Fusion Gene Studies
in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:APOL2-ULK2 (FusionGDB2 ID:HG23780TG9706)

Fusion Gene Summary for APOL2-ULK2

check button Fusion gene summary
Fusion gene informationFusion gene name: APOL2-ULK2
Fusion gene ID: hg23780tg9706
HgeneTgene
Gene symbol

APOL2

ULK2

Gene ID

23780

9706

Gene nameapolipoprotein L2unc-51 like autophagy activating kinase 2
SynonymsAPOL-II|APOL3ATG1B|Unc51.2
Cytomap('APOL2')('ULK2')

22q12.3

17p11.2

Type of geneprotein-codingprotein-coding
Descriptionapolipoprotein L2apolipoprotein L, 2apolipoprotein L-IIserine/threonine-protein kinase ULK2
Modification date2020031320200313
UniProtAcc

Q9BQE5

.
Ensembl transtripts involved in fusion geneENST00000249066, ENST00000358502, 
ENST00000451256, ENST00000476579, 
Fusion gene scores* DoF score7 X 4 X 7=1969 X 7 X 6=378
# samples 710
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: APOL2 [Title/Abstract] AND ULK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAPOL2(36627386)-ULK2(19729499), # samples:2
Anticipated loss of major functional domain due to fusion event.APOL2-ULK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOL2-ULK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
APOL2-ULK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOL2-ULK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
APOL2-ULK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
APOL2-ULK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneULK2

GO:0006914

autophagy

18936157

TgeneULK2

GO:0046777

protein autophosphorylation

18936157


check buttonFusion gene breakpoints across APOL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ULK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-33-6737-01AAPOL2chr22

36627386

-ULK2chr17

19729499

-


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Fusion Gene ORF analysis for APOL2-ULK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000249066ENST00000580130APOL2chr22

36627386

-ULK2chr17

19729499

-
5CDS-intronENST00000358502ENST00000580130APOL2chr22

36627386

-ULK2chr17

19729499

-
5CDS-intronENST00000451256ENST00000580130APOL2chr22

36627386

-ULK2chr17

19729499

-
Frame-shiftENST00000249066ENST00000361658APOL2chr22

36627386

-ULK2chr17

19729499

-
Frame-shiftENST00000249066ENST00000395544APOL2chr22

36627386

-ULK2chr17

19729499

-
Frame-shiftENST00000451256ENST00000361658APOL2chr22

36627386

-ULK2chr17

19729499

-
Frame-shiftENST00000451256ENST00000395544APOL2chr22

36627386

-ULK2chr17

19729499

-
In-frameENST00000358502ENST00000361658APOL2chr22

36627386

-ULK2chr17

19729499

-
In-frameENST00000358502ENST00000395544APOL2chr22

36627386

-ULK2chr17

19729499

-
intron-3CDSENST00000476579ENST00000361658APOL2chr22

36627386

-ULK2chr17

19729499

-
intron-3CDSENST00000476579ENST00000395544APOL2chr22

36627386

-ULK2chr17

19729499

-
intron-intronENST00000476579ENST00000580130APOL2chr22

36627386

-ULK2chr17

19729499

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000358502APOL2chr2236627386-ENST00000361658ULK2chr1719729499-30754734242796790
ENST00000358502APOL2chr2236627386-ENST00000395544ULK2chr1719729499-51964734242796790

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358502ENST00000361658APOL2chr2236627386-ULK2chr1719729499-0.0078888050.9921112
ENST00000358502ENST00000395544APOL2chr2236627386-ULK2chr1719729499-0.0012420110.99875796

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Fusion Genomic Features for APOL2-ULK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for APOL2-ULK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:36627386/chr17:19729499)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
APOL2

Q9BQE5

.
FUNCTION: May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneULK2chr22:36627386chr17:19729499ENST00000361658928812_1036262915.3333333333334RegionNote=CTD-like region
TgeneULK2chr22:36627386chr17:19729499ENST00000395544927812_10362621037.0RegionNote=CTD-like region

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAPOL2chr22:36627386chr17:19729499ENST00000249066-56157_16245338.0Compositional biasNote=Poly-Ala
HgeneAPOL2chr22:36627386chr17:19729499ENST00000358502-45157_16245338.0Compositional biasNote=Poly-Ala
TgeneULK2chr22:36627386chr17:19729499ENST000003616589289_271262915.3333333333334DomainProtein kinase
TgeneULK2chr22:36627386chr17:19729499ENST000003955449279_2712621037.0DomainProtein kinase
TgeneULK2chr22:36627386chr17:19729499ENST0000036165892815_23262915.3333333333334Nucleotide bindingATP
TgeneULK2chr22:36627386chr17:19729499ENST0000039554492715_232621037.0Nucleotide bindingATP


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Fusion Gene Sequence for APOL2-ULK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>5617_5617_1_APOL2-ULK2_APOL2_chr22_36627386_ENST00000358502_ULK2_chr17_19729499_ENST00000361658_length(transcript)=3075nt_BP=473nt
GTGCTGGGGAGCAGCGTGTTTACTGTGCTTGGTCATGAGCTGCTGGGAAGTTGTGACTTTCACTTTCCCTTTCGAATTCCAGGGTATATC
TGGGAGGCCGGAGGACGTGTCTGGTTATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGT
CTCTGTCAGAGGAAGATCCCTTGGACAAGAGGACCCTGCCTTGGTGTGAGAGTGAGGGAAGAGGAAGCTGGAACGAGGGTTAAGGAAAAC
CTTCCAGTCTGGACAGTGACTGGAGAGCTCCAAGGAAAGCCCCTCGGTAACCCAGCCGCTGGCACCATGAACCCAGAGAGCAGTATCTTT
ATTGAGGATTACCTTAAGTATTTCCAGGACCAAGTGAGCAGAGAGAATCTGCTACAACTGCTGACTGATGATGAAGCCTGGAATGGATTC
GTGGCTGCTGCTGAACTGCCCAGAAGCATTTTTTAGCCATCCTTTTCTTGAGCAAGGTCCAGTAAAAAAATCTTGCCCAGTTCCAGTGCC
CATGTATTCTGGTTCTGTCTCTGGAAGCTCCTGTGGCAGCTCTCCATCTTGTCGTTTTGCTTCTCCACCATCCCTTCCAGATATGCAGCA
TATTCAGGAAGAAAACTTATCTTCCCCACCATTGGGTCCTCCCAACTATCTACAAGTTTCCAAAGATTCTGCCAGTACTAGTAGCAAGAA
CTCTTCTTGTGACACGGATGACTTTGTTTTGGTGCCACACAACATCTCGTCAGACCACTCATGTGATATGCCAGTGGGGACTGCTGGCAG
ACGTGCTTCAAATGAATTCTTGGTGTGTGGAGGGCAGTGTCAGCCTACTGTGTCACCTCACAGCGAAACAGCACCAATTCCAGTTCCTAC
TCAAATAAGGAATTATCAGCGCATAGAGCAGAATCTTACATCTACTGCCAGCTCAGGCACAAATGTACATGGTTCTCCAAGATCTGCAGT
GGTACGAAGGTCCAACACCAGCCCCATGGGCTTCCTCCGGCCGGGATCATGCTCCCCAGTACCAGCAGACACAGCACAGACAGTTGGACG
AAGGCTCTCCACTGGGTCTTCTAGGCCTTACTCACCTTCCCCTTTGGTTGGTACCATTCCTGAGCAATTCAGTCAGTGCTGCTGTGGGCA
TCCTCAGGGCCATGACTCCAGGAGTAGAAACTCCTCAGGTTCTCCAGTGCCACAAGCTCAGTCCCCACAGTCTCTCTTATCGGGTGCTAG
ACTGCAGAGCGCCCCCACCCTCACTGACATCTATCAGAACAAGCAGAAGCTCAGAAAACAGCACTCTGACCCCGTGTGCCCATCCCATAC
TGGGGCTGGGTACAGCTACTCGCCTCAGCCCAGTCGGCCTGGCAGCCTTGGAACTTCTCCCACCAAGCACTTGGGGTCCTCTCCACGGAG
TTCTGACTGGTTCTTTAAAACTCCTTTGCCAACAATCATTGGCTCTCCTACTAAGACCACAGCTCCTTTCAAAATCCCTAAAACTCAAGC
ATCTTCCAACCTGTTAGCCTTGGTTACTCGTCATGGGCCTGCTGAAGAACAGTCGAAAGATGGGAATGAGCCACGGGAATGTGCCCATTG
CCTCTTAGTGCAAGGAAGTGAGAGGCAGCGGGCCGAGCAGCAGAGCAAGGCAGTGTTTGGCAGATCTGTCAGTACCGGGAAGTTATCAGA
TCAACAAGGAAAGACTCCTATATGTCGACATCAGGGCAGCACAGACAGTTTAAATACAGAACGACCAATGGATATAGCTCCGGCAGGAGC
CTGTGGTGGTGTTCTGGCACCTCCTGCAGGTACAGCAGCAAGTTCCAAGGCTGTCCTCTTCACTGTAGGGTCTCCTCCACACAGTGCGGC
AGCCCCCACTTGTACCCACATGTTCCTTCGAACAAGAACAACCTCAGTGGGGCCCAGCAACTCCGGGGGCTCTCTTTGTGCCATGAGTGG
CCGCGTGTGCGTGGGGTCCCCGCCTGGCCCAGGCTTCGGCTCTTCCCCTCCAGGAGCAGAGGCAGCTCCCAGCCTGAGATACGTGCCTTA
CGGTGCTTCACCCCCCAGCCTAGAGGGGCTCATCACCTTTGAAGCCCCTGAACTGCCGGAGGAGACGCTGATGGAGCGGGAACACACAGA
CACCTTACGCCATCTGAATGTGATGCTGATGTTCACTGAGTGTGTGCTGGACCTGACAGCCATGAGGGGAGGAAACCCTGAGCTGTGCAC
ATCTGCTGTGTCCTTGTACCAGATCCAGGAGAGTGTGGTGGTGGACCAGATCAGTCAGCTGAGCAAAGACTGGGGGCGGGTGGAGCAGCT
GGTGTTGTACATGAAAGCAGCACAGCTGCTTGCGGCTTCTCTGCATCTTGCCAAAGCCCAGATCAAGTCCGGGAAACTGAGCCCATCCAC
AGCTGTGAAACAAGTTGTCAAGAATCTGAACGAACGATATAAATTCTGCATCACCATGTGCAAGAAACTTACAGAAAAGCTGAATCGATT
CTTCTCTGACAAACAGAGGTTTATTGATGAAATCAACAGTGTGACTGCAGAGAAACTCATCTATAATTGTGCTGTAGAAATGGTTCAGTC
TGCAGCCCTGGATGAGATGTTTCAGCAGACCGAAGATATTGTTTATCGCTATCATAAGGCAGCCCTTCTTTTGGAAGGCCTAAGTAGGAT
TCTACAGGACCCTGCAGATATTGAAAATGTGCATAAATATAAATGTAGTATTGAGAGAAGACTGTCGGCGCTCTGCCATAGCACCGCAAC
CGTGTGAGCAGCAGGCTCATCCCGTGGACCGGTGGTGGGAACGTGAGGAAGAGGGGAAGGAAGGAAGAGCTTTTCCATTTGGTGCTCCAA
TGTCTCCTGCTGGACCCATCTGCCTAGTGGAAGGCAGCAAAATTTCAAGAAACAGGTGAGGTTGAGCAGCTTGGTGCAACCCCATGGGGC
CTGGAGTTGGAGCTCAACAGCAATGGATTTCAGAGACCACCCTGAAACTCCCAGTAAAAAAGACTTGGGAGACATGTTAATAAACTCAAG

>5617_5617_1_APOL2-ULK2_APOL2_chr22_36627386_ENST00000358502_ULK2_chr17_19729499_ENST00000361658_length(amino acids)=790AA_BP=16
MMMKPGMDSWLLLNCPEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSK
DSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTN
VHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQS
PQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTA
PFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTER
PMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEA
APSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLS
KDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIY

--------------------------------------------------------------
>5617_5617_2_APOL2-ULK2_APOL2_chr22_36627386_ENST00000358502_ULK2_chr17_19729499_ENST00000395544_length(transcript)=5196nt_BP=473nt
GTGCTGGGGAGCAGCGTGTTTACTGTGCTTGGTCATGAGCTGCTGGGAAGTTGTGACTTTCACTTTCCCTTTCGAATTCCAGGGTATATC
TGGGAGGCCGGAGGACGTGTCTGGTTATTACACAGATGCACAGCTGGACGTGGGATCCACACAGCTCAGAACAGTTGGATCTTGCTCAGT
CTCTGTCAGAGGAAGATCCCTTGGACAAGAGGACCCTGCCTTGGTGTGAGAGTGAGGGAAGAGGAAGCTGGAACGAGGGTTAAGGAAAAC
CTTCCAGTCTGGACAGTGACTGGAGAGCTCCAAGGAAAGCCCCTCGGTAACCCAGCCGCTGGCACCATGAACCCAGAGAGCAGTATCTTT
ATTGAGGATTACCTTAAGTATTTCCAGGACCAAGTGAGCAGAGAGAATCTGCTACAACTGCTGACTGATGATGAAGCCTGGAATGGATTC
GTGGCTGCTGCTGAACTGCCCAGAAGCATTTTTTAGCCATCCTTTTCTTGAGCAAGGTCCAGTAAAAAAATCTTGCCCAGTTCCAGTGCC
CATGTATTCTGGTTCTGTCTCTGGAAGCTCCTGTGGCAGCTCTCCATCTTGTCGTTTTGCTTCTCCACCATCCCTTCCAGATATGCAGCA
TATTCAGGAAGAAAACTTATCTTCCCCACCATTGGGTCCTCCCAACTATCTACAAGTTTCCAAAGATTCTGCCAGTACTAGTAGCAAGAA
CTCTTCTTGTGACACGGATGACTTTGTTTTGGTGCCACACAACATCTCGTCAGACCACTCATGTGATATGCCAGTGGGGACTGCTGGCAG
ACGTGCTTCAAATGAATTCTTGGTGTGTGGAGGGCAGTGTCAGCCTACTGTGTCACCTCACAGCGAAACAGCACCAATTCCAGTTCCTAC
TCAAATAAGGAATTATCAGCGCATAGAGCAGAATCTTACATCTACTGCCAGCTCAGGCACAAATGTACATGGTTCTCCAAGATCTGCAGT
GGTACGAAGGTCCAACACCAGCCCCATGGGCTTCCTCCGGCCGGGATCATGCTCCCCAGTACCAGCAGACACAGCACAGACAGTTGGACG
AAGGCTCTCCACTGGGTCTTCTAGGCCTTACTCACCTTCCCCTTTGGTTGGTACCATTCCTGAGCAATTCAGTCAGTGCTGCTGTGGGCA
TCCTCAGGGCCATGACTCCAGGAGTAGAAACTCCTCAGGTTCTCCAGTGCCACAAGCTCAGTCCCCACAGTCTCTCTTATCGGGTGCTAG
ACTGCAGAGCGCCCCCACCCTCACTGACATCTATCAGAACAAGCAGAAGCTCAGAAAACAGCACTCTGACCCCGTGTGCCCATCCCATAC
TGGGGCTGGGTACAGCTACTCGCCTCAGCCCAGTCGGCCTGGCAGCCTTGGAACTTCTCCCACCAAGCACTTGGGGTCCTCTCCACGGAG
TTCTGACTGGTTCTTTAAAACTCCTTTGCCAACAATCATTGGCTCTCCTACTAAGACCACAGCTCCTTTCAAAATCCCTAAAACTCAAGC
ATCTTCCAACCTGTTAGCCTTGGTTACTCGTCATGGGCCTGCTGAAGAACAGTCGAAAGATGGGAATGAGCCACGGGAATGTGCCCATTG
CCTCTTAGTGCAAGGAAGTGAGAGGCAGCGGGCCGAGCAGCAGAGCAAGGCAGTGTTTGGCAGATCTGTCAGTACCGGGAAGTTATCAGA
TCAACAAGGAAAGACTCCTATATGTCGACATCAGGGCAGCACAGACAGTTTAAATACAGAACGACCAATGGATATAGCTCCGGCAGGAGC
CTGTGGTGGTGTTCTGGCACCTCCTGCAGGTACAGCAGCAAGTTCCAAGGCTGTCCTCTTCACTGTAGGGTCTCCTCCACACAGTGCGGC
AGCCCCCACTTGTACCCACATGTTCCTTCGAACAAGAACAACCTCAGTGGGGCCCAGCAACTCCGGGGGCTCTCTTTGTGCCATGAGTGG
CCGCGTGTGCGTGGGGTCCCCGCCTGGCCCAGGCTTCGGCTCTTCCCCTCCAGGAGCAGAGGCAGCTCCCAGCCTGAGATACGTGCCTTA
CGGTGCTTCACCCCCCAGCCTAGAGGGGCTCATCACCTTTGAAGCCCCTGAACTGCCGGAGGAGACGCTGATGGAGCGGGAACACACAGA
CACCTTACGCCATCTGAATGTGATGCTGATGTTCACTGAGTGTGTGCTGGACCTGACAGCCATGAGGGGAGGAAACCCTGAGCTGTGCAC
ATCTGCTGTGTCCTTGTACCAGATCCAGGAGAGTGTGGTGGTGGACCAGATCAGTCAGCTGAGCAAAGACTGGGGGCGGGTGGAGCAGCT
GGTGTTGTACATGAAAGCAGCACAGCTGCTTGCGGCTTCTCTGCATCTTGCCAAAGCCCAGATCAAGTCCGGGAAACTGAGCCCATCCAC
AGCTGTGAAACAAGTTGTCAAGAATCTGAACGAACGATATAAATTCTGCATCACCATGTGCAAGAAACTTACAGAAAAGCTGAATCGATT
CTTCTCTGACAAACAGAGGTTTATTGATGAAATCAACAGTGTGACTGCAGAGAAACTCATCTATAATTGTGCTGTAGAAATGGTTCAGTC
TGCAGCCCTGGATGAGATGTTTCAGCAGACCGAAGATATTGTTTATCGCTATCATAAGGCAGCCCTTCTTTTGGAAGGCCTAAGTAGGAT
TCTACAGGACCCTGCAGATATTGAAAATGTGCATAAATATAAATGTAGTATTGAGAGAAGACTGTCGGCGCTCTGCCATAGCACCGCAAC
CGTGTGAGCAGCAGGCTCATCCCGTGGACCGGTGGTGGGAACGTGAGGTGATGCCTTTGGGATTACAGCTTGAGTTCTGTCACCCCATCC
CCAGGAAACTGTAGCTTCTTAACTGGTGACTACCAAAGAACAAGCAGTGATTTGAAAAAGGAAAAACAATCCAAAAACTACATATTTGTA
GGAAATCTGCCTTATTGGAGAAAATCACCCTTTCCCTTTTTCTTTGTAGAAGCAGGAGCAAGAGTGTTTGGCTCCCAGTTTGGACTTGGT
GAATAAATGTACCTTAGAACTAGGATAATCGGTACAGTTATTCTTAAAGATAATTAAAAATGAAACAAAGTGAGTGCTCGTCACTGGGTT
CATCAGAGCAGTGTGTGAAATTCCATGTGTTTGCTGAGGTGTAAAGGTAAATGTATTCACCCCTCATCCAGGCAGTTTGATATTTGGAGT
AAGTTTGTTTAAATCTGAGCATGCATCTTTAAACAGCTCAGGAAGAAATAGCTTAAGAAGAAGTGAAACATGGATCTTGGAAGAAATTTT
GAAATCTTCAATTTGATCCTAATATGGATACATGTTAATCTTCCAAAATCTTTCATATTGCACTAATTTATTAAAACAACTGTGTATTGG
ATTTTGTAATTTAACTAAGGCACAATGGACTTGTTTAAAATATTTTACTTGATTGTATACATAGACCCTTTCCAGAATTCACATGTAATC
TCCAGTGAACTTTTAAGTGGTTAAAACTTGTATTCATGTGAACCTTTGCACATTTTTTTTTTTTACTTCTTTATCTACACCTACAGATTT
TCTCAGTAATGTTTTTGTTAGCTTTTGGTTCCATTTTTTATTGTGCATGCAGAATGTACATTGATGCCTGTGACCTTAGGTTTATTAAAG
GCTAGGTTTATTTGGGCAGTATTAGAAACAAAATCATGGATCAAGAGATACTCTTGATAATTTGAATAGGGCCAAAACAAAGTTGGTGAC
CTAAAGGCTTGTTAGTGATGTGGAGTTCCTACATGCAGTGAGTGGAAAATGAAGTTCGTTTTCTCTTAGGAAAATGGGCAGCTGTCTTCT
GCCTAATGTGTATTTTTCATGTTAATTCTGACAGTTCACCAAATAGCTAGTCATGGAGAATGCAGGCAGTTAACTTAATATCCCTCCAGG
AATGGTTCCTACGTTGTGTATTACTTGGTTTCTTTTACTTACCTGCTTGAATACTTGAATAAACCATTCACCAATTTTAATCCTTTTATT
TTAATCCTTTTACATAAAATAATCTGAACTCTTTGACAAATTGCACAGAGCTCTTTGGCATTAATCTAATTTTAATGTACTGATAAAAAC
AAACATGGTTTTCCTTTACTTTGACAAAGTAATGTAATTTTTACCTTATTTATCTGTATGAAATTCCAGTAGTTAATTTGAACATTTATT
TATATGACGTTTGTATTTTTAGGTCTTTAATACAGTGTTTCTACCTCTCATTTGTAACTGCATGCATTATTCTTGAAACTAGGTAAAACT
CACTGAATTGTTGTGTAATAGCCTTTTTATTATTGCCTGTACAAATGTATATTAAGGTAAAATAAAACTGACAAAGTGTTTCTAGGGTGT
AGCTGGGTACATATTAAGTGGCTTGTTGAGCCAGGTACTTCCTTAGTGAGTTTAGAGACTTGGCCATGAATATCCTTTGTCCTGCCCCAG
GATTTAGATCTTGGCTACTGTCATGCAGGCTTCCAGGAACATAGACTGTTTTACCTCCACAACCCTATTTGTTATTAGTGATACTTTATT
TTATATAATATTTTTTATTCACAGTGAAATTTCATTCATGTTCTTTCAGTTATCACCTGTGTTATCTCAGTTGTAGGTTTATTCTATCCT
CTCCTCTTCCTCTCCCATTTCTTTTTTAAGACAGGATGAAACAGGTTCAGAGAGGGGAAGTGATTGGCCTAAAGTCAGGAACTAGGCAAG
TGGTCAAGCCATGCTTTGTGACTTTCAAGTTAATTCTTCTTGTTCTTGTATATTAAAGGTCTTGGGGTAGATGGTGTGTGTGAAACAGTG
AAGTCTCAACAGCAGAAAAGAACAAAATGTAAATTCATGAATAATGGTTCTGGTTATACTTCCATTATCAAGGCTAATTAAGAGATTTTG
CCTTGAGTATAGCAATAATAAACAAATGCTTTATGTTTCCCTGAGTATTTTTAAATTTCATATCGTGTTTCATAGAGTGGAAATGTACCA
GTTCATACATTCATGGGTTGACACCTGTATTCAAGCCATAACCTGGAAAATTGCTGACCAGCTATTCCTGCTCTAAGGGTTTGCTTTAAC

>5617_5617_2_APOL2-ULK2_APOL2_chr22_36627386_ENST00000358502_ULK2_chr17_19729499_ENST00000395544_length(amino acids)=790AA_BP=16
MMMKPGMDSWLLLNCPEAFFSHPFLEQGPVKKSCPVPVPMYSGSVSGSSCGSSPSCRFASPPSLPDMQHIQEENLSSPPLGPPNYLQVSK
DSASTSSKNSSCDTDDFVLVPHNISSDHSCDMPVGTAGRRASNEFLVCGGQCQPTVSPHSETAPIPVPTQIRNYQRIEQNLTSTASSGTN
VHGSPRSAVVRRSNTSPMGFLRPGSCSPVPADTAQTVGRRLSTGSSRPYSPSPLVGTIPEQFSQCCCGHPQGHDSRSRNSSGSPVPQAQS
PQSLLSGARLQSAPTLTDIYQNKQKLRKQHSDPVCPSHTGAGYSYSPQPSRPGSLGTSPTKHLGSSPRSSDWFFKTPLPTIIGSPTKTTA
PFKIPKTQASSNLLALVTRHGPAEEQSKDGNEPRECAHCLLVQGSERQRAEQQSKAVFGRSVSTGKLSDQQGKTPICRHQGSTDSLNTER
PMDIAPAGACGGVLAPPAGTAASSKAVLFTVGSPPHSAAAPTCTHMFLRTRTTSVGPSNSGGSLCAMSGRVCVGSPPGPGFGSSPPGAEA
APSLRYVPYGASPPSLEGLITFEAPELPEETLMEREHTDTLRHLNVMLMFTECVLDLTAMRGGNPELCTSAVSLYQIQESVVVDQISQLS
KDWGRVEQLVLYMKAAQLLAASLHLAKAQIKSGKLSPSTAVKQVVKNLNERYKFCITMCKKLTEKLNRFFSDKQRFIDEINSVTAEKLIY

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Fusion Gene PPI Analysis for APOL2-ULK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for APOL2-ULK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for APOL2-ULK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAPOL2C0006868Cannabis Abuse1CTD_human
HgeneAPOL2C0006870Cannabis Dependence1CTD_human
HgeneAPOL2C0009171Cocaine Abuse1CTD_human
HgeneAPOL2C0018614Hashish Abuse1CTD_human
HgeneAPOL2C0024809Marijuana Abuse1CTD_human
HgeneAPOL2C0031391Phencyclidine Abuse1CTD_human
HgeneAPOL2C0236735Cannabis-Related Disorder1CTD_human
HgeneAPOL2C0236736Cocaine-Related Disorders1CTD_human
HgeneAPOL2C0236742Phencyclidine-Related Disorders1CTD_human
HgeneAPOL2C0600427Cocaine Dependence1CTD_human
TgeneC0345967Malignant mesothelioma1CTD_human