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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:WWTR1-ATR (FusionGDB2 ID:HG25937TG545)

Fusion Gene Summary for WWTR1-ATR

check button Fusion gene summary
Fusion gene informationFusion gene name: WWTR1-ATR
Fusion gene ID: hg25937tg545
HgeneTgene
Gene symbol

WWTR1

ATR

Gene ID

25937

545

Gene nameWW domain containing transcription regulator 1ATR serine/threonine kinase
SynonymsTAZFCTCS|FRP1|MEC1|SCKL|SCKL1
Cytomap('WWTR1')('ATR')

3q25.1

3q23

Type of geneprotein-codingprotein-coding
DescriptionWW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motifserine/threonine-protein kinase ATRFRAP-related protein-1MEC1, mitosis entry checkpoint 1, homologataxia telangiectasia and Rad3-related protein
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000360632, ENST00000465804, 
ENST00000467467, ENST00000474080, 
Fusion gene scores* DoF score12 X 10 X 6=7209 X 8 X 5=360
# samples 1210
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/360*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: WWTR1 [Title/Abstract] AND ATR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointWWTR1(149374663)-ATR(142168444), # samples:3
Anticipated loss of major functional domain due to fusion event.WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
WWTR1-ATR seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneWWTR1

GO:0008284

positive regulation of cell proliferation

18227151

HgeneWWTR1

GO:0010718

positive regulation of epithelial to mesenchymal transition

18227151

HgeneWWTR1

GO:0017145

stem cell division

18568018

HgeneWWTR1

GO:0035329

hippo signaling

18227151|20412773

HgeneWWTR1

GO:0060390

regulation of SMAD protein signal transduction

18568018

TgeneATR

GO:0000077

DNA damage checkpoint

14657349

TgeneATR

GO:0006974

cellular response to DNA damage stimulus

27723717|27723720

TgeneATR

GO:0018105

peptidyl-serine phosphorylation

9733515

TgeneATR

GO:0046777

protein autophosphorylation

9733515

TgeneATR

GO:0071480

cellular response to gamma radiation

9925639


check buttonFusion gene breakpoints across WWTR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ATR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VN-A88M-01AWWTR1chr3

149374663

-ATRchr3

142168444

-
ChimerDB4PRADTCGA-VN-A88MWWTR1chr3

149374662

-ATRchr3

142168444

-
ChimerDB4PRADTCGA-VN-A88MWWTR1chr3

149374663

-ATRchr3

142168444

-


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Fusion Gene ORF analysis for WWTR1-ATR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000360632ENST00000350721WWTR1chr3

149374663

-ATRchr3

142168444

-
Frame-shiftENST00000360632ENST00000350721WWTR1chr3

149374662

-ATRchr3

142168444

-
Frame-shiftENST00000360632ENST00000383101WWTR1chr3

149374663

-ATRchr3

142168444

-
Frame-shiftENST00000360632ENST00000383101WWTR1chr3

149374662

-ATRchr3

142168444

-
Frame-shiftENST00000465804ENST00000350721WWTR1chr3

149374663

-ATRchr3

142168444

-
Frame-shiftENST00000465804ENST00000350721WWTR1chr3

149374662

-ATRchr3

142168444

-
Frame-shiftENST00000465804ENST00000383101WWTR1chr3

149374663

-ATRchr3

142168444

-
Frame-shiftENST00000465804ENST00000383101WWTR1chr3

149374662

-ATRchr3

142168444

-
In-frameENST00000467467ENST00000350721WWTR1chr3

149374663

-ATRchr3

142168444

-
In-frameENST00000467467ENST00000350721WWTR1chr3

149374662

-ATRchr3

142168444

-
In-frameENST00000467467ENST00000383101WWTR1chr3

149374663

-ATRchr3

142168444

-
In-frameENST00000467467ENST00000383101WWTR1chr3

149374662

-ATRchr3

142168444

-
intron-3CDSENST00000474080ENST00000350721WWTR1chr3

149374663

-ATRchr3

142168444

-
intron-3CDSENST00000474080ENST00000350721WWTR1chr3

149374662

-ATRchr3

142168444

-
intron-3CDSENST00000474080ENST00000383101WWTR1chr3

149374663

-ATRchr3

142168444

-
intron-3CDSENST00000474080ENST00000383101WWTR1chr3

149374662

-ATRchr3

142168444

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000467467WWTR1chr3149374663-ENST00000350721ATRchr3142168444-1002636205681158
ENST00000467467WWTR1chr3149374663-ENST00000383101ATRchr3142168444-1001636205681158
ENST00000467467WWTR1chr3149374662-ENST00000350721ATRchr3142168444-1002636205681158
ENST00000467467WWTR1chr3149374662-ENST00000383101ATRchr3142168444-1001636205681158

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000467467ENST00000350721WWTR1chr3149374663-ATRchr3142168444-0.063335650.9366644
ENST00000467467ENST00000383101WWTR1chr3149374663-ATRchr3142168444-0.0617585780.9382414
ENST00000467467ENST00000350721WWTR1chr3149374662-ATRchr3142168444-0.063335650.9366644
ENST00000467467ENST00000383101WWTR1chr3149374662-ATRchr3142168444-0.0617585780.9382414

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Fusion Genomic Features for WWTR1-ATR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for WWTR1-ATR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:149374663/chr3:142168444)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATRchr3:149374662chr3:142168444ENST0000035072145472612_264425872645.0DomainFATC
TgeneATRchr3:149374662chr3:142168444ENST0000038310144462612_264425232581.0DomainFATC
TgeneATRchr3:149374663chr3:142168444ENST0000035072145472612_264425872645.0DomainFATC
TgeneATRchr3:149374663chr3:142168444ENST0000038310144462612_264425232581.0DomainFATC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneWWTR1chr3:149374662chr3:142168444ENST00000360632-27225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374662chr3:142168444ENST00000465804-38225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374662chr3:142168444ENST00000467467-27225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374663chr3:142168444ENST00000360632-27225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374663chr3:142168444ENST00000465804-38225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374663chr3:142168444ENST00000467467-27225_259143401.0Coiled coilOntology_term=ECO:0000255
HgeneWWTR1chr3:149374662chr3:142168444ENST00000360632-27194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374662chr3:142168444ENST00000465804-38194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374662chr3:142168444ENST00000467467-27194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374663chr3:142168444ENST00000360632-27194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374663chr3:142168444ENST00000465804-38194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374663chr3:142168444ENST00000467467-27194_241143401.0Compositional biasNote=Gln-rich
HgeneWWTR1chr3:149374662chr3:142168444ENST00000360632-27124_157143401.0DomainWW
HgeneWWTR1chr3:149374662chr3:142168444ENST00000465804-38124_157143401.0DomainWW
HgeneWWTR1chr3:149374662chr3:142168444ENST00000467467-27124_157143401.0DomainWW
HgeneWWTR1chr3:149374663chr3:142168444ENST00000360632-27124_157143401.0DomainWW
HgeneWWTR1chr3:149374663chr3:142168444ENST00000465804-38124_157143401.0DomainWW
HgeneWWTR1chr3:149374663chr3:142168444ENST00000467467-27124_157143401.0DomainWW
TgeneATRchr3:149374662chr3:142168444ENST0000035072145471640_218525872645.0DomainFAT
TgeneATRchr3:149374662chr3:142168444ENST0000035072145472322_256725872645.0DomainPI3K/PI4K
TgeneATRchr3:149374662chr3:142168444ENST0000038310144461640_218525232581.0DomainFAT
TgeneATRchr3:149374662chr3:142168444ENST0000038310144462322_256725232581.0DomainPI3K/PI4K
TgeneATRchr3:149374663chr3:142168444ENST0000035072145471640_218525872645.0DomainFAT
TgeneATRchr3:149374663chr3:142168444ENST0000035072145472322_256725872645.0DomainPI3K/PI4K
TgeneATRchr3:149374663chr3:142168444ENST0000038310144461640_218525232581.0DomainFAT
TgeneATRchr3:149374663chr3:142168444ENST0000038310144462322_256725232581.0DomainPI3K/PI4K
TgeneATRchr3:149374662chr3:142168444ENST0000035072145471329_136525872645.0RepeatNote=HEAT 2
TgeneATRchr3:149374662chr3:142168444ENST000003507214547799_83525872645.0RepeatNote=HEAT 1
TgeneATRchr3:149374662chr3:142168444ENST0000038310144461329_136525232581.0RepeatNote=HEAT 2
TgeneATRchr3:149374662chr3:142168444ENST000003831014446799_83525232581.0RepeatNote=HEAT 1
TgeneATRchr3:149374663chr3:142168444ENST0000035072145471329_136525872645.0RepeatNote=HEAT 2
TgeneATRchr3:149374663chr3:142168444ENST000003507214547799_83525872645.0RepeatNote=HEAT 1
TgeneATRchr3:149374663chr3:142168444ENST0000038310144461329_136525232581.0RepeatNote=HEAT 2
TgeneATRchr3:149374663chr3:142168444ENST000003831014446799_83525232581.0RepeatNote=HEAT 1


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Fusion Gene Sequence for WWTR1-ATR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>99548_99548_1_WWTR1-ATR_WWTR1_chr3_149374662_ENST00000467467_ATR_chr3_142168444_ENST00000350721_length(transcript)=1002nt_BP=636nt
AGTCCGGGAGCTGCTGCGGCCGCGCTGTCTGCTTCTCCTGCGCCTCCTTTTCGCCCAGCACTAGCGCCTTAGGCCAGCTCGGGGGATGTG
AGAGCCGAAGCCCTTAGACTGCCAGGCACAGAGTCGGGTCGGGATTTGTCAGCCAAGCCTCGGCTCCAGCTCCGCAATCTCGGGACTCAC
CCGAGCGACCCAGGCCCGACGGCAAATGAATCCGGCCTCGGCGCCCCCTCCGCTCCCGCCGCCTGGGCAGCAAGTGATCCACGTCACGCA
GGACCTAGACACAGACCTCGAAGCCCTCTTCAACTCTGTCATGAATCCGAAGCCTAGCTCGTGGCGGAAGAAGATCCTGCCGGAGTCTTT
CTTTAAGGAGCCTGATTCGGGCTCGCACTCGCGCCAGTCCAGCACCGACTCGTCGGGCGGCCACCCGGGGCCTCGACTGGCTGGGGGTGC
CCAGCATGTCCGCTCGCACTCGTCGCCCGCGTCCCTGCAGCTGGGCACCGGCGCGGGTGCTGCGGGTAGCCCCGCGCAGCAGCACGCGCA
CCTCCGCCAGCAGTCCTACGACGTGACCGACGAGCTGCCACTGCCCCCGGGCTGGGAGATGACCTTCACGGCCACTGGCCAGAGGTACTT
CCTCAAGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCT
ATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTTGGACTCCATATATGTGA
AATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTGTTCAATTCTAAAGTACA
ACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAGTTATTAAGAAATAAACT
GCTTTCTTAATA

>99548_99548_1_WWTR1-ATR_WWTR1_chr3_149374662_ENST00000467467_ATR_chr3_142168444_ENST00000350721_length(amino acids)=158AA_BP=
MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSS
PASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLKPRPMFLTLSSDYKV

--------------------------------------------------------------
>99548_99548_2_WWTR1-ATR_WWTR1_chr3_149374662_ENST00000467467_ATR_chr3_142168444_ENST00000383101_length(transcript)=1001nt_BP=636nt
AGTCCGGGAGCTGCTGCGGCCGCGCTGTCTGCTTCTCCTGCGCCTCCTTTTCGCCCAGCACTAGCGCCTTAGGCCAGCTCGGGGGATGTG
AGAGCCGAAGCCCTTAGACTGCCAGGCACAGAGTCGGGTCGGGATTTGTCAGCCAAGCCTCGGCTCCAGCTCCGCAATCTCGGGACTCAC
CCGAGCGACCCAGGCCCGACGGCAAATGAATCCGGCCTCGGCGCCCCCTCCGCTCCCGCCGCCTGGGCAGCAAGTGATCCACGTCACGCA
GGACCTAGACACAGACCTCGAAGCCCTCTTCAACTCTGTCATGAATCCGAAGCCTAGCTCGTGGCGGAAGAAGATCCTGCCGGAGTCTTT
CTTTAAGGAGCCTGATTCGGGCTCGCACTCGCGCCAGTCCAGCACCGACTCGTCGGGCGGCCACCCGGGGCCTCGACTGGCTGGGGGTGC
CCAGCATGTCCGCTCGCACTCGTCGCCCGCGTCCCTGCAGCTGGGCACCGGCGCGGGTGCTGCGGGTAGCCCCGCGCAGCAGCACGCGCA
CCTCCGCCAGCAGTCCTACGACGTGACCGACGAGCTGCCACTGCCCCCGGGCTGGGAGATGACCTTCACGGCCACTGGCCAGAGGTACTT
CCTCAAGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCT
ATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTTGGACTCCATATATGTGA
AATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTGTTCAATTCTAAAGTACA
ACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAGTTATTAAGAAATAAACT
GCTTTCTTAAT

>99548_99548_2_WWTR1-ATR_WWTR1_chr3_149374662_ENST00000467467_ATR_chr3_142168444_ENST00000383101_length(amino acids)=158AA_BP=
MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSS
PASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLKPRPMFLTLSSDYKV

--------------------------------------------------------------
>99548_99548_3_WWTR1-ATR_WWTR1_chr3_149374663_ENST00000467467_ATR_chr3_142168444_ENST00000350721_length(transcript)=1002nt_BP=636nt
AGTCCGGGAGCTGCTGCGGCCGCGCTGTCTGCTTCTCCTGCGCCTCCTTTTCGCCCAGCACTAGCGCCTTAGGCCAGCTCGGGGGATGTG
AGAGCCGAAGCCCTTAGACTGCCAGGCACAGAGTCGGGTCGGGATTTGTCAGCCAAGCCTCGGCTCCAGCTCCGCAATCTCGGGACTCAC
CCGAGCGACCCAGGCCCGACGGCAAATGAATCCGGCCTCGGCGCCCCCTCCGCTCCCGCCGCCTGGGCAGCAAGTGATCCACGTCACGCA
GGACCTAGACACAGACCTCGAAGCCCTCTTCAACTCTGTCATGAATCCGAAGCCTAGCTCGTGGCGGAAGAAGATCCTGCCGGAGTCTTT
CTTTAAGGAGCCTGATTCGGGCTCGCACTCGCGCCAGTCCAGCACCGACTCGTCGGGCGGCCACCCGGGGCCTCGACTGGCTGGGGGTGC
CCAGCATGTCCGCTCGCACTCGTCGCCCGCGTCCCTGCAGCTGGGCACCGGCGCGGGTGCTGCGGGTAGCCCCGCGCAGCAGCACGCGCA
CCTCCGCCAGCAGTCCTACGACGTGACCGACGAGCTGCCACTGCCCCCGGGCTGGGAGATGACCTTCACGGCCACTGGCCAGAGGTACTT
CCTCAAGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCT
ATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTTGGACTCCATATATGTGA
AATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTGTTCAATTCTAAAGTACA
ACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAGTTATTAAGAAATAAACT
GCTTTCTTAATA

>99548_99548_3_WWTR1-ATR_WWTR1_chr3_149374663_ENST00000467467_ATR_chr3_142168444_ENST00000350721_length(amino acids)=158AA_BP=
MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSS
PASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLKPRPMFLTLSSDYKV

--------------------------------------------------------------
>99548_99548_4_WWTR1-ATR_WWTR1_chr3_149374663_ENST00000467467_ATR_chr3_142168444_ENST00000383101_length(transcript)=1001nt_BP=636nt
AGTCCGGGAGCTGCTGCGGCCGCGCTGTCTGCTTCTCCTGCGCCTCCTTTTCGCCCAGCACTAGCGCCTTAGGCCAGCTCGGGGGATGTG
AGAGCCGAAGCCCTTAGACTGCCAGGCACAGAGTCGGGTCGGGATTTGTCAGCCAAGCCTCGGCTCCAGCTCCGCAATCTCGGGACTCAC
CCGAGCGACCCAGGCCCGACGGCAAATGAATCCGGCCTCGGCGCCCCCTCCGCTCCCGCCGCCTGGGCAGCAAGTGATCCACGTCACGCA
GGACCTAGACACAGACCTCGAAGCCCTCTTCAACTCTGTCATGAATCCGAAGCCTAGCTCGTGGCGGAAGAAGATCCTGCCGGAGTCTTT
CTTTAAGGAGCCTGATTCGGGCTCGCACTCGCGCCAGTCCAGCACCGACTCGTCGGGCGGCCACCCGGGGCCTCGACTGGCTGGGGGTGC
CCAGCATGTCCGCTCGCACTCGTCGCCCGCGTCCCTGCAGCTGGGCACCGGCGCGGGTGCTGCGGGTAGCCCCGCGCAGCAGCACGCGCA
CCTCCGCCAGCAGTCCTACGACGTGACCGACGAGCTGCCACTGCCCCCGGGCTGGGAGATGACCTTCACGGCCACTGGCCAGAGGTACTT
CCTCAAGCCAAGACCCATGTTCTTGACATTGAGCAGCGACTACAAGGTGTAATCAAGACTCGAAATAGAGTGACAGGACTGCCGTTATCT
ATTGAAGGACATGTGCATTACCTTATACAGGAAGCTACTGATGAAAACTTACTATGCCAGATGTATCTTGGTTGGACTCCATATATGTGA
AATGAAATTATGTAAAAGAATATGTTAATAATCTAAAAGTAATGCATTTGGTATGAATCTGTGGTTGTATCTGTTCAATTCTAAAGTACA
ACATAAATTTACGTTCTCAGCAACTGTTATTTCTCTCTGATCATTAATTATATGTAAAATAATATACATTCAGTTATTAAGAAATAAACT
GCTTTCTTAAT

>99548_99548_4_WWTR1-ATR_WWTR1_chr3_149374663_ENST00000467467_ATR_chr3_142168444_ENST00000383101_length(amino acids)=158AA_BP=
MNPASAPPPLPPPGQQVIHVTQDLDTDLEALFNSVMNPKPSSWRKKILPESFFKEPDSGSHSRQSSTDSSGGHPGPRLAGGAQHVRSHSS
PASLQLGTGAGAAGSPAQQHAHLRQQSYDVTDELPLPPGWEMTFTATGQRYFLKPRPMFLTLSSDYKV

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Fusion Gene PPI Analysis for WWTR1-ATR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for WWTR1-ATR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for WWTR1-ATR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneWWTR1C0026846Muscular Atrophy1CTD_human
HgeneWWTR1C0206655Alveolar rhabdomyosarcoma1CTD_human
HgeneWWTR1C0206732Epithelioid hemangioendothelioma1ORPHANET
HgeneWWTR1C0270948Neurogenic Muscular Atrophy1CTD_human
TgeneC3281203CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL2CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0004681Bagassosis1CTD_human
TgeneC0032273Pneumoconiosis1CTD_human
TgeneC0033578Prostatic Neoplasms1CTD_human
TgeneC0042076Urologic Neoplasms1CTD_human
TgeneC0265202Seckel syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC0376358Malignant neoplasm of prostate1CTD_human
TgeneC0751571Cancer of Urinary Tract1CTD_human
TgeneC4551474Seckel syndrome 11CTD_human;GENOMICS_ENGLAND