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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FPGS-VPS13C (FusionGDB2 ID:HG2356TG54832)

Fusion Gene Summary for FPGS-VPS13C

check button Fusion gene summary
Fusion gene informationFusion gene name: FPGS-VPS13C
Fusion gene ID: hg2356tg54832
HgeneTgene
Gene symbol

FPGS

VPS13C

Gene ID

2356

54832

Gene namefolylpolyglutamate synthasevacuolar protein sorting 13 homolog C
Synonyms-PARK23
Cytomap('FPGS')('VPS13C')

9q34.11

15q22.2

Type of geneprotein-codingprotein-coding
Descriptionfolylpolyglutamate synthase, mitochondrialfolylpoly-gamma-glutamate synthetasetetrahydrofolate synthasetetrahydrofolylpolyglutamate synthasevacuolar protein sorting-associated protein 13C
Modification date2020031320200313
UniProtAcc

Q05932

.
Ensembl transtripts involved in fusion geneENST00000460181, ENST00000373225, 
ENST00000373245, ENST00000373247, 
ENST00000393706, 
Fusion gene scores* DoF score6 X 6 X 5=1809 X 9 X 4=324
# samples 89
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/324*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FPGS [Title/Abstract] AND VPS13C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFPGS(130566979)-VPS13C(62148608), # samples:1
Anticipated loss of major functional domain due to fusion event.FPGS-VPS13C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FPGS-VPS13C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FPGS-VPS13C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FPGS-VPS13C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFPGS

GO:0006536

glutamate metabolic process

3619447

HgeneFPGS

GO:0006760

folic acid-containing compound metabolic process

3619447

HgeneFPGS

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

3619447


check buttonFusion gene breakpoints across FPGS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across VPS13C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8372-01AFPGSchr9

130566979

+VPS13Cchr15

62148608

-


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Fusion Gene ORF analysis for FPGS-VPS13C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000460181ENST00000249837FPGSchr9

130566979

+VPS13Cchr15

62148608

-
3UTR-3CDSENST00000460181ENST00000261517FPGSchr9

130566979

+VPS13Cchr15

62148608

-
3UTR-intronENST00000460181ENST00000395896FPGSchr9

130566979

+VPS13Cchr15

62148608

-
3UTR-intronENST00000460181ENST00000395898FPGSchr9

130566979

+VPS13Cchr15

62148608

-
3UTR-intronENST00000460181ENST00000558919FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373225ENST00000395896FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373225ENST00000395898FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373225ENST00000558919FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373245ENST00000395896FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373245ENST00000395898FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373245ENST00000558919FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373247ENST00000395896FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373247ENST00000395898FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000373247ENST00000558919FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000393706ENST00000395896FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000393706ENST00000395898FPGSchr9

130566979

+VPS13Cchr15

62148608

-
5CDS-intronENST00000393706ENST00000558919FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373225ENST00000249837FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373225ENST00000261517FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373245ENST00000249837FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373245ENST00000261517FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373247ENST00000249837FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000373247ENST00000261517FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000393706ENST00000249837FPGSchr9

130566979

+VPS13Cchr15

62148608

-
In-frameENST00000393706ENST00000261517FPGSchr9

130566979

+VPS13Cchr15

62148608

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373247FPGSchr9130566979+ENST00000249837VPS13Cchr1562148608-281443650745231
ENST00000373247FPGSchr9130566979+ENST00000261517VPS13Cchr1562148608-281043650745231
ENST00000373245FPGSchr9130566979+ENST00000249837VPS13Cchr1562148608-281443650745231
ENST00000373245FPGSchr9130566979+ENST00000261517VPS13Cchr1562148608-281043650745231
ENST00000393706FPGSchr9130566979+ENST00000249837VPS13Cchr1562148608-280742943738231
ENST00000393706FPGSchr9130566979+ENST00000261517VPS13Cchr1562148608-280342943738231
ENST00000373225FPGSchr9130566979+ENST00000249837VPS13Cchr1562148608-2823445209754181
ENST00000373225FPGSchr9130566979+ENST00000261517VPS13Cchr1562148608-2819445209754181

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373247ENST00000249837FPGSchr9130566979+VPS13Cchr1562148608-0.0003228190.9996772
ENST00000373247ENST00000261517FPGSchr9130566979+VPS13Cchr1562148608-0.0003209550.9996791
ENST00000373245ENST00000249837FPGSchr9130566979+VPS13Cchr1562148608-0.0003228190.9996772
ENST00000373245ENST00000261517FPGSchr9130566979+VPS13Cchr1562148608-0.0003209550.9996791
ENST00000393706ENST00000249837FPGSchr9130566979+VPS13Cchr1562148608-0.0003823350.9996177
ENST00000393706ENST00000261517FPGSchr9130566979+VPS13Cchr1562148608-0.0003809250.999619
ENST00000373225ENST00000249837FPGSchr9130566979+VPS13Cchr1562148608-0.0029247320.9970753
ENST00000373225ENST00000261517FPGSchr9130566979+VPS13Cchr1562148608-0.0029159270.9970841

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Fusion Genomic Features for FPGS-VPS13C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FPGS-VPS13C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130566979/chr15:62148608)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FPGS

Q05932

.
FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFPGSchr9:130566979chr15:62148608ENST00000373247+415106_109128588.0Nucleotide bindingATP
HgeneFPGSchr9:130566979chr15:62148608ENST00000393706+414106_109128562.0Nucleotide bindingATP
TgeneVPS13Cchr9:130566979chr15:62148608ENST00000395896082145_17903629.0Compositional biasLys-rich
TgeneVPS13Cchr9:130566979chr15:62148608ENST00000395898080145_17903586.0Compositional biasLys-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFPGSchr9:130566979chr15:62148608ENST00000373225+415106_10978538.0Nucleotide bindingATP
TgeneVPS13Cchr9:130566979chr15:62148608ENST000002498377983145_17936073711.0Compositional biasLys-rich
TgeneVPS13Cchr9:130566979chr15:62148608ENST000002615178185145_17936503754.0Compositional biasLys-rich


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Fusion Gene Sequence for FPGS-VPS13C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31263_31263_1_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373225_VPS13C_chr15_62148608_ENST00000249837_length(transcript)=2823nt_BP=445nt
TGGGGGTGGGGACAGGGACCAGGAAGTTGGGCCCGGGCCGCCGGGGCTGGGAATTCGGAGACTATAGCGTCCCCGCCCCGGGTTGGGAAG
TGGGAAGTGGCACAGGAGCTAGGATCCAGAAGCCCAGAGGCTCAGCGGTGCTTCTGGAGTTCCAGTGATCCCGGAGTCTGAACCGGCAGT
GAGAGTGGGGAAAGAGGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTG
ACCCTCAGACACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACG
TCACTGGGACGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAG
TGTTGTGTATAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCA
GTGAAAATGTGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACC
TGAAGGACACCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCAT
CAGTGAGACTTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTAT
AAGTCACTCTGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGT
TTTTTCACCTTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCT
TGAAGAAACGTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGC
CTTACTGAAGAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTT
GAGACCGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTC
TACTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGAT
GAGTTTCACCATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCAT
GAGCCACCACGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAA
CTGAGTTAACATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAA
AACACTGTTTTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAAC
CTTAAAATAGCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGAC
ACAATTATTATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCA
GAAATTGTTTCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACT
TACTAAGAAGAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTG
AGAATCAATTCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATA
TGTAAGTTTTTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGA
CACGCTTGGTTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAA
ATTTTACTAGTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTT
CAAAATTATTTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAG
GGATCATTATCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTT
CATATGAATCACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATC
TCCAGGGACAGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATA
AAACATTTGGCACATTGTTTACAGGTGTGAAAA

>31263_31263_1_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373225_VPS13C_chr15_62148608_ENST00000249837_length(amino acids)=181AA_BP=78
MLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEIL
GLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLP
S

--------------------------------------------------------------
>31263_31263_2_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373225_VPS13C_chr15_62148608_ENST00000261517_length(transcript)=2819nt_BP=445nt
TGGGGGTGGGGACAGGGACCAGGAAGTTGGGCCCGGGCCGCCGGGGCTGGGAATTCGGAGACTATAGCGTCCCCGCCCCGGGTTGGGAAG
TGGGAAGTGGCACAGGAGCTAGGATCCAGAAGCCCAGAGGCTCAGCGGTGCTTCTGGAGTTCCAGTGATCCCGGAGTCTGAACCGGCAGT
GAGAGTGGGGAAAGAGGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTG
ACCCTCAGACACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACG
TCACTGGGACGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAG
TGTTGTGTATAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCA
GTGAAAATGTGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACC
TGAAGGACACCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCAT
CAGTGAGACTTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTAT
AAGTCACTCTGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGT
TTTTTCACCTTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCT
TGAAGAAACGTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGC
CTTACTGAAGAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTT
GAGACCGAGTCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTC
TACTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGAT
GAGTTTCACCATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCAT
GAGCCACCACGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAA
CTGAGTTAACATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAA
AACACTGTTTTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAAC
CTTAAAATAGCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGAC
ACAATTATTATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCA
GAAATTGTTTCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACT
TACTAAGAAGAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTG
AGAATCAATTCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATA
TGTAAGTTTTTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGA
CACGCTTGGTTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAA
ATTTTACTAGTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTT
CAAAATTATTTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAG
GGATCATTATCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTT
CATATGAATCACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATC
TCCAGGGACAGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATA
AAACATTTGGCACATTGTTTACAGGTGTG

>31263_31263_2_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373225_VPS13C_chr15_62148608_ENST00000261517_length(amino acids)=181AA_BP=78
MLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEIL
GLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDSANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLP
S

--------------------------------------------------------------
>31263_31263_3_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373245_VPS13C_chr15_62148608_ENST00000249837_length(transcript)=2814nt_BP=436nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTA
TAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATG
TGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACA
CCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGAC
TTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTC
TGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACC
TTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAAC
GTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAA
GAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAG
TCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTC
AGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCAC
CATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCA
CGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAA
CATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTT
TTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATA
GCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATT
ATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTT
TCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAA
GAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAAT
TCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTT
TTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGG
TTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTA
GTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTAT
TTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTA
TCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAAT
CACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGAC
AGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTG
GCACATTGTTTACAGGTGTGAAAA

>31263_31263_3_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373245_VPS13C_chr15_62148608_ENST00000249837_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

--------------------------------------------------------------
>31263_31263_4_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373245_VPS13C_chr15_62148608_ENST00000261517_length(transcript)=2810nt_BP=436nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTA
TAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATG
TGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACA
CCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGAC
TTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTC
TGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACC
TTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAAC
GTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAA
GAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAG
TCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTC
AGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCAC
CATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCA
CGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAA
CATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTT
TTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATA
GCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATT
ATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTT
TCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAA
GAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAAT
TCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTT
TTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGG
TTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTA
GTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTAT
TTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTA
TCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAAT
CACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGAC
AGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTG
GCACATTGTTTACAGGTGTG

>31263_31263_4_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373245_VPS13C_chr15_62148608_ENST00000261517_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

--------------------------------------------------------------
>31263_31263_5_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373247_VPS13C_chr15_62148608_ENST00000249837_length(transcript)=2814nt_BP=436nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTA
TAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATG
TGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACA
CCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGAC
TTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTC
TGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACC
TTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAAC
GTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAA
GAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAG
TCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTC
AGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCAC
CATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCA
CGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAA
CATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTT
TTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATA
GCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATT
ATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTT
TCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAA
GAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAAT
TCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTT
TTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGG
TTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTA
GTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTAT
TTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTA
TCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAAT
CACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGAC
AGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTG
GCACATTGTTTACAGGTGTGAAAA

>31263_31263_5_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373247_VPS13C_chr15_62148608_ENST00000249837_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

--------------------------------------------------------------
>31263_31263_6_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373247_VPS13C_chr15_62148608_ENST00000261517_length(transcript)=2810nt_BP=436nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTA
TAAAGGAAGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATG
TGCTAAAAATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACA
CCGCCACAGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGAC
TTCTCAGACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTC
TGCTTTATCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACC
TTTTAGTTTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAAC
GTCACTTCAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAA
GAATAAGAAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAG
TCTTGCTCTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTC
AGCCTCCTGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCAC
CATGTTGGTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCA
CGGCCCGCCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAA
CATTCTTGGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTT
TTTCCCCCTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATA
GCTACACTCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATT
ATTTGCTGATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTT
TCTTACAGGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAA
GAATGAAAATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAAT
TCAGGACAGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTT
TTTGGTTGAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGG
TTTGCTCTATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTA
GTGTTACTTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTAT
TTTTTTCTGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTA
TCAGTAATTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAAT
CACAGCTGTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGAC
AGAAATAATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTG
GCACATTGTTTACAGGTGTG

>31263_31263_6_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000373247_VPS13C_chr15_62148608_ENST00000261517_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

--------------------------------------------------------------
>31263_31263_7_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000393706_VPS13C_chr15_62148608_ENST00000249837_length(transcript)=2807nt_BP=429nt
GTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCCTGGCAGC
GGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGGAGTACCA
GGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGACACAGTT
GGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGACGAAGGG
GAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTATAAAGGA
AGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATGTGCTAAA
AATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACACCGCCAC
AGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGACTTCTCAG
ACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTCTGCTTTA
TCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACCTTTTAGT
TTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAACGTCACTT
CAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAAGAATAAG
AAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAGTCTTGCT
CTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTCAGCCTCC
TGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCACCATGTTG
GTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGGCCCG
CCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAACATTCTT
GGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTTTTTCCCC
CTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATAGCTACAC
TCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATTATTTGCT
GATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTTTCTTACA
GGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAAGAATGAA
AATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAATTCAGGAC
AGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTTTTTGGTT
GAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGGTTTGCTC
TATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTAGTGTTAC
TTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTATTTTTTTC
TGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTATCAGTAA
TTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAATCACAGCT
GTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGACAGAAATA
ATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTGGCACATT
GTTTACAGGTGTGAAAA

>31263_31263_7_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000393706_VPS13C_chr15_62148608_ENST00000249837_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

--------------------------------------------------------------
>31263_31263_8_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000393706_VPS13C_chr15_62148608_ENST00000261517_length(transcript)=2803nt_BP=429nt
GTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCCTGGCAGC
GGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGGAGTACCA
GGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGACACAGTT
GGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGACGAAGGG
GAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGGCGAGTGTTGTGTATAAAGGA
AGTTGAAATCCTGGGCCTTATGTGTGTAGACTGGCAATGTCCATTTGAAGATTTTGTATTTCCTCCTAGTGTCAGTGAAAATGTGCTAAA
AATTTCAGTTAAGGAACAGGGTCTGTTCCACAAAAAAGACAGTGCCAATCAAGGCTGTGTTCGAAAAGTTTACCTGAAGGACACCGCCAC
AGCAGAGAGAGCATGTAATGCCATTGAGGATGCACAGTCAACGAGACAGCAGCAAAAATTGATGAAGCAGTCATCAGTGAGACTTCTCAG
ACCCCAATTGCCATCTTAATCACAGACCTCAGGGGCTCCAACAGGGAGAAAAAACAATCACTGGTCTTGTCTATAAGTCACTCTGCTTTA
TCTTGCTAAAGACAATTTTTCAAGCAATCCTTTAGTTTTAGTTTTCTGGAATAGCTAGTATTGGGTTTTCTAGTTTTTTCACCTTTTAGT
TTTTACTCTAATTTTGTAACCATGTATATGCTAGCAGTCCACTTCTACGCCACCACCCAAATGGGTCAGACCCTTGAAGAAACGTCACTT
CAAACTCAGAATGAAATTTTCATTAATATTAAAATTGTGAAGCAAAGGTCAATAGGCTTATATTTAATTAAAGCCTTACTGAAGAATAAG
AAATGAGCTTAGAATGACTAGTGTTCTTTGAAAGGTTTTTTTATTTTTGTTTTTTTGGGGTTTTTTTTTTTTTTGAGACCGAGTCTTGCT
CTGTCGCCCAGGCTGGAATGCAGTGGTGCGATCTTGGCTCACTGCAATCTCTGCCTCTCGGGTTCAAGCTGTTCTACTGCCTCAGCCTCC
TGAGTAGCTGGGATTACAGGTGTGTGCCACCACGCCTGGGTAATTTTTTTTTTTTTTGTATTTTTAGTAGAGATGAGTTTCACCATGTTG
GTCAGTCTAGTCTCGAACTCCTGACCTTGTGATCCGCATGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCACGGCCCG
CCAAAAGGCTTTAACCCATGAACAAATGTTGGATCCTGACATTTTGTTTAAGAGTGATTTGTTCAATAATTGAACTGAGTTAACATTCTT
GGTAAACCAGGTAATTGAATGAAGAAAGGTCACTAAAGGGAGAAATGACATGTTTTCTATTTTCTTTTCATGAAAACACTGTTTTTCCCC
CTAATAAAGCATATTTTACTTTGGTGCTTATTTTTCCTCCTTGCAGTCTAATAAAAAAATCTGGACAATCAAACCTTAAAATAGCTACAC
TCTGCCCTCTGTAATGTAGCATTCATAAAAATTTGGAAGTATTTACATCCTCTTTCAAGATGAGCTTATATGACACAATTATTATTTGCT
GATACATGAAAATACTGCACTTTAAGTTTCTCAAGACTCTGAAATATGTAAAATTCAATATTTTTATATTCCCAGAAATTGTTTCTTACA
GGTTGAAAGTCTTTTAAGGGCATCACAAATTAACATTTACTCCTAATGCACGCCTAGAATGTATTTTAAATACTTACTAAGAAGAATGAA
AATTCTTTGGTTGTTTTATATATAAATAAGGCATATATAATGACACTGTGTTCTGTGAGGGAGCAGGCCCTGTGAGAATCAATTCAGGAC
AGTATTTTTTTTTGTCCTTTCTCCATCCTTGATCAGAGATAAACTATTAAAACTTTAAAAAATACTCAAAAATATGTAAGTTTTTTGGTT
GAACCTTTAGATTTGCTCATAATGTTTAACATAACAACATTTATTTCAAATCACTGAATTCATGGAGATGTGGACACGCTTGGTTTGCTC
TATTTTTGTTTATGTGTGATAGTGGTTCTGTCATCATCATTCATGTTTTTTAAGGCCTGGTCATAAAACTTTAAATTTTACTAGTGTTAC
TTAATGTATATTCTAAAAAGAGAATGCAGTAACTAATGCCCTAAATGTTTGATCTCTGTTTGTCATTACTTTTTCAAAATTATTTTTTTC
TGTAAAGTATAATATATAAAACTTCTTGCTTAAATTGAATTTCTATATTAGTGGTTAATTGCAGTTTATTAAAGGGATCATTATCAGTAA
TTTCATAGCAACTGTTCTAGTGTTTTGTGTTTTTAAAACAGAATTAGGAATTTGAGATATCTGATTATATTTTTCATATGAATCACAGCT
GTTGACAATGTCCCATATATTTAAGAAATTATATCATACTGATACTATTTGTAACATTTTGATTTGATTTAATCTCCAGGGACAGAAATA
ATTCATTGGTAAAGTGTAATAATGCGTTTTTTAAAAATGCTTTGAGAGGTAATTACTTGCATATGAGAGAAATAAAACATTTGGCACATT
GTTTACAGGTGTG

>31263_31263_8_FPGS-VPS13C_FPGS_chr9_130566979_ENST00000393706_VPS13C_chr15_62148608_ENST00000261517_length(amino acids)=231AA_BP=128
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFRRVLCIKEVEILGLMCVDWQCPFEDFVFPPSVSENVLKISVKEQGLFHKKDS
ANQGCVRKVYLKDTATAERACNAIEDAQSTRQQQKLMKQSSVRLLRPQLPS

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Fusion Gene PPI Analysis for FPGS-VPS13C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FPGS-VPS13C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFPGSQ05932DB00293RaltitrexedAntagonistSmall moleculeApproved|Investigational
HgeneFPGSQ05932DB00142Glutamic acidSmall moleculeApproved|Nutraceutical

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Related Diseases for FPGS-VPS13C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFPGSC0003873Rheumatoid Arthritis1CTD_human
HgeneFPGSC0009402Colorectal Carcinoma1CTD_human
HgeneFPGSC0009404Colorectal Neoplasms1CTD_human
HgeneFPGSC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneFPGSC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneFPGSC0024302Reticulosarcoma1CTD_human
HgeneFPGSC0024304Lymphoma, Mixed-Cell1CTD_human
HgeneFPGSC0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneFPGSC0024306Lymphoma, Undifferentiated1CTD_human
HgeneFPGSC0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneFPGSC0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneFPGSC0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneFPGSC0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneFPGSC0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneFPGSC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneFPGSC3714542Lymphoma, Diffuse1CTD_human
HgeneFPGSC4721532Lymphoma, Non-Hodgkin, Familial1CTD_human
TgeneC4225186PARKINSON DISEASE 23, AUTOSOMAL RECESSIVE EARLY-ONSET2CTD_human;GENOMICS_ENGLAND;UNIPROT