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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ACAP2-TP63 (FusionGDB2 ID:HG23527TG8626)

Fusion Gene Summary for ACAP2-TP63

check button Fusion gene summary
Fusion gene informationFusion gene name: ACAP2-TP63
Fusion gene ID: hg23527tg8626
HgeneTgene
Gene symbol

ACAP2

TP63

Gene ID

23527

8626

Gene nameArfGAP with coiled-coil, ankyrin repeat and PH domains 2tumor protein p63
SynonymsCENTB2|CNT-B2AIS|B(p51A)|B(p51B)|EEC3|KET|LMS|NBP|OFC8|RHS|SHFM4|TP53CP|TP53L|TP73L|p40|p51|p53CP|p63|p73H|p73L
Cytomap('ACAP2')('TP63')

3q29

3q28

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2Arf GAP with coiled coil, ANK repeat and PH domains 2centaurin-beta-2tumor protein 63amplified in squamous cell carcinomachronic ulcerative stomatitis proteinkeratinocyte transcription factor KETtransformation-related protein 63tumor protein p53-competing protein
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000326793, ENST00000472860, 
Fusion gene scores* DoF score16 X 14 X 11=246413 X 11 X 8=1144
# samples 2215
** MAII scorelog2(22/2464*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1144*10)=-2.93105264628251
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ACAP2 [Title/Abstract] AND TP63 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACAP2(195065988)-TP63(189455529), # samples:1
Anticipated loss of major functional domain due to fusion event.ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACAP2-TP63 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneACAP2

GO:0030029

actin filament-based process

11062263

TgeneTP63

GO:0045747

positive regulation of Notch signaling pathway

11641404

TgeneTP63

GO:0045892

negative regulation of transcription, DNA-templated

12446784

TgeneTP63

GO:0045893

positive regulation of transcription, DNA-templated

12446784|16343436

TgeneTP63

GO:0045944

positive regulation of transcription by RNA polymerase II

22521434

TgeneTP63

GO:2000271

positive regulation of fibroblast apoptotic process

9774969


check buttonFusion gene breakpoints across ACAP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TP63 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-GD-A2C5-11AACAP2chr3

195065988

-TP63chr3

189455529

+


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Fusion Gene ORF analysis for ACAP2-TP63

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000326793ENST00000354600ACAP2chr3

195065988

-TP63chr3

189455529

+
5CDS-intronENST00000326793ENST00000392461ACAP2chr3

195065988

-TP63chr3

189455529

+
5CDS-intronENST00000326793ENST00000392463ACAP2chr3

195065988

-TP63chr3

189455529

+
5CDS-intronENST00000326793ENST00000437221ACAP2chr3

195065988

-TP63chr3

189455529

+
5CDS-intronENST00000326793ENST00000449992ACAP2chr3

195065988

-TP63chr3

189455529

+
5CDS-intronENST00000326793ENST00000456148ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000264731ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000320472ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000382063ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000392460ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000418709ACAP2chr3

195065988

-TP63chr3

189455529

+
In-frameENST00000326793ENST00000440651ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000264731ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000320472ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000382063ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000392460ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000418709ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-3CDSENST00000472860ENST00000440651ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000354600ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000392461ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000392463ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000437221ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000449992ACAP2chr3

195065988

-TP63chr3

189455529

+
intron-intronENST00000472860ENST00000456148ACAP2chr3

195065988

-TP63chr3

189455529

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326793ACAP2chr3195065988-ENST00000264731TP63chr3189455529+53335752132555780
ENST00000326793ACAP2chr3195065988-ENST00000382063TP63chr3189455529+50785752132300695
ENST00000326793ACAP2chr3195065988-ENST00000418709TP63chr3189455529+32955752131976587
ENST00000326793ACAP2chr3195065988-ENST00000320472TP63chr3189455529+25175752132045610
ENST00000326793ACAP2chr3195065988-ENST00000392460TP63chr3189455529+21815752132180655
ENST00000326793ACAP2chr3195065988-ENST00000440651TP63chr3189455529+25445752132543776

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326793ENST00000264731ACAP2chr3195065988-TP63chr3189455529+0.0002927250.9997073
ENST00000326793ENST00000382063ACAP2chr3195065988-TP63chr3189455529+0.0003559450.99964404
ENST00000326793ENST00000418709ACAP2chr3195065988-TP63chr3189455529+0.0004043910.9995956
ENST00000326793ENST00000320472ACAP2chr3195065988-TP63chr3189455529+0.0055002680.9944997
ENST00000326793ENST00000392460ACAP2chr3195065988-TP63chr3189455529+0.0069191850.9930808
ENST00000326793ENST00000440651ACAP2chr3195065988-TP63chr3189455529+0.0069528060.9930472

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Fusion Genomic Features for ACAP2-TP63


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ACAP2chr3195065987-TP63chr3189455528+0.0012998880.99870014
ACAP2chr3195065987-TP63chr3189455528+0.0012998880.99870014

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ACAP2-TP63


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:195065988/chr3:189455529)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014437_44420681.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012437_44420511.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012437_4440587.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013437_44420596.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013437_44420556.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010437_4440417.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011437_4440462.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011437_44420488.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109437_4440394.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014437_44420677.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011437_4440502.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012437_4440583.0Compositional biasNote=Poly-Gln
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014170_36220681.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012170_36220511.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012170_3620587.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013170_36220596.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013170_36220556.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010170_3620417.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011170_3620462.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011170_36220488.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109170_3620394.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014170_36220677.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011170_3620502.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012170_3620583.0DNA binding.
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014541_60720681.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012541_60720511.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012541_6070587.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013541_60720596.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013541_60720556.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010541_6070417.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011541_6070462.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011541_60720488.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109541_6070394.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014541_60720677.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011541_6070502.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012541_6070583.0DomainNote=SAM
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014394_44320681.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014610_68020681.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012394_44320511.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012610_68020511.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003546000121_1070587.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012394_4430587.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012610_6800587.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013394_44320596.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013610_68020596.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013394_44320556.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013610_68020556.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003924610101_1070417.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010394_4430417.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010610_6800417.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000003924630111_1070462.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011394_4430462.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011610_6800462.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011394_44320488.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011610_68020488.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000437221091_1070394.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109394_4430394.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109610_6800394.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014394_44320677.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014610_68020677.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000004499920111_1070502.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011394_4430502.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011610_6800502.0RegionNote=Transactivation inhibition
TgeneTP63chr3:195065988chr3:189455529ENST000004561480121_1070583.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012394_4430583.0RegionNote=Oligomerization
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012610_6800583.0RegionNote=Transactivation inhibition

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-5231_226114779.0DomainNote=BAR
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523266_361114779.0DomainPH
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523399_520114779.0DomainArf-GAP
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523640_669114779.0RepeatNote=ANK 1
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523673_702114779.0RepeatNote=ANK 2
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523706_735114779.0RepeatNote=ANK 3
HgeneACAP2chr3:195065988chr3:189455529ENST00000326793-523414_437114779.0Zinc fingerC4-type
TgeneTP63chr3:195065988chr3:189455529ENST000002647310141_10720681.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003204720121_10720511.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003820630131_10720596.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000003924600131_10720556.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000004187090111_10720488.0RegionNote=Transcription activation
TgeneTP63chr3:195065988chr3:189455529ENST000004406510141_10720677.0RegionNote=Transcription activation


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Fusion Gene Sequence for ACAP2-TP63


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1225_1225_1_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000264731_length(transcript)=5333nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCG
TCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCG
GCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
CCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTG
AGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCC
ATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAAC
AGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGC
TTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAG
AACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAA
CTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAG
CACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATAT
GGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCAACGCC
CTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTC
AGCCCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAGCATT
GTCAGTTTCTTAGCGAGGTTGGGCTGTTCATCATGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTATCAGATTGAGCATTAC
TCCATGGATGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCACCGGCAGCTCCACGAA
TTCTCCTCCCCTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATT
GATGCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCTCGCCGC
AATAAGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTGAGCTCTTCCTATCCCTCTCCTAACTGCCAGCCCCCTAAAAG
CACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTCCCCTTCCTCTTGTCTGATTTCTTAGGGGAAGGAGAAGTAAGAGGCTACCT
CTTACCTAACATCTGACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCTTCAAAACTATAGCTTGCAGAACTGTAGCTGCCATGGCTAG
GTAGAAGTGAGCAAAAAAGAGTTGGGTGTCTCCTTAAGCTGCAGAGATTTCTCATTGACTTTTATAAAGCATGTTCACCCTTATAGTCTA
AGACTATATATATAAATGTATAAATATACAGTATAGATTTTTGGGTGGGGGGCATTGAGTATTGTTTAAAATGTAATTTAAATGAAAGAA
AATTGAGTTGCACTTATTGACCATTTTTTAATTTACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGGGTATCATGTATGGTG
ATAGGTATCTAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTTTCAGTTCTTTGGATTCTAAATACATGCCACATCAAA
CCTTTGAGTAGATCCATTTCCATTGCTTATTATGTAGGTAAGACTGTAGATATGTATTCTTTTCTCAGTGTTGGTATATTTTATATTACT
GACATTTCTTCTAGTGATGATGGTTCACGTTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTCATGTCCAAACGTCCTCTTTAGTTTTT
GGTTGGGAATGAGGAAAATTCTTAAAAGGCCCATAGCAGCCAGTTCAAAAACACCCGACGTCATGTATTTGAGCATATCAGTAACCCCCT
TAAATTTAATACCAGATACCTTATCTTACAATATTGATTGGGAAAACATTTGCTGCCATTACAGAGGTATTAAAACTAAATTTCACTACT
AGATTGACTAACTCAAATACACATTTGCTACTGTTGTAAGAATTCTGATTGATTTGATTGGGATGAATGCCATCTATCTAGTTCTAACAG
TGAAGTTTTACTGTCTATTAATATTCAGGGTAAATAGGAATCATTCAGAAATGTTGAGTCTGTACTAAACAGTAAGATATCTCAATGAAC
CATAAATTCAACTTTGTAAAAATCTTTTGAAGCATAGATAATATTGTTTGGTAAATGTTTCTTTTGTTTGGTAAATGTTTCTTTTAAAGA
CCCTCCTATTCTATAAAACTCTGCATGTAGAGGCTTGTTTACCTTTCTCTCTCTAAGGTTTACAATAGGAGTGGTGATTTGAAAAATATA
AAATTATGAGATTGGTTTTCCTGTGGCATAAATTGCATCACTGTATCATTTTCTTTTTTAACCGGTAAGAGTTTCAGTTTGTTGGAAAGT
AACTGTGAGAACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACATGAAAGGTCCCCACAGAGCAAGAGATAAGTCTTTCAT
GGCTGCTGTTGCTTAAACCACTTAAACGAAGAGTTCCCTTGAAACTTTGGGAAAACATGTTAATGACAATATTCCAGATCTTTCAGAAAT
ATAACACATTTTTTTGCATGCATGCAAATGAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGGGCTGTCATTGCACATAAGCTTCCATT
TTAATTTTAAAGTGCAAAAGGGCCAGCGTGGCTCTAAAAGGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATATATTTTGTGTGAAATT
GCATACTTTGTATTTTGATTATTTTTTTTTTCTTCTTGGGATAGTGGGATTTCCAGAACCACACTTGAAACCTTTTTTTATCGTTTTTGT
ATTTTCATGAAAATACCATTTAGTAAGAATACCACATCAAATAAGAAATAATGCTACAATTTTAAGAGGGGAGGGAAGGGAAAGTTTTTT
TTTATTATTTTTTTAAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATTTCAAAGTTTTGTTGTACTTAAATGGTAATAAGCACTGTAA
ACTTCTGCAACAAGCATGCAGCTTTGCAAACCCATTAAGGGGAAGAATGAAAGCTGTTCCTTGGTCCTAGTAAGAAGACAAACTGCTTCC
CTTACTTTGCTGAGGGTTTGAATAAACCTAGGACTTCCGAGCTATGTCAGTACTATTCAGGTAACACTAGGGCCTTGGAAATTCCTGTAC
TGTGTCTCATGGATTTGGCACTAGCCAAAGCGAGGCACCCTTACTGGCTTACCTCCTCATGGCAGCCTACTCTCCTTGAGTGTATGAGTA
GCCAGGGTAAGGGGTAAAAGGATAGTAAGCATAGAAACCACTAGAAAGTGGGCTTAATGGAGTTCTTGTGGCCTCAGCTCAATGCAGTTA
GCTGAAGAATTGAAAAGTTTTTGTTTGGAGACGTTTATAAACAGAAATGGAAAGCAGAGTTTTCATTAAATCCTTTTACCTTTTTTTTTT
CTTGGTAATCCCCTAAAATAACAGTATGTGGGATATTGAATGTTAAAGGGATATTTTTTTCTATTATTTTTATAATTGTACAAAATTAAG
CAAATGTTAAAAGTTTTATATGCTTTATTAATGTTTTCAAAAGGTATTATACATGTGATACATTTTTTAAGCTTCAGTTGCTTGTCTTCT
GGTACTTTCTGTTATGGGCTTTTGGGGAGCCAGAAGCCAATCTACAATCTCTTTTTGTTTGCCAGGACATGCAATAAAATTTAAAAAATA

>1225_1225_1_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000264731_length(amino acids)=780AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ
QQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLS
MPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTP

--------------------------------------------------------------
>1225_1225_2_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000320472_length(transcript)=2517nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCG
TCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCG
GCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
CCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTG
AGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCC
ATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAAC
AGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGC
TTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAG
AACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAA
CTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAG
CACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATAT
GGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCAACGCC
CTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACAGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAA
GGGCATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGG
CTCCAGTGAGACCCGGGGTGAGCGTGTTATTGATGCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAA
TGACTTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTGAGCTCTTCCT
ATCCCTCTCCTAACTGCCAGCCCCCTAAAAGCACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTCCCCTTCCTCTTGTCTGATT

>1225_1225_2_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000320472_length(amino acids)=610AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ

--------------------------------------------------------------
>1225_1225_3_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000382063_length(transcript)=5078nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAG
GTGATGACCCCACCTCCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGC
CCCAACCATGAGCTGAGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAG
TATGTAGAAGATCCCATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTAC
AATTTCATGTGTAACAGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTC
CTGGGCCGACGCTGCTTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTT
TCGGACAGTACAAAGAACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGA
TCCCCAGATGATGAACTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATG
CAGTACCTTCCTCAGCACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAG
TCTCCATCTTCATATGGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCT
CAGCAGCGCAACGCCCTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGA
GACATGAATGGACTCAGCCCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCC
ACAGATTGCAGCATTGTCAGTTTCTTAGCGAGGTTGGGCTGTTCATCATGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTAT
CAGATTGAGCATTACTCCATGGATGATCTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCAC
CGGCAGCTCCACGAATTCTCCTCCCCTTCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGG
GGTGAGCGTGTTATTGATGCTGTGCGATTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGAC
ATGGATGCTCGCCGCAATAAGCAACAGCGCATCAAAGAGGAGGGGGAGTGAGCCTCACCATGTGAGCTCTTCCTATCCCTCTCCTAACTG
CCAGCCCCCTAAAAGCACTCCTGCTTAATCTTCAAAGCCTTCTCCCTAGCTCCTCCCCTTCCTCTTGTCTGATTTCTTAGGGGAAGGAGA
AGTAAGAGGCTACCTCTTACCTAACATCTGACCTGGCATCTAATTCTGATTCTGGCTTTAAGCCTTCAAAACTATAGCTTGCAGAACTGT
AGCTGCCATGGCTAGGTAGAAGTGAGCAAAAAAGAGTTGGGTGTCTCCTTAAGCTGCAGAGATTTCTCATTGACTTTTATAAAGCATGTT
CACCCTTATAGTCTAAGACTATATATATAAATGTATAAATATACAGTATAGATTTTTGGGTGGGGGGCATTGAGTATTGTTTAAAATGTA
ATTTAAATGAAAGAAAATTGAGTTGCACTTATTGACCATTTTTTAATTTACTTGTTTTGGATGGCTTGTCTATACTCCTTCCCTTAAGGG
GTATCATGTATGGTGATAGGTATCTAGAGCTTAATGCTACATGTGAGTGACGATGATGTACAGATTCTTTCAGTTCTTTGGATTCTAAAT
ACATGCCACATCAAACCTTTGAGTAGATCCATTTCCATTGCTTATTATGTAGGTAAGACTGTAGATATGTATTCTTTTCTCAGTGTTGGT
ATATTTTATATTACTGACATTTCTTCTAGTGATGATGGTTCACGTTGGGGTGATTTAATCCAGTTATAAGAAGAAGTTCATGTCCAAACG
TCCTCTTTAGTTTTTGGTTGGGAATGAGGAAAATTCTTAAAAGGCCCATAGCAGCCAGTTCAAAAACACCCGACGTCATGTATTTGAGCA
TATCAGTAACCCCCTTAAATTTAATACCAGATACCTTATCTTACAATATTGATTGGGAAAACATTTGCTGCCATTACAGAGGTATTAAAA
CTAAATTTCACTACTAGATTGACTAACTCAAATACACATTTGCTACTGTTGTAAGAATTCTGATTGATTTGATTGGGATGAATGCCATCT
ATCTAGTTCTAACAGTGAAGTTTTACTGTCTATTAATATTCAGGGTAAATAGGAATCATTCAGAAATGTTGAGTCTGTACTAAACAGTAA
GATATCTCAATGAACCATAAATTCAACTTTGTAAAAATCTTTTGAAGCATAGATAATATTGTTTGGTAAATGTTTCTTTTGTTTGGTAAA
TGTTTCTTTTAAAGACCCTCCTATTCTATAAAACTCTGCATGTAGAGGCTTGTTTACCTTTCTCTCTCTAAGGTTTACAATAGGAGTGGT
GATTTGAAAAATATAAAATTATGAGATTGGTTTTCCTGTGGCATAAATTGCATCACTGTATCATTTTCTTTTTTAACCGGTAAGAGTTTC
AGTTTGTTGGAAAGTAACTGTGAGAACCCAGTTTCCCGTCCATCTCCCTTAGGGACTACCCATAGACATGAAAGGTCCCCACAGAGCAAG
AGATAAGTCTTTCATGGCTGCTGTTGCTTAAACCACTTAAACGAAGAGTTCCCTTGAAACTTTGGGAAAACATGTTAATGACAATATTCC
AGATCTTTCAGAAATATAACACATTTTTTTGCATGCATGCAAATGAGCTCTGAAATCTTCCCATGCATTCTGGTCAAGGGCTGTCATTGC
ACATAAGCTTCCATTTTAATTTTAAAGTGCAAAAGGGCCAGCGTGGCTCTAAAAGGTAATGTGTGGATTGCCTCTGAAAAGTGTGTATAT
ATTTTGTGTGAAATTGCATACTTTGTATTTTGATTATTTTTTTTTTCTTCTTGGGATAGTGGGATTTCCAGAACCACACTTGAAACCTTT
TTTTATCGTTTTTGTATTTTCATGAAAATACCATTTAGTAAGAATACCACATCAAATAAGAAATAATGCTACAATTTTAAGAGGGGAGGG
AAGGGAAAGTTTTTTTTTATTATTTTTTTAAAATTTTGTATGTTAAAGAGAATGAGTCCTTGATTTCAAAGTTTTGTTGTACTTAAATGG
TAATAAGCACTGTAAACTTCTGCAACAAGCATGCAGCTTTGCAAACCCATTAAGGGGAAGAATGAAAGCTGTTCCTTGGTCCTAGTAAGA
AGACAAACTGCTTCCCTTACTTTGCTGAGGGTTTGAATAAACCTAGGACTTCCGAGCTATGTCAGTACTATTCAGGTAACACTAGGGCCT
TGGAAATTCCTGTACTGTGTCTCATGGATTTGGCACTAGCCAAAGCGAGGCACCCTTACTGGCTTACCTCCTCATGGCAGCCTACTCTCC
TTGAGTGTATGAGTAGCCAGGGTAAGGGGTAAAAGGATAGTAAGCATAGAAACCACTAGAAAGTGGGCTTAATGGAGTTCTTGTGGCCTC
AGCTCAATGCAGTTAGCTGAAGAATTGAAAAGTTTTTGTTTGGAGACGTTTATAAACAGAAATGGAAAGCAGAGTTTTCATTAAATCCTT
TTACCTTTTTTTTTTCTTGGTAATCCCCTAAAATAACAGTATGTGGGATATTGAATGTTAAAGGGATATTTTTTTCTATTATTTTTATAA
TTGTACAAAATTAAGCAAATGTTAAAAGTTTTATATGCTTTATTAATGTTTTCAAAAGGTATTATACATGTGATACATTTTTTAAGCTTC
AGTTGCTTGTCTTCTGGTACTTTCTGTTATGGGCTTTTGGGGAGCCAGAAGCCAATCTACAATCTCTTTTTGTTTGCCAGGACATGCAAT

>1225_1225_3_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000382063_length(amino acids)=695AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNE
GQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARIC
ACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETY
RQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQAL
PPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSH

--------------------------------------------------------------
>1225_1225_4_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000392460_length(transcript)=2181nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCG
TCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCG
GCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
CCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTG
AGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCC
ATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAAC
AGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGC
TTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAG
AACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAA
CTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAG
CACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATAT
GGTAACAGCTCCCCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCAACGCC
CTCACTCCTACAACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTC
AGCCCCACCCAGGCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAGCATT

>1225_1225_4_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000392460_length(amino acids)=655AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ
QQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLS

--------------------------------------------------------------
>1225_1225_5_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000418709_length(transcript)=3295nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCG
TCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCG
GCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
CCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTG
AGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCC
ATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAAC
AGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGC
TTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAG
AACGGTGATGGTACGAAGCGCCCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAA
CTGTTATACTTACCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAG
CACACAATTGAAACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACATCTCCTTTCAGCCTGCTTCAGGAATGAG
CTTGTGGAGCCCCGGAGAGAAACTCCAAAACAATCTGACGTCTTCTTTAGACATTCCAAGCCCCCAAACCGATCAGTGTACCCATAGAGC
CCTATCTCTATATTTTAAGTGTGTGTGTTGTATTTCCATGTGTATATGTGAGTGTGTGTGTGTGTATGTGTGTGCGTGTGTATCTAGCCC
TCATAAACAGGACTTGAAGACACTTTGGCTCAGAGACCCAACTGCTCAAAGGCACAAAGCCACTAGTGAGAGAATCTTTTGAAGGGACTC
AAACCTTTACAAGAAAGGATGTTTTCTGCAGATTTTGTATCCTTAGACCGGCCATTGGTGGGTGAGGAACCACTGTGTTTGTCTGTGAGC
TTTCTGTTGTTTCCTGGGAGGGAGGGGTCAGGTGGGGAAAGGGGCATTAAGATGTTTATTGGAACCCTTTTCTGTCTTCTTCTGTTGTTT
TTCTAAAATTCACAGGGAAGCTTTTGAGCAGGTCTCAAACTTAAGATGTCTTTTTAAGAAAAGGAGAAAAAAGTTGTTATTGTCTGTGCA
TAAGTAAGTTGTAGGTGACTGAGAGACTCAGTCAGACCCTTTTAATGCTGGTCATGTAATAATATTGCAAGTAGTAAGAAACGAAGGTGT
CAAGTGTACTGCTGGGCAGCGAGGTGATCATTACCAAAAGTAATCAACTTTGTGGGTGGAGAGTTCTTTGTGAGAACTTGCATTATTTGT
GTCCTCCCCTCATGTGTAGGTAGAACATTTCTTAATGCTGTGTACCTGCCTCTGCCACTGTATGTTGGCATCTGTTATGCTAAAGTTTTT
CTTGTACATGAAACCCTGGAAGACCTACTACAAAAAAACTGTTGTTTGGCCCCCATAGCAGGTGAACTCATTTTGTGCTTTTAATAGAAA
GACAAATCCACCCCAGTAATATTGCCCTTACGTAGTTGTTTACCATTATTCAAAGCTCAAAATAGAATTTGAAGCCCTCTCACAAAATCT
GTGATTAATTTGCTTAATTAGAGCTTCTATCCCTCAAGCCTACCTACCATAAAACCAGCCATATTACTGATACTGTTCAGTGCATTTAGC
CAGGAGACTTACGTTTTGAGTAAGTGAGATCCAAGCAGACGTGTTAAAATCAGCACTCCTGGACTGGAAATTAAAGATTGAAAGGGTAGA
CTACTTTTCTTTTTTTTACTCAAAAGTTTAGAGAATCTCTGTTTCTTTCCATTTTAAAAACATATTTTAAGATAATAGCATAAAGACTTT
AAAAATGTTCCTCCCCTCCATCTTCCCACACCCAGTCACCAGCACTGTATTTTCTGTCACCAAGACAATGATTTCTTGTTATTGAGGCTG

>1225_1225_5_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000418709_length(amino acids)=587AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQ

--------------------------------------------------------------
>1225_1225_6_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000440651_length(transcript)=2544nt_BP=575nt
CGTTTCCCTGCGGCCAGCGCTCTACTTGGGGCGGGAGGAAGAGGGGCGGGACTGGGGCCTGACTAGTCGTCGCCGTCTTCGCGGCTGCTA
TGACCAGCGGGCGAGGCGCCCTTCGCAGCTCCGCGCAACGCTAGTCGCGGCCGTGCGCCCGCCGTAGCCGTCTGCGTCCCAGCGCGGCCG
CTCCCGCGGCCCCCTCGGCTTTGCCAGCGCCGCCTGCGAGGCGGAGGCAGGATGAAGATGACTGTGGATTTCGAGGAGTGTCTGAAGGAC
TCGCCCCGCTTCAGGGCAGCTTTGGAAGAAGTAGAAGGTGATGTGGCAGAATTGGAACTAAAACTTGATAAGCTTGTGAAACTTTGTATT
GCAATGATTGATACTGGAAAAGCCTTTTGTGTTGCAAATAAACAGTTCATGAATGGGATTCGAGACCTGGCTCAGTATTCTAGTAATGAT
GCTGTCGTTGAGACAAGTTTGACCAAGTTTTCTGACAGTCTTCAAGAAATGATAAATTTTCACACAATCCTGTTTGACCAAACTCAGAGA
TCAATTAAGGCACAGCTTCAGAACTTTGTTAAAGATTTCGTAGAAACCCCAGCTCATTTCTCTTGGAAAGAAAGTTATTACCGATCCACC
ATGTCCCAGAGCACACAGACAAATGAATTCCTCAGTCCAGAGGTTTTCCAGCATATCTGGGATTTTCTGGAACAGCCTATATGTTCAGTT
CAGCCCATTGACTTGAACTTTGTGGATGAACCATCAGAAGATGGTGCGACAAACAAGATTGAGATTAGCATGGACTGTATCCGCATGCAG
GACTCGGACCTGAGTGACCCCATGTGGCCACAGTACACGAACCTGGGGCTCCTGAACAGCATGGACCAGCAGATTCAGAACGGCTCCTCG
TCCACCAGTCCCTATAACACAGACCACGCGCAGAACAGCGTCACGGCGCCCTCGCCCTACGCACAGCCCAGCTCCACCTTCGATGCTCTC
TCTCCATCACCCGCCATCCCCTCCAACACCGACTACCCAGGCCCGCACAGTTTCGACGTGTCCTTCCAGCAGTCGAGCACCGCCAAGTCG
GCCACCTGGACGTATTCCACTGAACTGAAGAAACTCTACTGCCAAATTGCAAAGACATGCCCCATCCAGATCAAGGTGATGACCCCACCT
CCTCAGGGAGCTGTTATCCGCGCCATGCCTGTCTACAAAAAAGCTGAGCACGTCACGGAGGTGGTGAAGCGGTGCCCCAACCATGAGCTG
AGCCGTGAATTCAACGAGGGACAGATTGCCCCTCCTAGTCATTTGATTCGAGTAGAGGGGAACAGCCATGCCCAGTATGTAGAAGATCCC
ATCACAGGAAGACAGAGTGTGCTGGTACCTTATGAGCCACCCCAGGTTGGCACTGAATTCACGACAGTCTTGTACAATTTCATGTGTAAC
AGCAGTTGTGTTGGAGGGATGAACCGCCGTCCAATTTTAATCATTGTTACTCTGGAAACCAGAGATGGGCAAGTCCTGGGCCGACGCTGC
TTTGAGGCCCGGATCTGTGCTTGCCCAGGAAGAGACAGGAAGGCGGATGAAGATAGCATCAGAAAGCAGCAAGTTTCGGACAGTACAAAG
AACGGTGATGCGTTTCGTCAGAACACACATGGTATCCAGATGACATCCATCAAGAAACGAAGATCCCCAGATGATGAACTGTTATACTTA
CCAGTGAGGGGCCGTGAGACTTATGAAATGCTGTTGAAGATCAAAGAGTCCCTGGAACTCATGCAGTACCTTCCTCAGCACACAATTGAA
ACGTACAGGCAACAGCAACAGCAGCAGCACCAGCACTTACTTCAGAAACAGACCTCAATACAGTCTCCATCTTCATATGGTAACAGCTCC
CCACCTCTGAACAAAATGAACAGCATGAACAAGCTGCCTTCTGTGAGCCAGCTTATCAACCCTCAGCAGCGCAACGCCCTCACTCCTACA
ACCATTCCTGATGGCATGGGAGCCAACATTCCCATGATGGGCACCCACATGCCAATGGCTGGAGACATGAATGGACTCAGCCCCACCCAG
GCACTCCCTCCCCCACTCTCCATGCCATCCACCTCCCACTGCACACCCCCACCTCCGTATCCCACAGATTGCAGCATTGTCAGTTTCTTA
GCGAGGTTGGGCTGTTCATCATGTCTGGACTATTTCACGACCCAGGGGCTGACCACCATCTATCAGATTGAGCATTACTCCATGGATGAT
CTGGCAAGTCTGAAAATCCCTGAGCAATTTCGACATGCGATCTGGAAGGGCATCCTGGACCACCGGCAGCTCCACGAATTCTCCTCCCCT
TCTCATCTCCTGCGGACCCCAAGCAGTGCCTCTACAGTCAGTGTGGGCTCCAGTGAGACCCGGGGTGAGCGTGTTATTGATGCTGTGCGA
TTCACCCTCCGCCAGACCATCTCTTTCCCACCCCGAGATGAGTGGAATGACTTCAACTTTGACATGGATGCTCGCCGCAATAAGCAACAG

>1225_1225_6_ACAP2-TP63_ACAP2_chr3_195065988_ENST00000326793_TP63_chr3_189455529_ENST00000440651_length(amino acids)=776AA_BP=121
MRGGGRMKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFS
DSLQEMINFHTILFDQTQRSIKAQLQNFVKDFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWDFLEQPICSVQPIDLNFVDEP
SEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTD
YPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAP
PSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGR
DRKADEDSIRKQQVSDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQ
HLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPST
SHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHEFSSPSHLLRTPSSAS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ACAP2-TP63


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTP63chr3:195065988chr3:189455529ENST00000264731014352_38820.666666666666668681.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000320472012352_38820.666666666666668511.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000354600012352_3880587.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000382063013352_38820.666666666666668596.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000392460013352_38820.666666666666668556.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000392461010352_3880.0417.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000392463011352_3880.0462.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000418709011352_38820.666666666666668488.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST0000043722109352_3880.0394.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000440651014352_38820.666666666666668677.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000449992011352_3880.0502.0HIPK2
TgeneTP63chr3:195065988chr3:189455529ENST00000456148012352_3880.0583.0HIPK2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ACAP2-TP63


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ACAP2-TP63


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1785148RAPP-HODGKIN SYNDROME7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0406709Hay-Wells syndrome4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC1858562ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 34CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0008924Cleft upper lip3CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneC0406704Rudiger syndrome 13CTD_human;ORPHANET
TgeneC1863204ADULT SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0024121Lung Neoplasms2CTD_human
TgeneC0158646Cleft palate with cleft lip2ORPHANET
TgeneC0242379Malignant neoplasm of lung2CTD_human
TgeneC1298692Cleft lip and alveolus2ORPHANET
TgeneC1851841ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 12ORPHANET
TgeneC1854442SPLIT-HAND/FOOT MALFORMATION 42CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0000772Multiple congenital anomalies1CTD_human
TgeneC0001418Adenocarcinoma1CTD_human
TgeneC0005689Bladder Exstrophy1ORPHANET
TgeneC0006145Breast Diseases1CTD_human
TgeneC0007097Carcinoma1CTD_human
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007621Neoplastic Cell Transformation1CTD_human
TgeneC0008925Cleft Palate1CTD_human
TgeneC0009402Colorectal Carcinoma1CTD_human
TgeneC0009404Colorectal Neoplasms1CTD_human
TgeneC0016508Congenital Foot Deformity1CTD_human
TgeneC0018566Congenital Hand Deformities1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0030297Pancreatic Neoplasm1CTD_human
TgeneC0037268Skin Abnormalities1CTD_human
TgeneC0038987Sweat Gland Neoplasms1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0205641Adenocarcinoma, Basal Cell1CTD_human
TgeneC0205642Adenocarcinoma, Oxyphilic1CTD_human
TgeneC0205643Carcinoma, Cribriform1CTD_human
TgeneC0205644Carcinoma, Granular Cell1CTD_human
TgeneC0205645Adenocarcinoma, Tubular1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0206720Squamous Cell Neoplasms1CTD_human
TgeneC0206762Limb Deformities, Congenital1CTD_human
TgeneC0265554Ectrodactyly1ORPHANET
TgeneC0346647Malignant neoplasm of pancreas1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0751688Malignant Squamous Cell Neoplasm1CTD_human
TgeneC0919267ovarian neoplasm1CTD_human
TgeneC1140680Malignant neoplasm of ovary1CTD_human;UNIPROT
TgeneC1449718Endocrine Breast Diseases1CTD_human
TgeneC1720887Female Urogenital Diseases1CTD_human
TgeneC1837218Cleft palate, isolated1CTD_human
TgeneC1851878OROFACIAL CLEFT 81UNIPROT
TgeneC1863753LIMB-MAMMARY SYNDROME1CTD_human;GENOMICS_ENGLAND;ORPHANET