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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:ADNP-MMP24 (FusionGDB2 ID:HG23394TG10893)

Fusion Gene Summary for ADNP-MMP24

check button Fusion gene summary
Fusion gene informationFusion gene name: ADNP-MMP24
Fusion gene ID: hg23394tg10893
HgeneTgene
Gene symbol

ADNP

MMP24

Gene ID

23394

10893

Gene nameactivity dependent neuroprotector homeoboxmatrix metallopeptidase 24
SynonymsADNP1|HVDAS|MRD28MMP-24|MMP25|MT-MMP 5|MT-MMP5|MT5-MMP|MT5MMP|MTMMP5
Cytomap('ADNP')('MMP24')

20q13.13

20q11.22

Type of geneprotein-codingprotein-coding
Descriptionactivity-dependent neuroprotector homeobox proteinADNP homeobox 1activity-dependent neuroprotective proteinactivity-dependent neuroprotectormatrix metalloproteinase-24matrix metallopeptidase 24 (membrane-inserted)matrix metalloproteinase 24 (membrane-inserted)membrane-type 5 matrix metalloproteinasemembrane-type matrix metalloproteinase 5
Modification date2020032220200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000349014, ENST00000371602, 
ENST00000396029, ENST00000396032, 
Fusion gene scores* DoF score17 X 7 X 11=13096 X 7 X 5=210
# samples 226
** MAII scorelog2(22/1309*10)=-2.57288966842058
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/210*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADNP [Title/Abstract] AND MMP24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADNP(49518554)-MMP24(33862075), # samples:2
Anticipated loss of major functional domain due to fusion event.ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ADNP-MMP24 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ADNP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MMP24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A08J-01AADNPchr20

49518554

-MMP24chr20

33859372

+
ChimerDB4BRCATCGA-A8-A08J-01AADNPchr20

49518554

-MMP24chr20

33862075

+


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Fusion Gene ORF analysis for ADNP-MMP24

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000349014ENST00000246186ADNPchr20

49518554

-MMP24chr20

33862075

+
Frame-shiftENST00000371602ENST00000246186ADNPchr20

49518554

-MMP24chr20

33859372

+
Frame-shiftENST00000371602ENST00000246186ADNPchr20

49518554

-MMP24chr20

33862075

+
Frame-shiftENST00000396029ENST00000246186ADNPchr20

49518554

-MMP24chr20

33859372

+
Frame-shiftENST00000396029ENST00000246186ADNPchr20

49518554

-MMP24chr20

33862075

+
Frame-shiftENST00000396032ENST00000246186ADNPchr20

49518554

-MMP24chr20

33859372

+
In-frameENST00000349014ENST00000246186ADNPchr20

49518554

-MMP24chr20

33859372

+
In-frameENST00000396032ENST00000246186ADNPchr20

49518554

-MMP24chr20

33862075

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396032ADNPchr2049518554-ENST00000246186MMP24chr2033862075+3529802361858165
ENST00000349014ADNPchr2049518554-ENST00000246186MMP24chr2033859372+34924981183434249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396032ENST00000246186ADNPchr2049518554-MMP24chr2033862075+0.392322870.6076771
ENST00000349014ENST00000246186ADNPchr2049518554-MMP24chr2033859372+0.0047093910.99529064

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Fusion Genomic Features for ADNP-MMP24


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADNPchr2049518553-MMP24chr2033859371+0.99838470.001615307
ADNPchr2049518553-MMP24chr2033862074+0.0011059670.99889404
ADNPchr2049518553-MMP24chr2033859371+0.99838470.001615307
ADNPchr2049518553-MMP24chr2033862074+0.0011059670.99889404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADNP-MMP24


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:49518554/chr20:33862075)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669643_645444646.0MotifNote=PDZ-binding
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679643_645533646.0MotifNote=PDZ-binding
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669473_521444646.0RepeatNote=Hemopexin 3
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669522_569444646.0RepeatNote=Hemopexin 4
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669624_645444646.0Topological domainCytoplasmic
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679624_645533646.0Topological domainCytoplasmic
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669603_623444646.0TransmembraneHelical
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679603_623533646.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34754_814671103.0DNA bindingHomeobox
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34354_361671103.0RegionNeuroprotective peptide (NAP)
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000349014-3474_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-23662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000371602-2374_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-45662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396029-4574_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33859372ENST00000396032-3474_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000349014-3474_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-23662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000371602-2374_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-45662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396029-4574_97671103.0Zinc fingerC2H2-type 1
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34107_129671103.0Zinc fingerC2H2-type 2%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34165_188671103.0Zinc fingerC2H2-type 3
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34221_244671103.0Zinc fingerC2H2-type 4
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34447_469671103.0Zinc fingerC2H2-type 5%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34489_510671103.0Zinc fingerC2H2-type 6%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34512_535671103.0Zinc fingerC2H2-type 7
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34622_647671103.0Zinc fingerC2H2-type 8%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-34662_686671103.0Zinc fingerC2H2-type 9%3B atypical
HgeneADNPchr20:49518554chr20:33862075ENST00000396032-3474_97671103.0Zinc fingerC2H2-type 1
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669149_152444646.0Compositional biasNote=Poly-Arg
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679149_152533646.0Compositional biasNote=Poly-Arg
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669137_144444646.0MotifCysteine switch
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679137_144533646.0MotifCysteine switch
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669377_425444646.0RepeatNote=Hemopexin 1
TgeneMMP24chr20:49518554chr20:33859372ENST0000024618669426_471444646.0RepeatNote=Hemopexin 2
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679377_425533646.0RepeatNote=Hemopexin 1
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679426_471533646.0RepeatNote=Hemopexin 2
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679473_521533646.0RepeatNote=Hemopexin 3
TgeneMMP24chr20:49518554chr20:33862075ENST0000024618679522_569533646.0RepeatNote=Hemopexin 4
TgeneMMP24chr20:49518554chr20:33859372ENST000002461866953_602444646.0Topological domainExtracellular
TgeneMMP24chr20:49518554chr20:33862075ENST000002461867953_602533646.0Topological domainExtracellular


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Fusion Gene Sequence for ADNP-MMP24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2502_2502_1_ADNP-MMP24_ADNP_chr20_49518554_ENST00000349014_MMP24_chr20_33859372_ENST00000246186_length(transcript)=3492nt_BP=498nt
AATATTCTTAACTAGTCAAACTGAGTCATGTGTACTCTGCTCTGCTGGAAAAGTGACTTTCTGTCTTCCATCAATCGTGGCAGAGGCGTT
TCCAAGAGGAGGCTGGGCAGGCAAAAACAGGTGTCTAAACCCTACTGATTGAGGGCTGGCTATGTGTATTCTAAGCTGGAAGAAATGGAC
TGTTGAAGGGGAAGAAGAACCATGTCTTACTCATCTCTCTATTCCTAGCACAGTTGAGTGGCTAAGTGCAAGTGCTCTGAAAATGATTGT
CTAACAGATGAACAATATATAGAAACTATGTTCCAACTTCCTGTCAACAATCTTGGCAGTTTAAGAAAAGCCCGGAAAACTGTGAAAAAA
ATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACAATTTGAACCTAATGACTTTTATTTGAAAAACACT
ACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGGTGACAAGTATTGGGTGTTTAAGGAGGTGACGGTGGAGCCTG
GGTACCCCCACAGCCTGGGGGAGCTGGGCAGCTGTTTGCCCCGTGAAGGCATTGACACAGCTCTGCGCTGGGAACCTGTGGGCAAGACCT
ACTTTTTCAAAGGCGAGCGGTACTGGCGCTACAGCGAGGAGCGGCGGGCCACGGACCCTGGCTACCCTAAGCCCATCACCGTGTGGAAGG
GCATCCCACAGGCTCCCCAAGGAGCCTTCATCAGCAAGGAAGGATATTACACCTATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACA
ACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGCAACATCCTGCGTGACTGGATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGG
AGCGGCGGCTGCCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTGCCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCT
GCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTACACCATCTTCCAGTTCAAGAACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGC
GGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGCCCTCTCTATCCACTTGGTCTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGG
GCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGGCCCTAGGCTGGGGTCGTACAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCG
TGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGTGGGTGTCTGGCACCCAGCTGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTT
AAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGACCATGCCAGGAGGAGCCCCTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACC
ACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCTGTGGGAAGCCAGCACTAGCTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGG
TCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCCCCTACCCCCACCCCACTGTCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGT
GAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGGCAGATCCCTCAGGAAACCTGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGAT
TTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCAGCTGGGTCTGACAAGGACCCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCA
CTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTTTAGGTGAACTAGAGGTGACTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCC
CAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACTCTAGCGCCCAGACACCCCAGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGG
GCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGAGTTTGTGACCGTCCTCCACTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAG
TCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAGTTAGGTGAGGCAGAGATGGCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTT
CGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGCCCCCACTACTCTGAGGCCGACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGC
TGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCTGACCTCGCTCACTGGGCCCATCTTCCCACACTGCTCTTAGAAGGACACCCCTACC
GGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTGACCTTCACTGGCCCGCCCTTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCT
GCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCTTGTCACTGAGGAGCCCTAGACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCT
CTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAGCGTGCTGGCCGGGTCTCGGATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTG
CCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGCTTACCCTGTAGCACAGACAGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAA
ATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCTGTGTCCCCTGTCATCATCCTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCT
GGGACAGGCAGGGAACAACTGCGGAGATATTAGTGATTCATAGGTTTGTACAGTGTTTTATACTTTGCAAAGCACTTTATTAGCTCACAC
CTGTCCACTCACATGAAACTCGTGTTAGGCCCTGGGAGGCCGACGGTAACTCTCACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTAC
TTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTGTGTCCCCATCTGTGGACCCCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTG
TATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTCCTGGTCCCTGTCCACTCCTCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCA
CCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTGGCAGGCCAGCTGAGAATGAACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGG
TGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCCTAGAGGCTTCCAATCTCAGATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACC
CCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGGGGCCCCAGAGCCTAGCTTCCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTC
AGTCACATTTTAAACTGATCAGCCTTTGTATAATGTTTTTTAAATCATTTCTAAATAAAACAGAAATACAGA

>2502_2502_1_ADNP-MMP24_ADNP_chr20_49518554_ENST00000349014_MMP24_chr20_33859372_ENST00000246186_length(amino acids)=249AA_BP=1
MARAAPQTLVRKGLAGQTKWIERALGCSHPFLDWPLIVGDRLRACLVLELEDGVDQHQDAEGQDAGDDHGHGVHGARHIVDGHHDVHVVL
GQPPLLPPLHLLLVAAHPVTQDVARVAWLHAQFLVVKLPVVPALVEIGVISFLADEGSLGSLWDALPHGDGLRVARVRGPPLLAVAPVPL
AFEKVGLAHRFPAQSCVNAFTGQTAAQLPQAVGVPRLHRHLLKHPILVTWFFVSDGSHSPTSSHVVFFK

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>2502_2502_2_ADNP-MMP24_ADNP_chr20_49518554_ENST00000396032_MMP24_chr20_33862075_ENST00000246186_length(transcript)=3529nt_BP=802nt
TTTGGCTAGGGCAGGTTCGGGGACTCGGTCCGAGGCGCTTGTATTGTCTGCTGAGGGGAGACGCGGGATCAGCCCCCTCCCCCGCCCGTT
GCCGCCGCCGCCTCCGCCGGCCCGGTCTCCCCTCCGCCGCCCGCCGGGATCCATGAGCTGAACTCCCGCCCCCCCCCCCCCGGCCGCCGC
CATCTTGTGCCCCCTCCCCCTCCCGCAGGCAGCGCTAAGGGGGATTTTGGCGTCTTCTCAGACACAGCTCCCTCTCTCGGTCCCCGCTGC
TGAGGAGCGAGAGGAGCGCGGCCGCCGCCGCCCGCGCCGGTGAAGCCGCCTCTCCCACACCCTCCGTCTCCTCCCTCCGCCCCTCCTTTG
TCTGCACCGCTCGACGACGCCGCCGCCGCCCGCCGCTCTGCTGCGCCCGCCGCGCCCCCCGGCAGCACCCGCGGCCGCGGCGCGAGCCGG
AGTCCGCCGAGCCGGAGCGCGACGAGGCCCCGGGCGCGCCCTCCCCGCTGCCGCCACCGCCGTGCCGCCGCCATCCGCCCGCCGCCGCCG
CCGCTGTCCGGCCCCCGAGCACGCCGGCCCCGCGCGCGCCTCGAGGCCGAGTCAAGAAACTATGTTCCAACTTCCTGTCAACAATCTTGG
CAGTTTAAGAAAAGCCCGGAAAACTGTGAAAAAAATACTTAGTGACATTGGGTTGGAATACTGTAAAGAACATATAGAAGATTTTAAACA
ATTTGAACCTAATGACTTTTATTTGAAAAACACTACATGGGAGGATGTAGGACTGTGGGACCCATCACTTACGAAAAACCAGATTACACC
TATTTCTACAAGGGCCGGGACTACTGGAAGTTTGACAACCAGAAACTGAGCGTGGAGCCAGGCTACCCGCGCAACATCCTGCGTGACTGG
ATGGGCTGCAACCAGAAGGAGGTGGAGCGGCGGAAGGAGCGGCGGCTGCCCCAGGACGACGTGGACATCATGGTGACCATCAACGATGTG
CCGGGCTCCGTGAACGCCGTGGCCGTGGTCATCCCCTGCATCCTGTCCCTCTGCATCCTGGTGCTGGTCTACACCATCTTCCAGTTCAAG
AACAAGACAGGCCCTCAGCCTGTCACCTACTATAAGCGGCCAGTCCAGGAATGGGTGTGAGCAGCCCAGAGCCCTCTCTATCCACTTGGT
CTGGCCAGCCAGGCCCTTCCTCACCAGGGTCTGAGGGGCAGCTCTGGCCAGTGCTCACCAGGGCCAGCAGGGCCCTAGGCTGGGGTCGTA
CAGCTGAAGTGGTGGGTGCATTGGCCTAGGCTGAGCGTGGGGCAGGGAATTATGGGGGCTGTGCCCCAGGGTGGGTGTCTGGCACCCAGC
TGCCAGCCTTCTGTCCTGGGCAAACTACTCCCTACTTAAGGGAATAGGCCAGGCTCCATCCGGAGGCAGGGACCATGCCAGGAGGAGCCC
CTGTGGTCACGGCATCCTGTGGTGTCCATGAGGTACCACAGCTCCACTCCTGGCTGGAACCCAGCACCCTCTGTGGGAAGCCAGCACTAG
CTCTCATCCCCCATCCGGGAGATACCACCAGTCCTGGTCCCCTTTTGCCAACACCTGCTGGTCAGATGTCCCCCTACCCCCACCCCACTG
TCCTCCAAGGCTACAGGACCCCTGCTTCTGACACAGTGAGCAACAAGCCTGGGTTTCCCTGCTGGCAGACGGCAGATCCCTCAGGAAACC
TGCTCCACTTGTCAGGGTCTCTTCGGAGACCCAGGATTTAGGGTCACATGCTGCAGGCAGGGCTGTGGCCCAGCTGGGTCTGACAAGGAC
CCAGCTGTCACATCGTGAATATTTAAATGTCCTGTCACTACTGTCCCATTTTGCAAAGGCTGCTTGAGGCTTTAGGTGAACTAGAGGTGA
CTGTCTTGGTGATGAGGCCAGCATAGCGGCCCTCCCCCAGGCGACAAGGACCAAGGTGCTGCTAAGGCCACTCTAGCGCCCAGACACCCC
AGTAGCTGAGCTCTGCTCCTATGGCTACAGAGCTGGGGCAGAAGCTGACCCCATTTCTGGAGGAAGATCCGAGTTTGTGACCGTCCTCCA
CTCCCCTCTATTGTCACTGTCCCCAGCTTTGCTCCAGTCTGTCACTTGCAGCCTGGAGCTCAGCCTCACCAGTTAGGTGAGGCAGAGATG
GCTGCAGGGCCAACACTGGCAGAGCCTGGGAGTCCTTCGGAAGGGGACCAGGGCGTCTGAAGTGCTCAGTGCCCCCACTACTCTGAGGCC
GACTCCAGCTACTCTGAGGCCGACTCAATCTCTCGGCTGGAAGCAGTGTTTTCCCAGAGCTTGGCCCTTGCTGACCTCGCTCACTGGGCC
CATCTTCCCACACTGCTCTTAGAAGGACACCCCTACCGGTAGCAGCCCCAAGCTGAGGGGGCTCCCTTTTTGACCTTCACTGGCCCGCCC
TTCACTGTCTCCAGCAGGAGTTCCTAGGGCTTGGCCTGCCTTGCTCCACAGTACGGCGGAGGCAGCCCTGCTTGTCACTGAGGAGCCCTA
GACAAGGCCAATGGGTTCATCAATGCCCACTGGCTCTCTGCCAAAGCCAAAAAGGTGTCAGGCAGTCTCCAGCGTGCTGGCCGGGTCTCG
GATGCCACCCCTGCTCACTGAGCCTGCATGGGCCTTGCCCCCGACCCTGTGGTCTCTGGGATTGGGGTCGGCTTACCCTGTAGCACAGAC
AGGGACTCCTGCTGCCCTGGGAGCTGTCTCAAGCAAAATCTCTTGTCCCAGAGGTGCCCATGTGGGTCCGCTGTGTCCCCTGTCATCATC
CTTGTTTTTTCTCATTTTGGCCAAGGGCAGGCTCCCTGGGACAGGCAGGGAACAACTGCGGAGATATTAGTGATTCATAGGTTTGTACAG
TGTTTTATACTTTGCAAAGCACTTTATTAGCTCACACCTGTCCACTCACATGAAACTCGTGTTAGGCCCTGGGAGGCCGACGGTAACTCT
CACCGTGCCCTCAGATGAAGCACAGAGAGGTTGTTACTTGCCCGGGCCATCCAGTGGGCTGGCTGGGTCTTGTGTCCCCATCTGTGGACC
CCTCTAGGGTCTGAGATGAGATGAGAAGTGTCTCCTGTATCCACCTCTTCCTGGCCTCCCTTCCCCCACTTCCTGGTCCCTGTCCACTCC
TCAGGTTGGTGCTCTCACTTCTTGAAAGCTCTAGGCACCCCCGCCTCCCGCCAGGCTCCCCATTGGCTCCTGGCAGGCCAGCTGAGAATG
AACAGGAGATGGAGGCAGGCAGCCCAGGCTGCAGAGGTGAGGGATGTGGGGCCAGGCCCAGAGGGCTCAGCCTAGAGGCTTCCAATCTCA
GATTCTCCTGCCTGTGGTCATCTGTTTGTCCATCACCCCAGGACAGGGCAGACAGAGGGGCAAAGCACTGGGGGCCCCAGAGCCTAGCTT
CCCCTCAGCCTGGGGGACATCACAGCATTTCAGTGTCAGTCACATTTTAAACTGATCAGCCTTTGTATAATGTTTTTTAAATCATTTCTA
AATAAAACAGAAATACAGA

>2502_2502_2_ADNP-MMP24_ADNP_chr20_49518554_ENST00000396032_MMP24_chr20_33862075_ENST00000246186_length(amino acids)=165AA_BP=16
MHRSTTPPPPAALLRPPRPPAAPAAAARAGVRRAGARRGPGRALPAAATAVPPPSARRRRRCPAPEHAGPARASRPSQETMFQLPVNNLG
SLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQITPISTRAGTTGSLTTRN

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Fusion Gene PPI Analysis for ADNP-MMP24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADNP-MMP24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADNP-MMP24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADNPC4014538ADNP-related multiple congenital anomalies, intellectual disability, autism spectrum disorder2CTD_human;GENOMICS_ENGLAND;ORPHANET
HgeneADNPC0004352Autistic Disorder1CTD_human
HgeneADNPC0015923Fetal Alcohol Syndrome1PSYGENET
HgeneADNPC0036341Schizophrenia1PSYGENET
HgeneADNPC1535926Neurodevelopmental Disorders1CTD_human
HgeneADNPC1542327Fetus or newborn affected by alcohol transmitted via placenta or breast milk1PSYGENET
TgeneC0027627Neoplasm Metastasis1CTD_human