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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GCNT2-OSM (FusionGDB2 ID:HG2651TG5008)

Fusion Gene Summary for GCNT2-OSM

check button Fusion gene summary
Fusion gene informationFusion gene name: GCNT2-OSM
Fusion gene ID: hg2651tg5008
HgeneTgene
Gene symbol

GCNT2

OSM

Gene ID

2651

5008

Gene nameglucosaminyl (N-acetyl) transferase 2 (I blood group)oncostatin M
SynonymsCCAT|CTRCT13|GCNT2C|GCNT5|IGNT|II|NACGT1|NAGCT1|ULG3|bA360O19.2|bA421M1.1-
Cytomap('GCNT2')('OSM')

6p24.3-p24.2

22q12.2

Type of geneprotein-codingprotein-coding
DescriptionN-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferaseI beta-1,6-N-acetylglucosaminyltransferaseIi blood groupbeta-1,6-N-acetylglucosaminyltransferase 2glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)oncostatin-M
Modification date2020032920200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000397423, ENST00000379597, 
ENST00000495262, ENST00000265012, 
ENST00000316170, ENST00000410107, 
Fusion gene scores* DoF score8 X 7 X 6=3361 X 1 X 1=1
# samples 91
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: GCNT2 [Title/Abstract] AND OSM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGCNT2(10529074)-OSM(30661133), # samples:1
GCNT2(10530069)-OSM(30661133), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOSM

GO:0008284

positive regulation of cell proliferation

8999038

TgeneOSM

GO:0033138

positive regulation of peptidyl-serine phosphorylation

7508917

TgeneOSM

GO:0038165

oncostatin-M-mediated signaling pathway

8999038

TgeneOSM

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

21912637

TgeneOSM

GO:0043410

positive regulation of MAPK cascade

7508917

TgeneOSM

GO:0045944

positive regulation of transcription by RNA polymerase II

7508917

TgeneOSM

GO:0046888

negative regulation of hormone secretion

7867561

TgeneOSM

GO:0050729

positive regulation of inflammatory response

28972028

TgeneOSM

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

7508917|8999038

TgeneOSM

GO:1905078

positive regulation of interleukin-17 secretion

28972028


check buttonFusion gene breakpoints across GCNT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across OSM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6978-01AGCNT2chr6

10529074

+OSMchr22

30661133

-
ChimerDB4LUADTCGA-55-6978-01AGCNT2chr6

10530069

-OSMchr22

30661133

-


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Fusion Gene ORF analysis for GCNT2-OSM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000397423ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
3UTR-5UTRENST00000397423ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
3UTR-intronENST00000397423ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
5CDS-5UTRENST00000379597ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
5CDS-5UTRENST00000495262ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
5CDS-intronENST00000379597ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-
5CDS-intronENST00000495262ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-
5UTR-3CDSENST00000379597ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
5UTR-3CDSENST00000495262ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
5UTR-5UTRENST00000379597ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
5UTR-5UTRENST00000495262ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
5UTR-intronENST00000379597ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
5UTR-intronENST00000495262ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
In-frameENST00000379597ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
In-frameENST00000495262ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-3CDSENST00000265012ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-3CDSENST00000265012ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-3CDSENST00000316170ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-3CDSENST00000316170ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-3CDSENST00000397423ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-3CDSENST00000410107ENST00000215781GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-3CDSENST00000410107ENST00000215781GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-5UTRENST00000265012ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-5UTRENST00000265012ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-5UTRENST00000316170ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-5UTRENST00000316170ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-5UTRENST00000397423ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-5UTRENST00000410107ENST00000403389GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-5UTRENST00000410107ENST00000403389GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-intronENST00000265012ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-intronENST00000265012ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-intronENST00000316170ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-intronENST00000316170ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-intronENST00000397423ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-
intron-intronENST00000410107ENST00000403463GCNT2chr6

10529074

+OSMchr22

30661133

-
intron-intronENST00000410107ENST00000403463GCNT2chr6

10530069

-OSMchr22

30661133

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000495262GCNT2chr610530069-ENST00000215781OSMchr2230661133-323914605352184549
ENST00000379597GCNT2chr610530069-ENST00000215781OSMchr2230661133-326014815562205549

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000495262ENST00000215781GCNT2chr610530069-OSMchr2230661133-0.0066459050.9933541
ENST00000379597ENST00000215781GCNT2chr610530069-OSMchr2230661133-0.0077954120.99220467

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Fusion Genomic Features for GCNT2-OSM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GCNT2-OSM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:10529074/chr22:30661133)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCNT2chr6:10530069chr22:30661133ENST00000379597-131_7308403.0Topological domainCytoplasmic
HgeneGCNT2chr6:10530069chr22:30661133ENST00000495262-351_7308403.0Topological domainCytoplasmic
HgeneGCNT2chr6:10530069chr22:30661133ENST00000379597-138_23308403.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneGCNT2chr6:10530069chr22:30661133ENST00000495262-358_23308403.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCNT2chr6:10530069chr22:30661133ENST00000379597-1324_400308403.0Topological domainLumenal
HgeneGCNT2chr6:10530069chr22:30661133ENST00000495262-3524_400308403.0Topological domainLumenal


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Fusion Gene Sequence for GCNT2-OSM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>32793_32793_1_GCNT2-OSM_GCNT2_chr6_10530069_ENST00000379597_OSM_chr22_30661133_ENST00000215781_length(transcript)=3260nt_BP=1481nt
ATATCTCTCCAGGCAGTATTCACATGCTTTAAACTGAAGCTCGTAGCTTGGCAGTGCAGTTTAAGCAAATAAACTCAGGCTGTTGAACAC
AATGATTAACAGGAAGCAGGGGAGGGGACATAGTTACTAGACTCTGGCCGGGACAAGAGGCTGAGGTTAAGGTCTTAGAGCCGATGACTT
GCAGAATGGTCACCTCACCCACTTGTAATTTCATGGTGGGAACAGGTGGACCCCCTGGAATCAGAACCTCTCTGAGGACATCTGTTTTTG
TGTAGACACAGGTTGCAGGTTAGCAGGAGAACAGGCAAGCCAAATGCAAAGGAGCCACTTCAGAAATGTGTCACAGAAAAGTGAAAATGC
AACCTAGTGGTAAGTGAAGAGGGGAAGAAGAAAGAAAAAGGACCAGAACCGTGAACTGAAGGGACAGGGAACAGCCAGACGAGAGCTTCA
GCCATCACGAGGATGATTTCGGAACCTGGAGAAAATGTAAGTTAAATATATCTACACTCTGATCCTATCTCAAGAGAGAGATATTTTACT
CATTTCCTGGTTGTGAATGATGGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAA
TACTGAGTTATGGGAGAATAAACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGG
GAAAGTTTTTTACCCAACAGAAAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAAC
AGAAACACTCTCTGAAGAAGAGGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAG
GGCGATTTATATGCCCCAAAATGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAG
CTGCTTCCCAAATGCTTTTCTGGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGA
AGACCTTGTGGCCTCTGAAGTTCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCA
GTATCTGAAGGGATTTAAAGGGAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGA
ACTGTTAAACCACAAAAATTCCTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGC
CTACGTGGCTCTCACAAGGGACTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAG
CCCCGACGAACATTTCTGGGTGACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTAT
AGGCAGCTGCTCGAAAGAGTACCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCC
CTATATACGTATCCAAGGCCTGGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAG
GGGGCTGGGCAGGCGGGGCTTCCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCC
CAAGGCCCAGGATTTGGAGAGGTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAA
CAACATCTACTGCATGGCCCAGCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCC
CACCCCTGCCTCGGATGCTTTTCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGT
CTTCAGCAAGTGGGGGGAGAGCCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTC
CAGGAAAGGCAAGAGACTCATGACCAGGGGACAGCTGCCCCGGTAGCCTCGAGAGCACCCCTTGCCGGTGAAGGATGCGGCAGGTGCTCT
GTGGATGAGAGGAACCATCGCAGGATGACAGCTCCCGGGTCCCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACTTTAAG
AGGTGGGAGCTGGGCAGACCCCTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGTTGCGCTCCCACCTCAGCCCCAAGTTCCCCAG
GCCCAGTGGGGTGGCCGGGCGGGCCACGCGGGACCGACTTTCCATTGATTCAGGGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGA
CTGCCCCCCTGCCTTGCTCCCCGAGGCCTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCAGACTTCCTCCTTTCCGTGT
TTCTGAAGGGGAGGTCACAGCCTGAGCTGGCCTCCTATGCCTCATCATGTCCCAAACCAGACACCTGGATGTCTGGGTGACCTCACTTTA
GGCAGCTGTAACAGCGGCAGGGTGTCCCAGGAGCCCTGATCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCGAAGTCGC
CACGTGGCCTGGGGCAGGTCACTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGCTAGGGAGTTAGAGGCTGTACAAGGCCCCCACTG
CCTGTCGGTTGCTTGGATTCCCTGACGTAAGGTGGATATTAAAAATCTGTAAATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTAC
ACGGAGGTCTCTGTAAAAGCAGACCCACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGGCTGCTCCCCCTGGTGGTGGAT
CCTGGAATTTTCTCACGCAGGAGCCATTGCTCTCCTAGAGGGGGTCTCAGAAACTGCGAGGCCAGTTCCTTGGAGGGACATGACTAATTT
ATCGATTTTTATCAATTTTTATCAGTTTTATATTTATAAGCCTTATTTATGATGTATATTTAATGTTAATATTGTGCAAACTTATATTTA
AAACTTGCCTGGTTTCTAAA

>32793_32793_1_GCNT2-OSM_GCNT2_chr6_10530069_ENST00000379597_OSM_chr22_30661133_ENST00000215781_length(amino acids)=549AA_BP=308
MMGSWKHCLFSASLISALIFVFVYNTELWENKRFLRAALSNASLLAEACHQIFEGKVFYPTENALKTTLDEATCYEYMVRSHYVTETLSE
EEAGFPLAYTVTIHKDFGTFERLFRAIYMPQNVYCVHLDQKATDAFKGAVKQLLSCFPNAFLASKKESVVYGGISRLQADLNCLEDLVAS
EVPWKYVINTCGQDFPLKTNREIVQYLKGFKGKNITPGVLPPDHAVGRTKYVHQELLNHKNSYVIKTTKLKTPPPHDMVIYFGTAYVALT
RDFANFVLQDQLALDLLSWSKDTYSPDEHFWVTLNRIPGLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQ
GLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCM
AQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKR
LMTRGQLPR

--------------------------------------------------------------
>32793_32793_2_GCNT2-OSM_GCNT2_chr6_10530069_ENST00000495262_OSM_chr22_30661133_ENST00000215781_length(transcript)=3239nt_BP=1460nt
AAACAGGCTTACTGTGTTCACTGCTGGACGCCTCTGGGCAATCTTACCCTCCTGGGAACTGAGAGAGACAATGCTAGGAGCCAGAAACAT
GAGGAATACATGAGCTCGGCGCCAATGGAACATGCTTTCACACCGGGTGCAGCTAACCACCACATCATACAAAACTCGTCGCTGACGTTT
TAGATGTATAATCTGATTGGCATGGACTCACAGAGGAGGGAGTAAGGGAAGAGTAAGAAGATTTCAAAGGAGAGACACAGGTTGCAGGTT
AGCAGGAGAACAGGCAAGCCAAATGCAAAGGAGCCACTTCAGAAATGTGTCACAGAAAAGTGAAAATGCAACCTAGTGGTAAGTGAAGAG
GGGAAGAAGAAAGAAAAAGGACCAGAACCGTGAACTGAAGGGACAGGGAACAGCCAGACGAGAGCTTCAGCCATCACGAGGATGATTTCG
GAACCTGGAGAAAATGTAAGTTAAATATATCTACACTCTGATCCTATCTCAAGAGAGAGATATTTTACTCATTTCCTGGTTGTGAATGAT
GGGCTCTTGGAAGCACTGTCTTTTTAGCGCGTCTCTTATCTCTGCCCTGATTTTTGTATTTGTTTACAATACTGAGTTATGGGAGAATAA
ACGTTTTCTGAGGGCAGCTCTGTCCAATGCTTCACTGTTAGCAGAAGCCTGTCATCAGATTTTTGAGGGGAAAGTTTTTTACCCAACAGA
AAATGCATTGAAAACTACCCTTGATGAAGCTACCTGCTATGAGTACATGGTTCGAAGCCACTATGTAACAGAAACACTCTCTGAAGAAGA
GGCTGGGTTCCCTTTAGCTTACACAGTGACCATCCACAAAGACTTCGGCACTTTTGAGAGGCTCTTCAGGGCGATTTATATGCCCCAAAA
TGTCTACTGTGTGCACCTGGATCAGAAGGCGACGGATGCCTTTAAAGGTGCAGTGAAACAGTTACTCAGCTGCTTCCCAAATGCTTTTCT
GGCTTCCAAGAAGGAGTCGGTTGTCTATGGGGGGATCTCCAGGCTCCAGGCTGACCTGAACTGCCTGGAAGACCTTGTGGCCTCTGAAGT
TCCCTGGAAGTATGTCATCAACACCTGCGGGCAAGACTTTCCCCTGAAAACCAACAGGGAAATAGTTCAGTATCTGAAGGGATTTAAAGG
GAAAAATATCACCCCCGGAGTGCTGCCTCCTGACCACGCTGTTGGACGGACTAAATACGTCCACCAAGAACTGTTAAACCACAAAAATTC
CTACGTGATTAAAACAACAAAATTAAAAACTCCTCCTCCTCATGACATGGTGATTTACTTTGGCACGGCCTACGTGGCTCTCACAAGGGA
CTTTGCTAACTTCGTCCTCCAAGACCAGCTCGCACTTGACTTACTCTCCTGGTCCAAGGACACCTACAGCCCCGACGAACATTTCTGGGT
GACACTCAACAGGATTCCCGGTCTGGTCCTTGCACTCCTGTTTCCAAGCATGGCGAGCATGGCGGCTATAGGCAGCTGCTCGAAAGAGTA
CCGCGTGCTCCTTGGCCAGCTCCAGAAGCAGACAGATCTCATGCAGGACACCAGCAGACTCCTGGACCCCTATATACGTATCCAAGGCCT
GGATGTTCCTAAACTGAGAGAGCACTGCAGGGAGCGCCCCGGGGCCTTCCCCAGTGAGGAGACCCTGAGGGGGCTGGGCAGGCGGGGCTT
CCTGCAGACCCTCAATGCCACACTGGGCTGCGTCCTGCACAGACTGGCCGACTTAGAGCAGCGCCTCCCCAAGGCCCAGGATTTGGAGAG
GTCTGGGCTGAACATCGAGGACTTGGAGAAGCTGCAGATGGCGAGGCCGAACATCCTCGGGCTCAGGAACAACATCTACTGCATGGCCCA
GCTGCTGGACAACTCAGACACGGCTGAGCCCACGAAGGCTGGCCGGGGGGCCTCTCAGCCGCCCACCCCCACCCCTGCCTCGGATGCTTT
TCAGCGCAAGCTGGAGGGCTGCAGGTTCCTGCATGGCTACCATCGCTTCATGCACTCAGTGGGGCGGGTCTTCAGCAAGTGGGGGGAGAG
CCCGAACCGGAGCCGGAGACACAGCCCCCACCAGGCCCTGAGGAAGGGGGTGCGCAGGACCAGACCCTCCAGGAAAGGCAAGAGACTCAT
GACCAGGGGACAGCTGCCCCGGTAGCCTCGAGAGCACCCCTTGCCGGTGAAGGATGCGGCAGGTGCTCTGTGGATGAGAGGAACCATCGC
AGGATGACAGCTCCCGGGTCCCCAAACCTGTTCCCCTCTGCTACTAGCCACTGAGAAGTGCACTTTAAGAGGTGGGAGCTGGGCAGACCC
CTCTACCTCCTCCAGGCTGGGAGACAGAGTCAGGCTGTTGCGCTCCCACCTCAGCCCCAAGTTCCCCAGGCCCAGTGGGGTGGCCGGGCG
GGCCACGCGGGACCGACTTTCCATTGATTCAGGGGTCTGATGACACAGGCTGACTCATGGCCGGGCTGACTGCCCCCCTGCCTTGCTCCC
CGAGGCCTGCCGGTCCTTCCCTCTCATGACTTGCAGGGCCGTTGCCCCCAGACTTCCTCCTTTCCGTGTTTCTGAAGGGGAGGTCACAGC
CTGAGCTGGCCTCCTATGCCTCATCATGTCCCAAACCAGACACCTGGATGTCTGGGTGACCTCACTTTAGGCAGCTGTAACAGCGGCAGG
GTGTCCCAGGAGCCCTGATCCGGGGGTCCAGGGAATGGAGCTCAGGTCCCAGGCCAGCCCCGAAGTCGCCACGTGGCCTGGGGCAGGTCA
CTTTACCTCTGTGGACCTGTTTTCTCTTTGTGAAGCTAGGGAGTTAGAGGCTGTACAAGGCCCCCACTGCCTGTCGGTTGCTTGGATTCC
CTGACGTAAGGTGGATATTAAAAATCTGTAAATCAGGACAGGTGGTGCAAATGGCGCTGGGAGGTGTACACGGAGGTCTCTGTAAAAGCA
GACCCACCTCCCAGCGCCGGGAAGCCCGTCTTGGGTCCTCGCTGCTGGCTGCTCCCCCTGGTGGTGGATCCTGGAATTTTCTCACGCAGG
AGCCATTGCTCTCCTAGAGGGGGTCTCAGAAACTGCGAGGCCAGTTCCTTGGAGGGACATGACTAATTTATCGATTTTTATCAATTTTTA
TCAGTTTTATATTTATAAGCCTTATTTATGATGTATATTTAATGTTAATATTGTGCAAACTTATATTTAAAACTTGCCTGGTTTCTAAA

>32793_32793_2_GCNT2-OSM_GCNT2_chr6_10530069_ENST00000495262_OSM_chr22_30661133_ENST00000215781_length(amino acids)=549AA_BP=308
MMGSWKHCLFSASLISALIFVFVYNTELWENKRFLRAALSNASLLAEACHQIFEGKVFYPTENALKTTLDEATCYEYMVRSHYVTETLSE
EEAGFPLAYTVTIHKDFGTFERLFRAIYMPQNVYCVHLDQKATDAFKGAVKQLLSCFPNAFLASKKESVVYGGISRLQADLNCLEDLVAS
EVPWKYVINTCGQDFPLKTNREIVQYLKGFKGKNITPGVLPPDHAVGRTKYVHQELLNHKNSYVIKTTKLKTPPPHDMVIYFGTAYVALT
RDFANFVLQDQLALDLLSWSKDTYSPDEHFWVTLNRIPGLVLALLFPSMASMAAIGSCSKEYRVLLGQLQKQTDLMQDTSRLLDPYIRIQ
GLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNATLGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCM
AQLLDNSDTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNRSRRHSPHQALRKGVRRTRPSRKGKR
LMTRGQLPR

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Fusion Gene PPI Analysis for GCNT2-OSM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GCNT2-OSM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GCNT2-OSM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGCNT2C0266539Congenital total cataract2ORPHANET
HgeneGCNT2C3805373CATARACT 13 WITH ADULT i PHENOTYPE1CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0011616Contact Dermatitis1CTD_human
TgeneC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneC0027627Neoplasm Metastasis1CTD_human
TgeneC0087031Juvenile-Onset Still Disease1CTD_human
TgeneC0162351Contact hypersensitivity1CTD_human
TgeneC0263454Chloracne1CTD_human
TgeneC3495559Juvenile arthritis1CTD_human
TgeneC3714758Juvenile psoriatic arthritis1CTD_human
TgeneC4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
TgeneC4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human