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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AKR7L-CAPZB (FusionGDB2 ID:HG246181TG832)

Fusion Gene Summary for AKR7L-CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: AKR7L-CAPZB
Fusion gene ID: hg246181tg832
HgeneTgene
Gene symbol

AKR7L

CAPZB

Gene ID

246181

832

Gene namealdo-keto reductase family 7 like (gene/pseudogene)capping actin protein of muscle Z-line subunit beta
SynonymsAFAR3|AFB1-AR 3|AFB1-AR3|AKR7A4CAPB|CAPPB|CAPZ
Cytomap('AKR7L')('CAPZB')

1p36.13|1p35-p36.1

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionaflatoxin B1 aldehyde reductase member 4AFB1 aldehyde reductase 3aldo-keto reductase family 7 pseudogenealdo-keto reductase family 7-likealdoketoreductase 7-likeF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020031320200320
UniProtAcc.

P47756

Ensembl transtripts involved in fusion geneENST00000420396, ENST00000429712, 
Fusion gene scores* DoF score3 X 2 X 3=1823 X 15 X 8=2760
# samples 327
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AKR7L [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAKR7L(19595065)-CAPZB(19746244), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across AKR7L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JMAKR7Lchr1

19595065

-CAPZBchr1

19746244

-


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Fusion Gene ORF analysis for AKR7L-CAPZB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000420396ENST00000375144AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
5CDS-5UTRENST00000420396ENST00000482808AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
5CDS-5UTRENST00000429712ENST00000375144AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
5CDS-5UTRENST00000429712ENST00000482808AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000420396ENST00000264202AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000420396ENST00000264203AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000420396ENST00000375142AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000420396ENST00000401084AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000420396ENST00000433834AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000429712ENST00000264202AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000429712ENST00000264203AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000429712ENST00000375142AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000429712ENST00000401084AKR7Lchr1

19595065

-CAPZBchr1

19746244

-
In-frameENST00000429712ENST00000433834AKR7Lchr1

19595065

-CAPZBchr1

19746244

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000420396AKR7Lchr119595065-ENST00000401084CAPZBchr119746244-22106373371452371
ENST00000420396AKR7Lchr119595065-ENST00000264203CAPZBchr119746244-21306373371338333
ENST00000420396AKR7Lchr119595065-ENST00000375142CAPZBchr119746244-22736373371467376
ENST00000420396AKR7Lchr119595065-ENST00000433834CAPZBchr119746244-16246373371452371
ENST00000420396AKR7Lchr119595065-ENST00000264202CAPZBchr119746244-14686373371467377
ENST00000429712AKR7Lchr119595065-ENST00000401084CAPZBchr119746244-25279544921769425
ENST00000429712AKR7Lchr119595065-ENST00000264203CAPZBchr119746244-24479544921655387
ENST00000429712AKR7Lchr119595065-ENST00000375142CAPZBchr119746244-25909544921784430
ENST00000429712AKR7Lchr119595065-ENST00000433834CAPZBchr119746244-19419544921769425
ENST00000429712AKR7Lchr119595065-ENST00000264202CAPZBchr119746244-17859544921784430

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000420396ENST00000401084AKR7Lchr119595065-CAPZBchr119746244-0.0120248320.9879752
ENST00000420396ENST00000264203AKR7Lchr119595065-CAPZBchr119746244-0.042837520.95716244
ENST00000420396ENST00000375142AKR7Lchr119595065-CAPZBchr119746244-0.0149190850.9850809
ENST00000420396ENST00000433834AKR7Lchr119595065-CAPZBchr119746244-0.0278486630.9721513
ENST00000420396ENST00000264202AKR7Lchr119595065-CAPZBchr119746244-0.0265832820.9734167
ENST00000429712ENST00000401084AKR7Lchr119595065-CAPZBchr119746244-0.0038699420.99613
ENST00000429712ENST00000264203AKR7Lchr119595065-CAPZBchr119746244-0.0049050520.995095
ENST00000429712ENST00000375142AKR7Lchr119595065-CAPZBchr119746244-0.0045572140.99544275
ENST00000429712ENST00000433834AKR7Lchr119595065-CAPZBchr119746244-0.0095831310.9904169
ENST00000429712ENST00000264202AKR7Lchr119595065-CAPZBchr119746244-0.0086525590.9913475

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Fusion Genomic Features for AKR7L-CAPZB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AKR7L-CAPZB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:19595065/chr1:19746244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPZB

P47756

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKR7Lchr1:19595065chr1:19746244ENST00000420396-45143_144100154.0Nucleotide bindingNADP
HgeneAKR7Lchr1:19595065chr1:19746244ENST00000420396-45198_208100154.0Nucleotide bindingNADP
HgeneAKR7Lchr1:19595065chr1:19746244ENST00000420396-45290_298100154.0Nucleotide bindingNADP


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Fusion Gene Sequence for AKR7L-CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>3459_3459_1_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000264202_length(transcript)=1468nt_BP=637nt
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGCA
GTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCATGGATTGGGAACTCCCTGAAGCCTGACAGT
GTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGCCTGGGAAGTG
GCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGCTTCTGGAAGGAGCACCACTTCGAGGGCATTGC
CCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCTCCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACA
GCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGAT
CGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTA
CCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCC
GTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGT
CTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGA
TTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGAC
CAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACA
CATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATAT
CGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCG
CCAGATCTACATCCAGCCTGATAATTAA

>3459_3459_1_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=377AA_BP=99
MHLTTAPRWKRHCVPATSCTRRASSWSLASPTMPPGKWPRSVPSARATAGSCPLCTSFWKEHHFEGIALVEKALQAAYGASAPSMTSAAL
RWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDP
PLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRE
LSQVLTQRQIYIQPDNX

--------------------------------------------------------------
>3459_3459_2_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000264203_length(transcript)=2130nt_BP=637nt
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGCA
GTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCATGGATTGGGAACTCCCTGAAGCCTGACAGT
GTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGCCTGGGAAGTG
GCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGCTTCTGGAAGGAGCACCACTTCGAGGGCATTGC
CCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCTCCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACA
GCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGAT
CGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTA
CCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCC
GTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGT
CTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGA
TTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGAC
CAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACA
CATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGG
CTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGT
TTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAAT
AAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGG
TTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCAC
CTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATC
TTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTC
CTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTT
CTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGA
GCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGGCGCAGTT

>3459_3459_2_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=333AA_BP=99
MHLTTAPRWKRHCVPATSCTRRASSWSLASPTMPPGKWPRSVPSARATAGSCPLCTSFWKEHHFEGIALVEKALQAAYGASAPSMTSAAL
RWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDP
PLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEVCADFCRQIKTRSSEE

--------------------------------------------------------------
>3459_3459_3_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000375142_length(transcript)=2273nt_BP=637nt
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGCA
GTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCATGGATTGGGAACTCCCTGAAGCCTGACAGT
GTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGCCTGGGAAGTG
GCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGCTTCTGGAAGGAGCACCACTTCGAGGGCATTGC
CCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCTCCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACA
GCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGAT
CGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTA
CCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCC
GTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGT
CTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGA
TTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGAC
CAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACA
CATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATAT
CGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAGTTTAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCG
CCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGAC
CTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTA
GAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCT
CCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGA
GACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCT
TCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAA
ACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCT
CGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCC
AGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATC
TTATACTTGAGCCTCCATACTTA

>3459_3459_3_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=376AA_BP=99
MHLTTAPRWKRHCVPATSCTRRASSWSLASPTMPPGKWPRSVPSARATAGSCPLCTSFWKEHHFEGIALVEKALQAAYGASAPSMTSAAL
RWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDP
PLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRE
LSQVLTQRQIYIQPDN

--------------------------------------------------------------
>3459_3459_4_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000401084_length(transcript)=2210nt_BP=637nt
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGCA
GTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCATGGATTGGGAACTCCCTGAAGCCTGACAGT
GTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGCCTGGGAAGTG
GCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGCTTCTGGAAGGAGCACCACTTCGAGGGCATTGC
CCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCTCCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACA
GCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGAT
CGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTA
CCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCC
GTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGT
CTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGA
TTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGAC
CAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACA
CATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATAT
CGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAA
GCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTT
CCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCC
ACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCC
GGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACAT
TGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGT
GTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCT
CCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTA
TGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTA
AAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGGCGCAGTTAGC

>3459_3459_4_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=371AA_BP=99
MHLTTAPRWKRHCVPATSCTRRASSWSLASPTMPPGKWPRSVPSARATAGSCPLCTSFWKEHHFEGIALVEKALQAAYGASAPSMTSAAL
RWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDP
PLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKND
LVEALKRKQQC

--------------------------------------------------------------
>3459_3459_5_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000433834_length(transcript)=1624nt_BP=637nt
ATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGGCGCCGCATGGACGCGCCCACCAGCGCCGCA
GTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGCGACGGCCAGTCCGAGACCATCCTTGGCGGC
CTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCATGGATTGGGAACTCCCTGAAGCCTGACAGT
GTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTCTATCTACATGCACCTGACCACAGCGCCCCG
GTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTTGGCCTCTCCAACTATGCCGCCTGGGAAGTG
GCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGCTTCTGGAAGGAGCACCACTTCGAGGGCATTGC
CCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCTCCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACA
GCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGAT
CGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTA
CCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCC
GTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGT
CTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGA
TTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGAC
CAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACA
CATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATAT
CGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAA
GCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTT
CCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCC
ACCC

>3459_3459_5_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000420396_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=371AA_BP=99
MHLTTAPRWKRHCVPATSCTRRASSWSLASPTMPPGKWPRSVPSARATAGSCPLCTSFWKEHHFEGIALVEKALQAAYGASAPSMTSAAL
RWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDP
PLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTS
TVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKND
LVEALKRKQQC

--------------------------------------------------------------
>3459_3459_6_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000264202_length(transcript)=1785nt_BP=954nt
ACCACCGGTGGGCGCGGCCCGAGCCAGTCCCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCT
GGGCTGTCACAGTCTCCCGTTGCCGCCGTCATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGC
GACGGCCAGTCCGAGACCATCCTTGGCGGCCTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTC
TATCTACATGCACCTGACCACAGCGCCCCGGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGC
ATGTACAGCGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCCGCTTCTTTGGGACTCAGTGGGCAGAG
ATCTACAGGAATCACTTCTGGAAGGAGCACCACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATG
AGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTT
GACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCA
CCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCC
TTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTC
ATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGC
ACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTT
ACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAA
ATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAA
AAGTTTAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAA

>3459_3459_6_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=430AA_BP=153
MRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK
DGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSD
LIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVS
SVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCS
PHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRELSQVLTQRQIYIQPDN

--------------------------------------------------------------
>3459_3459_7_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000264203_length(transcript)=2447nt_BP=954nt
ACCACCGGTGGGCGCGGCCCGAGCCAGTCCCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCT
GGGCTGTCACAGTCTCCCGTTGCCGCCGTCATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGC
GACGGCCAGTCCGAGACCATCCTTGGCGGCCTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTC
TATCTACATGCACCTGACCACAGCGCCCCGGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGC
ATGTACAGCGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCCGCTTCTTTGGGACTCAGTGGGCAGAG
ATCTACAGGAATCACTTCTGGAAGGAGCACCACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATG
AGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTT
GACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCA
CCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCC
TTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTC
ATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGC
ACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTT
ACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTT
TGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTA
ACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCAC
ATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGC
CACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCA
TTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTT
TATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGT
GGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGC
TGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATT
TTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAA
GAAACTGGGGCGCAGTT

>3459_3459_7_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=387AA_BP=153
MRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK
DGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSD
LIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVS
SVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCS
PHIANIGRLVEVCADFCRQIKTRSSEE

--------------------------------------------------------------
>3459_3459_8_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000375142_length(transcript)=2590nt_BP=954nt
ACCACCGGTGGGCGCGGCCCGAGCCAGTCCCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCT
GGGCTGTCACAGTCTCCCGTTGCCGCCGTCATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGC
GACGGCCAGTCCGAGACCATCCTTGGCGGCCTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTC
TATCTACATGCACCTGACCACAGCGCCCCGGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGC
ATGTACAGCGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCCGCTTCTTTGGGACTCAGTGGGCAGAG
ATCTACAGGAATCACTTCTGGAAGGAGCACCACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATG
AGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTT
GACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCA
CCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCC
TTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTC
ATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGC
ACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTT
ACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAA
ATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAA
AAGTTTAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTG
TGCAGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTG
TTTCATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCC
GACAGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGC
CTGCTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCC
TGTCCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAAC
AAAAAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGT
TGGGGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCG
GGGTGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTT
TTGTTTTATTTTGTTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTA

>3459_3459_8_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=430AA_BP=153
MRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK
DGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSD
LIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVS
SVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCS
PHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSIDAIPDNQKFKQLQRELSQVLTQRQIYIQPDN

--------------------------------------------------------------
>3459_3459_9_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000401084_length(transcript)=2527nt_BP=954nt
ACCACCGGTGGGCGCGGCCCGAGCCAGTCCCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCT
GGGCTGTCACAGTCTCCCGTTGCCGCCGTCATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGC
GACGGCCAGTCCGAGACCATCCTTGGCGGCCTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTC
TATCTACATGCACCTGACCACAGCGCCCCGGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGC
ATGTACAGCGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCCGCTTCTTTGGGACTCAGTGGGCAGAG
ATCTACAGGAATCACTTCTGGAAGGAGCACCACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATG
AGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTT
GACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCA
CCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCC
TTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTC
ATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGC
ACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTT
ACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAA
ATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCA
AAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCG
TGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCAT
CATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCT
CAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAA
AATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTG
TGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGAC
AGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCC
GCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTA
AAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGGCGC
AGTTAGC

>3459_3459_9_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=425AA_BP=153
MRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK
DGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSD
LIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVS
SVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCS
PHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC

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>3459_3459_10_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000433834_length(transcript)=1941nt_BP=954nt
ACCACCGGTGGGCGCGGCCCGAGCCAGTCCCTAAAGCCACGAGGCCGCCCGCTCCGAGCCTGGTGCTTCCGACCGCTGCGCGCGGCTCCT
GGGCTGTCACAGTCTCCCGTTGCCGCCGTCATGTCCCGGCAGCTGTCGCGGGCCCGGCCAGCCACGGTGCTGGGCGCCATGGAGATGGGG
CGCCGCATGGACGCGCCCACCAGCGCCGCAGTCACGCGCGCCTTCCTGGAGCGCGGCCACACCGAGATAGACACGGCCTTCCTGTACAGC
GACGGCCAGTCCGAGACCATCCTTGGCGGCCTGGGGCTCCGAATGGGCAGCAGCGACTGCAGAGTGAAAATTGCTACCAAGGCCAATCCA
TGGATTGGGAACTCCCTGAAGCCTGACAGTGTCCGATCCCAGCTGGAGACGTCACTGAAGCGGCTGCAGTGTCCCTGAGTGGACCTCTTC
TATCTACATGCACCTGACCACAGCGCCCCGGTGGAAGAGACACTGCGTGCCTGCCACCAGCTGCACCAGGAGGGCAAGTTCGTGGAGCTT
GGCCTCTCCAACTATGCCGCCTGGGAAGTGGCCGAGATCTGTACCCTCTGCAAGAGCAACGGCTGGATCCTGCCCACTGTGTACCAGGGC
ATGTACAGCGCCACCACCCGGCAGGTGGAAACGGAGCTCTTCCCCTGCCTCAGGCACTTTGGACTGAGGTTCTATGCCTACAACCCTCTG
GCTGGGGGCCTGCTGACCGGCAAGTACAAGTATGAGGACAAGGACGGGAAACAGCCCGTGGGCCGCTTCTTTGGGACTCAGTGGGCAGAG
ATCTACAGGAATCACTTCTGGAAGGAGCACCACTTCGAGGGCATTGCCCTGGTGGAGAAGGCCCTGCAGGCCGCGTATGGCGCCAGCGCT
CCCAGCATGACCTCGGCCGCCCTCCGGTGGATGTACCACCACTCACAGCTGCAGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATG
AGGCGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTT
GACCAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCA
CCATGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCC
TTTGACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTC
ATAAAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGC
ACCGCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTT
ACCAGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAA
ATCAGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCA
AAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCG
TGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCAT
CATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCC

>3459_3459_10_AKR7L-CAPZB_AKR7L_chr1_19595065_ENST00000429712_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=425AA_BP=153
MRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYSATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDK
DGKQPVGRFFGTQWAEIYRNHFWKEHHFEGIALVEKALQAAYGASAPSMTSAALRWMYHHSQLQSDQQLDCALDLMRRLPPQQIEKNLSD
LIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVS
SVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCS
PHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC

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Fusion Gene PPI Analysis for AKR7L-CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AKR7L-CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AKR7L-CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0007097Carcinoma1CTD_human
TgeneC0024667Animal Mammary Neoplasms1CTD_human
TgeneC0024668Mammary Neoplasms, Experimental1CTD_human
TgeneC0205696Anaplastic carcinoma1CTD_human
TgeneC0205697Carcinoma, Spindle-Cell1CTD_human
TgeneC0205698Undifferentiated carcinoma1CTD_human
TgeneC0205699Carcinomatosis1CTD_human
TgeneC0948089Acute Coronary Syndrome1CTD_human
TgeneC1257925Mammary Carcinoma, Animal1CTD_human