Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ACOT11-C8B (FusionGDB2 ID:HG26027TG732)

Fusion Gene Summary for ACOT11-C8B

check button Fusion gene summary
Fusion gene informationFusion gene name: ACOT11-C8B
Fusion gene ID: hg26027tg732
HgeneTgene
Gene symbol

ACOT11

C8B

Gene ID

26027

732

Gene nameacyl-CoA thioesterase 11complement C8 beta chain
SynonymsBFIT|STARD14|THEA|THEM1C82
Cytomap('ACOT11')('C8B')

1p32.3

1p32.2

Type of geneprotein-codingprotein-coding
Descriptionacyl-coenzyme A thioesterase 11START domain containing 14StAR-related lipid transfer (START) domain containing 14acyl-CoA thioester hydrolase 11adipose-associated thioesterasebrown fat-inducible thioesterasepalmitoyl-coenzyme A thioesterasethioestecomplement component C8 beta chaincomplement component 8 subunit betacomplement component 8, beta polypeptide
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000343744, ENST00000371316, 
ENST00000481208, 
Fusion gene scores* DoF score4 X 3 X 3=361 X 1 X 1=1
# samples 41
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(1/1*10)=3.32192809488736
Context

PubMed: ACOT11 [Title/Abstract] AND C8B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointACOT11(55051577)-C8B(57417853), # samples:4
Anticipated loss of major functional domain due to fusion event.ACOT11-C8B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT11-C8B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT11-C8B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ACOT11-C8B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ACOT11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across C8B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A1R7-01AACOT11chr1

55051577

-C8Bchr1

57417853

-
ChimerDB4BRCATCGA-E9-A1R7-01AACOT11chr1

55051577

+C8Bchr1

57417853

-
ChimerDB4BRCATCGA-E9-A1R7ACOT11chr1

55051577

+C8Bchr1

57417853

-


Top

Fusion Gene ORF analysis for ACOT11-C8B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000343744ENST00000494324ACOT11chr1

55051577

+C8Bchr1

57417853

-
5CDS-intronENST00000371316ENST00000494324ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000343744ENST00000371237ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000343744ENST00000535057ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000343744ENST00000543257ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000371316ENST00000371237ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000371316ENST00000535057ACOT11chr1

55051577

+C8Bchr1

57417853

-
In-frameENST00000371316ENST00000543257ACOT11chr1

55051577

+C8Bchr1

57417853

-
intron-3CDSENST00000481208ENST00000371237ACOT11chr1

55051577

+C8Bchr1

57417853

-
intron-3CDSENST00000481208ENST00000535057ACOT11chr1

55051577

+C8Bchr1

57417853

-
intron-3CDSENST00000481208ENST00000543257ACOT11chr1

55051577

+C8Bchr1

57417853

-
intron-intronENST00000481208ENST00000494324ACOT11chr1

55051577

+C8Bchr1

57417853

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343744ACOT11chr155051577+ENST00000371237C8Bchr157417853-1830393461635529
ENST00000343744ACOT11chr155051577+ENST00000543257C8Bchr157417853-1828393461635529
ENST00000343744ACOT11chr155051577+ENST00000535057C8Bchr157417853-1687393461635529
ENST00000371316ACOT11chr155051577+ENST00000371237C8Bchr157417853-1830393461635529
ENST00000371316ACOT11chr155051577+ENST00000543257C8Bchr157417853-1828393461635529
ENST00000371316ACOT11chr155051577+ENST00000535057C8Bchr157417853-1687393461635529

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343744ENST00000371237ACOT11chr155051577+C8Bchr157417853-0.0043225270.99567753
ENST00000343744ENST00000543257ACOT11chr155051577+C8Bchr157417853-0.0044632140.9955368
ENST00000343744ENST00000535057ACOT11chr155051577+C8Bchr157417853-0.0048952230.9951048
ENST00000371316ENST00000371237ACOT11chr155051577+C8Bchr157417853-0.0043225270.99567753
ENST00000371316ENST00000543257ACOT11chr155051577+C8Bchr157417853-0.0044632140.9955368
ENST00000371316ENST00000535057ACOT11chr155051577+C8Bchr157417853-0.0048952230.9951048

Top

Fusion Genomic Features for ACOT11-C8B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

Top

Fusion Protein Features for ACOT11-C8B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:55051577/chr1:57417853)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+31691_93103595.0RegionCoenzyme A binding
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+31791_93103608.0RegionCoenzyme A binding
TgeneC8Bchr1:55051577chr1:57417853ENST00000371237312505_535177592.0DomainNote=EGF-like
TgeneC8Bchr1:55051577chr1:57417853ENST00000371237312545_591177592.0DomainTSP type-1 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+316216_329103595.0DomainHotDog ACOT-type 2
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+316375_585103595.0DomainSTART
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+31643_155103595.0DomainHotDog ACOT-type 1
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+317216_329103608.0DomainHotDog ACOT-type 2
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+317375_585103608.0DomainSTART
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+31743_155103608.0DomainHotDog ACOT-type 1
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+316120_122103595.0RegionCoenzyme A binding
HgeneACOT11chr1:55051577chr1:57417853ENST00000343744+316271_273103595.0RegionCoenzyme A binding
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+317120_122103608.0RegionCoenzyme A binding
HgeneACOT11chr1:55051577chr1:57417853ENST00000371316+317271_273103608.0RegionCoenzyme A binding
TgeneC8Bchr1:55051577chr1:57417853ENST00000371237312120_157177592.0DomainLDL-receptor class A
TgeneC8Bchr1:55051577chr1:57417853ENST00000371237312158_504177592.0DomainMACPF
TgeneC8Bchr1:55051577chr1:57417853ENST0000037123731264_117177592.0DomainTSP type-1 1


Top

Fusion Gene Sequence for ACOT11-C8B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>1360_1360_1_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000371237_length(transcript)=1830nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGAACTCATGCCAGCTCAGCCCTACA
CCAGTTTCCACCTGGAGTTCATGCAAGGGCAAAAGGCAGTGCCATGCAAGCTGTTTAAAATAAAGATGTTACCTTGTAAAATGCAAGTTG
ATTTAAATAAATACTGAGTTAAAGGCTTAA

>1360_1360_1_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000371237_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------
>1360_1360_2_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000535057_length(transcript)=1687nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGA

>1360_1360_2_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000535057_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------
>1360_1360_3_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000543257_length(transcript)=1828nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGAACTCATGCCAGCTCAGCCCTACA
CCAGTTTCCACCTGGAGTTCATGCAAGGGCAAAAGGCAGTGCCATGCAAGCTGTTTAAAATAAAGATGTTACCTTGTAAAATGCAAGTTG
ATTTAAATAAATACTGAGTTAAAGGCTT

>1360_1360_3_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000343744_C8B_chr1_57417853_ENST00000543257_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------
>1360_1360_4_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000371237_length(transcript)=1830nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGAACTCATGCCAGCTCAGCCCTACA
CCAGTTTCCACCTGGAGTTCATGCAAGGGCAAAAGGCAGTGCCATGCAAGCTGTTTAAAATAAAGATGTTACCTTGTAAAATGCAAGTTG
ATTTAAATAAATACTGAGTTAAAGGCTTAA

>1360_1360_4_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000371237_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------
>1360_1360_5_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000535057_length(transcript)=1687nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGA

>1360_1360_5_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000535057_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------
>1360_1360_6_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000543257_length(transcript)=1828nt_BP=393nt
ATTTGGAGTCAGGCCTGGCTGTTGCTCAGGTGACCAGCTTGTGTCTCTGGGAGGGCGCTGCTTTCCCCGGCCACCCGGCGCGATGATCCA
GAATGTCGGAAATCACCTGCGACGGGGCTTGGCCTCTGTGTTCTCCAACCGCACATCCCGGAAGTCAGCCTTACGTGCGGGGAACGACAG
TGCCATGGCAGACGGCGAGGGATACCGGAACCCCACGGAGGTGCAGATGAGCCAGCTGGTGCTGCCCTGCCACACCAACCAACGTGGTGA
GCTGAGCGTCGGGCAGCTGCTCAAGTGGATTGACACCACGGCTTGCCTGTCCGCGGAGAGGCACGCTGGCTGCCCCTGTGTCACAGCTTC
CATGGATGACATCTATTTTGAGCACACCATTAGGATAAATTTGTTCACAAACAGTTTTGAGGGCCCAGTTCTTGATCACAGGTATTATGC
AGGTGGATGCTCCCCGCATTACATCCTGAACACGAGGTTTAGGAAGCCCTACAATGTGGAAAGCTACACGCCACAGACCCAAGGCAAATA
CGAATTCATATTAAAAGAGTATGAATCATACTCAGATTTTGAACGCAATGTCACAGAGAAAATGGCAAGCAAGTCTGGTTTCAGTTTTGG
TTTTAAAATACCTGGAATATTTGAACTTGGCATCAGTAGTCAAAGTGATCGAGGCAAACACTATATTAGGAGAACCAAACGATTCTCTCA
TACTAAAAGCGTATTTCTGCATGCACGCTCTGACCTTGAAGTAGCACATTACAAGCTGAAACCCAGAAGCCTCATGCTCCATTACGAGTT
CCTTCAGAGAGTTAAGCGGCTGCCCCTGGAGTACAGCTACGGGGAATACAGAGATCTCTTCCGTGATTTTGGGACCCACTACATCACAGA
GGCTGTGCTTGGGGGCATTTATGAATACACCCTCGTTATGAACAAAGAGGCCATGGAGAGAGGAGATTATACTCTTAACAACGTCCATGC
CTGTGCCAAAAATGATTTTAAAATTGGTGGTGCCATTGAAGAGGTCTACGTCAGTCTGGGTGTGTCTGTAGGCAAATGCAGAGGTATTCT
GAATGAAATAAAAGACAGAAACAAGAGGGACACCATGGTGGAGGACTTGGTGGTCCTGGTACGAGGAGGGGCAAGTGAGCACATCACCAC
CCTGGCATACCAGGAGCTGCCGACGGCGGACCTGATGCAGGAGTGGGGAGACGCTGTGCAGTACAACCCAGCCATCATCAAAGTTAAGGT
GGAGCCTCTGTATGAACTAGTGACAGCCACAGATTTTGCCTATTCCAGCACAGTGAGGCAGAACATGAAGCAGGCACTGGAGGAGTTCCA
GAAGGAAGTTAGTTCCTGCCACTGTGCTCCCTGCCAAGGAAATGGAGTCCCTGTCCTGAAAGGATCACGCTGTGACTGCATCTGTCCTGT
TGGATCCCAAGGCCTAGCCTGTGAGGTCTCCTATCGGAAGAATACCCCCATTGATGGGAAGTGGAATTGCTGGTCAAATTGGTCTTCATG
CTCTGGAAGACGTAAGACAAGACAAAGGCAGTGTAACAATCCACCTCCTCAAAATGGGGGTAGCCCCTGTTCAGGCCCTGCTTCAGAAAC
ACTTGACTGCTCCTAGCAGATGATACAGCAGTGGGCTACATACAATGAGAGCCCTGAGCCCTCAAGAACTCATGCCAGCTCAGCCCTACA
CCAGTTTCCACCTGGAGTTCATGCAAGGGCAAAAGGCAGTGCCATGCAAGCTGTTTAAAATAAAGATGTTACCTTGTAAAATGCAAGTTG
ATTTAAATAAATACTGAGTTAAAGGCTT

>1360_1360_6_ACOT11-C8B_ACOT11_chr1_55051577_ENST00000371316_C8B_chr1_57417853_ENST00000543257_length(amino acids)=529AA_BP=115
MGGRCFPRPPGAMIQNVGNHLRRGLASVFSNRTSRKSALRAGNDSAMADGEGYRNPTEVQMSQLVLPCHTNQRGELSVGQLLKWIDTTAC
LSAERHAGCPCVTASMDDIYFEHTIRINLFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDFER
NVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGE
YRDLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMVED
LVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNG
VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ACOT11-C8B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ACOT11-C8B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ACOT11-C8B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0003257Antibody Deficiency Syndrome1CTD_human
TgeneC0021051Immunologic Deficiency Syndromes1CTD_human
TgeneC0025289Meningitis1CTD_human
TgeneC0030167Pachymeningitis1CTD_human
TgeneC0085396Neisseriaceae Infections1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0272242Complement deficiency disease1GENOMICS_ENGLAND
TgeneC3151080COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE II1CTD_human;GENOMICS_ENGLAND
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human