![]() |
||||||
|
![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:ABCA6-LIG3 (FusionGDB2 ID:HG23460TG3980) |
Fusion Gene Summary for ABCA6-LIG3 |
![]() |
Fusion gene information | Fusion gene name: ABCA6-LIG3 | Fusion gene ID: hg23460tg3980 | Hgene | Tgene | Gene symbol | ABCA6 | LIG3 | Gene ID | 23460 | 3980 |
Gene name | ATP binding cassette subfamily A member 6 | DNA ligase 3 | |
Synonyms | EST155051 | LIG2|LIG3alpha | |
Cytomap | ('ABCA6')('LIG3') 17q24.2-q24.3 | 17q12 | |
Type of gene | protein-coding | protein-coding | |
Description | ATP-binding cassette sub-family A member 6ABC transporter ABCA6ATP-binding cassette A6ATP-binding cassette, sub-family A (ABC1), member 6 | DNA ligase 3ligase II, DNA, ATP-dependentligase III, DNA, ATP-dependentpolydeoxyribonucleotide synthase [ATP] 3 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q8N139 | P49916 | |
Ensembl transtripts involved in fusion gene | ENST00000284425, ENST00000446604, ENST00000590645, | ||
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 6 X 4=144 |
# samples | 2 | 6 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ABCA6 [Title/Abstract] AND LIG3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | ABCA6(67102264)-LIG3(33323083), # samples:2 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | LIG3 | GO:0006288 | base-excision repair, DNA ligation | 19589734 |
Tgene | LIG3 | GO:0006302 | double-strand break repair | 19589734 |
Tgene | LIG3 | GO:0033151 | V(D)J recombination | 9809069 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BRCA | TCGA-A2-A0T1-01A | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
Top |
Fusion Gene ORF analysis for ABCA6-LIG3 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000284425 | ENST00000262327 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-3CDS | ENST00000284425 | ENST00000378526 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-3CDS | ENST00000446604 | ENST00000262327 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-3CDS | ENST00000446604 | ENST00000378526 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-3CDS | ENST00000590645 | ENST00000262327 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-3CDS | ENST00000590645 | ENST00000378526 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-intron | ENST00000284425 | ENST00000586407 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-intron | ENST00000446604 | ENST00000586407 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
intron-intron | ENST00000590645 | ENST00000586407 | ABCA6 | chr17 | 67102264 | - | LIG3 | chr17 | 33323083 | + |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
Top |
Fusion Genomic Features for ABCA6-LIG3 |
![]() |
Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
Top |
Fusion Protein Features for ABCA6-LIG3 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:67102264/:33323083) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
ABCA6 | LIG3 |
FUNCTION: Probable transporter which may play a role in macrophage lipid transport and homeostasis. {ECO:0000305|PubMed:10639163}. | FUNCTION: Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). {ECO:0000269|PubMed:10207110, ECO:0000269|PubMed:24674627}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
Fusion Gene Sequence for ABCA6-LIG3 |
![]() |
Top |
Fusion Gene PPI Analysis for ABCA6-LIG3 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for ABCA6-LIG3 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | LIG3 | P49916 | DB00290 | Bleomycin | Inhibitor | Small molecule | Approved|Investigational |
Top |
Related Diseases for ABCA6-LIG3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ABCA6 | C0009402 | Colorectal Carcinoma | 1 | CTD_human |
Hgene | ABCA6 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | ABCA6 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |