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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATL3-ZDHHC14 (FusionGDB2 ID:HG25923TG79683)

Fusion Gene Summary for ATL3-ZDHHC14

check button Fusion gene summary
Fusion gene informationFusion gene name: ATL3-ZDHHC14
Fusion gene ID: hg25923tg79683
HgeneTgene
Gene symbol

ATL3

ZDHHC14

Gene ID

25923

79683

Gene nameatlastin GTPase 3zinc finger DHHC-type palmitoyltransferase 14
SynonymsHSN1FNEW1CP
Cytomap('ATL3')('ZDHHC14')

11q13.1

6q25.3

Type of geneprotein-codingprotein-coding
Descriptionatlastin-3probable palmitoyltransferase ZDHHC14DHHC-14NEW1 domain-containing proteinzinc finger DHHC domain-containing protein 14zinc finger DHHC-type containing 14zinc finger, DHHC domain containing 14
Modification date2020031320200313
UniProtAcc

Q6DD88

.
Ensembl transtripts involved in fusion geneENST00000332645, ENST00000398868, 
ENST00000535789, ENST00000538786, 
Fusion gene scores* DoF score6 X 7 X 3=12611 X 12 X 9=1188
# samples 716
** MAII scorelog2(7/126*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(16/1188*10)=-2.8923910259134
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATL3 [Title/Abstract] AND ZDHHC14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATL3(63438762)-ZDHHC14(158068291), # samples:3
Anticipated loss of major functional domain due to fusion event.ATL3-ZDHHC14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL3-ZDHHC14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATL3-ZDHHC14 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ATL3-ZDHHC14 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATL3

GO:0051260

protein homooligomerization

18270207

TgeneZDHHC14

GO:0018345

protein palmitoylation

23034182


check buttonFusion gene breakpoints across ATL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZDHHC14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-BF-A1Q0-01AATL3chr11

63438762

-ZDHHC14chr6

158068291

+


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Fusion Gene ORF analysis for ATL3-ZDHHC14

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000332645ENST00000341375ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
5CDS-3UTRENST00000398868ENST00000341375ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
5UTR-3CDSENST00000535789ENST00000359775ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
5UTR-3CDSENST00000535789ENST00000414563ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
5UTR-3UTRENST00000535789ENST00000341375ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
Frame-shiftENST00000332645ENST00000359775ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
Frame-shiftENST00000332645ENST00000414563ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
In-frameENST00000398868ENST00000359775ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
In-frameENST00000398868ENST00000414563ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
intron-3CDSENST00000538786ENST00000359775ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
intron-3CDSENST00000538786ENST00000414563ATL3chr11

63438762

-ZDHHC14chr6

158068291

+
intron-3UTRENST00000538786ENST00000341375ATL3chr11

63438762

-ZDHHC14chr6

158068291

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000398868ATL3chr1163438762-ENST00000414563ZDHHC14chr6158068291+1713323260889209
ENST00000398868ATL3chr1163438762-ENST00000359775ZDHHC14chr6158068291+5959323260934224

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398868ENST00000414563ATL3chr1163438762-ZDHHC14chr6158068291+0.419133780.5808662
ENST00000398868ENST00000359775ATL3chr1163438762-ZDHHC14chr6158068291+0.203491850.79650813

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Fusion Genomic Features for ATL3-ZDHHC14


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ATL3chr1163438761-ZDHHC14chr6158068290+0.0111206130.9888793
ATL3chr1163438761-ZDHHC14chr6158068290+0.0111206130.9888793

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ATL3-ZDHHC14


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:63438762/chr6:158068291)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATL3

Q6DD88

.
FUNCTION: GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-11357_30515542.0DomainGB1/RHD3-type G
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113114_11615542.0Nucleotide bindingGTP
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113213_21415542.0Nucleotide bindingGTP
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113272_27515542.0Nucleotide bindingGTP
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-11367_7415542.0Nucleotide bindingGTP
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-1131_44515542.0Topological domainCytoplasmic
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113467_46715542.0Topological domainLumenal
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113489_54115542.0Topological domainCytoplasmic
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113446_46615542.0TransmembraneHelical
HgeneATL3chr11:63438762chr6:158068291ENST00000398868-113468_48815542.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559165_215285489.0DomainDHHC
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359165_215285474.0DomainDHHC
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559111_208285489.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST00000359775591_60285489.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559230_255285489.0Topological domainLumenal
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559277_488285489.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST000003597755982_89285489.0Topological domainLumenal
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359111_208285474.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST00000414563591_60285474.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359230_255285474.0Topological domainLumenal
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359277_488285474.0Topological domainCytoplasmic
TgeneZDHHC14chr11:63438762chr6:158068291ENST000004145635982_89285474.0Topological domainLumenal
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559209_229285489.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000035977559256_276285489.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST000003597755961_81285489.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST000003597755990_110285489.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359209_229285474.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST0000041456359256_276285474.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST000004145635961_81285474.0TransmembraneHelical
TgeneZDHHC14chr11:63438762chr6:158068291ENST000004145635990_110285474.0TransmembraneHelical


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Fusion Gene Sequence for ATL3-ZDHHC14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7656_7656_1_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000359775_length(transcript)=5959nt_BP=323nt
ACACGCGGCAGGCGGTGGCGGGATTCTGCCGCGTGCGCTTTCCCGCCCCGCCTCGCCTAGCCTCGTCCTGCGCTCGCCACGCCTCGGGCT
GTCCGTTGGGCCACGCAGACCGCGCTGCGCTCGCTCCGTCGCGGCTCCGCGTGCCCCACCTTCTGGCTAGTTTTTTCTAGAGCCCAGGCT
CCGCCCGTTTCCCGCTTCCAGGGCCCGGTTCGTTCCCGCCCGCACCCGTCCCTCTCCTCTGCACCCCTGCTGCTTCTGCTTTGAAGGCGG
AGGCTCCATGTTGTCCCCTCAGCGAGTGGCAGCAGCTGCCTCAAGAGGAGCAGATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAA
ATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAG
GGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGTGCG
ACCAAGACCAGTGCATTCAGAGCACCAAATTCGTTTTGCAGGCTGCAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACG
AGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCAGCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACC
TCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGCACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCC
CCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCATGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACT
CTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACATGGCCCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAGGAGT
GAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATGCCACGGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACTTAGG
ATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTTTCATTTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGGAAAT
AGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGGAATCGGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGCTTCT
GACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGCTACTAATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAAAAAA
AAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTGCATGCCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAAGGAA
GTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCAAGTGCTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGGACAG
TGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAGGTGGCACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGGGTGT
CACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTTGAGATATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGTGATG
AAACTTCCCGTGGACAGCCAATAAAATGACGTCCTCTGTTATTTTGGATCTGCGTACGGTTATCCTTAATAGCATAAATGAAAACAAAGT
CATCCAGATGGGGAGAGTTTTTCTTGAAATGTCCCTAGCGAGGAATGGTCCCCAGACAACCAAAAGTCAAATCTTTGAACTGGGAGATAT
TTATAGAATAATTTCTTAGATAAGAGGCAAGTTTTCCATCATTTATTTTCTTTAATTATCTCTTTTTGACACCATCTTAGTGGAATTTGC
TCTACGTTTGCAGTTTGCCGTGCAACAGTTGATCGGAAGTAGGGAGAGGGGAGGGGACGCTCAGGGAGAAGGTTCTGTCGGGCGTCTTCT
GGGCTTCCTTCTGTGTTAACGTGTCACTCAATCCCAGAAGTGCAACTTGAGGTCCTAGTAAAGGTATCAGAAAATGAGGAGGAGAAATCG
GCTTACAGTCTAAGCTGAGATCATGTAGGTCATCATCCTTCCTAGACACTGATCAGAATGAAATTAAGAAAATGACCACTTTGTTCACTT
TCATTGGTCACCTAGAAGGGAACGAACTGGCTCTGGACTTAGGGAGTGTGTCACTATGGGGGCAGCCACAGGGGACACAGCAACTCCTCT
CCTGGCTTCTTTCCAGACCATAAATCTAACAGCTAAAGCTACTCAAGTTCAAAGCCATGGCCTTGCTCCTTATAACCATATGAAAGACAA
GACACATTGACCAATGATACAAGTAACCCAAGTGATTTGCATTTATGGAAAAAGGCTATTACTCCTGAGAAAGAGTTGCCATTTTATATA
AAAGAAAAGAAGATAGGAAAAAGAAAAGCACACAAGTTTTATTTGGAATGAAGGCAATTCACAGGTCACAAAATAATTCATGCTGAAAGG
GCCTGCAGAGTTCTTGCACTGTGATGTCTTCGAGCCATCTTTATTGTCATGCTGCATGCACGTATAGAAAATGGAATAGGTCCATTCTAT
GTAGCCATTTTTGATTTTCTGAACCACCTAACTACTTGTACCCACCTGCAATGTGTAATTCATGGGGCAGTGCCCTCCTTACACAACCGC
ACACGCTCACAGGCACCAACTCACAGGGATTCTCCTTGTCCACGCTACCTGTGAGCCCAAAGTGACAGCCCCACAAAGGAGCTTCCACAA
CTTCCCAAACCGTCTCTGCTCCTTGCTTTCTTCCACCTGCTCCCCAGAGGCCCCAGGAAGGAGTTGGCCCTGATGAGAACGGTGCTCCAT
GGGTGACCGCGAATCCGGCTTAGCCCTCACTCCGGTCCCACGTGTGGCCCAGTCCATTCTCAGCTCATTCCCCTGGAAAGCAAGATCATG
GTCTTCAGAGGCCTCCCGCTTCTAACATTTCCTAACTCAGTGGTTGCCACTCTCCTGTGACCAGCCCTTCTTCCCACCTCACTGTGAAAA
ATTCCCAGAAGCCAGGATCACGACTCACTTGTCTTCACATAATGGATATTTACTTAATATTTATTATCAATTTCCCCACCTCCAACCCTG
TCCCTGGCACACACTTGGCATCATTTATCCAATAGGGGACTGGGAATTTTGGTGAAGTGAATCAAGGCTATTCAGGGTCAAGAGAGAGAT
TAACTTGAATGGGCCAATTTGCTAGATAATTAATGTCTTAAAAACCAAAACCAGAGAGAAGCCCACAGCCCTGTCCTCTGTGGCTTGAAA
AAGAAACCCAGCATCAGAGGAATGAGCGATGATGCCCCCTGGGGCGCCCACTTCTGTTTGTCAGGAGGGATGGTCGGAGGGGCAGCTCAC
CTGGCGAGGTGATGGCTCTGCATTTCCCACGAACATATATGTGACATGTACATAAATATAAATACTTATGTTTATAAATGTTGAATGGTT
CCTTCTAGCTGTGGCTGAGTAGACGTTGGTGTTTCTAACTTCTTTCAGTGTGTTAGAGATTGATTACATGCTAGCTATAAAAAGTAAAAT
AAATATTTTACCATGCTATTAAAGCTTGGACCATTATCAAACACACACAAACACACACTCATTCTGCTGTTTAAAAATTCATCTGCGTTC
GTTCTCCCAGGAGTGCTCCAGGGAACCACAGGCTTCCCGGCACTTGAAGGCTGAACTGAGCGTGAGTGCCCTGGTCCCCAGGAAGCAGGC
GGATGCTGCAGGAAGGTGGCAGACAGCCTGCATCCAGGAGGGCCCCAGGAAGTGGGGATGCTGCAGGAAGGCGGCACAAAGCCTGCATCC
GGGAGGGCCCCAGGAAGCAGGGGGATGCTGCAGGAAGGTGGCAGACAGACTGCATCCAGGAGGGCACAGTGACCTGTCACTCCGTTCTGC
AGAAATTGGCCCAGCAGTTGCGTTATGCCCAACCAAAAGATGCTCGTTCCAGCTTTCAAATGTGATGATTTCAGCCTGTGAGGACAATGC
CATGTCCCCACCCTAAGCCAGCAAAATGCGAAATCTCTGTTCTGGCCCAGAATGGCACAAGGGAGGAGTCTTTGCAGAGTTCCACGCCAC
CCCCCAGCTTACTGCGGCCTTCACCGGCTCTGTCTAGGATTGCCAGCTGTGGTTCCAAGTGAGGAGCAAACCCATTTTATGAGCCATGTT
CCTGCGGAGACCTGATGGGCCAGGCCTTCTGTGGCTTTGAAAACCCCTAAGCTCTTCACCTCCTGGGCCTAGGCCTTCTTGTCTGACTCA
ACAGCAAGAAAAATGAACTTGCCAAAATTGGCAGTAGGTGTCCTTGACACAGGGGCTTCTGATGGCATCGCCCAGAAAATGCTGGAACCA
GAACTGGTCAGAGACTTTGAAGGGCACAGCCTGGCGGGCTACTCCCCAAGGGTCTCAGGTCTCTGCCCACCTGACTACCCTGCAGCAAAC
GCTTCTCTGTAACCTGACTTCTCCCTTCAGACCTCAGCCTACAACCATCCTCTTCATGCCAGGAACCAACTGCTTCTCAGCCTCGGCTTA
GGGTCTTAAGTTCACCAGAAGGGATCGGGGTTTGCGTTGATATTATAAGGAATCTTCCCAGAAGGAGCTGCCCTTCATCCATCCACAAGA
ATACATTGAGTTCATTTAGTTCTTGACCAGGTAAGAAAAGAATAAAGGAGAACAAATATTAAATACTCTTTTCTAATTGATGCCTTACTA
CTGTTTTGAAGCTGAGCCGAAATCAAATTGATGTTTACATTTTCTATCAAGTACACATGAGCTGTGGGAGTCTAGCATATTCTTGTCCAA
AAGAGAGAGACTTTCAAATGAATTCCTATTCCTCTTGGTCCCCTCCACCTATTTTGGAGGTCTGCATGTGGAGTTGTATGCTATTTTCCA
AGGTACCTCATTTAAAAAAAAAAAAAAAAAAAAACTGCCTCTCATTTGTTCCCTTAAAACGTCTCTCTCTCTCATAAAACTAAGTTATCA
TTGAAATATTAAACGATCTGAAGCGTCTTTTTTTTTTTCAAATAAATGTCAAAGATGGTAATAGTTTGTAAATCAGTAAATCCTCTGTCC
ATCTGCCCATTGTCCATGGTCCTGATAATAGAGCCAAGATGGATTTTCACATGTAAGGTGTTAGTCCATTAATCCAGCCATTAAAAGTAG
TTGGGAGATTGAAGATTAGATGGTTTCTGGAGCAACCGAATTTGCAGCTGCCACAAAACTAGATAAATAGCCACAACTGGAGTTATTTTT
TGATCTCATAAACCCCAGGAATTACACACAGAATGGATTGAAAAGCAGACAAGCATCTTGTGCTATTGCAGAGACTTTTCTACCCAGGAA
GTGTTGAATTTTTAAAAGAAACTTGATATTGGTGATAAAGGTATGAATGAACAACTCTCTTACTTGCCCTCGATGTTTCAAGATGCCTGG
TGAAACCGAGAGGCCACATGGCATGTCCAAGGAGACATGCTTTCTGGGTTCTATATGAATAGAGATGGTTTTAGCCTGCAATTAAAAAAA
AAAAAAAAAACGGTTGAAGCCTTGCTAACTTTTTCCCAGAGCATTCTGGGTTGATATTTCACAGTCAAACGTTTTGGCATGGAAAAAAAA
AAAAGCATTTTAAACTCTTAGTGAATTCAAAGCTCTAAATCCAAACAATGGTGAACACATGTACATAACATTTCATGTTTTCAGAGATAC
GTATGCTTATTTAAGTGCCTTTCATGTTTTAATCAATGTTTGCAGAATTTATCTTAAACCTGAGATGAATTAAAAAATTTTTCTCCTTCA

>7656_7656_1_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000359775_length(amino acids)=224AA_BP=20
MKAEAPCCPLSEWQQLPQEEQIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQS
DMCDQDQCIQSTKFVLQAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEA

--------------------------------------------------------------
>7656_7656_2_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000414563_length(transcript)=1713nt_BP=323nt
ACACGCGGCAGGCGGTGGCGGGATTCTGCCGCGTGCGCTTTCCCGCCCCGCCTCGCCTAGCCTCGTCCTGCGCTCGCCACGCCTCGGGCT
GTCCGTTGGGCCACGCAGACCGCGCTGCGCTCGCTCCGTCGCGGCTCCGCGTGCCCCACCTTCTGGCTAGTTTTTTCTAGAGCCCAGGCT
CCGCCCGTTTCCCGCTTCCAGGGCCCGGTTCGTTCCCGCCCGCACCCGTCCCTCTCCTCTGCACCCCTGCTGCTTCTGCTTTGAAGGCGG
AGGCTCCATGTTGTCCCCTCAGCGAGTGGCAGCAGCTGCCTCAAGAGGAGCAGATTAAAGGATCCTGGTCAAATAAAAGAGGTAAAGAAA
ATTACAATCCCTACAGCTACGGAAATATCTTTACCAACTGCTGTGTTGCCCTGTGTGGGCCCATCTCACCAAGCCTGATCGACAGAAGAG
GGTACATCCAGCCCGACACGCCGCAGCCAGCAGCACCCTCCAATGGCATCACCATGTACGGGGCCACGCAGTCACAGAGTGACATGGCTG
CAGCCACGCCCCTGCTGCAGAGCGAGCCCAGCCTCACCAGCGACGAGCTGCACCTGCCCGGGAAGCCTGGCCTGGGCACGCCCTGCGCCA
GCCTCACACTGGGCCCGCCCACACCGCCCGCCTCCATGCCCAACCTCGCCGAGGCCACGCTCGCGGACGTGATGCCCCGGAAAGATGAGC
ACATGGGCCACCAGTTCCTGACGCCCGATGAGGCGCCCTCGCCCCCCAGGCTACTGGCGGCGGGCAGCCCCCTGGCGCACAGCCGCACCA
TGCACGTGCTGGGCCTGGCCAGCCAGGACTCCCTGCATGAGGACTCTGTGCGCGGCCTGGTGAAGCTCAGCTCCGTGTGACCCACATGGC
CCCAGGCCGGGGGACACCAGAGGCTCCTCCATGGGCAGCAGGAGTGAGCGGAGGGGTGTGTCCCACAGCGACTTTCCCAGCCAATGCCAC
GGTGGAGATGACAGCCCCAGGTCTGGGGTACAGAGACCACTTAGGATGGCACAGGGTGGCTGGCCCCGGATGCTGAGAGCTTGGTTTCAT
TTGAATTTTCTTCCCCAACCTGAGTGCTTTGACAACAATGGAAATAGAGAAGTGGCTGCTTTCTTTTGGTGACCCTCCAGGGGTGGAATC
GGAGTGTGTCTGCCCGCCCTTGTGACAGACACACGGAAGGCTTCTGACGCTTGTGGCCAGACTGCAATTGCACTTATGTGTTATGCTACT
AATATTTGAAACAGACCTGCCATTCCATTTGTTAATTAAAAAAAAAAAAAATCCTAAAGGGAAAAAACCGACCAGGTGTGGATCTGCATG
CCACGCTGCCGTCTGTGTTACAGTGGTGTTGCTATTTCCAAGGAAGTGCTGCTTTCTTTTTCTTTTTTTAATTTTGTGAATTTTCAAGTG
CTGTTTTGTTGGAAGACAGTGCAACGAACTGAGACTAATGGACAGTGTCATCACTCAGCTTACTGGGCTGAGGCGTCTGTGGAGAGGTGG
CACCGGGGCTGCAGAGGGCGGCTGGGGTTCCGTCGTGTCGGGTGTCACTTCACCTTCTGTTTGGCCGCTCGATGAGGTCTCGTGTTGAGA
TATTGTGTGCCACAACCCCCACAGTCTTCACCTCCGTGTGTGATGAAACTTCCCGTGGACAGCCAATAAAATGACGTCCTCTGTTATTTT

>7656_7656_2_ATL3-ZDHHC14_ATL3_chr11_63438762_ENST00000398868_ZDHHC14_chr6_158068291_ENST00000414563_length(amino acids)=209AA_BP=20
MKAEAPCCPLSEWQQLPQEEQIKGSWSNKRGKENYNPYSYGNIFTNCCVALCGPISPSLIDRRGYIQPDTPQPAAPSNGITMYGATQSQS
DMAAATPLLQSEPSLTSDELHLPGKPGLGTPCASLTLGPPTPPASMPNLAEATLADVMPRKDEHMGHQFLTPDEAPSPPRLLAAGSPLAH

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Fusion Gene PPI Analysis for ATL3-ZDHHC14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATL3-ZDHHC14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATL3-ZDHHC14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneATL3C0020071Hereditary Sensory Autonomic Neuropathy, Type 11ORPHANET
HgeneATL3C3810194NEUROPATHY, HEREDITARY SENSORY, TYPE IF1CTD_human;GENOMICS_ENGLAND;UNIPROT