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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:ANKRD17-PAK1 (FusionGDB2 ID:HG26057TG5058)

Fusion Gene Summary for ANKRD17-PAK1

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD17-PAK1
Fusion gene ID: hg26057tg5058
HgeneTgene
Gene symbol

ANKRD17

PAK1

Gene ID

26057

5058

Gene nameankyrin repeat domain 17p21 (RAC1) activated kinase 1
SynonymsGTAR|MASK2|NY-BR-16IDDMSSD|PAKalpha|alpha-PAK|p65-PAK
Cytomap('ANKRD17')('PAK1')

4q13.3

11q13.5-q14.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16serine/threonine-protein kinase PAK 1STE20 homolog, yeastp21 protein (Cdc42/Rac)-activated kinase 1p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000330838, ENST00000358602, 
ENST00000509867, ENST00000514252, 
Fusion gene scores* DoF score14 X 22 X 6=184822 X 17 X 10=3740
# samples 2526
** MAII scorelog2(25/1848*10)=-2.88596475675397
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(26/3740*10)=-3.84645474174655
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD17 [Title/Abstract] AND PAK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD17(74123992)-PAK1(77070062), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD17-PAK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD17-PAK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD17-PAK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD17-PAK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD17

GO:0042742

defense response to bacterium

23711367

HgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

HgeneANKRD17

GO:0045087

innate immune response

23711367

HgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

HgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336

TgenePAK1

GO:0000165

MAPK cascade

8805275

TgenePAK1

GO:0006338

chromatin remodeling

23260667

TgenePAK1

GO:0006468

protein phosphorylation

9852149|23260667

TgenePAK1

GO:0006974

cellular response to DNA damage stimulus

23260667

TgenePAK1

GO:0030335

positive regulation of cell migration

25766321

TgenePAK1

GO:0031532

actin cytoskeleton reorganization

9395435

TgenePAK1

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgenePAK1

GO:0033148

positive regulation of intracellular estrogen receptor signaling pathway

16278681

TgenePAK1

GO:0046777

protein autophosphorylation

8805275


check buttonFusion gene breakpoints across ANKRD17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PAK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-D1-A17CANKRD17chr4

74123992

-PAK1chr11

77070062

-


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Fusion Gene ORF analysis for ANKRD17-PAK1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000330838ENST00000525542ANKRD17chr4

74123992

-PAK1chr11

77070062

-
5CDS-intronENST00000358602ENST00000525542ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000330838ENST00000278568ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000330838ENST00000356341ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000330838ENST00000528203ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000330838ENST00000530617ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000358602ENST00000278568ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000358602ENST00000356341ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000358602ENST00000528203ANKRD17chr4

74123992

-PAK1chr11

77070062

-
In-frameENST00000358602ENST00000530617ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000509867ENST00000278568ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000509867ENST00000356341ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000509867ENST00000528203ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000509867ENST00000530617ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000514252ENST00000278568ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000514252ENST00000356341ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000514252ENST00000528203ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-3CDSENST00000514252ENST00000530617ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-intronENST00000509867ENST00000525542ANKRD17chr4

74123992

-PAK1chr11

77070062

-
intron-intronENST00000514252ENST00000525542ANKRD17chr4

74123992

-PAK1chr11

77070062

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000358602ANKRD17chr474123992-ENST00000356341PAK1chr1177070062-32385101111670519
ENST00000358602ANKRD17chr474123992-ENST00000530617PAK1chr1177070062-27225101111601496
ENST00000358602ANKRD17chr474123992-ENST00000278568PAK1chr1177070062-20465101111694527
ENST00000358602ANKRD17chr474123992-ENST00000528203PAK1chr1177070062-19705101111694527
ENST00000330838ANKRD17chr474123992-ENST00000356341PAK1chr1177070062-32515231241683519
ENST00000330838ANKRD17chr474123992-ENST00000530617PAK1chr1177070062-27355231241614496
ENST00000330838ANKRD17chr474123992-ENST00000278568PAK1chr1177070062-20595231241707527
ENST00000330838ANKRD17chr474123992-ENST00000528203PAK1chr1177070062-19835231241707527

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000358602ENST00000356341ANKRD17chr474123992-PAK1chr1177070062-0.0013619830.998638
ENST00000358602ENST00000530617ANKRD17chr474123992-PAK1chr1177070062-0.0014979080.99850214
ENST00000358602ENST00000278568ANKRD17chr474123992-PAK1chr1177070062-0.0046431920.99535674
ENST00000358602ENST00000528203ANKRD17chr474123992-PAK1chr1177070062-0.0052919690.99470806
ENST00000330838ENST00000356341ANKRD17chr474123992-PAK1chr1177070062-0.0013809830.99861896
ENST00000330838ENST00000530617ANKRD17chr474123992-PAK1chr1177070062-0.0014935350.9985065
ENST00000330838ENST00000278568ANKRD17chr474123992-PAK1chr1177070062-0.0047339260.9952661
ENST00000330838ENST00000528203ANKRD17chr474123992-PAK1chr1177070062-0.0053957980.9946042

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Fusion Genomic Features for ANKRD17-PAK1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANKRD17-PAK1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:74123992/chr11:77070062)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-13396_1101312353.0Compositional biasNote=Gly-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-13496_1101312604.0Compositional biasNote=Gly-rich
TgenePAK1chr4:74123992chr11:77070062ENST00000278568416270_521159554.0DomainProtein kinase
TgenePAK1chr4:74123992chr11:77070062ENST00000356341415270_521159546.0DomainProtein kinase
TgenePAK1chr4:74123992chr11:77070062ENST00000278568416276_284159554.0Nucleotide bindingNote=ATP
TgenePAK1chr4:74123992chr11:77070062ENST00000278568416345_347159554.0Nucleotide bindingNote=ATP
TgenePAK1chr4:74123992chr11:77070062ENST00000356341415276_284159546.0Nucleotide bindingNote=ATP
TgenePAK1chr4:74123992chr11:77070062ENST00000356341415345_347159546.0Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331442_15261312353.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341442_15261312604.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331603_17001312353.0Compositional biasNote=Ser-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331950_21061312353.0Compositional biasNote=Ser-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331966_20331312353.0Compositional biasNote=Thr-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133858_10081312353.0Compositional biasNote=Gln-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341603_17001312604.0Compositional biasNote=Ser-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341950_21061312604.0Compositional biasNote=Ser-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341966_20331312604.0Compositional biasNote=Thr-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134858_10081312604.0Compositional biasNote=Gln-rich
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331725_17891312353.0DomainKH
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341725_17891312604.0DomainKH
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331082_11111312353.0RepeatNote=ANK 16
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331115_11441312353.0RepeatNote=ANK 17
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331149_11781312353.0RepeatNote=ANK 18
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331182_12111312353.0RepeatNote=ANK 19
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331217_12461312353.0RepeatNote=ANK 20
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331251_12801312353.0RepeatNote=ANK 21
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331284_13131312353.0RepeatNote=ANK 22
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331319_13481312353.0RepeatNote=ANK 23
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331352_13811312353.0RepeatNote=ANK 24
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-1331385_14141312353.0RepeatNote=ANK 25
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133233_2621312353.0RepeatNote=ANK 1
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133266_2951312353.0RepeatNote=ANK 2
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133300_3291312353.0RepeatNote=ANK 3
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133333_3621312353.0RepeatNote=ANK 4
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133366_3951312353.0RepeatNote=ANK 5
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133400_4291312353.0RepeatNote=ANK 6
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133433_4621312353.0RepeatNote=ANK 7
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133466_4951312353.0RepeatNote=ANK 8
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133499_5281312353.0RepeatNote=ANK 9
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133533_5621312353.0RepeatNote=ANK 10
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133563_5921312353.0RepeatNote=ANK 11
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133596_6251312353.0RepeatNote=ANK 12
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133629_6581312353.0RepeatNote=ANK 13
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133663_6921312353.0RepeatNote=ANK 14
HgeneANKRD17chr4:74123992chr11:77070062ENST00000330838-133696_7251312353.0RepeatNote=ANK 15
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341082_11111312604.0RepeatNote=ANK 16
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341115_11441312604.0RepeatNote=ANK 17
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341149_11781312604.0RepeatNote=ANK 18
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341182_12111312604.0RepeatNote=ANK 19
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341217_12461312604.0RepeatNote=ANK 20
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341251_12801312604.0RepeatNote=ANK 21
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341284_13131312604.0RepeatNote=ANK 22
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341319_13481312604.0RepeatNote=ANK 23
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341352_13811312604.0RepeatNote=ANK 24
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-1341385_14141312604.0RepeatNote=ANK 25
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134233_2621312604.0RepeatNote=ANK 1
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134266_2951312604.0RepeatNote=ANK 2
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134300_3291312604.0RepeatNote=ANK 3
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134333_3621312604.0RepeatNote=ANK 4
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134366_3951312604.0RepeatNote=ANK 5
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134400_4291312604.0RepeatNote=ANK 6
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134433_4621312604.0RepeatNote=ANK 7
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134466_4951312604.0RepeatNote=ANK 8
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134499_5281312604.0RepeatNote=ANK 9
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134533_5621312604.0RepeatNote=ANK 10
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134563_5921312604.0RepeatNote=ANK 11
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134596_6251312604.0RepeatNote=ANK 12
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134629_6581312604.0RepeatNote=ANK 13
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134663_6921312604.0RepeatNote=ANK 14
HgeneANKRD17chr4:74123992chr11:77070062ENST00000358602-134696_7251312604.0RepeatNote=ANK 15
TgenePAK1chr4:74123992chr11:77070062ENST0000027856841675_88159554.0DomainCRIB
TgenePAK1chr4:74123992chr11:77070062ENST0000035634141575_88159546.0DomainCRIB
TgenePAK1chr4:74123992chr11:77070062ENST0000027856841670_140159554.0RegionNote=Autoregulatory region
TgenePAK1chr4:74123992chr11:77070062ENST0000027856841675_105159554.0RegionNote=GTPase-binding
TgenePAK1chr4:74123992chr11:77070062ENST0000035634141570_140159546.0RegionNote=Autoregulatory region
TgenePAK1chr4:74123992chr11:77070062ENST0000035634141575_105159546.0RegionNote=GTPase-binding


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Fusion Gene Sequence for ANKRD17-PAK1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4606_4606_1_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000278568_length(transcript)=2059nt_BP=523nt
AGTAGAGGTGACCGAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCC
ACGCCCCTCCCCCGTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGA
AGGGAGCCCCCCGGCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTC
GGCCTCGTCTCCTCGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAA
CCGGACTTGCCGACCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGG
CGGCGGCGGCACCAGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTC
TGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGA
GCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTAC
TGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGA
GAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTA
CACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGA
GATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGA
ATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCA
GGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCT
AACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGT
TGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCT
CAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCG
GGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGGTGAGAAAACTGAGGTTTCAAGT
GTTTAGTAACTTTTCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGG
AGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCC
AACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCC
AGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTG
GTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCT

>4606_4606_1_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000278568_length(amino acids)=527AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>4606_4606_2_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000356341_length(transcript)=3251nt_BP=523nt
AGTAGAGGTGACCGAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCC
ACGCCCCTCCCCCGTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGA
AGGGAGCCCCCCGGCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTC
GGCCTCGTCTCCTCGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAA
CCGGACTTGCCGACCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGG
CGGCGGCGGCACCAGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTC
TGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGA
GCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTAC
TGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGA
GAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTA
CACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGA
GATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGA
ATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCA
GGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCT
AACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGT
TGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCT
CAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCG
GGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCATCAATTCCTGAAGATTGCCAA
GCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGT
GCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATC
TAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTT
CTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTG
TCAAAATCCTCACCTCCTTCATAACCATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGATAATATTATCAATTTGTAATC
AATTGAGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCA
TGGGGTTTGATAATCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACC
ACATTTTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGG
CTATGTAGCAGCTTTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCAC
ATACTGAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTT
GTGTGATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTG
GTCACAATAAAGAGTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGG
ACCCCGTTTTTAAGATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTT
GTGGTTTTGGTTCTCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAG
GTACTACTGCCTCTGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATGAAAATATTCTATTGGAGTATGCCTTTCTTTTTTCTCTT
CGTTTTTTCTTTCCTTTTCTAATTTTTTATATGAAATAATGAGTAGTTTCTTCCTGAACCATTTGAGAGTGGTAAGTTGCAGATAGAATG
CCCCTTTACCACTATATACCTGAATGTGTATTCTTTCTTTTTAACACTTTTATTTTAAATATAAATTAAGAGAAATGGGCCAAAACCATT
TGTATTGTTTAAAGAATAATTATAAACACACTTGTATCCACCAAATCAAGAAATGGAACACTGACAGTAAGAACCTTCTCTATCTTGTCC
TTCCTTTCTCA

>4606_4606_2_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000356341_length(amino acids)=519AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

--------------------------------------------------------------
>4606_4606_3_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000528203_length(transcript)=1983nt_BP=523nt
AGTAGAGGTGACCGAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCC
ACGCCCCTCCCCCGTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGA
AGGGAGCCCCCCGGCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTC
GGCCTCGTCTCCTCGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAA
CCGGACTTGCCGACCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGG
CGGCGGCGGCACCAGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTC
TGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGA
GCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTAC
TGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGA
GAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTA
CACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGA
GATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGA
ATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCA
GGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCT
AACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGT
TGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCT
CAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCG
GGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGGTGAGAAAACTGAGGTTTCAAGT
GTTTAGTAACTTTTCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGG
AGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCC
AACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCC
AGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTG
GTT

>4606_4606_3_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000528203_length(amino acids)=527AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>4606_4606_4_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000530617_length(transcript)=2735nt_BP=523nt
AGTAGAGGTGACCGAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCC
ACGCCCCTCCCCCGTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGA
AGGGAGCCCCCCGGCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTC
GGCCTCGTCTCCTCGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAA
CCGGACTTGCCGACCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGG
CGGCGGCGGCACCAGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTC
TGAGACTCCTGCAGTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGA
GCACACAAAATCTGTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTAC
TGAAAATAACACCACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGA
GAAATTACGAAGCATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTA
CACAGCAATGGATGTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGA
GATCCTGGTCATGAGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGA
ATACTTGGCTGGAGGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCA
GGCTCTGGAGTTCTTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCT
AACTGACTTTGGATTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGT
TGTGACACGAAAGGCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCT
CAATGAAAACCCTCTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCG
GGACTTTCTGAACCGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCACTCCTCAAGACTTTGATCCTT
GGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTC
ATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACC
ATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGATAATATTATCAATTTGTAATCAATTGAGATTTCTTTAGTGCTTGCTT
TTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCATGGGGTTTGATAATCTGCCAGGGACA
TGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACCACATTTTTCTTTGTGTGTGCTTCTAG
CAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGGCTATGTAGCAGCTTTTGATTCCCTGC
ATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCACATACTGAGTGAGAGCAGTGTTGAGAA
GTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTTGTGTGATGTTTCAGGAACTCAGCCCC
TTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTGGTCACAATAAAGAGTCTCCAAATTAG
AGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGGACCCCGTTTTTAAGATGCATGGCCAA
GCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTTGTGGTTTTGGTTCTCCCACTATGGTA
GGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAGGTACTACTGCCTCTGCAGCACAAATT
TCTATTTCTGTCAATAAAAGGAGATGAAAATATTC

>4606_4606_4_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000330838_PAK1_chr11_77070062_ENST00000530617_length(amino acids)=496AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHSSRL

--------------------------------------------------------------
>4606_4606_5_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000278568_length(transcript)=2046nt_BP=510nt
GAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCCACGCCCCTCCCCC
GTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGAAGGGAGCCCCCCG
GCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTCGGCCTCGTCTCCT
CGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAACCGGACTTGCCGA
CCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGGCGGCGGCGGCACC
AGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTCTGAGACTCCTGCA
GTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCT
GTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACC
ACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGC
ATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGAT
GTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATG
AGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGA
GGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTC
TTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGA
TTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAG
GCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCT
CTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAAC
CGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGGTGAGAAAACTGAGGTTTCAAGTGTTTAGTAACTTT
TCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAA
CAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCC
CTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGA
ACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAG
GGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCT

>4606_4606_5_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000278568_length(amino acids)=527AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>4606_4606_6_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000356341_length(transcript)=3238nt_BP=510nt
GAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCCACGCCCCTCCCCC
GTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGAAGGGAGCCCCCCG
GCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTCGGCCTCGTCTCCT
CGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAACCGGACTTGCCGA
CCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGGCGGCGGCGGCACC
AGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTCTGAGACTCCTGCA
GTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCT
GTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACC
ACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGC
ATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGAT
GTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATG
AGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGA
GGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTC
TTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGA
TTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAG
GCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCT
CTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAAC
CGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGC
CTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAACAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTG
TGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCCCTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAA
GACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAAT
TTCCTCCCAATTCATGGATATGAGGGTGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCAC
CTCCTTCATAACCATCTCCCACAATTAATTCTTGACTATATAAATTTATGGTTTGATAATATTATCAATTTGTAATCAATTGAGATTTCT
TTAGTGCTTGCTTTTCTGTGACTCAACTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCATGGGGTTTGATAA
TCTGCCAGGGACATGAAGAGGCTCAGCTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACCACATTTTTCTTTG
TGTGTGCTTCTAGCAGCTGTTCGGGAGGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGGCTATGTAGCAGCT
TTTGATTCCCTGCATACCCTAGGCTGCTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCACATACTGAGTGAGA
GCAGTGTTGAGAAGTCGGGGAAAATGGTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTTGTGTGATGTTTCA
GGAACTCAGCCCCTTTTTCTGCCTAGGATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTGGTCACAATAAAGA
GTCTCCAAATTAGAGACTGCATGTTAGTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGGACCCCGTTTTTAA
GATGCATGGCCAAGCTCTCTGCAAATGGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTTGTGGTTTTGGTTC
TCCCACTATGGTAGGACCCCTGGCCAGCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAGGTACTACTGCCTC
TGCAGCACAAATTTCTATTTCTGTCAATAAAAGGAGATGAAAATATTCTATTGGAGTATGCCTTTCTTTTTTCTCTTCGTTTTTTCTTTC
CTTTTCTAATTTTTTATATGAAATAATGAGTAGTTTCTTCCTGAACCATTTGAGAGTGGTAAGTTGCAGATAGAATGCCCCTTTACCACT
ATATACCTGAATGTGTATTCTTTCTTTTTAACACTTTTATTTTAAATATAAATTAAGAGAAATGGGCCAAAACCATTTGTATTGTTTAAA
GAATAATTATAAACACACTTGTATCCACCAAATCAAGAAATGGAACACTGACAGTAAGAACCTTCTCTATCTTGTCCTTCCTTTCTCA

>4606_4606_6_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000356341_length(amino acids)=519AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATKNNH

--------------------------------------------------------------
>4606_4606_7_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000528203_length(transcript)=1970nt_BP=510nt
GAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCCACGCCCCTCCCCC
GTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGAAGGGAGCCCCCCG
GCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTCGGCCTCGTCTCCT
CGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAACCGGACTTGCCGA
CCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGGCGGCGGCGGCACC
AGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTCTGAGACTCCTGCA
GTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCT
GTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACC
ACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGC
ATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGAT
GTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATG
AGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGA
GGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTC
TTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGA
TTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAG
GCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCT
CTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAAC
CGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGGTGAGAAAACTGAGGTTTCAAGTGTTTAGTAACTTT
TCCATGATAGCTGCATCAATTCCTGAAGATTGCCAAGCCCCTCTCCAGCCTCACTCCACTGATTGCTGCAGCTAAGGAGGCAACAAAGAA
CAATCACTAAAACCACACTCACCCCAGCCTCATTGTGCCAAGCCTTCTGTGAGATAAATGCACATTTCAGAAATTCCAACTCCTGATGCC
CTCTTCTCCTTGCCTTGCTTCTCCCATTTCCTGATCTAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGTCCAGCATTGAAGAGA
ACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGGTGGTT

>4606_4606_7_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000528203_length(amino acids)=527AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQVRKLRFQVFSNFSMIAASIPEDCQAPLQPHSTDCCS

--------------------------------------------------------------
>4606_4606_8_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000530617_length(transcript)=2722nt_BP=510nt
GAGGCGGTGGCGGCGGAGGCGGCACCGATTGCTGTGTCGGCCCCAGTGCGGCCGAAGTCGCGGTAGAGCGTAGCCCCACGCCCCTCCCCC
GTCCGCGCCCTCCCTCTTTCCCTGGGGATGGAGAAGGCGACGGTTCCGGTGGCGGCGGCGACGGCTGCAGAAGGAGAAGGGAGCCCCCCG
GCGGTGGCGGCTGTGGCGGGCCCCCCCGCGGCGGCGGAGGTCGGCGGCGGCGTTGGCGGCAGCAGCAGAGCTCGCTCGGCCTCGTCTCCT
CGTGGGATGGTGCGAGTCTGCGACCTGCTCCTGAAGAAGAAGCCGCCGCAGCAGCAGCACCACAAGGCCAAGCGTAACCGGACTTGCCGA
CCCCCCAGCAGCAGCGAAAGCAGCAGCGACAGCGACAACAGCGGCGGCGGTGGAGGCGGCGGTGGAGGCGGAGGTGGCGGCGGCGGCACC
AGCAGTAACAACAGCGAGGAAGAAGAGGACGACGACGACGAGGAAGAGGAGGTTTCTGAGAATGTGAAGGCTGTGTCTGAGACTCCTGCA
GTGCCACCAGTTTCAGAAGATGAGGATGATGATGATGATGATGCTACCCCACCACCAGTGATTGCTCCACGCCCAGAGCACACAAAATCT
GTATACACACGGTCTGTGATTGAACCACTTCCTGTCACTCCAACTCGGGACGTGGCTACATCTCCCATTTCACCTACTGAAAATAACACC
ACTCCACCAGATGCTTTGACCCGGAATACTGAGAAGCAGAAGAAGAAGCCTAAAATGTCTGATGAGGAGATCTTGGAGAAATTACGAAGC
ATAGTGAGTGTGGGCGATCCTAAGAAGAAATATACACGGTTTGAGAAGATTGGACAAGGTGCTTCAGGCACCGTGTACACAGCAATGGAT
GTGGCCACAGGACAGGAGGTGGCCATTAAGCAGATGAATCTTCAGCAGCAGCCCAAGAAAGAGCTGATTATTAATGAGATCCTGGTCATG
AGGGAAAACAAGAACCCAAACATTGTGAATTACTTGGACAGTTACCTCGTGGGAGATGAGCTGTGGGTTGTTATGGAATACTTGGCTGGA
GGCTCCTTGACAGATGTGGTGACAGAAACTTGCATGGATGAAGGCCAAATTGCAGCTGTGTGCCGTGAGTGTCTGCAGGCTCTGGAGTTC
TTGCATTCGAACCAGGTCATTCACAGAGACATCAAGAGTGACAATATTCTGTTGGGAATGGATGGCTCTGTCAAGCTAACTGACTTTGGA
TTCTGTGCACAGATAACCCCAGAGCAGAGCAAACGGAGCACCATGGTAGGAACCCCATACTGGATGGCACCAGAGGTTGTGACACGAAAG
GCCTATGGGCCCAAGGTTGACATCTGGTCCCTGGGCATCATGGCCATCGAAATGATTGAAGGGGAGCCTCCATACCTCAATGAAAACCCT
CTGAGAGCCTTGTACCTCATTGCCACCAATGGGACCCCAGAACTTCAGAACCCAGAGAAGCTGTCAGCTATCTTCCGGGACTTTCTGAAC
CGCTGTCTCGAGATGGATGTGGAGAAGAGAGGTTCAGCTAAAGAGCTGCTACAGCACTCCTCAAGACTTTGATCCTTGGAAACCGTGTGT
CCAGCATTGAAGAGAACTGCAACTGAATGACTAATCAGATGATGGCCATTTCTAAATAAGGAATTTCCTCCCAATTCATGGATATGAGGG
TGGTTTATGATTAAGGGTTTATATAAATAAATGTTTCTAGTCTTCCGTGTGTCAAAATCCTCACCTCCTTCATAACCATCTCCCACAATT
AATTCTTGACTATATAAATTTATGGTTTGATAATATTATCAATTTGTAATCAATTGAGATTTCTTTAGTGCTTGCTTTTCTGTGACTCAA
CTGCCCAGACACCTCATTGTACTTGAAAACTGGAACAGCTTGGGAATGCCATGGGGTTTGATAATCTGCCAGGGACATGAAGAGGCTCAG
CTTCCTGGACCATGACTTTGGCTCAGCTGATCCTGACATGGGAGAACAACCACATTTTTCTTTGTGTGTGCTTCTAGCAGCTGTTCGGGA
GGACCTTGACCCAATAGTGTTCCCATGCTGTTTCTTGTGAAATGCTCTCGGCTATGTAGCAGCTTTTGATTCCCTGCATACCCTAGGCTG
CTGCCCCTATCCTGTCCCTTGTTTATAACATTGAGAGGTTTTCTAGGGCACATACTGAGTGAGAGCAGTGTTGAGAAGTCGGGGAAAATG
GTGACTACTTTTAGAGCAAGGCTGGGCATCAGCACCTGTCCAGCTCTACTTGTGTGATGTTTCAGGAACTCAGCCCCTTTTTCTGCCTAG
GATAAGGAGCTGAAAGATTAACTTGGATCTTCTAATGGTCCAAATCTTTTGGTCACAATAAAGAGTCTCCAAATTAGAGACTGCATGTTA
GTTCTGGATGGATTTGGTGGCCTGACATGATACCCTGCCAGCTGTGAGGGGACCCCGTTTTTAAGATGCATGGCCAAGCTCTCTGCAAAT
GGAAATGCTTACACTGGGTGTTGGGGATGTTTGCTACCTCCTGCTATTTTTGTGGTTTTGGTTCTCCCACTATGGTAGGACCCCTGGCCA
GCATTGTGGCTTGTCATGTCAGCCCCATTGACTACCTTCTCATGCTCTGAGGTACTACTGCCTCTGCAGCACAAATTTCTATTTCTGTCA
ATAAAAGGAGATGAAAATATTC

>4606_4606_8_ANKRD17-PAK1_ANKRD17_chr4_74123992_ENST00000358602_PAK1_chr11_77070062_ENST00000530617_length(amino acids)=496AA_BP=133
MGMEKATVPVAAATAAEGEGSPPAVAAVAGPPAAAEVGGGVGGSSRARSASSPRGMVRVCDLLLKKKPPQQQHHKAKRNRTCRPPSSSES
SSDSDNSGGGGGGGGGGGGGGGTSSNNSEEEEDDDDEEEEVSENVKAVSETPAVPPVSEDEDDDDDDATPPPVIAPRPEHTKSVYTRSVI
EPLPVTPTRDVATSPISPTENNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEV
AIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVI
HRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLI
ATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHSSRL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD17-PAK1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgenePAK1chr4:74123992chr11:77070062ENST00000278568416132_270159.0554.0CRIPAK
TgenePAK1chr4:74123992chr11:77070062ENST00000356341415132_270159.0546.0CRIPAK


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD17-PAK1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD17-PAK1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4748428INTELLECTUAL DEVELOPMENTAL DISORDER WITH MACROCEPHALY, SEIZURES, AND SPEECH DELAY2GENOMICS_ENGLAND;UNIPROT
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0007134Renal Cell Carcinoma1CTD_human
TgeneC0033687Proteinuria1CTD_human
TgeneC0279702Conventional (Clear Cell) Renal Cell Carcinoma1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1266042Chromophobe Renal Cell Carcinoma1CTD_human
TgeneC1266043Sarcomatoid Renal Cell Carcinoma1CTD_human
TgeneC1266044Collecting Duct Carcinoma of the Kidney1CTD_human
TgeneC1306837Papillary Renal Cell Carcinoma1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1535926Neurodevelopmental Disorders1GENOMICS_ENGLAND
TgeneC4704874Mammary Carcinoma, Human1CTD_human