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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:EIF2C2-CHRAC1 (FusionGDB2 ID:HG27161TG54108)

Fusion Gene Summary for EIF2C2-CHRAC1

check button Fusion gene summary
Fusion gene informationFusion gene name: EIF2C2-CHRAC1
Fusion gene ID: hg27161tg54108
HgeneTgene
Gene symbol

EIF2C2

CHRAC1

Gene ID

27161

54108

Gene nameargonaute RISC catalytic component 2chromatin accessibility complex subunit 1
SynonymsCASC7|EIF2C2|LINC00980|PPD|Q10CHARC1|CHARC15|CHRAC-1|CHRAC-15|CHRAC15|YCL1
Cytomap('AGO2','EIF2C2')('CHRAC1','CHRAC1')

8q24.3

8q24.3

Type of geneprotein-codingprotein-coding
Descriptionprotein argonaute-2PAZ Piwi domain proteinargonaute 2, RISC catalytic componentcancer susceptibility candidate 7cancer susceptibility candidate 7 (non-protein coding)eukaryotic translation initiation factor 2C, 2long intergenic non-protein coding RNchromatin accessibility complex protein 1DNA polymerase epsilon subunit p15chromatin accessibility complex 1chromatin accessibility complex 15 kDa proteinhistone-fold protein CHRAC15
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000220592, ENST00000519980, 
ENST00000517293, 
Fusion gene scores* DoF score13 X 13 X 12=20283 X 2 X 3=18
# samples 284
** MAII scorelog2(28/2028*10)=-2.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: EIF2C2 [Title/Abstract] AND CHRAC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAGO2(141645584)-CHRAC1(141524468), # samples:2
EIF2C2(141645584)-CHRAC1(141524468), # samples:1
Anticipated loss of major functional domain due to fusion event.AGO2-CHRAC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AGO2-CHRAC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneEIF2C2

GO:0010501

RNA secondary structure unwinding

19966796

HgeneEIF2C2

GO:0031054

pre-miRNA processing

16424907|17671087|18178619|19966796

HgeneEIF2C2

GO:0035087

siRNA loading onto RISC involved in RNA interference

19966796

HgeneEIF2C2

GO:0035196

production of miRNAs involved in gene silencing by miRNA

19966796|23661684

HgeneEIF2C2

GO:0035278

miRNA mediated inhibition of translation

17671087|19801630

HgeneEIF2C2

GO:0035279

mRNA cleavage involved in gene silencing by miRNA

15260970|17524464

HgeneEIF2C2

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

18178619|19966796

HgeneEIF2C2

GO:0045766

positive regulation of angiogenesis

27208409

HgeneEIF2C2

GO:0045947

negative regulation of translational initiation

17524464|19801630

HgeneEIF2C2

GO:0090625

mRNA cleavage involved in gene silencing by siRNA

15260970

HgeneEIF2C2

GO:1905618

positive regulation of miRNA mediated inhibition of translation

23409027


check buttonFusion gene breakpoints across AGO2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CHRAC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-IB-A6UF-01AAGO2chr8

141645584

-CHRAC1chr8

141524468

+
ChimerDB4PAADTCGA-IB-A6UF-01AEIF2C2chr8

141645584

-CHRAC1chr8

141524468

+
ChimerDB4PAADTCGA-IB-A6UFAGO2chr8

141615896

-CHRAC1chr8

141524468

+
ChimerDB4PAADTCGA-IB-A6UFAGO2chr8

141645584

-CHRAC1chr8

141524468

+


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Fusion Gene ORF analysis for EIF2C2-CHRAC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000220592ENST00000519533AGO2chr8

141645584

-CHRAC1chr8

141524468

+
5CDS-intronENST00000519980ENST00000519533AGO2chr8

141645584

-CHRAC1chr8

141524468

+
5UTR-3CDSENST00000517293ENST00000220913AGO2chr8

141645584

-CHRAC1chr8

141524468

+
5UTR-intronENST00000517293ENST00000519533AGO2chr8

141645584

-CHRAC1chr8

141524468

+
In-frameENST00000220592ENST00000220913AGO2chr8

141645584

-CHRAC1chr8

141524468

+
In-frameENST00000519980ENST00000220913AGO2chr8

141645584

-CHRAC1chr8

141524468

+
intron-3CDSENST00000220592ENST00000220913AGO2chr8

141615896

-CHRAC1chr8

141524468

+
intron-3CDSENST00000517293ENST00000220913AGO2chr8

141615896

-CHRAC1chr8

141524468

+
intron-3CDSENST00000519980ENST00000220913AGO2chr8

141615896

-CHRAC1chr8

141524468

+
intron-intronENST00000220592ENST00000519533AGO2chr8

141615896

-CHRAC1chr8

141524468

+
intron-intronENST00000517293ENST00000519533AGO2chr8

141615896

-CHRAC1chr8

141524468

+
intron-intronENST00000519980ENST00000519533AGO2chr8

141615896

-CHRAC1chr8

141524468

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000220592AGO2chr8141645584-ENST00000220913CHRAC1chr8141524468+227413555080484
ENST00000519980AGO2chr8141645584-ENST00000220913CHRAC1chr8141524468+22016247773184

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000220592ENST00000220913AGO2chr8141645584-CHRAC1chr8141524468+0.3260390.673961
ENST00000519980ENST00000220913AGO2chr8141645584-CHRAC1chr8141524468+0.43809990.56190014

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Fusion Genomic Features for EIF2C2-CHRAC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
AGO2chr8141645583-CHRAC1chr8141524467+5.47E-070.9999994
AGO2chr8141645583-CHRAC1chr8141524467+5.47E-070.9999994
AGO2chr8141645583-CHRAC1chr8141524467+5.47E-070.9999994
AGO2chr8141645583-CHRAC1chr8141524467+5.47E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for EIF2C2-CHRAC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:141645584/:141524468)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCHRAC1chr8:141645584chr8:141524468ENST0000022091303100_12449132.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119235_3487860.0DomainPAZ
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119517_8187860.0DomainPiwi
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118235_3487826.0DomainPAZ
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118517_8187826.0DomainPiwi


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Fusion Gene Sequence for EIF2C2-CHRAC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2901_2901_1_AGO2-CHRAC1_AGO2_chr8_141645584_ENST00000220592_CHRAC1_chr8_141524468_ENST00000220913_length(transcript)=2274nt_BP=135nt
GGCCGCGCCGGGGCGGATCGTGCGGCCGGCGGCTCCCTCGCGGCTCGCGGCGTCGGGGCCCGTGGCGCGCGCGCGGCCGCCCCTCGGCCC
CGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGGAGCTCTTTGTTCAATGCCTAGCCACCTATTCCTACAGACACGGC
AGTGGAAAGGAAAAGAAAGTACTGACTTACAGTGATTTAGCAAACACTGCACAGCAATCAGAAACTTTTCAGTTTCTTGCAGATATATTA
CCAAAGAAGATTTTAGCTAGTAAATACCTGAAAATGCTTAAAGAGGAAAAGAGGGAAGAAGATGAGGAGAATGACAATGATAATGAAAGT
GACCATGATGAAGCTGACTCCTAAACCAAAAGTGCTTTAAAAACCAGCCTGGCGAGGACAGCCCTGGACCCACTCCACTGTCTCTAAGTA
AACACAGCACTGCCCGCTTTTAGCGTCTTCACTTCTTCACAGAGTTCCAGTGTGTGGTATTCTTTCGAGGTATTCTTTCCAGGCCGAGAT
TGAGCACCTCATGTACCTACGCCACAGACAGCCAGAGGGAAAGCGACCCAGACAGCAGCCCCTCCTCGACAGGCCCACCCTGCAGCTCAG
GCACCAAGAAAACAGCCGATACTGGCAGCCATTGCAGCTCCAAACTGCAGAGGCAAGGCCAATTTTAACTTTTCAATTTACAGTCGATTT
TGAAGAGCTTCTACATATCGGTTATGTAAATTCATATATGTATATTTTGGAATCAGTTCTTATAAACAGCTCGATTCAGTTTTAGCTAAA
TTTATAGTTTAGGTAGTATGTTACATTTGAATTTTTGTCTTAAGAAAAGTTGACTGTTCAGATATTTTTCTACTGTAAAGAAATATACTT
TTCTATTAAAGATCTGTACATATTTTTACAGTAAAATGCTTTATGGAACTAGTTTTAGAGCCCTCTATGGCTTTAAGGCCTTGCTTACTG
CCTGCAAATTTTGAGAAATTTAAAAATAAGCATTCTAACACTTTTATTCCCACAGAAAAATTCCAAGTCAAATTATCAAATCAAATACAA
AAATAAGTCTTACCTCTTGTATAAGCATGTTGTACTAAAAAAAAATTTTGAAACATTTTGTATATTGGAGATCTCTCTCATCTTACTGTT
CTTTGCTTTAAATTCCTGGCACTTCTTTTTACTGTCTATAAGAGAAAACCTATCATAAGCCCAATTTTTTTTTTCCACTTAGGGTAAATG
TTTGGCTCCTCTCATTTCATTATCTTTTTTTTTTTTTTTTTAAAGACAGATTCTCACTCAGTTGCCCAGGCTGGATTGCGGTGGCGCTGT
CTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCATCCTCCTGAGTAGCTGGGATTACAGGCGTGTGCCACCA
TGCCCAACCTATTTTTGTATTTTTTAGTAGAGACGGGGTTCACCATGTTGGCCAGGCTTGTCTCAAACTCCTAACCTCAACTGATCCACC
TGCCTCAGCCTCCCAAAGTGCCGCCGGGATTACAGGCGTGAGCCACCATGCCTGGCCTTCATTATCTCTTTTTTAAAAATGAAAAAGTTT
ATAATTTACATTCAGTAAAATCACCCTTTTTAGTGTCTAGTCTGTGAATTTTGACAAATGCATGGTTTTGTAACCAATCGATAGGACAGT
TCTGCCACCCAGGACATTCCCCTCTGTTCCTCTGTTCCTCTCTTCTCCTGCCCCCTAGCAACCACTGGTGTTTTCTGTCCCTCTTGTTCA
TTGACATTTATTTTAAAATAAAATATTTTAAAATCTACTTTTTGGTGTACAGTTCTGAGTTTTGGCAAATGCAGTCAAGTCACTACCACC
ACCACAATTAACAGCTATATCACCCTCCAGTAAATTCCCTGTGGTCAGCTCCTTCCCCACCTTTTACCGTGGCAACCGTCAAGCTATTCT
CTGTCCCTATACCAGGTGTCATCAAATTTTTTTCTGGAAAGGGCCATGCAGTAAATAGTTCAAGCTTTGTGGGCTTTTATAGTCTCTGTT
GCTGCTGCTGAACTCAGCTGTTGTAGCACGAAAGCAGCCAGGTAATTACTAGATGAAGGAATGCAGGTGGCTGTGTTTCAATAGAGCTTT
ATTTCTGCAAACTGAAACTTGAGTTTTGTGTAATTTTCATGTGTCATGAAATACTGTTTTCTCCAACCATTTAATAATGTAAATACTTGC
TAGCTTATGTGCCATTAAAAAATG

>2901_2901_1_AGO2-CHRAC1_AGO2_chr8_141645584_ENST00000220592_CHRAC1_chr8_141524468_ENST00000220913_length(amino acids)=84AA_BP=
MYLRHRQPEGKRPRQQPLLDRPTLQLRHQENSRYWQPLQLQTAEARPILTFQFTVDFEELLHIGYVNSYMYILESVLINSSIQF

--------------------------------------------------------------
>2901_2901_2_AGO2-CHRAC1_AGO2_chr8_141645584_ENST00000519980_CHRAC1_chr8_141524468_ENST00000220913_length(transcript)=2201nt_BP=62nt
CGGCCGCCCCTCGGCCCCGGAGCCCCTCGGCGGCGCCACCATGTACTCGGGAGCCGGCCCCGGAGCTCTTTGTTCAATGCCTAGCCACCT
ATTCCTACAGACACGGCAGTGGAAAGGAAAAGAAAGTACTGACTTACAGTGATTTAGCAAACACTGCACAGCAATCAGAAACTTTTCAGT
TTCTTGCAGATATATTACCAAAGAAGATTTTAGCTAGTAAATACCTGAAAATGCTTAAAGAGGAAAAGAGGGAAGAAGATGAGGAGAATG
ACAATGATAATGAAAGTGACCATGATGAAGCTGACTCCTAAACCAAAAGTGCTTTAAAAACCAGCCTGGCGAGGACAGCCCTGGACCCAC
TCCACTGTCTCTAAGTAAACACAGCACTGCCCGCTTTTAGCGTCTTCACTTCTTCACAGAGTTCCAGTGTGTGGTATTCTTTCGAGGTAT
TCTTTCCAGGCCGAGATTGAGCACCTCATGTACCTACGCCACAGACAGCCAGAGGGAAAGCGACCCAGACAGCAGCCCCTCCTCGACAGG
CCCACCCTGCAGCTCAGGCACCAAGAAAACAGCCGATACTGGCAGCCATTGCAGCTCCAAACTGCAGAGGCAAGGCCAATTTTAACTTTT
CAATTTACAGTCGATTTTGAAGAGCTTCTACATATCGGTTATGTAAATTCATATATGTATATTTTGGAATCAGTTCTTATAAACAGCTCG
ATTCAGTTTTAGCTAAATTTATAGTTTAGGTAGTATGTTACATTTGAATTTTTGTCTTAAGAAAAGTTGACTGTTCAGATATTTTTCTAC
TGTAAAGAAATATACTTTTCTATTAAAGATCTGTACATATTTTTACAGTAAAATGCTTTATGGAACTAGTTTTAGAGCCCTCTATGGCTT
TAAGGCCTTGCTTACTGCCTGCAAATTTTGAGAAATTTAAAAATAAGCATTCTAACACTTTTATTCCCACAGAAAAATTCCAAGTCAAAT
TATCAAATCAAATACAAAAATAAGTCTTACCTCTTGTATAAGCATGTTGTACTAAAAAAAAATTTTGAAACATTTTGTATATTGGAGATC
TCTCTCATCTTACTGTTCTTTGCTTTAAATTCCTGGCACTTCTTTTTACTGTCTATAAGAGAAAACCTATCATAAGCCCAATTTTTTTTT
TCCACTTAGGGTAAATGTTTGGCTCCTCTCATTTCATTATCTTTTTTTTTTTTTTTTTAAAGACAGATTCTCACTCAGTTGCCCAGGCTG
GATTGCGGTGGCGCTGTCTCAGCTCACTGCAACCTCCGCCTCCCAGGTTCAAGTGATTCTCCTGCCTCATCCTCCTGAGTAGCTGGGATT
ACAGGCGTGTGCCACCATGCCCAACCTATTTTTGTATTTTTTAGTAGAGACGGGGTTCACCATGTTGGCCAGGCTTGTCTCAAACTCCTA
ACCTCAACTGATCCACCTGCCTCAGCCTCCCAAAGTGCCGCCGGGATTACAGGCGTGAGCCACCATGCCTGGCCTTCATTATCTCTTTTT
TAAAAATGAAAAAGTTTATAATTTACATTCAGTAAAATCACCCTTTTTAGTGTCTAGTCTGTGAATTTTGACAAATGCATGGTTTTGTAA
CCAATCGATAGGACAGTTCTGCCACCCAGGACATTCCCCTCTGTTCCTCTGTTCCTCTCTTCTCCTGCCCCCTAGCAACCACTGGTGTTT
TCTGTCCCTCTTGTTCATTGACATTTATTTTAAAATAAAATATTTTAAAATCTACTTTTTGGTGTACAGTTCTGAGTTTTGGCAAATGCA
GTCAAGTCACTACCACCACCACAATTAACAGCTATATCACCCTCCAGTAAATTCCCTGTGGTCAGCTCCTTCCCCACCTTTTACCGTGGC
AACCGTCAAGCTATTCTCTGTCCCTATACCAGGTGTCATCAAATTTTTTTCTGGAAAGGGCCATGCAGTAAATAGTTCAAGCTTTGTGGG
CTTTTATAGTCTCTGTTGCTGCTGCTGAACTCAGCTGTTGTAGCACGAAAGCAGCCAGGTAATTACTAGATGAAGGAATGCAGGTGGCTG
TGTTTCAATAGAGCTTTATTTCTGCAAACTGAAACTTGAGTTTTGTGTAATTTTCATGTGTCATGAAATACTGTTTTCTCCAACCATTTA
ATAATGTAAATACTTGCTAGCTTATGTGCCATTAAAAAATG

>2901_2901_2_AGO2-CHRAC1_AGO2_chr8_141645584_ENST00000519980_CHRAC1_chr8_141524468_ENST00000220913_length(amino acids)=84AA_BP=
MYLRHRQPEGKRPRQQPLLDRPTLQLRHQENSRYWQPLQLQTAEARPILTFQFTVDFEELLHIGYVNSYMYILESVLINSSIQF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for EIF2C2-CHRAC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119311_3167.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119524_5667.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119709_7107.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119753_7617.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119790_8127.333333333333333860.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118311_3167.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118524_5667.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118709_7107.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118753_7617.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118790_8127.333333333333333826.0guide RNA
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119587_5907.333333333333333860.0GW182 family members
HgeneAGO2chr8:141645584chr8:141524468ENST00000220592-119650_6607.333333333333333860.0GW182 family members
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118587_5907.333333333333333826.0GW182 family members
HgeneAGO2chr8:141645584chr8:141524468ENST00000519980-118650_6607.333333333333333826.0GW182 family members


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for EIF2C2-CHRAC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for EIF2C2-CHRAC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAGO2C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneAGO2C0009171Cocaine Abuse1CTD_human
HgeneAGO2C0023466Leukemia, Monocytic, Chronic1CTD_human
HgeneAGO2C0023470Myeloid Leukemia1CTD_human
HgeneAGO2C0236736Cocaine-Related Disorders1CTD_human
HgeneAGO2C0345967Malignant mesothelioma1CTD_human
HgeneAGO2C0600427Cocaine Dependence1CTD_human