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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMFR-ITGAM (FusionGDB2 ID:HG267TG3684)

Fusion Gene Summary for AMFR-ITGAM

check button Fusion gene summary
Fusion gene informationFusion gene name: AMFR-ITGAM
Fusion gene ID: hg267tg3684
HgeneTgene
Gene symbol

AMFR

ITGAM

Gene ID

267

3684

Gene nameautocrine motility factor receptorintegrin subunit alpha M
SynonymsGP78|RNF45CD11B|CR3A|MAC-1|MAC1A|MO1A|SLEB6
Cytomap('AMFR')('ITGAM')

16q13

16p11.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase AMFRRING finger protein 45RING-type E3 ubiquitin transferase AMFRintegrin alpha-MCD11 antigen-like family member BCR-3 alpha chainantigen CD11b (p170)cell surface glycoprotein MAC-1 subunit alphacomplement component 3 receptor 3 subunitintegrin, alpha M (complement component 3 receptor 3 subunit)leukocyte adhesi
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000290649, ENST00000564283, 
Fusion gene scores* DoF score7 X 5 X 5=1754 X 5 X 4=80
# samples 85
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMFR [Title/Abstract] AND ITGAM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMFR(56419831)-ITGAM(31332562), # samples:3
Anticipated loss of major functional domain due to fusion event.AMFR-ITGAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ITGAM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ITGAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ITGAM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMFR

GO:0000209

protein polyubiquitination

17310145|19103148

HgeneAMFR

GO:0030433

ubiquitin-dependent ERAD pathway

11724934|17872946

HgeneAMFR

GO:0051865

protein autoubiquitination

24810856

HgeneAMFR

GO:0070936

protein K48-linked ubiquitination

12847084|24424410


check buttonFusion gene breakpoints across AMFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ITGAM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A27W-01AAMFRchr16

56419830

-ITGAMchr16

31332561

+
ChimerDB4BRCATCGA-D8-A27W-01AAMFRchr16

56419831

-ITGAMchr16

31332562

+
ChimerDB4BRCATCGA-D8-A27WAMFRchr16

56419830

-ITGAMchr16

31332561

+


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Fusion Gene ORF analysis for AMFR-ITGAM

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000290649ENST00000287497AMFRchr16

56419831

-ITGAMchr16

31332562

+
In-frameENST00000290649ENST00000287497AMFRchr16

56419830

-ITGAMchr16

31332561

+
In-frameENST00000290649ENST00000544665AMFRchr16

56419831

-ITGAMchr16

31332562

+
In-frameENST00000290649ENST00000544665AMFRchr16

56419830

-ITGAMchr16

31332561

+
intron-3CDSENST00000564283ENST00000287497AMFRchr16

56419831

-ITGAMchr16

31332562

+
intron-3CDSENST00000564283ENST00000287497AMFRchr16

56419830

-ITGAMchr16

31332561

+
intron-3CDSENST00000564283ENST00000544665AMFRchr16

56419831

-ITGAMchr16

31332562

+
intron-3CDSENST00000564283ENST00000544665AMFRchr16

56419830

-ITGAMchr16

31332561

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000290649AMFRchr1656419831-ENST00000287497ITGAMchr1631332562+3404159121133421043
ENST00000290649AMFRchr1656419831-ENST00000544665ITGAMchr1631332562+4528159121133421043
ENST00000290649AMFRchr1656419830-ENST00000287497ITGAMchr1631332561+3404159121133421043
ENST00000290649AMFRchr1656419830-ENST00000544665ITGAMchr1631332561+4528159121133421043

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290649ENST00000287497AMFRchr1656419831-ITGAMchr1631332562+0.0026156970.99738425
ENST00000290649ENST00000544665AMFRchr1656419831-ITGAMchr1631332562+0.001048530.99895144
ENST00000290649ENST00000287497AMFRchr1656419830-ITGAMchr1631332561+0.0026156970.99738425
ENST00000290649ENST00000544665AMFRchr1656419830-ITGAMchr1631332561+0.001048530.99895144

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Fusion Genomic Features for AMFR-ITGAM


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AMFRchr1656419830-ITGAMchr1631332561+1.84E-091
AMFRchr1656419830-ITGAMchr1631332561+1.84E-091
AMFRchr1656419830-ITGAMchr1631332561+1.84E-091
AMFRchr1656419830-ITGAMchr1631332561+1.84E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for AMFR-ITGAM


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:56419831/chr16:31332562)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014122_142460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014145_165460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014186_206460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014215_235460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014276_296460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014429_449460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-101482_102460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014122_142460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014145_165460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014186_206460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014215_235460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014276_296460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014429_449460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-101482_102460644.0TransmembraneHelical
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014341_379460644.0Zinc fingerRING-type
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014341_379460644.0Zinc fingerRING-type
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330592_6005691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330592_6005701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330592_6005691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330592_6005701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST0000028749713301131_11355691153.0MotifNote=GFFKR motif
TgeneITGAMchr16:56419830chr16:31332561ENST0000054466513301131_11355701154.0MotifNote=GFFKR motif
TgeneITGAMchr16:56419831chr16:31332562ENST0000028749713301131_11355691153.0MotifNote=GFFKR motif
TgeneITGAMchr16:56419831chr16:31332562ENST0000054466513301131_11355701154.0MotifNote=GFFKR motif
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330569_6295691153.0RepeatFG-GAP 7
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330569_6295701154.0RepeatFG-GAP 7
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330569_6295691153.0RepeatFG-GAP 7
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330569_6295701154.0RepeatFG-GAP 7
TgeneITGAMchr16:56419830chr16:31332561ENST0000028749713301129_11525691153.0Topological domainCytoplasmic
TgeneITGAMchr16:56419830chr16:31332561ENST0000054466513301129_11525701154.0Topological domainCytoplasmic
TgeneITGAMchr16:56419831chr16:31332562ENST0000028749713301129_11525691153.0Topological domainCytoplasmic
TgeneITGAMchr16:56419831chr16:31332562ENST0000054466513301129_11525701154.0Topological domainCytoplasmic
TgeneITGAMchr16:56419830chr16:31332561ENST0000028749713301105_11285691153.0TransmembraneHelical
TgeneITGAMchr16:56419830chr16:31332561ENST0000054466513301105_11285701154.0TransmembraneHelical
TgeneITGAMchr16:56419831chr16:31332562ENST0000028749713301105_11285691153.0TransmembraneHelical
TgeneITGAMchr16:56419831chr16:31332562ENST0000054466513301105_11285701154.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014456_498460644.0DomainCUE
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014456_498460644.0DomainCUE
HgeneAMFRchr16:56419830chr16:31332561ENST00000290649-1014622_640460644.0RegionVCP/p97-interacting motif (VIM)
HgeneAMFRchr16:56419831chr16:31332562ENST00000290649-1014622_640460644.0RegionVCP/p97-interacting motif (VIM)
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330465_4735691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330529_5375691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330465_4735701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330529_5375701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330465_4735691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330529_5375691153.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330465_4735701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330529_5375701154.0Calcium bindingOntology_term=ECO:0000255
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330150_3285691153.0DomainVWFA
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330150_3285701154.0DomainVWFA
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330150_3285691153.0DomainVWFA
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330150_3285701154.0DomainVWFA
TgeneITGAMchr16:56419830chr16:31332561ENST00000287497133018_755691153.0RepeatFG-GAP 1
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330339_3905691153.0RepeatFG-GAP 3
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330391_4425691153.0RepeatFG-GAP 4
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330443_5035691153.0RepeatFG-GAP 5
TgeneITGAMchr16:56419830chr16:31332561ENST000002874971330506_5645691153.0RepeatFG-GAP 6
TgeneITGAMchr16:56419830chr16:31332561ENST00000287497133076_1355691153.0RepeatFG-GAP 2
TgeneITGAMchr16:56419830chr16:31332561ENST00000544665133018_755701154.0RepeatFG-GAP 1
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330339_3905701154.0RepeatFG-GAP 3
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330391_4425701154.0RepeatFG-GAP 4
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330443_5035701154.0RepeatFG-GAP 5
TgeneITGAMchr16:56419830chr16:31332561ENST000005446651330506_5645701154.0RepeatFG-GAP 6
TgeneITGAMchr16:56419830chr16:31332561ENST00000544665133076_1355701154.0RepeatFG-GAP 2
TgeneITGAMchr16:56419831chr16:31332562ENST00000287497133018_755691153.0RepeatFG-GAP 1
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330339_3905691153.0RepeatFG-GAP 3
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330391_4425691153.0RepeatFG-GAP 4
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330443_5035691153.0RepeatFG-GAP 5
TgeneITGAMchr16:56419831chr16:31332562ENST000002874971330506_5645691153.0RepeatFG-GAP 6
TgeneITGAMchr16:56419831chr16:31332562ENST00000287497133076_1355691153.0RepeatFG-GAP 2
TgeneITGAMchr16:56419831chr16:31332562ENST00000544665133018_755701154.0RepeatFG-GAP 1
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330339_3905701154.0RepeatFG-GAP 3
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330391_4425701154.0RepeatFG-GAP 4
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330443_5035701154.0RepeatFG-GAP 5
TgeneITGAMchr16:56419831chr16:31332562ENST000005446651330506_5645701154.0RepeatFG-GAP 6
TgeneITGAMchr16:56419831chr16:31332562ENST00000544665133076_1355701154.0RepeatFG-GAP 2
TgeneITGAMchr16:56419830chr16:31332561ENST00000287497133017_11045691153.0Topological domainExtracellular
TgeneITGAMchr16:56419830chr16:31332561ENST00000544665133017_11045701154.0Topological domainExtracellular
TgeneITGAMchr16:56419831chr16:31332562ENST00000287497133017_11045691153.0Topological domainExtracellular
TgeneITGAMchr16:56419831chr16:31332562ENST00000544665133017_11045701154.0Topological domainExtracellular


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Fusion Gene Sequence for AMFR-ITGAM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4216_4216_1_AMFR-ITGAM_AMFR_chr16_56419830_ENST00000290649_ITGAM_chr16_31332561_ENST00000287497_length(transcript)=3404nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGCGGATAGCAGGCTCCAAGCTCTCTCCCAG
GCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGT
GCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAA
TGATCAGGTGGTGAAAGGCAAGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAGAAGGACA
GATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACG
CAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCAT
TGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACT
CTTCACAGCCTTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCATGAGCCT
GGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGACTCCTACAGGACACAGGTCAC
CTTCTTCTTCCCGCTTGACCTGTCCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCTGTGAGTC
TGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTT
TAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAG
AACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCT
CAACTTCACGGCCTCAGAGAATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCATCAGCCT
GGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCA
CACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAG
AATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGAC
CTCGCATAACCACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGGCGTTTGT
GAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCT
CCTGGCCCTCATCACCGCCGCGCTGTACAAGCTCGGCTTCTTCAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCCCGGGGGC
CGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCTCGGTGGCCAGCAGGACTCTGCCCAGACCACACGT

>4216_4216_1_AMFR-ITGAM_AMFR_chr16_56419830_ENST00000290649_ITGAM_chr16_31332561_ENST00000287497_length(amino acids)=1043AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG
EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVG
TPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYR
KVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLEL
PVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSD
FLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEP
FEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ

--------------------------------------------------------------
>4216_4216_2_AMFR-ITGAM_AMFR_chr16_56419830_ENST00000290649_ITGAM_chr16_31332561_ENST00000544665_length(transcript)=4528nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGCGGATAGCAGGCTCCAAGCTCTCTCCCAG
GCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGT
GCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAA
TGATCAGGTGGTGAAAGGCAAGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAGAAGGACA
GATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACG
CAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCAT
TGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACT
CTTCACAGCCTTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCATGAGCCT
GGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGACTCCTACAGGACACAGGTCAC
CTTCTTCTTCCCGCTTGACCTGTCCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCTGTGAGTC
TGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTT
TAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAG
AACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCT
CAACTTCACGGCCTCAGAGAATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCATCAGCCT
GGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCA
CACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAG
AATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGAC
CTCGCATAACCACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGGCGTTTGT
GAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCT
CCTGGCCCTCATCACCGCCGCGCTGTACAAGCTCGGCTTCTTCAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCCCGGGGGC
CGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCTCGGTGGCCAGCAGGACTCTGCCCAGACCACACGTAGCCCCCAGGCTGCTG
GACACGTCGGACAGCGAAGTATCCCCGACAGGACGGGCTTGGGCTTCCATTTGTGTGTGTGCAAGTGTGTATGTGCGTGTGTGCAAGTGT
CTGTGTGCAAGTGTGTGCACATGTGTGCGTGTGCGTGCATGTGCACTTGCACGCCCATGTGTGAGTGTGTGCAAGTATGTGAGTGTGTCC
AAGTGTGTGTGCGTGTGTCCATGTGTGTGCAAGTGTGTGCATGTGTGCGAGTGTGTGCATGTGTGTGCTCAGGGGCGTGTGGCTCACGTG
TGTGACTCAGATGTCTCTGGCGTGTGGGTAGGTGACGGCAGCGTAGCCTCTCCGGCAGAAGGGAACTGCCTGGGCTCCCTTGTGCGTGGG
TGAAGCCGCTGCTGGGTTTTCCTCCGGGAGAGGGGACGGTCAATCCTGTGGGTGAAGACAGAGGGAAACACAGCAGCTTCTCTCCACTGA
AAGAAGTGGGACTTCCCGTCGCCTGCGAGCCTGCGGCCTGCTGGAGCCTGCGCAGCTTGGATGGAGACTCCATGAGAAGCCGTGGGTGGA
ACCAGGAACCTCCTCCACACCAGCGCTGATGCCCAATAAAGATGCCCACTGAGGAATGATGAAGCTTCCTTTCTGGATTCATTTATTATT
TCAATGTGACTTTAATTTTTTGGATGGATAAGCTTGTCTATGGTACAAAAATCACAAGGCATTCAAGTGTACAGTGAAAAGTCTCCCTTT
CCAGATATTCAAGTCACCTCCTTAAAGGTAGTCAAGATTGTGTTTTGAGGTTTCCTTCAGACAGATTCCAGGCGATGTGCAAGTGTATGC
ACGTGTGCACACACACCACACATACACACACACAAGCTTTTTTACACAAATGGTAGCATACTTTATATTGGTCTGTATCTTGCTTTTTTT
CACCAATATTTCTCAGACATCGGTTCATATTAAGACATAAATTACTTTTTCATTCTTTTATACCGCTGCATAGTATTCCATTGTGTGAGT
GTACCATAATGTATTTAACCAGTCTTCTTTTGATATACTATTTTCATTCTCTTGTTATTGCATCAATGCTGAGTTAATAAATCAAATATA
TGTCATTTTTGCATATATGTAAGGATAA

>4216_4216_2_AMFR-ITGAM_AMFR_chr16_56419830_ENST00000290649_ITGAM_chr16_31332561_ENST00000544665_length(amino acids)=1043AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG
EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVG
TPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYR
KVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLEL
PVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSD
FLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEP
FEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ

--------------------------------------------------------------
>4216_4216_3_AMFR-ITGAM_AMFR_chr16_56419831_ENST00000290649_ITGAM_chr16_31332562_ENST00000287497_length(transcript)=3404nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGCGGATAGCAGGCTCCAAGCTCTCTCCCAG
GCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGT
GCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAA
TGATCAGGTGGTGAAAGGCAAGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAGAAGGACA
GATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACG
CAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCAT
TGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACT
CTTCACAGCCTTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCATGAGCCT
GGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGACTCCTACAGGACACAGGTCAC
CTTCTTCTTCCCGCTTGACCTGTCCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCTGTGAGTC
TGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTT
TAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAG
AACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCT
CAACTTCACGGCCTCAGAGAATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCATCAGCCT
GGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCA
CACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAG
AATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGAC
CTCGCATAACCACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGGCGTTTGT
GAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCT
CCTGGCCCTCATCACCGCCGCGCTGTACAAGCTCGGCTTCTTCAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCCCGGGGGC
CGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCTCGGTGGCCAGCAGGACTCTGCCCAGACCACACGT

>4216_4216_3_AMFR-ITGAM_AMFR_chr16_56419831_ENST00000290649_ITGAM_chr16_31332562_ENST00000287497_length(amino acids)=1043AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG
EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVG
TPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYR
KVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLEL
PVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSD
FLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEP
FEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ

--------------------------------------------------------------
>4216_4216_4_AMFR-ITGAM_AMFR_chr16_56419831_ENST00000290649_ITGAM_chr16_31332562_ENST00000544665_length(transcript)=4528nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGCGGATAGCAGGCTCCAAGCTCTCTCCCAG
GCTCCAGTATTTTGGTCAGTCACTGAGTGGGGGCCAGGACCTCACAATGGATGGACTGGTAGACCTGACTGTAGGAGCCCAGGGGCACGT
GCTGCTGCTCAGGTCCCAGCCAGTACTGAGAGTCAAGGCAATCATGGAGTTCAATCCCAGGGAAGTGGCAAGGAATGTATTTGAGTGTAA
TGATCAGGTGGTGAAAGGCAAGGAAGCCGGAGAGGTCAGAGTCTGCCTCCATGTCCAGAAGAGCACACGGGATCGGCTAAGAGAAGGACA
GATCCAGAGTGTTGTGACTTATGACCTGGCTCTGGACTCCGGCCGCCCACATTCCCGCGCCGTCTTCAATGAGACAAAGAACAGCACACG
CAGACAGACACAGGTCTTGGGGCTGACCCAGACTTGTGAGACCCTGAAACTACAGTTGCCGAATTGCATCGAGGACCCAGTGAGCCCCAT
TGTGCTGCGCCTGAACTTCTCTCTGGTGGGAACGCCATTGTCTGCTTTCGGGAACCTCCGGCCAGTGCTGGCGGAGGATGCTCAGAGACT
CTTCACAGCCTTGTTTCCCTTTGAGAAGAATTGTGGCAATGACAACATCTGCCAGGATGACCTCAGCATCACCTTCAGTTTCATGAGCCT
GGACTGCCTCGTGGTGGGTGGGCCCCGGGAGTTCAACGTGACAGTGACTGTGAGAAATGATGGTGAGGACTCCTACAGGACACAGGTCAC
CTTCTTCTTCCCGCTTGACCTGTCCTACCGGAAGGTGTCCACGCTCCAGAACCAGCGCTCACAGCGATCCTGGCGCCTGGCCTGTGAGTC
TGCCTCCTCCACCGAAGTGTCTGGGGCCTTGAAGAGCACCAGCTGCAGCATAAACCACCCCATCTTCCCGGAAAACTCAGAGGTCACCTT
TAATATCACGTTTGATGTAGACTCTAAGGCTTCCCTTGGAAACAAACTGCTCCTCAAGGCCAATGTGACCAGTGAGAACAACATGCCCAG
AACCAACAAAACCGAATTCCAACTGGAGCTGCCGGTGAAATATGCTGTCTACATGGTGGTCACCAGCCATGGGGTCTCCACTAAATATCT
CAACTTCACGGCCTCAGAGAATACCAGTCGGGTCATGCAGCATCAATATCAGGTCAGCAACCTGGGGCAGAGGAGCCTCCCCATCAGCCT
GGTGTTCTTGGTGCCCGTCCGGCTGAACCAGACTGTCATATGGGACCGCCCCCAGGTCACCTTCTCCGAGAACCTCTCGAGTACGTGCCA
CACCAAGGAGCGCTTGCCCTCTCACTCCGACTTTCTGGCTGAGCTTCGGAAGGCCCCCGTGGTGAACTGCTCCATCGCTGTCTGCCAGAG
AATCCAGTGTGACATCCCGTTCTTTGGCATCCAGGAAGAATTCAATGCTACCCTCAAAGGCAACCTCTCGTTTGACTGGTACATCAAGAC
CTCGCATAACCACCTCCTGATCGTGAGCACAGCTGAGATCTTGTTTAACGATTCCGTGTTCACCCTGCTGCCGGGACAGGGGGCGTTTGT
GAGGTCCCAGACGGAGACCAAAGTGGAGCCGTTCGAGGTCCCCAACCCCCTGCCGCTCATCGTGGGCAGCTCTGTCGGGGGACTGCTGCT
CCTGGCCCTCATCACCGCCGCGCTGTACAAGCTCGGCTTCTTCAAGCGGCAATACAAGGACATGATGAGTGAAGGGGGTCCCCCGGGGGC
CGAACCCCAGTAGCGGCTCCTTCCCGACAGAGCTGCCTCTCGGTGGCCAGCAGGACTCTGCCCAGACCACACGTAGCCCCCAGGCTGCTG
GACACGTCGGACAGCGAAGTATCCCCGACAGGACGGGCTTGGGCTTCCATTTGTGTGTGTGCAAGTGTGTATGTGCGTGTGTGCAAGTGT
CTGTGTGCAAGTGTGTGCACATGTGTGCGTGTGCGTGCATGTGCACTTGCACGCCCATGTGTGAGTGTGTGCAAGTATGTGAGTGTGTCC
AAGTGTGTGTGCGTGTGTCCATGTGTGTGCAAGTGTGTGCATGTGTGCGAGTGTGTGCATGTGTGTGCTCAGGGGCGTGTGGCTCACGTG
TGTGACTCAGATGTCTCTGGCGTGTGGGTAGGTGACGGCAGCGTAGCCTCTCCGGCAGAAGGGAACTGCCTGGGCTCCCTTGTGCGTGGG
TGAAGCCGCTGCTGGGTTTTCCTCCGGGAGAGGGGACGGTCAATCCTGTGGGTGAAGACAGAGGGAAACACAGCAGCTTCTCTCCACTGA
AAGAAGTGGGACTTCCCGTCGCCTGCGAGCCTGCGGCCTGCTGGAGCCTGCGCAGCTTGGATGGAGACTCCATGAGAAGCCGTGGGTGGA
ACCAGGAACCTCCTCCACACCAGCGCTGATGCCCAATAAAGATGCCCACTGAGGAATGATGAAGCTTCCTTTCTGGATTCATTTATTATT
TCAATGTGACTTTAATTTTTTGGATGGATAAGCTTGTCTATGGTACAAAAATCACAAGGCATTCAAGTGTACAGTGAAAAGTCTCCCTTT
CCAGATATTCAAGTCACCTCCTTAAAGGTAGTCAAGATTGTGTTTTGAGGTTTCCTTCAGACAGATTCCAGGCGATGTGCAAGTGTATGC
ACGTGTGCACACACACCACACATACACACACACAAGCTTTTTTACACAAATGGTAGCATACTTTATATTGGTCTGTATCTTGCTTTTTTT
CACCAATATTTCTCAGACATCGGTTCATATTAAGACATAAATTACTTTTTCATTCTTTTATACCGCTGCATAGTATTCCATTGTGTGAGT
GTACCATAATGTATTTAACCAGTCTTCTTTTGATATACTATTTTCATTCTCTTGTTATTGCATCAATGCTGAGTTAATAAATCAAATATA
TGTCATTTTTGCATATATGTAAGGATAA

>4216_4216_4_AMFR-ITGAM_AMFR_chr16_56419831_ENST00000290649_ITGAM_chr16_31332562_ENST00000544665_length(amino acids)=1043AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMRIAGSKLSPRLQYFGQSLSGGQDLTMDGLVDLTVGAQGHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAG
EVRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGLTQTCETLKLQLPNCIEDPVSPIVLRLNFSLVG
TPLSAFGNLRPVLAEDAQRLFTALFPFEKNCGNDNICQDDLSITFSFMSLDCLVVGGPREFNVTVTVRNDGEDSYRTQVTFFFPLDLSYR
KVSTLQNQRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLLLKANVTSENNMPRTNKTEFQLEL
PVKYAVYMVVTSHGVSTKYLNFTASENTSRVMQHQYQVSNLGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSENLSSTCHTKERLPSHSD
FLAELRKAPVVNCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSVFTLLPGQGAFVRSQTETKVEP
FEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFKRQYKDMMSEGGPPGAEPQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMFR-ITGAM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMFR-ITGAM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMFR-ITGAM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAMFRC0002395Alzheimer's Disease1CTD_human
HgeneAMFRC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneAMFRC0005695Bladder Neoplasm1CTD_human
HgeneAMFRC0011265Presenile dementia1CTD_human
HgeneAMFRC0235874Disease Exacerbation1CTD_human
HgeneAMFRC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneAMFRC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneAMFRC0546126Acute Confusional Senile Dementia1CTD_human
HgeneAMFRC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneAMFRC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0024141Lupus Erythematosus, Systemic5CTD_human;ORPHANET
TgeneC0242380Libman-Sacks Disease2CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0020456Hyperglycemia1CTD_human
TgeneC0020459Hyperinsulinism1CTD_human
TgeneC0020877Ileitis1CTD_human
TgeneC0021655Insulin Resistance1CTD_human
TgeneC0023487Acute Promyelocytic Leukemia1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0162820Dermatitis, Allergic Contact1CTD_human
TgeneC0752332Lupus Vasculitis, Central Nervous System1CTD_human
TgeneC0752334Lupus Meningoencephalitis1CTD_human
TgeneC0752335Neuropsychiatric Systemic Lupus Erythematosus1CTD_human
TgeneC0920563Insulin Sensitivity1CTD_human
TgeneC1257963Endogenous Hyperinsulinism1CTD_human
TgeneC1257964Exogenous Hyperinsulinism1CTD_human
TgeneC1257965Compensatory Hyperinsulinemia1CTD_human
TgeneC1855520Hyperglycemia, Postprandial1CTD_human