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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ACAP2-ATP13A3 (FusionGDB2 ID:HG23527TG79572)

Fusion Gene Summary for ACAP2-ATP13A3

check button Fusion gene summary
Fusion gene informationFusion gene name: ACAP2-ATP13A3
Fusion gene ID: hg23527tg79572
HgeneTgene
Gene symbol

ACAP2

ATP13A3

Gene ID

23527

79572

Gene nameArfGAP with coiled-coil, ankyrin repeat and PH domains 2ATPase 13A3
SynonymsCENTB2|CNT-B2AFURS1
Cytomap('ACAP2')('ATP13A3')

3q29

3q29

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2probable cation-transporting ATPase 13A3ATPase family homolog up-regulated in senescence cells 1ATPase type 13A3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000326793, ENST00000472860, 
Fusion gene scores* DoF score16 X 14 X 11=24647 X 9 X 5=315
# samples 2211
** MAII scorelog2(22/2464*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/315*10)=-1.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACAP2 [Title/Abstract] AND ATP13A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACAP2(195101738)-ATP13A3(194134568), # samples:1
Anticipated loss of major functional domain due to fusion event.ACAP2-ATP13A3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-ATP13A3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACAP2

GO:0030029

actin filament-based process

11062263


check buttonFusion gene breakpoints across ACAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATP13A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-85-8277ACAP2chr3

195101738

-ATP13A3chr3

194134568

-


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Fusion Gene ORF analysis for ACAP2-ATP13A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000326793ENST00000256031ACAP2chr3

195101738

-ATP13A3chr3

194134568

-
In-frameENST00000326793ENST00000439040ACAP2chr3

195101738

-ATP13A3chr3

194134568

-
intron-3CDSENST00000472860ENST00000256031ACAP2chr3

195101738

-ATP13A3chr3

194134568

-
intron-3CDSENST00000472860ENST00000439040ACAP2chr3

195101738

-ATP13A3chr3

194134568

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000326793ACAP2chr3195101738-ENST00000439040ATP13A3chr3194134568-4042516213794193
ENST00000326793ACAP2chr3195101738-ENST00000256031ATP13A3chr3194134568-4034516213794193

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326793ENST00000439040ACAP2chr3195101738-ATP13A3chr3194134568-0.0008632010.99913687
ENST00000326793ENST00000256031ACAP2chr3195101738-ATP13A3chr3194134568-0.0008865390.9991135

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Fusion Genomic Features for ACAP2-ATP13A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ACAP2-ATP13A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:195101738/chr3:194134568)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATP13A3chr3:195101738chr3:194134568ENST0000025603129321144_116411341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000043904030331144_116411341227.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-4231_22695779.0DomainNote=BAR
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423266_36195779.0DomainPH
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423399_52095779.0DomainArf-GAP
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423640_66995779.0RepeatNote=ANK 1
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423673_70295779.0RepeatNote=ANK 2
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423706_73595779.0RepeatNote=ANK 3
HgeneACAP2chr3:195101738chr3:194134568ENST00000326793-423414_43795779.0Zinc fingerC4-type
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932231_23411341227.0Compositional biasNote=Poly-Tyr
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033231_23411341227.0Compositional biasNote=Poly-Tyr
TgeneATP13A3chr3:195101738chr3:194134568ENST0000025603129321000_102011341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000025603129321074_109411341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000025603129321106_112611341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932206_22611341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932233_25311341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST00000256031293229_4911341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932410_43011341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932449_46911341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932941_96111341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000002560312932963_98311341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000043904030331000_102011341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000043904030331074_109411341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST0000043904030331106_112611341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033206_22611341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033233_25311341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST00000439040303329_4911341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033410_43011341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033449_46911341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033941_96111341227.0TransmembraneHelical
TgeneATP13A3chr3:195101738chr3:194134568ENST000004390403033963_98311341227.0TransmembraneHelical


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Fusion Gene Sequence for ACAP2-ATP13A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1213_1213_1_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000256031_length(transcript)=4034nt_BP=516nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATAGTGTGTGTACCATATCAGTGG
CGTGTAACTATGCTCATCATTGTTCTTGTCAATGCCTTTGTGTCTATCACAGTGGAGGAGTCAGTGGATCGGTGGGGAAAATGCTGCTTA
CCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAGCTCTTGGTTGATCCAGAATGGCCACCA
AAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATCACCATAACATAGCAGTGAATCAGTCTC
AGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGTCAGAATGGCACTAGTTCAGTTTATGTC
CCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATATATCGTCCTAACAGTTAAATTAACAATC
AATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTCTTGATTGTTACTTTCAGTGATATTCTT
TATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAGTTTACCTCTTCACATTTATGCTCACAA
CCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAGATGAGTGTTAATTAGCCTCCAGTGAAA
ATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACATATGCCAATTCCCTATGATGGTCTAGAG
TTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTTATATTTTCTGTACAAACTGCCTGGGTT
TTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAATGGCTCCTGTGCTATGTGTGGTGTTGGC
AGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCTTTCGGCAGTAGATGTAGATTCATCTTT
TAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTTTCTTCTATGTTTTCAATTACCTAAAGA
CATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGTATGTCTCTGTCTTATCAATAATGAGGC
TTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTGTTTTATGCCATTAGGTGGCGCCAGAGG
TCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTGGGAGAAAAAAAATTGAGGAAATAAAGT
TAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTGGCCTGATTAACATTTAAATTCTTGCCA
AAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCACAGTTACCACAACACAGAAAACTGATCG
TGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCCAGTAACATGCTTGCTCGTGCTTTCTAC
TTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTTTAGGACCAAATGGTTCTCACTCTTTAT
GCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACTGTTACTGCTATTGCCACTGATGATTCC
TGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGATAACAGTTGTTCCATGAATGATTCTAT
GAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTCTCTGGATCATTTTATAATTTCCATATT
AATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGTTTAAGTACTGAAGCATATAATGAAAGT
AATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATGATCATAAAGAGCTATTTTTGACACCCC
CCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTTTCAAAGGAATGAGGTGTTTAGGTGGCT
GGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAATGTTATTTGAAGAATGCCTGTGAAGCCA
GGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATAGTAATTTTGATTCTGAATTTCACATTA
AATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTAAGATGAATATTGCTGATTTAAATTTTA
TTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAACTTTTTAACTTTTTAAATAAATAACAA
GATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATAGTGGTAACTATATGTTTTGTATCTTCT
AGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAACAGAATAAATACTTTTATAGTAGTTTT
ATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTTTTACTCTATTTATTTTGTTCCCCATGT
TTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTGTTACAGAAACAGCTATAGATAACATTA
TCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAAAAATAGGTTTTTGTATATTTATGGTGG
GAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTACACATTTTTAATGTATTAAAATTTGGTA
ATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACCTTGGATTTTTTTAAGTAACTTTATATC
AGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTTGTCAAAAAGGCATACATTCATAATTGT

>1213_1213_1_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000256031_length(amino acids)=193AA_BP=101
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTIVCVPYQWRVTMLIIVLVNAFVSITVEESVDRWGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKAL

--------------------------------------------------------------
>1213_1213_2_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000439040_length(transcript)=4042nt_BP=516nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATAGTGTGTGTACCATATCAGTGG
CGTGTAACTATGCTCATCATTGTTCTTGTCAATGCCTTTGTGTCTATCACAGTGGAGGAGTCAGTGGATCGGTGGGGAAAATGCTGCTTA
CCCTGGGCCCTGGGCTGTAGAAAGAAGACACCAAAGGCAAAGTACATGTATCTGGCGCAGGAGCTCTTGGTTGATCCAGAATGGCCACCA
AAACCTCAGACAACCACAGAAGCTAAAGCTTTAGTTAAGGAGAATGGATCATGTCAAATCATCACCATAACATAGCAGTGAATCAGTCTC
AGTGGTATTGCTGATAGCAGTATTCAGGAATATGTGATTTTAGGAGTTTCTGATCCTGTGTGTCAGAATGGCACTAGTTCAGTTTATGTC
CCTTCTGATATAGTAGCTTATTTGACAGCTTTGCTCTTCCTTAAAATAAAAACAGAAAAATATATCGTCCTAACAGTTAAATTAACAATC
AATCCATAAAGTCCTATATCTTCATTCAGCAACCCAAATATTACATACATTTCCAGAATTTTCTTGATTGTTACTTTCAGTGATATTCTT
TATATTGGGTACAGGAGAAGTTTGGTGTTTGGTAGGTTTTTCAACATTAGTTTTTGAGACTAGTTTACCTCTTCACATTTATGCTCACAA
CCCTCTTGTTAGAAAAGTCTGTGTTTATATACAGGCTGTAAGTTTGTGATTGATAAAAAGAAGATGAGTGTTAATTAGCCTCCAGTGAAA
ATATACTGAAAGCCTGTTTTCATTTGATTCCAATGTTTCTTCCAAAGAATTCTGTATAAACATATGCCAATTCCCTATGATGGTCTAGAG
TTAGGAATGAGTGTTTATGGTGTTGCTTATAGAACAACTCAGGTAATCTCCATTTCTGGTTTTATATTTTCTGTACAAACTGCCTGGGTT
TTATTTTTCTAATCAGCAAGGTGCTTCACTGCCTTCTTGAGACGCCTCTCAAAGCTCTTAAATGGCTCCTGTGCTATGTGTGGTGTTGGC
AGTCTAATTTGCTTCTGTTAAATGTTGTAGAACCTTTTTCACTAGGAAATAAGATTCATTTCTTTCGGCAGTAGATGTAGATTCATCTTT
TAACGTTTCTTCAAATTTGTTTCTGTCAGGCTTTGTGTTATTTTAAATGGTTTTTTAAAATTTTCTTCTATGTTTTCAATTACCTAAAGA
CATAGGATAATAGTTTTTTTTAAGTTAGAATTTTACCTCATAAAATTTTTTGAGGTTTGATGTATGTCTCTGTCTTATCAATAATGAGGC
TTAAAAAATACTGGATTTGAATGGCTGCCGTTTTTTCAAAGCAATATGAATTTGATGAGTTTGTTTTATGCCATTAGGTGGCGCCAGAGG
TCAGAACATGTCTATTTTGAATTGGATCGTTACAAATGAGCATATTTGATGCGGAAATTTCTGGGAGAAAAAAAATTGAGGAAATAAAGT
TAAAAAATTGACATTCATTGAGCCAAAAGAGATGTGGAGAAACATTTTTCACCTTTCTGTTTGGCCTGATTAACATTTAAATTCTTGCCA
AAATTAAGGTAACTTTTAAAAAACACCTTTTATAGGTGGATCCAGCAGTCTGGCAACGCCCACAGTTACCACAACACAGAAAACTGATCG
TGCTATAAAATGGACGCTAAACTATGAAAACAGTGTGACATTGTTCTCTGTTCTTCCAGAGCCAGTAACATGCTTGCTCGTGCTTTCTAC
TTCTAGCTGATCATTCTTTTCCCAACATATATTTACAAATTTACCAAATTTTACCTAGAATTTTAGGACCAAATGGTTCTCACTCTTTAT
GCTGCAAAGACCTGGATGATGTTTGGTAACTATAGAAAAATAGAAATTACACTCAGGATCACTGTTACTGCTATTGCCACTGATGATTCC
TGCAAAAATATAATCGAAGTTTTCCATCAAATGTATAATATGCTATTAATACACATTAGATGATAACAGTTGTTCCATGAATGATTCTAT
GAAGCTATGCATCTTAGACCTCTTGAGCTGTGAATTAGCACTATTTTCTATAGTTACTTATTCTCTGGATCATTTTATAATTTCCATATT
AATTTCAAATATGCTCGTGTTATTCTTCAGTGATTTCCACAATTGTGCATTTTATTCTTTGGTTTAAGTACTGAAGCATATAATGAAAGT
AATTGCTAAGTAGCAGCTTAAAAATTCAATTATCCGATTGTATTTAACATCTTTAAGAGCATGATCATAAAGAGCTATTTTTGACACCCC
CCCCCCACTTTTTTAACATTTAGAGTTAGTAAGGGTTTTATATCTCTTCTGTCCATATTGTTTTCAAAGGAATGAGGTGTTTAGGTGGCT
GGAAAAGCATTTGTAGGAAGTTAGATTTGAATATAGACAAGGTGGGTTATTCACGTTGAGAATGTTATTTGAAGAATGCCTGTGAAGCCA
GGTGTGGGTTCTACTCAGTGCCATAGATAGACTGAGTCTTCTCTCGTAGGTTACCATTACATAGTAATTTTGATTCTGAATTTCACATTA
AATTATTTGAGTTTATACAGACCTAAATTTTAAAATCTGTACATATATTATTTTGATGTATTAAGATGAATATTGCTGATTTAAATTTTA
TTTATGCACATACTTAAAGGACAGAAATGTCTGGGAAAGTAATTGTTAAATAATGATATGTAACTTTTTAACTTTTTAAATAAATAACAA
GATTTTTAATGTGTGTCTCCCTCAGGGTTGTTTAAAGTTTTTTTTCTCCCTCAAGTATAAATAGTGGTAACTATATGTTTTGTATCTTCT
AGCACCAACTGCTGTAAAGCAATGCTGCAAATAATGCTTGAATACAAGTGGCTAAGCCAACAACAGAATAAATACTTTTATAGTAGTTTT
ATAATCCTGAAATTCGAAAGCTTTCCCAATTGCACTTGCATCTAAACAAAACTGTTGCAGTTTTTACTCTATTTATTTTGTTCCCCATGT
TTATGAAAGTCCTGCACAGTTTCAAAGGCATGGTAAATAATATATCAATGTTTATGTAGTCTGTTACAGAAACAGCTATAGATAACATTA
TCCAGTGAAGAGCAAAATTCAAGCTTTAGAAAATATTCATGCATGCAATTTTGACATATCTAAAAATAGGTTTTTGTATATTTATGGTGG
GAGGTGGTTGGGAACTTTTAACAAAATGGGGTGTTAATTTTTGTACAGTCTGTGGGCATTTACACATTTTTAATGTATTAAAATTTGGTA
ATTATGTGTACATTAAATTAATAAAAGTTACTTCTAGTTATGATTTGTGAATTCCCTAAGACCTTGGATTTTTTTAAGTAACTTTATATC
AGAAATGATACTGCATCTTTATATTTTTAAAATTGTATTGCTGCTCAAGAATGGTACCCTCTTGTCAAAAAGGCATACATTCATAATTGT

>1213_1213_2_ACAP2-ATP13A3_ACAP2_chr3_195101738_ENST00000326793_ATP13A3_chr3_194134568_ENST00000439040_length(amino acids)=193AA_BP=101
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTIVCVPYQWRVTMLIIVLVNAFVSITVEESVDRWGKCCLPWALGCRKKTPKAKYMYLAQELLVDPEWPPKPQTTTEAKAL

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Fusion Gene PPI Analysis for ACAP2-ATP13A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACAP2-ATP13A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACAP2-ATP13A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0340543Familial primary pulmonary hypertension1GENOMICS_ENGLAND
TgeneC11509292-oxo-hept-3-ene-1,7-dioate hydratase activity1GENOMICS_ENGLAND