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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ALOX15-PSMD2 (FusionGDB2 ID:HG246TG5708)

Fusion Gene Summary for ALOX15-PSMD2

check button Fusion gene summary
Fusion gene informationFusion gene name: ALOX15-PSMD2
Fusion gene ID: hg246tg5708
HgeneTgene
Gene symbol

ALOX15

PSMD2

Gene ID

246

5708

Gene namearachidonate 15-lipoxygenaseproteasome 26S subunit, non-ATPase 2
Synonyms12-LOX|15-LOX|15-LOX-1|LOG15P97|RPN1|S2|TRAP2
Cytomap('ALOX15')('PSMD2')

17p13.2

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionarachidonate 15-lipoxygenase12/15-lipoxygenase15-LOX type 115-lipooxygenase-115-lipoxygenase type 1arachidonate 12-lipoxygenase, leukocyte-typearachidonate omega-6 lipoxygenase26S proteasome non-ATPase regulatory subunit 255.11 proteinTNFR-associated protein 2proteasome (prosome, macropain) 26S subunit, non-ATPase, 2protein 55.11tumor necrosis factor type 1 receptor-associated protein 2
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000293761, ENST00000545513, 
ENST00000570836, ENST00000574640, 
Fusion gene scores* DoF score2 X 2 X 2=87 X 8 X 3=168
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ALOX15 [Title/Abstract] AND PSMD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointALOX15(4539053)-PSMD2(184021734), # samples:1
Anticipated loss of major functional domain due to fusion event.ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ALOX15-PSMD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneALOX15

GO:0010811

positive regulation of cell-substrate adhesion

11278875

HgeneALOX15

GO:0019369

arachidonic acid metabolic process

1944593|17052953

HgeneALOX15

GO:0019372

lipoxygenase pathway

1944593

HgeneALOX15

GO:0071277

cellular response to calcium ion

17052953


check buttonFusion gene breakpoints across ALOX15 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PSMD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4THCATCGA-DJ-A2PZALOX15chr17

4539053

-PSMD2chr3

184021734

+


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Fusion Gene ORF analysis for ALOX15-PSMD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000293761ENST00000459910ALOX15chr17

4539053

-PSMD2chr3

184021734

+
5CDS-intronENST00000545513ENST00000459910ALOX15chr17

4539053

-PSMD2chr3

184021734

+
5CDS-intronENST00000570836ENST00000459910ALOX15chr17

4539053

-PSMD2chr3

184021734

+
5CDS-intronENST00000574640ENST00000459910ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000293761ENST00000310118ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000293761ENST00000435761ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000293761ENST00000439383ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000545513ENST00000310118ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000545513ENST00000435761ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000545513ENST00000439383ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000570836ENST00000310118ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000570836ENST00000435761ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000570836ENST00000439383ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000574640ENST00000310118ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000574640ENST00000435761ALOX15chr17

4539053

-PSMD2chr3

184021734

+
In-frameENST00000574640ENST00000439383ALOX15chr17

4539053

-PSMD2chr3

184021734

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000570836ALOX15chr174539053-ENST00000310118PSMD2chr3184021734+28261258312661876
ENST00000570836ALOX15chr174539053-ENST00000435761PSMD2chr3184021734+27721258312661876
ENST00000570836ALOX15chr174539053-ENST00000439383PSMD2chr3184021734+28201258312661876
ENST00000293761ALOX15chr174539053-ENST00000310118PSMD2chr3184021734+2743117552578857
ENST00000293761ALOX15chr174539053-ENST00000435761PSMD2chr3184021734+2689117552578857
ENST00000293761ALOX15chr174539053-ENST00000439383PSMD2chr3184021734+2737117552578857
ENST00000574640ALOX15chr174539053-ENST00000310118PSMD2chr3184021734+289613281642731855
ENST00000574640ALOX15chr174539053-ENST00000435761PSMD2chr3184021734+284213281642731855
ENST00000574640ALOX15chr174539053-ENST00000439383PSMD2chr3184021734+289013281642731855
ENST00000545513ALOX15chr174539053-ENST00000310118PSMD2chr3184021734+28261258312661876
ENST00000545513ALOX15chr174539053-ENST00000435761PSMD2chr3184021734+27721258312661876
ENST00000545513ALOX15chr174539053-ENST00000439383PSMD2chr3184021734+28201258312661876

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000570836ENST00000310118ALOX15chr174539053-PSMD2chr3184021734+0.0057654190.9942346
ENST00000570836ENST00000435761ALOX15chr174539053-PSMD2chr3184021734+0.0067711490.9932288
ENST00000570836ENST00000439383ALOX15chr174539053-PSMD2chr3184021734+0.0057973020.9942027
ENST00000293761ENST00000310118ALOX15chr174539053-PSMD2chr3184021734+0.0033011170.9966989
ENST00000293761ENST00000435761ALOX15chr174539053-PSMD2chr3184021734+0.0039143180.99608564
ENST00000293761ENST00000439383ALOX15chr174539053-PSMD2chr3184021734+0.003312580.9966875
ENST00000574640ENST00000310118ALOX15chr174539053-PSMD2chr3184021734+0.0068647550.9931352
ENST00000574640ENST00000435761ALOX15chr174539053-PSMD2chr3184021734+0.0076188780.99238116
ENST00000574640ENST00000439383ALOX15chr174539053-PSMD2chr3184021734+0.0068721170.99312794
ENST00000545513ENST00000310118ALOX15chr174539053-PSMD2chr3184021734+0.0057654190.9942346
ENST00000545513ENST00000435761ALOX15chr174539053-PSMD2chr3184021734+0.0067711490.9932288
ENST00000545513ENST00000439383ALOX15chr174539053-PSMD2chr3184021734+0.0057973020.9942027

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Fusion Genomic Features for ALOX15-PSMD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ALOX15chr174539053-PSMD2chr3184021734+0.999726360.000273681
ALOX15chr174539053-PSMD2chr3184021734+0.999726360.000273681

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ALOX15-PSMD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4539053/chr3:184021734)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALOX15chr17:4539053chr3:184021734ENST00000293761-8142_114387663.0DomainPLAT
HgeneALOX15chr17:4539053chr3:184021734ENST00000570836-9152_114387663.0DomainPLAT
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921623_641441909.0Compositional biasNote=Glu/Lys-rich
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921443_479441909.0RepeatNote=PC 2
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921480_514441909.0RepeatNote=PC 3
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921517_551441909.0RepeatNote=PC 4
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921560_589441909.0RepeatNote=PC 5
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921692_723441909.0RepeatNote=PC 6
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921742_757441909.0RepeatNote=PC 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneALOX15chr17:4539053chr3:184021734ENST00000293761-814115_662387663.0DomainLipoxygenase
HgeneALOX15chr17:4539053chr3:184021734ENST00000570836-915115_662387663.0DomainLipoxygenase
TgenePSMD2chr17:4539053chr3:184021734ENST00000310118921409_442441909.0RepeatNote=PC 1


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Fusion Gene Sequence for ALOX15-PSMD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4095_4095_1_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000310118_length(transcript)=2743nt_BP=1175nt
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGT
ATCTGGGGCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCC
CCGGAGCCGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTG
TGGGCGAGGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGG
ACGGGTTAATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGG
TTTCGCTGGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGA
TTTTCTGGTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCG
CCAACCCCGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGA
AGGAGCTGGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACC
TGGCTGCCCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCC
CACCACCTCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATG
AGCTGCAGTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCT
TCAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATG
TTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACAC
TGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCT
GCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTC
TTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTT
TTGCCAACACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACT
TTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATC
AGGGAGTGGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGA
GATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCC
TAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCC
GTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACAC
ATTTAGGGAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGC
TTGTCTCTTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGC
TGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGA
AGACTATCACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTG
TTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGA
TGTTATCAGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTG
AGTGAGATAAGGTTGTTCAATAAAGACTTTTATCCCCAAGGTC

>4095_4095_1_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT
ITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_2_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000435761_length(transcript)=2689nt_BP=1175nt
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGT
ATCTGGGGCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCC
CCGGAGCCGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTG
TGGGCGAGGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGG
ACGGGTTAATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGG
TTTCGCTGGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGA
TTTTCTGGTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCG
CCAACCCCGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGA
AGGAGCTGGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACC
TGGCTGCCCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCC
CACCACCTCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATG
AGCTGCAGTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCT
TCAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATG
TTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACAC
TGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCT
GCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTC
TTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTT
TTGCCAACACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACT
TTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATC
AGGGAGTGGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGA
GATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCC
TAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCC
GTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACAC
ATTTAGGGAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGC
TTGTCTCTTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGC
TGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGA
AGACTATCACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTG
TTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGA
TGTTATCAGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTC

>4095_4095_2_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT
ITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_3_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000439383_length(transcript)=2737nt_BP=1175nt
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGT
ATCTGGGGCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCC
CCGGAGCCGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTG
TGGGCGAGGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGG
ACGGGTTAATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGG
TTTCGCTGGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGA
TTTTCTGGTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCG
CCAACCCCGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGA
AGGAGCTGGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACC
TGGCTGCCCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCC
CACCACCTCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATG
AGCTGCAGTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCT
TCAAGTCAGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATG
TTCTCCACAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACAC
TGCTGCTGCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCT
GCAATGGAGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTC
TTGGACTGGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTT
TTGCCAACACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACT
TTGACTCCAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATC
AGGGAGTGGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGA
GATATGGGGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCC
TAAGCAAATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCC
GTCTGGCTGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACAC
ATTTAGGGAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGC
TTGTCTCTTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGC
TGGTTACGTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGA
AGACTATCACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTG
TTACCCCCATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGA
TGTTATCAGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTG
AGTGAGATAAGGTTGTTCAATAAAGACTTTTATCCCC

>4095_4095_3_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000293761_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=857AA_BP=390
MSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKRHLLKDDAWFCNWISVQGPG
AGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVS
LAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKE
LEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHEL
QSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLL
LPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFA
NTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRY
GEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHL
GKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKT
ITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_4_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000310118_length(transcript)=2826nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGA
TAAGGTTGTTCAATAAAGACTTTTATCCCCAAGGTC

>4095_4095_4_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_5_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000435761_length(transcript)=2772nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTC

>4095_4095_5_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_6_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000439383_length(transcript)=2820nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGA
TAAGGTTGTTCAATAAAGACTTTTATCCCC

>4095_4095_6_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000545513_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_7_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000310118_length(transcript)=2826nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGA
TAAGGTTGTTCAATAAAGACTTTTATCCCCAAGGTC

>4095_4095_7_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_8_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000435761_length(transcript)=2772nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTC

>4095_4095_8_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_9_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000439383_length(transcript)=2820nt_BP=1258nt
TTCTGCAGGCAACAGGGAGGCAGCGGCTTTTATGCTCAAAAGGAATGAGTCCCAGTGGCTGGCACAGAGAAGAAGGAGCGAAACATCTTT
GAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGCTGGTCGG
CCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGAGACAGAACTCAAGGTGGAAGTACCGGAGTATCTGGG
GCCGCTGCTGTTTGTGAAACTGCGCAAACGGCACCTCCTTAAGGACGACGCCTGGTTCTGCAACTGGATCTCTGTGCAGGGCCCCGGAGC
CGGGGACGAGGTCAGGTTCCCTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGA
GGACCCTCAGGGCCTGTTCCAGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTT
AATTCTGAATATGGCTGGGGCCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCT
GGCCAAGGGGCTGGCCGACCTCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTG
GTGTGGTCAGAGCAAGCTGGCTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCC
CGTGGTGCTGAGGCGCTCTGCTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCT
GGAGGGAGGCACACTGTTCGAAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGC
CCCTCTAGTCATGCTGAAATTGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACC
TCCCCTTTTCTTGCCTACGGATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCA
GTCTCATCTTCTGAGGGGACACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTC
AGGAGCTCTTCTTGCCTGTGGCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCA
CAACAGCAACACCATGAGACTTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCT
GCCTGTGATGGGAGATTCAAAGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGG
AGATGTAACTTCCACTATCCTTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACT
GGGTCTCAACCACCTGGGGAAGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAA
CACACTGGTGGATGTGTGTGCATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTC
CAAAGAGAAGGAGGAAGACAAAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGT
GGCTGTTCTGGGGATTGCCCTTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGG
GGAGCCTACACTCCGGAGGGCTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAA
ATTCTCTCATGATGCTGATCCAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGC
TGCAATGCTGCGCCAGTTAGCTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGG
GAAGGGCACCCTTACCCTCTGCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTC
TTTCCTGGATGTTCGAAACATTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTAC
GTTTGATGAGGAGCTGCGGCCATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTAT
CACAGGGTTCCAGACGCATACAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCC
CATTCTGGAAGGTTTTGTTATCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATC
AGCAGGCCATGCATCCTGCTGCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGA
TAAGGTTGTTCAATAAAGACTTTTATCCCC

>4095_4095_9_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000570836_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=876AA_BP=409
MLKRNESQWLAQRRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKETELKVEVPEYLGPLLFVKLRKR
HLLKDDAWFCNWISVQGPGAGDEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLY
DLPVDERFLEDKRVDFEVSLAKGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLP
ARLVFPPGMEELQAQLEKELEGGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPM
AWLLAKCWVRSSDFQLHELQSHLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSI
FGLGLAYAGSNREDVLTLLLPVMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEA
IEAILAALEVVSEPFRSFANTLVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAM
GEEIGAEMALRTFGHLLRYGEPTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYH
AKDPNNLFMVRLAQGLTHLGKGTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPV
SVRVGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_10_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000310118_length(transcript)=2896nt_BP=1328nt
CTGCGTGTTTTCGGTCCAAATCCTTTTCTTTTTCTCCCTCCCGTCAAGATAGTGGTTTCCACTCCCTGCTCTCGCCAGGACACCGCCTTT
TGGACTGGGGCTGAATTCTGCCCCTTGAAGCTCTGCTCCTTGGAGCTGGGGGCCCCAGCGGTAGGCGGAGTTGATTGGAGACCTGCCACC
CACATTCCGACCCCAAGCGACCTCCGAGAGGGCGGGGTCTCAGGCTGGGTTATTTAGCTCGTCCACCCTTCTCCACCAGAAGGAGCGAAA
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGGCCCCGGAGCCGGGGACGAGGTCAGGTTCC
CTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGAGGACCCTCAGGGCCTGTTCC
AGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTTAATTCTGAATATGGCTGGGG
CCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCTGGCCAAGGGGCTGGCCGACC
TCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTGGTGTGGTCAGAGCAAGCTGG
CTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCCCGTGGTGCTGAGGCGCTCTG
CTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCTGGAGGGAGGCACACTGTTCG
AAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGCCCCTCTAGTCATGCTGAAAT
TGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACCTCCCCTTTTCTTGCCTACGG
ATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCAGTCTCATCTTCTGAGGGGAC
ACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTCAGGAGCTCTTCTTGCCTGTG
GCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGAC
TTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAA
AGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCC
TTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGA
AGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTG
CATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACA
AAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCC
TTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGG
CTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATC
CAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAG
CTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCT
GCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACA
TTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGC
CATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATA
CAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTA
TCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCT
GCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGATAAGGTTGTTCAATAAAGAC
TTTTATCCCCAAGGTC

>4095_4095_10_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000310118_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT
GFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_11_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000435761_length(transcript)=2842nt_BP=1328nt
CTGCGTGTTTTCGGTCCAAATCCTTTTCTTTTTCTCCCTCCCGTCAAGATAGTGGTTTCCACTCCCTGCTCTCGCCAGGACACCGCCTTT
TGGACTGGGGCTGAATTCTGCCCCTTGAAGCTCTGCTCCTTGGAGCTGGGGGCCCCAGCGGTAGGCGGAGTTGATTGGAGACCTGCCACC
CACATTCCGACCCCAAGCGACCTCCGAGAGGGCGGGGTCTCAGGCTGGGTTATTTAGCTCGTCCACCCTTCTCCACCAGAAGGAGCGAAA
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGGCCCCGGAGCCGGGGACGAGGTCAGGTTCC
CTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGAGGACCCTCAGGGCCTGTTCC
AGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTTAATTCTGAATATGGCTGGGG
CCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCTGGCCAAGGGGCTGGCCGACC
TCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTGGTGTGGTCAGAGCAAGCTGG
CTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCCCGTGGTGCTGAGGCGCTCTG
CTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCTGGAGGGAGGCACACTGTTCG
AAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGCCCCTCTAGTCATGCTGAAAT
TGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACCTCCCCTTTTCTTGCCTACGG
ATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCAGTCTCATCTTCTGAGGGGAC
ACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTCAGGAGCTCTTCTTGCCTGTG
GCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGAC
TTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAA
AGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCC
TTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGA
AGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTG
CATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACA
AAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCC
TTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGG
CTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATC
CAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAG
CTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCT
GCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACA
TTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGC
CATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATA
CAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTA
TCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCT
GCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTC

>4095_4095_11_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000435761_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT
GFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------
>4095_4095_12_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000439383_length(transcript)=2890nt_BP=1328nt
CTGCGTGTTTTCGGTCCAAATCCTTTTCTTTTTCTCCCTCCCGTCAAGATAGTGGTTTCCACTCCCTGCTCTCGCCAGGACACCGCCTTT
TGGACTGGGGCTGAATTCTGCCCCTTGAAGCTCTGCTCCTTGGAGCTGGGGGCCCCAGCGGTAGGCGGAGTTGATTGGAGACCTGCCACC
CACATTCCGACCCCAAGCGACCTCCGAGAGGGCGGGGTCTCAGGCTGGGTTATTTAGCTCGTCCACCCTTCTCCACCAGAAGGAGCGAAA
CATCTTTGAGCAAGATGGGTCTCTACCGCATCCGCGTGTCCACTGGGGCCTCGCTCTATGCCGGTTCCAACAACCAGGTGCAGCTGTGGC
TGGTCGGCCAGCACGGGGAGGCGGCGCTCGGGAAGCGACTGTGGCCCGCACGGGGCAAGGGCCCCGGAGCCGGGGACGAGGTCAGGTTCC
CTTGTTACCGCTGGGTGGAGGGCAACGGCGTCCTGAGCCTGCCTGAAGGCACCGGCCGCACTGTGGGCGAGGACCCTCAGGGCCTGTTCC
AGAAACACCGGGAAGAAGAGCTGGAAGAGAGAAGGAAGTTGTACCGGTGGGGAAACTGGAAGGACGGGTTAATTCTGAATATGGCTGGGG
CCAAACTATATGACCTCCCTGTGGATGAGCGATTTCTGGAAGACAAGAGAGTTGACTTTGAGGTTTCGCTGGCCAAGGGGCTGGCCGACC
TCGCTATCAAAGACTCTCTAAATGTTCTGACTTGCTGGAAGGATCTAGATGACTTCAACCGGATTTTCTGGTGTGGTCAGAGCAAGCTGG
CTGAGCGCGTGCGGGACTCCTGGAAGGAAGATGCCTTATTTGGGTACCAGTTTCTTAATGGCGCCAACCCCGTGGTGCTGAGGCGCTCTG
CTCACCTTCCTGCTCGCCTAGTGTTCCCTCCAGGCATGGAGGAACTGCAGGCCCAGCTGGAGAAGGAGCTGGAGGGAGGCACACTGTTCG
AAGCTGACTTCTCCCTGCTGGATGGGATCAAGGCCAACGTCATTCTCTGTAGCCAGCAGCACCTGGCTGCCCCTCTAGTCATGCTGAAAT
TGCAGCCTGATGGGAAACTCTTGCCCATGGTCATCCAGCTCCAGCTGCCCCGCACAGGATCCCCACCACCTCCCCTTTTCTTGCCTACGG
ATCCCCCAATGGCCTGGCTTCTGGCCAAATGCTGGGTGCGCAGCTCTGACTTCCAGCTCCATGAGCTGCAGTCTCATCTTCTGAGGGGAC
ACTTGATGGCTGAGGTCATTGTTGTGGCCACCATGAGGTGCCTGCCGTCGATACATCCTATCTTCAAGTCAGGAGCTCTTCTTGCCTGTG
GCATAGTGAACTCTGGGGTCCGGAATGAGTGTGACCCTGCTCTGGCACTGCTCTCAGACTATGTTCTCCACAACAGCAACACCATGAGAC
TTGGTTCCATCTTTGGGCTAGGCTTGGCTTATGCTGGCTCAAATCGTGAAGATGTCCTAACACTGCTGCTGCCTGTGATGGGAGATTCAA
AGTCCAGCATGGAGGTGGCAGGTGTCACAGCTTTAGCCTGTGGAATGATAGCAGTAGGGTCCTGCAATGGAGATGTAACTTCCACTATCC
TTCAGACCATCATGGAGAAGTCAGAGACTGAGCTCAAGGATACTTATGCTCGTTGGCTTCCTCTTGGACTGGGTCTCAACCACCTGGGGA
AGGGTGAGGCCATCGAGGCAATCCTGGCTGCACTGGAGGTTGTGTCAGAGCCATTCCGCAGTTTTGCCAACACACTGGTGGATGTGTGTG
CATATGCAGGCTCTGGGAATGTGCTGAAGGTGCAGCAGCTGCTCCACATTTGTAGCGAACACTTTGACTCCAAAGAGAAGGAGGAAGACA
AAGACAAGAAGGAAAAGAAAGACAAGGACAAGAAGGAAGCCCCTGCTGACATGGGAGCACATCAGGGAGTGGCTGTTCTGGGGATTGCCC
TTATTGCTATGGGGGAGGAGATTGGTGCAGAGATGGCATTACGAACCTTTGGCCACTTGCTGAGATATGGGGAGCCTACACTCCGGAGGG
CTGTACCTTTAGCACTGGCCCTCATCTCTGTTTCAAATCCACGACTCAACATCCTGGATACCCTAAGCAAATTCTCTCATGATGCTGATC
CAGAAGTTTCCTATAACTCCATTTTTGCCATGGGCATGGTGGGCAGTGGTACCAATAATGCCCGTCTGGCTGCAATGCTGCGCCAGTTAG
CTCAATATCATGCCAAGGACCCAAACAACCTCTTCATGGTGCGCTTGGCACAGGGCCTGACACATTTAGGGAAGGGCACCCTTACCCTCT
GCCCCTACCACAGCGACCGGCAGCTTATGAGCCAGGTGGCCGTGGCTGGACTGCTCACTGTGCTTGTCTCTTTCCTGGATGTTCGAAACA
TTATTCTAGGCAAATCACACTATGTATTGTATGGGCTGGTGGCTGCCATGCAGCCCCGAATGCTGGTTACGTTTGATGAGGAGCTGCGGC
CATTGCCAGTGTCTGTCCGTGTGGGCCAGGCAGTGGATGTGGTGGGCCAGGCTGGCAAGCCGAAGACTATCACAGGGTTCCAGACGCATA
CAACCCCAGTGTTGTTGGCCCACGGGGAACGGGCAGAATTGGCCACTGAGGAGTTTCTTCCTGTTACCCCCATTCTGGAAGGTTTTGTTA
TCCTTCGGAAGAACCCCAATTATGATCTCTAAGTGACCACCAGGGGCTCTGAACTGCAGCTGATGTTATCAGCAGGCCATGCATCCTGCT
GCCAAGGGTGGACACGGCTGCAGACTTCTGGGGGAATTGTCGCCTCCTGCTCTTTTGTTACTGAGTGAGATAAGGTTGTTCAATAAAGAC
TTTTATCCCC

>4095_4095_12_ALOX15-PSMD2_ALOX15_chr17_4539053_ENST00000574640_PSMD2_chr3_184021734_ENST00000439383_length(amino acids)=855AA_BP=388
METCHPHSDPKRPPRGRGLRLGYLARPPFSTRRSETSLSKMGLYRIRVSTGASLYAGSNNQVQLWLVGQHGEAALGKRLWPARGKGPGAG
DEVRFPCYRWVEGNGVLSLPEGTGRTVGEDPQGLFQKHREEELEERRKLYRWGNWKDGLILNMAGAKLYDLPVDERFLEDKRVDFEVSLA
KGLADLAIKDSLNVLTCWKDLDDFNRIFWCGQSKLAERVRDSWKEDALFGYQFLNGANPVVLRRSAHLPARLVFPPGMEELQAQLEKELE
GGTLFEADFSLLDGIKANVILCSQQHLAAPLVMLKLQPDGKLLPMVIQLQLPRTGSPPPPLFLPTDPPMAWLLAKCWVRSSDFQLHELQS
HLLRGHLMAEVIVVATMRCLPSIHPIFKSGALLACGIVNSGVRNECDPALALLSDYVLHNSNTMRLGSIFGLGLAYAGSNREDVLTLLLP
VMGDSKSSMEVAGVTALACGMIAVGSCNGDVTSTILQTIMEKSETELKDTYARWLPLGLGLNHLGKGEAIEAILAALEVVSEPFRSFANT
LVDVCAYAGSGNVLKVQQLLHICSEHFDSKEKEEDKDKKEKKDKDKKEAPADMGAHQGVAVLGIALIAMGEEIGAEMALRTFGHLLRYGE
PTLRRAVPLALALISVSNPRLNILDTLSKFSHDADPEVSYNSIFAMGMVGSGTNNARLAAMLRQLAQYHAKDPNNLFMVRLAQGLTHLGK
GTLTLCPYHSDRQLMSQVAVAGLLTVLVSFLDVRNIILGKSHYVLYGLVAAMQPRMLVTFDEELRPLPVSVRVGQAVDVVGQAGKPKTIT
GFQTHTTPVLLAHGERAELATEEFLPVTPILEGFVILRKNPNYDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ALOX15-PSMD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ALOX15-PSMD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ALOX15-PSMD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneALOX15C0004153Atherosclerosis1CTD_human
HgeneALOX15C0014859Esophageal Neoplasms1CTD_human
HgeneALOX15C0020538Hypertensive disease1CTD_human
HgeneALOX15C0027430Nasal Polyps1CTD_human
HgeneALOX15C0546837Malignant neoplasm of esophagus1CTD_human
HgeneALOX15C1135196Heart Failure, Diastolic1CTD_human
HgeneALOX15C1563937Atherogenesis1CTD_human