211_2_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000397843_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=539AA_BP=333
MSGTQSTITDRFPLKKPIRHGSILNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDN
PVFVQSVKEDGAAMRAGVQTGDRIIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPG
ASGNMERITSPVLMGEENNVVHNQKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSR
PLGDTLTVSEAETDPGDVLGRTDCSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEAC
WTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLEN

--------------------------------------------------------------
>6211_6211_3_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000532993_KPNA1_chr3_122156142_ENST00000344337_length(transcript)=6817nt_BP=1160nt
CTTCTTATCATCCCTCTTGTGGTCAGTAAAATCATCTGACAAATGCCTTTCCAAGGATGTCGAATGTATATATAAAGAAAAAGCTTAGGA
TTGCTAAGGGAGTGGTATTTTGGTGAGGATTTCATTTTCTTCTACTCCATGGAAACGAGCCTTTTGAGCTTTTGCTTGTCTGCTGATTTG
TCCGGTGATCCAGGTTTCCCCTCAAAAAACCTATAAGGCATGGAAGTATTTTGAACCGAGAGTCACCAACAGATAAGAAGCAGAAAGTTG
AGCGCATTGCATCACATGATTTTGACCCCACAGATAGCTCCTCCAAGAAGACAAAGTCTAGTTCAGAGGAGAGTAGATCCGAGATATATG
GTCTTGTTCAGCGTTGCGTAATCATCCAGAAAGATGACAATGGATTTGGGCTGACGGTCAGTGGAGACAATCCAGTCTTCGTACAGTCTG
TCAAAGAAGATGGAGCAGCCATGCGGGCTGGAGTACAGACAGGTGATCGAATCATCAAGGTGAATGGAACTCTGGTGACTCATTCAAATC
ATCTGGAGGTGGTGAAGCTAATCAAATCTGGTTCCTATGTAGCTCTCACTGTTCAGGGACGCCCACCTGGGTCGCCCCAGATTCCACTTG
CCGACTCTGAAGTAGAGCCGTCAGTCATTGGACATATGTCTCCCATCATGACATCTCCTCATTCACCTGGAGCATCTGGGAATATGGAGA
GAATCACTAGTCCTGTGCTCATGGGGGAGGAAAACAATGTGGTTCATAACCAGAAAGTAGAAATTCTGAGAAAAATGTTACAGAAAGAAC
AGGAACGGCTACAGTTATTGCAGGAAGATTACAACCGAACACCTGCCCAAAGATTGCTAAAAGAGATCCAAGAGGCCAAGAAACACATTC
CTCAGCTGCAAGAGCAGTTATCCAAAGCCACAGGCTCTGCTCAGGATGGAGCTGTAGTTACACCCTCCAGACCTTTAGGGGACACCCTAA
CAGTCAGTGAGGCAGAAACAGATCCTGGAGATGTACTGGGCAGGACTGACTGTAGCAGTGGAGATGCTTCTCGGCCCAGTAGTGACAATG
CAGATAGTCCCAAGAGTGGCCCAAAAGAGAGAATTTATCTAGAGGAAAACCCAGAGAAAAGTGAAACAATTCAGGACACTGTAATTCTGA
ATTGCTCAGCTCTGCAGAGTTTATTGCATTTGCTGAGTAGCCCAAAGGAATCTATCAAAAAGGAAGCATGTTGGACGATATCTAATATTA
CAGCTGGAAATAGGGCACAGATCCAGACTGTGATAGATGCCAACATTTTCCCAGCCCTCATTAGTATTTTACAAACTGCTGAATTTCGGA
CAAGAAAAGAAGCAGCTTGGGCCATCACAAATGCAACTTCTGGAGGATCAGCTGAACAGATCAAGTACCTAGTAGAACTGGGTTGTATCA
AGCCGCTCTGTGATCTCCTCACGGTCATGGACTCTAAGATTGTACAGGTTGCCCTAAATGGCTTGGAAAATATCCTGAGGCTTGGAGAAC
AGGAAGCCAAAAGGAATGGCACTGGCATTAACCCTTACTGTGCTTTGATTGAAGAAGCTTATGGTCTGGATAAAATTGAGTTCTTACAGA
GTCATGAAAACCAGGAGATCTACCAAAAGGCCTTTGATCTTATTGAGCATTACTTCGGGACCGAAGATGAAGACAGCAGCATTGCACCCC
AGGTTGACCTTAACCAGCAGCAGTACATCTTCCAACAGTGTGAGGCTCCTATGGAAGGTTTCCAGCTTTGAAGCAATACTCTGCTTTCAC
GTACCTGTGTCAGACCAGGCTACCCAGTCGAGTCCTCTTGTGGAGCCCACAGTCCTCATGGAGCTAACTTCTCAAATGTTTTCCATAATA
CTGTTTGCGCTCATTTGCTTGCCTTGCGCACCTGCTCTCTTACACACATCTGGAAAACCTCCGGCTCTCTGTGGTGGAATACCCTTCTAA
TAAAAGGGTAACCAGAACGGCCCACTCTCTTTTACGGAAAAATCCCTAGGCTTTGGAGATCCGCACTTACATTAGAGTTATGGGAATATA
CACATATTAATGTGGCTCCCTTTTTCTTGTGGGGGAATAAAAGAGGACTCCTCCTCATTCCCTTTAACATGGGGGAAAAAACTGACATTA
AAAGATGAGACTAAATCTTTATCTTGAATTTTACACAACTACTTACGACAAGGGAGATGTTTAGACCTGTTGTGTATACTTCAGAGTACT
TTTCATGAGTTCTTCCACAGTGAACCCTTGGATTACCTGGTGGCTTTTTCTAGCCAGATTTGCATTAATCCTTACTGAGATTGGATGGTT
TTCTTTCCTCTATTGGCGCCATTCTTCAGATATTAAAGTTAAACCATCCACTCCCTCACCTTCAGCCTTCAGTGAATGTGCTTTCTAGTT
GTCAGGAATGCTGAAGAATTAACACTTTGACTCCTAAATGTGATACTGGTTTGTAGATTCCCTTAGAGCAGAAAGGAGAGGGGCACATAT
TAATTTGTATCGCTTTTGCTTCTCTTTGGTCTTTTGTGTCTTAGAATTTGGAAGTGGTTCATTTCTGTTGCTGGTATGAGGATTTCGAAT
ACTTAGTAATCGAAAACCATATCCTGTAATTTAATAAAAAAAACTAAGGACGAAAAAACCCTCCAATTTTCCCAAATGCAATCAGTGTAA
CTAGGGGCTGTGTTTCTGCATTAAAATAAATGTTTCAGGCTTTGTGGTCCTGATCAAGGTCCTCATTAAAAAATTGGAGTTCACCCTAGG
TGCTTTTCCCCTCTGTGACTGGCAGATAACACATACTTTTGAAAGTAACTTTGGGATTTTTTTCTTAGGTGCAGCTCGATTCTAATCTTT
TCATGCTGCACACGATTCCTTTAATGTAGCATCCTTATCTGAAAGAAATAACCATCTTCTCAACATGACCTGCTTAACCCAAATAAGAAC
AGTGATCTTATAACCTCATTGTTTCCTAATCATTTTATTTCATCTCCTGCTAGTACTGTGCCGCTTCCCCCTCCCCCCACACAAAATAAA
AACAGTATCTGCCTTCTGGCTCATTTAATGATGACTGCAATCTGTACCTGCAAATGGCGCTTCCAGTACTGTGTTCAGTGATCCACATTT
GTGCTTGGACTGGAATGAAAAAATACGCTTAATTGCCAAGACAACTGCAAATGAGTTCAATACGACTTCTCGGTGCTAGTTGGCCATCTT
GACTCAATGTTGGGATACACTACCAGAGAAGATTTTTTTGTTGATGTGCTGTTCAAAGTGAATTCTGAAGGAAAAGGTTGCTCACCTCTG
TTTCAGAGCATACCCTTTTAAACCTTTTTAGACTTGTCCTCTTCTAGAATTCATTATAACCCCAAAGTGTAAAAACTATTTGGAAGTTGC
CCCTGACAAGCTATTATACATCTCTGGTAAATCCTGCTGAATGTAAGGGATATTCAGAGCTTTTCATACCTCATCATGATGTTATTTAAG
CAGCCAACTTATGTGACCTGATTTAAACTTTTAAAAAATCCACTTCATTCAAACTAGAAAGAGTCAAAGACAAAGGACATTTATCAGCCA
AGAGTGTGACGCATTCTTCGCATCTAGTCTGTAGTAGTGTCTGTGCTCTGGGATGGATACCGTCTGATGTCTGTTTGTTATTGATGGCGC
AGCCACTGCAAAACTAGTCAACTCCCATCTATAACTGTTACTTTTTCTAGTGCTGCTTTGTGCTGAGAGAACATTTTAGTTTACTGCACT
TGACCTGTAAAAGACTGATTCTTTGTAATTTTAGGGATAAATTAGGTGGTTAATTTAAAGAAGAAATTTCAATGTTGCCTTTACATCACA
TTAAAATATAACTTCTTTCAGAAGGATAATAGAAGCACTGATTCATAGTAAAAATCTTGTTTTTAGCTTTGACTTTTTTGTGGCTGTTTT
TTAAAATTGTAAATTACTAGTAACATGTCATTTCTATAGGATGTTTTAAATTATGTACCTTCCATTGGATAGTTAAAATAATTTCATTTT
ATAAGCCAATTTGAGTGGGAAAGATACAAAGCACACAGTTGTCTCCCCACATTAGGAAGAGTAGTGTGCATTCAGACATTCGGAATTTTT
GCTAGTAGTTGGAGATGTTTCAGTGAGTGAATTAAAACAAAGTCTATTTAACTGACGTGATCTATTTTGTGTCTAAAACAGAGGAATTTA
TCTTGTCCTAGAAGTTCATGAACTATAAGATCTAAGTTTTTTTTTCTTTTTTAACAATAAAATGATTTTTTCTTAAAGTATCAAAGTTGG
AATTGGCTAAAAGTGAAGTAGCATAACTCAGATATGTTGGAACTTGGTACTGAAGCAGGCTTTTTGGTAACAGAAATGACATTTTAAGGG
GTAACTGTATATCCTGTTTTTAGTTCTTTGCCTCTCAGATTCTGTTAACTTAGTTTAAATTCACTGAATACCCTACCACTAAGGCGTTGC
TCATTACAAAAGCATGTTAATTTCAATACAGGAAAACTCTTTTGTAGTTTTATATATGGATTGGGGAAAGTGACTTTGTTTTACTTTTCC
TTTTTATTCCCCTCCATCCTCCAAACTTCCAATCTATATTATTTGTAATGAGAACTTTGGTGGGGGAAAAAAAGCATTAAGAGAATTTTG
GATGTAAAGGCATCTGGTATCTGATGGACCAGCAGGTAGATGTGGTTGGATTGAGAAATTTTGGGTAAGGTAGATGATAGAAGAAAGAGA
TTTTAGGAGACACAGTTCTCTGTGGAACACTTTCTTTCATGTTCCTGTAACTAATTGATCAAGACCCTTTTAAACGCTTATCTTTGTCAG
TTCCGCTTTTGAAAAAACTATTGCCCTAGGATTGTTTCTTCCATATGACAGATGAAGGTTATTGGCTCTGAGTCATTTTTGGCATTATCG
TCACAGATAAAAAGATTGGCAATTAATCTCATAAAAAATCTGAATTATTCCAGATTGCTGCCGATTTTTGCCTAAGAAACAATATGTAAG
TATATTTTATAAACCAAACTTTGTCAACCAATTCTATTGTACGTCTACCCACAGGCAACTTTGAATTTACTTCTCTAGTGCTAAATAAAC
ATTTCAGCGATTTAATCCCCCAACTTGGGGGATGCATTATGAAAAGGTTTTCCTGGAGTCAAGGGGTTTTTCTTTCTCGCTAGTTTTGTG
AAAATTTTTATATCAATAGGCAAATCATTATAACTTTTTAGGGGTTGATGGTTTTTAAGTATATTGGAAATTGTGGTGTCTAAGGATGAT
GTTCAGTGAAGAAAAGGGATCCACTTTTAGAAACCAGCATTGTTTGCTTTCAACTTTCATACTGTATGCTAACTCCTACGTTCCAAAATG
TGCTCATTTGCAGACACAGGTATGCCTATATACATGGAAGTCTCAAATCTGAATTTTTATCCATCTCAATATGACCATTTCTCTCTGTTG
TGAGCTGAACAGATTAAGTATATATCTGCCAGGTTGGGAAATATTTTGGTCTATCTTTTCCTGTCATCAGAACTTAATTTAAAAAAATTA
TCAAAGGTCAGATGTGACTACTACAGTAAGTTGGCTATCATAAAGAATATTCCATAAAATGTTTTATCTGCCATACAAAATTACTGGGTT
TATGGCCGGATGTGGTGGCTCATGCCTGTAATCCCAGCAGTTCAGGATTACAGGTTATATACAGGTTATAACAATGGATACCAGGACATC
AGAATATCTGATAAAGCAAATATTTATATGCTAATTTAAAATATCAAATTGCTACTGGACATAAAATACATCTGGAAGCTTGGGGTAAGA
AGAAAGAAAAGAAGTGTTCCGTTCTGTTTTCAACTAAGGGTAAACGAAGTCCCAGAGTGTTTTCCCTGTAGGTCAAATTAAGGTAACATG
TCTTTATTTGATCATCTATTGTACACCAGATACCTGGCTAAGGGCTTTCCTTTTTTCTCATGTAGTCTTCCAAATGTTCTTTGATAATTG
TCACTATATTATAGATGACAAAGTGAAGACTTACGAGAAATTACTTTGCCCCAAGGTTACAACACTTAGATGGCTGTCCAAGGGCGGGGA
AGAGCCCTGCAAATTCTGTGTCTTGAAGAAAGCAGTGGCCACGCAGTAGTTCCGTGCCCAGGATCTCCCAGAACTAGACTTGGCAACCAC
AGCTGGGCCAGCCTTTTTTGTTAGACCATTCTTCCTGACTCCTGCTTACCATCAGCACCCTTAAAATGACGAAATCAGGCTTAAGTTGCT
TTTAGGTTACACAGACTGGAGTGTAGGCCCTCTCAGGCCAAACATCTTTCCTCTTCTGTGGTGCTAAAATTCTGTATGACCAGACAAGTA
TGGTAATAGGTTTTTTTTTTTTTTTTTTTTGTGCAAATGATTTTGTGTTTAGTAAAATAATGGCTAAACACATGGATCCATTCAAACGCA
CAAATGTGGAAAGTATTGACACGGAAGGAAAGGCTTTGAAGAATTACTGCCTCAGGAAGCAGTGCCATGGATGCGAATTTAACACAGTCT
ACTTCTTCCTAAAGGAATATCATCCCAAGGAATGTCAAAAATTAAAATCACCTTTTAATGTACTGGTTGTTGAGTGTTTCTGCTTTACCT
CAAGTCATTCTGACCACTCTACATCCTGCTTCAAAGTGTTCTGACACTTAGATTTGGAATGGCTCTAATGATTCTTTGTACTTGAATGTG

>6211_6211_3_ARHGEF12-KPNA1_ARHGEF12_chr11_120308091_ENST00000532993_KPNA1_chr3_122156142_ENST00000344337_length(amino acids)=516AA_BP=310
MNRESPTDKKQKVERIASHDFDPTDSSSKKTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGDR
IIKVNGTLVTHSNHLEVVKLIKSGSYVALTVQGRPPGSPQIPLADSEVEPSVIGHMSPIMTSPHSPGASGNMERITSPVLMGEENNVVHN
QKVEILRKMLQKEQERLQLLQEDYNRTPAQRLLKEIQEAKKHIPQLQEQLSKATGSAQDGAVVTPSRPLGDTLTVSEAETDPGDVLGRTD
CSSGDASRPSSDNADSPKSGPKERIYLEENPEKSETIQDTVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIF
PALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALI

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGEF12-KPNA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF12-KPNA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF12-KPNA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGEF12C0043094Weight Gain1CTD_human
TgeneC0036341Schizophrenia1CTD_human