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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FTH1-CXXC4 (FusionGDB2 ID:HG2495TG80319)

Fusion Gene Summary for FTH1-CXXC4

check button Fusion gene summary
Fusion gene informationFusion gene name: FTH1-CXXC4
Fusion gene ID: hg2495tg80319
HgeneTgene
Gene symbol

FTH1

CXXC4

Gene ID

2495

80319

Gene nameferritin heavy chain 1CXXC finger protein 4
SynonymsFHC|FTH|FTHL6|HFE5|PIG15|PLIFIDAX
Cytomap('FTH1')('CXXC4')

11q12.3

4q24

Type of geneprotein-codingprotein-coding
Descriptionferritin heavy chainapoferritincell proliferation-inducing gene 15 proteinferritin H subunitferritin, heavy polypeptide 1placenta immunoregulatory factorproliferation-inducing protein 15CXXC-type zinc finger protein 4CXXC finger 4Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex)inhibition of the Dvl and axin complex protein
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000273550, ENST00000526640, 
ENST00000529191, ENST00000529631, 
ENST00000532601, 
Fusion gene scores* DoF score29 X 25 X 6=43502 X 3 X 2=12
# samples 493
** MAII scorelog2(49/4350*10)=-3.15016174662088
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: FTH1 [Title/Abstract] AND CXXC4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFTH1(61734940)-CXXC4(105412493), # samples:76
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFTH1

GO:0006880

intracellular sequestering of iron ion

9924025

HgeneFTH1

GO:0048147

negative regulation of fibroblast proliferation

9924025

TgeneCXXC4

GO:0030178

negative regulation of Wnt signaling pathway

11113207



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-04-1338-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-04-1348-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-04-1362-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-04-1519-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-09-0367-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-10-0934-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-0720-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0765-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0797-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0800-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-0801-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0884-01BFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0893-01BFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0897-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-0906-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-0908-01BFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-0911-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-1404-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-1405-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1408-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1410-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1411-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1483-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1488-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1489-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1489-02AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-1497-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1498-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1501-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-13-1506-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1507-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1509-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-13-1511-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-20-0987-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-20-1682-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-20-1683-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-23-1023-01RFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1026-01BFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-23-1028-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-23-1030-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1109-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1110-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1118-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1120-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1122-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-23-1123-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-0970-01BFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-0975-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1104-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1105-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1416-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1418-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-1423-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1549-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1553-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-1555-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-1557-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-1563-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-1616-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-1850-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-24-2023-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-2024-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-24-2267-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1313-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1315-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-25-1316-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1318-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-25-1319-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1321-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1322-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1328-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1625-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1635-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-1870-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-25-2400-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1688-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-29-1690-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1691-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-29-1695-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1703-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-29-1705-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1710-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1711-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1770-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-1770-02AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-29-2427-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-30-1718-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-30-1860-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-30-1862-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-30-1866-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-30-1891-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-31-1944-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-31-1946-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-31-1951-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-31-1953-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-31-1959-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-36-1568-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-36-1576-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-57-1585-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-1721-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-1736-01BFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-1738-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-61-1919-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-61-2002-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-2009-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-2092-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-61-2097-01AFTH1chr11

61734945

-CXXC4chr4

105412498

-
ChimerDB4OVTCGA-61-2101-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-
ChimerDB4OVTCGA-61-2104-01AFTH1chr11

61734940

-CXXC4chr4

105412493

-


Top

Fusion Gene ORF analysis for FTH1-CXXC4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000273550ENST00000394767FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-3CDSENST00000273550ENST00000394767FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-3CDSENST00000526640ENST00000394767FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-3CDSENST00000526640ENST00000394767FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-3CDSENST00000529191ENST00000394767FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-3CDSENST00000529191ENST00000394767FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-3CDSENST00000529631ENST00000394767FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-3CDSENST00000529631ENST00000394767FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-3CDSENST00000532601ENST00000394767FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-3CDSENST00000532601ENST00000394767FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000273550ENST00000426831FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000273550ENST00000426831FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000273550ENST00000466963FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000273550ENST00000466963FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000526640ENST00000426831FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000526640ENST00000426831FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000526640ENST00000466963FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000526640ENST00000466963FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000529191ENST00000426831FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000529191ENST00000426831FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000529191ENST00000466963FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000529191ENST00000466963FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000529631ENST00000426831FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000529631ENST00000426831FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000529631ENST00000466963FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000529631ENST00000466963FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000532601ENST00000426831FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000532601ENST00000426831FTH1chr11

61734945

-CXXC4chr4

105412498

-
intron-intronENST00000532601ENST00000466963FTH1chr11

61734940

-CXXC4chr4

105412493

-
intron-intronENST00000532601ENST00000466963FTH1chr11

61734945

-CXXC4chr4

105412498

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for FTH1-CXXC4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


Top

Fusion Protein Features for FTH1-CXXC4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:61734940/:105412493)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for FTH1-CXXC4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for FTH1-CXXC4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FTH1-CXXC4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FTH1-CXXC4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFTH1C0011573Endogenous depression1CTD_human
HgeneFTH1C0011581Depressive disorder1CTD_human
HgeneFTH1C0011616Contact Dermatitis1CTD_human
HgeneFTH1C0017638Glioma1CTD_human
HgeneFTH1C0022548Keloid1CTD_human
HgeneFTH1C0025193Melancholia1CTD_human
HgeneFTH1C0027626Neoplasm Invasiveness1CTD_human
HgeneFTH1C0032927Precancerous Conditions1CTD_human
HgeneFTH1C0041696Unipolar Depression1CTD_human
HgeneFTH1C0086133Depressive Syndrome1CTD_human
HgeneFTH1C0162351Contact hypersensitivity1CTD_human
HgeneFTH1C0259783mixed gliomas1CTD_human
HgeneFTH1C0270715Degenerative Diseases, Central Nervous System1CTD_human
HgeneFTH1C0282126Depression, Neurotic1CTD_human
HgeneFTH1C0282193Iron Overload1CTD_human
HgeneFTH1C0282313Condition, Preneoplastic1CTD_human
HgeneFTH1C0345967Malignant mesothelioma1CTD_human
HgeneFTH1C0524851Neurodegenerative Disorders1CTD_human
HgeneFTH1C0555198Malignant Glioma1CTD_human
HgeneFTH1C0751733Degenerative Diseases, Spinal Cord1CTD_human
HgeneFTH1C1851316Iron Overload, Autosomal Dominant1CTD_human;GENOMICS_ENGLAND;ORPHANET