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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:AMFR-ST7L (FusionGDB2 ID:HG267TG54879)

Fusion Gene Summary for AMFR-ST7L

check button Fusion gene summary
Fusion gene informationFusion gene name: AMFR-ST7L
Fusion gene ID: hg267tg54879
HgeneTgene
Gene symbol

AMFR

ST7L

Gene ID

267

54879

Gene nameautocrine motility factor receptorsuppression of tumorigenicity 7 like
SynonymsGP78|RNF45FAM4B|ST7R|STLR
Cytomap('AMFR')('ST7L')

16q13

1p13.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase AMFRRING finger protein 45RING-type E3 ubiquitin transferase AMFRsuppressor of tumorigenicity 7 protein-likeST7-related proteintumor suppressor ST7 like
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000290649, ENST00000564283, 
Fusion gene scores* DoF score7 X 5 X 5=1758 X 10 X 3=240
# samples 810
** MAII scorelog2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/240*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: AMFR [Title/Abstract] AND ST7L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAMFR(56419831)-ST7L(113153625), # samples:1
Anticipated loss of major functional domain due to fusion event.AMFR-ST7L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ST7L seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ST7L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AMFR-ST7L seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAMFR

GO:0000209

protein polyubiquitination

17310145|19103148

HgeneAMFR

GO:0030433

ubiquitin-dependent ERAD pathway

11724934|17872946

HgeneAMFR

GO:0051865

protein autoubiquitination

24810856

HgeneAMFR

GO:0070936

protein K48-linked ubiquitination

12847084|24424410


check buttonFusion gene breakpoints across AMFR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ST7L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A66L-01AAMFRchr16

56419831

-ST7Lchr1

113153625

-


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Fusion Gene ORF analysis for AMFR-ST7L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000290649ENST00000343210AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000369666AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000369668AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000369669AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000463235AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000490067AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000538187AMFRchr16

56419831

-ST7Lchr1

113153625

-
5CDS-5UTRENST00000290649ENST00000543570AMFRchr16

56419831

-ST7Lchr1

113153625

-
In-frameENST00000290649ENST00000358039AMFRchr16

56419831

-ST7Lchr1

113153625

-
In-frameENST00000290649ENST00000360743AMFRchr16

56419831

-ST7Lchr1

113153625

-
In-frameENST00000290649ENST00000544629AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-3CDSENST00000564283ENST00000358039AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-3CDSENST00000564283ENST00000360743AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-3CDSENST00000564283ENST00000544629AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000343210AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000369666AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000369668AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000369669AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000463235AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000490067AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000538187AMFRchr16

56419831

-ST7Lchr1

113153625

-
intron-5UTRENST00000564283ENST00000543570AMFRchr16

56419831

-ST7Lchr1

113153625

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000290649AMFRchr1656419831-ENST00000360743ST7Lchr1113153625-543315912112937908
ENST00000290649AMFRchr1656419831-ENST00000358039ST7Lchr1113153625-552615912113030939
ENST00000290649AMFRchr1656419831-ENST00000544629ST7Lchr1113153625-309015912112835874

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000290649ENST00000360743AMFRchr1656419831-ST7Lchr1113153625-0.0011490560.99885094
ENST00000290649ENST00000358039AMFRchr1656419831-ST7Lchr1113153625-0.0008104550.99918956
ENST00000290649ENST00000544629AMFRchr1656419831-ST7Lchr1113153625-0.0050391950.9949608

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Fusion Genomic Features for AMFR-ST7L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for AMFR-ST7L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:56419831/chr1:113153625)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014122_142460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014145_165460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014186_206460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014215_235460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014276_296460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014429_449460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-101482_102460644.0TransmembraneHelical
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014341_379460644.0Zinc fingerRING-type
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966611480_10079539.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966911436_560393.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966911480_1000393.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000049006711580_10079559.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014456_498460644.0DomainCUE
HgeneAMFRchr16:56419831chr1:113153625ENST00000290649-1014622_640460644.0RegionVCP/p97-interacting motif (VIM)
TgeneST7Lchr16:56419831chr1:113153625ENST0000034321011436_5696556.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000034321011480_10096556.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000035803911536_5696576.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000035803911580_10096576.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036074311436_5696545.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036074311480_10096545.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966611436_5679539.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966811536_5696556.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000036966811580_10096556.0TransmembraneHelical
TgeneST7Lchr16:56419831chr1:113153625ENST0000049006711536_5679559.0TransmembraneHelical


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Fusion Gene Sequence for AMFR-ST7L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4219_4219_1_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000358039_length(transcript)=5526nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGATACACTTGGGTGACTGGTAAAGAGCCACTTACATACTATGACATGAACCTGTCAGCTCAGGACCATCAGACCTTTTTCAC
CTGTGACACAGATTTTTTACGTCCTTCAGACACAGTTATGCAGAAGGCTTGGAGGGAAAGAAATCCTCCAGCTCGAATCAAAGCAGCCTA
TCAAGCTTTAGAATTAAACAATGACTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTT
ATTTAAACAGGCACTCAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAG
GAGAGATACCAATGTACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAAT
GAGAGATTTGATGAAAGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCC
AGATGTTCAGGCAGTCCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAG
GACTGTTTCAGAAAAATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGC
TGTGGAATTTAATCCTCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAG
TGAAGCAATTGCCTATGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCAC
TTTTAGAATGATTCCATACCCGTTAGAGAAAGGACATCTATTTTACCCTTATCCCAGCTGCACAGAGACGGCTGATAGAGAGCTATTACC
TACCTTTCATCATGTTTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGAT
AGCCATTCTCACTCACCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTC
AGGCTTTGAGGAGAATACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACA
AATCACCAAATTTTTCTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCA
TTTTGCATATGAAAAAGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAAT
TGTCTTCCTTTTTTCTTCATTCAGCTTAGCCTTTCTGTTTGGCCAGGGCTACTTACAGGGGCTGTTGGGGTTGAAGTCAAGTCACCGCAT
TTTGGCTCCTTTGGTCAAAGAGAAAGAACTCTAATGTCCAGCTGCTCCATCGATATACTCATAGAATGGAAGTGAGCAAAGGAAAATTTT
AAGCCAGGATAGTTAACCGTTAGGGGGCCAGTGGGAGAATGCTTGCCTTGCATTTGCACATCCAGAATGACTAAAACATCTTAAGTAAAT
GAGGAATAGCCACCGAGATGCTCAGAGATAATATAAGCCATGAGTGGGAAGTGGGAAAATGAGTTTGTCAACGCCCTCTCTTTTCTATCC
CTTTACCTTTGAGGTCAGGGACAGGGCATATTACTGACACCCCACTGGCTATTGCCCTATACCTGCCAATCACCCAAAGAAAATAATAGC
TTCTGAGAAAGCTCAATTCACTGTAGCAACTGTGATATATTTACCCTAATAAAGCCACCACTTGGTCTTTTCCAGTGCTTCTCTCTTATG
GAGATCATCCCTGGAATCCAAAGCTCTCCAGTTTTCTAACCCAGTTAAGAGTTAAAAACAACCACAGGTCATGAGCAGTAGGCTTGGCAG
TTATACCCCATGCAGTCATAGGAGACTGCTCCATCATTCTCAGCACATAGGGTGCACATCTCACTATCTCTGGCATGAACCAGCCTTGCG
AACTTATACAGTCTCAGCCACTCTGCTTTGATGGTAATTCTTCACCACTGATCTCTCCTCACCATGCCCTTCCTGCATCCTTCCCCCAAC
CACCCACCAGAGGAGTTCTGGTCCCCAAACCAAAGAGTTGCCTGCAGGTTGGTAATGTGACTTTGTAGATATTCCTTGATTAAAGCCAGA
CCCTATTGGTATCCTTTTTGAAGTACTGGATCGAAATCTAATTGCTTTTTTTTTTAATTGTTGGGGAGAGGAGGATGAGCAGAACTCCTA
TGCAGCCTGAGAGAAGTTCTCTATGTGTCTGTATATGTACACCTCTGTGTGTGTGTGTGTAACCTCATGGTTGTGCTCAGGCTGACAGGG
AGGGCAAAGAGTGAAAAGGAAGCATCTCTTTCTTGTTATCCAACATTGCTTCAAAGATGCCCAACCCCCGTAGTAGCAGGCAGTTCCCAA
GTGGAGGGTCGGGGCAGAGGCCTCCACCAAGGCCATCAATAACCAGGTGTGAGCTACAGGTCTCTGTGTAATGTGAAGCTCTCCCGTATT
TCATTTCTGCACCCAGGGGGCGGCTCTGCAGGATTGCTTACGGAGAACTCTGTGTCTGGCACCTCTCTCCACAAGGCCCAGGCGCCCAGG
GTCCCACCGACCTGCCCAGGAATGCATCACATTGTTCTCTGGTGCTGTAATTTGGCTGCAGGAGCTAGGCTGAATGCCTCCCAGGGATGA
GAAACATACTCTCCCTGGCGTCCTCCCTTCGCCCCAGCTAGCTTGAGCTTCTGCCCTATGACCACTGAGTGCATTTAAATAAAAACCTCA
GAAAGACTGAGGAAAAAAAAATCCTAATTATCTCTCTTCTGTTAAGCCATGTAGAGACTCGTGTCCTGAGTGGGTCTGAGAATTTGGCAA
AGACTTACTGGTTGGTGTTCTTGATAAGGGAAGTGAGACAAAGGAGAAGAAATTACTCCCTGCAACAGGAGGAATAGAAATGAAGCAGTG
AGTGTTCAGAAATTAGATCTACAAGAAGTTTTGCAAACAGACCCTCAGGGCCAGGCAATGTTTGTTTTTGTTTTTTGTTTTTTGTTTTTT
TTTTTAATCTGAAGCCCCTGATTTTATTTTTCCAGCATCACTCTAAGGAAGAGTGTGGATTAGTGCCATTATTCAGGGCTGGTATTAATA
AAAGTTAGCTTTTATCTGCAGGGCTAGGTTAAGGCTGGCATTCTTACTTTTACATTAAAAAAACTGGCTACAGGCTGCGCAGCTGAGGTA
CTTCAGTCATGTGCCTTCTCTAAAGGATTCTTAGATCCTTAAAATATATAGTATGTTTTAAGTTTGTATCTAAATAGCACTTACTGTAAT
GTATTATACCTAAATGTTTATTAAAAGTTAGAAGAAATGAGTACCAACAGGAAGGAATGGAAGAGAGGAGAGGGGCTAAGACATTGCTGA
TCTGAGGGACAGACCTCTATCAAATAGAAGAGGGCTGGGAGAAGGGGTGATTAGAAGCAGAGTGAGGGAACTAAATGGAGCCCTGACTGC

>4219_4219_1_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000358039_length(amino acids)=939AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGK
EPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGET
IYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYD
DISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL
QHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEI

--------------------------------------------------------------
>4219_4219_2_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000360743_length(transcript)=5433nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGATACACTTGGGTGACTGGTAAAGAGCCACTTACATACTATGACATGAACCTGTCAGCTCAGGACCATCAGACCTTTTTCAC
CTGTGACACAGATTTTTTACGTCCTTCAGACACAGTTATGCAGAAGGCTTGGAGGGAAAGAAATCCTCCAGCTCGAATCAAAGCAGCCTA
TCAAGCTTTAGAATTAAACAATGACTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTT
ATTTAAACAGGCACTCAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAG
GAGAGATACCAATGTACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAAT
GAGAGATTTGATGAAAGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCC
AGATGTTCAGGCAGTCCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAG
GACTGTTTCAGAAAAATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGC
TGTGGAATTTAATCCTCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAG
TGAAGCAATTGCCTATGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCAC
CTTTCATCATGTTTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGATAGC
CATTCTCACTCACCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTCAGG
CTTTGAGGAGAATACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACAAAT
CACCAAATTTTTCTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCATTT
TGCATATGAAAAAGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAATTGT
CTTCCTTTTTTCTTCATTCAGCTTAGCCTTTCTGTTTGGCCAGGGCTACTTACAGGGGCTGTTGGGGTTGAAGTCAAGTCACCGCATTTT
GGCTCCTTTGGTCAAAGAGAAAGAACTCTAATGTCCAGCTGCTCCATCGATATACTCATAGAATGGAAGTGAGCAAAGGAAAATTTTAAG
CCAGGATAGTTAACCGTTAGGGGGCCAGTGGGAGAATGCTTGCCTTGCATTTGCACATCCAGAATGACTAAAACATCTTAAGTAAATGAG
GAATAGCCACCGAGATGCTCAGAGATAATATAAGCCATGAGTGGGAAGTGGGAAAATGAGTTTGTCAACGCCCTCTCTTTTCTATCCCTT
TACCTTTGAGGTCAGGGACAGGGCATATTACTGACACCCCACTGGCTATTGCCCTATACCTGCCAATCACCCAAAGAAAATAATAGCTTC
TGAGAAAGCTCAATTCACTGTAGCAACTGTGATATATTTACCCTAATAAAGCCACCACTTGGTCTTTTCCAGTGCTTCTCTCTTATGGAG
ATCATCCCTGGAATCCAAAGCTCTCCAGTTTTCTAACCCAGTTAAGAGTTAAAAACAACCACAGGTCATGAGCAGTAGGCTTGGCAGTTA
TACCCCATGCAGTCATAGGAGACTGCTCCATCATTCTCAGCACATAGGGTGCACATCTCACTATCTCTGGCATGAACCAGCCTTGCGAAC
TTATACAGTCTCAGCCACTCTGCTTTGATGGTAATTCTTCACCACTGATCTCTCCTCACCATGCCCTTCCTGCATCCTTCCCCCAACCAC
CCACCAGAGGAGTTCTGGTCCCCAAACCAAAGAGTTGCCTGCAGGTTGGTAATGTGACTTTGTAGATATTCCTTGATTAAAGCCAGACCC
TATTGGTATCCTTTTTGAAGTACTGGATCGAAATCTAATTGCTTTTTTTTTTAATTGTTGGGGAGAGGAGGATGAGCAGAACTCCTATGC
AGCCTGAGAGAAGTTCTCTATGTGTCTGTATATGTACACCTCTGTGTGTGTGTGTGTAACCTCATGGTTGTGCTCAGGCTGACAGGGAGG
GCAAAGAGTGAAAAGGAAGCATCTCTTTCTTGTTATCCAACATTGCTTCAAAGATGCCCAACCCCCGTAGTAGCAGGCAGTTCCCAAGTG
GAGGGTCGGGGCAGAGGCCTCCACCAAGGCCATCAATAACCAGGTGTGAGCTACAGGTCTCTGTGTAATGTGAAGCTCTCCCGTATTTCA
TTTCTGCACCCAGGGGGCGGCTCTGCAGGATTGCTTACGGAGAACTCTGTGTCTGGCACCTCTCTCCACAAGGCCCAGGCGCCCAGGGTC
CCACCGACCTGCCCAGGAATGCATCACATTGTTCTCTGGTGCTGTAATTTGGCTGCAGGAGCTAGGCTGAATGCCTCCCAGGGATGAGAA
ACATACTCTCCCTGGCGTCCTCCCTTCGCCCCAGCTAGCTTGAGCTTCTGCCCTATGACCACTGAGTGCATTTAAATAAAAACCTCAGAA
AGACTGAGGAAAAAAAAATCCTAATTATCTCTCTTCTGTTAAGCCATGTAGAGACTCGTGTCCTGAGTGGGTCTGAGAATTTGGCAAAGA
CTTACTGGTTGGTGTTCTTGATAAGGGAAGTGAGACAAAGGAGAAGAAATTACTCCCTGCAACAGGAGGAATAGAAATGAAGCAGTGAGT
GTTCAGAAATTAGATCTACAAGAAGTTTTGCAAACAGACCCTCAGGGCCAGGCAATGTTTGTTTTTGTTTTTTGTTTTTTGTTTTTTTTT
TTAATCTGAAGCCCCTGATTTTATTTTTCCAGCATCACTCTAAGGAAGAGTGTGGATTAGTGCCATTATTCAGGGCTGGTATTAATAAAA
GTTAGCTTTTATCTGCAGGGCTAGGTTAAGGCTGGCATTCTTACTTTTACATTAAAAAAACTGGCTACAGGCTGCGCAGCTGAGGTACTT
CAGTCATGTGCCTTCTCTAAAGGATTCTTAGATCCTTAAAATATATAGTATGTTTTAAGTTTGTATCTAAATAGCACTTACTGTAATGTA
TTATACCTAAATGTTTATTAAAAGTTAGAAGAAATGAGTACCAACAGGAAGGAATGGAAGAGAGGAGAGGGGCTAAGACATTGCTGATCT
GAGGGACAGACCTCTATCAAATAGAAGAGGGCTGGGAGAAGGGGTGATTAGAAGCAGAGTGAGGGAACTAAATGGAGCCCTGACTGCACC

>4219_4219_2_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000360743_length(amino acids)=908AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRRYTWVTGK
EPLTYYDMNLSAQDHQTFFTCDTDFLRPSDTVMQKAWRERNPPARIKAAYQALELNNDCATAYVLLAEEEATTIVDAERLFKQALKAGET
IYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNIHENLLESLLELQAYPDVQAVLAKYD
DISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL
QHWKRIEGALNLLQCTWEGTFHHVSVYPKKELPLFIHFTAGFCSSTAMIAILTHQFPEIMGIFAKAVLGLWCPQPWASSGFEENTQDLKS

--------------------------------------------------------------
>4219_4219_3_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000544629_length(transcript)=3090nt_BP=1591nt
CTCTTCCGCGCCGGCAGGGGCAGCAGCGGGAGCAGCGCGGGGCGGAGCGGCGCCAGCAGCCAGGAGCGGCCCGGCCCGGCCCGGCGCGGC
GGCGGCGGCGGCAGCGGCAGCGGCAGCGACGCCAGAGCCCGTGGGCGCCGTTCGCGAGGCCGCCGCAGAGGCCCGGCCGCAGCGCAGGGA
AGCCTGGGGGCCAGAGGTCGCCGCTGCCGCCATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCT
CAGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAGGCCGGCCCCGGCGAGCCGGACCAGCTAAC
GGCCTCGCTGCAGCCTGAGCCGCCGGCGCCCGCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGA
CAGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAGCTCATCCAGTGTATTGTGTTTGGCCCTCT
TCGAGTGAGTGAGAGACAGCATCTCAAAGACAAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCA
GACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTGATGGTTCAGCTCTGCAAGGATCGATTTGA
ATATCTTTCCTTCTCGCCCACCACGCCGATGAGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACT
GGCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCTGCAGAGTCTCTTCTTGTGACAGTGAGGAC
TGCTCATGTGATTTTACGATACGTAATTCACCTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACAC
AGACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTGTTATTTGGCAACATCTGGTTATCCATGGC
CAGCCTGGTCATCTTTATGCAGCTGCGTTACCTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGG
AAACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGACTGTGCCATCTGTTGGGACTCCATGCAGGC
TGCGCGGAAACTGCCCTGTGGACATCTTTTCCACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAAT
GTCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGATGAGAATTTGGTTCCTGTAGCAGCAGCCGA
AGGGAGACCTCGCTTAAACCAACACAATCACTTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGT
GATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATGATATTTGAATGGTGGTACTTCCATAAGCA
TGGCACATCTTTTATTGAGCAAGTATCTGTAAGCCATTTGCAACCACTGATGGGAGGAACAGAGAGCAGCATTTCAGAACCAGGTTCTCC
TTCGAGGAACAGAGAAAATGAAACCAGCAGACAGAATTTGTCAGAATGTAAGGTATGGAGAAACCCTCTAAATCTTTTCAGAGGAGCAGA
ATATAGGAGCTGTGCCACTGCATATGTTCTACTGGCTGAGGAAGAAGCAACAACTATTGTAGATGCTGAAAGGTTATTTAAACAGGCACT
CAAGGCAGGAGAAACAATTTATAGGCAGTCACAGCAGTGCCAGCACCAAAGTCCTCAGCATGAAGCTCAACTGAGGAGAGATACCAATGT
ACTGGTATATATTAAAAGAAGATTGGCAATGTGTGCAAGAAAATTAGGAAGAATAAGAGAAGCAGTAAAAATAATGAGAGATTTGATGAA
AGAATTTCCTCCTCTTACCATGTTGAACATCCATGAAAATCTCTTAGAATCACTTTTAGAATTACAGGCCTATCCAGATGTTCAGGCAGT
CCTAGCAAAATATGATGATATAAGCCTTCCAAAGTCAGCAGCAATCTGTTACACAGCAGCACTGTTGAAGACAAGGACTGTTTCAGAAAA
ATTCTCTCCAGAAACAGCCTCCAGAAGAGGATTAAGCACAGCAGAAATTAATGCCGTGGAAGCAATTCATAGAGCTGTGGAATTTAATCC
TCATGTTCCAAAATATTTATTAGAGATGAAAAGTTTAATTTTACCTCCAGAACACATTCTGAAACGGGGTGATAGTGAAGCAATTGCCTA
TGCTTTCTTTCATCTTCAGCACTGGAAACGAATAGAAGGTGCTCTTAATCTGTTACAGTGTACATGGGAAGGCACTTTTAGAATGATTCC
ATACCCGTTAGAGAAAGGACATCTATTTTACCCTTATCCCAGCTGCACAGAGACGGCTGATAGAGAGCTATTACCTACCTTTCATCATGT
TTCTGTTTACCCAAAAAAGGAGCTTCCTTTGTTCATCCATTTCACAGCAGGATTTTGCTCTTCTACAGCAATGATAGCCATTCTCACTCA
CCAGTTTCCTGAAATCATGGGTATTTTTGCTAAAGCTGTGCTGGGACTCTGGTGCCCCCAACCCTGGGCATCCTCAGGCTTTGAGGAGAA
TACACAGGATTTGAAGTCAGAAGACCTAGGTTTGAGTTCTGGCTGAGCCACGCACTGTTCATGTGACCTTGGACAAATCACCAAATTTTT
CTGAACAGCATCTGTAAAGTGACAGTAACCCCTACCTCACAGGGTTGTTGTGAGGATTACATATATGCTAAAGCATTTTGCATATGAAAA
AGCTTCTTATGAATATTGTTATTCCTAGGCAAACCCCCCTTGGAAGCTGTCAAAAAGGACAACTGTAGATGAAATTGTCTTCCTTTTTTC

>4219_4219_3_AMFR-ST7L_AMFR_chr16_56419831_ENST00000290649_ST7L_chr1_113153625_ENST00000544629_length(amino acids)=874AA_BP=460
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAPARPSAGGPRARDVAQYLLSDSLFVWVLVNT
ACCVLMLVAKLIQCIVFGPLRVSERQHLKDKFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIHLWDLNHEGTWEGKGTYVYYTDFVMELTLLS
LDLMHHIHMLLFGNIWLSMASLVIFMQLRYLFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNHFFHFDGSRIASWLPSFSVEVMHTTNILGIT
QASNSQLNAMIFEWWYFHKHGTSFIEQVSVSHLQPLMGGTESSISEPGSPSRNRENETSRQNLSECKVWRNPLNLFRGAEYRSCATAYVL
LAEEEATTIVDAERLFKQALKAGETIYRQSQQCQHQSPQHEAQLRRDTNVLVYIKRRLAMCARKLGRIREAVKIMRDLMKEFPPLTMLNI
HENLLESLLELQAYPDVQAVLAKYDDISLPKSAAICYTAALLKTRTVSEKFSPETASRRGLSTAEINAVEAIHRAVEFNPHVPKYLLEMK
SLILPPEHILKRGDSEAIAYAFFHLQHWKRIEGALNLLQCTWEGTFRMIPYPLEKGHLFYPYPSCTETADRELLPTFHHVSVYPKKELPL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for AMFR-ST7L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for AMFR-ST7L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for AMFR-ST7L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAMFRC0002395Alzheimer's Disease1CTD_human
HgeneAMFRC0005684Malignant neoplasm of urinary bladder1CTD_human
HgeneAMFRC0005695Bladder Neoplasm1CTD_human
HgeneAMFRC0011265Presenile dementia1CTD_human
HgeneAMFRC0235874Disease Exacerbation1CTD_human
HgeneAMFRC0276496Familial Alzheimer Disease (FAD)1CTD_human
HgeneAMFRC0494463Alzheimer Disease, Late Onset1CTD_human
HgeneAMFRC0546126Acute Confusional Senile Dementia1CTD_human
HgeneAMFRC0750900Alzheimer's Disease, Focal Onset1CTD_human
HgeneAMFRC0750901Alzheimer Disease, Early Onset1CTD_human