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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAK-MAGI1 (FusionGDB2 ID:HG2580TG9223)

Fusion Gene Summary for GAK-MAGI1

check button Fusion gene summary
Fusion gene informationFusion gene name: GAK-MAGI1
Fusion gene ID: hg2580tg9223
HgeneTgene
Gene symbol

GAK

MAGI1

Gene ID

2580

9223

Gene namecyclin G associated kinasemembrane associated guanylate kinase, WW and PDZ domain containing 1
SynonymsDNAJ26|DNAJC26AIP-3|AIP3|BAIAP1|BAP-1|BAP1|MAGI-1|MAGI-1b|Magi1d|TNRC19|WWP3
Cytomap('GAK')('MAGI1')

4p16.3

3p14.1

Type of geneprotein-codingprotein-coding
Descriptioncyclin-G-associated kinaseauxilin-2membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1BAI1-associated protein 1WW domain-containing protein 3atrophin-1-interacting protein 3membrane-associated guanylate kinase inverted 1trinucleotide repeat-containing gene 19
Modification date2020031320200313
UniProtAcc

O14976

.
Ensembl transtripts involved in fusion geneENST00000314167, ENST00000509566, 
ENST00000511163, 
Fusion gene scores* DoF score16 X 17 X 8=217617 X 15 X 5=1275
# samples 1817
** MAII scorelog2(18/2176*10)=-3.59560974492067
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1275*10)=-2.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAK [Title/Abstract] AND MAGI1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAK(905461)-MAGI1(65607763), # samples:3
Anticipated loss of major functional domain due to fusion event.GAK-MAGI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAK-MAGI1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAK-MAGI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAK-MAGI1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAK

GO:0010977

negative regulation of neuron projection development

24510904

TgeneMAGI1

GO:0022409

positive regulation of cell-cell adhesion

20298433


check buttonFusion gene breakpoints across GAK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MAGI1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07R-01AGAKchr4

905461

-MAGI1chr3

65607763

-


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Fusion Gene ORF analysis for GAK-MAGI1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000314167ENST00000470990GAKchr4

905461

-MAGI1chr3

65607763

-
In-frameENST00000314167ENST00000330909GAKchr4

905461

-MAGI1chr3

65607763

-
In-frameENST00000314167ENST00000402939GAKchr4

905461

-MAGI1chr3

65607763

-
In-frameENST00000314167ENST00000483466GAKchr4

905461

-MAGI1chr3

65607763

-
In-frameENST00000314167ENST00000497477GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000509566ENST00000330909GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000509566ENST00000402939GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000509566ENST00000483466GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000509566ENST00000497477GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000511163ENST00000330909GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000511163ENST00000402939GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000511163ENST00000483466GAKchr4

905461

-MAGI1chr3

65607763

-
intron-3CDSENST00000511163ENST00000497477GAKchr4

905461

-MAGI1chr3

65607763

-
intron-5UTRENST00000509566ENST00000470990GAKchr4

905461

-MAGI1chr3

65607763

-
intron-5UTRENST00000511163ENST00000470990GAKchr4

905461

-MAGI1chr3

65607763

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000314167GAKchr4905461-ENST00000330909MAGI1chr365607763-759549311140431310
ENST00000314167GAKchr4905461-ENST00000402939MAGI1chr365607763-456949311145681485
ENST00000314167GAKchr4905461-ENST00000483466MAGI1chr365607763-472949311139501279
ENST00000314167GAKchr4905461-ENST00000497477MAGI1chr365607763-373549311136621183

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314167ENST00000330909GAKchr4905461-MAGI1chr365607763-0.0003247840.9996753
ENST00000314167ENST00000402939GAKchr4905461-MAGI1chr365607763-0.0033996660.99660033
ENST00000314167ENST00000483466GAKchr4905461-MAGI1chr365607763-0.0016073580.99839264
ENST00000314167ENST00000497477GAKchr4905461-MAGI1chr365607763-0.0045801870.99541986

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Fusion Genomic Features for GAK-MAGI1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GAK-MAGI1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:905461/chr3:65607763)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAK

O14976

.
FUNCTION: Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1. {ECO:0000269|PubMed:10625686}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMAGI1chr4:905461chr3:65607763ENST000003309090251341_13441041288.0Compositional biasNote=Poly-Ala
TgeneMAGI1chr4:905461chr3:65607763ENST000003309090251398_14011041288.0Compositional biasNote=Poly-Arg
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025402_4211041288.0Compositional biasNote=Poly-Gln
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025662_6651041288.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025978_9881041288.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST000004029390231341_13441041463.0Compositional biasNote=Poly-Ala
TgeneMAGI1chr4:905461chr3:65607763ENST000004029390231398_14011041463.0Compositional biasNote=Poly-Arg
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023402_4211041463.0Compositional biasNote=Poly-Gln
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023662_6651041463.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023978_9881041463.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST000004834660231341_13441041257.0Compositional biasNote=Poly-Ala
TgeneMAGI1chr4:905461chr3:65607763ENST000004834660231398_14011041257.0Compositional biasNote=Poly-Arg
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023402_4211041257.0Compositional biasNote=Poly-Gln
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023662_6651041257.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023978_9881041257.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST000004974770211341_13441041161.0Compositional biasNote=Poly-Ala
TgeneMAGI1chr4:905461chr3:65607763ENST000004974770211398_14011041161.0Compositional biasNote=Poly-Arg
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021402_4211041161.0Compositional biasNote=Poly-Gln
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021662_6651041161.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021978_9881041161.0Compositional biasNote=Poly-Gly
TgeneMAGI1chr4:905461chr3:65607763ENST000003309090251124_12061041288.0DomainPDZ 6
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025300_3331041288.0DomainWW 1
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025359_3921041288.0DomainWW 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025472_5541041288.0DomainPDZ 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025643_7211041288.0DomainPDZ 3
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025813_8951041288.0DomainPDZ 4
TgeneMAGI1chr4:905461chr3:65607763ENST000004029390231124_12061041463.0DomainPDZ 6
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023300_3331041463.0DomainWW 1
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023359_3921041463.0DomainWW 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023472_5541041463.0DomainPDZ 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023643_7211041463.0DomainPDZ 3
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023813_8951041463.0DomainPDZ 4
TgeneMAGI1chr4:905461chr3:65607763ENST000004834660231124_12061041257.0DomainPDZ 6
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023300_3331041257.0DomainWW 1
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023359_3921041257.0DomainWW 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023472_5541041257.0DomainPDZ 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023643_7211041257.0DomainPDZ 3
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023813_8951041257.0DomainPDZ 4
TgeneMAGI1chr4:905461chr3:65607763ENST000004974770211124_12061041161.0DomainPDZ 6
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021300_3331041161.0DomainWW 1
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021359_3921041161.0DomainWW 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021472_5541041161.0DomainPDZ 2
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021643_7211041161.0DomainPDZ 3
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021813_8951041161.0DomainPDZ 4
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025103_1101041288.0Nucleotide bindingATP
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023103_1101041463.0Nucleotide bindingATP
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023103_1101041257.0Nucleotide bindingATP
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021103_1101041161.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAKchr4:905461chr3:65607763ENST00000314167-428347_3501271312.0Compositional biasNote=Poly-Pro
HgeneGAKchr4:905461chr3:65607763ENST00000314167-4281247_13111271312.0DomainJ
HgeneGAKchr4:905461chr3:65607763ENST00000314167-428399_5661271312.0DomainPhosphatase tensin-type
HgeneGAKchr4:905461chr3:65607763ENST00000314167-42840_3141271312.0DomainProtein kinase
HgeneGAKchr4:905461chr3:65607763ENST00000314167-428572_7101271312.0DomainC2 tensin-type
TgeneMAGI1chr4:905461chr3:65607763ENST0000033090902517_1051041288.0DomainPDZ 1
TgeneMAGI1chr4:905461chr3:65607763ENST0000033090902596_2871041288.0DomainGuanylate kinase-like
TgeneMAGI1chr4:905461chr3:65607763ENST0000040293902317_1051041463.0DomainPDZ 1
TgeneMAGI1chr4:905461chr3:65607763ENST0000040293902396_2871041463.0DomainGuanylate kinase-like
TgeneMAGI1chr4:905461chr3:65607763ENST0000048346602317_1051041257.0DomainPDZ 1
TgeneMAGI1chr4:905461chr3:65607763ENST0000048346602396_2871041257.0DomainGuanylate kinase-like
TgeneMAGI1chr4:905461chr3:65607763ENST0000049747702117_1051041161.0DomainPDZ 1
TgeneMAGI1chr4:905461chr3:65607763ENST0000049747702196_2871041161.0DomainGuanylate kinase-like


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Fusion Gene Sequence for GAK-MAGI1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32174_32174_1_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000330909_length(transcript)=7595nt_BP=493nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTC
CAGAAGGGGTCTCCTGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGA
GAAGGAGAAGTGCCTGGCGTGGACTATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGC
ACCTATGAAGGAAACTATTATGGGACACCCAAGCCTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTT
CAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTACAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAG
GAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAAGAGGAGCACACTCTCCAAGAAACAGCATTACCACCT
GTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTACCTCTTTCTGCAGAGGATAATTTAGGT
CCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAACAACATCTTGGTTAGAC
CCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAACTAGAA
CTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCG
GTTCTAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGACAGAAGAATGGACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAA
GTTCCACTTCAGGGCAAACCCTTTTTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGT
GGCTTTGGCTTCACGGTGGTTGGAGGGGATGAACCTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGAT
GGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACACCTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAG
TCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTGCCTTTTGATCCAGATGACCCCAATACAAGTTTAGTG
ACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCACCAGCTAGCCACAGTAGTAAAACAGGC
AAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCCTAATGACACTGTTTCT
TTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCAGACAGT
CCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAAT
AAGAAGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAA
CGAGGAGGGCTGCCAGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCC
AGCCACCGAAGCCTGCACACAGCATCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAA
ACTGACAGCTCTGGCCAGAAAAAACCAGATCCTTTTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACCTATGTCACCTTCA
CCTGCGTCGGGATTGAGCAAGGGTGAGAGAGAGAGAGAAATCAATTCCACGAATTTTGGAGAATGTCCGATTCCAGATTACCAGGAACAG
GACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGTCACATC
GTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGGATGGGACGCCAGTAATTGGAAAATCA
CACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGTGGTTTTTGCGGTGCCC
AAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACTCCGCAG
GGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGCGTGGTC
AGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGCCC
GAAGCAGGCACGACCTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGTGGC
AAGCTGAAAGTAGGAGACCGGATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAGGAA
GCGGGAAACACAGTTACCCTCCGCATCATTCCTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATC
ACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCA
CCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAG
TATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATTTTAGAG
ATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGTTCGTCTGTTTCTGAAG
CGGGGAGACGGCTCAGTACCAGAATATGCGATGATACCTCCTAATATCGCTGCATGTATGAGAAATGAAAAGCTCGGGGAGGCTTGCTTC
TACCTTATGGGCCATAATCAAACTACGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACAAGGTGTTCCGGAAGTGAGGGCCG
GGCCCGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAAAAGCGGGCACACG
CAAGGGATCCGAAAGGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGACAGCGGGG
CATGCCGACCCAAGGACCGGGCGCCGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGGCGGTCCC
CAGAGAAGCGGAGGGAGGGCACCCGCAGCGCCGACAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCTCCGGAGC
GGAGGCGAGAGCGGTCACCCACCCGCAGGAGAGACGGCTCCCCCAGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAGAGGAGGT
CCCCCGAGCGCAGGAGAGGGGGCTCGCCCGAGCGCAGGGCCAAGTCCACCGACCGGAGGCGCGCACGCTCCCCCGAGCGCAGGAGAGAGC
GGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAGCCACCGAGAAAGGGAAGAGGCGAATCTGAAACAGGATGCCGGCAGAAGTTCCA
GACATCCCCCGGAGCAGAGAAGGCGACCTTACAAAGAATGTAGCACCGACCTCAGTATCTGAGACGCTGAGTCACATTCCAACCTTTACC
GTGTCAAAGGTTCTAAGAGGAAAGTCACAAACCTGAAATTATTTAGTTTCTTACCTAATGAAGCATCTGACACCTGATGATCCTATGAAT
AACAACAAACATTTTATGCATTTGAAATCTTATAAGAAAAAATATATATGAAAAGTATTGTGCCTGATGTATCATATTAAAGAAAGTATT
TTTAAATGCATACTTTTTTGGAAATTATTTGCCAAATGCTGGCCCAAAGGGATATAAATTTTGTTTCTACGTAACCTGTAGAATCGTCAA
GAATTGTTCCCGTTTTGGGGCAATCTTTTTCTCTCCTGGTTAAATGGGGCTGTTGATCATTTTCTCTACGTAAGGGAATTTATTGATTAA
GTTTAATTAATTTGATATAGACTGTCATGTAGTGATGTAGTGCTATACTGTAGTCGGAAGTTTTTCTTAAAAGCAAAGAGCAAAAATGCA
AAGTTTTATTTGTAAAAGCTGAGGACCCTTGGGGATGGATTAGGTTTGCCGATGATCCTAAAAGTAAGCAAACTGTATGACAAGACTACT
ATTGCAAATGAAGGATATTTATAGCTAAACTGCGCAGCACAAAGAAGTTTTATATTGTGAGTTATAGTTGGTTCAGAAAACAGTTTGTAC
TCTCCCTGGCCCAGGAAGGCACACAGACAAAAATGTCGGCCACTTTTACTCAAATACAGCCCAAGCACAGACAGTCAGGTTCGTGATCAT
CACCAACATCTGATAAAATCTCATTGAAGGCAATGCCATCACAGCTTTGCTCAATTACTACGAGGAAGAGACAACAAGCATCTTTCGTGT
TGTCTCGTCTGATTGGAGGCTGAATAGTAGATGGAATGGGGGGACAGTGTGCCTGGTGTGAGGAAGACGTAAGATCCCCAATTTGGAAAG
CATGCCCCCCTCCCTTTTAGTAGAAGCCCATGGTTGCCCTTTGCCAAACTGGGGAGGAGGCAATGAGCCTTGGTGGAAGGAACCTCTCTG
TTGATATTTAAAGAAGTGAGGGCTGTGGGTATTCATTGTTAGAAATGCCAATTTCACTTTGAAACCATAGTCCAAGTCTCTAGGTTGGTA
GAAGGGAAAGGAAGGAAGTGGTCCCAGTGATTCTAGGTCTGGTTGGGAAACTTCTGCCTCATGACTCTGTCCTTTGAGTCCTTTGGACAG
CAGCACAAAACATAACAATTTTTATTTTTAAACAGACCCATTCTTTTTGATCCCACAGGAGCTGTGGTTGGGTCGGCCGTAGCCCCGGGA
TGTGGTTTAAGTGGATTACTGCCTAGCTGAGCCAAAATGTTTGCTTGTACCTGTTGGACCACTACAGCAAACCGCTGCTTACAGTGCATT
GTGTATTTCTGTAGTACTGTTTTGCATTTTCCATAGAGACAGAAAACTTTGCAAGTCAATCACTGTTGTTCCCATGGTACTGTAAGAAAA
AAAAAAAGGAAAAAGAAAAAAAAAAAGAAAACCAGCCAATCATTGCGTGTACAGAGCTAAAAATTGTAATTAATAGAGCCTGTTGGGAAA
AAAAAGAAAACAACTGTTGCCTTTTTTTCTTGTATAAAAGAGAATTTATGACAAAATTTAGCTGTGAGGAATGTGATACGTGTTTATATT
TCTGAATATGGAACAAATTGATTCATGGGGATATATTTTAATGTAAACTAAATCAGGTATGTAAAGTTGTTTTAAAATGGGAGACTATAT
AAGTAATTCTCTAAAGCTTTAGTTGGTTTGAATATCATCATTTCCTCCATGGTGAGCCTGCTTGTGAATTATTAAGCACTTGTTTGCATT
CTCTGTTCTTCACTCATTTATTTCTTGCAGTGTGCTATGGACTTAATGCTCTTTCTGTATTGATGAAAAGCAGTATGTGGGCCAATCTTT
TTATAAAACACTATGCATATATAAATATTACATTGTTCATAGCTTTATTTGACTTATGGGTTTATACATAACATTAGAATGAGTAGCTGT
AGTTGTGTGGACATTTATAAAACAAGTTCCTTTCCTGGAACAGACACAATATACATTCTGTAGCTAAAAAGGAGGGAAAAGTCTGTGAAT
GCTATTTTTATTATTAAAGTTTTCCATACAAAGCATACATTGAGCTGTAGTAAGGCTGAGGAAGAGTACAACTGAATAATGATGTTCTTT
TTCATCAAGTTCCTAAGAGCTGACTTGGAGATTTTATTCCCAGGGCTCCACTGCTAGGATTCTTCTCACTAGTTCTAACAAAATCTGTGA
TGTTAAATGACTGATGCTCTCAATTGTGATCCAGAGTTTTAAATAAATGAAATCAAGGTGGATTTTGGGAATATATCCTGAAGTTAACAT
CTTGATGTCCTTCTTGTTGTAAGATGATATTTGGCAATTTAAAATCTATGTGCTACCCACCTGGGCTTGTCTCAATCCGTGGACTTTTTG
GTGTGGCAGTTTCACCTGAATTCCACACATCAGATTTGTTTGGAAATATTGTACTGTACAGGGACTATGCATTATGCAGAAAGATATAGT
TTTCTTTGAACTGCTGTAACCTTAAATTGGAAACTGATTCTTGTGAGCCTACTTTCCTTAATCCCGCCGCCCCCCTCCCCCACTTAATGT
AAATGTCTTGATGAGAGATAATGGATGAGTATTTTGTATGATGAAATCAAACGATTTAGGAATTTGTCTCCCTCCGTTACACAGTTGATG
CCTGAAAGAATGTTGGGGGGGAGGACTCAACACCCTAATTGTATTTTTTAAGTTTCTTTTGTGAAAGATTTTTTAATGCATTTTTACTGT

>32174_32174_1_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000330909_length(amino acids)=1310AA_BP=127
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGV
DYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEM
NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQ
QKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTE
DHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGD
VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKD
ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQAL
THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK
KPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAAD
TDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN
TVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDR
ILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQ
DFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVP

--------------------------------------------------------------
>32174_32174_2_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000402939_length(transcript)=4569nt_BP=493nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTC
CAGAAGGGGTCTCCTGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGA
GAAGGAGAAGTGCCTGGCGTGGACTATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGC
ACCTATGAAGGAAACTATTATGGGACACCCAAGCCTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTT
CAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTACAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAG
GAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAAGAGGAGCACACTCTCCAAGAAACAGCATTACCACCT
GTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTACCTCTTTCTGCAGAGGATAATTTAGGT
CCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAACAACATCTTGGTTAGAC
CCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAACTAGAA
CTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCG
GTTCTAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGACAGAAGAATGGACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAA
GTTCCACTTCAGGGCAAACCCTTTTTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGT
GGCTTTGGCTTCACGGTGGTTGGAGGGGATGAACCTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGAT
GGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACACCTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAG
TCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTGCCTTTTGATCCAGATGACCCCAATACAAGTTTAGTG
ACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCACCAGCTAGCCACAGTAGTAAAACAGGC
AAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCCTAATGACACTGTTTCT
TTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCAGACAGT
CCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAAT
AAGAAGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAA
CGAGGAGGGCTGCCAGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCC
AGCCACCGAAGCCTGCACACAGCATCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAA
ACTGACAGCTCTGGCCAGAAAAAACCAGATCCTTTTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACTTCCAGATTACCAG
GAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGT
CACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGGATGGGACGCCAGTAATTGGA
AAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGTGGTTTTTGCG
GTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACT
CCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGC
GTGGTCAGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGC
AGGCCCGAAGCAGGCACGACCTTTGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGC
TGTGGCAAGCTGAAAGTAGGAGACCGGATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATC
AAGGAAGCGGGAAACACAGTTACCCTCCGCATCATTCCTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCC
ACCATCACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTC
AAAGCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGC
CGAGAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATT
TTAGAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGTTCGTCTGTTT
CTGAAGCGGGGAGACGGCTCAGTACCAGAATATGACCCCAGCAGCGACCGCCACGGCCCCGCCACCGGTCCACAAGGTGTTCCGGAAGTG
AGGGCCGGGCCCGACCGCCGGCAGCATCCGTCATTGGAGTCCAGTTACCCACCCGATCTTCACAAATCATCACCACATGGGGAAAAGCGG
GCACACGCAAGGGATCCGAAAGGCAGCAGAGAGTATAGCAGACAACCCAATGAACACCACACCTGGAATGGGACTTCGAGGAAACCCGAC
AGCGGGGCATGCCGACCCAAGGACCGGGCGCCGGAGGGACGGAGGGACGCGCAGGCCGAGCGCGCGGCAGCCGCCAACGGCCCCAAGAGG
CGGTCCCCAGAGAAGCGGAGGGAGGGCACCCGCAGCGCCGACAACACTTTGGAGAGGAGGGAGAAGCACGAGAAGAGACGAGACGTCTCT
CCGGAGCGGAGGCGAGAGCGGTCACCCACCCGCAGGAGAGACGGCTCCCCCAGCCGGCGGAGACGGTCTCTGGAGAGACTCCTGGAGCAG
AGGAGGTCCCCCGAGCGCAGGAGAGGGGGCTCGCCCGAGCGCAGGGCCAAGTCCACCGACCGGAGGCGCGCACGCTCCCCCGAGCGCAGG
AGAGAGCGGTCCCTGGACAAAAGGAACAGAGAGGACAGAGCCAGCCACCGAGAAAGGGAAGAGGCGAATCTGAAACAGGATGCCGGCAGA

>32174_32174_2_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000402939_length(amino acids)=1485AA_BP=127
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGV
DYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEM
NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQ
QKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTE
DHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGD
VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKD
ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQAL
THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK
KPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV
QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ
PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTV
TLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTVELERGAKGFGFSLRGGREYNMDL
YVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRR
QHPSLESSYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRAPEGRRDAQAERAAAANGPKRRSPEKRR
EGTRSADNTLERREKHEKRRDVSPERRRERSPTRRRDGSPSRRRRSLERLLEQRRSPERRRGGSPERRAKSTDRRRARSPERRRERSLDK

--------------------------------------------------------------
>32174_32174_3_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000483466_length(transcript)=4729nt_BP=493nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTC
CAGAAGGGGTCTCCTGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGA
GAAGGAGAAGTGCCTGGCGTGGACTATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGC
ACCTATGAAGGAAACTATTATGGGACACCCAAGCCTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTT
CAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTACAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAG
GAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAAGAGGAGCACACTCTCCAAGAAACAGCATTACCACCT
GTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTACCTCTTTCTGCAGAGGATAATTTAGGT
CCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAACAACATCTTGGTTAGAC
CCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAACTAGAA
CTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCG
GTTCTAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGACAGAAGAATGGACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAA
GTTCCACTTCAGGGCAAACCCTTTTTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGT
GGCTTTGGCTTCACGGTGGTTGGAGGGGATGAACCTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGAT
GGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACACCTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAG
TCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTGCCTTTTGATCCAGATGACCCCAATACAAGTTTAGTG
ACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCACCAGCTAGCCACAGTAGTAAAACAGGC
AAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCCTAATGACACTGTTTCT
TTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCAGACAGT
CCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAAT
AAGAAGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAA
CGAGGAGGGCTGCCAGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCC
AGCCACCGAAGCCTGCACACAGCATCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAA
ACTGACAGCTCTGGCCAGAAAAAACCAGATCCTTTTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACCTATGTCACCTTCA
CCTGCGTCGGGATTGAGCAAGGGTGAGAGAGAGAGAGAAATCAATTCCACGAATTTTGGAGAATGTCCGATTCCAGATTACCAGGAACAG
GACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGTCACATC
GTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGGATGGGACGCCAGTAATTGGAAAATCA
CACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGTGGTTTTTGCGGTGCCC
AAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACTCCGCAG
GGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGCGTGGTC
AGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGCAGGCCC
GAAGCAGGCACGACCTTTGCAGGCAATGCATGTGTGGCTATGCCTCACAAAATAGGTCGGATTATTGAGGGGAGCCCTGCTGACCGCTGT
GGCAAGCTGAAAGTAGGAGACCGGATCTTGGCAGTAAATGGATGTTCCATCACCAACAAATCCCATTCAGACATTGTGAACCTAATCAAG
GAAGCGGGAAACACAGTTACCCTCCGCATCATTCCTGGGGATGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACC
ATCACCACCACACACACCCCTTCTCAGCAAGGGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAA
GCACCCCAAGCAACACAGGAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGA
GAGTATAACATGGACCTCTATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATTTTA
GAGATCAATGGTGAGACCACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGTTCGTCTGTTTCTG
AAGCGGGGAGACGGCTCAGTACCAGAATATGGTGGGTCAAACTATGAAAACATTCCTTCCTTCCCTGGCATGACTCCATGAATTTGTCTC
CAGAACGGCAGCAGGAAAGTCTTTTTTGTTTCCCCTATTCACCAGTGTCTTACCAGCCTCTCGCACCATGTGATTATTTGCCTCGCTTGT
TCTGAAATCTCTACACATTTCATCCTTTTGCTTGCTTACGTGGACTGGGGCATGGCCTAAGACAAGATCTTTATAGCCCCCTTTCTGATA
ATCAGAGAGAACGTTTTGTCTAGTCCGACCAAGAGCGAAGGAATGTTTGTTTGTACTGTGCCAAACTGTTCCTCAGATCCAATTGTTAGC
ACAAAATGACTATATACTCCTTTTAAGAAGCAGGAAAGCAGGTTTCCTGAGTGATATGTTGAGGCACAATTATTTTTTCCTTTTTGGTTA
CTTGGTGTCTTTATTTAAGAGGCATGAAATTTTGAGAGATTTGGGGGCTTTGCTAACCTCCCTTATGCTCTGTATACAACACTTCTCCAT
CCCCCAACTGGTGTCTTACCCCAAATCAGACCATCTGAGCCCACTACTATCAAACAAACAAACAAAAACTGTTAATATATTAGCCATAAT
GTTTTTAAATGATAAAGGATGAAATAAATTCCCAGTGCTCATCATGAGGGAAACATGTGACTATACCTTTCCTATGAGGAAAGCCAGGTT
ATACATAGAGTTCCTTTGTCATATCTTTAGACTTGATTTGAGTAGACAGCAATGATCTTTACATAGCTTAGTGTTCTGATGGCAAAATAT

>32174_32174_3_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000483466_length(amino acids)=1279AA_BP=127
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGV
DYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEM
NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQ
QKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTE
DHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGD
VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKD
ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQAL
THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK
KPDPFKIWAQSRSMYENRPMSPSPASGLSKGEREREINSTNFGECPIPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAAD
TDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLN
TVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVIVSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGD
RILAVNGCSITNKSHSDIVNLIKEAGNTVTLRIIPGDESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQE
QDFYTVELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSV

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>32174_32174_4_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000497477_length(transcript)=3735nt_BP=493nt
GAAGATGGTGCACCTCCGGGCCGGCGGTTGCTGAGCTGACCCGGACGGCGAGGGAGCGGGAGCCCGAGCCCGACCACTCCGGCTGCCGCG
GGGTGCGGCGCAGCCACCGCCATGTCGCTGCTGCAGTCGGCGCTCGACTTCTTGGCGGGTCCAGGCTCCCTGGGCGGTGCTTCCGGCCGC
GACCAGAGTGACTTCGTGGGGCAGACGGTGGAACTGGGCGAGCTGCGGCTGCGGGTGCGGCGGGTCCTGGCCGAAGGAGGGTTTGCATTT
GTGTATGAAGCTCAAGATGTGGGGAGTGGCAGAGAGTATGCATTAAAGAGGCTATTATCCAATGAAGAGGAAAAGAACAGAGCCATCATT
CAAGAAGTTTGCTTCATGAAAAAGCTTTCCGGCCACCCGAACATTGTCCAGTTTTGTTCTGCAGCGTCTATAGGAAAAGAGGAGTCAGAC
ACGGGGCAGGCTGAGTTCCTCTTGCTCACAGAGCTCTGTAAAGGAGGAAGGCTGAACAAGGACCTGCGACATTTTCTCAATCAGCGATTC
CAGAAGGGGTCTCCTGATCATGAGCTCCAGCAGACCATAAGGGATAACCTTTACCGCCATGCTGTGCCTTGCACAACCCGATCTCCCAGA
GAAGGAGAAGTGCCTGGCGTGGACTATAACTTTCTGACTGTGAAGGAGTTCTTGGACCTCGAGCAGAGTGGGACTCTTCTGGAAGTCGGC
ACCTATGAAGGAAACTATTATGGGACACCCAAGCCTCCTAGCCAGCCAGTCAGTGGGAAAGTGATCACGACGGATGCCTTGCACAGCCTT
CAGTCTGGCTCTAAGCAGTCGACCCCGAAGCGAACCAAGTCCTACAATGATATGCAAAATGCTGGCATAGTCCACGCGGAGAATGAGGAG
GAGGATGACGTTCCTGAAATGAACAGCAGCTTTACAGCCGATTCTGGTGAACAAGAGGAGCACACTCTCCAAGAAACAGCATTACCACCT
GTGAATAGTAGCATCATCGCTGCTCCCATCACGGACCCTTCTCAGAAGTTCCCTCAATACCTACCTCTTTCTGCAGAGGATAATTTAGGT
CCTCTACCTGAAAACTGGGAGATGGCCTATACTGAAAATGGAGAAGTCTATTTTATAGACCATAACACGAAAACAACATCTTGGTTAGAC
CCTCGGTGCCTAAACAAGCAGCAGAAGCCACTGGAAGAGTGTGAAGATGATGAAGGGGTACACACCGAGGAGCTGGACAGTGAACTAGAA
CTGCCTGCTGGTTGGGAAAAGATTGAAGACCCTGTCTATGGTATCTACTATGTAGACCACATCAACAGGAAGACACAATATGAGAACCCG
GTTCTAGAAGCCAAACGGAAGAAGCAGCTTGAGCAGCAGCAGCAGCAGCAACAGCAGCAGCAACAGCAGCAGCAGCAGCAGCAGCAGCAG
CAGACAGAAGAATGGACAGAAGATCACTCAGCCCTTGTGCCTCCTGTTATTCCAAACCACCCTCCAAGCAATCCAGAGCCAGCCAGAGAA
GTTCCACTTCAGGGCAAACCCTTTTTTACACGAAACCCTTCTGAGTTGAAAGGCAAGTTCATTCACACAAAGCTGCGGAAAAGCAGTCGT
GGCTTTGGCTTCACGGTGGTTGGAGGGGATGAACCTGATGAGTTTCTCCAGATCAAGAGCTTGGTCCTAGATGGTCCTGCTGCATTGGAT
GGCAAGATGGAAACAGGGGATGTGATTGTAAGTGTGAATGACACCTGTGTTTTGGGACACACACATGCTCAAGTTGTGAAGATCTTCCAG
TCCATCCCCATTGGTGCCAGCGTGGACCTTGAACTCTGCCGAGGTTATCCATTGCCTTTTGATCCAGATGACCCCAATACAAGTTTAGTG
ACCTCGGTAGCCATTTTGGATAAAGAACCAATTATTGTGAATGGGCAAGAGACCTATGATTCACCAGCTAGCCACAGTAGTAAAACAGGC
AAAGTCAATGGCATGAAGGATGCCAGGCCAAGCAGCCCAGCGGACGTGGCTTCAAATAGTTCTCATGGTTATCCTAATGACACTGTTTCT
TTGGCTTCCTCCATAGCCACTCAGCCAGAACTCATAACTGTTCATATTGTCAAAGGGCCAATGGGCTTTGGTTTTACTATCGCAGACAGT
CCTGGTGGGGGTGGCCAAAGAGTGAAACAGATTGTTGACAGCCCAAGGTGCCGAGGCCTGAAAGAAGGGGATCTCATAGTGGAAGTTAAT
AAGAAGAACGTGCAGGCCCTAACTCACAACCAAGTGGTGGATATGCTGGTTGAGTGTCCTAAGGGAAGTGAGGTCACATTGTTGGTGCAA
CGAGGAGGGCTGCCAGTTCCCAAGAAGAGCCCAAAGTCGCAACCACTGGAAAGGAAAGACAGCCAGAATAGTTCTCAGCACAGTGTTTCC
AGCCACCGAAGCCTGCACACAGCATCCCCAAGCCACAGCACACAGGTGCTCCCCGAGTTCCCACCTGCAGAGGCCCAAGCTCCAGATCAA
ACTGACAGCTCTGGCCAGAAAAAACCAGATCCTTTTAAAATCTGGGCCCAGTCCAGGAGCATGTATGAAAACCGACTTCCAGATTACCAG
GAACAGGACATCTTCCTCTGGAGAAAAGAGACTGGATTTGGATTTAGGATTCTGGGTGGAAATGAACCAGGGGAACCTATTTATATTGGT
CACATCGTACCACTGGGTGCTGCTGATACTGACGGCCGCCTGAGGTCTGGAGATGAATTAATCTGTGTGGATGGGACGCCAGTAATTGGA
AAATCACACCAGCTTGTGGTCCAGCTTATGCAACAAGCTGCCAAGCAAGGCCACGTCAATCTCACGGTGCGGCGTAAAGTGGTTTTTGCG
GTGCCCAAAACCGAGAACGAGGTGCCCTCGCCAGCCTCCTCTCATCACAGTAGCAACCAGCCGGCCTCGCTGACAGAAGAGAAGCGCACT
CCGCAGGGCAGCCAGAACTCGCTGAACACGGTGAGCTCGGGCAGCGGCAGCACCAGCGGCATCGGCAGTGGCGGCGGCGGGGGCAGCGGC
GTGGTCAGCACCGTGGTGCAGCCCTACGACGTGGAGATCCGGCGCGGGGAGAACGAGGGCTTCGGCTTCGTCATCGTGTCCTCGGTGAGC
AGGCCCGAAGCAGGCACGACCTTTGAGTCCTCGAATGCCACCTTGCTGACCAATGCAGAGAAGATTGCCACCATCACCACCACACACACC
CCTTCTCAGCAAGGGACCCAGGAGACAAGGAATACCACCAAACCAAAGCAGGAATCTCAATTTGAGTTCAAAGCACCCCAAGCAACACAG
GAGCAAGATTTTTACACTGTGGAACTGGAAAGAGGAGCCAAGGGATTTGGCTTTAGCCTTCGAGGAGGCCGAGAGTATAACATGGACCTC
TATGTTCTGCGCTTAGCAGAGGACGGTCCTGCGGAGAGGTGTGGAAAGATGAGGATTGGTGATGAAATTTTAGAGATCAATGGTGAGACC
ACCAAAAACATGAAGCATTCTCGAGCTATAGAACTGATTAAGAATGGTGGCCGCAGAGTTCGTCTGTTTCTGAAGCGGGGAGACGGCTCA
GTACCAGAATATGGTGGGTCAAACTATGAAAACATTCCTTCCTTCCCTGGCATGACTCCATGAATTTGTCTCCAGAACGGCAGCAGGAAA

>32174_32174_4_GAK-MAGI1_GAK_chr4_905461_ENST00000314167_MAGI1_chr3_65607763_ENST00000497477_length(amino acids)=1183AA_BP=127
MSLLQSALDFLAGPGSLGGASGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAIIQEVCFMK
KLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPCTTRSPREGEVPGV
DYNFLTVKEFLDLEQSGTLLEVGTYEGNYYGTPKPPSQPVSGKVITTDALHSLQSGSKQSTPKRTKSYNDMQNAGIVHAENEEEDDVPEM
NSSFTADSGEQEEHTLQETALPPVNSSIIAAPITDPSQKFPQYLPLSAEDNLGPLPENWEMAYTENGEVYFIDHNTKTTSWLDPRCLNKQ
QKPLEECEDDEGVHTEELDSELELPAGWEKIEDPVYGIYYVDHINRKTQYENPVLEAKRKKQLEQQQQQQQQQQQQQQQQQQQQTEEWTE
DHSALVPPVIPNHPPSNPEPAREVPLQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGD
VIVSVNDTCVLGHTHAQVVKIFQSIPIGASVDLELCRGYPLPFDPDDPNTSLVTSVAILDKEPIIVNGQETYDSPASHSSKTGKVNGMKD
ARPSSPADVASNSSHGYPNDTVSLASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQIVDSPRCRGLKEGDLIVEVNKKNVQAL
THNQVVDMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHSTQVLPEFPPAEAQAPDQTDSSGQK
KPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV
QLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASLTEEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQ
PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFESSNATLLTNAEKIATITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV
ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIKNGGRRVRLFLKRGDGSVPEYGGS

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Fusion Gene PPI Analysis for GAK-MAGI1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneMAGI1chr4:905461chr3:65607763ENST00000330909025970_1066104.333333333333331288.0FCHSD2
TgeneMAGI1chr4:905461chr3:65607763ENST00000402939023970_1066104.333333333333331463.0FCHSD2
TgeneMAGI1chr4:905461chr3:65607763ENST00000483466023970_1066104.333333333333331257.0FCHSD2
TgeneMAGI1chr4:905461chr3:65607763ENST00000497477021970_1066104.333333333333331161.0FCHSD2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAK-MAGI1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGAKO14976DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational

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Related Diseases for GAK-MAGI1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAKC0030567Parkinson Disease1CTD_human
TgeneC0005586Bipolar Disorder2PSYGENET
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC1839839MAJOR AFFECTIVE DISORDER 21PSYGENET