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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ABCF1-SHC2 (FusionGDB2 ID:HG23TG25759)

Fusion Gene Summary for ABCF1-SHC2

check button Fusion gene summary
Fusion gene informationFusion gene name: ABCF1-SHC2
Fusion gene ID: hg23tg25759
HgeneTgene
Gene symbol

ABCF1

SHC2

Gene ID

23

25759

Gene nameATP binding cassette subfamily F member 1SHC adaptor protein 2
SynonymsABC27|ABC50SCK|SHCB|SLI
Cytomap('ABCF1')('SHC2')

6p21.33

19p13.3

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family F member 1ATP-binding cassette 50 (TNF-alpha stimulated)ATP-binding cassette, sub-family F (GCN20), member 1TNF-alpha-stimulated ABC proteinTNFalpha-inducible ATP-binding proteinSHC-transforming protein 2SH2 domain protein C2SHC (Src homology 2 domain containing) transforming protein 2SHC-transforming protein Bneuronal Shc adaptor homologprotein Scksrc homology 2 domain-containing-transforming protein C2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000326195, ENST00000376545, 
ENST00000383587, ENST00000383588, 
ENST00000396515, ENST00000400609, 
ENST00000412443, ENST00000416932, 
ENST00000419893, ENST00000420257, 
ENST00000421042, ENST00000421608, 
ENST00000423247, ENST00000426219, 
ENST00000448939, ENST00000452530, 
ENST00000454094, ENST00000456791, 
ENST00000457078, ENST00000457111, 
ENST00000457970, ENST00000470464, 
ENST00000475528, ENST00000485585, 
ENST00000486105, ENST00000494413, 
ENST00000495194, ENST00000546690, 
ENST00000552867, 
Fusion gene scores* DoF score6 X 5 X 4=1207 X 4 X 7=196
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ABCF1 [Title/Abstract] AND SHC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointABCF1(30554488)-SHC2(440932), # samples:2
Anticipated loss of major functional domain due to fusion event.ABCF1-SHC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF1-SHC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF1-SHC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCF1-SHC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ABCF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SHC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A7CF-01AABCF1chr6

30554488

-SHC2chr19

440932

-
ChimerDB4LGGTCGA-TM-A7CF-01AABCF1chr6

30554488

+SHC2chr19

440932

-


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Fusion Gene ORF analysis for ABCF1-SHC2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000326195ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
In-frameENST00000376545ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000383587ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000383588ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000396515ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000400609ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000412443ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000416932ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000419893ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000420257ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000421042ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000421608ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000423247ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000426219ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000448939ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000452530ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000454094ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000456791ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000457078ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000457111ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000457970ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000470464ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000475528ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000485585ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000486105ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000494413ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000495194ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000546690ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-
intron-3CDSENST00000552867ENST00000264554ABCF1chr6

30554488

+SHC2chr19

440932

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326195ABCF1chr630554488+ENST00000264554SHC2chr19440932-416921432534231132
ENST00000376545ABCF1chr630554488+ENST00000264554SHC2chr19440932-40382012832921094

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326195ENST00000264554ABCF1chr630554488+SHC2chr19440932-0.0059187010.9940813
ENST00000376545ENST00000264554ABCF1chr630554488+SHC2chr19440932-0.008104280.99189574

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Fusion Genomic Features for ABCF1-SHC2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ABCF1-SHC2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:30554488/chr19:440932)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCF1chr6:30554488chr19:440932ENST00000326195+2025141_243677846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000376545+1924141_243639808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000326195+2025304_548677846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000376545+1924304_548639808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000326195+2025336_343677846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000326195+2025658_665677846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000376545+1924336_343639808.0Nucleotide bindingATP 1
TgeneSHC2chr6:30554488chr19:440932ENST00000264554013487_578156694.6666666666666DomainSH2
TgeneSHC2chr6:30554488chr19:440932ENST00000264554013330_486156694.6666666666666RegionNote=CH1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCF1chr6:30554488chr19:440932ENST00000383587+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000383588+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000412443+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000419893+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000420257+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000421042+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000423247+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000426219+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000448939+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000452530+124141_2430808.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000457078+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000457111+125141_2430846.0Compositional biasNote=Glu-rich
HgeneABCF1chr6:30554488chr19:440932ENST00000326195+2025625_840677846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000376545+1924625_840639808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000383587+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000383587+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000383588+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000383588+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000412443+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000412443+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000419893+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000419893+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000420257+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000420257+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000421042+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000421042+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000423247+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000423247+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000426219+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000426219+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000448939+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000448939+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000452530+124304_5480808.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000452530+124625_8400808.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000457078+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000457078+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000457111+125304_5480846.0DomainABC transporter 1
HgeneABCF1chr6:30554488chr19:440932ENST00000457111+125625_8400846.0DomainABC transporter 2
HgeneABCF1chr6:30554488chr19:440932ENST00000376545+1924658_665639808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000383587+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000383587+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000383588+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000383588+125658_6650846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000412443+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000412443+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000419893+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000419893+125658_6650846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000420257+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000420257+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000421042+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000421042+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000423247+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000423247+125658_6650846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000426219+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000426219+125658_6650846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000448939+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000448939+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000452530+124336_3430808.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000452530+124658_6650808.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000457078+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000457078+125658_6650846.0Nucleotide bindingATP 2
HgeneABCF1chr6:30554488chr19:440932ENST00000457111+125336_3430846.0Nucleotide bindingATP 1
HgeneABCF1chr6:30554488chr19:440932ENST00000457111+125658_6650846.0Nucleotide bindingATP 2
TgeneSHC2chr6:30554488chr19:440932ENST00000264554013147_329156694.6666666666666DomainPID


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Fusion Gene Sequence for ABCF1-SHC2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>343_343_1_ABCF1-SHC2_ABCF1_chr6_30554488_ENST00000326195_SHC2_chr19_440932_ENST00000264554_length(transcript)=4169nt_BP=2143nt
CGGGGGCGGGGTTGGCCGCGCCAGCTTGGAGAGCCAGCCCCATCGGGGTTCCCCGCCGCCGGAAGCGGAAATAGCACCGGGCGCCGCCAC
AGTAGCTGTAACTGCCACCGCGATGCCGAAGGCGCCCAAGCAGCAGCCGCCGGAGCCCGAGTGGATCGGGGACGGAGAGAGCACGAGCCC
ATCAGACAAAGTGGTGAAGAAAGGGAAGAAGGACAAGAAGATCAAAAAAACGTTCTTTGAAGAGCTGGCAGTAGAAGATAAACAGGCTGG
GGAAGAAGAGAAAGTGCTCAAGGAGAAGGAGCAGCAGCAGCAGCAACAGCAACAGCAGCAAAAAAAAAAGCGAGATACCCGAAAAGGCAG
GCGGAAGAAGGATGTGGATGATGATGGAGAAGAGAAAGAGCTCATGGAGCGTCTTAAGAAGCTCTCAGTGCCAACCAGTGATGAGGAGGA
TGAAGTACCCGCCCCAAAACCCCGCGGAGGGAAGAAAACCAAGGGTGGTAATGTTTTTGCAGCCCTGATTCAGGATCAGAGTGAGGAAGA
GGAGGAGGAAGAAAAACATCCTCCTAAGCCTGCCAAGCCGGAGAAGAATCGGATCAATAAGGCCGTATCTGAGGAACAGCAGCCTGCACT
CAAGGGCAAAAAGGGAAAGGAAGAGAAGTCAAAAGGGAAGGCTAAGCCTCAAAATAAATTCGCTGCTCTGGACAATGAAGAGGAGGATAA
AGAAGAAGAAATTATAAAGGAAAAGGAGCCTCCCAAACAAGGGAAGGAGAAGGCCAAGAAGGCAGAGCAGGGTTCAGAGGAAGAAGGAGA
AGGGGAAGAAGAGGAGGAGGAAGGAGGAGAGTCTAAGGCAGATGATCCCTATGCTCATCTTAGCAAAAAGGAGAAGAAAAAGCTGAAAAA
ACAGATGGAGTATGAGCGCCAAGTGGCTTCATTAAAAGCAGCCAATGCAGCTGAAAATGACTTCTCCGTGTCCCAGGCGGAGATGTCCTC
CCGCCAAGCCATGTTAGAAAATGCATCTGACATCAAGCTGGAGAAGTTCAGCATCTCCGCTCATGGCAAGGAGCTGTTCGTCAATGCAGA
CCTGTACATTGTAGCCGGCCGCCGCTACGGGCTGGTAGGACCCAATGGCAAGGGCAAGACCACACTCCTCAAGCACATTGCCAACCGAGC
CCTGAGCATCCCTCCCAACATTGATGTGTTGCTGTGTGAGCAGGAGGTGGTAGCAGATGAGACACCAGCAGTCCAGGCTGTTCTTCGAGC
TGACACCAAGCGATTGAAGCTGCTGGAAGAGGAGCGGCGGCTTCAGGGACAGCTGGAACAAGGGGATGACACAGCTGCTGAGAGGCTAGA
GAAGGTGTATGAGGAATTGCGGGCCACTGGGGCGGCAGCTGCAGAGGCCAAAGCACGGCGGATCCTGGCTGGCCTGGGCTTTGACCCTGA
AATGCAGAATCGACCCACACAGAAGTTCTCAGGGGGCTGGCGCATGCGTGTCTCCCTGGCCAGGGCACTGTTCATGGAGCCCACACTGCT
GATGCTGGATGAGCCCACCAACCACCTGGACCTCAACGCTGTCATCTGGCTTAATAACTACCTCCAGGGCTGGCGGAAGACCTTGCTGAT
CGTCTCCCATGACCAGGGCTTCTTGGATGATGTCTGCACTGATATCATCCACCTCGATGCCCAGCGGCTCCACTACTATAGGGGCAATTA
CATGACCTTCAAAAAGATGTACCAGCAGAAGCAGAAAGAACTGCTGAAACAGTATGAGAAGCAAGAGAAAAAGCTGAAGGAGCTGAAGGC
AGGCGGGAAGTCCACCAAGCAGGCGGAAAAACAAACGAAGGAAGCCCTGACTCGGAAGCAGCAGAAATGCCGACGGAAAAACCAAGATGA
GGAATCCCAGGAGGCCCCTGAGCTCCTGAAGCGCCCTAAGGAGTACACTGTGCGCTTCACTTTTCCAGACCCCCCACCACTCAGCCCTCC
AGTGCTGGGTCTGCATGGTGTGACATTCGGCTACCAGGGACAGAAACCACTCTTTAAGAACTTGGATTTTGGCATCGACATGGATTCAAG
GATTTGCATTGTGGGCCCTAATGGTGTGGGGAAGAGTACGCTACTCCTGCTGCTGACTGGCAAGCTGACACCGTACATGGGCTGCATCGA
GGTTCTCCGCTCTATGCGCTCCCTGGACTTTAACACGCGCACGCAGGTGACCAGGGAAGCCATCAACCGGCTCCATGAGGCCGTGCCTGG
CGTCCGGGGATCCTGGAAGAAAAAGGCCCCCAACAAGGCCCTGGCGTCCGTCCTGGGCAAGAGCAACCTTCGCTTTGCCGGCATGAGCAT
CTCCATCCACATCTCCACTGATGGCCTCAGCCTCTCCGTGCCTGCCACGCGCCAGGTCATCGCCAACCACCACATGCCGTCCATCTCCTT
CGCGTCAGGCGGAGACACGGACATGACGGATTACGTGGCCTACGTCGCCAAGGACCCCATCAACCAGAGAGCCTGCCACATCCTGGAGTG
CTGTGAGGGCCTGGCACAGAGCATCATCAGCACCGTGGGCCAAGCTTTCGAGCTGCGCTTCAAGCAGTACCTGCACAGCCCGCCCAAGGT
GGCGCTGCCCCCAGAAAGGCTGGCAGGGCCGGAGGAGTCGGCCTGGGGGGACGAGGAGGACTCTTTGGAGCACAATTACTACAACAGCAT
CCCGGGGAAGGAGCCGCCGCTGGGCGGGCTAGTGGACTCCAGGCTGGCCCTGACACAGCCCTGCGCCCTCACGGCCCTCGACCAGGGCCC
ATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCCACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGA
CGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCAACACCCAGGGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGA
TCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGCATGAGTGCTCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGA
GGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGGCCCCCACGGAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGAT
GAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGGACTTCCTTGTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCAC
CGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGGACCCCGAGGGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAG
CCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCGTGGCCGCCGAGAGTGAGCTGCACCTGCGTGGCGTGGTCTCACGGGAGCC
CTGAGCCAGGTGACCGTTCTCAGCCCTGGCTCCTGCCTGTTCTCAGCCCCGGCTCCTGCCTGTCATGGCCTTGGGGCTCTCAGCCCTCCT
CCTGGATCCTGGTCAGGCCGAACCACCGCTGCCTCTCCTTCCTCCGCATGAGCCTCTGGCATGGTCCTTCCTCCAGCTGGCCCCGGGCTG
GGCAGAGCCTCCTCCTGCCGGGGCCCCTGCCCACCCCCTCCTTTGCCTGGAGTGAGGGTGTTCATACCAAAGACGGAACCATTTCGCCTT
TAAAGAAAATATATCCAGAAGCAGCCGCTGCCTCGGAGCCCTGGCCCTTGGGTCCCCCTCTCGCCTGGCTGGTTCGGTCTAACGCCCCGG
AGAGTCAGGGCTCCCAGGACCCTGGGGAGGAGGCGGATTCCGGGCCTGGCTGGGCTTCCTCTTCCCACCTGAGGACTGGGTGCACAGTTG
TCTTTGAGGGGGGACGCTTAAGGTGCTTTGGGGTTCTCAGGCCAGGATACATGCTGGCGCTGAAGTGCAGGCAGCCTTGAGGTCACCTGG
GATCTCGGGGTAGCCAGGCTGCTCCAAGACAGTGGATATCGAGGCAGTCGTGAGGCCCCTACTCCACCTGGGAGCAGGGGAAGGACGTGG
TTGCCTGGCCTGGGCTGCGCCCAGCAGCTTCCCCCCAGTCCTGCCCTCCCAGCTGTCGACCCAGATGGGATGTTCGGATCGGTTTGTAAT

>343_343_1_ABCF1-SHC2_ABCF1_chr6_30554488_ENST00000326195_SHC2_chr19_440932_ENST00000264554_length(amino acids)=1132AA_BP=706
MESQPHRGSPPPEAEIAPGAATVAVTATAMPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE
KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPP
KPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEG
GESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRR
YGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRA
TGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFL
DDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPEL
LKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPYMGCIEVLRSMRSL
DFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDM
TDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLG
GLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFE
DALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPK

--------------------------------------------------------------
>343_343_2_ABCF1-SHC2_ABCF1_chr6_30554488_ENST00000376545_SHC2_chr19_440932_ENST00000264554_length(transcript)=4038nt_BP=2012nt
GCGCCAGCTTGGAGAGCCAGCCCCATCGGGGTTCCCCGCCGCCGGAAGCGGAAATAGCACCGGGCGCCGCCACAGTAGCTGTAACTGCCA
CCGCGATGCCGAAGGCGCCCAAGCAGCAGCCGCCGGAGCCCGAGTGGATCGGGGACGGAGAGAGCACGAGCCCATCAGACAAAGTGGTGA
AGAAAGGGAAGAAGGACAAGAAGATCAAAAAAACGTTCTTTGAAGAGCTGGCAGTAGAAGATAAACAGGCTGGGGAAGAAGAGAAAGTGC
TCAAGGAGAAGGAGCAGCAGCAGCAGCAACAGCAACAGCAGCAAAAAAAAAAGCGAGATACCCGAAAAGGCAGGCGGAAGAAGGATGTGG
ATGATGATGGAGAAGAGAAAGAGCTCATGGAGCGTCTTAAGAAGCTCTCAGTGCCAACCAGTGATGAGGAGGATGAAGTACCCGCCCCAA
AACCCCGCGGAGGGAAGAAAACCAAGGGTGGTAATGTTTTTGCAGCCCTGATTCAGGATCAGAGTGAGGAAGAGGAGGAGGAAGAAAAAC
ATCCTCCTAAGCCTGCCAAGCCGGAGAAGAATCGGATCAATAAGGCCGTATCTGAGGAACAGCAGCCTGCACTCAAGGGCAAAAAGGGAA
AGGAAGAGAAGTCAAAAGGGAAGGCTAAGCCTCAAAATAAATTCGCTGCTCTGGACAATGAAGAGGAGGATAAAGAAGAAGAAATTATAA
AGGAAAAGGAGCCTCCCAAACAAGGGAAGGAGAAGGCCAAGAAGGCAGAGCAGATGGAGTATGAGCGCCAAGTGGCTTCATTAAAAGCAG
CCAATGCAGCTGAAAATGACTTCTCCGTGTCCCAGGCGGAGATGTCCTCCCGCCAAGCCATGTTAGAAAATGCATCTGACATCAAGCTGG
AGAAGTTCAGCATCTCCGCTCATGGCAAGGAGCTGTTCGTCAATGCAGACCTGTACATTGTAGCCGGCCGCCGCTACGGGCTGGTAGGAC
CCAATGGCAAGGGCAAGACCACACTCCTCAAGCACATTGCCAACCGAGCCCTGAGCATCCCTCCCAACATTGATGTGTTGCTGTGTGAGC
AGGAGGTGGTAGCAGATGAGACACCAGCAGTCCAGGCTGTTCTTCGAGCTGACACCAAGCGATTGAAGCTGCTGGAAGAGGAGCGGCGGC
TTCAGGGACAGCTGGAACAAGGGGATGACACAGCTGCTGAGAGGCTAGAGAAGGTGTATGAGGAATTGCGGGCCACTGGGGCGGCAGCTG
CAGAGGCCAAAGCACGGCGGATCCTGGCTGGCCTGGGCTTTGACCCTGAAATGCAGAATCGACCCACACAGAAGTTCTCAGGGGGCTGGC
GCATGCGTGTCTCCCTGGCCAGGGCACTGTTCATGGAGCCCACACTGCTGATGCTGGATGAGCCCACCAACCACCTGGACCTCAACGCTG
TCATCTGGCTTAATAACTACCTCCAGGGCTGGCGGAAGACCTTGCTGATCGTCTCCCATGACCAGGGCTTCTTGGATGATGTCTGCACTG
ATATCATCCACCTCGATGCCCAGCGGCTCCACTACTATAGGGGCAATTACATGACCTTCAAAAAGATGTACCAGCAGAAGCAGAAAGAAC
TGCTGAAACAGTATGAGAAGCAAGAGAAAAAGCTGAAGGAGCTGAAGGCAGGCGGGAAGTCCACCAAGCAGGCGGAAAAACAAACGAAGG
AAGCCCTGACTCGGAAGCAGCAGAAATGCCGACGGAAAAACCAAGATGAGGAATCCCAGGAGGCCCCTGAGCTCCTGAAGCGCCCTAAGG
AGTACACTGTGCGCTTCACTTTTCCAGACCCCCCACCACTCAGCCCTCCAGTGCTGGGTCTGCATGGTGTGACATTCGGCTACCAGGGAC
AGAAACCACTCTTTAAGAACTTGGATTTTGGCATCGACATGGATTCAAGGATTTGCATTGTGGGCCCTAATGGTGTGGGGAAGAGTACGC
TACTCCTGCTGCTGACTGGCAAGCTGACACCGTACATGGGCTGCATCGAGGTTCTCCGCTCTATGCGCTCCCTGGACTTTAACACGCGCA
CGCAGGTGACCAGGGAAGCCATCAACCGGCTCCATGAGGCCGTGCCTGGCGTCCGGGGATCCTGGAAGAAAAAGGCCCCCAACAAGGCCC
TGGCGTCCGTCCTGGGCAAGAGCAACCTTCGCTTTGCCGGCATGAGCATCTCCATCCACATCTCCACTGATGGCCTCAGCCTCTCCGTGC
CTGCCACGCGCCAGGTCATCGCCAACCACCACATGCCGTCCATCTCCTTCGCGTCAGGCGGAGACACGGACATGACGGATTACGTGGCCT
ACGTCGCCAAGGACCCCATCAACCAGAGAGCCTGCCACATCCTGGAGTGCTGTGAGGGCCTGGCACAGAGCATCATCAGCACCGTGGGCC
AAGCTTTCGAGCTGCGCTTCAAGCAGTACCTGCACAGCCCGCCCAAGGTGGCGCTGCCCCCAGAAAGGCTGGCAGGGCCGGAGGAGTCGG
CCTGGGGGGACGAGGAGGACTCTTTGGAGCACAATTACTACAACAGCATCCCGGGGAAGGAGCCGCCGCTGGGCGGGCTAGTGGACTCCA
GGCTGGCCCTGACACAGCCCTGCGCCCTCACGGCCCTCGACCAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACG
TGGGGTCCACCGGTACAGCTCCACCGGGGGACGGCTACGTGCAGGCGGACGCCCGGGGCCCCCCGGACCACGAGGAGCACCTGTATGTCA
ACACCCAGGGTCTGGACGCCCCCGAGCCGGAGGACAGCCCCAAAAAGGATCTGTTTGACATGCGACCCTTTGAGGATGCCCTGAAGTTGC
ATGAGTGCTCAGTGGCGGCAGGCGTGACAGCAGCCCCTCTTCCCTTGGAGGACCAGTGGCCCAGCCCCCCTACCCGCCGGGCCCCTGTGG
CCCCCACGGAGGAACAGCTGCGTCAGGAGCCCTGGTACCACGGCCGGATGAGCCGCCGGGCGGCAGAGAGGATGCTTCGAGCTGACGGGG
ACTTCCTTGTGCGAGACAGCGTCACCAACCCCGGGCAGTATGTCCTCACCGGCATGCACGCCGGGCAGCCCAAGCACCTGCTGCTCGTGG
ACCCCGAGGGCGTGGTACGGACGAAGGACGTGCTGTTTGAGAGCATCAGCCACCTGATCGACCACCACCTGCAGAACGGGCAGCCCATCG
TGGCCGCCGAGAGTGAGCTGCACCTGCGTGGCGTGGTCTCACGGGAGCCCTGAGCCAGGTGACCGTTCTCAGCCCTGGCTCCTGCCTGTT
CTCAGCCCCGGCTCCTGCCTGTCATGGCCTTGGGGCTCTCAGCCCTCCTCCTGGATCCTGGTCAGGCCGAACCACCGCTGCCTCTCCTTC
CTCCGCATGAGCCTCTGGCATGGTCCTTCCTCCAGCTGGCCCCGGGCTGGGCAGAGCCTCCTCCTGCCGGGGCCCCTGCCCACCCCCTCC
TTTGCCTGGAGTGAGGGTGTTCATACCAAAGACGGAACCATTTCGCCTTTAAAGAAAATATATCCAGAAGCAGCCGCTGCCTCGGAGCCC
TGGCCCTTGGGTCCCCCTCTCGCCTGGCTGGTTCGGTCTAACGCCCCGGAGAGTCAGGGCTCCCAGGACCCTGGGGAGGAGGCGGATTCC
GGGCCTGGCTGGGCTTCCTCTTCCCACCTGAGGACTGGGTGCACAGTTGTCTTTGAGGGGGGACGCTTAAGGTGCTTTGGGGTTCTCAGG
CCAGGATACATGCTGGCGCTGAAGTGCAGGCAGCCTTGAGGTCACCTGGGATCTCGGGGTAGCCAGGCTGCTCCAAGACAGTGGATATCG
AGGCAGTCGTGAGGCCCCTACTCCACCTGGGAGCAGGGGAAGGACGTGGTTGCCTGGCCTGGGCTGCGCCCAGCAGCTTCCCCCCAGTCC

>343_343_2_ABCF1-SHC2_ABCF1_chr6_30554488_ENST00000376545_SHC2_chr19_440932_ENST00000264554_length(amino acids)=1094AA_BP=668
MESQPHRGSPPPEAEIAPGAATVAVTATAMPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKE
KEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPP
KPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQMEYERQVASLKAANA
AENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEV
VADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMR
VSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLK
QYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKP
LFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAPNKALAS
VLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAF
ELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALTQPCALTALDQGPSPSLRDACSLPWDVGS
TGTAPPGDGYVQADARGPPDHEEHLYVNTQGLDAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPT
EEQLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ABCF1-SHC2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ABCF1-SHC2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ABCF1-SHC2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABCF1C0020517Hypersensitivity1CTD_human
HgeneABCF1C0032285Pneumonia1CTD_human
HgeneABCF1C0032300Lobar Pneumonia1CTD_human
HgeneABCF1C0235874Disease Exacerbation1CTD_human
HgeneABCF1C0887898Experimental Lung Inflammation1CTD_human
HgeneABCF1C1527304Allergic Reaction1CTD_human
HgeneABCF1C3714636Pneumonitis1CTD_human