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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SF3B3-ADAM12 (FusionGDB2 ID:HG23450TG8038) |
Fusion Gene Summary for SF3B3-ADAM12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SF3B3-ADAM12 | Fusion gene ID: hg23450tg8038 | Hgene | Tgene | Gene symbol | SF3B3 | ADAM12 | Gene ID | 23450 | 8038 |
| Gene name | splicing factor 3b subunit 3 | ADAM metallopeptidase domain 12 | |
| Synonyms | RSE1|SAP130|SF3b130|STAF130 | ADAM12-OT1|CAR10|MCMP|MCMPMltna|MLTN|MLTNA | |
| Cytomap | ('SF3B3')('ADAM12') 16q22.1 | 10q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130 | disintegrin and metalloproteinase domain-containing protein 12meltrin-alphametalloprotease-disintegrin 12 transmembrane | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000302516, | ||
| Fusion gene scores | * DoF score | 13 X 15 X 9=1755 | 14 X 15 X 4=840 |
| # samples | 18 | 17 | |
| ** MAII score | log2(18/1755*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(17/840*10)=-2.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SF3B3 [Title/Abstract] AND ADAM12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SF3B3(70604052)-ADAM12(127967557), # samples:4 | ||
| Anticipated loss of major functional domain due to fusion event. | SF3B3-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SF3B3-ADAM12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SF3B3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166|29360106 |
| Hgene | SF3B3 | GO:0042177 | negative regulation of protein catabolic process | 23951410 |
| Fusion gene breakpoints across SF3B3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ADAM12 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | TGCT | TCGA-2G-AAFI-01A | SF3B3 | chr16 | 70604052 | - | ADAM12 | chr10 | 127967557 | - |
| ChimerDB4 | TGCT | TCGA-2G-AAFI-01A | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - |
| ChimerDB4 | TGCT | TCGA-2G-AAFI | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - |
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Fusion Gene ORF analysis for SF3B3-ADAM12 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000302516 | ENST00000467145 | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - |
| In-frame | ENST00000302516 | ENST00000368676 | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - |
| In-frame | ENST00000302516 | ENST00000368679 | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000302516 | SF3B3 | chr16 | 70604052 | + | ENST00000368679 | ADAM12 | chr10 | 127967557 | - | 11061 | 3619 | 109 | 6162 | 2017 |
| ENST00000302516 | SF3B3 | chr16 | 70604052 | + | ENST00000368676 | ADAM12 | chr10 | 127967557 | - | 6436 | 3619 | 109 | 5649 | 1846 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000302516 | ENST00000368679 | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - | 0.000372886 | 0.9996271 |
| ENST00000302516 | ENST00000368676 | SF3B3 | chr16 | 70604052 | + | ADAM12 | chr10 | 127967557 | - | 0.000715553 | 0.99928445 |
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Fusion Genomic Features for SF3B3-ADAM12 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for SF3B3-ADAM12 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70604052/chr10:127967557) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 514_649 | 62 | 739.0 | Compositional bias | Note=Cys-rich | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 514_649 | 62 | 910.0 | Compositional bias | Note=Cys-rich | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 214_416 | 62 | 739.0 | Domain | Peptidase M12B | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 424_510 | 62 | 739.0 | Domain | Disintegrin | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 656_688 | 62 | 739.0 | Domain | EGF-like | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 214_416 | 62 | 910.0 | Domain | Peptidase M12B | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 424_510 | 62 | 910.0 | Domain | Disintegrin | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 656_688 | 62 | 910.0 | Domain | EGF-like | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 177_184 | 62 | 739.0 | Motif | Cysteine switch | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 828_834 | 62 | 739.0 | Motif | SH3-binding%3B class II | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 834_841 | 62 | 739.0 | Motif | SH3-binding%3B class I | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 885_891 | 62 | 739.0 | Motif | SH3-binding%3B class I | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 177_184 | 62 | 910.0 | Motif | Cysteine switch | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 828_834 | 62 | 910.0 | Motif | SH3-binding%3B class II | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 834_841 | 62 | 910.0 | Motif | SH3-binding%3B class I | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 885_891 | 62 | 910.0 | Motif | SH3-binding%3B class I | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 208_708 | 62 | 739.0 | Topological domain | Extracellular | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 730_909 | 62 | 739.0 | Topological domain | Cytoplasmic | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 208_708 | 62 | 910.0 | Topological domain | Extracellular | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 730_909 | 62 | 910.0 | Topological domain | Cytoplasmic | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368676 | 1 | 19 | 709_729 | 62 | 739.0 | Transmembrane | Helical | |
| Tgene | ADAM12 | chr16:70604052 | chr10:127967557 | ENST00000368679 | 1 | 23 | 709_729 | 62 | 910.0 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for SF3B3-ADAM12 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >81064_81064_1_SF3B3-ADAM12_SF3B3_chr16_70604052_ENST00000302516_ADAM12_chr10_127967557_ENST00000368676_length(transcript)=6436nt_BP=3619nt GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA TGGACTTGAGGTGTCAGAAATGGCTGTTTCTGAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTT TGATGCCTACATCATTGTGTCTTTCGTGAATGCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCT GGGGACCACCCCGACCTTGTCCTGCTCCTTATTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGA CAAGAGAGTCAATGAGTGGAAGACCCCTGGAAAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGG AGGAGAGCTGGTCTATTTCGAGATGGATCCTTCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCAT GAGTCTGGCCAATGTACCCCCTGGAGAGCAGCGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGA TCCCTCAGACTGTTTGCAACCTCTAAGCATGCAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAA GCAGGATGAGCTGGGTGAGAGGGGCTCGATTGGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGA CCCTGTCACTGGGGATTTGTCTGATACTCGCACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGA GGCAGTATTGGCCATGTCAAGCCGCTCATGGTTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGA ATTTGCATCGGGTTTTGCCTCGGAACAGTGTCCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCT CGGTGCTGTCTTCAATCAAGTAGCCTTCCCACTGCAGTACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCAT TGAAACGGACCACAATGCCTACACTGAGGCCACGAAAGCTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGA TGAGCGGGAGCTGGCCGCAGAGATGGCAGCAGCATTCCTCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGG GCAGTGGGCCTCTGTGATCCGAGTGATGAATCCCATTCAAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAG TGTGGCTGTGTGCAGGTTTTCCAACACTGGTGAAGACTGGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGT GGCAGGGGGCTTCGTCTATACTTACAAGCTTGTGAACAATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGC TGCTATTGCCCCATTCCAGGGGAGGGTGTTGATTGGTGTGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAA ATGTGAGAATAAGCATATTGCCAATTATATCTCTGGGATCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCAT CTGGGTTCGCTACAAGCGTAATGAAAACCAGCTTATCATCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGA CTATGACACTGTGGCTGGGGCAGACAAGTTTGGCAACATATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCC TACAGGAAACAAAGCCCTGTGGGACCGTGGCTTGCTCAATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGAC GGTGCTGTCCTTGCAGAAGACCACGCTGATCCCTGGAGGCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGT GCCATTCACGTCCCATGAGAATCATCCAGAAGTGCTGAATATTCGACTACAACGGGAAAGCAAAGAACTGATCATAAATCTGGAAAGAAA TGAAGGTCTCATTGCCAGCAGTTTCACGGAAACCCACTATCTGCAAGACGGTACTGATGTCTCCCTCGCTCGAAATTACACGGTAATTCT GGGTCACTGTTACTACCATGGACATGTACGGGGATATTCTGATTCAGCAGTCAGTCTCAGCACGTGTTCTGGTCTCAGGGGACTTATTGT GTTTGAAAATGAAAGCTATGTCTTAGAACCAATGAAAAGTGCAACCAACAGATACAAACTCTTCCCAGCGAAGAAGCTGAAAAGCGTCCG GGGATCATGTGGATCACATCACAACACACCAAACCTCGCTGCAAAGAATGTGTTTCCACCACCCTCTCAGACATGGGCAAGAAGGCATAA AAGAGAGACCCTCAAGGCAACTAAGTATGTGGAGCTGGTGATCGTGGCAGACAACCGAGAGTTTCAGAGGCAAGGAAAAGATCTGGAAAA AGTTAAGCAGCGATTAATAGAGATTGCTAATCACGTTGACAAGTTTTACAGACCACTGAACATTCGGATCGTGTTGGTAGGCGTGGAAGT GTGGAATGACATGGACAAATGCTCTGTAAGTCAGGACCCATTCACCAGCCTCCATGAATTTCTGGACTGGAGGAAGATGAAGCTTCTACC TCGCAAATCCCATGACAATGCGCAGCTTGTCAGTGGGGTTTATTTCCAAGGGACCACCATCGGCATGGCCCCAATCATGAGCATGTGCAC GGCAGACCAGTCTGGGGGAATTGTCATGGACCATTCAGACAATCCCCTTGGTGCAGCCGTGACCCTGGCACATGAGCTGGGCCACAATTT CGGGATGAATCATGACACACTGGACAGGGGCTGTAGCTGTCAAATGGCGGTTGAGAAAGGAGGCTGCATCATGAACGCTTCCACCGGGTA CCCATTTCCCATGGTGTTCAGCAGTTGCAGCAGGAAGGACTTGGAGACCAGCCTGGAGAAAGGAATGGGGGTGTGCCTGTTTAACCTGCC GGAAGTCAGGGAGTCTTTCGGGGGCCAGAAGTGTGGGAACAGATTTGTGGAAGAAGGAGAGGAGTGTGACTGTGGGGAGCCAGAGGAATG TATGAATCGCTGCTGCAATGCCACCACCTGTACCCTGAAGCCGGACGCTGTGTGCGCACATGGGCTGTGCTGTGAAGACTGCCAGCTGAA GCCTGCAGGAACAGCGTGCAGGGACTCCAGCAACTCCTGTGACCTCCCAGAGTTCTGCACAGGGGCCAGCCCTCACTGCCCAGCCAACGT GTACCTGCACGATGGGCACTCATGTCAGGATGTGGACGGCTACTGCTACAATGGCATCTGCCAGACTCACGAGCAGCAGTGTGTCACGCT CTGGGGACCAGGTGCTAAACCTGCCCCTGGGATCTGCTTTGAGAGAGTCAATTCTGCAGGTGATCCTTATGGCAACTGTGGCAAAGTCTC GAAGAGTTCCTTTGCCAAATGCGAGATGAGAGATGCTAAATGTGGAAAAATCCAGTGTCAAGGAGGTGCCAGCCGGCCAGTCATTGGTAC CAATGCCGTTTCCATAGAAACAAACATCCCCCTGCAGCAAGGAGGCCGGATTCTGTGCCGGGGGACCCACGTGTACTTGGGCGATGACAT GCCGGACCCAGGGCTTGTGCTTGCAGGCACAAAGTGTGCAGATGGAAAAATCTGCCTGAATCGTCAATGTCAAAATATTAGTGTCTTTGG GGTTCACGAGTGTGCAATGCAGTGCCACGGCAGAGGGGTGTGCAACAACAGGAAGAACTGCCACTGCGAGGCCCACTGGGCACCTCCCTT CTGTGACAAGTTTGGCTTTGGAGGAAGCACAGACAGCGGCCCCATCCGGCAAGCAGAAGCAAGGCAGGAAGCTGCAGAGTCCAACAGGGA GCGCGGCCAGGGCCAGGAGCCCGTGGGATCGCAGGAGCATGCGTCTACTGCCTCACTGACACTCATCTGAGCCCTCCCATGACATGGAGA CCGTGACCAGTGCTGCTGCAGAGGAGGTCACGCGTCCCCAAGGCCTCCTGTGACTGGCAGCATTGACTCTGTGGCTTTGCCATCGTTTCC ATGACAACAGACACAACACAGTTCTCGGGGCTCAGGAGGGGAAGTCCAGCCTACCAGGCACGTCTGCAGAAACAGTGCAAGGAAGGGCAG CGACTTCCTGGTTGAGCTTCTGCTAAAACATGGACATGCTTCAGTGCTGCTCCTGAGAGAGTAGCAGGTTACCACTCTGGCAGGCCCCAG CCCTGCAGCAAGGAGGAAGAGGACTCAAAAGTCTGGCCTTTCACTGAGCCTCCACAGCAGTGGGGGAGAAGCAAGGGTTGGGCCCAGTGT CCCCTTTCCCCAGTGACACCTCAGCCTTGGCAGCCCTGATGACTGGTCTCTGGCTGCAACTTAATGCTCTGATATGGCTTTTAGCATTTA TTATATGAAAATAGCAGGGTTTTAGTTTTTAATTTATCAGAGACCCTGCCACCCATTCCATCTCCATCCAAGCAAACTGAATGGCAATGA AACAAACTGGAGAAGAAGGTAGGAGAAAGGGCGGTGAACTCTGGCTCTTTGCTGTGGACATGCGTGACCAGCAGTACTCAGGTTTGAGGG TTTGCAGAAAGCCAGGGAACCCACAGAGTCACCAACCCTTCATTTAACAAGTAAGAATGTTAAAAAGTGAAAACAATGTAAGAGCCTAAC >81064_81064_1_SF3B3-ADAM12_SF3B3_chr16_70604052_ENST00000302516_ADAM12_chr10_127967557_ENST00000368676_length(amino acids)=1846AA_BP=1170 MDIHTILLAAGFLGLRTVGVTKAWRSGWLRFPAAMFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTV EVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNR DAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLI TVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIR LKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLA NEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTL SCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVP PGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDL SDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQ VAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVI RVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQ GRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAG ADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHE NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESY VLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLI EIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESF GGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGH SCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIE TNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGF -------------------------------------------------------------- >81064_81064_2_SF3B3-ADAM12_SF3B3_chr16_70604052_ENST00000302516_ADAM12_chr10_127967557_ENST00000368679_length(transcript)=11061nt_BP=3619nt GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA TGGACTTGAGGTGTCAGAAATGGCTGTTTCTGAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTT TGATGCCTACATCATTGTGTCTTTCGTGAATGCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCT GGGGACCACCCCGACCTTGTCCTGCTCCTTATTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGA CAAGAGAGTCAATGAGTGGAAGACCCCTGGAAAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGG AGGAGAGCTGGTCTATTTCGAGATGGATCCTTCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCAT GAGTCTGGCCAATGTACCCCCTGGAGAGCAGCGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGA TCCCTCAGACTGTTTGCAACCTCTAAGCATGCAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAA GCAGGATGAGCTGGGTGAGAGGGGCTCGATTGGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGA CCCTGTCACTGGGGATTTGTCTGATACTCGCACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGA GGCAGTATTGGCCATGTCAAGCCGCTCATGGTTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGA ATTTGCATCGGGTTTTGCCTCGGAACAGTGTCCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGGATTTTGGCATTAGAGAAGCT CGGTGCTGTCTTCAATCAAGTAGCCTTCCCACTGCAGTACACACCCAGGAAATTTGTCATCCACCCTGAGAGTAACAACCTTATTATCAT TGAAACGGACCACAATGCCTACACTGAGGCCACGAAAGCTCAGAGAAAGCAGCAGATGGCAGAGGAAATGGTGGAAGCAGCAGGGGAGGA TGAGCGGGAGCTGGCCGCAGAGATGGCAGCAGCATTCCTCAATGAAAACCTCCCTGAATCCATCTTTGGAGCTCCCAAGGCTGGCAATGG GCAGTGGGCCTCTGTGATCCGAGTGATGAATCCCATTCAAGGGAACACACTGGACCTTGTCCAGCTGGAACAGAATGAGGCAGCTTTTAG TGTGGCTGTGTGCAGGTTTTCCAACACTGGTGAAGACTGGTATGTGCTGGTGGGTGTGGCCAAGGACCTGATACTAAACCCCCGATCTGT GGCAGGGGGCTTCGTCTATACTTACAAGCTTGTGAACAATGGGGAAAAACTGGAGTTTTTGCACAAGACTCCTGTGGAAGAGGTCCCTGC TGCTATTGCCCCATTCCAGGGGAGGGTGTTGATTGGTGTGGGGAAGCTGTTGCGTGTCTATGACCTGGGAAAGAAGAAGTTACTCCGAAA ATGTGAGAATAAGCATATTGCCAATTATATCTCTGGGATCCAGACTATCGGACATAGGGTAATTGTATCTGATGTCCAAGAAAGTTTCAT CTGGGTTCGCTACAAGCGTAATGAAAACCAGCTTATCATCTTTGCTGATGATACCTACCCCCGATGGGTCACTACAGCCAGCCTCCTGGA CTATGACACTGTGGCTGGGGCAGACAAGTTTGGCAACATATGTGTGGTGAGGCTCCCACCTAACACCAATGATGAAGTAGATGAGGATCC TACAGGAAACAAAGCCCTGTGGGACCGTGGCTTGCTCAATGGGGCCTCCCAGAAGGCAGAGGTGATCATGAACTACCATGTCGGGGAGAC GGTGCTGTCCTTGCAGAAGACCACGCTGATCCCTGGAGGCTCAGAATCACTTGTCTATACCACCTTGTCTGGAGGAATTGGCATCCTTGT GCCATTCACGTCCCATGAGAATCATCCAGAAGTGCTGAATATTCGACTACAACGGGAAAGCAAAGAACTGATCATAAATCTGGAAAGAAA TGAAGGTCTCATTGCCAGCAGTTTCACGGAAACCCACTATCTGCAAGACGGTACTGATGTCTCCCTCGCTCGAAATTACACGGTAATTCT GGGTCACTGTTACTACCATGGACATGTACGGGGATATTCTGATTCAGCAGTCAGTCTCAGCACGTGTTCTGGTCTCAGGGGACTTATTGT GTTTGAAAATGAAAGCTATGTCTTAGAACCAATGAAAAGTGCAACCAACAGATACAAACTCTTCCCAGCGAAGAAGCTGAAAAGCGTCCG GGGATCATGTGGATCACATCACAACACACCAAACCTCGCTGCAAAGAATGTGTTTCCACCACCCTCTCAGACATGGGCAAGAAGGCATAA AAGAGAGACCCTCAAGGCAACTAAGTATGTGGAGCTGGTGATCGTGGCAGACAACCGAGAGTTTCAGAGGCAAGGAAAAGATCTGGAAAA AGTTAAGCAGCGATTAATAGAGATTGCTAATCACGTTGACAAGTTTTACAGACCACTGAACATTCGGATCGTGTTGGTAGGCGTGGAAGT GTGGAATGACATGGACAAATGCTCTGTAAGTCAGGACCCATTCACCAGCCTCCATGAATTTCTGGACTGGAGGAAGATGAAGCTTCTACC TCGCAAATCCCATGACAATGCGCAGCTTGTCAGTGGGGTTTATTTCCAAGGGACCACCATCGGCATGGCCCCAATCATGAGCATGTGCAC GGCAGACCAGTCTGGGGGAATTGTCATGGACCATTCAGACAATCCCCTTGGTGCAGCCGTGACCCTGGCACATGAGCTGGGCCACAATTT CGGGATGAATCATGACACACTGGACAGGGGCTGTAGCTGTCAAATGGCGGTTGAGAAAGGAGGCTGCATCATGAACGCTTCCACCGGGTA CCCATTTCCCATGGTGTTCAGCAGTTGCAGCAGGAAGGACTTGGAGACCAGCCTGGAGAAAGGAATGGGGGTGTGCCTGTTTAACCTGCC GGAAGTCAGGGAGTCTTTCGGGGGCCAGAAGTGTGGGAACAGATTTGTGGAAGAAGGAGAGGAGTGTGACTGTGGGGAGCCAGAGGAATG TATGAATCGCTGCTGCAATGCCACCACCTGTACCCTGAAGCCGGACGCTGTGTGCGCACATGGGCTGTGCTGTGAAGACTGCCAGCTGAA GCCTGCAGGAACAGCGTGCAGGGACTCCAGCAACTCCTGTGACCTCCCAGAGTTCTGCACAGGGGCCAGCCCTCACTGCCCAGCCAACGT GTACCTGCACGATGGGCACTCATGTCAGGATGTGGACGGCTACTGCTACAATGGCATCTGCCAGACTCACGAGCAGCAGTGTGTCACGCT CTGGGGACCAGGTGCTAAACCTGCCCCTGGGATCTGCTTTGAGAGAGTCAATTCTGCAGGTGATCCTTATGGCAACTGTGGCAAAGTCTC GAAGAGTTCCTTTGCCAAATGCGAGATGAGAGATGCTAAATGTGGAAAAATCCAGTGTCAAGGAGGTGCCAGCCGGCCAGTCATTGGTAC CAATGCCGTTTCCATAGAAACAAACATCCCCCTGCAGCAAGGAGGCCGGATTCTGTGCCGGGGGACCCACGTGTACTTGGGCGATGACAT GCCGGACCCAGGGCTTGTGCTTGCAGGCACAAAGTGTGCAGATGGAAAAATCTGCCTGAATCGTCAATGTCAAAATATTAGTGTCTTTGG GGTTCACGAGTGTGCAATGCAGTGCCACGGCAGAGGGGTGTGCAACAACAGGAAGAACTGCCACTGCGAGGCCCACTGGGCACCTCCCTT CTGTGACAAGTTTGGCTTTGGAGGAAGCACAGACAGCGGCCCCATCCGGCAAGCAGATAACCAAGGTTTAACCATAGGAATTCTGGTGAC CATCCTGTGTCTTCTTGCTGCCGGATTTGTGGTTTATCTCAAAAGGAAGACCTTGATACGACTGCTGTTTACAAATAAGAAGACCACCAT TGAAAAACTAAGGTGTGTGCGCCCTTCCCGGCCACCCCGTGGCTTCCAACCCTGTCAGGCTCACCTCGGCCACCTTGGAAAAGGCCTGAT GAGGAAGCCGCCAGATTCCTACCCACCGAAGGACAATCCCAGGAGATTGCTGCAGTGTCAGAATGTTGACATCAGCAGACCCCTCAACGG CCTGAATGTCCCTCAGCCCCAGTCAACTCAGCGAGTGCTTCCTCCCCTCCACCGGGCTCCACGTGCACCTAGCGTCCCTGCCAGACCCCT GCCAGCCAAGCCTGCACTTAGGCAGGCCCAGGGGACCTGTAAGCCAAACCCCCCTCAGAAGCCTCTGCCTGCAGATCCTCTGGCCAGAAC AACTCGGCTCACTCATGCCTTGGCCAGGACCCCAGGACAATGGGAGACTGGGCTCCGCCTGGCACCCCTCAGACCTGCTCCACAATATCC ACACCAAGTGCCCAGATCCACCCACACCGCCTATATTAAGTGAGAAGCCGACACCTTTTTTCAACAGTGAAGACAGAAGTTTGCACTATC TTTCAGCTCCAGTTGGAGTTTTTTGTACCAACTTTTAGGATTTTTTTTAATGTTTAAAACATCATTACTATAAGAACTTTGAGCTACTGC CGTCAGTGCTGTGCTGTGCTATGGTGCTCTGTCTACTTGCTCAGGTACTTGTAAATTATTAATTTATGCAGAATGTTGATTACAGTGCAG TGCGCTGTAGTAGGCATTTTTACCATCACTGAGTTTTCCATGGCAGGAAGGCTTGTTGTGCTTTTAGTATTTTAGTGAACTTGAAATATC CTGCTTGATGGGATTCTGGACAGGATGTGTTTGCTTTCTGATCAAGGCCTTATTGGAAAGCAGTCCCCCAACTACCCCCAGCTGTGCTTA TGGTACCAGATGCAGCTCAAGAGATCCCAAGTAGAATCTCAGTTGATTTTCTGGATTCCCCATCTCAGGCCAGAGCCAAGGGGCTTCAGG TCCAGGCTGTGTTTGGCTTTCAGGGAGGCCCTGTGCCCCTTGACAACTGGCAGGCAGGCTCCCAGGGACACCTGGGAGAAATCTGGCTTC TGGCCAGGAAGCTTTGGTGAGAACCTGGGTTGCAGACAGGAATCTTAAGGTGTAGCCACACCAGGATAGAGACTGGAACACTAGACAAGC CAGAACTTGACCCTGAGCTGACCAGCCGTGAGCATGTTTGGAAGGGGTCTGTAGTGTCACTCAAGGCGGTGCTTGATAGAAATGCCAAGC ACTTCTTTTTCTCGCTGTCCTTTCTAGAGCACTGCCACCAGTAGGTTATTTAGCTTGGGAAAGGTGGTGTTTCTGTAAGAAACCTACTGC CCAGGCACTGCAAACCGCCACCTCCCTATACTGCTTGGAGCTGAGCAAATCACCACAAACTGTAATACAATGATCCTGTATTCAGACAGA TGAGGCTTTCCATGGGACCACAACTATTTTCAGATGTGAACCATTAACCAGATCTAGTCAATCAAGTCTGTTTACTGCAAGGTTCAACTT ATTAACAATTAGGCAGACTCTTTATGCTTGCAAAAACTACAACCAATGGAATGTGATGTTCATGGGTATAGTTCATGTCTGCTATCATTA TTCGTAGATATTGGACAAAGAACCTTCTCTATGGGGCATCCTCTTTTTCCAACTTGGCTGCAGGAATCTTTAAAAGATGCTTTTAACAGA GTCTGAACCTATTTCTTAAACACTTGCAACCTACCTGTTGAGCATCACAGAATGTGATAAGGAAATCAACTTGCTTATCAACTTCCTAAA TATTATGAGATGCTGGCTTGGGCAGCATCCCCTTGAACTCTTCACTCTTCAAATGCCTGACTAGGGAGCCATGTTTCACAAGGTCTTTAA AGTGACTAATGGCATGAGAAATACAAAAATACTCAGATAAGGTAAAATGCCATGATGCCTCTGTCTTCTGGACTGGTTTTCACATTAGAA GACAATTGACAACAGTTACATAATTCACTCTGAGTGTTTTATGAGAAAGCCTTCTTTTGGGGGTCAACAGTTTTCCTATGCTTTGAAACA GAAAAATATGTACCAAGAATCTTGGTTTGCCTTCCAGAAAACAAAACTGCATTTCACTTTCCCGGTGTTCCCCACTGTATCTAGGCAACA TAGTATTCATGACTATGGATAAACTAAACACGTGACACAAACACACACAAAAGGGAACCCAGCTCTAATACATTCCAACTCGTATAGCAT GCATCTGTTTATTCTATAGTTATTAAGTTCTTTAAAATGTAAAGCCATGCTGGAAAATAATACTGCTGAGATACATACAGAATTACTGTA ACTGATTACACTTGGTAATTGTACTAAAGCCAAACATATATATACTATTAAAAAGGTTTACAGAATTTTATGGTGCATTACGTGGGCATT GTCTTTTTAGATGCCCAAATCCTTAGATCTGGCATGTTAGCCCTTCCTCCAATTATAAGAGGATATGAACTGAGTTTTTCTTTTGTTGTT TGTTCTTAGCTGTAATTCCTATGCTTCTATTTCAGAGAGCCAGGAGAGTTTGATATTAAAGGAGGTTAAAACTGTGATCTTATGCCATGT CATCAATGGCCACTTAGGGGCCATGGCTGATGACACATTCTTATCTCTACAGTACTAATGTGTTATTATAGAGCCATGCATTTTATTTCT GAATAAGAACATATTTAAACTAATATTCCCTTACAATATGGACAGTATTAATCCTTCCAAGATGCAGTATTTATCAAGTGAAGCATATTT AGCAGCAAATTCCATTTTAACATAACTTAGGAACCAATAACCAGGGTGTTTTGTGGTTGGGGGAGGCACGGGGTGGAGTATTCTTTTTTA TATCCTCAAAACAAAAAAAATCAATACTTATATTTCAATGGCAATCTAGTATTTTTTTAAAAGACTGTATAGGCATGAATAATAGAGGTG GTTTGAGTTTTGTAGGGCCATCACCTGGAAAGTCAATGTGACTAGACACAAAGTAGCCCAGAGGCTACTTTTCTTCCTACAGCTTATTAT AGTTGTAGGTTCTATGACCTCACTTCATGGGTTCCAGGCAATTCCGCTGAAAGGTTTGTCTCCTGAAATTTTTTAAGTTTGTTTTCCTGA CACATGTAATCAGATGTGTAGCAACCGAGGGAAACGAAGCCTAACATTCTCCATTGTGGAAATACACACAGGAGGTTACATTTCACAGCG TGGATTTTTCCAGCTTACACATGTGGGATGACATCACAGAAACCACAAAAGCAGCAAATTAAACTGTAGGAGAGTCAATACTCCTGACGA GTCTCGGGGGGGGGGCATTTTTATGCCTTCTTAACTTTATGAGAATTCTCAGGCTGAACTATAGGCCATTGTTCCCAGGCAAATCAATAC ATCAATGCATCCTCAAAAAAAAAAAAAAAAAAAAAAAACCGGCTAAAACTGTGTCAAAATGTTCTTAAGGAGCCTATGGTCTCCACGGTG CTAAAAAGAGCCTGGTGCTGGGCCGACTGGCAGGGCTGAGCATCCTCCTGCCCCCTCGCCACTGATGTTTACTAAGCACTCTGAGCCAAT GAGACCCCCAGCAGCAGAAAGGGCACAAGGTGGCGCCAGGGCAGCAGGGCCAGATCTTTCTCATGCACCTCGACCTCTTGCAGACTTTCT TCGTGAGATGTACTACTCATTTCAAAACTGCTTTGCAGGGCTCCCCTATGTATTCGGGGGGCCCACGGCACACTCAGGCTGGAGATCCTT CCTCACTGCGCTCAAGATGGCCTCAGCCAGACACCAGTTACCCAGCTGAAAGTCACAATCCCTCCCAGAAGTCTCCCAACACTAGTGCTG ACCAGAGGTGGGGCTCTCAGGCTAGGAGTTTCACACACAATGACAGGCTGCTGGGGGACATTGCAGGACCCCTTTTCCTCTCCTCTCCAT GCTAGAAGCCAGCCCTAGGCAGCTGCAGTTACTCCCTGTGACTCAGCAGCAGGCTGATTCAACACAGCTGCCCACACAAAGCCAGTGGCT AATACATCTGTTTACCTTTCCCTATCACCCAGACACAAGCCCCTTTCCCAGGTCAAACCACAGGCCGATGCATCTCCAGTTTGACAGTCA AATCACTACTTCCATTGCTACTTTAGATCAGCCAAAGTGGTGACTGCTGCAGTGTGTGGCTATCCCTACAAGGCCCACCCAAGGGATGCC CAAAGCCCAACCTTCTCCAGGGCTGCAGCCCAGAGCAACCCCACCAGCCTAAGTCCAGCAGAGGACCTCCCACCCAATGTCTTGTTCTAA TTAGAAGGGGAAGTTAGCCACAGAAAATCAACTTATCTATAATTACAAAATTCTCTTGACTCACCTTAAAGTTCCTATTGACATCTACTG CTTTTAAACCTATTTGAAAACTCTGATACTAAAACAAATGACACTCTAAGAAAGTTTGGGAGCCCCATGCTGAGAACCATTTCTGTGCAG TGAGGATGTTTCCAGAAGCTACTTACCTACATGTGAATGTGCCATTTTCTTTCCTTTTGTAGAGAAAATCCCCTTTACTTTTTGGAACAG TAATGGCAGCTTCTAGTACAGCCATTACAGTTTCATATGAGAAAAATTAAGAATAACTATAAAATTGTTAAAATATCCAATAATGGATAA TGATGGCCAGAAGATTTAACATACAAAGTAATTCTCAATGTAAAGCTATTCAGCTCTTCCAGGTTGAATGCCCTGTAACCCACCCTGACC TTCCACATCATCTTCAAAAAGCAGTTTCTCTGTTCCCCATGATTCTCCTATAAGGTAACTCTTTAGTCCTCCATTTAGCACATTTTAAAT CCTCCAAAGAATAAGTATCATGTGATTATTTTAGCTTTACAAAAAAAAAGTTGAATGGCGTTTTATTTTCATGGCCTATAAGCAGGTACC TTAGTAGGGCAGATATAGGAAAAACAAATTAGAGCAAAACAAATCCTCTACAAATCCAAGGCAGGAAAAGTGGTGGCAGAGTGACTCATT CTCCTGTCCCTCCCATCAGGTCAAATCAGGAGGCTGCAGTGAATGCCTGTTCTTTGAATGTGTAGCAGTTGTTCCTGTAACTCTTTAAAA CTTGGCTATAGGCTGTTTAGCACAGTACAGATTAAAGATACAGTTACGTAAACAGCAAAGTAATTTTATAGTGCTTCATCCATTTATCAT GCTTTGGTTTGCTAATTTTTTCACATACCTTTTTCTATCACAGTCTGTTGCTTTTGTACACATTTCTCATATTGGGGTTCGACAGGTAAA >81064_81064_2_SF3B3-ADAM12_SF3B3_chr16_70604052_ENST00000302516_ADAM12_chr10_127967557_ENST00000368679_length(amino acids)=2017AA_BP=1170 MDIHTILLAAGFLGLRTVGVTKAWRSGWLRFPAAMFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTV EVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNR DAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLI TVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIR LKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLA NEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTL SCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVP PGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDL SDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRILALEKLGAVFNQ VAFPLQYTPRKFVIHPESNNLIIIETDHNAYTEATKAQRKQQMAEEMVEAAGEDERELAAEMAAAFLNENLPESIFGAPKAGNGQWASVI RVMNPIQGNTLDLVQLEQNEAAFSVAVCRFSNTGEDWYVLVGVAKDLILNPRSVAGGFVYTYKLVNNGEKLEFLHKTPVEEVPAAIAPFQ GRVLIGVGKLLRVYDLGKKKLLRKCENKHIANYISGIQTIGHRVIVSDVQESFIWVRYKRNENQLIIFADDTYPRWVTTASLLDYDTVAG ADKFGNICVVRLPPNTNDEVDEDPTGNKALWDRGLLNGASQKAEVIMNYHVGETVLSLQKTTLIPGGSESLVYTTLSGGIGILVPFTSHE NHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCYYHGHVRGYSDSAVSLSTCSGLRGLIVFENESY VLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLI EIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGG IVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESF GGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGH SCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIE TNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGF GGSTDSGPIRQADNQGLTIGILVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDS YPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHA -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SF3B3-ADAM12 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 105_119 | 1136.0 | 1218.0 | PHF5A%2C SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 145_168 | 1136.0 | 1218.0 | PHF5A%2C SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 193_231 | 1136.0 | 1218.0 | SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 786_804 | 1136.0 | 1218.0 | SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 1028_1049 | 1136.0 | 1218.0 | SF3B1 |
| Hgene | SF3B3 | chr16:70604052 | chr10:127967557 | ENST00000302516 | + | 24 | 26 | 1100_1123 | 1136.0 | 1218.0 | SF3B5 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SF3B3-ADAM12 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SF3B3-ADAM12 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0036341 | Schizophrenia | 1 | PSYGENET |
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