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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:GNB2-SNHG12 (FusionGDB2 ID:HG2783TG85028)

Fusion Gene Summary for GNB2-SNHG12

check button Fusion gene summary
Fusion gene informationFusion gene name: GNB2-SNHG12
Fusion gene ID: hg2783tg85028
HgeneTgene
Gene symbol

GNB2

SNHG12

Gene ID

2783

85028

Gene nameG protein subunit beta 2small nucleolar RNA host gene 12
Synonyms-ASLNC04080|C1orf79|LINC00100|NCRNA00100|PNAS-123
Cytomap('GNB2')('SNHG12')

7q22.1

1p35.3

Type of geneprotein-codingncRNA
Descriptionguanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2G protein, beta-2 subunitepididymis secretory sperm binding proteing protein subunit beta-2guanine nucleotide binding protein (G protein), beta polypeptide 2guanine nucleotide-binding prlong intergenic non-protein coding RNA 100small nucleolar RNA host gene 12 (non-protein coding)
Modification date2020031320200313
UniProtAcc

P62879

.
Ensembl transtripts involved in fusion geneENST00000303210, ENST00000393924, 
ENST00000393926, ENST00000424361, 
ENST00000436220, ENST00000419828, 
ENST00000427895, 
Fusion gene scores* DoF score4 X 5 X 4=805 X 3 X 3=45
# samples 55
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/45*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: GNB2 [Title/Abstract] AND SNHG12 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGNB2(100274422)-SNHG12(28906493), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8078-01AGNB2chr7

100274422

+SNHG12chr1

28906493

-
ChimerDB4STADTCGA-BR-8078GNB2chr7

100274422

+SNHG12chr1

28906493

-


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Fusion Gene ORF analysis for GNB2-SNHG12

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000303210ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000303210ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000303210ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000303210ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393924ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393924ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393924ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393924ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393926ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393926ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393926ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000393926ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000424361ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000424361ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000424361ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000424361ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000436220ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000436220ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000436220ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-5UTRENST00000436220ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000303210ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000303210ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000303210ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393924ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393924ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393924ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393926ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393926ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000393926ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000424361ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000424361ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000424361ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000436220ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000436220ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
5CDS-intronENST00000436220ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000419828ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000419828ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000419828ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000419828ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000427895ENST00000475441GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000427895ENST00000483436GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000427895ENST00000488745GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-5UTRENST00000427895ENST00000531126GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000419828ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000419828ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000419828ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000427895ENST00000384342GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000427895ENST00000384581GNB2chr7

100274422

+SNHG12chr1

28906493

-
intron-intronENST00000427895ENST00000384584GNB2chr7

100274422

+SNHG12chr1

28906493

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for GNB2-SNHG12


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)


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Fusion Protein Features for GNB2-SNHG12


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:100274422/:28906493)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GNB2

P62879

.
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for GNB2-SNHG12


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for GNB2-SNHG12


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for GNB2-SNHG12


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for GNB2-SNHG12


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource