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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CPAMD8-SAP18 (FusionGDB2 ID:HG27151TG10284)

Fusion Gene Summary for CPAMD8-SAP18

check button Fusion gene summary
Fusion gene informationFusion gene name: CPAMD8-SAP18
Fusion gene ID: hg27151tg10284
HgeneTgene
Gene symbol

CPAMD8

SAP18

Gene ID

27151

10284

Gene nameC3 and PZP like alpha-2-macroglobulin domain containing 8Sin3A associated protein 18
SynonymsASGD8|K-CAP|VIP2HOR0202|SAP18P
Cytomap('CPAMD8')('SAP18')

19p13.11

13q12.11

Type of geneprotein-codingprotein-coding
DescriptionC3 and PZP-like alpha-2-macroglobulin domain-containing protein 8alpha-2 macroglobulin family protein VIPhistone deacetylase complex subunit SAP1818 kDa Sin3-associated polypeptideSin3A-associated protein, 18kDacell growth inhibiting protein 38cell growth-inhibiting gene 38 proteinepididymis secretory sperm binding proteinhistone deacetlyase complex su
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000443236, ENST00000597335, 
ENST00000388925, 
Fusion gene scores* DoF score8 X 6 X 5=2404 X 5 X 2=40
# samples 75
** MAII scorelog2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CPAMD8 [Title/Abstract] AND SAP18 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCPAMD8(17006987)-SAP18(21720944), # samples:2
Anticipated loss of major functional domain due to fusion event.CPAMD8-SAP18 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CPAMD8-SAP18 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSAP18

GO:0000381

regulation of alternative mRNA splicing, via spliceosome

20966198

TgeneSAP18

GO:0043065

positive regulation of apoptotic process

12665594

TgeneSAP18

GO:0048025

negative regulation of mRNA splicing, via spliceosome

12665594


check buttonFusion gene breakpoints across CPAMD8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across SAP18 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AN-A0FX-01ACPAMD8chr19

17006987

-SAP18chr13

21720944

+


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Fusion Gene ORF analysis for CPAMD8-SAP18

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000443236ENST00000485646CPAMD8chr19

17006987

-SAP18chr13

21720944

+
5UTR-3CDSENST00000597335ENST00000382533CPAMD8chr19

17006987

-SAP18chr13

21720944

+
5UTR-3CDSENST00000597335ENST00000607003CPAMD8chr19

17006987

-SAP18chr13

21720944

+
5UTR-intronENST00000597335ENST00000485646CPAMD8chr19

17006987

-SAP18chr13

21720944

+
In-frameENST00000443236ENST00000382533CPAMD8chr19

17006987

-SAP18chr13

21720944

+
In-frameENST00000443236ENST00000607003CPAMD8chr19

17006987

-SAP18chr13

21720944

+
intron-3CDSENST00000388925ENST00000382533CPAMD8chr19

17006987

-SAP18chr13

21720944

+
intron-3CDSENST00000388925ENST00000607003CPAMD8chr19

17006987

-SAP18chr13

21720944

+
intron-intronENST00000388925ENST00000485646CPAMD8chr19

17006987

-SAP18chr13

21720944

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000443236CPAMD8chr1917006987-ENST00000382533SAP18chr1321720944+76195599858781956
ENST00000443236CPAMD8chr1917006987-ENST00000607003SAP18chr1321720944+76195599858781956

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000443236ENST00000382533CPAMD8chr1917006987-SAP18chr1321720944+0.0009331530.9990669
ENST00000443236ENST00000607003CPAMD8chr1917006987-SAP18chr1321720944+0.0009331530.9990669

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Fusion Genomic Features for CPAMD8-SAP18


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CPAMD8chr1917006986-SAP18chr1321720943+0.0004945670.9995054
CPAMD8chr1917006986-SAP18chr1321720943+0.0004945670.9995054

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CPAMD8-SAP18


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:17006987/chr13:21720944)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCPAMD8chr19:17006987chr13:21720944ENST00000443236-41421242_124518551933.0Compositional biasNote=Poly-Gln
HgeneCPAMD8chr19:17006987chr13:21720944ENST00000443236-41421540_154318551933.0Compositional biasNote=Poly-Asp
HgeneCPAMD8chr19:17006987chr13:21720944ENST00000443236-41421765_176818551933.0Compositional biasNote=Poly-Ser
HgeneCPAMD8chr19:17006987chr13:21720944ENST00000443236-4142668_67118551933.0Compositional biasNote=Poly-Arg
HgeneCPAMD8chr19:17006987chr13:21720944ENST00000443236-41421706_175718551933.0DomainKazal-like
TgeneSAP18chr19:17006987chr13:21720944ENST000006070031493_15360154.0RegionNote=Involved in splicing regulation activity

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CPAMD8-SAP18


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>18897_18897_1_CPAMD8-SAP18_CPAMD8_chr19_17006987_ENST00000443236_SAP18_chr13_21720944_ENST00000382533_length(transcript)=7619nt_BP=5599nt
GCCCCAGCTTGGCCGGGCGCGGAGCGGGGCGCATGGCGCCGGGCGCACTGCGCGGGGGCTGCGAACAAAGGGCCCCCGGCGGCGGCGCGA
GGACGGCCGCGCTCGGACCCTGGCCCTGGCCCAGCCCTGGCCCGGCCCCCTCCCCAGGCGCGGCGCCCCCCAGGAGCCGAAAAATGAGCG
GCGCCCTGCTCTGGCCGTTGCTCCCGCTCCTGCTCCTGCTGCTGTCGGCGCGGGACGGCGTGCGCGCCGCGCAGCCTCAGGCCCCGGGTT
ACTTGATTGCAGCTCCCTCTGTTTTTCGCGCGGGCGTGGAGGAAGTCATCAGCGTGACCATCTTTAACTCTCCAAGGGAAGTCACGGTCC
AGGCTCAGCTGGTGGCCCAGGGTGAGCCGGTGGTGCAGAGCCAGGGAGCCATCCTGGATAAAGGGACAATCAAACTCAAGGTGCCCACGG
GCCTCCGGGGCCAAGCGCTTCTGAAAGTGTGGGGCCGCGGCTGGCAGGCGGAGGAGGGGCCCCTCTTTCACAACCAGACCTCGGTGACCG
TGGACGGCCGGGGCGCTTCTGTATTCATCCAGACGGACAAGCCTGTGTACAGACCCCAGCACCGAGTGCTCATAAGCATCTTCACCGTCT
CTCCAAATCTGAGGCCTGTCAACGAGAAGCTGGAAGCCTACATCCTGGACCCCCGAGGCTCTCGGATGATAGAGTGGAGACACTTAAAGC
CGTTCTGCTGCGGCATCACCAACATGAGCTTCCCCTTGTCCGACCAGCCTGTGTTGGGAGAATGGTTCATTTTTGTTGAAATGCAAGGCC
ACGCGTACAACAAGTCTTTTGAAGTTCAGAAGTATGTGTTGCCCAAGTTTGAGCTTCTGATTGACCCGCCCCGGTATATCCAAGACCTGG
ACGCCTGTGAGACAGGCACTGTGCGGGCCAGGTATACCTTTGGGAAACCTGTGGCTGGTGCCTTAATGATCAACATGACTGTTAATGGTG
TAGGGTACTACAGCCACGAGGTGGGACGCCCTGTCCTCAGAACAACCAAGATCCTCGGCTCCCGGGACTTCGACATCTGCGTGAGGGACA
TGATCCCAGCGGACGTCCCTGAGCACTTCCGGGGCAGGGTCAGCATCTGGGCCATGGTGACCAGTGTGGACGGGAGCCAGCAGGTCGCGT
TCGATGACTCCACCCCCGTGCAGAGGCAGCTGGTGGACATCCGGTACTCCAAGGACACGAGGAAGCAGTTCAAGCCGGGCCTGGCCTACG
TGGGGAAGGTGGAGCTATCCTACCCCGATGGCAGCCCAGCTGAGGGGGTGACGGTCCAGATTAAGGCAGAGCTGACACCAAAGGATAACA
TCTACACCAGTGAAGTTGTGTCCCAGCGTGGACTAGTGGGGTTTGAAATCCCCTCCATCCCCACGTCAGCCCAGCACGTGTGGCTGGAGA
CCAAGGTGATGGCACTGAACGGGAAGCCTGTGGGGGCTCAGTACCTGCCCAGCTACCTCTCCCTCGGCAGCTGGTACTCCCCCAGCCAGT
GCTACCTGCAGCTGCAGCCACCCTCCCACCCACTGCAGGTTGGGGAAGAAGCCTATTTTTCTGTGAAGTCCACATGTCCCTGCAACTTTA
CCCTGTACTACGAGGTGGCTGCACGGGGCAATATTGTGCTATCGGGCCAGCAGCCTGCCCACACCACCCAGCAGCGAAGCAAGCGGGCGG
CCCCTGCCCTGGAGAAACCGATTCGTTTAACACACCTTTCTGAGACAGAGCCCCCACCAGCCCCAGAAGCTGAGGTCGACGTGTGTGTGA
CCTCTCTTCATCTGGCCGTGACCCCCAGCATGGTCCCCCTTGGTCGCCTGCTGGTCTTCTACGTCAGGGAGAATGGAGAAGGGGTCGCCG
ACAGCCTTCAGTTTGCAGTCGAGACCTTCTTCGAAAACCAGGTTTCAGTGACGTATTCAGCAAATGAGACCCAACCTGGGGAGGTTGTCG
ACCTGCGGATCAGGGCTGCAAGGGGCAGCTGTGTGTGCGTCGCCGCAGTTGATAAGAGTGTCTACCTGCTCAGGTCTGGGTTCCGGCTGA
CTCCTGCCCAGGTTTTCCAGGAACTGGAAGATTATGATGTTTCTGATTCCTTTGGCGTGTCCAGGGAGGATGGTCCTTTTTGGTGGGCTG
GGCTGACGGCACAACGACGCCGGCGCTCCTCTGTCTTCCCGTGGCCTTGGGGCATCACCAAGGACTCTGGGTTTGCCTTCACCGAAACGG
GACTGGTGGTGATGACCGACCGAGTGAGCCTGAACCACCGGCAGGACGGTGGCCTCTACACCGATGAGGCTGTCCCCGCTTTCCAGCCCC
ACACAGGGAGCCTGGTGGCAGTGGCTCCTTCCAGGCACCCCCCCAGAACAGAGAAGAGAAAAAGGACTTTCTTCCCCGAAACATGGATTT
GGCATTGTCTCAACATCAGTGACCCATCTGGTGAGGGGACACTCAGTGTGAAGGTCCCGGACTCCATCACCAGCTGGGTGGGTGAGGCCG
TGGCCCTGTCCACCTCTCAGGGCTTAGGCATCGCCGAGCCCTCCCTGCTGAAGACCTTCAAGCCCTTCTTCGTGGACTTCATGCTCCCCG
CTCTCATCATCCGTGGGGAGCAGGTCAAGATCCCGCTCAGTGTCTACAACTACATGGGCACCTGCGCTGAGGTGTACATGAAGCTCTCGG
TTCCCAAGGGCATCCAGTTTGTTGGGCATCCTGGCAAACGCCATGTGACCAAGAAGATGTGTGTGGCCCCCGGGGAGGCTGAGCCCATCT
GGGTCGTTCTGTCCTTCAGCGACCTGGGACTCAACAACATCACGGCCAAAGCCCTTGCTTACGGAGACACAAATTGCTGCCGGGATGGGA
GGTCCAGCAAACACCCTGAGGAGAATCACGCCGACAGGAGGGTCCCCATCGGGGTGGATCACGTCAGGCGCAGTGTGATGGTTGAGGCGG
AAGGAGTCCCCCGGGCGTACACCTACAGCGCATTCTTCTGTCCCAGTGAGAGAGTCCACATCTCCACCCCCAACAAGTATGAGTTCCAGT
ATGTGCAGCGGCCACTGCGCCTCACCCGCTTTGATGTGGCTGTGCGAGCTCACAATGATGCCCGTGTGGCCTTGTCTTCTGGGCCCCAGG
ACACAGCAGGCATGATCGAGATCGTCCTGGGGGGGCATCAGAACACCAGGTCATGGATCTCCACCAGCAAGATGGGAGAGCCCGTGGCCA
GTGCACACACGGCCAAGATCCTCTCCTGGGATGAATTCAGAACATTCTGGATCAGCTGGCGTGGTGGCCTTATCCAGGTTGGCCATGGTC
CAGAGCCATCCAATGAGTCTGTCATTGTGGCCTGGACCCTCCCGAGGCCACCAGAGGTCCAGTTCATTGGCTTTTCCACCGGCTGGGGCT
CCATGGGTGAATTCCGAATCTGGAGGAAGATGGAGGTGGACGAGAGCTACAGCGAGGCCTTCACCCTGGGGGTCCCACACGGCGCCATCC
CTGGGTCTGAGCGAGCCACCGCCTCCATCATCGGGGACGTCATGGGGCCAACCCTGAACCACCTCAACAACCTCCTGCGGCTGCCGTTTG
GCTGTGGAGAGCAGAACATGATCCACTTTGCACCCAACGTCTTTGTCTTGAAGTATCTTCAGAAAACCCAGCAGCTCAGCCCTGAGGTGG
AGAGAGAGACCACCGACTACCTAGTACAAGGCTACCAGCGCCAGCTGACCTACAAGCGCCAGGATGGCTCCTACAGCGCGTTTGGGGAGC
GGGACGCATCGGGGAGCATGTGGCTCACAGCCTTTGTCCTGAAGTCCTTCGCACAGGCTCGCAGCTTTATCTTCGTGGACCCCCGGGAGC
TGGCTGCCGCCAAGAGCTGGATCATCCAGCAGCAGCAGGCCGATGGCTCCTTCCTGGCCGTGGGCAGGGTCCTGAACAAGGACATCCAGG
GTGGGATCCACGGCACTGTCCCGCTGACAGCCTACGTGGTGGTTGCTCTCCTGGAAACAGGCACAGCCTCAGAGGAGGAGAGAGGCTCCA
CTGACAAAGCGAGGCACTTCCTGGAGTCTGCTGCGCCCCTGGCCATGGACCCTTATAGCTGTGCCCTGACTACCTACGCGCTGACCCTGC
TCCGCAGCCCGGCAGCCCCTGAGGCACTGCGCAAGCTCCGTAGCCTGGCCATCATGCGAGATGGGGTCACCCACTGGAGCCTGTCAAATT
CCTGGGACGTGGACAAGGGCACATTCTTGAGCTTCAGTGACAGGGTCTCTCAGTCAGTGGTCTCGGCCGAGGTGGAAATGACAGCCTACG
CCCTTCTGACCTACACTCTGCTGGGTGACGTGGCTGCCGCCCTGCCTGTGGTGAAGTGGCTGTCCCAGCAGCGAAATGCACTTGGGGGCT
TCTCCTCCACTCAGGACACCTGCGTGGCTCTGCAGGCCTTGGCTGAATATGCCATCTTGTCCTATGCTGGAGGCATCAACCTCACTGTCT
CCCTGGCCTCCACCAACCTGGACTACCAGGAAACCTTCGAGCTGCACAGGACCAACCAGAAGGTTCTGCAGACAGCAGCGATCCCCAGCC
TCCCCACGGGGCTGTTTGTGAGTGCCAAGGGGGACGGCTGCTGCCTGATGCAGATTGATGTCACCTACAATGTGCCTGACCCGGTGGCCA
AGCCAGCTTTCCAGCTGCTCGTAAGCCTCCAGGAGCCTGAGGCCCAGGGACGCCCGCCCCCCATGCCTGCCTCCGCAGCTGAGGGTTCCC
GAGGAGACTGGCCCCCAGCTGACGATGATGACCCAGCGGCCGATCAGCATCACCAGGAATACAAGGTGATGCTGGAGGTGTGCACCAGGT
GGCTGCATGCAGGGTCTTCCAATATGGCTGTCCTGGAGGTGCCCCTGCTGTCAGGCTTCCGGGCAGACATCGAGAGCCTGGAGCAGCTGC
TCCTTGACAAGCACATGGGGATGAAGAGGTATGAAGTGGCTGGACGCCGAGTGCTCTTCTACTTTGATGAGATCCCCAGCCGGTGCCTGA
CGTGCGTGCGGTTCCGTGCTCTCCGGGAGTGCGTGGTGGGCAGGACGTCGGCGCTGCCAGTCTCCGTGTACGACTACTACGAACCCGCCT
TCGAGGCCACTCGCTTCTACAACGTCAGCACCCACAGCCCACTCGCCCGGGAACTGTGCGCCGGACCCGCGTGCAACGAAGTGGAGCGCG
CCCCTGCCCGGGGCCCGGGCTGGTTCCCCGGCGAGTCGGGCCCTGCCGTGGCCCCTGAGGAGGGGGCGGCGATCGCGCGATGCGGCTGCG
ACCACGACTGCGGCGCCCAGGGGAACCCGGTGTGCGGCTCCGACGGGGTGGTCTACGCCAGCGCCTGCCGCCTGCGGGAGGCCGCCTGCC
GCCAGGCCGCGCCCCTGGAGCCCGCGCCTCCCAGCTGCTGCGCCCTCGAGCAGCGGCTGCCGGCCTCGTCGTCCTCCACCTACGGGGATG
ACCTGGCTTCTGTGGCCCCGGGGCCTTTACAGCAGGACGTGAAGCTGAATGGAGCCGGCCTTGAGGTGGAGGACTCAGACCCTGAGCCTG
AAGGGGAGGCGGAGGACAGGATGGATGCAACCTTGAAAGAACTGACAAGCTTAGTAAAAGAAGTCTACCCAGAAGCTAGAAAGAAGGGCA
CTCACTTCAATTTTGCAATCGTTTTTACAGATGTTAAAAGACCTGGCTATCGAGTTAAGGAGATTGGCAGCACCATGTCTGGCAGAAAGG
GGACTGATGATTCCATGACCCTGCAGTCGCAGAAGTTCCAGATAGGAGATTACTTGGACATAGCAATTACCCCTCCAAATCGGGCACCAC
CTCCTTCAGGGCGCATGAGACCATATTAAATTCTATTTACTATTTGTTGAATTTATTTTTCCGTCAGTTATGTAAAATAAACATACTCTT
CTTCCTCCCCTGATTATTGCCATTAAGCCTTTAAATTCTAAACAAATTATAATGCATCATCTATTTAGGAGTTAGATTTGGATGTGCTAT
TGTATGATTACGAATAGTCTGTATGTTTCAAGCCCTTCTGTAAAATATGAAGAAAAGTGCTCTTAGCATTCTGTGTAAAACTGTACTGTT
AAATATATGTGTGTAATCAGCCTGAGTGTGAAAGTTAATGGAGGCCTGGGAACAGGGTTTATACTAAGTAGTGGAGGAGCGTATGGTTAA
GCCCAAAGGGGCAGAACAAGAAAGCCACGGGATTGTATGAAATCAAACATGAGTTTGTGGTGTAGACTGCTGTATGCAGTTGGAAAGGAC
ACGTGAGAGTGAGCTCAAGTGGCAGCAGAGGCAGTTTGGAATAAGCTGCGGCAAGTTGAAGAAGCTGTGTTGGACGAGATTGCCCCGCCT
TGATCAGGGTACCATGACATAAAAGGTTAAAGAACAGGCAACACAATGAGCACTTAAGTTTTTAACATGTGGGGAATAGGGCATTTTAAA
GGCTGGAACCAGTTCAGAGGAAACAAGGGTTTGGGTAGAGGTAGAAAGGTTTAATTAACCCTGGAGATCTGCAAATGGAGGGAGGGGTGA
AGGAGGAATCTTAAGACCGAGGGAGAAGAGCCAAGGACAAGGTCAGGTTGAATGAGTAGGAGGTGTTCACACATCCTCTTGTGTGCTAGG
TAGTGGCGTGCATCTGATCTGAGAGGCAGTAAAGCAGTGATGAAGACAGTGCAGCAGAACATTGAAGTCCTGATTGCAGCAGTGACTCTG
CAACCTTGGATAAATTATTTCAATCTTTATTTTGTAAAACGGAGATAACGGCCTATAGGATTGTTAAGACTGAATATTTTAAAAGAGCTT
AGAATGGTGCCTGACAAATGAGAAACAATAAATACTGATTATTGGCCATAAAGTGGTATTAAAACTGGATCTCTTTTCTTCCATGGCACT
ACTCTCATTTTGAAGTTTATGAACAGTACGACAGTGTATTGTAAATTCCCTTTAGTTTGTTACAGTAGCCAATTGAAAATGTATATCCCA
AAATTTAAAAAAAAAAGTACCAGCAGCAATAAAATTGCACTAGTTTTATCTGGTACATACAAAAACAGCCATTTAAAATCTGATGATTCT
GTGGAATTGGTGTCCCTGTTAGCAATGGCAGAGACCAGCCTGGAGCCTAGATCTGGTGCTTCTTCTGTGCTGTGGTTTACCCCAAACCTT
TAGGTTGTTTATTCATTCAGATTAGATAGACTGGAGCCATAAAGTTAATTTGCACCTAGCTTTTTGGAGAATAGCCATGATTAACTGCTA
TTCGTGGTGGGGGTGGGGGGGAACCCTATGATTTACTATGCAGATGAAGAGGGTAGGAACTAAATAAAGGACTTTGTAAGCCAAAGTGGT
TGGGCTGCTTTGTCAAATTCCACCCTTTGCTTGGTTCCAACATGGAATTTCTCCTTTAAAGATTTCAATATCCCATCAAAAGTACAGTTA
GAGAATACCTAGTGAATTTATTGAATATAATGCTAAGAATCAAAAGACTTGTACTAGTTTACCTCTGGCTTTGGTAAGTGTGGCTTTGAG

>18897_18897_1_CPAMD8-SAP18_CPAMD8_chr19_17006987_ENST00000443236_SAP18_chr13_21720944_ENST00000382533_length(amino acids)=1956AA_BP=1863
MAGRGAGRMAPGALRGGCEQRAPGGGARTAALGPWPWPSPGPAPSPGAAPPRSRKMSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLI
AAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDG
RGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAY
NKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIP
ADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYT
SEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLY
YEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSL
QFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLT
AQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHC
LNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPK
GIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGV
PRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAH
TAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGS
ERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDA
SGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDK
ARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALL
TYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPT
GLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLH
AGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEA
TRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQA
APLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRMDATLKELTSLVKEVYPEARKKGTHF

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>18897_18897_2_CPAMD8-SAP18_CPAMD8_chr19_17006987_ENST00000443236_SAP18_chr13_21720944_ENST00000607003_length(transcript)=7619nt_BP=5599nt
GCCCCAGCTTGGCCGGGCGCGGAGCGGGGCGCATGGCGCCGGGCGCACTGCGCGGGGGCTGCGAACAAAGGGCCCCCGGCGGCGGCGCGA
GGACGGCCGCGCTCGGACCCTGGCCCTGGCCCAGCCCTGGCCCGGCCCCCTCCCCAGGCGCGGCGCCCCCCAGGAGCCGAAAAATGAGCG
GCGCCCTGCTCTGGCCGTTGCTCCCGCTCCTGCTCCTGCTGCTGTCGGCGCGGGACGGCGTGCGCGCCGCGCAGCCTCAGGCCCCGGGTT
ACTTGATTGCAGCTCCCTCTGTTTTTCGCGCGGGCGTGGAGGAAGTCATCAGCGTGACCATCTTTAACTCTCCAAGGGAAGTCACGGTCC
AGGCTCAGCTGGTGGCCCAGGGTGAGCCGGTGGTGCAGAGCCAGGGAGCCATCCTGGATAAAGGGACAATCAAACTCAAGGTGCCCACGG
GCCTCCGGGGCCAAGCGCTTCTGAAAGTGTGGGGCCGCGGCTGGCAGGCGGAGGAGGGGCCCCTCTTTCACAACCAGACCTCGGTGACCG
TGGACGGCCGGGGCGCTTCTGTATTCATCCAGACGGACAAGCCTGTGTACAGACCCCAGCACCGAGTGCTCATAAGCATCTTCACCGTCT
CTCCAAATCTGAGGCCTGTCAACGAGAAGCTGGAAGCCTACATCCTGGACCCCCGAGGCTCTCGGATGATAGAGTGGAGACACTTAAAGC
CGTTCTGCTGCGGCATCACCAACATGAGCTTCCCCTTGTCCGACCAGCCTGTGTTGGGAGAATGGTTCATTTTTGTTGAAATGCAAGGCC
ACGCGTACAACAAGTCTTTTGAAGTTCAGAAGTATGTGTTGCCCAAGTTTGAGCTTCTGATTGACCCGCCCCGGTATATCCAAGACCTGG
ACGCCTGTGAGACAGGCACTGTGCGGGCCAGGTATACCTTTGGGAAACCTGTGGCTGGTGCCTTAATGATCAACATGACTGTTAATGGTG
TAGGGTACTACAGCCACGAGGTGGGACGCCCTGTCCTCAGAACAACCAAGATCCTCGGCTCCCGGGACTTCGACATCTGCGTGAGGGACA
TGATCCCAGCGGACGTCCCTGAGCACTTCCGGGGCAGGGTCAGCATCTGGGCCATGGTGACCAGTGTGGACGGGAGCCAGCAGGTCGCGT
TCGATGACTCCACCCCCGTGCAGAGGCAGCTGGTGGACATCCGGTACTCCAAGGACACGAGGAAGCAGTTCAAGCCGGGCCTGGCCTACG
TGGGGAAGGTGGAGCTATCCTACCCCGATGGCAGCCCAGCTGAGGGGGTGACGGTCCAGATTAAGGCAGAGCTGACACCAAAGGATAACA
TCTACACCAGTGAAGTTGTGTCCCAGCGTGGACTAGTGGGGTTTGAAATCCCCTCCATCCCCACGTCAGCCCAGCACGTGTGGCTGGAGA
CCAAGGTGATGGCACTGAACGGGAAGCCTGTGGGGGCTCAGTACCTGCCCAGCTACCTCTCCCTCGGCAGCTGGTACTCCCCCAGCCAGT
GCTACCTGCAGCTGCAGCCACCCTCCCACCCACTGCAGGTTGGGGAAGAAGCCTATTTTTCTGTGAAGTCCACATGTCCCTGCAACTTTA
CCCTGTACTACGAGGTGGCTGCACGGGGCAATATTGTGCTATCGGGCCAGCAGCCTGCCCACACCACCCAGCAGCGAAGCAAGCGGGCGG
CCCCTGCCCTGGAGAAACCGATTCGTTTAACACACCTTTCTGAGACAGAGCCCCCACCAGCCCCAGAAGCTGAGGTCGACGTGTGTGTGA
CCTCTCTTCATCTGGCCGTGACCCCCAGCATGGTCCCCCTTGGTCGCCTGCTGGTCTTCTACGTCAGGGAGAATGGAGAAGGGGTCGCCG
ACAGCCTTCAGTTTGCAGTCGAGACCTTCTTCGAAAACCAGGTTTCAGTGACGTATTCAGCAAATGAGACCCAACCTGGGGAGGTTGTCG
ACCTGCGGATCAGGGCTGCAAGGGGCAGCTGTGTGTGCGTCGCCGCAGTTGATAAGAGTGTCTACCTGCTCAGGTCTGGGTTCCGGCTGA
CTCCTGCCCAGGTTTTCCAGGAACTGGAAGATTATGATGTTTCTGATTCCTTTGGCGTGTCCAGGGAGGATGGTCCTTTTTGGTGGGCTG
GGCTGACGGCACAACGACGCCGGCGCTCCTCTGTCTTCCCGTGGCCTTGGGGCATCACCAAGGACTCTGGGTTTGCCTTCACCGAAACGG
GACTGGTGGTGATGACCGACCGAGTGAGCCTGAACCACCGGCAGGACGGTGGCCTCTACACCGATGAGGCTGTCCCCGCTTTCCAGCCCC
ACACAGGGAGCCTGGTGGCAGTGGCTCCTTCCAGGCACCCCCCCAGAACAGAGAAGAGAAAAAGGACTTTCTTCCCCGAAACATGGATTT
GGCATTGTCTCAACATCAGTGACCCATCTGGTGAGGGGACACTCAGTGTGAAGGTCCCGGACTCCATCACCAGCTGGGTGGGTGAGGCCG
TGGCCCTGTCCACCTCTCAGGGCTTAGGCATCGCCGAGCCCTCCCTGCTGAAGACCTTCAAGCCCTTCTTCGTGGACTTCATGCTCCCCG
CTCTCATCATCCGTGGGGAGCAGGTCAAGATCCCGCTCAGTGTCTACAACTACATGGGCACCTGCGCTGAGGTGTACATGAAGCTCTCGG
TTCCCAAGGGCATCCAGTTTGTTGGGCATCCTGGCAAACGCCATGTGACCAAGAAGATGTGTGTGGCCCCCGGGGAGGCTGAGCCCATCT
GGGTCGTTCTGTCCTTCAGCGACCTGGGACTCAACAACATCACGGCCAAAGCCCTTGCTTACGGAGACACAAATTGCTGCCGGGATGGGA
GGTCCAGCAAACACCCTGAGGAGAATCACGCCGACAGGAGGGTCCCCATCGGGGTGGATCACGTCAGGCGCAGTGTGATGGTTGAGGCGG
AAGGAGTCCCCCGGGCGTACACCTACAGCGCATTCTTCTGTCCCAGTGAGAGAGTCCACATCTCCACCCCCAACAAGTATGAGTTCCAGT
ATGTGCAGCGGCCACTGCGCCTCACCCGCTTTGATGTGGCTGTGCGAGCTCACAATGATGCCCGTGTGGCCTTGTCTTCTGGGCCCCAGG
ACACAGCAGGCATGATCGAGATCGTCCTGGGGGGGCATCAGAACACCAGGTCATGGATCTCCACCAGCAAGATGGGAGAGCCCGTGGCCA
GTGCACACACGGCCAAGATCCTCTCCTGGGATGAATTCAGAACATTCTGGATCAGCTGGCGTGGTGGCCTTATCCAGGTTGGCCATGGTC
CAGAGCCATCCAATGAGTCTGTCATTGTGGCCTGGACCCTCCCGAGGCCACCAGAGGTCCAGTTCATTGGCTTTTCCACCGGCTGGGGCT
CCATGGGTGAATTCCGAATCTGGAGGAAGATGGAGGTGGACGAGAGCTACAGCGAGGCCTTCACCCTGGGGGTCCCACACGGCGCCATCC
CTGGGTCTGAGCGAGCCACCGCCTCCATCATCGGGGACGTCATGGGGCCAACCCTGAACCACCTCAACAACCTCCTGCGGCTGCCGTTTG
GCTGTGGAGAGCAGAACATGATCCACTTTGCACCCAACGTCTTTGTCTTGAAGTATCTTCAGAAAACCCAGCAGCTCAGCCCTGAGGTGG
AGAGAGAGACCACCGACTACCTAGTACAAGGCTACCAGCGCCAGCTGACCTACAAGCGCCAGGATGGCTCCTACAGCGCGTTTGGGGAGC
GGGACGCATCGGGGAGCATGTGGCTCACAGCCTTTGTCCTGAAGTCCTTCGCACAGGCTCGCAGCTTTATCTTCGTGGACCCCCGGGAGC
TGGCTGCCGCCAAGAGCTGGATCATCCAGCAGCAGCAGGCCGATGGCTCCTTCCTGGCCGTGGGCAGGGTCCTGAACAAGGACATCCAGG
GTGGGATCCACGGCACTGTCCCGCTGACAGCCTACGTGGTGGTTGCTCTCCTGGAAACAGGCACAGCCTCAGAGGAGGAGAGAGGCTCCA
CTGACAAAGCGAGGCACTTCCTGGAGTCTGCTGCGCCCCTGGCCATGGACCCTTATAGCTGTGCCCTGACTACCTACGCGCTGACCCTGC
TCCGCAGCCCGGCAGCCCCTGAGGCACTGCGCAAGCTCCGTAGCCTGGCCATCATGCGAGATGGGGTCACCCACTGGAGCCTGTCAAATT
CCTGGGACGTGGACAAGGGCACATTCTTGAGCTTCAGTGACAGGGTCTCTCAGTCAGTGGTCTCGGCCGAGGTGGAAATGACAGCCTACG
CCCTTCTGACCTACACTCTGCTGGGTGACGTGGCTGCCGCCCTGCCTGTGGTGAAGTGGCTGTCCCAGCAGCGAAATGCACTTGGGGGCT
TCTCCTCCACTCAGGACACCTGCGTGGCTCTGCAGGCCTTGGCTGAATATGCCATCTTGTCCTATGCTGGAGGCATCAACCTCACTGTCT
CCCTGGCCTCCACCAACCTGGACTACCAGGAAACCTTCGAGCTGCACAGGACCAACCAGAAGGTTCTGCAGACAGCAGCGATCCCCAGCC
TCCCCACGGGGCTGTTTGTGAGTGCCAAGGGGGACGGCTGCTGCCTGATGCAGATTGATGTCACCTACAATGTGCCTGACCCGGTGGCCA
AGCCAGCTTTCCAGCTGCTCGTAAGCCTCCAGGAGCCTGAGGCCCAGGGACGCCCGCCCCCCATGCCTGCCTCCGCAGCTGAGGGTTCCC
GAGGAGACTGGCCCCCAGCTGACGATGATGACCCAGCGGCCGATCAGCATCACCAGGAATACAAGGTGATGCTGGAGGTGTGCACCAGGT
GGCTGCATGCAGGGTCTTCCAATATGGCTGTCCTGGAGGTGCCCCTGCTGTCAGGCTTCCGGGCAGACATCGAGAGCCTGGAGCAGCTGC
TCCTTGACAAGCACATGGGGATGAAGAGGTATGAAGTGGCTGGACGCCGAGTGCTCTTCTACTTTGATGAGATCCCCAGCCGGTGCCTGA
CGTGCGTGCGGTTCCGTGCTCTCCGGGAGTGCGTGGTGGGCAGGACGTCGGCGCTGCCAGTCTCCGTGTACGACTACTACGAACCCGCCT
TCGAGGCCACTCGCTTCTACAACGTCAGCACCCACAGCCCACTCGCCCGGGAACTGTGCGCCGGACCCGCGTGCAACGAAGTGGAGCGCG
CCCCTGCCCGGGGCCCGGGCTGGTTCCCCGGCGAGTCGGGCCCTGCCGTGGCCCCTGAGGAGGGGGCGGCGATCGCGCGATGCGGCTGCG
ACCACGACTGCGGCGCCCAGGGGAACCCGGTGTGCGGCTCCGACGGGGTGGTCTACGCCAGCGCCTGCCGCCTGCGGGAGGCCGCCTGCC
GCCAGGCCGCGCCCCTGGAGCCCGCGCCTCCCAGCTGCTGCGCCCTCGAGCAGCGGCTGCCGGCCTCGTCGTCCTCCACCTACGGGGATG
ACCTGGCTTCTGTGGCCCCGGGGCCTTTACAGCAGGACGTGAAGCTGAATGGAGCCGGCCTTGAGGTGGAGGACTCAGACCCTGAGCCTG
AAGGGGAGGCGGAGGACAGGATGGATGCAACCTTGAAAGAACTGACAAGCTTAGTAAAAGAAGTCTACCCAGAAGCTAGAAAGAAGGGCA
CTCACTTCAATTTTGCAATCGTTTTTACAGATGTTAAAAGACCTGGCTATCGAGTTAAGGAGATTGGCAGCACCATGTCTGGCAGAAAGG
GGACTGATGATTCCATGACCCTGCAGTCGCAGAAGTTCCAGATAGGAGATTACTTGGACATAGCAATTACCCCTCCAAATCGGGCACCAC
CTCCTTCAGGGCGCATGAGACCATATTAAATTCTATTTACTATTTGTTGAATTTATTTTTCCGTCAGTTATGTAAAATAAACATACTCTT
CTTCCTCCCCTGATTATTGCCATTAAGCCTTTAAATTCTAAACAAATTATAATGCATCATCTATTTAGGAGTTAGATTTGGATGTGCTAT
TGTATGATTACGAATAGTCTGTATGTTTCAAGCCCTTCTGTAAAATATGAAGAAAAGTGCTCTTAGCATTCTGTGTAAAACTGTACTGTT
AAATATATGTGTGTAATCAGCCTGAGTGTGAAAGTTAATGGAGGCCTGGGAACAGGGTTTATACTAAGTAGTGGAGGAGCGTATGGTTAA
GCCCAAAGGGGCAGAACAAGAAAGCCACGGGATTGTATGAAATCAAACATGAGTTTGTGGTGTAGACTGCTGTATGCAGTTGGAAAGGAC
ACGTGAGAGTGAGCTCAAGTGGCAGCAGAGGCAGTTTGGAATAAGCTGCGGCAAGTTGAAGAAGCTGTGTTGGACGAGATTGCCCCGCCT
TGATCAGGGTACCATGACATAAAAGGTTAAAGAACAGGCAACACAATGAGCACTTAAGTTTTTAACATGTGGGGAATAGGGCATTTTAAA
GGCTGGAACCAGTTCAGAGGAAACAAGGGTTTGGGTAGAGGTAGAAAGGTTTAATTAACCCTGGAGATCTGCAAATGGAGGGAGGGGTGA
AGGAGGAATCTTAAGACCGAGGGAGAAGAGCCAAGGACAAGGTCAGGTTGAATGAGTAGGAGGTGTTCACACATCCTCTTGTGTGCTAGG
TAGTGGCGTGCATCTGATCTGAGAGGCAGTAAAGCAGTGATGAAGACAGTGCAGCAGAACATTGAAGTCCTGATTGCAGCAGTGACTCTG
CAACCTTGGATAAATTATTTCAATCTTTATTTTGTAAAACGGAGATAACGGCCTATAGGATTGTTAAGACTGAATATTTTAAAAGAGCTT
AGAATGGTGCCTGACAAATGAGAAACAATAAATACTGATTATTGGCCATAAAGTGGTATTAAAACTGGATCTCTTTTCTTCCATGGCACT
ACTCTCATTTTGAAGTTTATGAACAGTACGACAGTGTATTGTAAATTCCCTTTAGTTTGTTACAGTAGCCAATTGAAAATGTATATCCCA
AAATTTAAAAAAAAAAGTACCAGCAGCAATAAAATTGCACTAGTTTTATCTGGTACATACAAAAACAGCCATTTAAAATCTGATGATTCT
GTGGAATTGGTGTCCCTGTTAGCAATGGCAGAGACCAGCCTGGAGCCTAGATCTGGTGCTTCTTCTGTGCTGTGGTTTACCCCAAACCTT
TAGGTTGTTTATTCATTCAGATTAGATAGACTGGAGCCATAAAGTTAATTTGCACCTAGCTTTTTGGAGAATAGCCATGATTAACTGCTA
TTCGTGGTGGGGGTGGGGGGGAACCCTATGATTTACTATGCAGATGAAGAGGGTAGGAACTAAATAAAGGACTTTGTAAGCCAAAGTGGT
TGGGCTGCTTTGTCAAATTCCACCCTTTGCTTGGTTCCAACATGGAATTTCTCCTTTAAAGATTTCAATATCCCATCAAAAGTACAGTTA
GAGAATACCTAGTGAATTTATTGAATATAATGCTAAGAATCAAAAGACTTGTACTAGTTTACCTCTGGCTTTGGTAAGTGTGGCTTTGAG

>18897_18897_2_CPAMD8-SAP18_CPAMD8_chr19_17006987_ENST00000443236_SAP18_chr13_21720944_ENST00000607003_length(amino acids)=1956AA_BP=1863
MAGRGAGRMAPGALRGGCEQRAPGGGARTAALGPWPWPSPGPAPSPGAAPPRSRKMSGALLWPLLPLLLLLLSARDGVRAAQPQAPGYLI
AAPSVFRAGVEEVISVTIFNSPREVTVQAQLVAQGEPVVQSQGAILDKGTIKLKVPTGLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDG
RGASVFIQTDKPVYRPQHRVLISIFTVSPNLRPVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAY
NKSFEVQKYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEVGRPVLRTTKILGSRDFDICVRDMIP
ADVPEHFRGRVSIWAMVTSVDGSQQVAFDDSTPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTPKDNIYT
SEVVSQRGLVGFEIPSIPTSAQHVWLETKVMALNGKPVGAQYLPSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTLY
YEVAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPSMVPLGRLLVFYVRENGEGVADSL
QFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVAAVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPFWWAGLT
AQRRRRSSVFPWPWGITKDSGFAFTETGLVVMTDRVSLNHRQDGGLYTDEAVPAFQPHTGSLVAVAPSRHPPRTEKRKRTFFPETWIWHC
LNISDPSGEGTLSVKVPDSITSWVGEAVALSTSQGLGIAEPSLLKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEVYMKLSVPK
GIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDGRSSKHPEENHADRRVPIGVDHVRRSVMVEAEGV
PRAYTYSAFFCPSERVHISTPNKYEFQYVQRPLRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAH
TAKILSWDEFRTFWISWRGGLIQVGHGPEPSNESVIVAWTLPRPPEVQFIGFSTGWGSMGEFRIWRKMEVDESYSEAFTLGVPHGAIPGS
ERATASIIGDVMGPTLNHLNNLLRLPFGCGEQNMIHFAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGERDA
SGSMWLTAFVLKSFAQARSFIFVDPRELAAAKSWIIQQQQADGSFLAVGRVLNKDIQGGIHGTVPLTAYVVVALLETGTASEEERGSTDK
ARHFLESAAPLAMDPYSCALTTYALTLLRSPAAPEALRKLRSLAIMRDGVTHWSLSNSWDVDKGTFLSFSDRVSQSVVSAEVEMTAYALL
TYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGINLTVSLASTNLDYQETFELHRTNQKVLQTAAIPSLPT
GLFVSAKGDGCCLMQIDVTYNVPDPVAKPAFQLLVSLQEPEAQGRPPPMPASAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLH
AGSSNMAVLEVPLLSGFRADIESLEQLLLDKHMGMKRYEVAGRRVLFYFDEIPSRCLTCVRFRALRECVVGRTSALPVSVYDYYEPAFEA
TRFYNVSTHSPLARELCAGPACNEVERAPARGPGWFPGESGPAVAPEEGAAIARCGCDHDCGAQGNPVCGSDGVVYASACRLREAACRQA
APLEPAPPSCCALEQRLPASSSSTYGDDLASVAPGPLQQDVKLNGAGLEVEDSDPEPEGEAEDRMDATLKELTSLVKEVYPEARKKGTHF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CPAMD8-SAP18


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CPAMD8-SAP18


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CPAMD8-SAP18


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCPAMD8C4310622ANTERIOR SEGMENT DYSGENESIS 82GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCPAMD8C0009402Colorectal Carcinoma1CTD_human
HgeneCPAMD8C0009404Colorectal Neoplasms1CTD_human
HgeneCPAMD8C0017601Glaucoma1GENOMICS_ENGLAND
HgeneCPAMD8C0035305Retinal Detachment1GENOMICS_ENGLAND
HgeneCPAMD8C0086543Cataract1GENOMICS_ENGLAND
HgeneCPAMD8C0266525Irido-corneal dysgenesis1GENOMICS_ENGLAND