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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AATF-TADA2A (FusionGDB2 ID:HG26574TG6871)

Fusion Gene Summary for AATF-TADA2A

check button Fusion gene summary
Fusion gene informationFusion gene name: AATF-TADA2A
Fusion gene ID: hg26574tg6871
HgeneTgene
Gene symbol

AATF

TADA2A

Gene ID

26574

6871

Gene nameapoptosis antagonizing transcription factortranscriptional adaptor 2A
SynonymsBFR2|CHE-1|CHE1|DEDADA2|ADA2A|KL04P|TADA2L|hADA2
Cytomap('AATF')('TADA2A')

17q12

17q12

Type of geneprotein-codingprotein-coding
Descriptionprotein AATFrb-binding protein Che-1transcriptional adapter 2-alphaADA2-like proteintranscriptional adaptor 2 alpha
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000225402, ENST00000590321, 
Fusion gene scores* DoF score16 X 11 X 7=123210 X 8 X 5=400
# samples 1711
** MAII scorelog2(17/1232*10)=-2.8573956045572
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/400*10)=-1.86249647625006
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AATF [Title/Abstract] AND TADA2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAATF(35311207)-TADA2A(35834661), # samples:1
Anticipated loss of major functional domain due to fusion event.AATF-TADA2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AATF-TADA2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AATF-TADA2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AATF-TADA2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAATF

GO:0032929

negative regulation of superoxide anion generation

15207272

HgeneAATF

GO:0045944

positive regulation of transcription by RNA polymerase II

18049476

HgeneAATF

GO:2000378

negative regulation of reactive oxygen species metabolic process

15207272

TgeneTADA2A

GO:0043966

histone H3 acetylation

9674425


check buttonFusion gene breakpoints across AATF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TADA2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AQ-A04H-01BAATFchr17

35311207

+TADA2Achr17

35834661

+


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Fusion Gene ORF analysis for AATF-TADA2A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000225402ENST00000225396AATFchr17

35311207

+TADA2Achr17

35834661

+
5CDS-intronENST00000225402ENST00000417170AATFchr17

35311207

+TADA2Achr17

35834661

+
5CDS-intronENST00000225402ENST00000586023AATFchr17

35311207

+TADA2Achr17

35834661

+
5CDS-intronENST00000225402ENST00000591992AATFchr17

35311207

+TADA2Achr17

35834661

+
In-frameENST00000225402ENST00000394395AATFchr17

35311207

+TADA2Achr17

35834661

+
intron-3CDSENST00000590321ENST00000394395AATFchr17

35311207

+TADA2Achr17

35834661

+
intron-intronENST00000590321ENST00000225396AATFchr17

35311207

+TADA2Achr17

35834661

+
intron-intronENST00000590321ENST00000417170AATFchr17

35311207

+TADA2Achr17

35834661

+
intron-intronENST00000590321ENST00000586023AATFchr17

35311207

+TADA2Achr17

35834661

+
intron-intronENST00000590321ENST00000591992AATFchr17

35311207

+TADA2Achr17

35834661

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000225402AATFchr1735311207+ENST00000394395TADA2Achr1735834661+409110831071342411

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000225402ENST00000394395AATFchr1735311207+TADA2Achr1735834661+0.0005745870.9994254

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Fusion Genomic Features for AATF-TADA2A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AATFchr1735311207+TADA2Achr1735834660+3.33E-060.99999666
AATFchr1735311207+TADA2Achr1735834660+3.33E-060.99999666

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AATF-TADA2A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:35311207/chr17:35834661)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAATFchr17:35311207chr17:35834661ENST00000225402+41296_195277561.0Compositional biasNote=Glu-rich
TgeneTADA2Achr17:35311207chr17:35834661ENST0000041717001117_450306.0Compositional biasNote=Cys-rich
TgeneTADA2Achr17:35311207chr17:35834661ENST0000058602301117_450306.0Compositional biasNote=Cys-rich
TgeneTADA2Achr17:35311207chr17:35834661ENST000002253961316426_435357444.0DNA bindingOntology_term=ECO:0000250
TgeneTADA2Achr17:35311207chr17:35834661ENST000003943951316426_435357444.0DNA bindingOntology_term=ECO:0000250
TgeneTADA2Achr17:35311207chr17:35834661ENST00000417170011426_4350306.0DNA bindingOntology_term=ECO:0000250
TgeneTADA2Achr17:35311207chr17:35834661ENST00000586023011426_4350306.0DNA bindingOntology_term=ECO:0000250
TgeneTADA2Achr17:35311207chr17:35834661ENST000002253961316356_443357444.0DomainSWIRM
TgeneTADA2Achr17:35311207chr17:35834661ENST000003943951316356_443357444.0DomainSWIRM
TgeneTADA2Achr17:35311207chr17:35834661ENST00000417170011356_4430306.0DomainSWIRM
TgeneTADA2Achr17:35311207chr17:35834661ENST0000041717001170_1220306.0DomainSANT
TgeneTADA2Achr17:35311207chr17:35834661ENST00000586023011356_4430306.0DomainSWIRM
TgeneTADA2Achr17:35311207chr17:35834661ENST0000058602301170_1220306.0DomainSANT

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAATFchr17:35311207chr17:35834661ENST00000225402+412273_315277561.0RegionNote=POLR2J binding
HgeneAATFchr17:35311207chr17:35834661ENST00000225402+412316_372277561.0RegionNote=RB1 binding
HgeneAATFchr17:35311207chr17:35834661ENST00000225402+412373_472277561.0RegionNote=RB1 and SP1 binding
TgeneTADA2Achr17:35311207chr17:35834661ENST00000225396131617_45357444.0Compositional biasNote=Cys-rich
TgeneTADA2Achr17:35311207chr17:35834661ENST00000394395131617_45357444.0Compositional biasNote=Cys-rich
TgeneTADA2Achr17:35311207chr17:35834661ENST00000225396131670_122357444.0DomainSANT
TgeneTADA2Achr17:35311207chr17:35834661ENST00000394395131670_122357444.0DomainSANT


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Fusion Gene Sequence for AATF-TADA2A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>135_135_1_AATF-TADA2A_AATF_chr17_35311207_ENST00000225402_TADA2A_chr17_35834661_ENST00000394395_length(transcript)=4091nt_BP=1083nt
AATCCCTTCAACCTTCTGCGCGCTTCCGCCTTCATGCTAGCAACGCCCGCAGTGACGCGCAGGCCCCGCCCCCTCCCGCGCGCCTCCCGG
AAGTGGCCGGTCCAGAGCTGTGGGGTGGCCTCCGCGCGGTCTCTGGCGGAGTCGGGGAATCGGATCAAGGCGAGAGGATCCGGCAGGGAA
GGAGCTTCGGGGCCGGGGGTTGGGCCGCACATTTACGTGCGCGAAGCGGAGTGGACCGGGAGCTGGTGACGATGGCGGGGCCGCAGCCCC
TGGCGCTGCAACTGGAACAGTTGTTGAACCCGCGACCAAGCGAGGCGGACCCTGAAGCGGACCCCGAGGAAGCCACTGCTGCCAGGGTGA
TTGACAGGTTTGATGAAGGGGAAGATGGGGAAGGTGATTTCCTAGTAGTGGGTAGCATTAGAAAACTGGCATCAGCCTCCCTCTTGGACA
CGGACAAAAGGTATTGCGGCAAAACCACCTCTAGAAAAGCATGGAATGAAGACCATTGGGAGCAGACTCTGCCAGGATCGTCTGATGAGG
AAATATCTGATGAGGAAGGGTCTGGAGATGAAGATTCAGAGGGACTGGGTCTGGAGGAATATGATGAGGACGACCTGGGTGCTGCTGAGG
AACAGGAGTGTGGTGATCACAGGGAGAGCAAGAAGAGCAGAAGCCACTCTGCAAAAACACCGGGCTTCAGTGTCCAGAGTATCAGTGACT
TTGAGAAATTTACCAAGGGAATGGATGACCTTGGGAGCAGTGAGGAGGAGGAAGACGAAGAGAGTGGCATGGAAGAAGGGGATGACGCGG
AAGACTCCCAAGGCGAGAGTGAGGAAGACAGGGCTGGAGATAGAAACAGTGAGGATGATGGTGTGGTGATGACCTTCTCTAGTGTCAAAG
TTTCTGAGGAAGTGGAGAAAGGAAGAGCCGTGAAGAACCAGATAGCACTGTGGGACCAGCTCTTGGAAGGAAGGATCAAACTACAAAAAG
CTCTGTTGACCACCAACCAGCTTCCTCAACCAGATGTTTTCCCATTGTTCAAGGACAAAGGTGGCCCAGAATTTTCCAGTGCCCTGAAAA
ATAGTAGACGGAGTGCACCACCCTTGAACCTCACTGGCCTCCCTGGCACAGAGAAGCTGAATGAAAAAGAAAAGGAGCTCTGTCAGATGG
TGAGGTTGGTCCCTGGAGCCTATTTAGAATACAAATCTGCTCTATTGAACGAATGTAACAAGCAAGGAGGCTTAAGACTGGCGCAGGCAA
GAGCACTCATCAAGATAGATGTGAACAAAACCCGGAAAATCTATGATTTCCTCATCAGAGAAGGATACATCACTAAAGGCTAAGGCTCCA
AGAGCTTGGGATCAGAAGTCAGAAGTTTGGAATGTGGTGGGTCAAAGGACAATATGGGTGGGCATTCTGGAGAGTTGTTTTTCAGCTGAA
TTCTCATGGTGAAAACAGGGGAAAGGACAAAGGAAACCTTAAGTTGTATTGTCTACTTTCTTCTCCATCCTGCTTTAAAACACTCCTGTT
GTTGGTATTATGCTGCAGAGTTGTGTGCTACATAAGCTATTATTAAATGTGAGTGGGCATTCATTCCTAACACCTCTTGTAACTAAAAGA
ACCATAGTACCTCACATCACAGTGCTGGTAGAAATGGAACTAAACCACAGTCTGTAATCCCAGGAGTCCAGCTCAGATCCTTATATTGCG
AGGTAAGTTTGCTGATTATCTGTCTTGCCTTCAAACACTGCAGACAGATTTAAAATAAAGAGAAAGGTTTTAGAGCATAAGAAAGCTCTC
GTTGAAGGATTTTTTAAGCTGACAACTTTTTTTTTTTTTTTTTGAGACAGAGTTTGCTCTTGTCCTCCAGGCTGGAGTGTGATGGCAAGA
TCTCAGCTCACTACAACCTCTGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAATAGCTGGGACTACAGGTGTCCACCACC
ACACCTGGCTAATTTTGTATTTTTAGTAGAGACAGGGTTTTGTCATGTTGGCCAGGCTGGTCACAAACTCCTGACCTCAGGTGATCTGCC
CGCCTCAGCCTCCCAAAGTACTAGGATTACAGGCGTGAGCCATCGCGCCCGGCCTAAGCTGACAACTTTTATGAGTAAAGGGGAAGAAAA
TATCCTTATGATGGTCTTATCCCAAACTGCATCTTTAACTTCGGCCGGGCAAGGTGGCTCACCTGTAATCCCAGCACTTTGGGAGGCTAA
GGTGGGCGGATCACGAAGTCAGGAGTTCAAGACCAGCCTGACCAACATGGTGAAACAGTCTCTACTAAAAATACAAAAATTAGCTGAGTG
TGGTGGCACACGCCTGTAATCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATTGCTTGAACACAGGAGGCAGAGGTTGCAGCGAGCTGAG
ATCACGCCACTGTGCTCCAGCCTGGGCAACAAAGTGAGACTCTGTCTCAAAAAAAAAAAAACAAAAAAAAACCTTTAATGTCTGGCTTTG
TACTTTGCAGTCTGCCTGTCTAATCTGCAGTAGTCTTTTGAGGAGGTGGCACCGGATATAACATGTCTCTGTTATTTTTAGAATTAATTA
AAATGTTTTGCTATTTAATTTGTGGGTGTGTCAAATATTCTGGTAACTGAAACACACTTAAGGTGTTGGATGCCTGCCCCATCACGCTGC
ACTGTCTGCTGTCACATGTGTCCTGAACTCACCCTGTTTTTGCCCTGGGTTTCCCAGGATACCAAGCCCCTGAGGATGGAGATGATGCAA
CAAACCTCAGCTTTGCTTGGATTGTGACTTGAACCCTATTTCTCAATGGTGAAAGGCTAGCCTGCAATAAAAGCTGCTTTTAAAACAGAA
GTAAAGCAGCTTTATATATGGGACTCACTAGATATGAGGGTAAGTAGCCCCACCACATGTAAAACTTGGTCCTCAAACGTTTCTGCAGAA
TAAGAAGCCAAACTTATGGTTATCTTGTTTCTGTTAGAAACAAAGTTGTATATAGAAATAACTTCGTCAGAATCGACACAAATCACATCG
AATAGTTGACTGTTTAATTCCTTCTACATTCAAATATCTAATTAAAATACTGTGTGCTTTGTTGGAAGCATCTGCTCAAACTTTTGACTG
TTGTAAATATGCATGCAGCTGGGAAGGGATTCATCTAAGGGATAAGAAATGAAAAAGACACTCTAAGGACCTGAGGGAATTCAAATAGAG
GACTTCGATTTTTTAAAAAGAATGACGTGGAAATGACCTGTTTTCCTTGTAAAATCATATCTCGTAGAAAACATTTTACCACTACCATCA
CCCCTAGTTGGTTGTGAAGTGATTGCCTCTTATCCCTGAAAGGAAACTCCTGTTCTGAAAAGTTGGGATGCATTAGCCATCAGTGTTAGG
TGACGTCTGTTGTAGTCTGAAGAGTCCTTAACCTTGATTAAGGAAGGCTTCCTGGGAGAGGTGGGCTTTTGGGGCAATTATATGATAGAG
AAGAGAGAGAAAAATGGCAGATGGAAGTGGGAGACAATTCCACACACAGGGGGTGGAGAATGATGTGGAGGCAGCAGTGGGTGTAAGGAC
AATGGTGCCAAGAGATTTATTTGGCTAGAACACAAGGGGCAGCTGGGTAGTTAGGAGTGGGAGGATGGTAGGACAGTCTGACAGAAACCT
TGGAAACAGTTGAACTCTGAAAAGCTGATGGCAAATCAGATTTCATGAGGAAAATGGCATGGTTGAAAATAGTAATAGAAAAATAAGACT
GAAGTTTTAAATGACTGGATTTTTGAAAGTAGGATTATTATTTCTTTGGTATACCGAACTTTGCAAAGATACGTAGCATTGCATCCTTCC
TCTTTGCTTCTAGACAGGGTTGGCCATAAACCAACTACACTGATAGAGGTCTCTCCAGATTGTCTCAGAAGAGAGAGTTTACCCTGAAAC
TTAATGACATGAATAAAACCTGTTTACTGAAATTTTTATTGCAATTTAACGTTAAAAGTTTCTGCTGGAGTTTTATGCATATTTTTCTCT

>135_135_1_AATF-TADA2A_AATF_chr17_35311207_ENST00000225402_TADA2A_chr17_35834661_ENST00000394395_length(amino acids)=411AA_BP=1
MWGGLRAVSGGVGESDQGERIRQGRSFGAGGWAAHLRARSGVDRELVTMAGPQPLALQLEQLLNPRPSEADPEADPEEATAARVIDRFDE
GEDGEGDFLVVGSIRKLASASLLDTDKRYCGKTTSRKAWNEDHWEQTLPGSSDEEISDEEGSGDEDSEGLGLEEYDEDDLGAAEEQECGD
HRESKKSRSHSAKTPGFSVQSISDFEKFTKGMDDLGSSEEEEDEESGMEEGDDAEDSQGESEEDRAGDRNSEDDGVVMTFSSVKVSEEVE
KGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPLFKDKGGPEFSSALKNSRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPG

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Fusion Gene PPI Analysis for AATF-TADA2A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AATF-TADA2A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AATF-TADA2A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource