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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:LATS2-MYLK (FusionGDB2 ID:HG26524TG4638)

Fusion Gene Summary for LATS2-MYLK

check button Fusion gene summary
Fusion gene informationFusion gene name: LATS2-MYLK
Fusion gene ID: hg26524tg4638
HgeneTgene
Gene symbol

LATS2

MYLK

Gene ID

26524

4638

Gene namelarge tumor suppressor kinase 2myosin light chain kinase
SynonymsKPMAAT7|KRP|MLCK|MLCK1|MLCK108|MLCK210|MMIHS|MSTP083|MYLK1|smMLCK
Cytomap('LATS2')('MYLK')

13q12.11

3q21.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-prmyosin light chain kinase, smooth musclekinase-related proteinmyosin, light polypeptide kinasesmooth muscle myosin light chain kinasetelokin
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000382592, ENST00000472754, 
ENST00000542899, 
Fusion gene scores* DoF score4 X 6 X 3=7214 X 15 X 4=840
# samples 515
** MAII scorelog2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: LATS2 [Title/Abstract] AND MYLK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointLATS2(21635485)-MYLK(123386034), # samples:5
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLATS2

GO:0000082

G1/S transition of mitotic cell cycle

12853976

HgeneLATS2

GO:0006468

protein phosphorylation

10871863

HgeneLATS2

GO:0009755

hormone-mediated signaling pathway

15131260

HgeneLATS2

GO:0035329

hippo signaling

20412773

HgeneLATS2

GO:0035556

intracellular signal transduction

10871863

HgeneLATS2

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

12853976

TgeneMYLK

GO:0030335

positive regulation of cell migration

19826488

TgeneMYLK

GO:0051928

positive regulation of calcium ion transport

16284075

TgeneMYLK

GO:0071476

cellular hypotonic response

11976941

TgeneMYLK

GO:0090303

positive regulation of wound healing

15825080



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-K1-A42X-01ALATS2chr13

21634332

-MYLKchr3

123386033

-
ChimerDB4SARCTCGA-K1-A42X-01ALATS2chr13

21635485

-MYLKchr3

123386034

-
ChimerDB4SARCTCGA-K1-A42X-02ALATS2chr13

21634332

-MYLKchr3

123386033

-
ChimerDB4SARCTCGA-K1-A42X-02ALATS2chr13

21635485

-MYLKchr3

123386034

-
ChimerDB4SARCTCGA-K1-A42XLATS2chr13

21635484

-MYLKchr3

123386034

-


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Fusion Gene ORF analysis for LATS2-MYLK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000382592ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-3CDSENST00000382592ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-5UTRENST00000382592ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-5UTRENST00000382592ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
5UTR-intronENST00000382592ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000382592ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000382592ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000382592ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000472754ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000359169LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360304LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-3CDSENST00000542899ENST00000360772LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-5UTRENST00000382592ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000472754ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-5UTRENST00000542899ENST00000510775LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000382592ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000382592ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000472754ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000346322LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000354792LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000418370LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000475616LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000578202LATS2chr13

21635484

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21634332

-MYLKchr3

123386033

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21635485

-MYLKchr3

123386034

-
intron-intronENST00000542899ENST00000583087LATS2chr13

21635484

-MYLKchr3

123386034

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for LATS2-MYLK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for LATS2-MYLK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21635485/:123386034)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for LATS2-MYLK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for LATS2-MYLK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for LATS2-MYLK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for LATS2-MYLK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneLATS2C0004114Astrocytoma1CTD_human
HgeneLATS2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
HgeneLATS2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
HgeneLATS2C0280785Diffuse Astrocytoma1CTD_human
HgeneLATS2C0334579Anaplastic astrocytoma1CTD_human
HgeneLATS2C0334580Protoplasmic astrocytoma1CTD_human
HgeneLATS2C0334581Gemistocytic astrocytoma1CTD_human
HgeneLATS2C0334582Fibrillary Astrocytoma1CTD_human
HgeneLATS2C0334583Pilocytic Astrocytoma1CTD_human
HgeneLATS2C0338070Childhood Cerebral Astrocytoma1CTD_human
HgeneLATS2C0547065Mixed oligoastrocytoma1CTD_human
HgeneLATS2C0750935Cerebral Astrocytoma1CTD_human
HgeneLATS2C0750936Intracranial Astrocytoma1CTD_human
HgeneLATS2C1704230Grade I Astrocytoma1CTD_human
TgeneC4707243Familial thoracic aortic aneurysm and aortic dissection6CLINGEN;GENOMICS_ENGLAND
TgeneC3151077AORTIC ANEURYSM, FAMILIAL THORACIC 73CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0027626Neoplasm Invasiveness2CTD_human
TgeneC0027627Neoplasm Metastasis2CTD_human
TgeneC0006114Cerebral Edema1CTD_human
TgeneC0017178Gastrointestinal Diseases1CTD_human
TgeneC0017601Glaucoma1CTD_human
TgeneC0017638Glioma1CTD_human
TgeneC0020443Hypercholesterolemia1CTD_human
TgeneC0020517Hypersensitivity1CTD_human
TgeneC0032285Pneumonia1CTD_human
TgeneC0032300Lobar Pneumonia1CTD_human
TgeneC0042373Vascular Diseases1CTD_human
TgeneC0242488Acute Lung Injury1CTD_human
TgeneC0259783mixed gliomas1CTD_human
TgeneC0345050Congenital aneurysm of ascending aorta1GENOMICS_ENGLAND
TgeneC0472387Vasogenic Cerebral Edema1CTD_human
TgeneC0472388Cytotoxic Cerebral Edema1CTD_human
TgeneC0555198Malignant Glioma1CTD_human
TgeneC0559031Functional Gastrointestinal Disorders1CTD_human
TgeneC0750969Vasogenic Brain Edema1CTD_human
TgeneC0750970Cytotoxic Brain Edema1CTD_human
TgeneC0887898Experimental Lung Inflammation1CTD_human
TgeneC1527304Allergic Reaction1CTD_human
TgeneC1527311Brain Edema1CTD_human
TgeneC1565321Cholera Infantum1CTD_human
TgeneC1608393Megacystis microcolon intestinal hypoperistalsis syndrome1GENOMICS_ENGLAND;ORPHANET
TgeneC3714636Pneumonitis1CTD_human