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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FPGS-GARNL3 (FusionGDB2 ID:HG2356TG84253)

Fusion Gene Summary for FPGS-GARNL3

check button Fusion gene summary
Fusion gene informationFusion gene name: FPGS-GARNL3
Fusion gene ID: hg2356tg84253
HgeneTgene
Gene symbol

FPGS

GARNL3

Gene ID

2356

84253

Gene namefolylpolyglutamate synthaseGTPase activating Rap/RanGAP domain like 3
Synonyms-bA356B19.1
Cytomap('FPGS')('GARNL3')

9q34.11

9q33.3

Type of geneprotein-codingprotein-coding
Descriptionfolylpolyglutamate synthase, mitochondrialfolylpoly-gamma-glutamate synthetasetetrahydrofolate synthasetetrahydrofolylpolyglutamate synthaseGTPase-activating Rap/Ran-GAP domain-like protein 3GTPase activating RANGAP domain-like 3
Modification date2020031320200313
UniProtAcc

Q05932

Q5VVW2

Ensembl transtripts involved in fusion geneENST00000373245, ENST00000460181, 
ENST00000373225, ENST00000373247, 
ENST00000393706, 
Fusion gene scores* DoF score6 X 6 X 5=1808 X 10 X 8=640
# samples 811
** MAII scorelog2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/640*10)=-2.5405683813627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FPGS [Title/Abstract] AND GARNL3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFPGS(130575602)-GARNL3(130145717), # samples:2
Anticipated loss of major functional domain due to fusion event.FPGS-GARNL3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FPGS-GARNL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FPGS-GARNL3 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
FPGS-GARNL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFPGS

GO:0006536

glutamate metabolic process

3619447

HgeneFPGS

GO:0006760

folic acid-containing compound metabolic process

3619447

HgeneFPGS

GO:0046901

tetrahydrofolylpolyglutamate biosynthetic process

3619447


check buttonFusion gene breakpoints across FPGS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GARNL3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A1Y7-01AFPGSchr9

130575602

+GARNL3chr9

130145717

+


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Fusion Gene ORF analysis for FPGS-GARNL3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000373245ENST00000314904FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3CDSENST00000373245ENST00000373387FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3CDSENST00000373245ENST00000435213FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3CDSENST00000460181ENST00000314904FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3CDSENST00000460181ENST00000373387FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3CDSENST00000460181ENST00000435213FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3UTRENST00000373245ENST00000496711FPGSchr9

130575602

+GARNL3chr9

130145717

+
3UTR-3UTRENST00000460181ENST00000496711FPGSchr9

130575602

+GARNL3chr9

130145717

+
5CDS-3UTRENST00000373225ENST00000496711FPGSchr9

130575602

+GARNL3chr9

130145717

+
5CDS-3UTRENST00000373247ENST00000496711FPGSchr9

130575602

+GARNL3chr9

130145717

+
5CDS-3UTRENST00000393706ENST00000496711FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000373225ENST00000314904FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000373225ENST00000373387FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000373225ENST00000435213FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000393706ENST00000314904FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000393706ENST00000373387FPGSchr9

130575602

+GARNL3chr9

130145717

+
Frame-shiftENST00000393706ENST00000435213FPGSchr9

130575602

+GARNL3chr9

130145717

+
In-frameENST00000373247ENST00000314904FPGSchr9

130575602

+GARNL3chr9

130145717

+
In-frameENST00000373247ENST00000373387FPGSchr9

130575602

+GARNL3chr9

130145717

+
In-frameENST00000373247ENST00000435213FPGSchr9

130575602

+GARNL3chr9

130145717

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373247FPGSchr9130575602+ENST00000435213GARNL3chr9130145717+31782145501684544
ENST00000373247FPGSchr9130575602+ENST00000314904GARNL3chr9130145717+31802145501684544
ENST00000373247FPGSchr9130575602+ENST00000373387GARNL3chr9130145717+34322145501684544

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373247ENST00000435213FPGSchr9130575602+GARNL3chr9130145717+0.0560834150.94391656
ENST00000373247ENST00000314904FPGSchr9130575602+GARNL3chr9130145717+0.0432789660.95672107
ENST00000373247ENST00000373387FPGSchr9130575602+GARNL3chr9130145717+0.0337204640.96627957

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Fusion Genomic Features for FPGS-GARNL3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FPGS-GARNL3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:130575602/chr9:130145717)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FPGS

Q05932

GARNL3

Q5VVW2

FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFPGSchr9:130575602chr9:130145717ENST00000373225+115106_1090538.0Nucleotide bindingATP
HgeneFPGSchr9:130575602chr9:130145717ENST00000373247+115106_1090588.0Nucleotide bindingATP
HgeneFPGSchr9:130575602chr9:130145717ENST00000393706+114106_1090562.0Nucleotide bindingATP
TgeneGARNL3chr9:130575602chr9:130145717ENST000003149042127191_407720811.6666666666666DomainRap-GAP
TgeneGARNL3chr9:130575602chr9:130145717ENST000003149042127489_800720811.6666666666666DomainCNH
TgeneGARNL3chr9:130575602chr9:130145717ENST000003733872128191_4077201014.0DomainRap-GAP
TgeneGARNL3chr9:130575602chr9:130145717ENST000003733872128489_8007201014.0DomainCNH


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Fusion Gene Sequence for FPGS-GARNL3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>31261_31261_1_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000314904_length(transcript)=3180nt_BP=2145nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGCTCTCCCCACCTGG
TGCAGGTTCGGGAGCGGATCCGCATCAATGGGCAGCCCATCAGTCCTGAGCTCTTCACCAAGTACTTCTGGCGCCTCTACCACCGGCTGG
AGGAGACCAAGGATGGCAGCTGTGTCTCCATGCCCCCCTACTTCCGCTTCCTGACACTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGG
TGGACCTGGCAGTGGTGGAGGTGGGCATTGGCGGGGCTTATGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGCGGAGTCTCCTCTC
TTGGCATCGACCACACCAGCCTCCTGGGGGATACGGTGGAGAAGATCGCATGGCAGAAAGGGGGCATCTTTAAGCAAGGTGTCCCTGCCT
TCACTGTGCTCCAACCTGAAGGTCCCCTGGCAGTGCTGAGGGACCGAGCCCAGCAGATCTCATGTCCTCTATACCTGTGTCCGATGCTGG
AGGCCCTCGAGGAAGGGGGGCCGCCGCTGACCCTGGGCCTGGAGGGGGAGCACCAGCGGTCCAACGCCGCCTTGGCCTTGCAGCTGGCCC
ACTGCTGGCTGCAGCGGCAGGACCGCCATGGTGCTGGGGAGCCAAAGGCATCCAGGCCAGGGCTCCTGTGGCAGCTGCCCCTGGCACCTG
TGTTCCAGCCCACATCCCACATGCGGCTCGGGCTTCGGAACACGGAGTGGCCGGGCCGGACGCAGGTGCTGCGGCGCGGGCCCCTCACCT
GGTACCTGGACGGTGCGCACACCGCCAGCAGCGCGCAGGCCTGCGTGCGCTGGTTCCGCCAGGCGCTGCAGGGCCGCGAGAGGCCGAGCG
GTGGCCCCGAGGTTCGAGTCTTGCTCTTCAATGCTACCGGGGACCGGGACCCGGCGGCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTG
ACTATGCCGTCTTCTGCCCTAACCTGACAGAGGTGTCATCCACAGGCAACGCAGGTGGGTCCGCATCCCTGCTTCTGGCGCCCCACCCAC
CCCACACCTGCAGTGCCAGCTCCCTCGTCTTCAGCTGCATTTCACATGCCTTGCAATGGATCAGCCAAGGCCGAGACCCCATCTTCCAGC
CACCTAGTCCCCCAAAGGGCCTCCTCACCCACCCTGTGGCTCACAGTGGGGCCAGCATACTCCGTGAGGCTGCTGCCATCCATGTGCTAG
TCACTGGCAGCCTGCACCTGGTGGGTGGTGTCCTGAAGCTGCTGGAGCCCGCACTGTCCCAGTAGCCAAGGCCCGGGGTTGGAGGTGGGA
GCTTCCCACACCTGCCTGCGTTCTCCCCATGAACTTACATACTAGGTGCCTTTTGTTTTTGGCTTTCCTGGTTCTGTCTAGACTGGCCTA
GGGGCCAGGGCTTTGGGATGGGAGGCCGGGAGAGGATGTCTTTTTTAAGGCTCTGTGCCTTGGTCTCTCCTTCCTCTTGGCTGAGATAGC
AGAGGGGCTCCCCGGGTCTCTCACTGTTGCAGTGGCCTGGCCGTTCAGCCTGTCTCCCCCAACACCCCGCCTGCCTCCTGGCTCAGGCCC
AGCTTATTGTGTGCGCTGCCTGGCCAGGCCCTGGGTCTTGCCATGTGCTGGGTGGTAGATTTCCTCCTCCCAGTGCCTTCTGGGAAGGGA
GAGGGCCTCTGCCTGGGACACTGCGGGACAGAGGGTGGCTGGAGTGAATTAAAGCCTTTGTTTTTTAAAGAAATGACAGTTGCATCTATA
AAAAGGTTTGCCCCTTTAATGGTGGCTCTTTTTTGGTTCAACCTTCTGCGTCAGATTTCCAGTTCTGTTGGAACCAGGCTCCCTATGCAA
TTGTCTGTGCTTTCCCGTATCTCCTGGCCTTCACCACCGACTCCATGGAGATCCGCCTGGTGGTGAACGGGAACCTGGTCCACACTGCAG
TCGTGCCGCAGCTGCAGCTGGTGGCCTCCAGGGTGAAATTCAATCAAAAAATCTGTACAAGATTCCACTTAGAAACCTCGTGGGCAGAAG
CATCGAACGACCTCTGAAGTCACCCTTAGTCTCCAAGGTCATCACCCCACCCACTCCCATCAGTGTGGGCCTTGCTGCCATTCCAGTCAC
GCACTCCTTGTCCCTGTCTCGCATGGAGATCAAAGAAATAGCAAGCAGGACCCGCAGGGAACTACTGGGCCTCTCGGATGAAGGTGGACC
CAAGTCAGAAGGAGCGCCAAAGGCCAAATCAAAACCCCGGAAGCGGTTAGAAGAAAGCCAAGGAGGCCCCAAGCCAGGGGCAGTGAGGTC
ATCTAGCAGTGACAGGATCCCATCAGGCTCCTTGGAAAGTGCTTCTACTTCCGAAGCCAACCCTGAGGGGCACTCAGCCAGCTCTGACCA
GGACCCTGTGGCAGACAGAGAGGGCAGCCCGGTCTCCGGCAGCAGCCCCTTCCAGCTCACGGCTTTCTCCGATGAAGACATTATAGACTT
GAAGTAACAGAGTTGAATCTCATTTGCCATCTTTAGTTTTCTTATGGAGGTTTATACTCTTTAAACAGTTCTGATGTAATTTCTCAACAA
AATGTGGCTTTTAGCCTGTCAGTGATCTATTGGACCAAACCTTCTGCACACTCGGCCAGTTCCCTCTCCAATGTCCGGTGCCATCTTTCC
TGACCTTTGTTTCTTTCTGTTCAGGAACCATCAGTCCCCTTGTAATAAAGGTGGTAGATTTCATTGAGGTTTTAGATTGAAACTTTGAAT

>31261_31261_1_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000314904_length(amino acids)=544AA_BP=
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRA
QQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGN
AGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEP

--------------------------------------------------------------
>31261_31261_2_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000373387_length(transcript)=3432nt_BP=2145nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGCTCTCCCCACCTGG
TGCAGGTTCGGGAGCGGATCCGCATCAATGGGCAGCCCATCAGTCCTGAGCTCTTCACCAAGTACTTCTGGCGCCTCTACCACCGGCTGG
AGGAGACCAAGGATGGCAGCTGTGTCTCCATGCCCCCCTACTTCCGCTTCCTGACACTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGG
TGGACCTGGCAGTGGTGGAGGTGGGCATTGGCGGGGCTTATGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGCGGAGTCTCCTCTC
TTGGCATCGACCACACCAGCCTCCTGGGGGATACGGTGGAGAAGATCGCATGGCAGAAAGGGGGCATCTTTAAGCAAGGTGTCCCTGCCT
TCACTGTGCTCCAACCTGAAGGTCCCCTGGCAGTGCTGAGGGACCGAGCCCAGCAGATCTCATGTCCTCTATACCTGTGTCCGATGCTGG
AGGCCCTCGAGGAAGGGGGGCCGCCGCTGACCCTGGGCCTGGAGGGGGAGCACCAGCGGTCCAACGCCGCCTTGGCCTTGCAGCTGGCCC
ACTGCTGGCTGCAGCGGCAGGACCGCCATGGTGCTGGGGAGCCAAAGGCATCCAGGCCAGGGCTCCTGTGGCAGCTGCCCCTGGCACCTG
TGTTCCAGCCCACATCCCACATGCGGCTCGGGCTTCGGAACACGGAGTGGCCGGGCCGGACGCAGGTGCTGCGGCGCGGGCCCCTCACCT
GGTACCTGGACGGTGCGCACACCGCCAGCAGCGCGCAGGCCTGCGTGCGCTGGTTCCGCCAGGCGCTGCAGGGCCGCGAGAGGCCGAGCG
GTGGCCCCGAGGTTCGAGTCTTGCTCTTCAATGCTACCGGGGACCGGGACCCGGCGGCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTG
ACTATGCCGTCTTCTGCCCTAACCTGACAGAGGTGTCATCCACAGGCAACGCAGGTGGGTCCGCATCCCTGCTTCTGGCGCCCCACCCAC
CCCACACCTGCAGTGCCAGCTCCCTCGTCTTCAGCTGCATTTCACATGCCTTGCAATGGATCAGCCAAGGCCGAGACCCCATCTTCCAGC
CACCTAGTCCCCCAAAGGGCCTCCTCACCCACCCTGTGGCTCACAGTGGGGCCAGCATACTCCGTGAGGCTGCTGCCATCCATGTGCTAG
TCACTGGCAGCCTGCACCTGGTGGGTGGTGTCCTGAAGCTGCTGGAGCCCGCACTGTCCCAGTAGCCAAGGCCCGGGGTTGGAGGTGGGA
GCTTCCCACACCTGCCTGCGTTCTCCCCATGAACTTACATACTAGGTGCCTTTTGTTTTTGGCTTTCCTGGTTCTGTCTAGACTGGCCTA
GGGGCCAGGGCTTTGGGATGGGAGGCCGGGAGAGGATGTCTTTTTTAAGGCTCTGTGCCTTGGTCTCTCCTTCCTCTTGGCTGAGATAGC
AGAGGGGCTCCCCGGGTCTCTCACTGTTGCAGTGGCCTGGCCGTTCAGCCTGTCTCCCCCAACACCCCGCCTGCCTCCTGGCTCAGGCCC
AGCTTATTGTGTGCGCTGCCTGGCCAGGCCCTGGGTCTTGCCATGTGCTGGGTGGTAGATTTCCTCCTCCCAGTGCCTTCTGGGAAGGGA
GAGGGCCTCTGCCTGGGACACTGCGGGACAGAGGGTGGCTGGAGTGAATTAAAGCCTTTGTTTTTTAAAGAAATGACAGTTGCATCTATA
AAAAGGTTTGCCCCTTTAATGGTGGCTCTTTTTTGGTTCAACCTTCTGCGTCAGATTTCCAGTTCTGTTGGAACCAGGCTCCCTATGCAA
TTGTCTGTGCTTTCCCGTATCTCCTGGCCTTCACCACCGACTCCATGGAGATCCGCCTGGTGGTGAACGGGAACCTGGTCCACACTGCAG
TCGTGCCGCAGCTGCAGCTGGTGGCCTCCAGGTCGGATATATACTTCACAGCAACTGCAGCTGTGAATGAGGTCTCATCTGGAGGCAGCT
CCAAGGGGGCCAGTGCCCGAAATTCTCCTCAGACACCCCCGGGCCGAGATACTCCAGTATTTCCTTCTTCCCTGGGGGAAGGTGAAATTC
AATCAAAAAATCTGTACAAGATTCCACTTAGAAACCTCGTGGGCAGAAGCATCGAACGACCTCTGAAGTCACCCTTAGTCTCCAAGGTCA
TCACCCCACCCACTCCCATCAGTGTGGGCCTTGCTGCCATTCCAGTCACGCACTCCTTGTCCCTGTCTCGCATGGAGATCAAAGAAATAG
CAAGCAGGACCCGCAGGGAACTACTGGGCCTCTCGGATGAAGGTGGACCCAAGTCAGAAGGAGCGCCAAAGGCCAAATCAAAACCCCGGA
AGCGGTTAGAAGAAAGCCAAGGAGGCCCCAAGCCAGGGGCAGTGAGGTCATCTAGCAGTGACAGGATCCCATCAGGCTCCTTGGAAAGTG
CTTCTACTTCCGAAGCCAACCCTGAGGGGCACTCAGCCAGCTCTGACCAGGACCCTGTGGCAGACAGAGAGGGCAGCCCGGTCTCCGGCA
GCAGCCCCTTCCAGCTCACGGCTTTCTCCGATGAAGACATTATAGACTTGAAGTAACAGAGTTGAATCTCATTTGCCATCTTTAGTTTTC
TTATGGAGGTTTATACTCTTTAAACAGTTCTGATGTAATTTCTCAACAAAATGTGGCTTTTAGCCTGTCAGTGATCTATTGGACCAAACC
TTCTGCACACTCGGCCAGTTCCCTCTCCAATGTCCGGTGCCATCTTTCCTGACCTTTGTTTCTTTCTGTTCAGGAACCATCAGTCCCCTT
GTAATAAAGGTGGTAGATTTCATTGAGGTTTTAGATTGAAACTTTGAATAAATCAAAAATACTCATTCTTATTTACTGCAACCTTCTCAT
ATTTTATATACTTAGATGGAAAATTATTTTTTCATTACAGTTTTGATTTATGTCACATAATGTGTTTCTTTTATAAAGAAAAGTCGTTGC

>31261_31261_2_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000373387_length(amino acids)=544AA_BP=
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRA
QQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGN
AGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEP

--------------------------------------------------------------
>31261_31261_3_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000435213_length(transcript)=3178nt_BP=2145nt
GCGGGGCGTCTCCCGCCCGGGCCTAGAGCGCTGCCGGGGGCGCCGGGACTATGTCGCGGGCGCGGAGCCACCTGCGCGCCGCTCTATTCC
TGGCAGCGGCGTCTGCGCGCGGCATAACGACCCAGGTCGCGGCGCGGCGGGGCTTGAGCGCGTGGCCGGTGCCGCAGGAGCCGAGCATGG
AGTACCAGGATGCCGTGCGCATGCTCAATACCCTGCAGACCAATGCCGGCTACCTGGAGCAGGTGAAGCGCCAGCGGGGTGACCCTCAGA
CACAGTTGGAAGCCATGGAACTGTACCTGGCACGGAGTGGGCTGCAGGTGGAGGACTTGGACCGGCTGAACATCATCCACGTCACTGGGA
CGAAGGGGAAGGGCTCCACCTGTGCCTTCACGGAATGTATCCTCCGAAGCTATGGCCTGAAGACGGGATTCTTTAGCTCTCCCCACCTGG
TGCAGGTTCGGGAGCGGATCCGCATCAATGGGCAGCCCATCAGTCCTGAGCTCTTCACCAAGTACTTCTGGCGCCTCTACCACCGGCTGG
AGGAGACCAAGGATGGCAGCTGTGTCTCCATGCCCCCCTACTTCCGCTTCCTGACACTCATGGCCTTCCACGTCTTCCTCCAAGAGAAGG
TGGACCTGGCAGTGGTGGAGGTGGGCATTGGCGGGGCTTATGACTGCACCAACATCATCAGGAAGCCTGTGGTGTGCGGAGTCTCCTCTC
TTGGCATCGACCACACCAGCCTCCTGGGGGATACGGTGGAGAAGATCGCATGGCAGAAAGGGGGCATCTTTAAGCAAGGTGTCCCTGCCT
TCACTGTGCTCCAACCTGAAGGTCCCCTGGCAGTGCTGAGGGACCGAGCCCAGCAGATCTCATGTCCTCTATACCTGTGTCCGATGCTGG
AGGCCCTCGAGGAAGGGGGGCCGCCGCTGACCCTGGGCCTGGAGGGGGAGCACCAGCGGTCCAACGCCGCCTTGGCCTTGCAGCTGGCCC
ACTGCTGGCTGCAGCGGCAGGACCGCCATGGTGCTGGGGAGCCAAAGGCATCCAGGCCAGGGCTCCTGTGGCAGCTGCCCCTGGCACCTG
TGTTCCAGCCCACATCCCACATGCGGCTCGGGCTTCGGAACACGGAGTGGCCGGGCCGGACGCAGGTGCTGCGGCGCGGGCCCCTCACCT
GGTACCTGGACGGTGCGCACACCGCCAGCAGCGCGCAGGCCTGCGTGCGCTGGTTCCGCCAGGCGCTGCAGGGCCGCGAGAGGCCGAGCG
GTGGCCCCGAGGTTCGAGTCTTGCTCTTCAATGCTACCGGGGACCGGGACCCGGCGGCCCTGCTGAAGCTGCTGCAGCCCTGCCAGTTTG
ACTATGCCGTCTTCTGCCCTAACCTGACAGAGGTGTCATCCACAGGCAACGCAGGTGGGTCCGCATCCCTGCTTCTGGCGCCCCACCCAC
CCCACACCTGCAGTGCCAGCTCCCTCGTCTTCAGCTGCATTTCACATGCCTTGCAATGGATCAGCCAAGGCCGAGACCCCATCTTCCAGC
CACCTAGTCCCCCAAAGGGCCTCCTCACCCACCCTGTGGCTCACAGTGGGGCCAGCATACTCCGTGAGGCTGCTGCCATCCATGTGCTAG
TCACTGGCAGCCTGCACCTGGTGGGTGGTGTCCTGAAGCTGCTGGAGCCCGCACTGTCCCAGTAGCCAAGGCCCGGGGTTGGAGGTGGGA
GCTTCCCACACCTGCCTGCGTTCTCCCCATGAACTTACATACTAGGTGCCTTTTGTTTTTGGCTTTCCTGGTTCTGTCTAGACTGGCCTA
GGGGCCAGGGCTTTGGGATGGGAGGCCGGGAGAGGATGTCTTTTTTAAGGCTCTGTGCCTTGGTCTCTCCTTCCTCTTGGCTGAGATAGC
AGAGGGGCTCCCCGGGTCTCTCACTGTTGCAGTGGCCTGGCCGTTCAGCCTGTCTCCCCCAACACCCCGCCTGCCTCCTGGCTCAGGCCC
AGCTTATTGTGTGCGCTGCCTGGCCAGGCCCTGGGTCTTGCCATGTGCTGGGTGGTAGATTTCCTCCTCCCAGTGCCTTCTGGGAAGGGA
GAGGGCCTCTGCCTGGGACACTGCGGGACAGAGGGTGGCTGGAGTGAATTAAAGCCTTTGTTTTTTAAAGAAATGACAGTTGCATCTATA
AAAAGGTTTGCCCCTTTAATGGTGGCTCTTTTTTGGTTCAACCTTCTGCGTCAGATTTCCAGTTCTGTTGGAACCAGGCTCCCTATGCAA
TTGTCTGTGCTTTCCCGTATCTCCTGGCCTTCACCACCGACTCCATGGAGATCCGCCTGGTGGTGAACGGGAACCTGGTCCACACTGCAG
TCGTGCCGCAGCTGCAGCTGGTGGCCTCCAGGTCGGATATATACTTCACAGCAACTGCAGCTGTGAATGAGGTCTCATCTGGAGGCAGCT
CCAAGGGGGCCAGTGCCCGAAATTCTCCTCAGACACCCCCGGGCCGAGATACTCCAGTATTTCCTTCTTCCCTGGGGGAAGGTGAAATTC
AATCAAAAAATCTGTACAAGATTCCACTTAGAAACCTCGTGGGCAGAAGCATCGAACGACCTCTGAAGTCACCCTTAGTCTCCAAGGTCA
TCACCCCACCCACTCCCATCAGTGTGGGCCTTGCTGCCATTCCAGTCACGCACTCCTTGTCCCTGTCTCGCATGGAGATCAAAGAAATAG
CAAGCAGGACCCGCAGGGAACTACTGGGCCTCTCGGATGAAGGTGGACCCAAGTCAGAAGGAGCGCCAAAGGCCAAATCAAAACCCCGGA
AGCGGTTAGAAGAAAGCCAAGGAGGCCCCAAGCCAGGGGCAGTGAGGTCATCTAGCAGTGACAGGATCCCATCAGGCTCCTTGGAAAGTG
CTTCTACTTCCGAAGCCAACCCTGAGGGGCACTCAGCCAGCTCTGACCAGGACCCTGTGGCAGACAGAGAGGGCAGCCCGGTCTCCGGCA
GCAGCCCCTTCCAGCTCACGGCTTTCTCCGATGAAGACATTATAGACTTGAAGTAACAGAGTTGAATCTCATTTGCCATCTTTAGTTTTC
TTATGGAGGTTTATACTCTTTAAACAGTTCTGATGTAATTTCTCAACAAAATGTGGCTTTTAGCCTGTCAGTGATCTATTGGACCAAACC

>31261_31261_3_FPGS-GARNL3_FPGS_chr9_130575602_ENST00000373247_GARNL3_chr9_130145717_ENST00000435213_length(amino acids)=544AA_BP=
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQV
EDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRA
QQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGN
AGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEP

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Fusion Gene PPI Analysis for FPGS-GARNL3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FPGS-GARNL3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneFPGSQ05932DB00293RaltitrexedAntagonistSmall moleculeApproved|Investigational
HgeneFPGSQ05932DB00142Glutamic acidSmall moleculeApproved|Nutraceutical

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Related Diseases for FPGS-GARNL3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFPGSC0003873Rheumatoid Arthritis1CTD_human
HgeneFPGSC0009402Colorectal Carcinoma1CTD_human
HgeneFPGSC0009404Colorectal Neoplasms1CTD_human
HgeneFPGSC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
HgeneFPGSC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
HgeneFPGSC0024302Reticulosarcoma1CTD_human
HgeneFPGSC0024304Lymphoma, Mixed-Cell1CTD_human
HgeneFPGSC0024305Lymphoma, Non-Hodgkin1CTD_human
HgeneFPGSC0024306Lymphoma, Undifferentiated1CTD_human
HgeneFPGSC0079740High Grade Lymphoma (neoplasm)1CTD_human
HgeneFPGSC0079741Lymphoma, Intermediate-Grade1CTD_human
HgeneFPGSC0079747Low Grade Lymphoma (neoplasm)1CTD_human
HgeneFPGSC0079757Diffuse Mixed-Cell Lymphoma1CTD_human
HgeneFPGSC0079770Lymphoma, Small Noncleaved-Cell1CTD_human
HgeneFPGSC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
HgeneFPGSC3714542Lymphoma, Diffuse1CTD_human
HgeneFPGSC4721532Lymphoma, Non-Hodgkin, Familial1CTD_human