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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:C20orf194-TDRD10 (FusionGDB2 ID:HG25943TG126668)

Fusion Gene Summary for C20orf194-TDRD10

check button Fusion gene summary
Fusion gene informationFusion gene name: C20orf194-TDRD10
Fusion gene ID: hg25943tg126668
HgeneTgene
Gene symbol

C20orf194

TDRD10

Gene ID

25943

126668

Gene namechromosome 20 open reading frame 194tudor domain containing 10
Synonyms--
Cytomap('C20orf194')('TDRD10')

20p13

1q21.3

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized protein C20orf194tudor domain-containing protein 10
Modification date2020031320200313
UniProtAcc

Q5TEA3

.
Ensembl transtripts involved in fusion geneENST00000252032, ENST00000453730, 
ENST00000498079, 
Fusion gene scores* DoF score12 X 13 X 7=10923 X 3 X 4=36
# samples 135
** MAII scorelog2(13/1092*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: C20orf194 [Title/Abstract] AND TDRD10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC20orf194(3354695)-TDRD10(154514500), # samples:3
Anticipated loss of major functional domain due to fusion event.C20orf194-TDRD10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf194-TDRD10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf194-TDRD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C20orf194-TDRD10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across C20orf194 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TDRD10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A1FW-01AC20orf194chr20

3354695

-TDRD10chr1

154514500

+
ChimerDB4BRCATCGA-A2-A1FWC20orf194chr20

3354694

-TDRD10chr1

154514499

+


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Fusion Gene ORF analysis for C20orf194-TDRD10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000252032ENST00000479937C20orf194chr20

3354695

-TDRD10chr1

154514500

+
5CDS-3UTRENST00000252032ENST00000479937C20orf194chr20

3354694

-TDRD10chr1

154514499

+
In-frameENST00000252032ENST00000368480C20orf194chr20

3354695

-TDRD10chr1

154514500

+
In-frameENST00000252032ENST00000368480C20orf194chr20

3354694

-TDRD10chr1

154514499

+
In-frameENST00000252032ENST00000368482C20orf194chr20

3354695

-TDRD10chr1

154514500

+
In-frameENST00000252032ENST00000368482C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3CDSENST00000453730ENST00000368480C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3CDSENST00000453730ENST00000368480C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3CDSENST00000453730ENST00000368482C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3CDSENST00000453730ENST00000368482C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3CDSENST00000498079ENST00000368480C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3CDSENST00000498079ENST00000368480C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3CDSENST00000498079ENST00000368482C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3CDSENST00000498079ENST00000368482C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3UTRENST00000453730ENST00000479937C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3UTRENST00000453730ENST00000479937C20orf194chr20

3354694

-TDRD10chr1

154514499

+
intron-3UTRENST00000498079ENST00000479937C20orf194chr20

3354695

-TDRD10chr1

154514500

+
intron-3UTRENST00000498079ENST00000479937C20orf194chr20

3354694

-TDRD10chr1

154514499

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000252032C20orf194chr203354695-ENST00000368482TDRD10chr1154514500+1804680681366432
ENST00000252032C20orf194chr203354695-ENST00000368480TDRD10chr1154514500+2002680681411447
ENST00000252032C20orf194chr203354694-ENST00000368482TDRD10chr1154514499+1804680681366432
ENST00000252032C20orf194chr203354694-ENST00000368480TDRD10chr1154514499+2002680681411447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000252032ENST00000368482C20orf194chr203354695-TDRD10chr1154514500+0.0045741070.9954259
ENST00000252032ENST00000368480C20orf194chr203354695-TDRD10chr1154514500+0.0048590250.995141
ENST00000252032ENST00000368482C20orf194chr203354694-TDRD10chr1154514499+0.0045741070.9954259
ENST00000252032ENST00000368480C20orf194chr203354694-TDRD10chr1154514499+0.0048590250.995141

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Fusion Genomic Features for C20orf194-TDRD10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
C20orf194chr203354694-TDRD10chr1154514499+0.0001222390.9998777
C20orf194chr203354694-TDRD10chr1154514499+0.0001222390.9998777
C20orf194chr203354694-TDRD10chr1154514499+0.0001222390.9998777
C20orf194chr203354694-TDRD10chr1154514499+0.0001222390.9998777

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for C20orf194-TDRD10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:3354695/chr1:154514500)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
C20orf194

Q5TEA3

.
FUNCTION: May act as an effector for ARL3.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTDRD10chr20:3354694chr1:154514499ENST00000368480512216_237123367.0Coiled coilOntology_term=ECO:0000255
TgeneTDRD10chr20:3354694chr1:154514499ENST00000368482513216_237123352.0Coiled coilOntology_term=ECO:0000255
TgeneTDRD10chr20:3354695chr1:154514500ENST00000368480512216_237123367.0Coiled coilOntology_term=ECO:0000255
TgeneTDRD10chr20:3354695chr1:154514500ENST00000368482513216_237123352.0Coiled coilOntology_term=ECO:0000255
TgeneTDRD10chr20:3354694chr1:154514499ENST00000368480512210_317123367.0DomainNote=Tudor
TgeneTDRD10chr20:3354694chr1:154514499ENST00000368482513210_317123352.0DomainNote=Tudor
TgeneTDRD10chr20:3354695chr1:154514500ENST00000368480512210_317123367.0DomainNote=Tudor
TgeneTDRD10chr20:3354695chr1:154514500ENST00000368482513210_317123352.0DomainNote=Tudor

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTDRD10chr20:3354694chr1:154514499ENST0000036848051234_107123367.0DomainRRM
TgeneTDRD10chr20:3354694chr1:154514499ENST0000036848251334_107123352.0DomainRRM
TgeneTDRD10chr20:3354695chr1:154514500ENST0000036848051234_107123367.0DomainRRM
TgeneTDRD10chr20:3354695chr1:154514500ENST0000036848251334_107123352.0DomainRRM


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Fusion Gene Sequence for C20orf194-TDRD10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11481_11481_1_C20orf194-TDRD10_C20orf194_chr20_3354694_ENST00000252032_TDRD10_chr1_154514499_ENST00000368480_length(transcript)=2002nt_BP=680nt
GCCGCCCTGCGGGCAACTGAGACCCTCGCAGCTGCACCGTCCTCCTCCGCCGCCAGTCGTCCGCCGCCATGGACGTGTACCCCCCGCGCC
GGCAGGGGCTGCCCCGCGCTCGGTCCCCTGGCGGCTCCAGCCGCGGGTCACCCTCCGTCAGCTGCAGTCGACTTCGGCAGGTTCAGAGCA
TCCTGACCCAGAGCAGCAAGTCTCGGCCGGATGGGATCCTCTGCATCCTAGGAATCGATAGCAGGTACAATGAAGGCTGCAGAGAGCTGG
CAAATTATCTTCTATTTGGTTTGTACAATCAGAATACCAGTGATTTTGAGAAAACGGGATTTTCTGAAGAAGTACTAGATGATGTAATTA
TATTGATTAAATCGGATAGCGTCCATCTGTACTGTAATCCTGTAAACTTTCGCTATCTCTTACCTTATGTGGCACATTGGAGAAATCTGC
ATTTCCACTGCATGACCGAAAATGAGTATGAAGATGAAGAAGCCGCAGAAGAATTTAAAATTACCAGCTTTGTGGACATGGTTCGAGACT
GTAGTAGAATTGGCATTCCTTACAGCTCCCAAGGTCACTTGCAGATATTTGATATGTTTGTGGTGGAGAAATGGCCAATTGTACAGGCCT
TTGCACTTGAGGGCATTGGAGGGGATGGATTTTTTACCATGAAATATGAGGTGTTGGAGAAGGCTTCTGGTGAAGGATTTGGCAAAACCG
CCGCTATTATACAGCTCGCTCCTAAAGCTCCTGTTGACCTGTGTGAGACAGAGAAACTGAGGGCAGCCTTCTTTGCAGTCCCGTTGGAAA
TGAGAGGGTCCTTCCTGGTGCTGCTCCTGAGGGAATGCTTCCGAGACCTGAGCTGGCTGGCACTCATCCATAGCGTCCGTGGGGAGGCGG
GGCTGCTGGTGACGAGTATCGTCCCGAAGACCCCGTTTTTCTGGGCTATGCACGTCACTGAGGCTCTGCACCAGAACATGCAGGCTCTGT
TTAGCACCCTGGCTCAGGCGGAGGAGCAGCAGCCCTACCTGGAGGGCTCCACCGTTATGCGCGGGACTCGCTGTCTGGCAGAGTACCACC
TGGGGGATTATGGACACGCCTGGAACAGGTGTTGGGTGCTGGACAGGGTGGACACCTGGGCTGTGGTCATGTTCATTGATTTTGGACAGT
TGGCCACCATCCCTGTGCAGTCTCTGCGCAGCCTAGACAGCGACGACTTCTGGACCATCCCACCCCTGACTCAGCCATTCATGCTGGAGA
AAGACATTTTGAGTTCGTATGAGGTTGTCCATCGAATCCTCAAAGGGAAAATCACTGGTGCTTTGAACTCGGCGGTAACTGCTCCTGCAT
CTAACTTGGCTGTTGTCCCTCCACTCCTGCCCTTGGGGTGTCTGCAGCAGGCTGCTGCCTAGGCCTGGACACAGTATTTACCTGGCATTC
TTTTAGATCAAACGAACTGGTTATCTGAGGGGTTGGGTGAACTGGCTCGGGTGGGCCTTCCTTCCCACCAAGGCTTTGTCTTTCTCTTCC
AGTTGCACATCCTAAAGTTTGAAGAGTCTAAATAACGGGGCTTCCCTCAGCATGTTCCCTCTCCTGTTTGCCACGGATCCAGAGGCCACC
TGCCCTGTCTTCTCGTACCCCTTTCACTCTTGAGGCCTGGGAGGTGAAAAAGGCCAGACTGTGCCCAGGATTGATTCAATTTTGCTTTTA
CTCCCAGCTTCCCTCTCAAAAGAGAGTGAAGTCTCATTTGTCATGTGTCTTCAGTTCCCCAACTTGGCATGAACATTTGAACCAAACATA
GGAAACTACCATTAGGTTGAAAGCCTGAGGCAGCTGGGATGGTCTTTCTTGTGTCTCTTCTTTGCACCCCAGAGCATGATATAAGTGGTC
CTAACAGATTCTGGATAATGGAGAAGCCCTCTGCTGGTTTTCCTGGCATTCCATGTAGAATAGGTAGAGAATATTTAACCAATGAGCAAA
TAAATGTTGGCATGTTTCATGA

>11481_11481_1_C20orf194-TDRD10_C20orf194_chr20_3354694_ENST00000252032_TDRD10_chr1_154514499_ENST00000368480_length(amino acids)=447AA_BP=204
MDVYPPRRQGLPRARSPGGSSRGSPSVSCSRLRQVQSILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLFGLYNQNTSDFEKTGFSE
EVLDDVIILIKSDSVHLYCNPVNFRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKITSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVE
KWPIVQAFALEGIGGDGFFTMKYEVLEKASGEGFGKTAAIIQLAPKAPVDLCETEKLRAAFFAVPLEMRGSFLVLLLRECFRDLSWLALI
HSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAEYHLGDYGHAWNRCWVLDRVDTWAVV
MFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKITGALNSAVTAPASNLAVVPPLLPLGCLQQAAA

--------------------------------------------------------------
>11481_11481_2_C20orf194-TDRD10_C20orf194_chr20_3354694_ENST00000252032_TDRD10_chr1_154514499_ENST00000368482_length(transcript)=1804nt_BP=680nt
GCCGCCCTGCGGGCAACTGAGACCCTCGCAGCTGCACCGTCCTCCTCCGCCGCCAGTCGTCCGCCGCCATGGACGTGTACCCCCCGCGCC
GGCAGGGGCTGCCCCGCGCTCGGTCCCCTGGCGGCTCCAGCCGCGGGTCACCCTCCGTCAGCTGCAGTCGACTTCGGCAGGTTCAGAGCA
TCCTGACCCAGAGCAGCAAGTCTCGGCCGGATGGGATCCTCTGCATCCTAGGAATCGATAGCAGGTACAATGAAGGCTGCAGAGAGCTGG
CAAATTATCTTCTATTTGGTTTGTACAATCAGAATACCAGTGATTTTGAGAAAACGGGATTTTCTGAAGAAGTACTAGATGATGTAATTA
TATTGATTAAATCGGATAGCGTCCATCTGTACTGTAATCCTGTAAACTTTCGCTATCTCTTACCTTATGTGGCACATTGGAGAAATCTGC
ATTTCCACTGCATGACCGAAAATGAGTATGAAGATGAAGAAGCCGCAGAAGAATTTAAAATTACCAGCTTTGTGGACATGGTTCGAGACT
GTAGTAGAATTGGCATTCCTTACAGCTCCCAAGGTCACTTGCAGATATTTGATATGTTTGTGGTGGAGAAATGGCCAATTGTACAGGCCT
TTGCACTTGAGGGCATTGGAGGGGATGGATTTTTTACCATGAAATATGAGGTGTTGGAGAAGGCTTCTGGTGAAGGATTTGGCAAAACCG
CCGCTATTATACAGCTCGCTCCTAAAGCTCCTGTTGACCTGTGTGAGACAGAGAAACTGAGGGCAGCCTTCTTTGCAGTCCCGTTGGAAA
TGAGAGGGTCCTTCCTGGTGCTGCTCCTGAGGGAATGCTTCCGAGACCTGAGCTGGCTGGCACTCATCCATAGCGTCCGTGGGGAGGCGG
GGCTGCTGGTGACGAGTATCGTCCCGAAGACCCCGTTTTTCTGGGCTATGCACGTCACTGAGGCTCTGCACCAGAACATGCAGGCTCTGT
TTAGCACCCTGGCTCAGGCGGAGGAGCAGCAGCCCTACCTGGAGGGCTCCACCGTTATGCGCGGGACTCGCTGTCTGGCAGAGTACCACC
TGGGGGATTATGGACACGCCTGGAACAGGTGTTGGGTGCTGGACAGGGTGGACACCTGGGCTGTGGTCATGTTCATTGATTTTGGACAGT
TGGCCACCATCCCTGTGCAGTCTCTGCGCAGCCTAGACAGCGACGACTTCTGGACCATCCCACCCCTGACTCAGCCATTCATGCTGGAGA
AAGACATTTTGAGTTCGTATGAGGTTGTCCATCGAATCCTCAAAGGGAAAATCACTGGTGCTTTGAACTCGGCGTTGCACATCCTAAAGT
TTGAAGAGTCTAAATAACGGGGCTTCCCTCAGCATGTTCCCTCTCCTGTTTGCCACGGATCCAGAGGCCACCTGCCCTGTCTTCTCGTAC
CCCTTTCACTCTTGAGGCCTGGGAGGTGAAAAAGGCCAGACTGTGCCCAGGATTGATTCAATTTTGCTTTTACTCCCAGCTTCCCTCTCA
AAAGAGAGTGAAGTCTCATTTGTCATGTGTCTTCAGTTCCCCAACTTGGCATGAACATTTGAACCAAACATAGGAAACTACCATTAGGTT
GAAAGCCTGAGGCAGCTGGGATGGTCTTTCTTGTGTCTCTTCTTTGCACCCCAGAGCATGATATAAGTGGTCCTAACAGATTCTGGATAA
TGGAGAAGCCCTCTGCTGGTTTTCCTGGCATTCCATGTAGAATAGGTAGAGAATATTTAACCAATGAGCAAATAAATGTTGGCATGTTTC
ATGA

>11481_11481_2_C20orf194-TDRD10_C20orf194_chr20_3354694_ENST00000252032_TDRD10_chr1_154514499_ENST00000368482_length(amino acids)=432AA_BP=204
MDVYPPRRQGLPRARSPGGSSRGSPSVSCSRLRQVQSILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLFGLYNQNTSDFEKTGFSE
EVLDDVIILIKSDSVHLYCNPVNFRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKITSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVE
KWPIVQAFALEGIGGDGFFTMKYEVLEKASGEGFGKTAAIIQLAPKAPVDLCETEKLRAAFFAVPLEMRGSFLVLLLRECFRDLSWLALI
HSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAEYHLGDYGHAWNRCWVLDRVDTWAVV
MFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKITGALNSALHILKFEESK

--------------------------------------------------------------
>11481_11481_3_C20orf194-TDRD10_C20orf194_chr20_3354695_ENST00000252032_TDRD10_chr1_154514500_ENST00000368480_length(transcript)=2002nt_BP=680nt
GCCGCCCTGCGGGCAACTGAGACCCTCGCAGCTGCACCGTCCTCCTCCGCCGCCAGTCGTCCGCCGCCATGGACGTGTACCCCCCGCGCC
GGCAGGGGCTGCCCCGCGCTCGGTCCCCTGGCGGCTCCAGCCGCGGGTCACCCTCCGTCAGCTGCAGTCGACTTCGGCAGGTTCAGAGCA
TCCTGACCCAGAGCAGCAAGTCTCGGCCGGATGGGATCCTCTGCATCCTAGGAATCGATAGCAGGTACAATGAAGGCTGCAGAGAGCTGG
CAAATTATCTTCTATTTGGTTTGTACAATCAGAATACCAGTGATTTTGAGAAAACGGGATTTTCTGAAGAAGTACTAGATGATGTAATTA
TATTGATTAAATCGGATAGCGTCCATCTGTACTGTAATCCTGTAAACTTTCGCTATCTCTTACCTTATGTGGCACATTGGAGAAATCTGC
ATTTCCACTGCATGACCGAAAATGAGTATGAAGATGAAGAAGCCGCAGAAGAATTTAAAATTACCAGCTTTGTGGACATGGTTCGAGACT
GTAGTAGAATTGGCATTCCTTACAGCTCCCAAGGTCACTTGCAGATATTTGATATGTTTGTGGTGGAGAAATGGCCAATTGTACAGGCCT
TTGCACTTGAGGGCATTGGAGGGGATGGATTTTTTACCATGAAATATGAGGTGTTGGAGAAGGCTTCTGGTGAAGGATTTGGCAAAACCG
CCGCTATTATACAGCTCGCTCCTAAAGCTCCTGTTGACCTGTGTGAGACAGAGAAACTGAGGGCAGCCTTCTTTGCAGTCCCGTTGGAAA
TGAGAGGGTCCTTCCTGGTGCTGCTCCTGAGGGAATGCTTCCGAGACCTGAGCTGGCTGGCACTCATCCATAGCGTCCGTGGGGAGGCGG
GGCTGCTGGTGACGAGTATCGTCCCGAAGACCCCGTTTTTCTGGGCTATGCACGTCACTGAGGCTCTGCACCAGAACATGCAGGCTCTGT
TTAGCACCCTGGCTCAGGCGGAGGAGCAGCAGCCCTACCTGGAGGGCTCCACCGTTATGCGCGGGACTCGCTGTCTGGCAGAGTACCACC
TGGGGGATTATGGACACGCCTGGAACAGGTGTTGGGTGCTGGACAGGGTGGACACCTGGGCTGTGGTCATGTTCATTGATTTTGGACAGT
TGGCCACCATCCCTGTGCAGTCTCTGCGCAGCCTAGACAGCGACGACTTCTGGACCATCCCACCCCTGACTCAGCCATTCATGCTGGAGA
AAGACATTTTGAGTTCGTATGAGGTTGTCCATCGAATCCTCAAAGGGAAAATCACTGGTGCTTTGAACTCGGCGGTAACTGCTCCTGCAT
CTAACTTGGCTGTTGTCCCTCCACTCCTGCCCTTGGGGTGTCTGCAGCAGGCTGCTGCCTAGGCCTGGACACAGTATTTACCTGGCATTC
TTTTAGATCAAACGAACTGGTTATCTGAGGGGTTGGGTGAACTGGCTCGGGTGGGCCTTCCTTCCCACCAAGGCTTTGTCTTTCTCTTCC
AGTTGCACATCCTAAAGTTTGAAGAGTCTAAATAACGGGGCTTCCCTCAGCATGTTCCCTCTCCTGTTTGCCACGGATCCAGAGGCCACC
TGCCCTGTCTTCTCGTACCCCTTTCACTCTTGAGGCCTGGGAGGTGAAAAAGGCCAGACTGTGCCCAGGATTGATTCAATTTTGCTTTTA
CTCCCAGCTTCCCTCTCAAAAGAGAGTGAAGTCTCATTTGTCATGTGTCTTCAGTTCCCCAACTTGGCATGAACATTTGAACCAAACATA
GGAAACTACCATTAGGTTGAAAGCCTGAGGCAGCTGGGATGGTCTTTCTTGTGTCTCTTCTTTGCACCCCAGAGCATGATATAAGTGGTC
CTAACAGATTCTGGATAATGGAGAAGCCCTCTGCTGGTTTTCCTGGCATTCCATGTAGAATAGGTAGAGAATATTTAACCAATGAGCAAA
TAAATGTTGGCATGTTTCATGA

>11481_11481_3_C20orf194-TDRD10_C20orf194_chr20_3354695_ENST00000252032_TDRD10_chr1_154514500_ENST00000368480_length(amino acids)=447AA_BP=204
MDVYPPRRQGLPRARSPGGSSRGSPSVSCSRLRQVQSILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLFGLYNQNTSDFEKTGFSE
EVLDDVIILIKSDSVHLYCNPVNFRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKITSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVE
KWPIVQAFALEGIGGDGFFTMKYEVLEKASGEGFGKTAAIIQLAPKAPVDLCETEKLRAAFFAVPLEMRGSFLVLLLRECFRDLSWLALI
HSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAEYHLGDYGHAWNRCWVLDRVDTWAVV
MFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKITGALNSAVTAPASNLAVVPPLLPLGCLQQAAA

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>11481_11481_4_C20orf194-TDRD10_C20orf194_chr20_3354695_ENST00000252032_TDRD10_chr1_154514500_ENST00000368482_length(transcript)=1804nt_BP=680nt
GCCGCCCTGCGGGCAACTGAGACCCTCGCAGCTGCACCGTCCTCCTCCGCCGCCAGTCGTCCGCCGCCATGGACGTGTACCCCCCGCGCC
GGCAGGGGCTGCCCCGCGCTCGGTCCCCTGGCGGCTCCAGCCGCGGGTCACCCTCCGTCAGCTGCAGTCGACTTCGGCAGGTTCAGAGCA
TCCTGACCCAGAGCAGCAAGTCTCGGCCGGATGGGATCCTCTGCATCCTAGGAATCGATAGCAGGTACAATGAAGGCTGCAGAGAGCTGG
CAAATTATCTTCTATTTGGTTTGTACAATCAGAATACCAGTGATTTTGAGAAAACGGGATTTTCTGAAGAAGTACTAGATGATGTAATTA
TATTGATTAAATCGGATAGCGTCCATCTGTACTGTAATCCTGTAAACTTTCGCTATCTCTTACCTTATGTGGCACATTGGAGAAATCTGC
ATTTCCACTGCATGACCGAAAATGAGTATGAAGATGAAGAAGCCGCAGAAGAATTTAAAATTACCAGCTTTGTGGACATGGTTCGAGACT
GTAGTAGAATTGGCATTCCTTACAGCTCCCAAGGTCACTTGCAGATATTTGATATGTTTGTGGTGGAGAAATGGCCAATTGTACAGGCCT
TTGCACTTGAGGGCATTGGAGGGGATGGATTTTTTACCATGAAATATGAGGTGTTGGAGAAGGCTTCTGGTGAAGGATTTGGCAAAACCG
CCGCTATTATACAGCTCGCTCCTAAAGCTCCTGTTGACCTGTGTGAGACAGAGAAACTGAGGGCAGCCTTCTTTGCAGTCCCGTTGGAAA
TGAGAGGGTCCTTCCTGGTGCTGCTCCTGAGGGAATGCTTCCGAGACCTGAGCTGGCTGGCACTCATCCATAGCGTCCGTGGGGAGGCGG
GGCTGCTGGTGACGAGTATCGTCCCGAAGACCCCGTTTTTCTGGGCTATGCACGTCACTGAGGCTCTGCACCAGAACATGCAGGCTCTGT
TTAGCACCCTGGCTCAGGCGGAGGAGCAGCAGCCCTACCTGGAGGGCTCCACCGTTATGCGCGGGACTCGCTGTCTGGCAGAGTACCACC
TGGGGGATTATGGACACGCCTGGAACAGGTGTTGGGTGCTGGACAGGGTGGACACCTGGGCTGTGGTCATGTTCATTGATTTTGGACAGT
TGGCCACCATCCCTGTGCAGTCTCTGCGCAGCCTAGACAGCGACGACTTCTGGACCATCCCACCCCTGACTCAGCCATTCATGCTGGAGA
AAGACATTTTGAGTTCGTATGAGGTTGTCCATCGAATCCTCAAAGGGAAAATCACTGGTGCTTTGAACTCGGCGTTGCACATCCTAAAGT
TTGAAGAGTCTAAATAACGGGGCTTCCCTCAGCATGTTCCCTCTCCTGTTTGCCACGGATCCAGAGGCCACCTGCCCTGTCTTCTCGTAC
CCCTTTCACTCTTGAGGCCTGGGAGGTGAAAAAGGCCAGACTGTGCCCAGGATTGATTCAATTTTGCTTTTACTCCCAGCTTCCCTCTCA
AAAGAGAGTGAAGTCTCATTTGTCATGTGTCTTCAGTTCCCCAACTTGGCATGAACATTTGAACCAAACATAGGAAACTACCATTAGGTT
GAAAGCCTGAGGCAGCTGGGATGGTCTTTCTTGTGTCTCTTCTTTGCACCCCAGAGCATGATATAAGTGGTCCTAACAGATTCTGGATAA
TGGAGAAGCCCTCTGCTGGTTTTCCTGGCATTCCATGTAGAATAGGTAGAGAATATTTAACCAATGAGCAAATAAATGTTGGCATGTTTC
ATGA

>11481_11481_4_C20orf194-TDRD10_C20orf194_chr20_3354695_ENST00000252032_TDRD10_chr1_154514500_ENST00000368482_length(amino acids)=432AA_BP=204
MDVYPPRRQGLPRARSPGGSSRGSPSVSCSRLRQVQSILTQSSKSRPDGILCILGIDSRYNEGCRELANYLLFGLYNQNTSDFEKTGFSE
EVLDDVIILIKSDSVHLYCNPVNFRYLLPYVAHWRNLHFHCMTENEYEDEEAAEEFKITSFVDMVRDCSRIGIPYSSQGHLQIFDMFVVE
KWPIVQAFALEGIGGDGFFTMKYEVLEKASGEGFGKTAAIIQLAPKAPVDLCETEKLRAAFFAVPLEMRGSFLVLLLRECFRDLSWLALI
HSVRGEAGLLVTSIVPKTPFFWAMHVTEALHQNMQALFSTLAQAEEQQPYLEGSTVMRGTRCLAEYHLGDYGHAWNRCWVLDRVDTWAVV
MFIDFGQLATIPVQSLRSLDSDDFWTIPPLTQPFMLEKDILSSYEVVHRILKGKITGALNSALHILKFEESK

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Fusion Gene PPI Analysis for C20orf194-TDRD10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for C20orf194-TDRD10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for C20orf194-TDRD10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource