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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:FAM102B-TRAPPC8 (FusionGDB2 ID:HG284611TG22878)

Fusion Gene Summary for FAM102B-TRAPPC8

check button Fusion gene summary
Fusion gene informationFusion gene name: FAM102B-TRAPPC8
Fusion gene ID: hg284611tg22878
HgeneTgene
Gene symbol

FAM102B

TRAPPC8

Gene ID

284611

22878

Gene namefamily with sequence similarity 102 member Btrafficking protein particle complex 8
SynonymsSYM-3BGSG1|HsT2706|KIAA1012|TRS85
Cytomap('FAM102B')('TRAPPC8')

1p13.3

18q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM102Bsym-3 homolog Btrafficking protein particle complex subunit 8general sporulation gene 1 homologprotein TRS85 homolog
Modification date2020031320200313
UniProtAcc

Q5T8I3

.
Ensembl transtripts involved in fusion geneENST00000370035, ENST00000405454, 
Fusion gene scores* DoF score4 X 4 X 4=6418 X 15 X 6=1620
# samples 418
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(18/1620*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FAM102B [Title/Abstract] AND TRAPPC8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFAM102B(109148874)-TRAPPC8(29419420), # samples:2
Anticipated loss of major functional domain due to fusion event.FAM102B-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM102B-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM102B-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FAM102B-TRAPPC8 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across FAM102B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TRAPPC8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D9-A4Z5-01AFAM102Bchr1

109148874

-TRAPPC8chr18

29419420

-
ChimerDB4SKCMTCGA-D9-A4Z5-01AFAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-


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Fusion Gene ORF analysis for FAM102B-TRAPPC8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370035ENST00000582513FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
5CDS-intronENST00000370035ENST00000584876FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
5CDS-intronENST00000405454ENST00000582513FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
5CDS-intronENST00000405454ENST00000584876FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
In-frameENST00000370035ENST00000283351FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
In-frameENST00000370035ENST00000582539FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
In-frameENST00000405454ENST00000283351FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-
In-frameENST00000405454ENST00000582539FAM102Bchr1

109148874

+TRAPPC8chr18

29419420

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000405454FAM102Bchr1109148874+ENST00000283351TRAPPC8chr1829419420-2681628581098346
ENST00000405454FAM102Bchr1109148874+ENST00000582539TRAPPC8chr1829419420-1264628581098346
ENST00000370035FAM102Bchr1109148874+ENST00000283351TRAPPC8chr1829419420-2681628581098346
ENST00000370035FAM102Bchr1109148874+ENST00000582539TRAPPC8chr1829419420-1264628581098346

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000405454ENST00000283351FAM102Bchr1109148874+TRAPPC8chr1829419420-0.0032846780.9967153
ENST00000405454ENST00000582539FAM102Bchr1109148874+TRAPPC8chr1829419420-0.0082563930.9917436
ENST00000370035ENST00000283351FAM102Bchr1109148874+TRAPPC8chr1829419420-0.0032846780.9967153
ENST00000370035ENST00000582539FAM102Bchr1109148874+TRAPPC8chr1829419420-0.0082563930.9917436

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Fusion Genomic Features for FAM102B-TRAPPC8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for FAM102B-TRAPPC8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:109148874/chr18:29419420)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FAM102B

Q5T8I3

.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM102Bchr1:109148874chr18:29419420ENST00000370035+3113_1096361.0Compositional biasNote=Poly-Lys
HgeneFAM102Bchr1:109148874chr18:29419420ENST00000405454+3113_1096356.0Compositional biasNote=Poly-Lys

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFAM102Bchr1:109148874chr18:29419420ENST00000370035+3111_14296361.0DomainC2 NT-type
HgeneFAM102Bchr1:109148874chr18:29419420ENST00000405454+3111_14296356.0DomainC2 NT-type


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Fusion Gene Sequence for FAM102B-TRAPPC8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>28299_28299_1_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000370035_TRAPPC8_chr18_29419420_ENST00000283351_length(transcript)=2681nt_BP=628nt
TCCCGACTCCCAGACGGGCGGCAGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGAGCTGAGCACCAAAAGGGCGCTCACCTCCCCGGG
CGAGCTGCAGCACGACCGCTCCCCGCGGGCGGTCGGGGTCCGCGCCGCAGCTGCCGCCGCGTTCCGGCCCAGGCTGCCGCGAGAGGCGGC
GGCAGCGGCCCCGGCCGCGGCCGGCCTGCGGCGCCCCCCGGCCGCGCCCCCGCGCACAGCTCGCGGCCCCGGCCATGGGGCTGGGCTGAT
CCGGGGCTCGGCCAAGCTGAGGCGGCGGCGCCCGGCCGTGCGCCCAGCTTGCAGGCGCCTGGCTCTCACGATGATGAAGAAGAAGAAGTT
TAAGTTTAAGGTGGACTTCGAGCTCGAGGAGCTCTCCTCAGTGCCCTTCGTCAATGGGGTCCTCTTCTGCAAGATGCGGCTGCTGGACGG
CGGCAGCTTCACCGCCGAGTCCTCCAGGGAGGTGGTACAAGCAAACTGTGTTCGCTGGAGAAAGAAGTTCTCATTTATGTGCAAAATGAG
TGCAAGTGCTGCCACAGGCATCCTAGATCCTTGTATCTACAGAGTATCCGTGAGGAAGGAATTAAAAGGTGGAAAAGCTTATGCAAAGGA
GCCACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCAT
TAAAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAA
TTGTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATG
GCTTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTA
TAACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGAT
CATCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGAT
ATACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGA
CTGAGAATACTTAACATTCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTGC
ACCTTATTAAGCCCCATCTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCTG
AGAAAGGAAAGGCCTTGTTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAATA
CAAATTTTCCTGTCTTGCTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCCC
TATGACTTATACATAACTTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCCC
TCATTCATCTCAGTATAGAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATTG
AGTTGATCTGTTTAAAATATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATAG
AATAAAGACATGCTATTCACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGGC
ATTTGGACATAAGAAATTTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAGA
AGGAGGGAAGACAGGGTGTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCATT
GACAGCTACCATGGTTTGTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTTT
CAGACTGAAGATTCCAAACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTATG
CTTCTGGATCTTAAGTGGGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACAT
TCTAAGGACACTCATTTCCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAATC
ACAGTGGTATCTCATATTTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATAA

>28299_28299_1_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000370035_TRAPPC8_chr18_29419420_ENST00000283351_length(amino acids)=346AA_BP=190
MSTKRALTSPGELQHDRSPRAVGVRAAAAAAFRPRLPREAAAAAPAAAGLRRPPAAPPRTARGPGHGAGLIRGSAKLRRRRPAVRPACRR
LALTMMKKKKFKFKVDFELEELSSVPFVNGVLFCKMRLLDGGSFTAESSREVVQANCVRWRKKFSFMCKMSASAATGILDPCIYRVSVRK
ELKGGKAYAKEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSP

--------------------------------------------------------------
>28299_28299_2_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000370035_TRAPPC8_chr18_29419420_ENST00000582539_length(transcript)=1264nt_BP=628nt
TCCCGACTCCCAGACGGGCGGCAGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGAGCTGAGCACCAAAAGGGCGCTCACCTCCCCGGG
CGAGCTGCAGCACGACCGCTCCCCGCGGGCGGTCGGGGTCCGCGCCGCAGCTGCCGCCGCGTTCCGGCCCAGGCTGCCGCGAGAGGCGGC
GGCAGCGGCCCCGGCCGCGGCCGGCCTGCGGCGCCCCCCGGCCGCGCCCCCGCGCACAGCTCGCGGCCCCGGCCATGGGGCTGGGCTGAT
CCGGGGCTCGGCCAAGCTGAGGCGGCGGCGCCCGGCCGTGCGCCCAGCTTGCAGGCGCCTGGCTCTCACGATGATGAAGAAGAAGAAGTT
TAAGTTTAAGGTGGACTTCGAGCTCGAGGAGCTCTCCTCAGTGCCCTTCGTCAATGGGGTCCTCTTCTGCAAGATGCGGCTGCTGGACGG
CGGCAGCTTCACCGCCGAGTCCTCCAGGGAGGTGGTACAAGCAAACTGTGTTCGCTGGAGAAAGAAGTTCTCATTTATGTGCAAAATGAG
TGCAAGTGCTGCCACAGGCATCCTAGATCCTTGTATCTACAGAGTATCCGTGAGGAAGGAATTAAAAGGTGGAAAAGCTTATGCAAAGGA
GCCACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCAT
TAAAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAA
TTGTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATG
GCTTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTA
TAACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGAT
CATCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGAT
ATACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGA

>28299_28299_2_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000370035_TRAPPC8_chr18_29419420_ENST00000582539_length(amino acids)=346AA_BP=190
MSTKRALTSPGELQHDRSPRAVGVRAAAAAAFRPRLPREAAAAAPAAAGLRRPPAAPPRTARGPGHGAGLIRGSAKLRRRRPAVRPACRR
LALTMMKKKKFKFKVDFELEELSSVPFVNGVLFCKMRLLDGGSFTAESSREVVQANCVRWRKKFSFMCKMSASAATGILDPCIYRVSVRK
ELKGGKAYAKEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSP

--------------------------------------------------------------
>28299_28299_3_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000405454_TRAPPC8_chr18_29419420_ENST00000283351_length(transcript)=2681nt_BP=628nt
TCCCGACTCCCAGACGGGCGGCAGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGAGCTGAGCACCAAAAGGGCGCTCACCTCCCCGGG
CGAGCTGCAGCACGACCGCTCCCCGCGGGCGGTCGGGGTCCGCGCCGCAGCTGCCGCCGCGTTCCGGCCCAGGCTGCCGCGAGAGGCGGC
GGCAGCGGCCCCGGCCGCGGCCGGCCTGCGGCGCCCCCCGGCCGCGCCCCCGCGCACAGCTCGCGGCCCCGGCCATGGGGCTGGGCTGAT
CCGGGGCTCGGCCAAGCTGAGGCGGCGGCGCCCGGCCGTGCGCCCAGCTTGCAGGCGCCTGGCTCTCACGATGATGAAGAAGAAGAAGTT
TAAGTTTAAGGTGGACTTCGAGCTCGAGGAGCTCTCCTCAGTGCCCTTCGTCAATGGGGTCCTCTTCTGCAAGATGCGGCTGCTGGACGG
CGGCAGCTTCACCGCCGAGTCCTCCAGGGAGGTGGTACAAGCAAACTGTGTTCGCTGGAGAAAGAAGTTCTCATTTATGTGCAAAATGAG
TGCAAGTGCTGCCACAGGCATCCTAGATCCTTGTATCTACAGAGTATCCGTGAGGAAGGAATTAAAAGGTGGAAAAGCTTATGCAAAGGA
GCCACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCAT
TAAAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAA
TTGTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATG
GCTTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTA
TAACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGAT
CATCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGAT
ATACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGA
CTGAGAATACTTAACATTCTTTTTCTGTATTTCTTTAAACCCTGAGAATAATTTACATGCTCATAATACAGGATATCAGCATATTTGTGC
ACCTTATTAAGCCCCATCTTAAGAAAACACAAAGTCTAAGTCTGCTGTTACAACTTGTCAATGGTATACGAATATTAGGAGATGATTCTG
AGAAAGGAAAGGCCTTGTTGGCAGTACTCCTGTTAAGCCATTAGTCTCTAAATTCCAGCTTTACTGTGAAGTTCTATAGAGTGTTAAATA
CAAATTTTCCTGTCTTGCTTCACACAGTTCCTTAAAATCAGTTTTGAACTTTGGTCATAGAGTCTTCATATTTCAGTATTTGGTGGTCCC
TATGACTTATACATAACTTTGTAAAAAGAAAAAAAAATTTTTTCTGATGCTTTGAATATAGTTTTGAAAGGAGTTTTGACTTTTTTCCCC
TCATTCATCTCAGTATAGAGTGCGCTATTTCACAATACGATTTTTGTCATTAAAATTACCATATTCTTTATTATATAACGTTAACTATTG
AGTTGATCTGTTTAAAATATAAATCTCAAGTTAATTAAAAATAAGCTTTTCAAAAATGTATTATATTTATAACAAATATACTGTAAATAG
AATAAAGACATGCTATTCACTGTATAGCGTATTAGTATCTGTTGATTAGAAAGTCTGGTTTCAAAATATTTTTTTATTCAGAGAATGGGC
ATTTGGACATAAGAAATTTCAATTCAGCCCTGCTGCAGATAGAGAAATGGGAGCAAGGTTGTTTCAATGAATATCTCTTGTCATTGGAGA
AGGAGGGAAGACAGGGTGTAGGAGTGGGTGGCAGGGAGTACAAGAGCCAGGGTCAGTCAAGTCTGGAGCAGATGGGGTCCTTGTGCCATT
GACAGCTACCATGGTTTGTTCCAGTCTCAATCTCGGCACTAATCGGAGCAGACTGCACCAAAGTGGGGAGAGATCAAAAGACCCCGTTTT
CAGACTGAAGATTCCAAACCTGTACTTGGAACAACTCTTCTTGAGAGATGGGTGGCTAGTCTGTGTGCCTCTCTGCAACTGCTGCTTATG
CTTCTGGATCTTAAGTGGGTCTCTGGCTTTTCAGCTCCTTCCACTCTGTGTCTTAGCAGGTGTGGGACAAGTTGGAGAGGAAGGTCACAT
TCTAAGGACACTCATTTCCTTCTTGAGAGTTTAGGGCCATGGGCTTATAAAAAGTCTGAGGAGGAAAGACAAGAATGAGGAGGCATAATC
ACAGTGGTATCTCATATTTAAACCACTCAGCTGAATATTAAATTGAACCGATTGTTAAACAGACACTAATAAAAAAATTAAACTATATAA

>28299_28299_3_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000405454_TRAPPC8_chr18_29419420_ENST00000283351_length(amino acids)=346AA_BP=190
MSTKRALTSPGELQHDRSPRAVGVRAAAAAAFRPRLPREAAAAAPAAAGLRRPPAAPPRTARGPGHGAGLIRGSAKLRRRRPAVRPACRR
LALTMMKKKKFKFKVDFELEELSSVPFVNGVLFCKMRLLDGGSFTAESSREVVQANCVRWRKKFSFMCKMSASAATGILDPCIYRVSVRK
ELKGGKAYAKEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSP

--------------------------------------------------------------
>28299_28299_4_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000405454_TRAPPC8_chr18_29419420_ENST00000582539_length(transcript)=1264nt_BP=628nt
TCCCGACTCCCAGACGGGCGGCAGCGGCGGCGGAGGCGGCGGCGGCGGCGGCGGCGAGCTGAGCACCAAAAGGGCGCTCACCTCCCCGGG
CGAGCTGCAGCACGACCGCTCCCCGCGGGCGGTCGGGGTCCGCGCCGCAGCTGCCGCCGCGTTCCGGCCCAGGCTGCCGCGAGAGGCGGC
GGCAGCGGCCCCGGCCGCGGCCGGCCTGCGGCGCCCCCCGGCCGCGCCCCCGCGCACAGCTCGCGGCCCCGGCCATGGGGCTGGGCTGAT
CCGGGGCTCGGCCAAGCTGAGGCGGCGGCGCCCGGCCGTGCGCCCAGCTTGCAGGCGCCTGGCTCTCACGATGATGAAGAAGAAGAAGTT
TAAGTTTAAGGTGGACTTCGAGCTCGAGGAGCTCTCCTCAGTGCCCTTCGTCAATGGGGTCCTCTTCTGCAAGATGCGGCTGCTGGACGG
CGGCAGCTTCACCGCCGAGTCCTCCAGGGAGGTGGTACAAGCAAACTGTGTTCGCTGGAGAAAGAAGTTCTCATTTATGTGCAAAATGAG
TGCAAGTGCTGCCACAGGCATCCTAGATCCTTGTATCTACAGAGTATCCGTGAGGAAGGAATTAAAAGGTGGAAAAGCTTATGCAAAGGA
GCCACCAGAAATGGAACTATTGAAATTTTTCAGGCCAGAAAACATTACAGTTTCCTCAAGGCCATCAGTAGAGCAGCTTTCTAGTCTCAT
TAAAACGAGTCTTCACTACCCAGAATCATTTAATCATCCATTTCATCAAAAAAGCCTTTGTTTAGTACCAGTCACTCTTTTACTTTCCAA
TTGTTCTAAGGCTGATGTAGATGTCATAGTTGATCTTCGGCATAAAACAACAAGTCCAGAAGCACTGGAAATCCATGGATCATTCACATG
GCTTGGACAAACACAGTATAAACTTCAACTTAAAAGCCAGGAGATTCACAGTCTGCAGCTGAAAGCATGCTTTGTTCATACAGGTGTTTA
TAACCTTGGAACTCCTAGGGTATTTGCCAAGTTATCGGACCAAGTTACAGTGTTTGAAACAAGTCAGCAGAATTCCATGCCTGCCCTGAT
CATCATCAGTAATGTGTGACAACTTGGAAATTTGTACTGAAATCCACAATAATCAGTTTTTGCTGGATGGGTTTTACAGCAGTATTTGAT
ATACCTAACTTGTTATGGAGGTTGATTGATATCTGATCCCTGCAAAATACTTTGACTTGTCATTTTGTTGATGATGCAAAGCACGTTGGA

>28299_28299_4_FAM102B-TRAPPC8_FAM102B_chr1_109148874_ENST00000405454_TRAPPC8_chr18_29419420_ENST00000582539_length(amino acids)=346AA_BP=190
MSTKRALTSPGELQHDRSPRAVGVRAAAAAAFRPRLPREAAAAAPAAAGLRRPPAAPPRTARGPGHGAGLIRGSAKLRRRRPAVRPACRR
LALTMMKKKKFKFKVDFELEELSSVPFVNGVLFCKMRLLDGGSFTAESSREVVQANCVRWRKKFSFMCKMSASAATGILDPCIYRVSVRK
ELKGGKAYAKEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSP

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Fusion Gene PPI Analysis for FAM102B-TRAPPC8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FAM102B-TRAPPC8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FAM102B-TRAPPC8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFAM102BC0023893Liver Cirrhosis, Experimental1CTD_human