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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GAS6-TFDP1 (FusionGDB2 ID:HG2621TG7027)

Fusion Gene Summary for GAS6-TFDP1

check button Fusion gene summary
Fusion gene informationFusion gene name: GAS6-TFDP1
Fusion gene ID: hg2621tg7027
HgeneTgene
Gene symbol

GAS6

TFDP1

Gene ID

2621

7027

Gene namegrowth arrest specific 6transcription factor Dp-1
SynonymsAXLLG|AXSFDILC|DP1|DRTF1|Dp-1
Cytomap('GAS6')('TFDP1')

13q34

13q34

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 6AXL receptor tyrosine kinase ligandAXL stimulatory factortranscription factor Dp-1DRTF1-polypeptide 1E2F dimerization partner 1E2F-related transcription factordown-regulated in liver cancer stem cells
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000327773, ENST00000357389, 
ENST00000476291, ENST00000355761, 
ENST00000418959, ENST00000450766, 
Fusion gene scores* DoF score21 X 12 X 12=302410 X 7 X 10=700
# samples 2914
** MAII scorelog2(29/3024*10)=-3.38233333420614
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/700*10)=-2.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GAS6 [Title/Abstract] AND TFDP1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGAS6(114566547)-TFDP1(114265310), # samples:1
Anticipated loss of major functional domain due to fusion event.GAS6-TFDP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS6-TFDP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS6-TFDP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS6-TFDP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGAS6

GO:0001934

positive regulation of protein phosphorylation

7854420|16723520|20103767

HgeneGAS6

GO:0006468

protein phosphorylation

16359517

HgeneGAS6

GO:0006909

phagocytosis

21501828

HgeneGAS6

GO:0007165

signal transduction

7854420|18680538

HgeneGAS6

GO:0010628

positive regulation of gene expression

19657094

HgeneGAS6

GO:0010804

negative regulation of tumor necrosis factor-mediated signaling pathway

19657094

HgeneGAS6

GO:0018105

peptidyl-serine phosphorylation

18680538|20103767

HgeneGAS6

GO:0019064

fusion of virus membrane with host plasma membrane

21501828

HgeneGAS6

GO:0019079

viral genome replication

21501828

HgeneGAS6

GO:0032689

negative regulation of interferon-gamma production

18840707

HgeneGAS6

GO:0032715

negative regulation of interleukin-6 production

19657094

HgeneGAS6

GO:0032720

negative regulation of tumor necrosis factor production

19657094|20103767

HgeneGAS6

GO:0032825

positive regulation of natural killer cell differentiation

18840707

HgeneGAS6

GO:0033138

positive regulation of peptidyl-serine phosphorylation

16723520

HgeneGAS6

GO:0035457

cellular response to interferon-alpha

19657094

HgeneGAS6

GO:0035690

cellular response to drug

16359517

HgeneGAS6

GO:0035754

B cell chemotaxis

19922767

HgeneGAS6

GO:0043066

negative regulation of apoptotic process

19922767

HgeneGAS6

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

16723520

HgeneGAS6

GO:0043277

apoptotic cell clearance

21501828

HgeneGAS6

GO:0043433

negative regulation of DNA-binding transcription factor activity

18680538

HgeneGAS6

GO:0043491

protein kinase B signaling

16723520|20103767

HgeneGAS6

GO:0045860

positive regulation of protein kinase activity

7854420

HgeneGAS6

GO:0045892

negative regulation of transcription, DNA-templated

18680538

HgeneGAS6

GO:0046718

viral entry into host cell

21501828

HgeneGAS6

GO:0046813

receptor-mediated virion attachment to host cell

21501828

HgeneGAS6

GO:0046827

positive regulation of protein export from nucleus

18680538

HgeneGAS6

GO:0048146

positive regulation of fibroblast proliferation

7854420|15184064

HgeneGAS6

GO:0050711

negative regulation of interleukin-1 secretion

20103767

HgeneGAS6

GO:0050766

positive regulation of phagocytosis

18395422

HgeneGAS6

GO:0051897

positive regulation of protein kinase B signaling

16359517|16723520|18680538

HgeneGAS6

GO:0061098

positive regulation of protein tyrosine kinase activity

20103767

HgeneGAS6

GO:0070168

negative regulation of biomineral tissue development

20048160

HgeneGAS6

GO:0070374

positive regulation of ERK1 and ERK2 cascade

15184064

HgeneGAS6

GO:0070588

calcium ion transmembrane transport

18395422

HgeneGAS6

GO:0071307

cellular response to vitamin K

16359517

HgeneGAS6

GO:0072659

protein localization to plasma membrane

16359517

HgeneGAS6

GO:0097241

hematopoietic stem cell migration to bone marrow

19922767

HgeneGAS6

GO:1900142

negative regulation of oligodendrocyte apoptotic process

16723520

HgeneGAS6

GO:1900165

negative regulation of interleukin-6 secretion

20103767

HgeneGAS6

GO:2000270

negative regulation of fibroblast apoptotic process

16359517

HgeneGAS6

GO:2000352

negative regulation of endothelial cell apoptotic process

16359517|18680538|18760998

HgeneGAS6

GO:2000510

positive regulation of dendritic cell chemotaxis

19657094

HgeneGAS6

GO:2000669

negative regulation of dendritic cell apoptotic process

19657094

TgeneTFDP1

GO:0045944

positive regulation of transcription by RNA polymerase II

7739537

TgeneTFDP1

GO:0051091

positive regulation of DNA-binding transcription factor activity

17062573

TgeneTFDP1

GO:1900087

positive regulation of G1/S transition of mitotic cell cycle

17062573


check buttonFusion gene breakpoints across GAS6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TFDP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2056GAS6chr13

114566547

-TFDP1chr13

114265310

+


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Fusion Gene ORF analysis for GAS6-TFDP1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000327773ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
5CDS-3UTRENST00000357389ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000327773ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000327773ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000357389ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
5CDS-5UTRENST00000357389ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+
5UTR-3CDSENST00000476291ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
5UTR-3UTRENST00000476291ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
5UTR-5UTRENST00000476291ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
5UTR-5UTRENST00000476291ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+
In-frameENST00000327773ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
In-frameENST00000357389ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3CDSENST00000355761ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3CDSENST00000418959ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3CDSENST00000450766ENST00000375370GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3UTRENST00000355761ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3UTRENST00000418959ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-3UTRENST00000450766ENST00000465174GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000355761ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000355761ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000418959ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000418959ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000450766ENST00000538138GAS6chr13

114566547

-TFDP1chr13

114265310

+
intron-5UTRENST00000450766ENST00000544902GAS6chr13

114566547

-TFDP1chr13

114265310

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000357389GAS6chr13114566547-ENST00000375370TFDP1chr13114265310+28324081291628499
ENST00000327773GAS6chr13114566547-ENST00000375370TFDP1chr13114265310+28264021231622499

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000357389ENST00000375370GAS6chr13114566547-TFDP1chr13114265310+0.0005360890.999464
ENST00000327773ENST00000375370GAS6chr13114566547-TFDP1chr13114265310+0.0005257770.9994742

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Fusion Genomic Features for GAS6-TFDP1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GAS6chr13114566547-TFDP1chr13114265310+7.30E-080.9999999
GAS6chr13114566547-TFDP1chr13114265310+7.30E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for GAS6-TFDP1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:114566547/chr13:114265310)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112250_2534411.0Compositional biasNote=Poly-Pro
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112394_4104411.0Compositional biasNote=Asp/Glu-rich (acidic%3B NCB domain)
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112113_1954411.0DNA bindingOntology_term=ECO:0000255
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112161_1954411.0MotifNote=DEF box
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112204_2774411.0RegionDimerization
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112211_3274411.0RegionNote=Enhances binding of RB protein to E2F
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112214_2464411.0RegionNote=DCB1
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112259_3154411.0RegionNote=DCB2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215116_15485679.0DomainEGF-like 1%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215156_19685679.0DomainEGF-like 2%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215197_23785679.0DomainEGF-like 3%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215238_27885679.0DomainEGF-like 4%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215298_47085679.0DomainLaminin G-like 1
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-215477_67085679.0DomainLaminin G-like 2
HgeneGAS6chr13:114566547chr13:114265310ENST00000327773-21553_9485679.0DomainGla
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113116_1540625.0DomainEGF-like 1%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113156_1960625.0DomainEGF-like 2%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113197_2370625.0DomainEGF-like 3%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113238_2780625.0DomainEGF-like 4%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113298_4700625.0DomainLaminin G-like 1
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-113477_6700625.0DomainLaminin G-like 2
HgeneGAS6chr13:114566547chr13:114265310ENST00000355761-11353_940625.0DomainGla
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17116_1540380.0DomainEGF-like 1%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17156_1960380.0DomainEGF-like 2%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17197_2370380.0DomainEGF-like 3%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17238_2780380.0DomainEGF-like 4%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17298_4700380.0DomainLaminin G-like 1
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-17477_6700380.0DomainLaminin G-like 2
HgeneGAS6chr13:114566547chr13:114265310ENST00000418959-1753_940380.0DomainGla
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19116_1540406.0DomainEGF-like 1%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19156_1960406.0DomainEGF-like 2%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19197_2370406.0DomainEGF-like 3%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19238_2780406.0DomainEGF-like 4%3B calcium-binding
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19298_4700406.0DomainLaminin G-like 1
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-19477_6700406.0DomainLaminin G-like 2
HgeneGAS6chr13:114566547chr13:114265310ENST00000450766-1953_940406.0DomainGla


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Fusion Gene Sequence for GAS6-TFDP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32550_32550_1_GAS6-TFDP1_GAS6_chr13_114566547_ENST00000327773_TFDP1_chr13_114265310_ENST00000375370_length(transcript)=2826nt_BP=402nt
GCTTGAGGTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCGATGTGACCTTCAGGGCCGCCAGGACGGGATGACCGGAGCCTCCGCCCCGCG
GCGCCCGCGGCTCGCCTCGGCCTCCCGGGCGCTCTGACCGCGCGTCCCCGGCCCGCCATGGCCCCTTCGCTCTCGCCCGGGCCCGCCGCC
CTGCGCCGCGCGCCGCAGCTGCTGCTGCTGCTGCTGGCCGCGGAGTGCGCGCTTGCCGCGCTGTTGCCGGCGCGCGAGGCCACGCAGTTC
CTGCGGCCCAGGCAGCGCCGCGCCTTTCAGGTCTTCGAGGAGGCCAAGCAGGGCCACCTGGAGAGGGAGTGCGTGGAGGAGCTGTGCAGC
CGCGAGGAGGCGCGGGAGGTGTTCGAGAACGACCCCGAGACGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATAGACCAG
AACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCAAAAACC
TTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTAGGAAGC
CCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAAGGAGAG
AAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTGGCAGAC
GAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGCGTCTAC
GATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCGGCTCAG
GAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTACAGCAA
ATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCACCTGCCC
TTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGACAACACA
TTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGACCTTAAA
ATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACGACGGCA
GGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGGTCTCAG
TACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAGGACGAC
TGACGTCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCCTTTTGG
CCTACTCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGACGTGCT
GTGGATGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTCTTTAAG
TGCAGAGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAACACCTCC
TGTTGTGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGGAGTTTG
TTCAGTGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAACAATAAA
CACCATCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCCCTGTTT
TGCAGCAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGACTGTCTG
GAAGGCTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTTGTTTAC
ATACTTATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAATTGAAA
TTAAATATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAAGGAATT
TAAGGACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACGATAGTC
TTTTTATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGCACTGTT

>32550_32550_1_GAS6-TFDP1_GAS6_chr13_114566547_ENST00000327773_TFDP1_chr13_114265310_ENST00000375370_length(amino acids)=499AA_BP=61
MTARPRPAMAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFEND
PETAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQ
NQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNI
ISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTV
IDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSA

--------------------------------------------------------------
>32550_32550_2_GAS6-TFDP1_GAS6_chr13_114566547_ENST00000357389_TFDP1_chr13_114265310_ENST00000375370_length(transcript)=2832nt_BP=408nt
CCGAGCGCTTGAGGTGCCGCAGCCGCCGCCGCCGCCGCCGCCGCGATGTGACCTTCAGGGCCGCCAGGACGGGATGACCGGAGCCTCCGC
CCCGCGGCGCCCGCGGCTCGCCTCGGCCTCCCGGGCGCTCTGACCGCGCGTCCCCGGCCCGCCATGGCCCCTTCGCTCTCGCCCGGGCCC
GCCGCCCTGCGCCGCGCGCCGCAGCTGCTGCTGCTGCTGCTGGCCGCGGAGTGCGCGCTTGCCGCGCTGTTGCCGGCGCGCGAGGCCACG
CAGTTCCTGCGGCCCAGGCAGCGCCGCGCCTTTCAGGTCTTCGAGGAGGCCAAGCAGGGCCACCTGGAGAGGGAGTGCGTGGAGGAGCTG
TGCAGCCGCGAGGAGGCGCGGGAGGTGTTCGAGAACGACCCCGAGACGGCCGGTCTAATTGAAGCCAACGGAGAACTCAAGGTCTTCATA
GACCAGAACCTTAGTCCCGGGAAAGGCGTGGTGTCCCTCGTGGCCGTTCACCCCTCCACCGTCAACCCGCTCGGGAAGCAGCTCTTGCCA
AAAACCTTTGGACAGTCCAATGTCAACATTGCCCAGCAAGTGGTAATTGGTACGCCTCAGAGACCGGCAGCGTCAAACACCCTGGTGGTA
GGAAGCCCACACACCCCCAGCACTCACTTTGCCTCTCAGAACCAGCCTTCCGACTCCTCACCTTGGTCTGCCGGGAAGCGCAACAGGAAA
GGAGAGAAGAATGGCAAGGGCCTACGGCATTTCTCCATGAAGGTCTGCGAGAAGGTGCAGAGGAAAGGGACCACTTCCTACAACGAAGTG
GCAGACGAGCTGGTTGCGGAGTTCAGTGCTGCCGACAACCACATCTTACCAAACGAGTCAGCTTATGACCAGAAAAACATAAGACGGCGC
GTCTACGATGCCTTAAACGTGCTAATGGCCATGAACATCATCTCCAAGGAGAAGAAGGAGATCAAGTGGATTGGTCTGCCCACCAACTCG
GCTCAGGAATGTCAGAACTTAGAGGTGGAAAGACAGAGGAGACTTGAAAGAATAAAACAGAAACAGTCTCAACTTCAAGAACTTATTCTA
CAGCAAATTGCCTTCAAGAACCTGGTGCAGAGAAACCGGCATGCGGAGCAGCAGGCCAGCCGGCCACCGCCACCCAACTCAGTCATCCAC
CTGCCCTTCATCATCGTCAACACCAGCAAGAAGACGGTCATCGACTGCAGCATCTCCAATGACAAATTTGAGTATCTGTTTAATTTTGAC
AACACATTTGAAATCCACGATGACATAGAAGTGCTGAAGCGGATGGGCATGGCTTGCGGGCTGGAGTCGGGGAGCTGCTCTGCCGAAGAC
CTTAAAATGGCCAGAAGTCTGGTCCCCAAGGCTCTGGAGCCATACGTGACAGAAATGGCTCAGGGAACTGTTGGAGGCGTGTTCATCACG
ACGGCAGGTTCCACGTCTAACGGCACAAGGTTCTCTGCCAGTGACCTGACCAACGGTGCAGATGGGATGCTGGCCACAAGCTCCAATGGG
TCTCAGTACAGCGGCTCCAGGGTGGAGACTCCGGTGTCCTACGTCGGGGAGGACGACGAGGAGGACGATGACTTCAACGAGAATGACGAG
GACGACTGACGTCCTCCCCACTTCAGATTCGGCTTCAGGAAAACGTTTAGCGAAAAGAAACTTTTTTTTTAATGTGGGTTTTCTGTTTCC
TTTTGGCCTACTCCCAAGAAGATATTGGTAAGCTATTGAATTTAGATATGCACCTCTGATAAGCAAGGATTGTTTCCCGTAGGATTAGGA
CGTGCTGTGGATGTGTGTTTTGATACCAGTGTGCTGATGCAGAGCGTTTATTTACTTGTTAGGATTTTGTGTTTTCATTTGCTATTTTTC
TTTAAGTGCAGAGTTCATTTTTGCCCCTGAAAAGTTTTTGCTGAGTTTGCTGAAGAAATTGTATTTCAACCACATCCATGAAAATAAAAC
ACCTCCTGTTGTGGATGGTGAGCCCCTGATGCCGCTTATTTGCCGTGAGTTTGGACGGCACCCCTGCTGGCGGATAGCAAGACTCTGTGG
AGTTTGTTCAGTGGTACGGTGTCCAAGCAAACAGCAGAATGCAACTTTCTAAACAGCCCCAAGCAAACAGCAGAATTCAACTTTTTAAAC
AATAAACACCATCAACCTTATTGACTTTATTGTCCCTTAAATTATATTGACTGTTGTGATTCCATCAAGTTTGTACACTCTTTTCTCTCC
CTGTTTTGCAGCAACAAATTGCGAAGTGCTTTTGTTTGTTTGTTTTCGTTTGGTTAAAGCTTATTGCCATGCTGGTGCGGCTATGGAGAC
TGTCTGGAAGGCTTGGAATGGTTTATTGCTTATGGTAAAATTTGCCTGATTTCTTACAGGCAGCGTTTGGAAACCTTTTATTATATAGTT
GTTTACATACTTATAAGTCTATCATTTAAAGACATGTACTGAAACAAATGTATTTGTTTCATAAGCATCTTCCTGTAATCTATTATAAAA
TTGAAATTAAATATAGAGAATGTTTTAACAATTTTTTAACTCAAAATTTGTCAATCATTTTTAATAGTTCTTTTTTTATAAAAAGAAAAA
GGAATTTAAGGACAGGCAGTAGTCTCTTTTAAAATTTATTCACAAAACCCATTAACTGCACAGTTGCTATTAGCTGCCTGTTCTAAAACG
ATAGTCTTTTTATTGAAACACAAATAAACTTTTCTGTAATATTTTATGGTATATAAAGAGACTTTAATTGTTTGACTTGTTTAACTTGGC

>32550_32550_2_GAS6-TFDP1_GAS6_chr13_114566547_ENST00000357389_TFDP1_chr13_114265310_ENST00000375370_length(amino acids)=499AA_BP=61
MTARPRPAMAPSLSPGPAALRRAPQLLLLLLAAECALAALLPAREATQFLRPRQRRAFQVFEEAKQGHLERECVEELCSREEAREVFEND
PETAGLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNPLGKQLLPKTFGQSNVNIAQQVVIGTPQRPAASNTLVVGSPHTPSTHFASQ
NQPSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNI
ISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRHAEQQASRPPPPNSVIHLPFIIVNTSKKTV
IDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGSCSAEDLKMARSLVPKALEPYVTEMAQGTVGGVFITTAGSTSNGTRFSA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for GAS6-TFDP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTFDP1chr13:114566547chr13:114265310ENST00000375370112105_1274.0411.0CEBPA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GAS6-TFDP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GAS6-TFDP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS6C0040053Thrombosis4CTD_human
HgeneGAS6C0087086Thrombus4CTD_human
HgeneGAS6C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneGAS6C0011881Diabetic Nephropathy1CTD_human
HgeneGAS6C0017667Nodular glomerulosclerosis1CTD_human
HgeneGAS6C0018800Cardiomegaly1CTD_human
HgeneGAS6C0022660Kidney Failure, Acute1CTD_human
HgeneGAS6C0036095Salivary Gland Neoplasms1CTD_human
HgeneGAS6C0040038Thromboembolism1CTD_human
HgeneGAS6C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneGAS6C1383860Cardiac Hypertrophy1CTD_human
HgeneGAS6C1565662Acute Kidney Insufficiency1CTD_human
HgeneGAS6C2609414Acute kidney injury1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human