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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C3orf17-RPN2 (FusionGDB2 ID:HG25871TG6185)

Fusion Gene Summary for C3orf17-RPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: C3orf17-RPN2
Fusion gene ID: hg25871tg6185
HgeneTgene
Gene symbol

C3orf17

RPN2

Gene ID

25871

6185

Gene namenucleolus and neural progenitor proteinribophorin II
SynonymsC3orf17|NET17RIBIIR|RPN-II|RPNII|SWP1
Cytomap('C3orf17')('RPN2')

3q13.2

20q11.23

Type of geneprotein-codingprotein-coding
Descriptionnucleolus and neural progenitor proteinprotein nepro homologdolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunitoligosaccharyltransferase complex subunit (non-catalytic)ribophorin-2
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000314400, ENST00000383675, 
ENST00000393857, ENST00000472762, 
Fusion gene scores* DoF score2 X 2 X 2=812 X 13 X 9=1404
# samples 217
** MAII scorelog2(2/8*10)=1.32192809488736log2(17/1404*10)=-3.04593628416686
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: C3orf17 [Title/Abstract] AND RPN2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC3orf17(112738389)-RPN2(35852281), # samples:1
Anticipated loss of major functional domain due to fusion event.C3orf17-RPN2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C3orf17-RPN2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C3orf17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPN2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-KR-A7K0-01AC3orf17chr3

112738389

-RPN2chr20

35852281

+


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Fusion Gene ORF analysis for C3orf17-RPN2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000314400ENST00000470352C3orf17chr3

112738389

-RPN2chr20

35852281

+
5CDS-intronENST00000383675ENST00000470352C3orf17chr3

112738389

-RPN2chr20

35852281

+
5UTR-3CDSENST00000393857ENST00000237530C3orf17chr3

112738389

-RPN2chr20

35852281

+
5UTR-3CDSENST00000393857ENST00000373622C3orf17chr3

112738389

-RPN2chr20

35852281

+
5UTR-intronENST00000393857ENST00000470352C3orf17chr3

112738389

-RPN2chr20

35852281

+
In-frameENST00000314400ENST00000237530C3orf17chr3

112738389

-RPN2chr20

35852281

+
In-frameENST00000314400ENST00000373622C3orf17chr3

112738389

-RPN2chr20

35852281

+
In-frameENST00000383675ENST00000237530C3orf17chr3

112738389

-RPN2chr20

35852281

+
In-frameENST00000383675ENST00000373622C3orf17chr3

112738389

-RPN2chr20

35852281

+
intron-3CDSENST00000472762ENST00000237530C3orf17chr3

112738389

-RPN2chr20

35852281

+
intron-3CDSENST00000472762ENST00000373622C3orf17chr3

112738389

-RPN2chr20

35852281

+
intron-intronENST00000472762ENST00000470352C3orf17chr3

112738389

-RPN2chr20

35852281

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000314400C3orf17chr3112738389-ENST00000237530RPN2chr2035852281+14062982951101268
ENST00000314400C3orf17chr3112738389-ENST00000373622RPN2chr2035852281+14542982951149284
ENST00000383675C3orf17chr3112738389-ENST00000237530RPN2chr2035852281+1300192189995268
ENST00000383675C3orf17chr3112738389-ENST00000373622RPN2chr2035852281+13481921891043284

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000314400ENST00000237530C3orf17chr3112738389-RPN2chr2035852281+0.73542730.2645727
ENST00000314400ENST00000373622C3orf17chr3112738389-RPN2chr2035852281+0.180025430.8199746
ENST00000383675ENST00000237530C3orf17chr3112738389-RPN2chr2035852281+0.57325170.42674825
ENST00000383675ENST00000373622C3orf17chr3112738389-RPN2chr2035852281+0.167215680.8327843

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Fusion Genomic Features for C3orf17-RPN2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C3orf17chr3112738388-RPN2chr2035852280+0.0001597550.99984026
C3orf17chr3112738388-RPN2chr2035852280+0.0001597550.99984026

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C3orf17-RPN2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:112738389/chr20:35852281)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817562_571364632.0Topological domainCytoplasmic
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817593_596364632.0Topological domainLumenal
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817618_631364632.0Topological domainCytoplasmic
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717562_571332616.0Topological domainCytoplasmic
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717593_596332616.0Topological domainLumenal
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717618_631332616.0Topological domainCytoplasmic
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817541_561364632.0TransmembraneHelical
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817572_592364632.0TransmembraneHelical
TgeneRPN2chr3:112738389chr20:35852281ENST00000237530817597_617364632.0TransmembraneHelical
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717541_561332616.0TransmembraneHelical
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717572_592332616.0TransmembraneHelical
TgeneRPN2chr3:112738389chr20:35852281ENST00000373622717597_617332616.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC3orf17chr3:112738389chr20:35852281ENST00000314400-19442_46035568.0RegionNuclear localization signal
HgeneC3orf17chr3:112738389chr20:35852281ENST00000383675-17442_46035498.0RegionNuclear localization signal
TgeneRPN2chr3:112738389chr20:35852281ENST0000023753081723_540364632.0Topological domainLumenal
TgeneRPN2chr3:112738389chr20:35852281ENST0000037362271723_540332616.0Topological domainLumenal


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Fusion Gene Sequence for C3orf17-RPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11703_11703_1_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000237530_length(transcript)=1406nt_BP=298nt
AATATACAGATGACTGGGTCCTTCCCAGTCCCACGCGTTTACTCGATGAAGGCAGCCTCCCGCCGGGCTCCTGGCCCCGCCCGAGCCCCA
CCCCCTGCTCCCTTCCGGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTC
CCCCCGCCTCGCATGATGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTG
ACAGTGCAGAACCCCGGCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAA
GGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGC
CTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCA
GGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGC
CTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTT
CCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAA
GAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGC
CAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGAC
TCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGC
AGTCAAGAGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTA
TGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCA
ACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTG

>11703_11703_1_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=268AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN

--------------------------------------------------------------
>11703_11703_2_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000373622_length(transcript)=1454nt_BP=298nt
AATATACAGATGACTGGGTCCTTCCCAGTCCCACGCGTTTACTCGATGAAGGCAGCCTCCCGCCGGGCTCCTGGCCCCGCCCGAGCCCCA
CCCCCTGCTCCCTTCCGGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTC
CCCCCGCCTCGCATGATGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTG
ACAGTGCAGAACCCCGGCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAA
GGATCAGAGCATTGCACCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGC
CTTGTTCTTCCAGCTGGTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCA
GGAAGTGGTGTTTGTTGCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGC
CTCTGGCACCTACACTCTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTT
CCCTGAGGAAGAAGCTCCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAA
GAGGCCCCCCACCGTGGTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGC
CAATGTCTCCAACTTCACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGAC
TCAGCTCAACATGTTCCAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGC
AGTCAAGAGGATCGCTGCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAAGATGGAAA
TTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAA
AAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTC
TGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAAATGTGTAATTGTTTTGGAATAAAGAG

>11703_11703_2_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000314400_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=284AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN
TFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRIAAEQ

--------------------------------------------------------------
>11703_11703_3_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000237530_length(transcript)=1300nt_BP=192nt
GGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTCCCCCCGCCTCGCATGA
TGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTGACAGTGCAGAACCCCG
GCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCA
CCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTG
GTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTT
GCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACT
CTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCT
CCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTG
GTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTC
ACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTC
CAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGAACAGCA
CATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATGTCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGA
AAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTAGTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACC
TGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAAGCTGTGAATATTCCTAACTTACCCAGATGTTGCTTTTGAAAAGTTGAA

>11703_11703_3_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000237530_length(amino acids)=268AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN

--------------------------------------------------------------
>11703_11703_4_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000373622_length(transcript)=1348nt_BP=192nt
GGCCCGGACTGGGTCCCATCGCCCCACCTCCGGTCGCTGGACGTGCTCTCGCGTAGCTCCGCCTTTCGTAAGTCCCCCCGCCTCGCATGA
TGGCTGCGGTGCCGCCGGGCCTGGAGCCGTGGAACCGTGTGAGAATCCCTAAGGCGGGGAACCGCAGCGCAGTGACAGTGCAGAACCCCG
GCGCGGCCCTTGCTCAGAGTCAAGATCTCCACTGAAGTTGGCATCACAAATGTTGATCTTTCCACCGTGGATAAGGATCAGAGCATTGCA
CCCAAAACTACCCGGGTGACATACCCAGCCAAAGCCAAGGGCACATTCATCGCAGACAGCCACCAGAACTTCGCCTTGTTCTTCCAGCTG
GTAGATGTGAACACTGGTGCTGAACTCACTCCTCACCAGACATTTGTCCGACTCCATAACCAGAAGACTGGCCAGGAAGTGGTGTTTGTT
GCCGAGCCAGACAACAAGAACGTGTACAAGTTTGAACTGGATACCTCTGAAAGAAAGATTGAATTTGACTCTGCCTCTGGCACCTACACT
CTCTACTTAATCATTGGAGATGCCACTTTGAAGAACCCAATCCTCTGGAATGTGGCTGATGTGGTCATCAAGTTCCCTGAGGAAGAAGCT
CCCTCGACTGTCTTGTCCCAGAACCTTTTCACTCCAAAACAGGAAATTCAGCACCTGTTCCGCGAGCCTGAGAAGAGGCCCCCCACCGTG
GTGTCCAATACATTCACTGCCCTGATCCTCTCGCCGTTGCTTCTGCTCTTCGCTCTGTGGATCCGGATTGGTGCCAATGTCTCCAACTTC
ACTTTTGCTCCTAGCACGATTATATTTCACCTGGGACATGCTGCTATGCTGGGACTCATGTATGTCTACTGGACTCAGCTCAACATGTTC
CAGACCTTGAAGTACCTGGCCATCCTGGGCAGTGTGACGTTTCTGGCTGGCAATCGGATGCTGGCCCAGCAGGCAGTCAAGAGGATCGCT
GCAGAGCAGAGCAGTAGATTGGCAAAATATAGGACACTACGAACAGCACATTAGTTCCAGAAGAAAGATGGAAATTCTGAAAACTGAATG
TCAAGAAAAGGAGTCAAGAACAATTCACAGTATGAGAAGAAAAATGGAAAAAAAAAACTTTATTTAAAAAAGAAAAAAGTCCAGATTGTA
GTTATACTTTTGCTTGTTTTTCAGTTTCCCCAACACACAGCAGATACCTGGTGAGCTCAGATAGTCTCTTTCTCTGACACTGTGTAAGAA

>11703_11703_4_C3orf17-RPN2_C3orf17_chr3_112738389_ENST00000383675_RPN2_chr20_35852281_ENST00000373622_length(amino acids)=284AA_BP=1
MLRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEP
DNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSN
TFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRIAAEQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for C3orf17-RPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C3orf17-RPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C3orf17-RPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0376358Malignant neoplasm of prostate1CTD_human