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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GLRB-RPL13A (FusionGDB2 ID:HG2743TG23521)

Fusion Gene Summary for GLRB-RPL13A

check button Fusion gene summary
Fusion gene informationFusion gene name: GLRB-RPL13A
Fusion gene ID: hg2743tg23521
HgeneTgene
Gene symbol

GLRB

RPL13A

Gene ID

2743

23521

Gene nameglycine receptor betaribosomal protein L13a
SynonymsHKPX2L13A|TSTA1
Cytomap('GLRB')('RPL13A')

4q32.1

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionglycine receptor subunit betaglycine receptor 58 kDa subunitglycine receptor, beta subunit60S ribosomal protein L13a23 kDa highly basic proteinepididymis secretory sperm binding proteinlarge ribosomal subunit protein uL13tissue specific transplantation antigen 1
Modification date2020031320200313
UniProtAcc

P48167

.
Ensembl transtripts involved in fusion geneENST00000512619, ENST00000541722, 
ENST00000264428, ENST00000509282, 
Fusion gene scores* DoF score4 X 4 X 3=4815 X 16 X 9=2160
# samples 415
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/2160*10)=-3.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: GLRB [Title/Abstract] AND RPL13A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGLRB(158091782)-RPL13A(49994295), # samples:1
Anticipated loss of major functional domain due to fusion event.GLRB-RPL13A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GLRB-RPL13A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLRB

GO:0006811

ion transport

8717357

HgeneGLRB

GO:0007218

neuropeptide signaling pathway

8717357

TgeneRPL13A

GO:0017148

negative regulation of translation

14567916|23071094

TgeneRPL13A

GO:0071346

cellular response to interferon-gamma

15479637

TgeneRPL13A

GO:1901194

negative regulation of formation of translation preinitiation complex

17218275


check buttonFusion gene breakpoints across GLRB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RPL13A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J9-01AGLRBchr4

158091782

+RPL13Achr19

49994295

+


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Fusion Gene ORF analysis for GLRB-RPL13A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000512619ENST00000391857GLRBchr4

158091782

+RPL13Achr19

49994295

+
3UTR-3CDSENST00000541722ENST00000391857GLRBchr4

158091782

+RPL13Achr19

49994295

+
3UTR-3UTRENST00000512619ENST00000477613GLRBchr4

158091782

+RPL13Achr19

49994295

+
3UTR-3UTRENST00000541722ENST00000477613GLRBchr4

158091782

+RPL13Achr19

49994295

+
5CDS-3UTRENST00000264428ENST00000477613GLRBchr4

158091782

+RPL13Achr19

49994295

+
5CDS-3UTRENST00000509282ENST00000477613GLRBchr4

158091782

+RPL13Achr19

49994295

+
In-frameENST00000264428ENST00000391857GLRBchr4

158091782

+RPL13Achr19

49994295

+
In-frameENST00000509282ENST00000391857GLRBchr4

158091782

+RPL13Achr19

49994295

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264428GLRBchr4158091782+ENST00000391857RPL13Achr1949994295+369029271291625498
ENST00000509282GLRBchr4158091782+ENST00000391857RPL13Achr1949994295+23211558231540505

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264428ENST00000391857GLRBchr4158091782+RPL13Achr1949994295+0.0003205750.99967945
ENST00000509282ENST00000391857GLRBchr4158091782+RPL13Achr1949994295+0.0014977410.99850225

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Fusion Genomic Features for GLRB-RPL13A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for GLRB-RPL13A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:158091782/chr19:49994295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLRB

P48167

.
FUNCTION: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:8717357}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110247_2530498.0RegionStrychnine-binding
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110247_2530498.0RegionStrychnine-binding
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19247_2530304.0RegionStrychnine-binding
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+11023_2680498.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110291_2950498.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110317_3270498.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110349_4750498.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+11023_2680498.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110291_2950498.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110317_3270498.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110349_4750498.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+1923_2680304.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19291_2950304.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19317_3270304.0Topological domainExtracellular
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19349_4750304.0Topological domainCytoplasmic
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110269_2900498.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110296_3160498.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110328_3480498.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:158091782chr19:49994295ENST00000264428+110476_4960498.0TransmembraneHelical%3B Name%3D4
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110269_2900498.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110296_3160498.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110328_3480498.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:158091782chr19:49994295ENST00000509282+110476_4960498.0TransmembraneHelical%3B Name%3D4
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19269_2900304.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19296_3160304.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19328_3480304.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:158091782chr19:49994295ENST00000541722+19476_4960304.0TransmembraneHelical%3B Name%3D4


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Fusion Gene Sequence for GLRB-RPL13A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>33343_33343_1_GLRB-RPL13A_GLRB_chr4_158091782_ENST00000264428_RPL13A_chr19_49994295_ENST00000391857_length(transcript)=3690nt_BP=2927nt
CCGCCCGCGGTCGCCAGGTTCCCCCGCGGCCCGCGCTGTCCCCGCTGCGGCCCCGACCGCGGCGCGCCACGGCGCAGGCTCCGCGGCCCG
AGCAGGCGCGTCAGCCGAGCTCGGCGGTGGCGCGGGCGGCTGGGACGCAGCTGCCCCCGCTCGGCGCCCGCTGCACCCTTAGCAGCCACT
GCCACCTGGGCCCGGAGCCTCCACGATCTCGCCCGGCGATTGTGGGCAGGGGCGCCTCCGGATCGATCTTCTGAAATTCAAGTTTTCAAG
ATGAAGTTTTTATTGACAACTGCCTTTTTAATTTTAATTTCCTTGTGGGTGGAAGAAGCCTATTCTAAGGAAAAGTCTTCAAAGAAAGGG
AAGGGGAAAAAGAAGCAGTATCTATGCCCATCTCAGCAGTCAGCAGAGGACCTTGCCCGAGTACCTGCCAACTCCACTAGCAATATCTTG
AACAGGTTATTGGTCAGTTATGATCCCAGGATAAGACCAAACTTCAAAGGCATTCCTGTTGATGTAGTAGTCAACATTTTTATTAACAGT
TTTGGATCCATTCAAGAAACAACAATGGACTATAGAGTTAACATCTTCCTGAGACAAAAATGGAATGACCCCAGGCTGAAGCTCCCCAGT
GATTTTAGGGGTTCAGATGCACTGACAGTGGATCCAACAATGTACAAGTGTTTATGGAAACCTGATTTATTTTTTGCAAATGAAAAAAGT
GCCAATTTTCATGATGTGACCCAGGAAAACATCCTCCTCTTTATTTTTCGTGATGGAGATGTCCTTGTCAGCATGAGGTTATCTATTACT
CTTTCATGCCCTTTGGACTTGACATTGTTTCCCATGGATACACAACGTTGCAAGATGCAACTGGAGAGCTTTGGTTACACAACTGATGAT
TTACGATTTATCTGGCAGTCAGGAGATCCTGTGCAATTAGAAAAAATTGCCTTGCCTCAATTTGATATCAAAAAGGAAGATATTGAATAT
GGTAACTGTACAAAATACTATAAAGGCACGGGCTACTACACATGCGTGGAAGTCATCTTCACCCTGAGGAGGCAGGTCGGCTTTTACATG
ATGGGGGTCTACGCCCCAACTCTGCTCATTGTTGTTCTCTCCTGGCTTTCCTTCTGGATCAACCCGGACGCGAGTGCTGCCAGAGTGCCC
CTGGGTATCTTCTCAGTCCTCAGCTTGGCCTCTGAGTGCACAACCCTTGCCGCTGAGCTTCCCAAAGTTTCCTATGTGAAGGCTCTTGAT
GTTTGGCTTATTGCTTGCCTTCTCTTTGGGTTTGCTTCCCTGGTGGAGTATGCAGTTGTCCAGGTGATGCTGAACAACCCCAAAAGGGTT
GAAGCTGAAAAAGCCAGAATTGCTAAGGCTGAGCAAGCAGATGGAAAAGGTGGAAATGTGGCTAAAAAGAATACTGTGAATGGAACAGGG
ACTCCTGTTCATATTAGCACTTTGCAGTTCCAACAGCAGCAAAGCGAATTGATCTTTATGCAAGAGCATTGTTTCCTTTCTGCTTCTTGT
TCTTCAATGTTATATATTGGTCTATATATTTATGATAAATCTTTTCCATTTGTACAAAATAAAATTCCATTTCATTGTGACCTACTCCTT
TCATAAATGCCAATCTGTGAGAACTTTTGAATTTTCATAGCAACATTGCATTTTGGATGCCATTTGATTGTAATAAAACTGTGGCACCTT
AATTTTGAATGGCAGCATGATCATGTAATATCTGTGCTCTAATAACGATGTATATATGTATAGTGAACATATTGCTTAGTAACAAATGAA
GGACAAGCATACTACATAATATAATCCATACAATTCTCTTCAGTTAGTGTAAACTGCAAATACTACAGATAATTCTGATAATAAAATGAT
ATGCACGCTGAATCCTGCTATGGTCACCATTCTAATGTATGTAGTATTTCAAATTTCCTTCCTTGTAACTTTCAAAGAAAGCCATCTTAT
TCTTGTAAAATTTTAGATGGTATTATCACAGATTTAAAAAGGTTGTATTACATATTGTTTAAACTTTGTAAGTAGAAATATATCTGTTAT
AATTATACAGGCTCTGTGGAGAAATAAAGTTCAAAATATATTAATTTGTAAAATCAGCTCGTTTTAAAGTGTGCTTGTGTTGTCAAAAAT
ATCAGATAGTAATACACAGTGAGCATTTTTAAACAAAGGGAAACCTATATTTATGTAACTGTATACTGAATTCTGACAAAATAAAAAAAG
ATACCTTATTGACGAAATATTTAGGATAAACAAAATTCTATTTAATCCACCTTAAAACCTAAATGTATTTTCATGGATTTCATTTGTTGG
TACATATTACACAAAACATTGTGCCTTAAAATGAGTCATACATCTTTTAAATTGGAATGCAGTAATAGATATGTGATTTTACATCATTTT
TAAGAAACCAAGGGGAAGTAATAAGTTGAAAAAGAAATCCATAACTATTAAAAGATTTTAACTTTTTTATTTTATTAAAATGCTTGCATA
TTTTAAGTAAAATTAAAAATGTTTACTGAATTTATTTTTTTATTTGAATATTTTGGGATTAGTTACAAAATATTTAGAGATTAAATAAAT
AATAGCTTTGTTTGTGTTAGACTTCACTTCTACTTGTATTTTCTTTCTTGTTAAAAGTCTAGACAACTGAGATTTACTTACTTTGAACTT
GTTCCAATCCAAAAGTAAGCACTAAGTCTCATTTTATGAGACCACCATTTCTTAATATCACATCCAGTGCACCTTTGTCTTTCTGCCATA
TCTGAAATAAAACTATCAGTAATTCACATAGATAAACATAAGACTAAAGAAGTATATTTACATTATCTGGAGAGTTTTGTTGCAGCTACG
AGTTTGTATGGCAAATTCAATAATAAAGTATTGTTTATGCAAATTGCAAAAAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTC
TGAAGCCTACAAGAAAGTTTGCCTATCTGGGGCGCCTGGCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGA
AGAGGAAAGAGAAAGCCAAGATCCACTACCGGAAGAAGAAACAGCTCATGAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAAA
TTGACAAATACACAGAGGTCCTCAAGACCCACGGACTCCTGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTTGCCTGCCCTTC
CTCCATTGTTGCCCTGGAATGTACGGGACCCAGGGGCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGGGACATAGGAAGCTGGGAGCAA
GGAAAGGGTCTTAGTCACTGCCTCCCGAAGTTGCTTGAAAGCACTCGGAGAATTGTGCAGGTGTCATTTATCTATGACCAATAGGAAGAG
CAACCAGTTACTATGAGTGAAAGGGAGCCAGAAGACTGATTGGAGGGCCCTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGGT
CATATACTCTGCAGCTGTTAGAATGTGCAAGCACTTGGGGACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGAAGCAGAAATAG
ACTGGGAAGATGCACAACCAAGGGGTTACAGGCATCGCCCATGCTCCTCACCTGTATTTTGTAATCAGAAATAAATTGCTTTTAAAGAAA


>33343_33343_1_GLRB-RPL13A_GLRB_chr4_158091782_ENST00000264428_RPL13A_chr19_49994295_ENST00000391857_length(amino acids)=498AA_BP=
MGRSCPRSAPAAPLAATATWARSLHDLARRLWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQ
SAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPT
MYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQL
EKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASEC
TTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHISTLQFQQQ
QSELIFMQEHCFLSASCSSMLYIGLYIYDKSFPFVQNKIPFHCDLLLS

--------------------------------------------------------------
>33343_33343_2_GLRB-RPL13A_GLRB_chr4_158091782_ENST00000509282_RPL13A_chr19_49994295_ENST00000391857_length(transcript)=2321nt_BP=1558nt
GGGGCGGCGGAGCGCGAGGAGCACTGCGGCGTGCCCGGGAGGACGCGCGCTGCCCTGCGCGGGAGAGGGGCGCGGGGCGCCTGGCAGCGG
CAGCCGGGTCCCCGCTGCGGTGGCGCCCGCGGAGACGCTCCGGGTGGAGAGATGCAGAGGGCCGGGATCGATCTTCTGAAATTCAAGTTT
TCAAGATGAAGTTTTTATTGACAACTGCCTTTTTAATTTTAATTTCCTTGTGGGTGGAAGAAGCCTATTCTAAGGAAAAGTCTTCAAAGA
AAGGGAAGGGGAAAAAGAAGCAGTATCTATGCCCATCTCAGCAGTCAGCAGAGGACCTTGCCCGAGTACCTGCCAACTCCACTAGCAATA
TCTTGAACAGGTTATTGGTCAGTTATGATCCCAGGATAAGACCAAACTTCAAAGGCATTCCTGTTGATGTAGTAGTCAACATTTTTATTA
ACAGTTTTGGATCCATTCAAGAAACAACAATGGACTATAGAGTTAACATCTTCCTGAGACAAAAATGGAATGACCCCAGGCTGAAGCTCC
CCAGTGATTTTAGGGGTTCAGATGCACTGACAGTGGATCCAACAATGTACAAGTGTTTATGGAAACCTGATTTATTTTTTGCAAATGAAA
AAAGTGCCAATTTTCATGATGTGACCCAGGAAAACATCCTCCTCTTTATTTTTCGTGATGGAGATGTCCTTGTCAGCATGAGGTTATCTA
TTACTCTTTCATGCCCTTTGGACTTGACATTGTTTCCCATGGATACACAACGTTGCAAGATGCAACTGGAGAGCTTTGGTTACACAACTG
ATGATTTACGATTTATCTGGCAGTCAGGAGATCCTGTGCAATTAGAAAAAATTGCCTTGCCTCAATTTGATATCAAAAAGGAAGATATTG
AATATGGTAACTGTACAAAATACTATAAAGGCACGGGCTACTACACATGCGTGGAAGTCATCTTCACCCTGAGGAGGCAGGTCGGCTTTT
ACATGATGGGGGTCTACGCCCCAACTCTGCTCATTGTTGTTCTCTCCTGGCTTTCCTTCTGGATCAACCCGGACGCGAGTGCTGCCAGAG
TGCCCCTGGGTATCTTCTCAGTCCTCAGCTTGGCCTCTGAGTGCACAACCCTTGCCGCTGAGCTTCCCAAAGTTTCCTATGTGAAGGCTC
TTGATGTTTGGCTTATTGCTTGCCTTCTCTTTGGGTTTGCTTCCCTGGTGGAGTATGCAGTTGTCCAGGTGATGCTGAACAACCCCAAAA
GGGTTGAAGCTGAAAAAGCCAGAATTGCTAAGGCTGAGCAAGCAGATGGAAAAGGTGGAAATGTGGCTAAAAAGAATACTGTGAATGGAA
CAGGGACTCCTGTTCATATTAGCACTTTGCAGTTCCAACAGCAGCAAAGCGAATTGATCTTTATGCAAGAGCATTGTTTCCTTTCTGCTT
CTTGTTCTTCAATGTTATATATTGGTCTATATATTTATGATAAATCTTTTCCATTTGTACAAAATAAAATTCCATTTCATTGTGACCTAC
TCCTTTCATAAATGCCAATCTGTGAGAAAAAAAGCGGATGGTGGTTCCTGCTGCCCTCAAGGTCGTGCGTCTGAAGCCTACAAGAAAGTT
TGCCTATCTGGGGCGCCTGGCTCACGAGGTTGGCTGGAAGTACCAGGCAGTGACAGCCACCCTGGAGGAGAAGAGGAAAGAGAAAGCCAA
GATCCACTACCGGAAGAAGAAACAGCTCATGAGGCTACGGAAACAGGCCGAGAAGAACGTGGAGAAGAAAATTGACAAATACACAGAGGT
CCTCAAGACCCACGGACTCCTGGTCTGAGCCCAATAAAGACTGTTAATTCCTCATGCGTTGCCTGCCCTTCCTCCATTGTTGCCCTGGAA
TGTACGGGACCCAGGGGCAGCAGCAGTCCAGGTGCCACAGGCAGCCCTGGGACATAGGAAGCTGGGAGCAAGGAAAGGGTCTTAGTCACT
GCCTCCCGAAGTTGCTTGAAAGCACTCGGAGAATTGTGCAGGTGTCATTTATCTATGACCAATAGGAAGAGCAACCAGTTACTATGAGTG
AAAGGGAGCCAGAAGACTGATTGGAGGGCCCTATCTTGTGAGTGGGGCATCTGTTGGACTTTCCACCTGGTCATATACTCTGCAGCTGTT
AGAATGTGCAAGCACTTGGGGACAGCATGAGCTTGCTGTTGTACACAGGGTATTTCTAGAAGCAGAAATAGACTGGGAAGATGCACAACC
AAGGGGTTACAGGCATCGCCCATGCTCCTCACCTGTATTTTGTAATCAGAAATAAATTGCTTTTAAAGAAA

>33343_33343_2_GLRB-RPL13A_GLRB_chr4_158091782_ENST00000509282_RPL13A_chr19_49994295_ENST00000391857_length(amino acids)=505AA_BP=
MRRAREDARCPARERGAGRLAAAAGSPLRWRPRRRSGWRDAEGRDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQ
YLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSD
ALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQ
SGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSV
LSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNVAKKNTVNGTGTPVHIS
TLQFQQQQSELIFMQEHCFLSASCSSMLYIGLYIYDKSFPFVQNKIPFHCDLLLS

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Fusion Gene PPI Analysis for GLRB-RPL13A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GLRB-RPL13A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneGLRBP48167DB00145GlycineLigandSmall moleculeApproved|Nutraceutical|Vet_approved
HgeneGLRBP48167DB00431LindaneAntagonistSmall moleculeApproved|Withdrawn

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Related Diseases for GLRB-RPL13A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGLRBC3553291HYPEREKPLEXIA 23GENOMICS_ENGLAND;UNIPROT
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human