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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ARFIP1-FGB (FusionGDB2 ID:HG27236TG2244)

Fusion Gene Summary for ARFIP1-FGB

Fusion gene summary

Fusion gene information	Fusion gene name: ARFIP1-FGB
	Fusion gene ID: hg27236tg2244
		Hgene	Tgene
	Gene symbol	ARFIP1	FGB
	Gene ID	27236	2244
	Gene name	ADP ribosylation factor interacting protein 1	fibrinogen beta chain
	Synonyms	HSU52521	HEL-S-78p
	Cytomap	('ARFIP1')('FGB') 4q31.3	4q31.3
	Type of gene	protein-coding	protein-coding
	Description	arfaptin-1	fibrinogen beta chainbeta-fibrinogenepididymis secretory sperm binding protein Li 78pfibrinogen, B beta polypeptide
	Modification date	20200313	20200313
	UniProtAcc	P53367	P02675
	Ensembl transtripts involved in fusion gene	ENST00000353617, ENST00000356064, ENST00000405727, ENST00000429148, ENST00000451320, ENST00000511289,
Fusion gene scores	* DoF score	11 X 7 X 7=539	4 X 5 X 2=40
	# samples	11	5
	** MAII score	log2(11/539*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/40*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: ARFIP1 [Title/Abstract] AND FGB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ARFIP1(153750878)-FGB(155486960), # samples:3
Anticipated loss of major functional domain due to fusion event.	ARFIP1-FGB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARFIP1-FGB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ARFIP1-FGB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ARFIP1-FGB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ARFIP1	GO:0006886	intracellular protein transport	12606037
Hgene	ARFIP1	GO:0050708	regulation of protein secretion	12606037
Tgene	FGB	GO:0007160	cell-matrix adhesion	10903502
Tgene	FGB	GO:0031639	plasminogen activation	16846481
Tgene	FGB	GO:0034116	positive regulation of heterotypic cell-cell adhesion	8100742
Tgene	FGB	GO:0034622	cellular protein-containing complex assembly	8910396
Tgene	FGB	GO:0042730	fibrinolysis	16846481
Tgene	FGB	GO:0043152	induction of bacterial agglutination	24367264
Tgene	FGB	GO:0045907	positive regulation of vasoconstriction	15739255
Tgene	FGB	GO:0045921	positive regulation of exocytosis	19193866
Tgene	FGB	GO:0050714	positive regulation of protein secretion	19193866
Tgene	FGB	GO:0051258	protein polymerization	12706644
Tgene	FGB	GO:0051592	response to calcium ion	6777381
Tgene	FGB	GO:0070374	positive regulation of ERK1 and ERK2 cascade	10903502\|19193866
Tgene	FGB	GO:0070527	platelet aggregation	6281794
Tgene	FGB	GO:0072378	blood coagulation, fibrin clot formation	16846481
Tgene	FGB	GO:0090277	positive regulation of peptide hormone secretion	19193866
Tgene	FGB	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	10903502
Tgene	FGB	GO:2000352	negative regulation of endothelial cell apoptotic process	10903502

Fusion gene breakpoints across ARFIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across FGB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-D8-A13Z-01A	ARFIP1	chr4	153750878	-	FGB	chr4	155486960	+
ChimerDB4	BRCA	TCGA-D8-A13Z-01A	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+

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Fusion Gene ORF analysis for ARFIP1-FGB

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000353617	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-3UTR	ENST00000356064	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-3UTR	ENST00000405727	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-3UTR	ENST00000429148	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-3UTR	ENST00000451320	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-intron	ENST00000353617	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-intron	ENST00000356064	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-intron	ENST00000405727	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-intron	ENST00000429148	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
5CDS-intron	ENST00000451320	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
In-frame	ENST00000353617	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
In-frame	ENST00000356064	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
In-frame	ENST00000405727	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
In-frame	ENST00000429148	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
In-frame	ENST00000451320	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
intron-3CDS	ENST00000511289	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
intron-3UTR	ENST00000511289	ENST00000502545	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+
intron-intron	ENST00000511289	ENST00000509493	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000451320

ARFIP1

chr4

153750878

ENST00000302068

FGB

chr4

155486960

2055

257

1618

510

ENST00000429148

ARFIP1

chr4

153750878

ENST00000302068

FGB

chr4

155486960

2053

255

1616

510

ENST00000353617

ARFIP1

chr4

153750878

ENST00000302068

FGB

chr4

155486960

2167

369

1730

555

ENST00000405727

ARFIP1

chr4

153750878

ENST00000302068

FGB

chr4

155486960

2021

223

1584

510

ENST00000356064

ARFIP1

chr4

153750878

ENST00000302068

FGB

chr4

155486960

2142

344

1705

555

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000451320	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+	0.00040122	0.9995988
ENST00000429148	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+	0.000392686	0.9996074
ENST00000353617	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+	0.000433676	0.99956626
ENST00000405727	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+	0.000427758	0.9995722
ENST00000356064	ENST00000302068	ARFIP1	chr4	153750878	+	FGB	chr4	155486960	+	0.000469682	0.9995303

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Fusion Genomic Features for ARFIP1-FGB

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ARFIP1	chr4	153750878	+	FGB	chr4	155486959	+	1.84E-07	0.99999976
ARFIP1	chr4	153750878	+	FGB	chr4	155486959	+	1.84E-07	0.99999976

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ARFIP1-FGB

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:153750878/chr4:155486960)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ARFIP1 P53367	FGB P02675
FUNCTION: Plays a role in controlling biogenesis of secretory granules at the trans-Golgi network (PubMed:22981988). Mechanisitically, binds ARF-GTP at the neck of a growing secretory granule precursor and forms a protective scaffold (PubMed:9038142, PubMed:22981988). Once the granule precursor has been completely loaded, active PRKD1 phosphorylates ARFIP1 and releases it from ARFs (PubMed:22981988). In turn, ARFs induce fission (PubMed:22981988). Through this mechanism, ensures proper secretory granule formation at the Golgi of pancreatic beta cells (PubMed:22981988). {ECO:0000269\|PubMed:22981988, ECO:0000269\|PubMed:9038142}.	FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250\|UniProtKB:E9PV24}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

FGB

chr4:153750878

chr4:155486960

ENST00000302068

157_222

492.0

Coiled coil

Ontology_term=ECO:0000305,ECO:0000305,ECO:0000305

Tgene

FGB

chr4:153750878

chr4:155486960

ENST00000302068

232_488

492.0

Domain

Fibrinogen C-terminal

Tgene

FGB

chr4:153750878

chr4:155486960

ENST00000302068

45_47

492.0

Region

Note=Beta-chain polymerization%2C binding distal domain of another fibrin

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ARFIP1

chr4:153750878

chr4:155486960

ENST00000353617

153_353

374.0

Domain

Hgene

ARFIP1

chr4:153750878

chr4:155486960

ENST00000356064

153_353

342.0

Domain

Hgene

ARFIP1

chr4:153750878

chr4:155486960

ENST00000405727

153_353

342.0

Domain

Hgene

ARFIP1

chr4:153750878

chr4:155486960

ENST00000451320

153_353

374.0

Domain

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Fusion Gene Sequence for ARFIP1-FGB

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>5894_5894_1_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000353617_FGB_chr4_155486960_ENST00000302068_length(transcript)=2167nt_BP=369nt
ACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAA
TTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGTGCGTGGGGGAAGGGGAAGAAGGAAAAGGTCCGGGTCGCGTTTCCGC
TCAGTTTTTGCCAGGGTTGAGGCGATTCCAGAGAGCGGCGGAAAGGATAAGCCTCGACTTAGAAGCTACCGAGTTACCCTAAGAAAGGAG
TCTACCATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGC
TTTAATAGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCC
ATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGT
CTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAAT
AGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGG
CAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAG
ACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGAT
GTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATC
AGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAA
AATGGAGGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAAT
GTTGCAACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATG
GGACCCACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCC
AACAAATACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGG
ACCATGACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCT
AAAGAAGACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGAC
ATGGCAAAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGG
CCCTTCTTCCCACAGCAATAGTCCCCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTT
CTTTCATACATTATATTCCTCTAAAACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCA
CATGATTTTCTTTTGTTTTCTTCATTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGT
TCTAGTTGATTGCGAGAATTTTCAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTT
TAAAAGTCCACTTTTAAAACTATATTTATTTATGTAGGATCTGTCAAAGAAAACTTCCAAAAAGATTTATTAATTAAACCAGACTCTGTT

>5894_5894_1_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000353617_FGB_chr4_155486960_ENST00000302068_length(amino acids)=555AA_BP=102
MSSAVGQCEFVTAAVAPRPRAAEVRGGRGRRKRSGSRFRSVFARVEAIPESGGKDKPRLRSYRVTLRKESTMAQESPKNSAAEIPVTSNG
EVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEAL
LQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLR
SKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKW
DPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDG
ASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYS

--------------------------------------------------------------
>5894_5894_2_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000356064_FGB_chr4_155486960_ENST00000302068_length(transcript)=2142nt_BP=344nt
CTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCC
GCCCCCGAGCAGCCGAGGTGCGTGGGGGAAGGGGAAGAAGGAAAAGGTCCGGGTCGCGTTTCCGCTCAGTTTTTGCCAGGGTTGAGGCGA
TTCCAGAGAGCGGCGGAAAGGATAAGCCTCGACTTAGAAGCTACCGAGTTACCCTAAGAAAGGAGTCTACCATGGCTCAAGAATCTCCCA
AAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCCC
GTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTC
GTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGG
TGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATG
TGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAG
ATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACTA
ACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTC
GCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAA
TGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAGA
ACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAGA
ATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAAA
TGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAACA
AATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATGT
TCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGGT
ATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGATG
GTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCCC
CAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAAA
ACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCAT
TTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCAA
ATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATAT

>5894_5894_2_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000356064_FGB_chr4_155486960_ENST00000302068_length(amino acids)=555AA_BP=102
MSSAVGQCEFVTAAVAPRPRAAEVRGGRGRRKRSGSRFRSVFARVEAIPESGGKDKPRLRSYRVTLRKESTMAQESPKNSAAEIPVTSNG
EVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEAL
LQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLR
SKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKW
DPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDG
ASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYS

--------------------------------------------------------------
>5894_5894_3_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000405727_FGB_chr4_155486960_ENST00000302068_length(transcript)=2021nt_BP=223nt
CGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGC
TGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTCCCAAAAATTCAGCAGCAGAAATTCCAGTGACTAG
TAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCCCGTGGTCATCGACCCCTTGACAAGAAGAGAGA
AGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAA
AGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGA
GGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTC
CTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAAGATAATGAAAATGTAGTCAATGAGTACTCCTC
AGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAA
CCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGTCGCACCCCATGCACTGTCAGTTGCAATATTCC
TGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAAATGTATCTCATTCAACCTGACAGTTCTGTCAA
ACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAGAACCGTCAAGACGGTAGTGTTGACTTTGGCAG
GAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAGAATTACTGTGGCCTACCAGGTGAATATTGGCT
TGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAAATGGAGGACTGGAAAGGAGACAAAGTAAAGGC
TCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAACAAATACAGAGGAACAGCCGGTAATGCCCTCAT
GGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATGTTCTTCAGCACGTATGACAGAGACAATGACGG
CTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGGTATAATAGATGTCATGCAGCCAATCCAAACGG
CAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGATGGTGTAGTATGGATGAATTGGAAGGGGTCATG
GTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCCCCAATACGTAGATTTTTGCTCTTCTGTATGTG
ACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAAAACTCTCAAGCAGACGTGAGTGTGACTTTTTG
AAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCATTTCTCTTGCTCACCAAGAAGTAACAAAAGTA
TAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGT
AGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATATTTATTTATGTAGGATCTGTCAAAGAAAACTT

>5894_5894_3_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000405727_FGB_chr4_155486960_ENST00000302068_length(amino acids)=510AA_BP=57
MSSAVGQCEFVTAAVAPRPRAAEESTMAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGY
RARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQ
VKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGET
SEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELL
IEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGG

--------------------------------------------------------------
>5894_5894_4_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000429148_FGB_chr4_155486960_ENST00000302068_length(transcript)=2053nt_BP=255nt
AACGCTACTTCCGGTCTCCTCACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGTCC
TCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTCCC
AAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTGCC
CGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGGCT
CGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGGGG
GTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACAAT
GTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAAAA
GATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAACT
AACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATTGT
CGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTGAA
ATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTCAG
AACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGAAG
AATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAGAA
ATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGAAC
AAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCATG
TTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGTGG
TATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATGAT
GGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGTCC
CCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCTAA
AACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTTCA
TTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTTCA
AATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTATA

>5894_5894_4_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000429148_FGB_chr4_155486960_ENST00000302068_length(amino acids)=510AA_BP=57
MSSAVGQCEFVTAAVAPRPRAAEESTMAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGY
RARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQ
VKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGET
SEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELL
IEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGG

--------------------------------------------------------------
>5894_5894_5_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000451320_FGB_chr4_155486960_ENST00000302068_length(transcript)=2055nt_BP=257nt
ACAACGCTACTTCCGGTCTCCTCACTTCCGGCTTCGCTGCTCTTGGTTCTGGTTCTGGAGGCTGGGTTGAGAGGTCGCCGGTCCGACTGT
CCTCGGCGGTTGGTCAGTGTGAATTTGTGACAGCTGCAGTTGCTCCCCGCCCCCGAGCAGCCGAGGAGTCTACCATGGCTCAAGAATCTC
CCAAAAATTCAGCAGCAGAAATTCCAGTGACTAGTAATGGAGAAGTTGATGACTCTCGTGAACATAGCTTTAATAGGGGTTTCTTCAGTG
CCCGTGGTCATCGACCCCTTGACAAGAAGAGAGAAGAGGCTCCCAGCCTGAGGCCTGCCCCACCGCCCATCAGTGGAGGTGGCTATCGGG
CTCGTCCAGCCAAAGCAGCTGCCACTCAAAAGAAAGTAGAAAGAAAAGCCCCTGATGCTGGAGGCTGTCTTCACGCTGACCCAGACCTGG
GGGTGTTGTGTCCTACAGGATGTCAGTTGCAAGAGGCTTTGCTACAACAGGAAAGGCCAATCAGAAATAGTGTTGATGAGTTAAATAACA
ATGTGGAAGCTGTTTCCCAGACCTCCTCTTCTTCCTTTCAGTACATGTATTTGCTGAAAGACCTGTGGCAAAAGAGGCAGAAGCAAGTAA
AAGATAATGAAAATGTAGTCAATGAGTACTCCTCAGAACTGGAAAAGCACCAATTATATATAGATGAGACTGTGAATAGCAATATCCCAA
CTAACCTTCGTGTGCTTCGTTCAATCCTGGAAAACCTGAGAAGCAAAATACAAAAGTTAGAATCTGATGTCTCAGCTCAAATGGAATATT
GTCGCACCCCATGCACTGTCAGTTGCAATATTCCTGTGGTGTCTGGCAAAGAATGTGAGGAAATTATCAGGAAAGGAGGTGAAACATCTG
AAATGTATCTCATTCAACCTGACAGTTCTGTCAAACCGTATAGAGTATACTGTGACATGAATACAGAAAATGGAGGATGGACAGTGATTC
AGAACCGTCAAGACGGTAGTGTTGACTTTGGCAGGAAATGGGATCCATATAAACAGGGATTTGGAAATGTTGCAACCAACACAGATGGGA
AGAATTACTGTGGCCTACCAGGTGAATATTGGCTTGGAAATGATAAAATTAGCCAGCTTACCAGGATGGGACCCACAGAACTTTTGATAG
AAATGGAGGACTGGAAAGGAGACAAAGTAAAGGCTCACTATGGAGGATTCACTGTACAGAATGAAGCCAACAAATACCAGATCTCAGTGA
ACAAATACAGAGGAACAGCCGGTAATGCCCTCATGGATGGAGCATCTCAGCTGATGGGAGAAAACAGGACCATGACCATTCACAACGGCA
TGTTCTTCAGCACGTATGACAGAGACAATGACGGCTGGTTAACATCAGATCCCAGAAAACAGTGTTCTAAAGAAGACGGTGGTGGATGGT
GGTATAATAGATGTCATGCAGCCAATCCAAACGGCAGATACTACTGGGGTGGACAGTACACCTGGGACATGGCAAAGCATGGCACAGATG
ATGGTGTAGTATGGATGAATTGGAAGGGGTCATGGTACTCAATGAGGAAGATGAGTATGAAGATCAGGCCCTTCTTCCCACAGCAATAGT
CCCCAATACGTAGATTTTTGCTCTTCTGTATGTGACAACATTTTTGTACATTATGTTATTGGAATTTTCTTTCATACATTATATTCCTCT
AAAACTCTCAAGCAGACGTGAGTGTGACTTTTTGAAAAAAGTATAGGATAAATTACATTAAAATAGCACATGATTTTCTTTTGTTTTCTT
CATTTCTCTTGCTCACCAAGAAGTAACAAAAGTATAGTTTTGACAGAGTTGGTGTTCATAATTTCAGTTCTAGTTGATTGCGAGAATTTT
CAAATAAGGAAGAGGGGTCTTTTATCCTTGTCGTAGGAAAACCATGACGGAAAGGAAAAACTGATGTTTAAAAGTCCACTTTTAAAACTA

>5894_5894_5_ARFIP1-FGB_ARFIP1_chr4_153750878_ENST00000451320_FGB_chr4_155486960_ENST00000302068_length(amino acids)=510AA_BP=57
MSSAVGQCEFVTAAVAPRPRAAEESTMAQESPKNSAAEIPVTSNGEVDDSREHSFNRGFFSARGHRPLDKKREEAPSLRPAPPPISGGGY
RARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQ
VKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGET
SEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELL
IEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARFIP1-FGB

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ARFIP1-FGB

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner	Gene	UniProtAcc	DrugBank ID	Drug name	Drug activity	Drug type	Drug status
Tgene	FGB	P02675	DB11311	Prothrombin	Cleavage	Biotech	Approved
Tgene	FGB	P02675	DB11571	Human thrombin	Activator	Biotech	Approved
Tgene	FGB	P02675	DB11572	Thrombin alfa	Activator	Biotech	Approved
Tgene	FGB	P02675	DB11300	Thrombin	Activator	Biotech	Approved\|Investigational
Tgene	FGB	P02675	DB13151	Anti-inhibitor coagulant complex	Cleavage	Biotech	Approved\|Investigational

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Related Diseases for ARFIP1-FGB

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene		C2584774	Congenital hypofibrinogenemia	7	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0272350	Dysfibrinogenemia, Congenital	4	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene		C0001787	Osteoporosis, Age-Related	1	CTD_human
Tgene		C0029456	Osteoporosis	1	CTD_human
Tgene		C0029459	Osteoporosis, Senile	1	CTD_human
Tgene		C0030567	Parkinson Disease	1	CTD_human
Tgene		C0751406	Post-Traumatic Osteoporosis	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:ARFIP1-FGB (FusionGDB2 ID:HG27236TG2244)

Fusion Gene Summary for ARFIP1-FGB

Fusion Gene ORF analysis for ARFIP1-FGB

Fusion Genomic Features for ARFIP1-FGB

Fusion Protein Features for ARFIP1-FGB

Fusion Gene Sequence for ARFIP1-FGB

Fusion Gene PPI Analysis for ARFIP1-FGB

Related Drugs for ARFIP1-FGB

Related Diseases for ARFIP1-FGB

Fusion Gene Studies
in Kim Lab