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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CERS6-ZC3H15 (FusionGDB2 ID:HG253782TG55854)

Fusion Gene Summary for CERS6-ZC3H15

check button Fusion gene summary
Fusion gene informationFusion gene name: CERS6-ZC3H15
Fusion gene ID: hg253782tg55854
HgeneTgene
Gene symbol

CERS6

ZC3H15

Gene ID

253782

55854

Gene nameceramide synthase 6zinc finger CCCH-type containing 15
SynonymsCERS5|LASS6HT010|LEREPO4|MSTP012
Cytomap('CERS6')('ZC3H15')

2q24.3

2q32.1

Type of geneprotein-codingprotein-coding
Descriptionceramide synthase 6LAG1 homolog, ceramide synthase 6longevity assurance homolog 6zinc finger CCCH domain-containing protein 15DRG family-regulatory protein 1likely ortholog of mouse immediate early response erythropoietin 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000305747, ENST00000392687, 
Fusion gene scores* DoF score18 X 12 X 8=17285 X 5 X 2=50
# samples 225
** MAII scorelog2(22/1728*10)=-2.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/50*10)=0
Context

PubMed: CERS6 [Title/Abstract] AND ZC3H15 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCERS6(169487552)-ZC3H15(187359960), # samples:1
Anticipated loss of major functional domain due to fusion event.CERS6-ZC3H15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-ZC3H15 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-ZC3H15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CERS6-ZC3H15 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCERS6

GO:0046513

ceramide biosynthetic process

17609214|17977534

TgeneZC3H15

GO:0043547

positive regulation of GTPase activity

23711155


check buttonFusion gene breakpoints across CERS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZC3H15 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GT-01ACERS6chr2

169487552

+ZC3H15chr2

187359960

+


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Fusion Gene ORF analysis for CERS6-ZC3H15

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000305747ENST00000468120CERS6chr2

169487552

+ZC3H15chr2

187359960

+
5CDS-3UTRENST00000392687ENST00000468120CERS6chr2

169487552

+ZC3H15chr2

187359960

+
5CDS-5UTRENST00000305747ENST00000544130CERS6chr2

169487552

+ZC3H15chr2

187359960

+
5CDS-5UTRENST00000392687ENST00000544130CERS6chr2

169487552

+ZC3H15chr2

187359960

+
In-frameENST00000305747ENST00000337859CERS6chr2

169487552

+ZC3H15chr2

187359960

+
In-frameENST00000392687ENST00000337859CERS6chr2

169487552

+ZC3H15chr2

187359960

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000305747CERS6chr2169487552+ENST00000337859ZC3H15chr2187359960+288810522872257656
ENST00000392687CERS6chr2169487552+ENST00000337859ZC3H15chr2187359960+25016651401870576

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000305747ENST00000337859CERS6chr2169487552+ZC3H15chr2187359960+0.0013492130.99865085
ENST00000392687ENST00000337859CERS6chr2169487552+ZC3H15chr2187359960+0.0012488220.99875116

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Fusion Genomic Features for CERS6-ZC3H15


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CERS6chr2169487552+ZC3H15chr2187359959+0.000658510.9993414
CERS6chr2169487552+ZC3H15chr2187359959+0.000658510.9993414

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CERS6-ZC3H15


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:169487552/chr2:187359960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+41066_127155385.0RegionHomeobox-like
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+41166_127155393.0RegionHomeobox-like
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+4101_34155385.0Topological domainLumenal
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+4111_34155393.0Topological domainLumenal
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+41035_55155385.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+41135_55155393.0TransmembraneHelical
TgeneZC3H15chr2:169487552chr2:187359960ENST00000337859010218_28525427.0Coiled coilOntology_term=ECO:0000255
TgeneZC3H15chr2:169487552chr2:187359960ENST0000033785901061_8625427.0Coiled coilOntology_term=ECO:0000255
TgeneZC3H15chr2:169487552chr2:187359960ENST00000337859010174_21225427.0Zinc fingerC3H1-type 2
TgeneZC3H15chr2:169487552chr2:187359960ENST0000033785901099_12625427.0Zinc fingerC3H1-type 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410130_331155385.0DomainTLC
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411130_331155393.0DomainTLC
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410324_384155385.0Topological domainCytoplasmic
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411324_384155393.0Topological domainCytoplasmic
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410178_198155385.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410205_225155385.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410263_283155385.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000305747+410303_323155385.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411178_198155393.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411205_225155393.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411263_283155393.0TransmembraneHelical
HgeneCERS6chr2:169487552chr2:187359960ENST00000392687+411303_323155393.0TransmembraneHelical


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Fusion Gene Sequence for CERS6-ZC3H15


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16011_16011_1_CERS6-ZC3H15_CERS6_chr2_169487552_ENST00000305747_ZC3H15_chr2_187359960_ENST00000337859_length(transcript)=2888nt_BP=1052nt
AGGGCTGGTTCTGAAGCTTGGCGGCAGCCCCTACCTGCTGACCCACCGCCTCCGGGCGCACGGGAAGAGGACTGAGAGCCCTGAAACCCC
AGCGGGGCAGGAGCCAGCATTCTGAGCATGTGCGAGCCAGCCAGGGGGCTAGGGCGGATTTGGGGGGTCGACTTTAGGTCGTCGCCCTAA
GCGCAAAGCGAAAGAGCGGTGAGAGCAGGGGCGGGCGACACTCCCCGGAGCGGTGCCCCTGCGCCCAGGGCGCAGCGACTGCGCCCTGCC
CTGCGGGTGTGGGCGAGTTGGCCGCGTGTGTGCCTCGCTGTTTGACGCGAAGACGAGCCAATCAGGGCGGGCGGCCCGAGCTGCCATGTG
ACGGGCAAGGCGGCCCCTTTCCCCAGCGCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGG
AGGCGGCGGCGGCGGGCGGGAGCAGCGGCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAG
AGCTTGGCGGGCTGCGGGTGCCGCAGGACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGC
TCCCGCACAATGTCACCTGGGCGGACCTGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGG
CCTTCTGTATCTTCATGGTGCGGCTCATCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCAC
AAATTGCTCCGCCCAATGCCATTCTGGAAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGC
AACTGGACTGGGATGTTCGAAGCATTCAGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGA
GCATGTGGAGATTTTCATTTTACCTTTATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGGACAAAACTTTCGGTTTGAAGAATAAGA
AAGGAGCAAAGCAACAGAAGTTTATCAAGGCTGTCACACATCAAGTTAAATTTGGTCAACAAAATCCACGTCAGGTAGCACAGAGTGAAG
CTGAAAAGAAATTGAAGAAGGATGACAAGAAGAAAGAATTGCAGGAGCTAAATGAGCTGTTCAAACCTGTAGTTGCTGCTCAAAAAATAA
GTAAAGGTGCAGATCCCAAGTCTGTAGTATGTGCATTCTTCAAGCAAGGACAGTGTACTAAAGGAGATAAGTGTAAGTTCTCCCATGACT
TGACTCTGGAGAGAAAATGTGAAAAGCGAAGTGTTTACATTGATGCAAGAGATGAAGAACTTGAAAAAGATACTATGGATAATTGGGATG
AGAAAAAGCTGGAAGAAGTAGTGAACAAGAAGCACGGTGAGGCGGAAAAGAAAAAACCAAAAACTCAAATAGTGTGCAAGCATTTCCTGG
AAGCTATTGAAAACAACAAGTATGGCTGGTTTTGGGTATGCCCTGGAGGGGGTGATATTTGCATGTATCGTCATGCACTTCCTCCTGGAT
TTGTGTTGAAAAAAGATAAAAAGAAAGAAGAGAAAGAAGATGAAATTTCATTAGAAGATCTAATTGAGAGAGAGCGTTCTGCCCTAGGTC
CAAATGTTACCAAAATCACTCTAGAATCTTTTCTTGCCTGGAAGAAAAGGAAAAGACAAGAAAAGATTGATAAACTTGAACAAGATATGG
AAAGAAGGAAAGCTGACTTCAAAGCAGGGAAAGCACTAGTGATCAGTGGTCGTGAAGTGTTTGAATTTCGTCCTGAACTGGTCAATGATG
ATGATGAGGAAGCAGATGATACCCGCTACACCCAGGGAACAGGTGGTGATGAGGTTGATGATTCAGTGAGTGTAAATGACATAGATTTAA
GCCTGTACATCCCAAGAGATGTAGATGAAACAGGTATTACTGTAGCCAGTCTTGAAAGATTCAGCACATATACTTCAGATAAAGATGAAA
ACAAATTAAGTGAAGCTTCTGGAGGTAGGGCTGAAAATGGTGAAAGAAGTGACTTGGAAGAGGACAACGAGAGGGAGGGAACGGAAAATG
GAGCCATTGATGCTGTTCCTGTTGATGAAAATCTTTTCACTGGAGAGGATTTGGATGAACTAGAAGAAGAATTAAATACACTTGATTTAG
AAGAATGACACCAAACACATCGCTGAAAAAATTAAGTCAGCTCAGCACGAGTTGAAATTGACTACATTAATTTCTTTCCACCTAGAATCA
ACAGGATGTTTATTTCCTATGCTGATTCTGGAGGAGTTAACCTCCTGCAAAAAAGGCATCTTGTCCCTACATCTTCTCTTCTGACTTTGG
CTACATCTCATAGTAAGTTCAGAGTAGTTCATGATAAATTGAAAATATAATGGTCATTGCAGAAAATGATTGATGTTGTAACTGTCCACC
CAAGTAAGAAGTGTATCTGCCTTTCCATCTTTTGGTTTTCATTTGGGCATGTGCTATTACCAGAAACAACAAACTTATATTTAAAATACC
CTTCATTTGACACAGTTTTTAATGAGTGATTTAATTTCCTCTGTATTTGTATGTTTAGAAGACTGCCTAAAACATGAGCACTGTACTTCA
TAAAGGAAACTGCGTATGCAGATTCAGTATTGTGTATCTTTGGACAATTAGATGGACATTTAAAATGGAACTTCTTTTATCTGACAGGAT
CAGCTACAATGCCCTGTGTTAAATTGTTTAAAAGTTTCCCTTTTCTTTTTTGCCAATAAAGTTGTAAATAAAGACCATCATACATTAAAA
TCCAAATA

>16011_16011_1_CERS6-ZC3H15_CERS6_chr2_169487552_ENST00000305747_ZC3H15_chr2_187359960_ENST00000337859_length(amino acids)=656AA_BP=249
MAACVPRCLTRRRANQGGRPELPCDGQGGPFPQRGQREERTGARREPSRAAAAEEAAAAGGSSGGGGTGSGPAGRASPGALRGGELGGLR
VPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQANGPQIAPPN
AILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKDKTFGLKNKKGAKQQ
KFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCKFSHDLTLERK
CEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHALPPGFVLKKD
KKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPELVNDDDEEAD
DTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNEREGTENGAIDAV
PVDENLFTGEDLDELEEELNTLDLEE

--------------------------------------------------------------
>16011_16011_2_CERS6-ZC3H15_CERS6_chr2_169487552_ENST00000392687_ZC3H15_chr2_187359960_ENST00000337859_length(transcript)=2501nt_BP=665nt
GCGGCCAGAGGGAGGAGAGAACCGGGGCTCGCCGCGAGCCTTCGAGAGCAGCGGCCGCGGAGGAGGCGGCGGCGGCGGGCGGGAGCAGCG
GCGGCGGCGGCACAGGCTCGGGGCCAGCCGGGCGCGCATCCCCGGGCGCCCTGCGCGGTGGAGAGCTTGGCGGGCTGCGGGTGCCGCAGG
ACAGGAGTGGACAAAGCAAGATGGCAGGGATCTTAGCCTGGTTCTGGAACGAGAGGTTTTGGCTCCCGCACAATGTCACCTGGGCGGACC
TGAAGAACACGGAGGAGGCCACCTTCCCGCAGGCTGAGGACCTCTATCTCGCTTTTCCCCTGGCCTTCTGTATCTTCATGGTGCGGCTCA
TCTTCGAGAGATTTGTAGCCAAACCGTGCGCCATAGCCCTCAACATTCAGGCCAATGGACCACAAATTGCTCCGCCCAATGCCATTCTGG
AAAAGGTCTTCACTGCAATTACAAAGCATCCTGATGAAAAGAGATTGGAAGGCCTCTCCAAGCAACTGGACTGGGATGTTCGAAGCATTC
AGCGCTGGTTTCGACAAAGACGCAATCAGGAGAAGCCAAGCACGCTGACGAGGTTCTGTGAGAGCATGTGGAGATTTTCATTTTACCTTT
ATGTATTTACCTACGGAGTCAGATTCCTGAAAAAGGACAAAACTTTCGGTTTGAAGAATAAGAAAGGAGCAAAGCAACAGAAGTTTATCA
AGGCTGTCACACATCAAGTTAAATTTGGTCAACAAAATCCACGTCAGGTAGCACAGAGTGAAGCTGAAAAGAAATTGAAGAAGGATGACA
AGAAGAAAGAATTGCAGGAGCTAAATGAGCTGTTCAAACCTGTAGTTGCTGCTCAAAAAATAAGTAAAGGTGCAGATCCCAAGTCTGTAG
TATGTGCATTCTTCAAGCAAGGACAGTGTACTAAAGGAGATAAGTGTAAGTTCTCCCATGACTTGACTCTGGAGAGAAAATGTGAAAAGC
GAAGTGTTTACATTGATGCAAGAGATGAAGAACTTGAAAAAGATACTATGGATAATTGGGATGAGAAAAAGCTGGAAGAAGTAGTGAACA
AGAAGCACGGTGAGGCGGAAAAGAAAAAACCAAAAACTCAAATAGTGTGCAAGCATTTCCTGGAAGCTATTGAAAACAACAAGTATGGCT
GGTTTTGGGTATGCCCTGGAGGGGGTGATATTTGCATGTATCGTCATGCACTTCCTCCTGGATTTGTGTTGAAAAAAGATAAAAAGAAAG
AAGAGAAAGAAGATGAAATTTCATTAGAAGATCTAATTGAGAGAGAGCGTTCTGCCCTAGGTCCAAATGTTACCAAAATCACTCTAGAAT
CTTTTCTTGCCTGGAAGAAAAGGAAAAGACAAGAAAAGATTGATAAACTTGAACAAGATATGGAAAGAAGGAAAGCTGACTTCAAAGCAG
GGAAAGCACTAGTGATCAGTGGTCGTGAAGTGTTTGAATTTCGTCCTGAACTGGTCAATGATGATGATGAGGAAGCAGATGATACCCGCT
ACACCCAGGGAACAGGTGGTGATGAGGTTGATGATTCAGTGAGTGTAAATGACATAGATTTAAGCCTGTACATCCCAAGAGATGTAGATG
AAACAGGTATTACTGTAGCCAGTCTTGAAAGATTCAGCACATATACTTCAGATAAAGATGAAAACAAATTAAGTGAAGCTTCTGGAGGTA
GGGCTGAAAATGGTGAAAGAAGTGACTTGGAAGAGGACAACGAGAGGGAGGGAACGGAAAATGGAGCCATTGATGCTGTTCCTGTTGATG
AAAATCTTTTCACTGGAGAGGATTTGGATGAACTAGAAGAAGAATTAAATACACTTGATTTAGAAGAATGACACCAAACACATCGCTGAA
AAAATTAAGTCAGCTCAGCACGAGTTGAAATTGACTACATTAATTTCTTTCCACCTAGAATCAACAGGATGTTTATTTCCTATGCTGATT
CTGGAGGAGTTAACCTCCTGCAAAAAAGGCATCTTGTCCCTACATCTTCTCTTCTGACTTTGGCTACATCTCATAGTAAGTTCAGAGTAG
TTCATGATAAATTGAAAATATAATGGTCATTGCAGAAAATGATTGATGTTGTAACTGTCCACCCAAGTAAGAAGTGTATCTGCCTTTCCA
TCTTTTGGTTTTCATTTGGGCATGTGCTATTACCAGAAACAACAAACTTATATTTAAAATACCCTTCATTTGACACAGTTTTTAATGAGT
GATTTAATTTCCTCTGTATTTGTATGTTTAGAAGACTGCCTAAAACATGAGCACTGTACTTCATAAAGGAAACTGCGTATGCAGATTCAG
TATTGTGTATCTTTGGACAATTAGATGGACATTTAAAATGGAACTTCTTTTATCTGACAGGATCAGCTACAATGCCCTGTGTTAAATTGT
TTAAAAGTTTCCCTTTTCTTTTTTGCCAATAAAGTTGTAAATAAAGACCATCATACATTAAAATCCAAATA

>16011_16011_2_CERS6-ZC3H15_CERS6_chr2_169487552_ENST00000392687_ZC3H15_chr2_187359960_ENST00000337859_length(amino acids)=576AA_BP=169
MRGGELGGLRVPQDRSGQSKMAGILAWFWNERFWLPHNVTWADLKNTEEATFPQAEDLYLAFPLAFCIFMVRLIFERFVAKPCAIALNIQ
ANGPQIAPPNAILEKVFTAITKHPDEKRLEGLSKQLDWDVRSIQRWFRQRRNQEKPSTLTRFCESMWRFSFYLYVFTYGVRFLKKDKTFG
LKNKKGAKQQKFIKAVTHQVKFGQQNPRQVAQSEAEKKLKKDDKKKELQELNELFKPVVAAQKISKGADPKSVVCAFFKQGQCTKGDKCK
FSHDLTLERKCEKRSVYIDARDEELEKDTMDNWDEKKLEEVVNKKHGEAEKKKPKTQIVCKHFLEAIENNKYGWFWVCPGGGDICMYRHA
LPPGFVLKKDKKKEEKEDEISLEDLIERERSALGPNVTKITLESFLAWKKRKRQEKIDKLEQDMERRKADFKAGKALVISGREVFEFRPE
LVNDDDEEADDTRYTQGTGGDEVDDSVSVNDIDLSLYIPRDVDETGITVASLERFSTYTSDKDENKLSEASGGRAENGERSDLEEDNERE
GTENGAIDAVPVDENLFTGEDLDELEEELNTLDLEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CERS6-ZC3H15


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CERS6-ZC3H15


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CERS6-ZC3H15


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCERS6C0013146Drug abuse1CTD_human
HgeneCERS6C0013170Drug habituation1CTD_human
HgeneCERS6C0013222Drug Use Disorders1CTD_human
HgeneCERS6C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCERS6C0038580Substance Dependence1CTD_human
HgeneCERS6C0038586Substance Use Disorders1CTD_human
HgeneCERS6C0236969Substance-Related Disorders1CTD_human
HgeneCERS6C0740858Substance abuse problem1CTD_human
HgeneCERS6C1510472Drug Dependence1CTD_human
HgeneCERS6C4316881Prescription Drug Abuse1CTD_human