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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ABHD12-KIF16B (FusionGDB2 ID:HG26090TG55614)

Fusion Gene Summary for ABHD12-KIF16B

Fusion gene summary

Fusion gene information	Fusion gene name: ABHD12-KIF16B
	Fusion gene ID: hg26090tg55614
		Hgene	Tgene
	Gene symbol	ABHD12	KIF16B
	Gene ID	26090	55614
	Gene name	abhydrolase domain containing 12, lysophospholipase	kinesin family member 16B
	Synonyms	ABHD12A\|BEM46L2\|C20orf22\|PHARC\|dJ965G21.2\|hABHD12	C20orf23\|KISC20ORF\|SNX23
	Cytomap	('ABHD12')('KIF16B') 20p11.21	20p12.1
	Type of gene	protein-coding	protein-coding
	Description	lysophosphatidylserine lipase ABHD122-arachidonoylglycerol hydrolase2-arachidonoylglycerol hydrolase ABHD12abhydrolase domain containing 12abhydrolase domain-containing protein 12monoacylglycerol lipase ABHD12oxidized phosphatidylserine lipase ABHD1	kinesin-like protein KIF16Bkinesin motor proteinsorting nexin 23testis secretory sperm-binding protein Li 201a
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000339157, ENST00000376542, ENST00000481556,
Fusion gene scores	* DoF score	11 X 8 X 6=528	7 X 5 X 6=210
	# samples	13	8
	** MAII score	log2(13/528*10)=-2.02202630633 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ABHD12 [Title/Abstract] AND KIF16B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ABHD12(25282855)-KIF16B(16509085), # samples:1
Anticipated loss of major functional domain due to fusion event.	ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABHD12-KIF16B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ABHD12	GO:0006660	phosphatidylserine catabolic process	30643283
Hgene	ABHD12	GO:0009395	phospholipid catabolic process	30237167
Hgene	ABHD12	GO:0046464	acylglycerol catabolic process	22969151
Hgene	ABHD12	GO:0046475	glycerophospholipid catabolic process	25290914
Hgene	ABHD12	GO:0052651	monoacylglycerol catabolic process	25290914\|30237167

Fusion gene breakpoints across ABHD12 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KIF16B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-77-7142-01A	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-

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Fusion Gene ORF analysis for ABHD12-KIF16B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000339157	ENST00000355755	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
5CDS-5UTR	ENST00000339157	ENST00000378003	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
5CDS-5UTR	ENST00000339157	ENST00000408042	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
5CDS-5UTR	ENST00000376542	ENST00000355755	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
5CDS-5UTR	ENST00000376542	ENST00000378003	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
5CDS-5UTR	ENST00000376542	ENST00000408042	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
In-frame	ENST00000339157	ENST00000354981	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
In-frame	ENST00000376542	ENST00000354981	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
intron-3CDS	ENST00000481556	ENST00000354981	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
intron-5UTR	ENST00000481556	ENST00000355755	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
intron-5UTR	ENST00000481556	ENST00000378003	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-
intron-5UTR	ENST00000481556	ENST00000408042	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000376542	ABHD12	chr20	25282855	-	ENST00000354981	KIF16B	chr20	16509085	-	6493	1437	199	5343	1714
ENST00000339157	ABHD12	chr20	25282855	-	ENST00000354981	KIF16B	chr20	16509085	-	6486	1430	192	5336	1714

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000376542	ENST00000354981	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-	0.001841327	0.99815863
ENST00000339157	ENST00000354981	ABHD12	chr20	25282855	-	KIF16B	chr20	16509085	-	0.0018253	0.99817467

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Fusion Genomic Features for ABHD12-KIF16B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

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Fusion Protein Features for ABHD12-KIF16B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:25282855/chr20:16509085)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000339157

20_25

385

399.0

Compositional bias

Note=Poly-Ser

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000339157

26_29

385

399.0

Compositional bias

Note=Poly-Ala

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000376542

20_25

385

405.0

Compositional bias

Note=Poly-Ser

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000376542

26_29

385

405.0

Compositional bias

Note=Poly-Ala

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000339157

1_74

385

399.0

Topological domain

Cytoplasmic

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000376542

1_74

385

405.0

Topological domain

Cytoplasmic

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000339157

75_95

385

399.0

Transmembrane

Helical

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000376542

75_95

385

405.0

Transmembrane

Helical

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

370_425

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

595_882

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

936_1087

1318.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

370_425

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

595_882

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

936_1087

1288.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

370_425

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

595_882

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

936_1087

1393.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

597_1070

1318.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

597_1070

1288.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

597_1070

1393.0

Compositional bias

Note=Glu-rich

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

1182_1296

1318.0

Domain

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

478_529

1318.0

Domain

Note=FHA

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

1182_1296

1288.0

Domain

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

478_529

1288.0

Domain

Note=FHA

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

1182_1296

1393.0

Domain

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

478_529

1393.0

Domain

Note=FHA

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

102_109

1318.0

Nucleotide binding

ATP

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

102_109

1288.0

Nucleotide binding

ATP

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

102_109

1393.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000339157

96_398

385

399.0

Topological domain

Extracellular

Hgene

ABHD12

chr20:25282855

chr20:16509085

ENST00000376542

96_398

385

405.0

Topological domain

Extracellular

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000354981

3_358

1318.0

Domain

Kinesin motor

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000355755

3_358

1288.0

Domain

Kinesin motor

Tgene

KIF16B

chr20:25282855

chr20:16509085

ENST00000408042

3_358

1393.0

Domain

Kinesin motor

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Fusion Gene Sequence for ABHD12-KIF16B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>375_375_1_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000339157_KIF16B_chr20_16509085_ENST00000354981_length(transcript)=6486nt_BP=1430nt
ATGCTGGGCGCGCGCTCCTTGGAACTAGAGAGGAGGTGGCCGGGGCGGGGCCGGGGGAGGGGGGTAGGGCAGAGCCGGCGGGAGCCCGGC
GCTGATTGGCCGGCCTGGCTGGCGGGCCCCCGCCGCTGGTTCGTAGCCGGCGCAGCGGCCTGGGCTGGGATGTGAGGAGCGGCGGGTTCC
GGGCTCCGGGCTCTGGGTGGCGGCGGCTGTGAGCGGCGGCACTGCGGCGCAGGCCAGCGGGCGCCGTCGGCGGCTGGCCCTGTCGGCCGC
GGGATGAGGAAGCGGACCGAGCCCGTCGCCTTGGAGCATGAGCGCTGCGCCGCCGCGGGCTCGTCCTCCTCCGGCTCGGCCGCCGCGGCG
CTGGACGCCGACTGCCGCCTGAAGCAGAACCTACGCCTGACGGGCCCGGCGGCGGCTGAGCCGCGCTGCGCAGCCGACGCGGGAATGAAG
CGGGCGCTGGGCAGGCGAAAGGGCGTGTGGTTGCGCCTGAGGAAGATACTTTTCTGTGTTTTGGGGTTGTACATTGCCATTCCATTTCTC
ATCAAACTATGTCCTGGAATACAGGCCAAACTGATTTTCTTGAATTTCGTAAGAGTTCCCTATTTCATTGATTTGAAAAAACCACAGGAT
CAAGGTTTGAATCACACGTGTAACTACTACCTGCAGCCAGAGGAAGACGTGACCATTGGAGTCTGGCACACCGTCCCTGCAGTCTGGTGG
AAGAACGCCCAAGGCAAAGACCAGATGTGGTATGAGGATGCCTTGGCTTCCAGCCACCCTATCATTCTGTACCTGCATGGGAACGCAGGT
ACCAGAGGAGGCGACCACCGCGTGGAGCTTTACAAGGTGCTGAGTTCCCTTGGTTACCATGTGGTCACCTTTGACTACAGAGGTTGGGGT
GACTCAGTGGGAACGCCATCTGAGCGGGGCATGACCTATGACGCACTCCACGTTTTTGACTGGATCAAAGCAAGAAGTGGTGACAACCCC
GTGTACATCTGGGGCCACTCTCTGGGCACTGGCGTGGCGACAAATCTGGTGCGGCGCCTCTGTGAGCGAGAGACGCCTCCAGATGCCCTT
ATATTGGAATCTCCATTCACTAATATCCGCGAAGAAGCTAAGAGCCATCCATTTTCAGTGATATATCGATACTTCCCTGGGTTTGACTGG
TTCTTCCTTGATCCTATTACAAGTAGTGGAATTAAATTTGCAAATGATGAAAACGTGAAGCACATCTCCTGTCCCCTGCTCATCCTGCAC
GCTGAGGACGACCCGGTGGTGCCCTTCCAGCTTGGCAGAAAGCTCTATAGCATCGCCGCACCAGCTCGAAGCTTCCGAGATTTCAAAGTT
CAGTTTGTGCCCTTTCATTCAGACCTTGGCTACAGGCACAAATACATTTACAAGAGCCCTGAGCTGCCACGGATACTGAGGGAAAAGGAC
TTGGAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATACCAGAAGGAGGCACTGGGGACTCAGGA
AGAGAACGGACCAAGACCTTCACCTATGACTTTTCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAATGGTTTTC
AAAACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCATATGGGCAAACTGGATCTGGAAAGTCA
TACACTATGATGGGAAATTCTGGAGATTCTGGCTTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCACCAGATGG
GATGAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGATCTACTTCGGCGGAAGTCATCTAAAACC
TTCAATTTGAGAGTCCGTGAGCATCCCAAAGAAGGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGACGTAGAA
GAACTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGTAGCAGGTCTCATGCCATCTTCACCATC
AAGTTCACTCAGGCTAAATTTGATTCTGAAATGCCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGAGCGTGCA
GATGCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTGACTCTGGGGAACGTCATTTCTGCCTTA
GCTGATTTATCTCAGGATGCTGCAAATACTCTTGCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTGGTTGTTA
AAAGATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTCAATTATGGAGAAACCCTAAGTACTCTT
CGCTATGCAAATAGAGCCAAAAACATCATCAACAAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCGAGCTGAA
ATAGCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACAGCTTTAAGTATGGAGGAAAAACTTCAG
CAGAATGAAGCAAGAGTTCAAGAATTGACCAAGGAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAACTCTAGCC
CTCAGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGATGATGACCTTTTGAGTACTGGAATCATC
TTATATCATTTAAAGGAAGGTCAGACATACGTTGGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGACTTGGAG
AGTGAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCCCAGTGCTCTGTGAATGGTGTTCAGATC
GTGGAGGCCACACATCTAAATCAAGGTGCTGTGATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGCCGCCAAG
CTCAGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCGAAGTCCCGTGAGAACCTGTCTGCAGTC
ATGTTGTATAACCCCGGACTTGAATTTGAGAGGCAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGAAGAAATG
GAGGAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAGCGCAAGGAGACAGAAATCGTGCAGCTC
CAGATTCGCAAGCAGGAGGAGAGCCTCAAACGCCGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGAAAAATTT
GAAGAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAGACCTTTCTCCGCGTCCAAGAAGAACTC
CAACGACTCAAAGAACTCAACAACAACGAGAAGGCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAAAGATGAA
CAGTATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATGCTCGTGGCCCATCTGGAAGAGCAGCTC
CGAGAGAAGCAGGAGATGATCCAGCTCCTGCGGCGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCATTCGGGAA
TCCCTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAGGCTCAACTGCGTTTCTTCGAATTCAAG
AGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAGAAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGAACAGGAG
ATCCTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAGAGTGTCACAGATGTCACGGAAGTGCCT
CAAGATTTCGAGAAAATAAAGCCAGTGGAGTACAGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTTGCCAACT
CTGTTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAACACTCTTTATCAAGTAGAAAAGGAAATG
GAAGAAAAAGAAGAACAGCTTGCACAGTACCAGGCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGCCAACATT
GCACGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAGCAGAGAGAGGCGCTGGAGCGGGCCCTG
GCCAGGCTGGAGAGGAGACATTCTGCGCTGCAGAGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGCCAGTCTG
AACAGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTGGAGAAGGACCAGGAGAGGTTAGAATAT
GAAATCCAGCAGCTGAAACAGAAGATTTATGAGGTCGATGGTGTTCAAAAAGATCATCATGGGACCCTGGAAGGGAAGGTGGCTTCTTCC
AGCTTGCCAGTCAGTGCTGAAAAATCACACCTGGTTCCCCTCATGGATGCCAGGATCAATGCTTACATTGAAGAAGAAGTCCAAAGACGC
CTTCAGGATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAATGAGAAACTTCACAATGGCACCATT
CAACGTAAACTAAAATATGAGCGGATGGTTTCTCGCTCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAGTATCCCA
CGCTACGTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTAGATGAGACATGGACTGTATTCAGG
CGTTACAGTCGTTTTCGAGAAATGCATAAAACATTGAAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAAACTATTT
GGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCAGTCCGCA
ACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGGAGTCTTT
GACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCCGATGCAG
GGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGTTTCCATA
CCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGAACGTGGC
CTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTTCCCTGAG
CCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAAAATATAC
TCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTTTTTCCCT
CATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATCCAATCAT
GACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTATTTAACC
TTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCAAAGCTAA
ATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTTTATTAAT
GATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAATGTGAGTG
GAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTTCCATCAA
AATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTCAAAATTTAAATTGAGCTGCTATCAATATTAAATGAAGTTATGG
CATCTA

>375_375_1_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000339157_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS
HGTG

--------------------------------------------------------------
>375_375_2_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000376542_KIF16B_chr20_16509085_ENST00000354981_length(transcript)=6493nt_BP=1437nt
GCCAGGGATGCTGGGCGCGCGCTCCTTGGAACTAGAGAGGAGGTGGCCGGGGCGGGGCCGGGGGAGGGGGGTAGGGCAGAGCCGGCGGGA
GCCCGGCGCTGATTGGCCGGCCTGGCTGGCGGGCCCCCGCCGCTGGTTCGTAGCCGGCGCAGCGGCCTGGGCTGGGATGTGAGGAGCGGC
GGGTTCCGGGCTCCGGGCTCTGGGTGGCGGCGGCTGTGAGCGGCGGCACTGCGGCGCAGGCCAGCGGGCGCCGTCGGCGGCTGGCCCTGT
CGGCCGCGGGATGAGGAAGCGGACCGAGCCCGTCGCCTTGGAGCATGAGCGCTGCGCCGCCGCGGGCTCGTCCTCCTCCGGCTCGGCCGC
CGCGGCGCTGGACGCCGACTGCCGCCTGAAGCAGAACCTACGCCTGACGGGCCCGGCGGCGGCTGAGCCGCGCTGCGCAGCCGACGCGGG
AATGAAGCGGGCGCTGGGCAGGCGAAAGGGCGTGTGGTTGCGCCTGAGGAAGATACTTTTCTGTGTTTTGGGGTTGTACATTGCCATTCC
ATTTCTCATCAAACTATGTCCTGGAATACAGGCCAAACTGATTTTCTTGAATTTCGTAAGAGTTCCCTATTTCATTGATTTGAAAAAACC
ACAGGATCAAGGTTTGAATCACACGTGTAACTACTACCTGCAGCCAGAGGAAGACGTGACCATTGGAGTCTGGCACACCGTCCCTGCAGT
CTGGTGGAAGAACGCCCAAGGCAAAGACCAGATGTGGTATGAGGATGCCTTGGCTTCCAGCCACCCTATCATTCTGTACCTGCATGGGAA
CGCAGGTACCAGAGGAGGCGACCACCGCGTGGAGCTTTACAAGGTGCTGAGTTCCCTTGGTTACCATGTGGTCACCTTTGACTACAGAGG
TTGGGGTGACTCAGTGGGAACGCCATCTGAGCGGGGCATGACCTATGACGCACTCCACGTTTTTGACTGGATCAAAGCAAGAAGTGGTGA
CAACCCCGTGTACATCTGGGGCCACTCTCTGGGCACTGGCGTGGCGACAAATCTGGTGCGGCGCCTCTGTGAGCGAGAGACGCCTCCAGA
TGCCCTTATATTGGAATCTCCATTCACTAATATCCGCGAAGAAGCTAAGAGCCATCCATTTTCAGTGATATATCGATACTTCCCTGGGTT
TGACTGGTTCTTCCTTGATCCTATTACAAGTAGTGGAATTAAATTTGCAAATGATGAAAACGTGAAGCACATCTCCTGTCCCCTGCTCAT
CCTGCACGCTGAGGACGACCCGGTGGTGCCCTTCCAGCTTGGCAGAAAGCTCTATAGCATCGCCGCACCAGCTCGAAGCTTCCGAGATTT
CAAAGTTCAGTTTGTGCCCTTTCATTCAGACCTTGGCTACAGGCACAAATACATTTACAAGAGCCCTGAGCTGCCACGGATACTGAGGGA
AAAGGACTTGGAGGCCAAGTTCATTATTCAGATGGAGAAAAGCAAAACGACAATCACAAACTTAAAGATACCAGAAGGAGGCACTGGGGA
CTCAGGAAGAGAACGGACCAAGACCTTCACCTATGACTTTTCTTTTTATTCTGCTGATACAAAAAGCCCAGATTACGTTTCACAAGAAAT
GGTTTTCAAAACCCTCGGCACAGATGTCGTGAAGTCTGCATTTGAAGGTTATAATGCTTGTGTCTTTGCATATGGGCAAACTGGATCTGG
AAAGTCATACACTATGATGGGAAATTCTGGAGATTCTGGCTTAATACCTCGGATCTGTGAAGGACTCTTCAGTCGGATAAATGAAACCAC
CAGATGGGATGAAGCTTCTTTTCGAACTGAAGTCAGCTACTTAGAAATTTATAACGAACGTGTGAGAGATCTACTTCGGCGGAAGTCATC
TAAAACCTTCAATTTGAGAGTCCGTGAGCATCCCAAAGAAGGCCCTTATGTTGAGGATTTATCCAAACATTTAGTACAGAATTATGGTGA
CGTAGAAGAACTTATGGATGCGGGCAATATCAACCGGACCACCGCAGCGACTGGGATGAACGACGTCAGTAGCAGGTCTCATGCCATCTT
CACCATCAAGTTCACTCAGGCTAAATTTGATTCTGAAATGCCATGTGAAACCGTCAGTAAGATCCACTTGGTTGATCTTGCCGGAAGTGA
GCGTGCAGATGCCACCGGAGCCACCGGGGTTAGGCTAAAGGAAGGGGGAAATATTAACAAGTCCCTCGTGACTCTGGGGAACGTCATTTC
TGCCTTAGCTGATTTATCTCAGGATGCTGCAAATACTCTTGCAAAGAAGAAGCAAGTTTTCGTGCCTTACAGGGATTCTGTGTTGACTTG
GTTGTTAAAAGATAGCCTTGGAGGAAACTCTAAAACTATCATGATTGCCACCATTTCACCTGCTGATGTCAATTATGGAGAAACCCTAAG
TACTCTTCGCTATGCAAATAGAGCCAAAAACATCATCAACAAGCCTACCATTAATGAGGATGCCAACGTCAAACTTATCCGTGAGCTGCG
AGCTGAAATAGCCAGACTGAAAACGCTGCTTGCTCAAGGGAATCAGATTGCCCTCTTAGACTCCCCCACAGCTTTAAGTATGGAGGAAAA
ACTTCAGCAGAATGAAGCAAGAGTTCAAGAATTGACCAAGGAATGGACAAATAAGTGGAATGAAACCCAAAATATTTTGAAAGAACAAAC
TCTAGCCCTCAGGAAAGAAGGGATTGGAGTTGTTTTGGATTCTGAACTGCCTCATTTGATTGGCATCGATGATGACCTTTTGAGTACTGG
AATCATCTTATATCATTTAAAGGAAGGTCAGACATACGTTGGTAGAGACGATGCTTCCACGGAGCAAGATATTGTTCTTCATGGCCTTGA
CTTGGAGAGTGAGCATTGCATCTTTGAAAATATCGGGGGGACAGTGACTCTGATACCCCTGAGTGGGTCCCAGTGCTCTGTGAATGGTGT
TCAGATCGTGGAGGCCACACATCTAAATCAAGGTGCTGTGATTCTCTTGGGAAGAACCAATATGTTTCGCTTTAACCATCCAAAGGAAGC
CGCCAAGCTCAGGGAGAAGAGGAAGAGTGGCCTTCTGTCCTCCTTCAGCTTGTCCATGACCGACCTCTCGAAGTCCCGTGAGAACCTGTC
TGCAGTCATGTTGTATAACCCCGGACTTGAATTTGAGAGGCAACAGCGTGAAGAACTTGAAAAATTAGAAAGTAAAAGGAAACTCATAGA
AGAAATGGAGGAAAAGCAGAAATCAGACAAGGCTGAACTGGAGCGGATGCAGCAGGAGGTGGAGACCCAGCGCAAGGAGACAGAAATCGT
GCAGCTCCAGATTCGCAAGCAGGAGGAGAGCCTCAAACGCCGCAGCTTCCACATCGAGAACAAGCTAAAGGATTTACTTGCGGAGAAGGA
AAAATTTGAAGAGGAGAGGCTGAGGGAACAGCAGGAAATCGAGCTGCAGAAGAAGAGACAAGAAGAAGAGACCTTTCTCCGCGTCCAAGA
AGAACTCCAACGACTCAAAGAACTCAACAACAACGAGAAGGCTGAGAAGTTTCAGATATTTCAAGAACTGGACCAGCTCCAAAAGGAAAA
AGATGAACAGTATGCCAAGCTTGAACTGGAAAAAAAGAGACTAGAGGAGCAGGAGAAGGAGCAGGTCATGCTCGTGGCCCATCTGGAAGA
GCAGCTCCGAGAGAAGCAGGAGATGATCCAGCTCCTGCGGCGTGGGGAGGTACAGTGGGTGGAAGAGGAGAAGAGGGACCTGGAAGGCAT
TCGGGAATCCCTCCTGCGGGTGAAGGAGGCTCGTGCCGGAGGGGATGAAGATGGCGAGGAGTTAGAAAAGGCTCAACTGCGTTTCTTCGA
ATTCAAGAGAAGGCAGCTTGTCAAGCTAGTGAACTTGGAGAAGGACCTGGTTCAGCAGAAAGACATCCTGAAAAAAGAAGTCCAAGAAGA
ACAGGAGATCCTAGAGTGTTTAAAATGTGAACATGACAAAGAATCTAGATTGTTGGAAAAACATGATGAGAGTGTCACAGATGTCACGGA
AGTGCCTCAAGATTTCGAGAAAATAAAGCCAGTGGAGTACAGGCTGCAATATAAAGAACGCCAGCTACAGTACCTCCTGCAGAATCACTT
GCCAACTCTGTTGGAAGAAAAGCAGAGAGCATTTGAAATTCTTGACAGAGGCCCTCTCAGCTTAGACAACACTCTTTATCAAGTAGAAAA
GGAAATGGAAGAAAAAGAAGAACAGCTTGCACAGTACCAGGCCAATGCAAACCAGCTGCAAAAGCTCCAAGCCACCTTTGAATTCACTGC
CAACATTGCACGTCAGGAGGAAAAAGTGAGGAAAAAGGAAAAGGAGATTTTGGAGTCCAGAGAGAAGCAGCAGAGAGAGGCGCTGGAGCG
GGCCCTGGCCAGGCTGGAGAGGAGACATTCTGCGCTGCAGAGGCACTCCACCCTGGGCATGGAGATTGAAGAGCAGAGGCAGAAACTTGC
CAGTCTGAACAGTGGCAGCAGAGAGCAGTCAGGGCTCCAGGCTAGCCTGGAGGCTGAGCAGGAAGCCCTGGAGAAGGACCAGGAGAGGTT
AGAATATGAAATCCAGCAGCTGAAACAGAAGATTTATGAGGTCGATGGTGTTCAAAAAGATCATCATGGGACCCTGGAAGGGAAGGTGGC
TTCTTCCAGCTTGCCAGTCAGTGCTGAAAAATCACACCTGGTTCCCCTCATGGATGCCAGGATCAATGCTTACATTGAAGAAGAAGTCCA
AAGACGCCTTCAGGATTTGCATCGTGTGATTAGTGAAGGCTGCAGTACATCTGCAGACACGATGAAGGATAATGAGAAACTTCACAATGG
CACCATTCAACGTAAACTAAAATATGAGCGGATGGTTTCTCGCTCTTTGGGCGCAAATCCAGATGACCTGAAGGACCCAATTAAAATTAG
TATCCCACGCTACGTCCTCTGCGGGCAAGGAAAGGATGCACACTTCGAGTTTGAGGTCAAGATTACTGTCCTAGATGAGACATGGACTGT
ATTCAGGCGTTACAGTCGTTTTCGAGAAATGCATAAAACATTGAAGTTAAAGTATGCAGAGCTTGCTGCCCTTGAATTTCCTCCAAAGAA
ACTATTTGGAAATAAGGATGAACGTGTGATTGCTGAGAGACGAAGTCACTTAGAGAAATACCTCAGGGACTTTTTCAGCGTGATGCTCCA
GTCCGCAACATCTCCCCTCCACATCAACAAAGTGGGACTGACTCTCTCGAAACATACCATTTGTGAGTTTTCACCATTCTTCAAGAAAGG
AGTCTTTGACTACAGCAGCCACGGGACGGGGTAGAGCCAGGGGTGATGGAGGAACCACCACAGCAGTGCCTTCTCGTCGAAGCGGGCTCC
GATGCAGGGCAGCTCCCCCATGCGAGGATCCGGGTCTGCCTCCTCCTGCTGAAGACAGACATGCAGCAGCGGGCCCGGGCCACCTCACGT
TTCCATACCTAGTGCCTGAGTTTGGGGATGGGATGCTCTGCCTGCTGATGTGGCCCTGACAGGCAGCCGTTACCGTTCCATTGCGGTTGA
ACGTGGCCTTTTCCCACAGTGCTTCCTTCTCACTGCGCAGCAAAGTTCGTCCCCTGTGGCAAGATAGATGTGGTTGGGCCATCGTGGGTT
CCCTGAGCCCAGCCAGCCTGGGACCTCCCAAAGTGGGTGGCTTACCAGACCACCCTTAAATGACTTTCATCTGGTTTCCTCTTTCACCAA
AATATACTCGTATTTTTTATATTTCTTCCATGTGGCTGGCTATATTCCAAGAAAAGCATTTTAAATTATTTCATTGTATTTTTTTCTTTT
TTTCCCTCATTTGAATCAGAACTTTTATATAAAACCCAAACACTGATGTTTACACAGAATTTCATATTCTGCAAAAGGGATTTTTTGATC
CAATCATGACTGTAGTCTTCCATGCTTGACAAATTGGATGTAGACAACATTACTTAAAACTTCTATAAATCCCTACAATTAGGATATTTA
TTTAACCTTGAATATTCAAGAACATTCTCCCAAATCTAAATGGCTACTGTGCATTCTTGAGCTTTTTCTGCTAAGCACAAAATGAACGCA
AAGCTAAATGCATATTTTTAAGTATTATTCACATTTTTTGTTACAGAATCTATTGGATCTTTGGCTGGAAAACTAGAATTTATAGCAGTT
TATTAATGATACCTTAAATTACTCAGGACTTAATGTAGCATTGCACTTCTGTGTACAGTAAAACTGCTTTGTTTTACTAAAGAGAAAAAT
GTGAGTGGAAAAAATATGTATGTGGTATATACTCAAATGTATATAATTCTATCTATAGATTTATATATGTATACATTCTGTACAGTAGTT
CCATCAAAATATGTAATAATTCACACCAATTTTATTAAATGTATTTGCTTTTTCAAAATTTAAATTGAGCTGCTATCAATATTAAATGAA
GTTATGGCATCTA

>375_375_2_ABHD12-KIF16B_ABHD12_chr20_25282855_ENST00000376542_KIF16B_chr20_16509085_ENST00000354981_length(amino acids)=1714AA_BP=412
MGGGGCERRHCGAGQRAPSAAGPVGRGMRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALG
RRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQ
GKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIW
GHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDD
PVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREKDLEAKFIIQMEKSKTTITNLKIPEGGTGDSGRERT
KTFTYDFSFYSADTKSPDYVSQEMVFKTLGTDVVKSAFEGYNACVFAYGQTGSGKSYTMMGNSGDSGLIPRICEGLFSRINETTRWDEAS
FRTEVSYLEIYNERVRDLLRRKSSKTFNLRVREHPKEGPYVEDLSKHLVQNYGDVEELMDAGNINRTTAATGMNDVSSRSHAIFTIKFTQ
AKFDSEMPCETVSKIHLVDLAGSERADATGATGVRLKEGGNINKSLVTLGNVISALADLSQDAANTLAKKKQVFVPYRDSVLTWLLKDSL
GGNSKTIMIATISPADVNYGETLSTLRYANRAKNIINKPTINEDANVKLIRELRAEIARLKTLLAQGNQIALLDSPTALSMEEKLQQNEA
RVQELTKEWTNKWNETQNILKEQTLALRKEGIGVVLDSELPHLIGIDDDLLSTGIILYHLKEGQTYVGRDDASTEQDIVLHGLDLESEHC
IFENIGGTVTLIPLSGSQCSVNGVQIVEATHLNQGAVILLGRTNMFRFNHPKEAAKLREKRKSGLLSSFSLSMTDLSKSRENLSAVMLYN
PGLEFERQQREELEKLESKRKLIEEMEEKQKSDKAELERMQQEVETQRKETEIVQLQIRKQEESLKRRSFHIENKLKDLLAEKEKFEEER
LREQQEIELQKKRQEEETFLRVQEELQRLKELNNNEKAEKFQIFQELDQLQKEKDEQYAKLELEKKRLEEQEKEQVMLVAHLEEQLREKQ
EMIQLLRRGEVQWVEEEKRDLEGIRESLLRVKEARAGGDEDGEELEKAQLRFFEFKRRQLVKLVNLEKDLVQQKDILKKEVQEEQEILEC
LKCEHDKESRLLEKHDESVTDVTEVPQDFEKIKPVEYRLQYKERQLQYLLQNHLPTLLEEKQRAFEILDRGPLSLDNTLYQVEKEMEEKE
EQLAQYQANANQLQKLQATFEFTANIARQEEKVRKKEKEILESREKQQREALERALARLERRHSALQRHSTLGMEIEEQRQKLASLNSGS
REQSGLQASLEAEQEALEKDQERLEYEIQQLKQKIYEVDGVQKDHHGTLEGKVASSSLPVSAEKSHLVPLMDARINAYIEEEVQRRLQDL
HRVISEGCSTSADTMKDNEKLHNGTIQRKLKYERMVSRSLGANPDDLKDPIKISIPRYVLCGQGKDAHFEFEVKITVLDETWTVFRRYSR
FREMHKTLKLKYAELAALEFPPKKLFGNKDERVIAERRSHLEKYLRDFFSVMLQSATSPLHINKVGLTLSKHTICEFSPFFKKGVFDYSS
HGTG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ABHD12-KIF16B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for ABHD12-KIF16B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for ABHD12-KIF16B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	ABHD12	C2675204	Polyneuropathy, Hearing Loss, Ataxia, Retinitis Pigmentosa, And Cataract	8	CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	ABHD12	C0004138	Ataxias, Hereditary	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0018784	Sensorineural Hearing Loss (disorder)	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0028738	Nystagmus	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0029124	Optic Atrophy	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0035334	Retinitis Pigmentosa	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0040822	Tremor	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0151888	Hyporeflexia	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0235259	Subcapsular cataract	1	GENOMICS_ENGLAND
Hgene	ABHD12	C0270922	Peripheral demyelinating neuropathy	1	GENOMICS_ENGLAND
Hgene	ABHD12	C1112256	Sensorimotor neuropathy	1	GENOMICS_ENGLAND
Hgene	ABHD12	C1384666	hearing impairment	1	GENOMICS_ENGLAND
Hgene	ABHD12	C1847584	Distal sensory impairment	1	GENOMICS_ENGLAND
Hgene	ABHD12	C1857640	Decreased nerve conduction velocity	1	GENOMICS_ENGLAND
Hgene	ABHD12	C1963184	Nystagmus, CTCAE 3.0	1	GENOMICS_ENGLAND
Hgene	ABHD12	C2675205	Distal muscle atrophy due to neurologic disease	1	GENOMICS_ENGLAND
Hgene	ABHD12	C2675206	Normal serum phytanic and pristanic acid	1	GENOMICS_ENGLAND
Hgene	ABHD12	C4554036	Nystagmus, CTCAE 5.0	1	GENOMICS_ENGLAND

Fusion Gene Studies in Kim Lab

Fusion gene:ABHD12-KIF16B (FusionGDB2 ID:HG26090TG55614)

Fusion Gene Summary for ABHD12-KIF16B

Fusion Gene ORF analysis for ABHD12-KIF16B

Fusion Genomic Features for ABHD12-KIF16B

Fusion Protein Features for ABHD12-KIF16B

Fusion Gene Sequence for ABHD12-KIF16B

Fusion Gene PPI Analysis for ABHD12-KIF16B

Related Drugs for ABHD12-KIF16B

Related Diseases for ABHD12-KIF16B

Fusion Gene Studies
in Kim Lab