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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:DTWD2-AFF4 (FusionGDB2 ID:HG285605TG27125) |
Fusion Gene Summary for DTWD2-AFF4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: DTWD2-AFF4 | Fusion gene ID: hg285605tg27125 | Hgene | Tgene | Gene symbol | DTWD2 | AFF4 | Gene ID | 285605 | 27125 |
| Gene name | DTW domain containing 2 | AF4/FMR2 family member 4 | |
| Synonyms | - | AF5Q31|CHOPS|MCEF | |
| Cytomap | ('DTWD2')('AFF4') 5q23.1 | 5q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | DTW domain-containing protein 2 | AF4/FMR2 family member 4ALL1-fused gene from chromosome 5q31 proteinmajor CDK9 elongation factor-associated protein | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q8NBA8 | Q9UHB7 | |
| Ensembl transtripts involved in fusion gene | ENST00000304058, ENST00000510708, ENST00000515439, | ENST00000304058, ENST00000510708, ENST00000515439, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 8 X 9 X 3=216 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/216*10)=-1.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: DTWD2 [Title/Abstract] AND AFF4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | DTWD2(118264232)-AFF4(132234833), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | DTWD2-AFF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DTWD2-AFF4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DTWD2-AFF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DTWD2-AFF4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across DTWD2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across AFF4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-CH-5744-01A | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
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Fusion Gene ORF analysis for DTWD2-AFF4 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000304058 | ENST00000491831 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| 5CDS-intron | ENST00000510708 | ENST00000491831 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| In-frame | ENST00000304058 | ENST00000265343 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| In-frame | ENST00000304058 | ENST00000378595 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| In-frame | ENST00000510708 | ENST00000265343 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| In-frame | ENST00000510708 | ENST00000378595 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| intron-3CDS | ENST00000515439 | ENST00000265343 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| intron-3CDS | ENST00000515439 | ENST00000378595 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| intron-intron | ENST00000515439 | ENST00000491831 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000304058 | DTWD2 | chr5 | 118264232 | - | ENST00000265343 | AFF4 | chr5 | 132234833 | - | 8454 | 470 | 56 | 2773 | 905 |
| ENST00000304058 | DTWD2 | chr5 | 118264232 | - | ENST00000378595 | AFF4 | chr5 | 132234833 | - | 2266 | 470 | 56 | 1984 | 642 |
| ENST00000510708 | DTWD2 | chr5 | 118264232 | - | ENST00000265343 | AFF4 | chr5 | 132234833 | - | 8615 | 631 | 16 | 2934 | 972 |
| ENST00000510708 | DTWD2 | chr5 | 118264232 | - | ENST00000378595 | AFF4 | chr5 | 132234833 | - | 2427 | 631 | 16 | 2145 | 709 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000304058 | ENST00000265343 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - | 0.00021778 | 0.99978226 |
| ENST00000304058 | ENST00000378595 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - | 0.003665838 | 0.9963342 |
| ENST00000510708 | ENST00000265343 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - | 0.000275249 | 0.9997247 |
| ENST00000510708 | ENST00000378595 | DTWD2 | chr5 | 118264232 | - | AFF4 | chr5 | 132234833 | - | 0.009044564 | 0.9909554 |
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Fusion Genomic Features for DTWD2-AFF4 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for DTWD2-AFF4 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:118264232/chr5:132234833) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| DTWD2 | AFF4 |
| FUNCTION: Catalyzes the formation of 3-(3-amino-3-carboxypropyl)uridine (acp3U) at position 20a in the D-loop of several cytoplasmic tRNAs (acp3U(20a)) (PubMed:31804502). Also has a weak activity to form acp3U at position 20 in the D-loop of tRNAs (acp3U(20)) (PubMed:31804502). {ECO:0000269|PubMed:31804502}. | FUNCTION: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:23251033}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | DTWD2 | chr5:118264232 | chr5:132234833 | ENST00000510708 | - | 4 | 6 | 178_181 | 199 | 299.0 | Motif | Note=DXTW |
| Tgene | AFF4 | chr5:118264232 | chr5:132234833 | ENST00000265343 | 7 | 21 | 836_899 | 396 | 1164.0 | Compositional bias | Note=Ser-rich | |
| Tgene | AFF4 | chr5:118264232 | chr5:132234833 | ENST00000378595 | 7 | 13 | 836_899 | 396 | 901.0 | Compositional bias | Note=Ser-rich |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | AFF4 | chr5:118264232 | chr5:132234833 | ENST00000265343 | 7 | 21 | 102_461 | 396 | 1164.0 | Compositional bias | Note=Ser-rich | |
| Tgene | AFF4 | chr5:118264232 | chr5:132234833 | ENST00000378595 | 7 | 13 | 102_461 | 396 | 901.0 | Compositional bias | Note=Ser-rich |
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Fusion Gene Sequence for DTWD2-AFF4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >24394_24394_1_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000304058_AFF4_chr5_132234833_ENST00000265343_length(transcript)=8454nt_BP=470nt GGAGTCGGCGGCTCGGGCAGCTCTGCGATTAGGGCGGCGGAGTTGGCGGGTGCACGTTGGAAATCTCGGAAATGCCAGGCACAGCTACCT ACCGGCCTCAGAAAGTGTGTTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAG AGGAAAACAAAGTGTTGCGTACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTG AAGAAAGAGATCCTGAACTTTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAAT TTATATTAGATTCTCCTGTTTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCT TGTTCCGACATCCCAAACAGGATTGTGATAAGACAATGCCGAGGAGTACACCAGGAAGTAACTCTGAACCTTCACACCATAATAGTGAAG GAGCAGATAACTCCAGGGATGATTCTAGTAGCCACAGTGGATCTGAAAGCAGCTCTGGATCTGACTCAGAGAGTGAAAGTAGTTCCAGTG ACAGTGAGGCAAATGAGCCATCCCAGAGTGCATCTCCCGAGCCTGAACCCCCGCCAACAAACAAATGGCAACTTGATAATTGGCTGAATA AAGTGAACCCACATAAAGTGTCACCCGCCTCTTCAGTGGACAGTAACATCCCATCATCTCAAGGCTACAAAAAGGAAGGCCGAGAGCAGG GCACTGGGAATAGCTACACTGATACAAGTGGACCTAAAGAAACGAGTTCCGCTACTCCGGGACGAGACTCCAAAACCATCCAAAAGGGAT CAGAAAGTGGGCGTGGGAGGCAGAAATCTCCTGCACAGAGTGACAGCACAACACAGAGAAGAACTGTAGGCAAAAAACAACCCAAAAAGG CTGAGAAGGCAGCTGCTGAAGAGCCTCGTGGAGGCCTGAAGATAGAAAGTGAAACCCCTGTAGACTTGGCTAGCAGCATGCCCTCCAGCA GACACAAAGCAGCCACCAAAGGCTCAAGGAAACCCAATATAAAGAAGGAGTCTAAGTCTTCCCCTCGACCTACAGCAGAGAAAAAGAAAT ATAAGTCAACAAGTAAATCTTCCCAGAAATCAAGGGAAATCATAGAAACAGATACCTCATCCTCAGATTCAGATGAAAGTGAGAGCCTTC CTCCTTCCTCACAAACTCCTAAGTACCCCGAGAGCAATAGGACTCCTGTTAAACCCTCCTCAGTGGAGGAAGAAGATAGCTTTTTTCGGC AACGAATGTTCTCTCCTATGGAAGAGAAGGAACTTCTTTCACCCCTCAGTGAGCCTGATGACAGGTACCCACTTATTGTGAAGATTGACC TGAATCTTTTGACTAGAATACCAGGAAAGCCTTACAAAGAAACAGAGCCGCCCAAGGGGGAAAAGAAAAATGTGCCAGAAAAGCACACGA GAGAGGCTCAGAAACAAGCCTCAGAAAAAGTTTCCAACAAAGGCAAGAGGAAGCATAAGAATGAAGATGATAACCGAGCCAGTGAGAGCA AGAAACCCAAAACGGAGGACAAGAATTCAGCAGGCCATAAGCCATCCAGCAACAGAGAGTCATCTAAGCAGAGTGCTGCAAAAGAAAAGG ATTTGTTGCCTTCTCCCGCTGGGCCTGTTCCTTCAAAAGATCCAAAAACAGAGCATGGCTCTCGGAAGAGGACTATTAGTCAGTCTTCTT CCTTAAAGTCAAGCAGTAACAGCAACAAGGAGACGAGTGGCAGCAGCAAAAACAGTTCCTCCACATCAAAGCAGAAGAAGACCGAAGGGA AGACTTCCAGTAGCTCCAAGGAGGTTAAGGAAAAGGCTCCAAGTAGCTCCTCTAACTGTCCTCCATCTGCACCAACTCTTGATTCTTCTA AGCCTCGGAGAACAAAGCTTGTCTTTGATGACAGAAATTATTCAGCAGACCATTATTTACAAGAAGCAAAAAAGCTAAAGCACAATGCAG ATGCATTGTCTGATAGGTTTGAGAAAGCTGTATACTATCTTGATGCTGTGGTATCTTTCATTGAATGTGGGAATGCATTAGAGAAGAATG CTCAGGAATCCAAATCCCCATTCCCTATGTATTCAGAGACGGTGGATCTCATCAAATACACTATGAAGCTAAAGAATTACTTGGCACCAG ATGCTACAGCTGCAGATAAACGACTCACAGTACTTTGCCTGCGATGCGAGTCTTTGCTGTACCTGAGGCTGTTCAAACTGAAGAAGGAAA ATGCTCTGAAGTACTCAAAGACACTGACAGAGCACCTGAAGAATTCTTATAATAATTCTCAAGCACCATCGCCTGGCTTGGGAAGCAAAG CTGTGGGGATGCCTTCCCCTGTTTCTCCAAAGCTGTCACCAGGCAATTCAGGAAATTATTCATCTGGGGCCAGTAGTGCTTCTGCAAGTG GTTCTTCAGTGACCATTCCACAGAAGATCCACCAGATGGCAGCCAGCTATGTTCAGGTCACATCCAACTTCCTCTATGCCACCGAAATTT GGGACCAAGCTGAACAGCTTTCCAAAGAGCAAAAAGAATTCTTTGCTGAACTGGATAAAGTAATGGGCCCTCTCATCTTTAATGCAAGCA TCATGACAGATCTAGTTCGTTATACCCGGCAGGGACTGCACTGGCTTCGCCAGGATGCCAAGTTGATATCTTGAACTGAACACATTCTCG TTGCCTCTGATTTTCTCCACAACACTGTGTCACATCACGAAGGAAAACTGCCATAACATACCACCTAGTCGACACTAAGAATGAGGAATA GTTTTCTCCTCGTTGGTTCATGTGTTGTTGTTTTTGATAATCCAAAGCGATCATGTCAGTTGGCCCTTTAATATTTCCAATGTGAAAGAT TATTTAAATGCTTTTAAATCTGCAGCACATTGATAAGATGGTTTCCGTGAGCTATGATAAGATTGAAATTCCAGTTGCAATTCATAACTA ATGAATTGAAATTTTATTTATTTTAATTTTTTTAAGTTCCCAGATTGGGGCTAGTTTAAGACTTAGTTATTTCTGCCTATAAATTTACTC TGTTGAATATTTAGCATAAATTTAATGTAGACATTTTTATTTATATACCTTGGGAGCTTTATTACCTAATATCTTTTTGTGGTAGCTGTT CTAAGAGTAAGAATTGGTTCGTCTAAAATAAGGACATATTCTTTCTACACCTGCTACCTGACCTGATATTTGAAATCTTAACTCCAATTT TATTATTGTGGAATTTACAGTTAGTATTAAGGATATTCTTCTACACATGAAAAAATCACTTAAATATGAGAAAATGGCATTCTACATGTA TGTACTATGAAATGTGTCTGATTTGGTATGCATTATTTCAAAAACTGTGAATGTGTGTTAATAACACTACAGCAATCACACAGTGACTAT AGCTTGCATTTAATGCATTACAAAAGAGGGAGGACAAACTTTCTAGAAGAAGCATTTCATGTTGAAGGGTTTCATAAAAGGACAATCCTG AACGTTACGGATTTTATTAAAACCATATGTTATTTTTTGTTGCTAATCATTTGACACTTAATCGAAACAGAATAAGTTACTGTGGAAAAA AGGATGATCCAACTCCTGAGGATTGCCGCCTGTGTGTCTTTAATTGATTATCTTTGATAGTTAGAGTTATTTTTCAGATTTTTCCCCCTC ATACTGGATTGTGATGCTCTGATATGAGCATGCAATGACTGATACAGAAATAGGCTGGAGCTTCGGTGTGTGCTTTTGCTATACAGCTTA CAGTTCTAATGCCTGATGTAGAGATGATGAATTTCTCCTTTTTAAACCTATCTTCTGTTTACTCCTTTTGCATTATGAAGGCCCTCTTCA ATGATGTATGTTTCTGATGGAATCAGAAAATTTCACACTAGAAAAGTGTACCTAACTTGATTCAGTGTGAGCTCTTGGGACAGGGAGTGG AGCCAGGGGTAGAGCTTAAAGAAGCTGGCTCTGTAAGAGTTGTATATCAAAGTACCTTTTGCTACAAGGTGCATATAGAAGTCTAAGATA AGAAATGTACCCTCTATACTTTATTTTTCATGCCCCTATCATGTTTGGTGTGCCTTAAATCTTACCTTTAAATGAAGACTCTATGGATTG TTTACAAATGAAGTTTTACACTAGGACCAGATCGTCCATACATGATTGGTCTTCTACAATAATAATGTTCAATTCTTTCATTTTAAATCT TTCTTTAGGGTCATATAAAGATTAGTTCTTTCAGAAAAGCTATTGCTTTGGTACATGACTTAGTCTAACCAGTTGGGTAATGCTGCTTTG AAAAATAGTTTGTCCCTCTCCCCATTCCAAAAATGAATCCATTCAGTCAGAAAAAAAGATTATCCTACTATTTGTAGATGATTGCTAAGG CTTGAAATAGGAAAGGGGAAAGAAGGGATAGAAAAGTTTCAAGTCCAGTAGTGCAGTGAATCCTTTGTGTTTGAGACTTTTTTACACTTA TTTCTGAAGTTAGTGAACTTTCATTGTCCCTGTGGCCTCATATTTATAGAGCTTCTTAACTGTTTTGTACCTCAGATTGTTTTTAGATGT CATTGAAGATTGAGATGTACAAATTATGTTGAATTTAACCTGTTTCTCTTGGAGAAATTGCCTCTGATATCTTTCTAACTTAATCTTAGT GTGTTCTAGGAACAGTTTTCCATAAGAGGACAACTTCTCAATGATCATGATAGTTATTTAGTAAGAAATAATGGTTGTTAATCAAATACA TGTTATGTCTTGTCCTTCTCTGATTTTTCTGACTTGGATTCCTTAATTTGCAGTGATGTCTTAGAAATGGAAAAAGTATCCTCTGGGCTT TCAGACTTTCAGCAACAACAGCCAGTGGGATACCTCTGAGTTCTTGTGTTCTAGTCTCTTGTATGTCCTGAAAGGCAGCAGGAGCATTTT TGGGGTCACACTGATATTTTGTTAAAGCAGAGTTTCCTGCATGGTTTATGGTGCTGCTCTAATATTTTCTCTTTAAAACTGTGTCAATTT TTGGAGAATGAATTTTTCAACCTTTTCATTGTGGAGGATTTTTCCCACAAGGTAGTAATGGGCAATGGATCAAAATCCTATCATAAATGA TTGAATTTTCAATGTCATAGTGTGTGGAAATACTACTCCCTTTCCTCCATGTCTATCTTCTTAGATGTTCTGTCTTTGTCATCATCTGCT CCAGCACATACTTTGGACTCCTTTACAGGTGACCTTCCCCCCTCCCTCCTCAATAGGTGTCCTCAGTGTTTTCTAAGCATTTAAAACTGA ATTTGACAAGTGGCTAAAAACTTAGTCTGAGACTTGTACTTAGTATATGGTTAATTATAGAAACAACAACTATTTTAAACAGTTACTCTG TTGACTGCTCTTTATGACTACACTTGTATGCCAGGAGGCAGCAGCCTATACACCATTAGACTCTTTACAAGCAACCAACGAACCAATTGC AGTGGTTGCAGTTGTCACAGTAGTCTTGCCTGGGCCAGACTGGGCTGGGCTGTGGGAAGCATTCCCCTTCAGGGGAGTTTCCACAGCTCA GCCCAGGCTCCAGTCTGGCTAGAGAGCATCCAGCCCATTCCTTGCCTCAGTGCCACCTTTTTCTGGGCAAGTAGCCAAGAAGTGACTTTA TATGCAGTGAGTACTTCAGATAAACTTACAGCTACAGCTGCCGAAGAGTGGAGAAGGTTGACCACCATTTATTTAATTCTCTAGTGTAAA AACAATTGAGAGCAGTGTGCGTGAGCCCACAGACACCTGTGTTTCTGGGAGCTCTGGCAGTGGCGGATTCATAGGCACTTGGGCTGCACT TTGAATGACACACTTGGCTTTATTAGATTCACTAGTTTTTAAAAAATTGTTGTTCGTTTCTTTTCATTAAAGGTTTAATCAGACAGATCA GACAGCATAATTTTGTATTTAATGACAGAAACGTTGGTACATTTCTTCATGAATGAGCTTGCATTCTGAAGCAAGAGCCTACAAAAGGCA CTTGTTATAAATGAAAGTTCTGGCTCTAGAGGCCAGTACTCTGGAGTTTCAGAGCAGCCAGTGATTGTTCCAGTCAGTGATGCCTAGTTA TATAGAGGAGGAGTACACTGTGCACTCTTCTAGGTGTAAGGGTATGCAACTTTGGATCTTAAAATTCTGTACACATACACACTTTATATA TATGTATGTATGTATGAAAACATGAAATTAGTTTGTCAAATATGTGTGTGTTTAGTATTTTAGCTTAGTGCAACTATTTCCACATTATTT ATTAAATTGATCTAAGACACTTTCTTGTTGACACCTTGAATATTAATGTTCAAGGGTGCAATGTGTATTCCTTTAGATTGTTAAAGCTTA ATTACTATGATTTGTAGTAAATTAACTTTTAAAATGTATTTGAGCCCTTCTGTAGTGTCGTAGGGCTCTTACAGGGTGGGAAAGATTTTA ATTTTCCAGTTGCTAATTGAACAGTATGGCCTCATTATATATTTTGATTTATAGGAGTTTGTGTCTGGGTCCCAGGAACATCTACTGGGG ATGACTGTTAGGCAGCTTGTGATGATGTTTTTTAAAAAACCTAAGTAACTTGGGGAGACAGAGCATTTCAAACCCATATAGACACCTATC ATACCTGTATATCCCCTAATACATGGAACATAAATTTCATTTCAGCTTTATGCATTAATGTATTGAAGAGGCAGGCTTTTTTTCCAGTAA TAATACTGTACATCTAAGGTTGCTATTCAGTAAAACTAATAGAAGAGATAATTATTGAATACCTTGGAATATGTAGTGAGAAGAGGCCAA ATTTTTCATGTTTGTGAGCATGTCTTTCAGATACTCGCTAATGGAGAAATTCACTTTAGACCTCTAGACCCCAAAACCAAGTTAGCAAGT GACAAAAAGTAAATTATTAATAGTCTGTAAAGTGGATGCTGGTCTTACAAAGCTCCTATTCACATGAACCCTATGGTTAATTAGAAAGAA CTTGCTGTCTCCAGAAAAGGGAATGGAAATAATAACTATGTATCTTCTTTTCATGTAATTTGGTCACAGAATAAGGTATTCAAGTTAAGT CTAATCCAAGTCTTAGAGATCTTTAAGTATCCTAAAATAGCAGCCTAAGTAGTCATCATGTAAAGAAGTTGACTTTCAGGAATGTCAGCA TTGACCTCTCCTTGCCACTGTTACTCAGCTAAACATAACTTGCCATTCTTAAAAATAAAAAAGCTCCCACCCAGAAACTCTAGTGATACT CAGTTTTGACCTCTTACTGCTTCCATGTGGGACTTCTTTTCAGCTTTTAACCATTGGAATTTTCTACCTGCTATGTTCCTCTCTGGAAAA TATCAATTTGGAAATGCTGCCTTTCAAATCAATGCCATGATCATCCATATTGTTGAGTTTGTTGTTGGTGTTCCAGAAGTGTCCCCATTT TACAACTTTATGCACACACCTGGCAAATCATTAACATGAGCATTCAACAGTACTGGGATGGGTGGGGTGGGGGTAGGGGGCTCACCAACA GAACTGGCCAGTTGACATTGCCTGAAAAGGCACCACCTTTAAGGGCCAGTTGTGGGGTTGGTAAGCACAGTTATGAAAATTTCTATCTAG CCTCCGTTTTGAATGGTTTTAAGAAATTTTGTATATGGAGGATGGAAATGCTTATATATTTATTGAAAATCCTTTTATTTGAAATTAAAA TTATTTGGTATATAATTGTTTGATATTTGGGGAGGGTTTTGGAGGGGAGATAATGTCACTGATAAATTAAAAGCCTGTTGATTTTGCAGA AAGGTACTGTTAGTGACTGATAAGGATGCCTTTGTTTTGTACATGAACCAAATCTTTGTTTTACATTTCTTTTATCCAAAATATTTAGGC ATCTGACATTTTCAACCAGAATTTCAATTATATACTGTGATTTTTATTTGTTGCAATACATTACAATTTCAGAGGTACTTTGGGGCTCAA AAGCTAGGATTTCTAAGTCAGTATGTGCATTTCACACGATAAAGCTGTTAATGGTGAGCAAAGTATTATATACTAACTAGATTTTTCCAC ATCTGTATAGTATATTATATGTATTTTGTGGTATTGAGAGTATAGAAAGTTTAGAGTGTCAAACATGCGTTTAATGTGTATTTTTAAACA AATTTATGGCAATTAAAATATTTGGAGACAAGGGTATCACATTTCAATTTGTAAAGATCTTTTTAACTCTACTGTGTCATTAAGATGCTT TGTACAATGCCAAACCATAGTTGGAGAAACTAAGTTTAATAAATATCAAATAGATTTTCTGTATTAAAGTTACTGAACACTGTA >24394_24394_1_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000304058_AFF4_chr5_132234833_ENST00000265343_length(amino acids)=905AA_BP=138 MEISEMPGTATYRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLIL YPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSS GSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSAT PGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESK SSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEP DDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNR ESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSN CPPSAPTLDSSKPRRTKLVFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIK YTMKLKNYLAPDATAADKRLTVLCLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGN YSSGASSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQGLHWLRQD AKLIS -------------------------------------------------------------- >24394_24394_2_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000304058_AFF4_chr5_132234833_ENST00000378595_length(transcript)=2266nt_BP=470nt GGAGTCGGCGGCTCGGGCAGCTCTGCGATTAGGGCGGCGGAGTTGGCGGGTGCACGTTGGAAATCTCGGAAATGCCAGGCACAGCTACCT ACCGGCCTCAGAAAGTGTGTTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAG AGGAAAACAAAGTGTTGCGTACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTG AAGAAAGAGATCCTGAACTTTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAAT TTATATTAGATTCTCCTGTTTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCT TGTTCCGACATCCCAAACAGGATTGTGATAAGACAATGCCGAGGAGTACACCAGGAAGTAACTCTGAACCTTCACACCATAATAGTGAAG GAGCAGATAACTCCAGGGATGATTCTAGTAGCCACAGTGGATCTGAAAGCAGCTCTGGATCTGACTCAGAGAGTGAAAGTAGTTCCAGTG ACAGTGAGGCAAATGAGCCATCCCAGAGTGCATCTCCCGAGCCTGAACCCCCGCCAACAAACAAATGGCAACTTGATAATTGGCTGAATA AAGTGAACCCACATAAAGTGTCACCCGCCTCTTCAGTGGACAGTAACATCCCATCATCTCAAGGCTACAAAAAGGAAGGCCGAGAGCAGG GCACTGGGAATAGCTACACTGATACAAGTGGACCTAAAGAAACGAGTTCCGCTACTCCGGGACGAGACTCCAAAACCATCCAAAAGGGAT CAGAAAGTGGGCGTGGGAGGCAGAAATCTCCTGCACAGAGTGACAGCACAACACAGAGAAGAACTGTAGGCAAAAAACAACCCAAAAAGG CTGAGAAGGCAGCTGCTGAAGAGCCTCGTGGAGGCCTGAAGATAGAAAGTGAAACCCCTGTAGACTTGGCTAGCAGCATGCCCTCCAGCA GACACAAAGCAGCCACCAAAGGCTCAAGGAAACCCAATATAAAGAAGGAGTCTAAGTCTTCCCCTCGACCTACAGCAGAGAAAAAGAAAT ATAAGTCAACAAGTAAATCTTCCCAGAAATCAAGGGAAATCATAGAAACAGATACCTCATCCTCAGATTCAGATGAAAGTGAGAGCCTTC CTCCTTCCTCACAAACTCCTAAGTACCCCGAGAGCAATAGGACTCCTGTTAAACCCTCCTCAGTGGAGGAAGAAGATAGCTTTTTTCGGC AACGAATGTTCTCTCCTATGGAAGAGAAGGAACTTCTTTCACCCCTCAGTGAGCCTGATGACAGGTACCCACTTATTGTGAAGATTGACC TGAATCTTTTGACTAGAATACCAGGAAAGCCTTACAAAGAAACAGAGCCGCCCAAGGGGGAAAAGAAAAATGTGCCAGAAAAGCACACGA GAGAGGCTCAGAAACAAGCCTCAGAAAAAGTTTCCAACAAAGGCAAGAGGAAGCATAAGAATGAAGATGATAACCGAGCCAGTGAGAGCA AGAAACCCAAAACGGAGGACAAGAATTCAGCAGGCCATAAGCCATCCAGCAACAGAGAGTCATCTAAGCAGAGTGCTGCAAAAGAAAAGG ATTTGTTGCCTTCTCCCGCTGGGCCTGTTCCTTCAAAAGATCCAAAAACAGAGCATGGCTCTCGGAAGAGGACTATTAGTCAGTCTTCTT CCTTAAAGTCAAGCAGTAACAGCAACAAGGAGACGAGTGGCAGCAGCAAAAACAGTTCCTCCACATCAAAGCAGAAGAAGACCGAAGGGA AGACTTCCAGTAGCTCCAAGGAGGTTAAGGTAAAGTGTTGGGGGCCTGGGGCTTTTGAAAATCATTCAACTTGCCATGTGACTTTTCCAG GGTGACACTGTGCTTTGAAATTATTGTAACATCTCAGTAAATATATAGGCCTATGTCTTTTACCCTCTATATGTAATAATCCTGATAAAT GAATACAGTGATATAAGACTGTGAAGGTGGTAAGTCAGCTGGTCACATACATATTGAAAGAAAAACCCTTGGGTACAGTGGCTCATACCT GTAGTCCCAGCTATTTGGGAGGCTAAGATGGAAGGATCATTTGAGGAATTTGAGTCCAGCCTGGGCAATGTGGTGAGACCCTGTCTGTAA AAGAACTTTAAAATTT >24394_24394_2_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000304058_AFF4_chr5_132234833_ENST00000378595_length(amino acids)=642AA_BP=138 MEISEMPGTATYRPQKVCLCPFLPAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLIL YPGAEAANLEEFILDSPVYPSTIIIIDGTWSQAKDIFYKNSLFRHPKQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSS GSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSAT PGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESK SSPRPTAEKKKYKSTSKSSQKSREIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEP DDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNR ESSKQSAAKEKDLLPSPAGPVPSKDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKVKCWGPGAF ENHSTCHVTFPG -------------------------------------------------------------- >24394_24394_3_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000510708_AFF4_chr5_132234833_ENST00000265343_length(transcript)=8615nt_BP=631nt GCTTCAATGCCACGGCCTGACCGGAGTGTCCGCCATGGAGTCGCAGAAAGAGGCACGAACACTCCAGGAGCCCGTTGCGCGGCCTTCTGG GGCCTCAAGCTCTCAGACGCCGAACGACAAGGAGCGGCGGGAGGGCGGCGCAGTGCCGGCGGCGGCTGCCCTGGGCGCAGAGGCGGACGA CGACAGTGCGGACGGGCTGTGGGAGCTGCCGGTGGAGCCGGCCGAGCGGAGGCCTGAGTGCACCCGCTGCAGCCGGCCTCAGAAAGTGTG TTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAGAGGAAAACAAAGTGTTGCG TACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTGAAGAAAGAGATCCTGAACT TTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAATTTATATTAGATTCTCCTGT TTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCTTGTTCCGACATCCCAAACA GGATTGTGATAAGACAATGCCGAGGAGTACACCAGGAAGTAACTCTGAACCTTCACACCATAATAGTGAAGGAGCAGATAACTCCAGGGA TGATTCTAGTAGCCACAGTGGATCTGAAAGCAGCTCTGGATCTGACTCAGAGAGTGAAAGTAGTTCCAGTGACAGTGAGGCAAATGAGCC ATCCCAGAGTGCATCTCCCGAGCCTGAACCCCCGCCAACAAACAAATGGCAACTTGATAATTGGCTGAATAAAGTGAACCCACATAAAGT GTCACCCGCCTCTTCAGTGGACAGTAACATCCCATCATCTCAAGGCTACAAAAAGGAAGGCCGAGAGCAGGGCACTGGGAATAGCTACAC TGATACAAGTGGACCTAAAGAAACGAGTTCCGCTACTCCGGGACGAGACTCCAAAACCATCCAAAAGGGATCAGAAAGTGGGCGTGGGAG GCAGAAATCTCCTGCACAGAGTGACAGCACAACACAGAGAAGAACTGTAGGCAAAAAACAACCCAAAAAGGCTGAGAAGGCAGCTGCTGA AGAGCCTCGTGGAGGCCTGAAGATAGAAAGTGAAACCCCTGTAGACTTGGCTAGCAGCATGCCCTCCAGCAGACACAAAGCAGCCACCAA AGGCTCAAGGAAACCCAATATAAAGAAGGAGTCTAAGTCTTCCCCTCGACCTACAGCAGAGAAAAAGAAATATAAGTCAACAAGTAAATC TTCCCAGAAATCAAGGGAAATCATAGAAACAGATACCTCATCCTCAGATTCAGATGAAAGTGAGAGCCTTCCTCCTTCCTCACAAACTCC TAAGTACCCCGAGAGCAATAGGACTCCTGTTAAACCCTCCTCAGTGGAGGAAGAAGATAGCTTTTTTCGGCAACGAATGTTCTCTCCTAT GGAAGAGAAGGAACTTCTTTCACCCCTCAGTGAGCCTGATGACAGGTACCCACTTATTGTGAAGATTGACCTGAATCTTTTGACTAGAAT ACCAGGAAAGCCTTACAAAGAAACAGAGCCGCCCAAGGGGGAAAAGAAAAATGTGCCAGAAAAGCACACGAGAGAGGCTCAGAAACAAGC CTCAGAAAAAGTTTCCAACAAAGGCAAGAGGAAGCATAAGAATGAAGATGATAACCGAGCCAGTGAGAGCAAGAAACCCAAAACGGAGGA CAAGAATTCAGCAGGCCATAAGCCATCCAGCAACAGAGAGTCATCTAAGCAGAGTGCTGCAAAAGAAAAGGATTTGTTGCCTTCTCCCGC TGGGCCTGTTCCTTCAAAAGATCCAAAAACAGAGCATGGCTCTCGGAAGAGGACTATTAGTCAGTCTTCTTCCTTAAAGTCAAGCAGTAA CAGCAACAAGGAGACGAGTGGCAGCAGCAAAAACAGTTCCTCCACATCAAAGCAGAAGAAGACCGAAGGGAAGACTTCCAGTAGCTCCAA GGAGGTTAAGGAAAAGGCTCCAAGTAGCTCCTCTAACTGTCCTCCATCTGCACCAACTCTTGATTCTTCTAAGCCTCGGAGAACAAAGCT TGTCTTTGATGACAGAAATTATTCAGCAGACCATTATTTACAAGAAGCAAAAAAGCTAAAGCACAATGCAGATGCATTGTCTGATAGGTT TGAGAAAGCTGTATACTATCTTGATGCTGTGGTATCTTTCATTGAATGTGGGAATGCATTAGAGAAGAATGCTCAGGAATCCAAATCCCC ATTCCCTATGTATTCAGAGACGGTGGATCTCATCAAATACACTATGAAGCTAAAGAATTACTTGGCACCAGATGCTACAGCTGCAGATAA ACGACTCACAGTACTTTGCCTGCGATGCGAGTCTTTGCTGTACCTGAGGCTGTTCAAACTGAAGAAGGAAAATGCTCTGAAGTACTCAAA GACACTGACAGAGCACCTGAAGAATTCTTATAATAATTCTCAAGCACCATCGCCTGGCTTGGGAAGCAAAGCTGTGGGGATGCCTTCCCC TGTTTCTCCAAAGCTGTCACCAGGCAATTCAGGAAATTATTCATCTGGGGCCAGTAGTGCTTCTGCAAGTGGTTCTTCAGTGACCATTCC ACAGAAGATCCACCAGATGGCAGCCAGCTATGTTCAGGTCACATCCAACTTCCTCTATGCCACCGAAATTTGGGACCAAGCTGAACAGCT TTCCAAAGAGCAAAAAGAATTCTTTGCTGAACTGGATAAAGTAATGGGCCCTCTCATCTTTAATGCAAGCATCATGACAGATCTAGTTCG TTATACCCGGCAGGGACTGCACTGGCTTCGCCAGGATGCCAAGTTGATATCTTGAACTGAACACATTCTCGTTGCCTCTGATTTTCTCCA CAACACTGTGTCACATCACGAAGGAAAACTGCCATAACATACCACCTAGTCGACACTAAGAATGAGGAATAGTTTTCTCCTCGTTGGTTC ATGTGTTGTTGTTTTTGATAATCCAAAGCGATCATGTCAGTTGGCCCTTTAATATTTCCAATGTGAAAGATTATTTAAATGCTTTTAAAT CTGCAGCACATTGATAAGATGGTTTCCGTGAGCTATGATAAGATTGAAATTCCAGTTGCAATTCATAACTAATGAATTGAAATTTTATTT ATTTTAATTTTTTTAAGTTCCCAGATTGGGGCTAGTTTAAGACTTAGTTATTTCTGCCTATAAATTTACTCTGTTGAATATTTAGCATAA ATTTAATGTAGACATTTTTATTTATATACCTTGGGAGCTTTATTACCTAATATCTTTTTGTGGTAGCTGTTCTAAGAGTAAGAATTGGTT CGTCTAAAATAAGGACATATTCTTTCTACACCTGCTACCTGACCTGATATTTGAAATCTTAACTCCAATTTTATTATTGTGGAATTTACA GTTAGTATTAAGGATATTCTTCTACACATGAAAAAATCACTTAAATATGAGAAAATGGCATTCTACATGTATGTACTATGAAATGTGTCT GATTTGGTATGCATTATTTCAAAAACTGTGAATGTGTGTTAATAACACTACAGCAATCACACAGTGACTATAGCTTGCATTTAATGCATT ACAAAAGAGGGAGGACAAACTTTCTAGAAGAAGCATTTCATGTTGAAGGGTTTCATAAAAGGACAATCCTGAACGTTACGGATTTTATTA AAACCATATGTTATTTTTTGTTGCTAATCATTTGACACTTAATCGAAACAGAATAAGTTACTGTGGAAAAAAGGATGATCCAACTCCTGA GGATTGCCGCCTGTGTGTCTTTAATTGATTATCTTTGATAGTTAGAGTTATTTTTCAGATTTTTCCCCCTCATACTGGATTGTGATGCTC TGATATGAGCATGCAATGACTGATACAGAAATAGGCTGGAGCTTCGGTGTGTGCTTTTGCTATACAGCTTACAGTTCTAATGCCTGATGT AGAGATGATGAATTTCTCCTTTTTAAACCTATCTTCTGTTTACTCCTTTTGCATTATGAAGGCCCTCTTCAATGATGTATGTTTCTGATG GAATCAGAAAATTTCACACTAGAAAAGTGTACCTAACTTGATTCAGTGTGAGCTCTTGGGACAGGGAGTGGAGCCAGGGGTAGAGCTTAA AGAAGCTGGCTCTGTAAGAGTTGTATATCAAAGTACCTTTTGCTACAAGGTGCATATAGAAGTCTAAGATAAGAAATGTACCCTCTATAC TTTATTTTTCATGCCCCTATCATGTTTGGTGTGCCTTAAATCTTACCTTTAAATGAAGACTCTATGGATTGTTTACAAATGAAGTTTTAC ACTAGGACCAGATCGTCCATACATGATTGGTCTTCTACAATAATAATGTTCAATTCTTTCATTTTAAATCTTTCTTTAGGGTCATATAAA GATTAGTTCTTTCAGAAAAGCTATTGCTTTGGTACATGACTTAGTCTAACCAGTTGGGTAATGCTGCTTTGAAAAATAGTTTGTCCCTCT CCCCATTCCAAAAATGAATCCATTCAGTCAGAAAAAAAGATTATCCTACTATTTGTAGATGATTGCTAAGGCTTGAAATAGGAAAGGGGA AAGAAGGGATAGAAAAGTTTCAAGTCCAGTAGTGCAGTGAATCCTTTGTGTTTGAGACTTTTTTACACTTATTTCTGAAGTTAGTGAACT TTCATTGTCCCTGTGGCCTCATATTTATAGAGCTTCTTAACTGTTTTGTACCTCAGATTGTTTTTAGATGTCATTGAAGATTGAGATGTA CAAATTATGTTGAATTTAACCTGTTTCTCTTGGAGAAATTGCCTCTGATATCTTTCTAACTTAATCTTAGTGTGTTCTAGGAACAGTTTT CCATAAGAGGACAACTTCTCAATGATCATGATAGTTATTTAGTAAGAAATAATGGTTGTTAATCAAATACATGTTATGTCTTGTCCTTCT CTGATTTTTCTGACTTGGATTCCTTAATTTGCAGTGATGTCTTAGAAATGGAAAAAGTATCCTCTGGGCTTTCAGACTTTCAGCAACAAC AGCCAGTGGGATACCTCTGAGTTCTTGTGTTCTAGTCTCTTGTATGTCCTGAAAGGCAGCAGGAGCATTTTTGGGGTCACACTGATATTT TGTTAAAGCAGAGTTTCCTGCATGGTTTATGGTGCTGCTCTAATATTTTCTCTTTAAAACTGTGTCAATTTTTGGAGAATGAATTTTTCA ACCTTTTCATTGTGGAGGATTTTTCCCACAAGGTAGTAATGGGCAATGGATCAAAATCCTATCATAAATGATTGAATTTTCAATGTCATA GTGTGTGGAAATACTACTCCCTTTCCTCCATGTCTATCTTCTTAGATGTTCTGTCTTTGTCATCATCTGCTCCAGCACATACTTTGGACT CCTTTACAGGTGACCTTCCCCCCTCCCTCCTCAATAGGTGTCCTCAGTGTTTTCTAAGCATTTAAAACTGAATTTGACAAGTGGCTAAAA ACTTAGTCTGAGACTTGTACTTAGTATATGGTTAATTATAGAAACAACAACTATTTTAAACAGTTACTCTGTTGACTGCTCTTTATGACT ACACTTGTATGCCAGGAGGCAGCAGCCTATACACCATTAGACTCTTTACAAGCAACCAACGAACCAATTGCAGTGGTTGCAGTTGTCACA GTAGTCTTGCCTGGGCCAGACTGGGCTGGGCTGTGGGAAGCATTCCCCTTCAGGGGAGTTTCCACAGCTCAGCCCAGGCTCCAGTCTGGC TAGAGAGCATCCAGCCCATTCCTTGCCTCAGTGCCACCTTTTTCTGGGCAAGTAGCCAAGAAGTGACTTTATATGCAGTGAGTACTTCAG ATAAACTTACAGCTACAGCTGCCGAAGAGTGGAGAAGGTTGACCACCATTTATTTAATTCTCTAGTGTAAAAACAATTGAGAGCAGTGTG CGTGAGCCCACAGACACCTGTGTTTCTGGGAGCTCTGGCAGTGGCGGATTCATAGGCACTTGGGCTGCACTTTGAATGACACACTTGGCT TTATTAGATTCACTAGTTTTTAAAAAATTGTTGTTCGTTTCTTTTCATTAAAGGTTTAATCAGACAGATCAGACAGCATAATTTTGTATT TAATGACAGAAACGTTGGTACATTTCTTCATGAATGAGCTTGCATTCTGAAGCAAGAGCCTACAAAAGGCACTTGTTATAAATGAAAGTT CTGGCTCTAGAGGCCAGTACTCTGGAGTTTCAGAGCAGCCAGTGATTGTTCCAGTCAGTGATGCCTAGTTATATAGAGGAGGAGTACACT GTGCACTCTTCTAGGTGTAAGGGTATGCAACTTTGGATCTTAAAATTCTGTACACATACACACTTTATATATATGTATGTATGTATGAAA ACATGAAATTAGTTTGTCAAATATGTGTGTGTTTAGTATTTTAGCTTAGTGCAACTATTTCCACATTATTTATTAAATTGATCTAAGACA CTTTCTTGTTGACACCTTGAATATTAATGTTCAAGGGTGCAATGTGTATTCCTTTAGATTGTTAAAGCTTAATTACTATGATTTGTAGTA AATTAACTTTTAAAATGTATTTGAGCCCTTCTGTAGTGTCGTAGGGCTCTTACAGGGTGGGAAAGATTTTAATTTTCCAGTTGCTAATTG AACAGTATGGCCTCATTATATATTTTGATTTATAGGAGTTTGTGTCTGGGTCCCAGGAACATCTACTGGGGATGACTGTTAGGCAGCTTG TGATGATGTTTTTTAAAAAACCTAAGTAACTTGGGGAGACAGAGCATTTCAAACCCATATAGACACCTATCATACCTGTATATCCCCTAA TACATGGAACATAAATTTCATTTCAGCTTTATGCATTAATGTATTGAAGAGGCAGGCTTTTTTTCCAGTAATAATACTGTACATCTAAGG TTGCTATTCAGTAAAACTAATAGAAGAGATAATTATTGAATACCTTGGAATATGTAGTGAGAAGAGGCCAAATTTTTCATGTTTGTGAGC ATGTCTTTCAGATACTCGCTAATGGAGAAATTCACTTTAGACCTCTAGACCCCAAAACCAAGTTAGCAAGTGACAAAAAGTAAATTATTA ATAGTCTGTAAAGTGGATGCTGGTCTTACAAAGCTCCTATTCACATGAACCCTATGGTTAATTAGAAAGAACTTGCTGTCTCCAGAAAAG GGAATGGAAATAATAACTATGTATCTTCTTTTCATGTAATTTGGTCACAGAATAAGGTATTCAAGTTAAGTCTAATCCAAGTCTTAGAGA TCTTTAAGTATCCTAAAATAGCAGCCTAAGTAGTCATCATGTAAAGAAGTTGACTTTCAGGAATGTCAGCATTGACCTCTCCTTGCCACT GTTACTCAGCTAAACATAACTTGCCATTCTTAAAAATAAAAAAGCTCCCACCCAGAAACTCTAGTGATACTCAGTTTTGACCTCTTACTG CTTCCATGTGGGACTTCTTTTCAGCTTTTAACCATTGGAATTTTCTACCTGCTATGTTCCTCTCTGGAAAATATCAATTTGGAAATGCTG CCTTTCAAATCAATGCCATGATCATCCATATTGTTGAGTTTGTTGTTGGTGTTCCAGAAGTGTCCCCATTTTACAACTTTATGCACACAC CTGGCAAATCATTAACATGAGCATTCAACAGTACTGGGATGGGTGGGGTGGGGGTAGGGGGCTCACCAACAGAACTGGCCAGTTGACATT GCCTGAAAAGGCACCACCTTTAAGGGCCAGTTGTGGGGTTGGTAAGCACAGTTATGAAAATTTCTATCTAGCCTCCGTTTTGAATGGTTT TAAGAAATTTTGTATATGGAGGATGGAAATGCTTATATATTTATTGAAAATCCTTTTATTTGAAATTAAAATTATTTGGTATATAATTGT TTGATATTTGGGGAGGGTTTTGGAGGGGAGATAATGTCACTGATAAATTAAAAGCCTGTTGATTTTGCAGAAAGGTACTGTTAGTGACTG ATAAGGATGCCTTTGTTTTGTACATGAACCAAATCTTTGTTTTACATTTCTTTTATCCAAAATATTTAGGCATCTGACATTTTCAACCAG AATTTCAATTATATACTGTGATTTTTATTTGTTGCAATACATTACAATTTCAGAGGTACTTTGGGGCTCAAAAGCTAGGATTTCTAAGTC AGTATGTGCATTTCACACGATAAAGCTGTTAATGGTGAGCAAAGTATTATATACTAACTAGATTTTTCCACATCTGTATAGTATATTATA TGTATTTTGTGGTATTGAGAGTATAGAAAGTTTAGAGTGTCAAACATGCGTTTAATGTGTATTTTTAAACAAATTTATGGCAATTAAAAT ATTTGGAGACAAGGGTATCACATTTCAATTTGTAAAGATCTTTTTAACTCTACTGTGTCATTAAGATGCTTTGTACAATGCCAAACCATA GTTGGAGAAACTAAGTTTAATAAATATCAAATAGATTTTCTGTATTAAAGTTACTGAACACTGTA >24394_24394_3_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000510708_AFF4_chr5_132234833_ENST00000265343_length(amino acids)=972AA_BP=205 MTGVSAMESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFL PAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTI IIIDGTWSQAKDIFYKNSLFRHPKQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSAS PEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPA QSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSR EIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPY KETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPS KDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKEKAPSSSSNCPPSAPTLDSSKPRRTKLVFDDR NYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSETVDLIKYTMKLKNYLAPDATAADKRLTVL CLRCESLLYLRLFKLKKENALKYSKTLTEHLKNSYNNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGNYSSGASSASASGSSVTIPQKIHQ MAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLVRYTRQGLHWLRQDAKLIS -------------------------------------------------------------- >24394_24394_4_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000510708_AFF4_chr5_132234833_ENST00000378595_length(transcript)=2427nt_BP=631nt GCTTCAATGCCACGGCCTGACCGGAGTGTCCGCCATGGAGTCGCAGAAAGAGGCACGAACACTCCAGGAGCCCGTTGCGCGGCCTTCTGG GGCCTCAAGCTCTCAGACGCCGAACGACAAGGAGCGGCGGGAGGGCGGCGCAGTGCCGGCGGCGGCTGCCCTGGGCGCAGAGGCGGACGA CGACAGTGCGGACGGGCTGTGGGAGCTGCCGGTGGAGCCGGCCGAGCGGAGGCCTGAGTGCACCCGCTGCAGCCGGCCTCAGAAAGTGTG TTTGTGTCCATTTCTCCCAGCGCACCCTCTGCATATCTCTACCCACTTGTACATAATTCAGCATCCAGCAGAGGAAAACAAAGTGTTGCG TACAGTTCCTCTACTAGCAGCATGCCTCCCCCAGGACAAGTGTAAAGTGAAGATCGGTCGTCGCTTCAGTGAAGAAAGAGATCCTGAACT TTCAACTGTTTGCCGGAAGTCTGGTACATTAATATTATATCCAGGGGCTGAAGCTGCTAATTTGGAAGAATTTATATTAGATTCTCCTGT TTATCCTTCTACAATCATCATCATTGATGGTACATGGAGCCAGGCTAAGGACATTTTCTATAAGAACTCCTTGTTCCGACATCCCAAACA GGATTGTGATAAGACAATGCCGAGGAGTACACCAGGAAGTAACTCTGAACCTTCACACCATAATAGTGAAGGAGCAGATAACTCCAGGGA TGATTCTAGTAGCCACAGTGGATCTGAAAGCAGCTCTGGATCTGACTCAGAGAGTGAAAGTAGTTCCAGTGACAGTGAGGCAAATGAGCC ATCCCAGAGTGCATCTCCCGAGCCTGAACCCCCGCCAACAAACAAATGGCAACTTGATAATTGGCTGAATAAAGTGAACCCACATAAAGT GTCACCCGCCTCTTCAGTGGACAGTAACATCCCATCATCTCAAGGCTACAAAAAGGAAGGCCGAGAGCAGGGCACTGGGAATAGCTACAC TGATACAAGTGGACCTAAAGAAACGAGTTCCGCTACTCCGGGACGAGACTCCAAAACCATCCAAAAGGGATCAGAAAGTGGGCGTGGGAG GCAGAAATCTCCTGCACAGAGTGACAGCACAACACAGAGAAGAACTGTAGGCAAAAAACAACCCAAAAAGGCTGAGAAGGCAGCTGCTGA AGAGCCTCGTGGAGGCCTGAAGATAGAAAGTGAAACCCCTGTAGACTTGGCTAGCAGCATGCCCTCCAGCAGACACAAAGCAGCCACCAA AGGCTCAAGGAAACCCAATATAAAGAAGGAGTCTAAGTCTTCCCCTCGACCTACAGCAGAGAAAAAGAAATATAAGTCAACAAGTAAATC TTCCCAGAAATCAAGGGAAATCATAGAAACAGATACCTCATCCTCAGATTCAGATGAAAGTGAGAGCCTTCCTCCTTCCTCACAAACTCC TAAGTACCCCGAGAGCAATAGGACTCCTGTTAAACCCTCCTCAGTGGAGGAAGAAGATAGCTTTTTTCGGCAACGAATGTTCTCTCCTAT GGAAGAGAAGGAACTTCTTTCACCCCTCAGTGAGCCTGATGACAGGTACCCACTTATTGTGAAGATTGACCTGAATCTTTTGACTAGAAT ACCAGGAAAGCCTTACAAAGAAACAGAGCCGCCCAAGGGGGAAAAGAAAAATGTGCCAGAAAAGCACACGAGAGAGGCTCAGAAACAAGC CTCAGAAAAAGTTTCCAACAAAGGCAAGAGGAAGCATAAGAATGAAGATGATAACCGAGCCAGTGAGAGCAAGAAACCCAAAACGGAGGA CAAGAATTCAGCAGGCCATAAGCCATCCAGCAACAGAGAGTCATCTAAGCAGAGTGCTGCAAAAGAAAAGGATTTGTTGCCTTCTCCCGC TGGGCCTGTTCCTTCAAAAGATCCAAAAACAGAGCATGGCTCTCGGAAGAGGACTATTAGTCAGTCTTCTTCCTTAAAGTCAAGCAGTAA CAGCAACAAGGAGACGAGTGGCAGCAGCAAAAACAGTTCCTCCACATCAAAGCAGAAGAAGACCGAAGGGAAGACTTCCAGTAGCTCCAA GGAGGTTAAGGTAAAGTGTTGGGGGCCTGGGGCTTTTGAAAATCATTCAACTTGCCATGTGACTTTTCCAGGGTGACACTGTGCTTTGAA ATTATTGTAACATCTCAGTAAATATATAGGCCTATGTCTTTTACCCTCTATATGTAATAATCCTGATAAATGAATACAGTGATATAAGAC TGTGAAGGTGGTAAGTCAGCTGGTCACATACATATTGAAAGAAAAACCCTTGGGTACAGTGGCTCATACCTGTAGTCCCAGCTATTTGGG AGGCTAAGATGGAAGGATCATTTGAGGAATTTGAGTCCAGCCTGGGCAATGTGGTGAGACCCTGTCTGTAAAAGAACTTTAAAATTT >24394_24394_4_DTWD2-AFF4_DTWD2_chr5_118264232_ENST00000510708_AFF4_chr5_132234833_ENST00000378595_length(amino acids)=709AA_BP=205 MTGVSAMESQKEARTLQEPVARPSGASSSQTPNDKERREGGAVPAAAALGAEADDDSADGLWELPVEPAERRPECTRCSRPQKVCLCPFL PAHPLHISTHLYIIQHPAEENKVLRTVPLLAACLPQDKCKVKIGRRFSEERDPELSTVCRKSGTLILYPGAEAANLEEFILDSPVYPSTI IIIDGTWSQAKDIFYKNSLFRHPKQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSAS PEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNSYTDTSGPKETSSATPGRDSKTIQKGSESGRGRQKSPA QSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKSR EIIETDTSSSDSDESESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPY KETEPPKGEKKNVPEKHTREAQKQASEKVSNKGKRKHKNEDDNRASESKKPKTEDKNSAGHKPSSNRESSKQSAAKEKDLLPSPAGPVPS KDPKTEHGSRKRTISQSSSLKSSSNSNKETSGSSKNSSSTSKQKKTEGKTSSSSKEVKVKCWGPGAFENHSTCHVTFPG -------------------------------------------------------------- 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Fusion Gene PPI Analysis for DTWD2-AFF4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for DTWD2-AFF4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for DTWD2-AFF4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C0000772 | Multiple congenital anomalies | 1 | CTD_human | |
| Tgene | C0005941 | Bone Diseases, Developmental | 1 | CTD_human | |
| Tgene | C0009241 | Cognition Disorders | 1 | CTD_human | |
| Tgene | C0018273 | Growth Disorders | 1 | CTD_human | |
| Tgene | C0018798 | Congenital Heart Defects | 1 | CTD_human | |
| Tgene | C0024115 | Lung diseases | 1 | CTD_human | |
| Tgene | C0028754 | Obesity | 1 | CTD_human | |
| Tgene | C0282631 | Facies | 1 | CTD_human | |
| Tgene | C4085597 | CHOPS SYNDROME | 1 | CTD_human;ORPHANET;UNIPROT |
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