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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:LATS2-TNFSF4 (FusionGDB2 ID:HG26524TG7292) |
Fusion Gene Summary for LATS2-TNFSF4 |
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Fusion gene information | Fusion gene name: LATS2-TNFSF4 | Fusion gene ID: hg26524tg7292 | Hgene | Tgene | Gene symbol | LATS2 | TNFSF4 | Gene ID | 26524 | 7292 |
Gene name | large tumor suppressor kinase 2 | TNF superfamily member 4 | |
Synonyms | KPM | CD134L|CD252|GP34|OX-40L|OX4OL|TNLG2B|TXGP1 | |
Cytomap | ('LATS2')('TNFSF4') 13q12.11 | 1q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serine/threonine-protein kinase LATS2LATS (large tumor suppressor, Drosophila) homolog 2LATS, large tumor suppressor, homolog 2kinase phosphorylated during mitosis proteinlarge tumor suppressor homolog 2serine/threonine kinase KPMserine/threonine-pr | tumor necrosis factor ligand superfamily member 4CD134 ligandOX40 antigen ligandglycoprotein Gp34tax-transcriptionally activated glycoprotein 1 (34kD)tumor necrosis factor (ligand) superfamily member 4tumor necrosis factor ligand 2Btumor necrosis f | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000382592, ENST00000472754, ENST00000542899, | ||
Fusion gene scores | * DoF score | 4 X 6 X 3=72 | 8 X 8 X 2=128 |
# samples | 5 | 9 | |
** MAII score | log2(5/72*10)=-0.526068811667588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/128*10)=-0.508146903670325 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LATS2 [Title/Abstract] AND TNFSF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | LATS2(21620311)-TNFSF4(173345083), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LATS2 | GO:0000082 | G1/S transition of mitotic cell cycle | 12853976 |
Hgene | LATS2 | GO:0006468 | protein phosphorylation | 10871863 |
Hgene | LATS2 | GO:0009755 | hormone-mediated signaling pathway | 15131260 |
Hgene | LATS2 | GO:0035329 | hippo signaling | 20412773 |
Hgene | LATS2 | GO:0035556 | intracellular signal transduction | 10871863 |
Hgene | LATS2 | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity | 12853976 |
Tgene | TNFSF4 | GO:0032700 | negative regulation of interleukin-17 production | 18501882 |
Tgene | TNFSF4 | GO:0032729 | positive regulation of interferon-gamma production | 18501882 |
Tgene | TNFSF4 | GO:0032753 | positive regulation of interleukin-4 production | 18501882 |
Tgene | TNFSF4 | GO:0032755 | positive regulation of interleukin-6 production | 20844189 |
Tgene | TNFSF4 | GO:0050729 | positive regulation of inflammatory response | 20844189 |
Tgene | TNFSF4 | GO:0071222 | cellular response to lipopolysaccharide | 20844189 |
Tgene | TNFSF4 | GO:0071380 | cellular response to prostaglandin E stimulus | 19029446 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Fusion Gene ORF analysis for LATS2-TNFSF4 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for LATS2-TNFSF4 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for LATS2-TNFSF4 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:21620311/:173345083) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for LATS2-TNFSF4 |
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Fusion Gene PPI Analysis for LATS2-TNFSF4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for LATS2-TNFSF4 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for LATS2-TNFSF4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LATS2 | C0004114 | Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0205768 | Subependymal Giant Cell Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0280783 | Juvenile Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0280785 | Diffuse Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0334579 | Anaplastic astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0334580 | Protoplasmic astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0334581 | Gemistocytic astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0334582 | Fibrillary Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0334583 | Pilocytic Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0338070 | Childhood Cerebral Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0547065 | Mixed oligoastrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0750935 | Cerebral Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C0750936 | Intracranial Astrocytoma | 1 | CTD_human |
Hgene | LATS2 | C1704230 | Grade I Astrocytoma | 1 | CTD_human |
Tgene | C0024141 | Lupus Erythematosus, Systemic | 8 | CTD_human;ORPHANET | |
Tgene | C0242380 | Libman-Sacks Disease | 2 | CTD_human | |
Tgene | C0027404 | Narcolepsy | 1 | ORPHANET | |
Tgene | C0751362 | Narcolepsy-Cataplexy Syndrome | 1 | ORPHANET |