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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOL2-HSPH1 (FusionGDB2 ID:HG23780TG10808)

Fusion Gene Summary for APOL2-HSPH1

check button Fusion gene summary
Fusion gene informationFusion gene name: APOL2-HSPH1
Fusion gene ID: hg23780tg10808
HgeneTgene
Gene symbol

APOL2

HSPH1

Gene ID

23780

10808

Gene nameapolipoprotein L2heat shock protein family H (Hsp110) member 1
SynonymsAPOL-II|APOL3HSP105|HSP105A|HSP105B|NY-CO-25
Cytomap('APOL2')('HSPH1')

22q12.3

13q12.3

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein L2apolipoprotein L, 2apolipoprotein L-IIheat shock protein 105 kDaantigen NY-CO-25heat shock 105kDa/110kDa protein 1
Modification date2020031320200313
UniProtAcc

Q9BQE5

.
Ensembl transtripts involved in fusion geneENST00000451256, ENST00000249066, 
ENST00000358502, ENST00000476579, 
Fusion gene scores* DoF score7 X 4 X 7=19610 X 10 X 4=400
# samples 711
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOL2 [Title/Abstract] AND HSPH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOL2(36635487)-HSPH1(31729791), # samples:1
Anticipated loss of major functional domain due to fusion event.APOL2-HSPH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOL2-HSPH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across APOL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HSPH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-5818-01AAPOL2chr22

36635487

-HSPH1chr13

31729791

-


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Fusion Gene ORF analysis for APOL2-HSPH1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000451256ENST00000429785APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000249066ENST00000320027APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000249066ENST00000380405APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000249066ENST00000380406APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000249066ENST00000445273APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000358502ENST00000320027APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000358502ENST00000380405APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000358502ENST00000380406APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-3CDSENST00000358502ENST00000445273APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-5UTRENST00000249066ENST00000429785APOL2chr22

36635487

-HSPH1chr13

31729791

-
5UTR-5UTRENST00000358502ENST00000429785APOL2chr22

36635487

-HSPH1chr13

31729791

-
In-frameENST00000451256ENST00000320027APOL2chr22

36635487

-HSPH1chr13

31729791

-
In-frameENST00000451256ENST00000380405APOL2chr22

36635487

-HSPH1chr13

31729791

-
In-frameENST00000451256ENST00000380406APOL2chr22

36635487

-HSPH1chr13

31729791

-
In-frameENST00000451256ENST00000445273APOL2chr22

36635487

-HSPH1chr13

31729791

-
intron-3CDSENST00000476579ENST00000320027APOL2chr22

36635487

-HSPH1chr13

31729791

-
intron-3CDSENST00000476579ENST00000380405APOL2chr22

36635487

-HSPH1chr13

31729791

-
intron-3CDSENST00000476579ENST00000380406APOL2chr22

36635487

-HSPH1chr13

31729791

-
intron-3CDSENST00000476579ENST00000445273APOL2chr22

36635487

-HSPH1chr13

31729791

-
intron-5UTRENST00000476579ENST00000429785APOL2chr22

36635487

-HSPH1chr13

31729791

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000451256APOL2chr2236635487-ENST00000380406HSPH1chr1331729791-30668792375788
ENST00000451256APOL2chr2236635487-ENST00000380405HSPH1chr1331729791-30578792366785
ENST00000451256APOL2chr2236635487-ENST00000320027HSPH1chr1331729791-31898792498829
ENST00000451256APOL2chr2236635487-ENST00000445273HSPH1chr1331729791-28968792498829

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000451256ENST00000380406APOL2chr2236635487-HSPH1chr1331729791-0.0004348460.9995652
ENST00000451256ENST00000380405APOL2chr2236635487-HSPH1chr1331729791-0.0002560540.999744
ENST00000451256ENST00000320027APOL2chr2236635487-HSPH1chr1331729791-0.0003467940.9996532
ENST00000451256ENST00000445273APOL2chr2236635487-HSPH1chr1331729791-0.0004559540.99954396

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Fusion Genomic Features for APOL2-HSPH1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APOL2-HSPH1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:36635487/chr13:31729791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOL2

Q9BQE5

.
FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPOL2chr22:36635487chr13:31729791ENST00000249066-26157_1620338.0Compositional biasNote=Poly-Ala
HgeneAPOL2chr22:36635487chr13:31729791ENST00000358502-15157_1620338.0Compositional biasNote=Poly-Ala


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Fusion Gene Sequence for APOL2-HSPH1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5611_5611_1_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000320027_length(transcript)=3189nt_BP=87nt
ATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGCAA
ATCACTCATGCAAACAATACGGTGTCTAACTTCAAAAGATTTCATGGCCGAGCATTCAATGACCCCTTCATTCAAAAGGAGAAGGAAAAC
TTGAGTTACGATTTGGTTCCATTGAAAAATGGTGGAGTTGGAATAAAGGTAATGTACATGGGTGAAGAACATCTATTTAGTGTGGAGCAG
ATAACAGCCATGTTGTTGACTAAGCTGAAGGAAACTGCTGAAAACAGCCTCAAGAAACCAGTAACAGATTGTGTTATTTCAGTCCCCTCC
TTCTTTACAGATGCTGAGAGGCGATCTGTGTTAGATGCTGCACAGATTGTTGGCCTAAACTGTTTAAGACTTATGAATGACATGACAGCT
GTTGCTTTGAATTACGGAATTTATAAGCAGGATCTCCCAAGCCTGGATGAGAAACCTCGGATAGTGGTTTTTGTTGATATGGGACATTCA
GCTTTTCAAGTGTCTGCTTGTGCTTTTAACAAGGGAAAATTGAAGGTACTGGGAACAGCTTTTGATCCTTTCTTAGGAGGAAAAAACTTC
GATGAAAAGTTAGTGGAACATTTTTGTGCAGAATTTAAAACTAAGTACAAGTTGGATGCAAAATCCAAAATACGAGCACTCCTACGTCTG
TATCAGGAATGTGAAAAACTGAAAAAGCTAATGAGCTCTAACAGCACAGACCTTCCACTGAATATCGAATGCTTTATGAATGATAAAGAT
GTTTCCGGAAAGATGAACAGGTCACAATTTGAAGAACTCTGTGCTGAACTTCTGCAAAAGATAGAAGTACCCCTTTATTCACTGTTGGAA
CAAACTCATCTCAAAGTAGAAGATGTGAGTGCAGTTGAGATTGTTGGAGGCGCTACACGAATTCCAGCTGTGAAGGAAAGAATTGCCAAA
TTCTTTGGAAAAGATATTAGCACAACACTCAATGCAGATGAAGCAGTAGCCAGAGGATGTGCATTACAGTGTGCAATACTTTCCCCGGCA
TTTAAAGTTAGAGAATTTTCCGTCACAGATGCAGTTCCTTTTCCAATATCTCTGATCTGGAACCATGATTCAGAAGATACTGAAGGTGTT
CATGAAGTCTTTAGTCGAAACCATGCTGCTCCTTTCTCCAAAGTTCTCACCTTTCTGAGAAGGGGGCCTTTTGAGCTAGAAGCTTTCTAT
TCTGATCCCCAAGGAGTTCCATATCCAGAAGCAAAAATAGGCCGCTTTGTAGTTCAGAATGTTTCTGCACAGAAAGATGGAGAAAAATCT
AGAGTAAAAGTCAAAGTGCGAGTCAACACCCATGGCATTTTCACCATCTCTACGGCATCTATGGTGGAGAAAGTCCCAACTGAGGAGAAT
GAAATGTCTTCTGAAGCTGACATGGAGTGTCTGAATCAGAGACCACCAGAAAACCCAGACACTGATAAAAATGTCCAGCAAGACAACAGT
GAAGCTGGAACACAGCCCCAGGTACAAACTGATGCTCAACAAACCTCACAGTCTCCCCCTTCACCTGAACTTACCTCAGAAGAAAACAAA
ATCCCAGATGCTGACAAAGCAAATGAAAAAAAAGTTGACCAGCCTCCAGAAGCTAAAAAGCCCAAAATAAAGGTGGTGAATGTTGAGCTG
CCTATTGAAGCCAACTTGGTCTGGCAGTTAGGGAAAGACCTTCTTAACATGTATATTGAGACAGAGGGTAAGATGATAATGCAAGATAAA
TTGGAAAAAGAAAGGAATGATGCTAAAAATGCAGTTGAGGAATATGTGTATGAGTTCAGAGACAAGCTGTGTGGACCATATGAAAAATTT
ATATGTGAGCAGGATCATCAAAATTTTTTGAGACTCCTCACAGAAACTGAAGACTGGCTGTATGAAGAAGGAGAGGACCAAGCTAAACAA
GCATATGTTGACAAGTTGGAAGAATTAATGAAAATTGGCACTCCAGTTAAAGTTCGGTTTCAGGAAGCTGAAGAACGGCCAAAAATGTTT
GAAGAACTAGGACAGAGGCTGCAGCATTATGCCAAGATAGCAGCTGACTTCAGAAATAAGGATGAGAAATACAACCATATTGATGAGTCT
GAAATGAAAAAAGTGGAGAAGTCTGTTAATGAAGTGATGGAATGGATGAATAATGTCATGAATGCTCAGGCTAAAAAGAGTCTTGATCAG
GATCCAGTTGTACGTGCTCAGGAAATTAAAACAAAAATCAAGGAATTGAACAACACATGTGAACCCGTTGTAACACAACCGAAACCAAAA
ATTGAATCACCCAAACTGGAAAGAACTCCAAATGGCCCAAATATTGATAAAAAGGAAGAAGATTTAGAAGACAAAAACAATTTTGGTGCT
GAACCTCCACATCAGAATGGTGAATGTTACCCTAATGAGAAAAATTCTGTTAATATGGACTTGGACTAGATAACCTTAAATTGGCCTATT
CCTTCAATTAATAAAATATTTTTGCCATAGTATGTGACTCTACATAACATACTGAAACTATTTATATTTTCTTTTTTAAGGATATTTAGA
AATTTTGTGTATTATATGGAAAAAGAAAAAAAGCTTAAGTCTGTAGTCTTTATGATCCTAAAAGGGAAAATTGCCTTGGTAACTTTCAGA
TTCCTGTGGAATTGTGAATTCATACTAAGCTTTCTGTGCAGTCTCACCATTTGCATCACTGAGGATGAAACTGACTTTTGTCTTTTGGAG
AAAAAAAACTGTACTGCTTGTTCAAGAGGGCTGTGATTAAAATCTTTAAGCATTTGTTCCTGCCAAGGTAGTTTTCTTGCATTTTGCTCT
CCATTCAGCATGTGTGTGGGTGTGGATGTTTATAAACAAGACTAAGTCTGACTTCATAAGGGCTTTCTAAAACCATTTCTGTCCAAGAGA
AAATGACTTTTTGCTTTGATATTAAAAATTCAATGAGTAAAACAAAAGCTAGTCAAATGTGTTAGCAGCATGCAGAACAAAAACTTTAAA
CTTTCTCTCTCACTATACAGTATATTGTCATGTGAAAGTGTGGAATGGAAGAAATGTCGATCCTGTTGTAACTGATTGTGAACACTTTTA
TGAGCTTTAAAATAAAGTTCATCTTATGGTGTCATTTCT

>5611_5611_1_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000320027_length(amino acids)=829AA_BP=26
MHSWTWDPHSSEQLDLAQSLSEEDPLQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITA
MLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQ
VSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSG
KMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKV
REFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVK
VKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPD
ADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICE
QDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMK
KVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPP
HQNGECYPNEKNSVNMDLD

--------------------------------------------------------------
>5611_5611_2_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000380405_length(transcript)=3057nt_BP=87nt
ATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGCAA
ATCACTCATGCAAACAATACGGTGTCTAACTTCAAAAGATTTCATGGCCGAGCATTCAATGACCCCTTCATTCAAAAGGAGAAGGAAAAC
TTGAGTTACGATTTGGTTCCATTGAAAAATGGTGGAGTTGGAATAAAGGTAATGTACATGGGTGAAGAACATCTATTTAGTGTGGAGCAG
ATAACAGCCATGTTGTTGACTAAGCTGAAGGAAACTGCTGAAAACAGCCTCAAGAAACCAGTAACAGATTGTGTTATTTCAGTCCCCTCC
TTCTTTACAGATGCTGAGAGGCGATCTGTGTTAGATGCTGCACAGATTGTTGGCCTAAACTGTTTAAGACTTATGAATGACATGACAGCT
GTTGCTTTGAATTACGGAATTTATAAGCAGGATCTCCCAAGCCTGGATGAGAAACCTCGGATAGTGGTTTTTGTTGATATGGGACATTCA
GCTTTTCAAGTGTCTGCTTGTGCTTTTAACAAGGGAAAATTGAAGGTACTGGGAACAGCTTTTGATCCTTTCTTAGGAGGAAAAAACTTC
GATGAAAAGTTAGTGGAACATTTTTGTGCAGAATTTAAAACTAAGTACAAGTTGGATGCAAAATCCAAAATACGAGCACTCCTACGTCTG
TATCAGGAATGTGAAAAACTGAAAAAGCTAATGAGCTCTAACAGCACAGACCTTCCACTGAATATCGAATGCTTTATGAATGATAAAGAT
GTTTCCGGAAAGATGAACAGGTCACAATTTGAAGAACTCTGTGCTGAACTTCTGCAAAAGATAGAAGTACCCCTTTATTCACTGTTGGAA
CAAACTCATCTCAAAGTAGAAGATGTGAGTGCAGTTGAGATTGTTGGAGGCGCTACACGAATTCCAGCTGTGAAGGAAAGAATTGCCAAA
TTCTTTGGAAAAGATATTAGCACAACACTCAATGCAGATGAAGCAGTAGCCAGAGGATGTGCATTACAGTGTGCAATACTTTCCCCGGCA
TTTAAAGTTAGAGAATTTTCCGTCACAGATGCAGTTCCTTTTCCAATATCTCTGATCTGGAACCATGATTCAGAAGATACTGAAGGTGTT
CATGAAGTCTTTAGTCGAAACCATGCTGCTCCTTTCTCCAAAGTTCTCACCTTTCTGAGAAGGGGGCCTTTTGAGCTAGAAGCTTTCTAT
TCTGATCCCCAAGGAGTTCCATATCCAGAAGCAAAAATAGGCCGCTTTGTAGTTCAGAATGTTTCTGCACAGAAAGATGGAGAAAAATCT
AGAGTAAAAGTCAAAGTGCGAGTCAACACCCATGGCATTTTCACCATCTCTACGGCATCTATGGTGGAGAAAGTCCCAACTGAGGAGAAT
GAAATGTCTTCTGAAGCTGACATGGAGTGTCTGAATCAGAGACCACCAGAAAACCCAGACACTGATGCAAATGAAAAAAAAGTTGACCAG
CCTCCAGAAGCTAAAAAGCCCAAAATAAAGGTGGTGAATGTTGAGCTGCCTATTGAAGCCAACTTGGTCTGGCAGTTAGGGAAAGACCTT
CTTAACATGTATATTGAGACAGAGGGTAAGATGATAATGCAAGATAAATTGGAAAAAGAAAGGAATGATGCTAAAAATGCAGTTGAGGAA
TATGTGTATGAGTTCAGAGACAAGCTGTGTGGACCATATGAAAAATTTATATGTGAGCAGGATCATCAAAATTTTTTGAGACTCCTCACA
GAAACTGAAGACTGGCTGTATGAAGAAGGAGAGGACCAAGCTAAACAAGCATATGTTGACAAGTTGGAAGAATTAATGAAAATTGGCACT
CCAGTTAAAGTTCGGTTTCAGGAAGCTGAAGAACGGCCAAAAATGTTTGAAGAACTAGGACAGAGGCTGCAGCATTATGCCAAGATAGCA
GCTGACTTCAGAAATAAGGATGAGAAATACAACCATATTGATGAGTCTGAAATGAAAAAAGTGGAGAAGTCTGTTAATGAAGTGATGGAA
TGGATGAATAATGTCATGAATGCTCAGGCTAAAAAGAGTCTTGATCAGGATCCAGTTGTACGTGCTCAGGAAATTAAAACAAAAATCAAG
GAATTGAACAACACATGTGAACCCGTTGTAACACAACCGAAACCAAAAATTGAATCACCCAAACTGGAAAGAACTCCAAATGGCCCAAAT
ATTGATAAAAAGGAAGAAGATTTAGAAGACAAAAACAATTTTGGTGCTGAACCTCCACATCAGAATGGTGAATGTTACCCTAATGAGAAA
AATTCTGTTAATATGGACTTGGACTAGATAACCTTAAATTGGCCTATTCCTTCAATTAATAAAATATTTTTGCCATAGTATGTGACTCTA
CATAACATACTGAAACTATTTATATTTTCTTTTTTAAGGATATTTAGAAATTTTGTGTATTATATGGAAAAAGAAAAAAAGCTTAAGTCT
GTAGTCTTTATGATCCTAAAAGGGAAAATTGCCTTGGTAACTTTCAGATTCCTGTGGAATTGTGAATTCATACTAAGCTTTCTGTGCAGT
CTCACCATTTGCATCACTGAGGATGAAACTGACTTTTGTCTTTTGGAGAAAAAAAACTGTACTGCTTGTTCAAGAGGGCTGTGATTAAAA
TCTTTAAGCATTTGTTCCTGCCAAGGTAGTTTTCTTGCATTTTGCTCTCCATTCAGCATGTGTGTGGGTGTGGATGTTTATAAACAAGAC
TAAGTCTGACTTCATAAGGGCTTTCTAAAACCATTTCTGTCCAAGAGAAAATGACTTTTTGCTTTGATATTAAAAATTCAATGAGTAAAA
CAAAAGCTAGTCAAATGTGTTAGCAGCATGCAGAACAAAAACTTTAAACTTTCTCTCTCACTATACAGTATATTGTCATGTGAAAGTGTG
GAATGGAAGAAATGTCGATCCTGTTGTAACTGATTGTGAACACTTTTATGAGCTTTAAAATAAAGTTCATCTTATGGTGTCATTTCT

>5611_5611_2_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000380405_length(amino acids)=785AA_BP=26
MHSWTWDPHSSEQLDLAQSLSEEDPLQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITA
MLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQ
VSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSG
KMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKV
REFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVK
VKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNM
YIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVK
VRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELN
NTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD

--------------------------------------------------------------
>5611_5611_3_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000380406_length(transcript)=3066nt_BP=87nt
ATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGCAA
ATCACTCATGCAAACAATACGGTGTCTAACTTCAAAAGATTTCATGGCCGAGCATTCAATGACCCCTTCATTCAAAAGGAGAAGGAAAAC
TTGAGTTACGATTTGGTTCCATTGAAAAATGGTGGAGTTGGAATAAAGGTCCCCTCCTTCTTTACAGATGCTGAGAGGCGATCTGTGTTA
GATGCTGCACAGATTGTTGGCCTAAACTGTTTAAGACTTATGAATGACATGACAGCTGTTGCTTTGAATTACGGAATTTATAAGCAGGAT
CTCCCAAGCCTGGATGAGAAACCTCGGATAGTGGTTTTTGTTGATATGGGACATTCAGCTTTTCAAGTGTCTGCTTGTGCTTTTAACAAG
GGAAAATTGAAGGTACTGGGAACAGCTTTTGATCCTTTCTTAGGAGGAAAAAACTTCGATGAAAAGTTAGTGGAACATTTTTGTGCAGAA
TTTAAAACTAAGTACAAGTTGGATGCAAAATCCAAAATACGAGCACTCCTACGTCTGTATCAGGAATGTGAAAAACTGAAAAAGCTAATG
AGCTCTAACAGCACAGACCTTCCACTGAATATCGAATGCTTTATGAATGATAAAGATGTTTCCGGAAAGATGAACAGGTCACAATTTGAA
GAACTCTGTGCTGAACTTCTGCAAAAGATAGAAGTACCCCTTTATTCACTGTTGGAACAAACTCATCTCAAAGTAGAAGATGTGAGTGCA
GTTGAGATTGTTGGAGGCGCTACACGAATTCCAGCTGTGAAGGAAAGAATTGCCAAATTCTTTGGAAAAGATATTAGCACAACACTCAAT
GCAGATGAAGCAGTAGCCAGAGGATGTGCATTACAGTGTGCAATACTTTCCCCGGCATTTAAAGTTAGAGAATTTTCCGTCACAGATGCA
GTTCCTTTTCCAATATCTCTGATCTGGAACCATGATTCAGAAGATACTGAAGGTGTTCATGAAGTCTTTAGTCGAAACCATGCTGCTCCT
TTCTCCAAAGTTCTCACCTTTCTGAGAAGGGGGCCTTTTGAGCTAGAAGCTTTCTATTCTGATCCCCAAGGAGTTCCATATCCAGAAGCA
AAAATAGGCCGCTTTGTAGTTCAGAATGTTTCTGCACAGAAAGATGGAGAAAAATCTAGAGTAAAAGTCAAAGTGCGAGTCAACACCCAT
GGCATTTTCACCATCTCTACGGCATCTATGGTGGAGAAAGTCCCAACTGAGGAGAATGAAATGTCTTCTGAAGCTGACATGGAGTGTCTG
AATCAGAGACCACCAGAAAACCCAGACACTGATAAAAATGTCCAGCAAGACAACAGTGAAGCTGGAACACAGCCCCAGGTACAAACTGAT
GCTCAACAAACCTCACAGTCTCCCCCTTCACCTGAACTTACCTCAGAAGAAAACAAAATCCCAGATGCTGACAAAGCAAATGAAAAAAAA
GTTGACCAGCCTCCAGAAGCTAAAAAGCCCAAAATAAAGGTGGTGAATGTTGAGCTGCCTATTGAAGCCAACTTGGTCTGGCAGTTAGGG
AAAGACCTTCTTAACATGTATATTGAGACAGAGGGTAAGATGATAATGCAAGATAAATTGGAAAAAGAAAGGAATGATGCTAAAAATGCA
GTTGAGGAATATGTGTATGAGTTCAGAGACAAGCTGTGTGGACCATATGAAAAATTTATATGTGAGCAGGATCATCAAAATTTTTTGAGA
CTCCTCACAGAAACTGAAGACTGGCTGTATGAAGAAGGAGAGGACCAAGCTAAACAAGCATATGTTGACAAGTTGGAAGAATTAATGAAA
ATTGGCACTCCAGTTAAAGTTCGGTTTCAGGAAGCTGAAGAACGGCCAAAAATGTTTGAAGAACTAGGACAGAGGCTGCAGCATTATGCC
AAGATAGCAGCTGACTTCAGAAATAAGGATGAGAAATACAACCATATTGATGAGTCTGAAATGAAAAAAGTGGAGAAGTCTGTTAATGAA
GTGATGGAATGGATGAATAATGTCATGAATGCTCAGGCTAAAAAGAGTCTTGATCAGGATCCAGTTGTACGTGCTCAGGAAATTAAAACA
AAAATCAAGGAATTGAACAACACATGTGAACCCGTTGTAACACAACCGAAACCAAAAATTGAATCACCCAAACTGGAAAGAACTCCAAAT
GGCCCAAATATTGATAAAAAGGAAGAAGATTTAGAAGACAAAAACAATTTTGGTGCTGAACCTCCACATCAGAATGGTGAATGTTACCCT
AATGAGAAAAATTCTGTTAATATGGACTTGGACTAGATAACCTTAAATTGGCCTATTCCTTCAATTAATAAAATATTTTTGCCATAGTAT
GTGACTCTACATAACATACTGAAACTATTTATATTTTCTTTTTTAAGGATATTTAGAAATTTTGTGTATTATATGGAAAAAGAAAAAAAG
CTTAAGTCTGTAGTCTTTATGATCCTAAAAGGGAAAATTGCCTTGGTAACTTTCAGATTCCTGTGGAATTGTGAATTCATACTAAGCTTT
CTGTGCAGTCTCACCATTTGCATCACTGAGGATGAAACTGACTTTTGTCTTTTGGAGAAAAAAAACTGTACTGCTTGTTCAAGAGGGCTG
TGATTAAAATCTTTAAGCATTTGTTCCTGCCAAGGTAGTTTTCTTGCATTTTGCTCTCCATTCAGCATGTGTGTGGGTGTGGATGTTTAT
AAACAAGACTAAGTCTGACTTCATAAGGGCTTTCTAAAACCATTTCTGTCCAAGAGAAAATGACTTTTTGCTTTGATATTAAAAATTCAA
TGAGTAAAACAAAAGCTAGTCAAATGTGTTAGCAGCATGCAGAACAAAAACTTTAAACTTTCTCTCTCACTATACAGTATATTGTCATGT
GAAAGTGTGGAATGGAAGAAATGTCGATCCTGTTGTAACTGATTGTGAACACTTTTATGAGCTTTAAAATAAAGTTCATCTTATGGTGTC
ATTTCT

>5611_5611_3_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000380406_length(amino acids)=788AA_BP=26
MHSWTWDPHSSEQLDLAQSLSEEDPLQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVPSFFTDAERRSVLDAA
QIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKT
KYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEI
VGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSK
VLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQR
PPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPDADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDL
LNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICEQDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGT
PVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIK
ELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPPHQNGECYPNEKNSVNMDLD

--------------------------------------------------------------
>5611_5611_4_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000445273_length(transcript)=2896nt_BP=87nt
ATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGTCTCTGTCAGAGGAAGATCCCTTGCAA
ATCACTCATGCAAACAATACGGTGTCTAACTTCAAAAGATTTCATGGCCGAGCATTCAATGACCCCTTCATTCAAAAGGAGAAGGAAAAC
TTGAGTTACGATTTGGTTCCATTGAAAAATGGTGGAGTTGGAATAAAGGTAATGTACATGGGTGAAGAACATCTATTTAGTGTGGAGCAG
ATAACAGCCATGTTGTTGACTAAGCTGAAGGAAACTGCTGAAAACAGCCTCAAGAAACCAGTAACAGATTGTGTTATTTCAGTCCCCTCC
TTCTTTACAGATGCTGAGAGGCGATCTGTGTTAGATGCTGCACAGATTGTTGGCCTAAACTGTTTAAGACTTATGAATGACATGACAGCT
GTTGCTTTGAATTACGGAATTTATAAGCAGGATCTCCCAAGCCTGGATGAGAAACCTCGGATAGTGGTTTTTGTTGATATGGGACATTCA
GCTTTTCAAGTGTCTGCTTGTGCTTTTAACAAGGGAAAATTGAAGGTACTGGGAACAGCTTTTGATCCTTTCTTAGGAGGAAAAAACTTC
GATGAAAAGTTAGTGGAACATTTTTGTGCAGAATTTAAAACTAAGTACAAGTTGGATGCAAAATCCAAAATACGAGCACTCCTACGTCTG
TATCAGGAATGTGAAAAACTGAAAAAGCTAATGAGCTCTAACAGCACAGACCTTCCACTGAATATCGAATGCTTTATGAATGATAAAGAT
GTTTCCGGAAAGATGAACAGGTCACAATTTGAAGAACTCTGTGCTGAACTTCTGCAAAAGATAGAAGTACCCCTTTATTCACTGTTGGAA
CAAACTCATCTCAAAGTAGAAGATGTGAGTGCAGTTGAGATTGTTGGAGGCGCTACACGAATTCCAGCTGTGAAGGAAAGAATTGCCAAA
TTCTTTGGAAAAGATATTAGCACAACACTCAATGCAGATGAAGCAGTAGCCAGAGGATGTGCATTACAGTGTGCAATACTTTCCCCGGCA
TTTAAAGTTAGAGAATTTTCCGTCACAGATGCAGTTCCTTTTCCAATATCTCTGATCTGGAACCATGATTCAGAAGATACTGAAGGTGTT
CATGAAGTCTTTAGTCGAAACCATGCTGCTCCTTTCTCCAAAGTTCTCACCTTTCTGAGAAGGGGGCCTTTTGAGCTAGAAGCTTTCTAT
TCTGATCCCCAAGGAGTTCCATATCCAGAAGCAAAAATAGGCCGCTTTGTAGTTCAGAATGTTTCTGCACAGAAAGATGGAGAAAAATCT
AGAGTAAAAGTCAAAGTGCGAGTCAACACCCATGGCATTTTCACCATCTCTACGGCATCTATGGTGGAGAAAGTCCCAACTGAGGAGAAT
GAAATGTCTTCTGAAGCTGACATGGAGTGTCTGAATCAGAGACCACCAGAAAACCCAGACACTGATAAAAATGTCCAGCAAGACAACAGT
GAAGCTGGAACACAGCCCCAGGTACAAACTGATGCTCAACAAACCTCACAGTCTCCCCCTTCACCTGAACTTACCTCAGAAGAAAACAAA
ATCCCAGATGCTGACAAAGCAAATGAAAAAAAAGTTGACCAGCCTCCAGAAGCTAAAAAGCCCAAAATAAAGGTGGTGAATGTTGAGCTG
CCTATTGAAGCCAACTTGGTCTGGCAGTTAGGGAAAGACCTTCTTAACATGTATATTGAGACAGAGGGTAAGATGATAATGCAAGATAAA
TTGGAAAAAGAAAGGAATGATGCTAAAAATGCAGTTGAGGAATATGTGTATGAGTTCAGAGACAAGCTGTGTGGACCATATGAAAAATTT
ATATGTGAGCAGGATCATCAAAATTTTTTGAGACTCCTCACAGAAACTGAAGACTGGCTGTATGAAGAAGGAGAGGACCAAGCTAAACAA
GCATATGTTGACAAGTTGGAAGAATTAATGAAAATTGGCACTCCAGTTAAAGTTCGGTTTCAGGAAGCTGAAGAACGGCCAAAAATGTTT
GAAGAACTAGGACAGAGGCTGCAGCATTATGCCAAGATAGCAGCTGACTTCAGAAATAAGGATGAGAAATACAACCATATTGATGAGTCT
GAAATGAAAAAAGTGGAGAAGTCTGTTAATGAAGTGATGGAATGGATGAATAATGTCATGAATGCTCAGGCTAAAAAGAGTCTTGATCAG
GATCCAGTTGTACGTGCTCAGGAAATTAAAACAAAAATCAAGGAATTGAACAACACATGTGAACCCGTTGTAACACAACCGAAACCAAAA
ATTGAATCACCCAAACTGGAAAGAACTCCAAATGGCCCAAATATTGATAAAAAGGAAGAAGATTTAGAAGACAAAAACAATTTTGGTGCT
GAACCTCCACATCAGAATGGTGAATGTTACCCTAATGAGAAAAATTCTGTTAATATGGACTTGGACTAGATAACCTTAAATTGGCCTATT
CCTTCAATTAATAAAATATTTTTGCCATAGTATGTGACTCTACATAACATACTGAAACTATTTATATTTTCTTTTTTAAGGATATTTAGA
AATTTTGTGTATTATATGGAAAAAGAAAAAAAGCTTAAGTCTGTAGTCTTTATGATCCTAAAAGGGAAAATTGCCTTGGTAACTTTCAGA
TTCCTGTGGAATTGTGAATTCATACTAAGCTTTCTGTGCAGTCTCACCATTTGCATCACTGAGGATGAAACTGACTTTTGTCTTTTGGAG
AAAAAAAACTGTACTGCTTGTTCAAGAGGGCTGTGATTAAAATCTTTAAGCATTTGTTCCTGCCAAGGTAGTTTTCTTGCATTTTGCTCT
CCATTCAGCATGTGTG

>5611_5611_4_APOL2-HSPH1_APOL2_chr22_36635487_ENST00000451256_HSPH1_chr13_31729791_ENST00000445273_length(amino acids)=829AA_BP=26
MHSWTWDPHSSEQLDLAQSLSEEDPLQITHANNTVSNFKRFHGRAFNDPFIQKEKENLSYDLVPLKNGGVGIKVMYMGEEHLFSVEQITA
MLLTKLKETAENSLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPSLDEKPRIVVFVDMGHSAFQ
VSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLYQECEKLKKLMSSNSTDLPLNIECFMNDKDVSG
KMNRSQFEELCAELLQKIEVPLYSLLEQTHLKVEDVSAVEIVGGATRIPAVKERIAKFFGKDISTTLNADEAVARGCALQCAILSPAFKV
REFSVTDAVPFPISLIWNHDSEDTEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVK
VKVRVNTHGIFTISTASMVEKVPTEENEMSSEADMECLNQRPPENPDTDKNVQQDNSEAGTQPQVQTDAQQTSQSPPSPELTSEENKIPD
ADKANEKKVDQPPEAKKPKIKVVNVELPIEANLVWQLGKDLLNMYIETEGKMIMQDKLEKERNDAKNAVEEYVYEFRDKLCGPYEKFICE
QDHQNFLRLLTETEDWLYEEGEDQAKQAYVDKLEELMKIGTPVKVRFQEAEERPKMFEELGQRLQHYAKIAADFRNKDEKYNHIDESEMK
KVEKSVNEVMEWMNNVMNAQAKKSLDQDPVVRAQEIKTKIKELNNTCEPVVTQPKPKIESPKLERTPNGPNIDKKEEDLEDKNNFGAEPP
HQNGECYPNEKNSVNMDLD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for APOL2-HSPH1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOL2-HSPH1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOL2-HSPH1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOL2C0006868Cannabis Abuse1CTD_human
HgeneAPOL2C0006870Cannabis Dependence1CTD_human
HgeneAPOL2C0009171Cocaine Abuse1CTD_human
HgeneAPOL2C0018614Hashish Abuse1CTD_human
HgeneAPOL2C0024809Marijuana Abuse1CTD_human
HgeneAPOL2C0031391Phencyclidine Abuse1CTD_human
HgeneAPOL2C0236735Cannabis-Related Disorder1CTD_human
HgeneAPOL2C0236736Cocaine-Related Disorders1CTD_human
HgeneAPOL2C0236742Phencyclidine-Related Disorders1CTD_human
HgeneAPOL2C0600427Cocaine Dependence1CTD_human
TgeneC0019693HIV Infections1CTD_human
TgeneC4505456HIV Coinfection1CTD_human