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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BRWD3-FAM155A (FusionGDB2 ID:HG254065TG728215)

Fusion Gene Summary for BRWD3-FAM155A

check button Fusion gene summary
Fusion gene informationFusion gene name: BRWD3-FAM155A
Fusion gene ID: hg254065tg728215
HgeneTgene
Gene symbol

BRWD3

FAM155A

Gene ID

254065

728215

Gene namebromodomain and WD repeat domain containing 3family with sequence similarity 155 member A
SynonymsBRODL|MRX93-
Cytomap('BRWD3')('FAM155A')

Xq21.1

13q33.3

Type of geneprotein-codingprotein-coding
Descriptionbromodomain and WD repeat-containing protein 3bromo domain-containing protein disrupted in leukemianovel WD repeat domain proteintransmembrane protein FAM155A
Modification date2020031320200313
UniProtAcc

Q6RI45

B1AL88

Ensembl transtripts involved in fusion geneENST00000373275, ENST00000473691, 
Fusion gene scores* DoF score3 X 3 X 3=2715 X 11 X 4=660
# samples 416
** MAII scorelog2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(16/660*10)=-2.04439411935845
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BRWD3 [Title/Abstract] AND FAM155A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBRWD3(80047353)-FAM155A(107823134), # samples:3
Anticipated loss of major functional domain due to fusion event.BRWD3-FAM155A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BRWD3-FAM155A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across BRWD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM155A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-QK-A8ZB-01ABRWD3chrX

80047353

-FAM155Achr13

107823134

-
ChimerDB4HNSCTCGA-QK-A8ZBBRWD3chrX

80047352

-FAM155Achr13

107823134

-
ChimerDB4HNSCTCGA-QK-A8ZBBRWD3chrX

80047353

-FAM155Achr13

107823134

-


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Fusion Gene ORF analysis for BRWD3-FAM155A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000373275ENST00000375915BRWD3chrX

80047353

-FAM155Achr13

107823134

-
In-frameENST00000373275ENST00000375915BRWD3chrX

80047352

-FAM155Achr13

107823134

-
intron-3CDSENST00000473691ENST00000375915BRWD3chrX

80047353

-FAM155Achr13

107823134

-
intron-3CDSENST00000473691ENST00000375915BRWD3chrX

80047352

-FAM155Achr13

107823134

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000373275BRWD3chrX80047353-ENST00000375915FAM155Achr13107823134-2899647217936239
ENST00000373275BRWD3chrX80047352-ENST00000375915FAM155Achr13107823134-2899647217936239

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373275ENST00000375915BRWD3chrX80047353-FAM155Achr13107823134-0.0007636660.99923635
ENST00000373275ENST00000375915BRWD3chrX80047352-FAM155Achr13107823134-0.0007636660.99923635

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Fusion Genomic Features for BRWD3-FAM155A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for BRWD3-FAM155A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:80047353/chr13:107823134)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
BRWD3

Q6RI45

FAM155A

B1AL88

FUNCTION: Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM155AchrX:80047352chr13:107823134ENST0000037591513417_437362459.0TransmembraneHelical
TgeneFAM155AchrX:80047353chr13:107823134ENST0000037591513417_437362459.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-6411659_17191431803.0Compositional biasNote=Gly-rich
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-6411659_17191431803.0Compositional biasNote=Gly-rich
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-6411158_12281431803.0DomainBromo 1
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-6411317_14121431803.0DomainBromo 2
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-6411158_12281431803.0DomainBromo 1
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-6411317_14121431803.0DomainBromo 2
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641170_2091431803.0RepeatNote=WD 1
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641213_2511431803.0RepeatNote=WD 2
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641255_2971431803.0RepeatNote=WD 3
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641307_3471431803.0RepeatNote=WD 4
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641353_3931431803.0RepeatNote=WD 5
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641400_4521431803.0RepeatNote=WD 6
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641456_4951431803.0RepeatNote=WD 7
HgeneBRWD3chrX:80047352chr13:107823134ENST00000373275-641502_5421431803.0RepeatNote=WD 8
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641170_2091431803.0RepeatNote=WD 1
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641213_2511431803.0RepeatNote=WD 2
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641255_2971431803.0RepeatNote=WD 3
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641307_3471431803.0RepeatNote=WD 4
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641353_3931431803.0RepeatNote=WD 5
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641400_4521431803.0RepeatNote=WD 6
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641456_4951431803.0RepeatNote=WD 7
HgeneBRWD3chrX:80047353chr13:107823134ENST00000373275-641502_5421431803.0RepeatNote=WD 8
TgeneFAM155AchrX:80047352chr13:107823134ENST0000037591513136_145362459.0Compositional biasNote=Poly-Gly
TgeneFAM155AchrX:80047352chr13:107823134ENST000003759151373_95362459.0Compositional biasNote=Poly-Gln
TgeneFAM155AchrX:80047353chr13:107823134ENST0000037591513136_145362459.0Compositional biasNote=Poly-Gly
TgeneFAM155AchrX:80047353chr13:107823134ENST000003759151373_95362459.0Compositional biasNote=Poly-Gln
TgeneFAM155AchrX:80047352chr13:107823134ENST000003759151340_60362459.0TransmembraneHelical
TgeneFAM155AchrX:80047353chr13:107823134ENST000003759151340_60362459.0TransmembraneHelical


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Fusion Gene Sequence for BRWD3-FAM155A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>10366_10366_1_BRWD3-FAM155A_BRWD3_chrX_80047352_ENST00000373275_FAM155A_chr13_107823134_ENST00000375915_length(transcript)=2899nt_BP=647nt
CTCTCCTTCCTCCTCCGCCTCCTCAGCTCTTGGGCTAGAATATCTATGGGTCGAAACGTGATGCGATGAATTCGAGAGAGAGCGAAACTA
GGACGAGGAGTGCGGCGGAAGCGGCGGGACTCCCGGGCATGGGGGCTTCACCACAATAGAGGCAGCGCCCCCACCCGCCCCCGCCAGCCC
CTCCGGAGCGAAGCCCCCAAACCCCCTCGGGAAAAGGATGGCGGCAGCACCTACCCAGATCGAAGCCGAGCTGTATTACCTGATCGCTAG
GTTCTTGCAGTCTGGACCCTGCAACAAATCCGCTCAGGTGCTAGTGCAGGAGCTCGAGGAGCATCAGCTGATTCCGCGCCGCTTAGATTG
GGAGGGGAAAGAGCACCGAAGAAGCTTCGAGGATCTGGTGGCAGCAAATGCACACATTCCTCCAGACTACCTCCTTAAAATTTGTGAGAG
AATTGGTCCTTTACTAGATAAAGAGATCCCTCAGAGTGTTCCTGGGGTACAGACATTATTAGGTGTTGGTCGGCAGTCTCTGCTACGGGA
TGCCAAAGACTGTAAGAGTACACTATGGAATGGGTCTGCTTTTGCGGCTCTGCATAGAGGCAGACCTCCAGAACTACCTGTAAATTATGT
GAAACCTCCAAATGTGGGGCTTTATGAAACCTTTCTAACCAATGATGAACCAGAATGCTGTGACGTCAGGAGAGAAGAAAAATCAAATAA
CCCATCCAAAGGGACCGTAGAGAAAAGTGGCTCCTGTCACAGGACATCGCTCACAGTGTCATCAGCAACAAGACTGTGCAACAGCAGACT
CAAGCTGTGTGTTCTTGTACTGATTCTCTTACACACAGTGCTCACAGCCTCGGCAGCACAGAACACAGCCGGACTGAGCTTTGGAGGCAT
CAACACGCTGGAAGAAAACTCAACCAATGAGGAGTAACGGAAGGACGAGTGTCACCACAGCAGCAGCTGGCCCGCCGTGAAAAATGGCAA
CTGCTGTCTCATGTAACAGAAACTGGGTGCTTTTACCCTCGAATTACTTATTGCAAGGCCTTTAGGGTAAAATTTAAACAGATGGGCCTG
AATCCAAACAAGGACACAACCACAGCTTTTTATTGACTAAAAGGCTGGAAAGTGACTTTAAATTTCTCACACCATTTTATACACTGTGTT
TTAATGTTTGGAGGTTTTATTTGCTTTCGTTTTGGTTTGGGTTTATTTGTTTGTTTATTTTTTGCACTTGTTAATACAGGATTTATTTTG
GGGGATGGTTTCTCAGAGGTAAACTAAGTCTTTTCACTGTCTCTATCTCTCTATATATTTCTAGTCATTGTGTGTGTTCATCAGATAGTT
CTGTCTTTATGTCCTGTCAGCTTCTATTAGAGGAATGATTGCTATGACCTCATGGTATAGCAAAAAACAACAACAAAAAAAGAATAAAAA
ATAAAAAAGACAAAAAAAAGAAAACAACAAAAAAATAAAAATAAAAAAAATCCCTAAGTCTCCCTTCTACCCACAGAACCAACAACACCC
TTCCCGGCCTTTCCTTTCCCTCGCCCTCTTCTCGTCCCCTAAGCAAACAACATCCGCTTGCTTCTGTCTGTGTAACCACAGTGAATGGGT
GTGCACGCTTGGTGGGCCTCTGAGCCCCTGTTGCACAAACCAGAAACAGAGCGGAGCCAAGGGGGCCTGACAAGAGTTCCTTTTTAGCTG
AACAAACAAGTGCTCTCCATAATAGGTGGAATCAGACAGTTAACACATTTTTATGTTGAAAACAAAATAAAAGGAAAAAATTAAAAAAAA
CTATCATGAACTGTATTGCTCCAGTTCCCATCCCCAAGTGGCCCAGCCCTTTCTTGCTGGTCCAGTTGGACAGGAGCAGCTATCTAGAAT
CAGGATGCGGGGAGTGAGGAAGTTTTTCTTTTGACAATGAAGGTGGGCTTTCATTGTGATTTTTGTTCTGTTGCAGTAATATAGGAGCAC
ATTTTGGCCATTGTAATTACAGGGAACAAACAAAGGGATTGCGGACACATATCTGGACTTCTTTTCCTCCCTTATTGTTGTGGAAGAGAC
ACTAGAAATGCTCAAACACCTGCAATATACAGAATATACACAATTTTATTCCAGTATTTCCCTAACATATGGTTTAAAATTATTCCAGGT
ATACAGTGTATGCAATTCTGCATTATCACAGAGGAACAACTTCTTTTTTAAAAAATAAATAGGTCAGCCATTTTTATTAACGTGCAAAAA
CTTTATCACTCTAACATGCTCTAGGTAGTTGAGGAAAAGAGGTCTGATCACTGTTTGTATTTTATTTTCTTTGTGGGAACATTTCACCTG
CTGAGTGTACATGAATTTGCTTTCTATAAAAGGCTTTTATGAGTTTACAGTAGAATCAGTGGAAGGAAGAGTTAATAAGGGCTGTTTTTA
AAAAAACAAACAAACAAACAAAACAAATAATTAAAAAAAAAATTTTACATTCCTTCCTATTCTCTAACTACACTTGGGAAGTGCACTTCA
GATAAGTTTGCAGTGTGACTGAGAGATGAAGGAAATCCATAGAAAAGGTCCTCTTAGTGAACAAAATTTAGTTATTAACTTTATAGCTAT
GAAATTTCCCCGGGCATTTGTTTTTGTTCAAACAGACTTTAACCTCTGCATCATACTTAACCCTGCGACATGCGTACAGTATGCATATTT
TGTTTTGAAAAAAAATGTTTCGTTCCAGTCTGTTAAGAATATTCAAAAATAATAAAGGTATTGCTTAATAAAATTGCTAGAATTGTTTAG
CAGTACATGCACAATATTTTACTAGATTCTTTGTTTTAATAGTGTTTTGTTGAGACTGAAAATCTTAAAATGGTCTGCGCAAATACAAAA

>10366_10366_1_BRWD3-FAM155A_BRWD3_chrX_80047352_ENST00000373275_FAM155A_chr13_107823134_ENST00000375915_length(amino acids)=239AA_BP=143
MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQS
VPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVGLYETFLTNDEPECCDVRREEKSNNPSKGTVEKSGSC

--------------------------------------------------------------
>10366_10366_2_BRWD3-FAM155A_BRWD3_chrX_80047353_ENST00000373275_FAM155A_chr13_107823134_ENST00000375915_length(transcript)=2899nt_BP=647nt
CTCTCCTTCCTCCTCCGCCTCCTCAGCTCTTGGGCTAGAATATCTATGGGTCGAAACGTGATGCGATGAATTCGAGAGAGAGCGAAACTA
GGACGAGGAGTGCGGCGGAAGCGGCGGGACTCCCGGGCATGGGGGCTTCACCACAATAGAGGCAGCGCCCCCACCCGCCCCCGCCAGCCC
CTCCGGAGCGAAGCCCCCAAACCCCCTCGGGAAAAGGATGGCGGCAGCACCTACCCAGATCGAAGCCGAGCTGTATTACCTGATCGCTAG
GTTCTTGCAGTCTGGACCCTGCAACAAATCCGCTCAGGTGCTAGTGCAGGAGCTCGAGGAGCATCAGCTGATTCCGCGCCGCTTAGATTG
GGAGGGGAAAGAGCACCGAAGAAGCTTCGAGGATCTGGTGGCAGCAAATGCACACATTCCTCCAGACTACCTCCTTAAAATTTGTGAGAG
AATTGGTCCTTTACTAGATAAAGAGATCCCTCAGAGTGTTCCTGGGGTACAGACATTATTAGGTGTTGGTCGGCAGTCTCTGCTACGGGA
TGCCAAAGACTGTAAGAGTACACTATGGAATGGGTCTGCTTTTGCGGCTCTGCATAGAGGCAGACCTCCAGAACTACCTGTAAATTATGT
GAAACCTCCAAATGTGGGGCTTTATGAAACCTTTCTAACCAATGATGAACCAGAATGCTGTGACGTCAGGAGAGAAGAAAAATCAAATAA
CCCATCCAAAGGGACCGTAGAGAAAAGTGGCTCCTGTCACAGGACATCGCTCACAGTGTCATCAGCAACAAGACTGTGCAACAGCAGACT
CAAGCTGTGTGTTCTTGTACTGATTCTCTTACACACAGTGCTCACAGCCTCGGCAGCACAGAACACAGCCGGACTGAGCTTTGGAGGCAT
CAACACGCTGGAAGAAAACTCAACCAATGAGGAGTAACGGAAGGACGAGTGTCACCACAGCAGCAGCTGGCCCGCCGTGAAAAATGGCAA
CTGCTGTCTCATGTAACAGAAACTGGGTGCTTTTACCCTCGAATTACTTATTGCAAGGCCTTTAGGGTAAAATTTAAACAGATGGGCCTG
AATCCAAACAAGGACACAACCACAGCTTTTTATTGACTAAAAGGCTGGAAAGTGACTTTAAATTTCTCACACCATTTTATACACTGTGTT
TTAATGTTTGGAGGTTTTATTTGCTTTCGTTTTGGTTTGGGTTTATTTGTTTGTTTATTTTTTGCACTTGTTAATACAGGATTTATTTTG
GGGGATGGTTTCTCAGAGGTAAACTAAGTCTTTTCACTGTCTCTATCTCTCTATATATTTCTAGTCATTGTGTGTGTTCATCAGATAGTT
CTGTCTTTATGTCCTGTCAGCTTCTATTAGAGGAATGATTGCTATGACCTCATGGTATAGCAAAAAACAACAACAAAAAAAGAATAAAAA
ATAAAAAAGACAAAAAAAAGAAAACAACAAAAAAATAAAAATAAAAAAAATCCCTAAGTCTCCCTTCTACCCACAGAACCAACAACACCC
TTCCCGGCCTTTCCTTTCCCTCGCCCTCTTCTCGTCCCCTAAGCAAACAACATCCGCTTGCTTCTGTCTGTGTAACCACAGTGAATGGGT
GTGCACGCTTGGTGGGCCTCTGAGCCCCTGTTGCACAAACCAGAAACAGAGCGGAGCCAAGGGGGCCTGACAAGAGTTCCTTTTTAGCTG
AACAAACAAGTGCTCTCCATAATAGGTGGAATCAGACAGTTAACACATTTTTATGTTGAAAACAAAATAAAAGGAAAAAATTAAAAAAAA
CTATCATGAACTGTATTGCTCCAGTTCCCATCCCCAAGTGGCCCAGCCCTTTCTTGCTGGTCCAGTTGGACAGGAGCAGCTATCTAGAAT
CAGGATGCGGGGAGTGAGGAAGTTTTTCTTTTGACAATGAAGGTGGGCTTTCATTGTGATTTTTGTTCTGTTGCAGTAATATAGGAGCAC
ATTTTGGCCATTGTAATTACAGGGAACAAACAAAGGGATTGCGGACACATATCTGGACTTCTTTTCCTCCCTTATTGTTGTGGAAGAGAC
ACTAGAAATGCTCAAACACCTGCAATATACAGAATATACACAATTTTATTCCAGTATTTCCCTAACATATGGTTTAAAATTATTCCAGGT
ATACAGTGTATGCAATTCTGCATTATCACAGAGGAACAACTTCTTTTTTAAAAAATAAATAGGTCAGCCATTTTTATTAACGTGCAAAAA
CTTTATCACTCTAACATGCTCTAGGTAGTTGAGGAAAAGAGGTCTGATCACTGTTTGTATTTTATTTTCTTTGTGGGAACATTTCACCTG
CTGAGTGTACATGAATTTGCTTTCTATAAAAGGCTTTTATGAGTTTACAGTAGAATCAGTGGAAGGAAGAGTTAATAAGGGCTGTTTTTA
AAAAAACAAACAAACAAACAAAACAAATAATTAAAAAAAAAATTTTACATTCCTTCCTATTCTCTAACTACACTTGGGAAGTGCACTTCA
GATAAGTTTGCAGTGTGACTGAGAGATGAAGGAAATCCATAGAAAAGGTCCTCTTAGTGAACAAAATTTAGTTATTAACTTTATAGCTAT
GAAATTTCCCCGGGCATTTGTTTTTGTTCAAACAGACTTTAACCTCTGCATCATACTTAACCCTGCGACATGCGTACAGTATGCATATTT
TGTTTTGAAAAAAAATGTTTCGTTCCAGTCTGTTAAGAATATTCAAAAATAATAAAGGTATTGCTTAATAAAATTGCTAGAATTGTTTAG
CAGTACATGCACAATATTTTACTAGATTCTTTGTTTTAATAGTGTTTTGTTGAGACTGAAAATCTTAAAATGGTCTGCGCAAATACAAAA

>10366_10366_2_BRWD3-FAM155A_BRWD3_chrX_80047353_ENST00000373275_FAM155A_chr13_107823134_ENST00000375915_length(amino acids)=239AA_BP=143
MAAAPTQIEAELYYLIARFLQSGPCNKSAQVLVQELEEHQLIPRRLDWEGKEHRRSFEDLVAANAHIPPDYLLKICERIGPLLDKEIPQS
VPGVQTLLGVGRQSLLRDAKDCKSTLWNGSAFAALHRGRPPELPVNYVKPPNVGLYETFLTNDEPECCDVRREEKSNNPSKGTVEKSGSC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BRWD3-FAM155A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BRWD3-FAM155A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BRWD3-FAM155A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneBRWD3C0796250PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME4CLINGEN
HgeneBRWD3C1970841MENTAL RETARDATION, X-LINKED 93 (disorder)2CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneBRWD3C0221355Macrocephaly1GENOMICS_ENGLAND
HgeneBRWD3C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneC0012813Diverticulitis1CTD_human
TgeneC4317009Diverticular Diseases1CTD_human
TgeneC4505353Diverticular Bleeding1CTD_human