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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANK2-ARHGAP31 (FusionGDB2 ID:HG287TG57514)

Fusion Gene Summary for ANK2-ARHGAP31

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK2-ARHGAP31
Fusion gene ID: hg287tg57514
HgeneTgene
Gene symbol

ANK2

ARHGAP31

Gene ID

287

57514

Gene nameankyrin 2Rho GTPase activating protein 31
SynonymsANK-2|CFAP87|FAP87|LQT4|brank-2AOS1|CDGAP
Cytomap('ANK2')('ARHGAP31')

4q25-q26

3q13.32-q13.33

Type of geneprotein-codingprotein-coding
Descriptionankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrinrho GTPase-activating protein 31Cdc42 GTPase-activating protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357077, ENST00000506722, 
ENST00000264366, ENST00000394537, 
ENST00000504887, ENST00000509550, 
ENST00000510275, 
Fusion gene scores* DoF score11 X 12 X 4=5283 X 3 X 3=27
# samples 153
** MAII scorelog2(15/528*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ANK2 [Title/Abstract] AND ARHGAP31 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANK2(114304891)-ARHGAP31(119013220), # samples:1
Anticipated loss of major functional domain due to fusion event.ANK2-ARHGAP31 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ARHGAP31 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ARHGAP31 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ARHGAP31 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ARHGAP31 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARHGAP31 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-A75P-01AANK2chr4

114304891

-ARHGAP31chr3

119013220

+


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Fusion Gene ORF analysis for ANK2-ARHGAP31

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000357077ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
In-frameENST00000506722ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
intron-3CDSENST00000264366ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
intron-3CDSENST00000394537ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
intron-3CDSENST00000504887ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
intron-3CDSENST00000509550ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+
intron-3CDSENST00000510275ENST00000264245ANK2chr4

114304891

-ARHGAP31chr3

119013220

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000506722ANK2chr4114304891-ENST00000264245ARHGAP31chr3119013220+17368805110857861892

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000506722ENST00000264245ANK2chr4114304891-ARHGAP31chr3119013220+0.0008063110.9991937

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Fusion Genomic Features for ANK2-ARHGAP31


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ANK2-ARHGAP31


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:114304891/chr3:119013220)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461158_130447143958.0DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461450_153547143958.0DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46463569_365347143958.0DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646968_115647143958.0DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471158_130426181864.0DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471450_153526181864.0DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47473569_365326181864.0DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747968_115626181864.0DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461289_142347143958.0RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461806_198347143958.0RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471289_142326181864.0RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471806_198326181864.0RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646129_15847143958.0RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646162_19147143958.0RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461806_181747143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461818_182947143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461830_184147143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461842_185347143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461854_186547143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461866_187747143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461878_188947143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461890_190047143958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461901_191247143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461913_192447143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461925_193547143958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461936_194747143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646193_22047143958.0RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461948_195947143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461960_197147143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-46461972_198347143958.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646232_26147143958.0RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646265_29447143958.0RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646298_32747143958.0RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-464630_6247143958.0RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646331_36047143958.0RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646364_39347143958.0RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646397_42647143958.0RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646430_45947143958.0RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646463_49247143958.0RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646496_52547143958.0RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646529_55847143958.0RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646562_59147143958.0RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646595_62447143958.0RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646628_65747143958.0RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-464663_9247143958.0RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646661_69047143958.0RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646694_72347143958.0RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646727_75647143958.0RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646760_78947143958.0RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646793_82247143958.0RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-464696_12547143958.0RepeatNote=ANK 3
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747129_15826181864.0RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747162_19126181864.0RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471806_181726181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471818_182926181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471830_184126181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471842_185326181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471854_186526181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471866_187726181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471878_188926181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471890_190026181864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471901_191226181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471913_192426181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471925_193526181864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471936_194726181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747193_22026181864.0RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471948_195926181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471960_197126181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-47471972_198326181864.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747232_26126181864.0RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747265_29426181864.0RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747298_32726181864.0RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-474730_6226181864.0RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747331_36026181864.0RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747364_39326181864.0RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747397_42626181864.0RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747430_45926181864.0RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747463_49226181864.0RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747496_52526181864.0RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747529_55826181864.0RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747562_59126181864.0RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747595_62426181864.0RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747628_65726181864.0RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-474763_9226181864.0RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747661_69026181864.0RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747694_72326181864.0RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747727_75626181864.0RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747760_78926181864.0RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747793_82226181864.0RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-474796_12526181864.0RepeatNote=ANK 3
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245-112673_790331445.0Compositional biasNote=Pro-rich
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245-112971_974331445.0Compositional biasNote=Poly-Ser

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451158_130401873.0DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451450_153501873.0DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1453569_365301873.0DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145968_115601873.0DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141158_13040556.0DomainZU5 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141450_15350556.0DomainDeath 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1143569_36530556.0DomainDeath 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114968_11560556.0DomainZU5 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451289_142301873.0RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451806_198301873.0RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141289_14230556.0RegionNote=UPA domain
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141806_19830556.0RegionNote=Repeat-rich region
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145129_15801873.0RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145162_19101873.0RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451806_181701873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451818_182901873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451830_184101873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451842_185301873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451854_186501873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451866_187701873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451878_188901873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451890_190001873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451901_191201873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451913_192401873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451925_193501873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451936_194701873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145193_22001873.0RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451948_195901873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451960_197101873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-1451972_198301873.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145232_26101873.0RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145265_29401873.0RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145298_32701873.0RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-14530_6201873.0RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145331_36001873.0RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145364_39301873.0RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145397_42601873.0RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145430_45901873.0RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145463_49201873.0RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145496_52501873.0RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145529_55801873.0RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145562_59101873.0RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145595_62401873.0RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145628_65701873.0RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-14563_9201873.0RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145661_69001873.0RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145694_72301873.0RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145727_75601873.0RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145760_78901873.0RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145793_82201873.0RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-14596_12501873.0RepeatNote=ANK 3
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114129_1580556.0RepeatNote=ANK 4
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114162_1910556.0RepeatNote=ANK 5
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141806_18170556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141818_18290556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141830_18410556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141842_18530556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141854_18650556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141866_18770556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141878_18890556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141890_19000556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141901_19120556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141913_19240556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141925_19350556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141936_19470556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114193_2200556.0RepeatNote=ANK 6
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141948_19590556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141960_19710556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-1141972_19830556.0RepeatNote=Repeat A
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114232_2610556.0RepeatNote=ANK 7
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114265_2940556.0RepeatNote=ANK 8
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114298_3270556.0RepeatNote=ANK 9
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-11430_620556.0RepeatNote=ANK 1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114331_3600556.0RepeatNote=ANK 10
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114364_3930556.0RepeatNote=ANK 11
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114397_4260556.0RepeatNote=ANK 12
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114430_4590556.0RepeatNote=ANK 13
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114463_4920556.0RepeatNote=ANK 14
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114496_5250556.0RepeatNote=ANK 15
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114529_5580556.0RepeatNote=ANK 16
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114562_5910556.0RepeatNote=ANK 17
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114595_6240556.0RepeatNote=ANK 18
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114628_6570556.0RepeatNote=ANK 19
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-11463_920556.0RepeatNote=ANK 2
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114661_6900556.0RepeatNote=ANK 20
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114694_7230556.0RepeatNote=ANK 21
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114727_7560556.0RepeatNote=ANK 22
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114760_7890556.0RepeatNote=ANK 23
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114793_8220556.0RepeatNote=ANK 24
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-11496_1250556.0RepeatNote=ANK 3
TgeneARHGAP31chr4:114304891chr3:119013220ENST00000264245-11221_216331445.0DomainRho-GAP


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Fusion Gene Sequence for ANK2-ARHGAP31


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4354_4354_1_ANK2-ARHGAP31_ANK2_chr4_114304891_ENST00000506722_ARHGAP31_chr3_119013220_ENST00000264245_length(transcript)=17368nt_BP=8051nt
ACAGTCTGAGGCTGTAATGGGAAAGTCGGTTCCTGGGCTGCTGTCTCATAGACATCAGCTTGCAGGGAAGCTGGGGGCTCTCCGAATTGC
CCTGCTCCGGGGCCCCTCCTGCTGCGTGACTCACAGGCACATTGCAGAGAGAAGCTGCCGCTCCCAGTAAGTAATGAAAAGAGACATGAA
GAATTGGTATTTCAAATGACCACCATGTTGCAAAAGTCTGACAGCAATGCAAGCTTCCTCCGTGCTGCCAGAGCAGGCAACCTGGACAAA
GTTGTGGAATATCTGAAGGGGGGCATAGACATCAATACCTGCAATCAGAATGGACTCAACGCTCTCCATCTGGCTGCCAAGGAAGGCCAC
GTGGGGCTGGTGCAGGAGCTGCTGGGAAGAGGGTCCTCTGTGGATTCTGCCACTAAGAAGGGAAATACCGCTCTTCACATTGCATCTTTG
GCTGGACAAGCAGAAGTTGTCAAAGTTCTTGTTAAGGAAGGAGCCAATATTAATGCACAGTCTCAGAATGGCTTTACTCCTTTATACATG
GCTGCCCAAGAGAATCACATTGATGTTGTAAAATATTTGCTGGAAAATGGAGCTAATCAGAGCACTGCTACAGAGGATGGCTTTACTCCT
CTAGCTGTGGCACTCCAGCAAGGACACAACCAGGCGGTGGCCATCCTCTTGGAGAATGACACCAAAGGGAAAGTGAGGCTGCCAGCTCTG
CATATTGCCGCTAGGAAAGACGACACCAAATCTGCCGCACTTCTGCTTCAGAATGACCACAATGCTGACGTACAATCCAAGATGATGGTG
AATAGGACAACTGAGAGTGGTTTTACCCCTTTGCACATAGCTGCACATTACGGAAATGTCAACGTGGCAACTCTTCTTCTAAACCGGGGA
GCTGCTGTGGACTTCACAGCCAGGAATGGAATCACTCCTCTGCATGTGGCTTCCAAAAGAGGAAATACAAACATGGTGAAGCTCTTACTG
GATCGAGGCGGTCAGATCGATGCCAAAACTAGGGATGGGTTGACACCACTTCACTGTGCTGCACGAAGTGGGCATGACCAAGTGGTGGAA
CTTCTGTTGGAACGGGGTGCCCCCTTGCTGGCAAGGACTAAGAATGGGCTGTCTCCACTACACATGGCTGCCCAGGGAGACCACGTGGAA
TGTGTGAAGCACCTGTTACAGCACAAGGCACCTGTTGATGATGTCACCCTAGACTACCTGACAGCCCTCCACGTTGCTGCGCACTGTGGC
CACTACCGTGTAACCAAACTCCTTTTAGACAAGAGAGCCAATCCGAACGCCAGAGCCCTGAATGGTTTTACTCCACTGCACATTGCCTGC
AAGAAAAACCGCATCAAAGTCATGGAACTGCTGGTGAAATATGGGGCTTCAATCCAAGCTATAACAGAGTCTGGCCTCACACCAATACAT
GTGGCTGCCTTCATGGGCCACTTGAACATTGTCCTCCTTCTGCTGCAGAACGGAGCCTCTCCAGATGTCACTAACATTCGTGGTGAGACG
GCACTACACATGGCAGCCCGAGCCGGGCAGGTGGAAGTGGTCCGATGCCTCCTGAGAAATGGTGCCCTTGTTGATGCCAGAGCCAGGGAG
GAACAGACACCTTTACATATTGCCTCCCGCCTGGGTAAGACAGAAATTGTCCAGCTGCTTCTACAACATATGGCTCATCCAGATGCGGCC
ACTACAAATGGGTACACACCACTGCACATCTCTGCCCGGGAGGGCCAGGTGGATGTGGCATCAGTCCTATTGGAAGCAGGAGCAGCCCAC
TCCTTAGCTACCAAGAAGGGTTTTACTCCCCTGCATGTAGCAGCCAAGTATGGAAGCCTGGATGTGGCAAAACTTCTCTTGCAACGCCGT
GCTGCCGCAGATTCTGCAGGGAAGAACGGCCTTACCCCGCTCCATGTTGCTGCTCATTATGACAACCAGAAGGTGGCGCTGCTGTTACTG
GAGAAGGGTGCTTCCCCTCATGCCACTGCCAAGAATGGCTATACTCCGTTACATATTGCTGCCAAGAAGAATCAAATGCAGATAGCTTCC
ACACTCCTGAACTATGGAGCAGAGACAAACATTGTGACAAAGCAAGGAGTAACTCCACTCCATCTGGCCTCGCAGGAGGGGCACACAGAT
ATGGTTACCTTGCTTCTGGATAAGGGAGCCAATATCCACATGTCAACTAAGAGTGGACTCACATCCTTACACCTTGCAGCCCAGGAAGAT
AAAGTGAATGTTGCTGATATTCTCACCAAGCATGGAGCTGATCAGGATGCTCATACAAAGCTTGGTTACACACCTTTAATTGTGGCCTGT
CACTATGGAAATGTGAAAATGGTCAACTTTCTTCTGAAGCAGGGAGCAAATGTTAACGCAAAAACCAAGAACGGCTACACGCCTTTGCAC
CAGGCCGCTCAGCAGGGTCACACGCACATCATCAACGTCCTGCTCCAGCATGGGGCCAAGCCCAACGCCACCACTGCGAATGGCAACACT
GCCTTGGCGATTGCTAAGCGTCTGGGCTACATCTCCGTGGTCGACACCCTGAAGGTTGTGACTGAGGAGGTCACCACCACCACCACAACT
ATTACAGAAAAACACAAACTAAATGTACCTGAGACGATGACTGAGGTTCTTGATGTTTCTGATGAAGAGGGTGATGACACAATGACTGGT
GATGGGGGAGAATACCTTAGGCCTGAGGACCTAAAAGAACTGGGTGATGACTCACTACCCAGCAGTCAGTTCCTGGATGGTATGAATTAC
CTGCGATACAGCTTGGAGGGAGGACGATCTGACAGCCTTCGATCCTTCAGTTCCGACAGGTCTCACACTCTGAGCCATGCCTCCTACCTG
AGGGACAGTGCCGTGATGGATGACTCAGTTGTGATTCCCAGTCACCAGGTGTCAACTCTAGCCAAGGAGGCAGAAAGGAATTCTTATCGC
CTAAGCTGGGGCACTGAGAACTTAGACAACGTGGCTCTTTCTTCTAGTCCTATTCATTCAGGCCGCGCCTCTCCATGTCTTGAACGTGAC
AACAGCAGTTTCCTGGTTAGTTTTATGGTGGATGCCCGAGGTGGTGCTATGCGAGGATGCAGACACAATGGGCTCCGAATCATTATTCCA
CCTCGGAAATGTACTGCTCCAACGCGAGTCACCTGCCGACTGGTCAAGCGCCACAGACTGGCAACAATGCCTCCAATGGTGGAAGGAGAA
GGCCTGGCCAGTCGCCTGATCGAAGTTGGACCTTCTGGTGCTCAGTTCCTTGGTAAACTTCACCTGCCAACGGCTCCTCCCCCACTTAAT
GAGGGAGAAAGTTTGGTCAGCCGCATTCTTCAGCTGGGGCCTCCTGGAACCAAATTCCTTGGGCCTGTGATCGTGGAGATCCCTCACTTT
GCGGCCCTTCGAGGAAAGGAAAGGGAACTGGTGGTCCTGCGCAGTGAGAATGGGGACAGCTGGAAAGAGCATTTCTGTGACTACACTGAA
GATGAATTGAATGAAATTCTTAACGGCATGGATGAAGTACTGGATAGCCCAGAAGACCTAGAAAAGAAACGAATCTGCCGCATCATCACC
CGAGACTTCCCACAGTACTTTGCAGTGGTGTCTCGTATCAAACAGGACAGCAATCTGATTGGCCCAGAAGGAGGTGTACTGAGCAGCACA
GTGGTGCCCCAGGTGCAGGCCGTCTTCCCAGAGGGGGCACTCACCAAGCGGATCCGCGTAGGCCTGCAGGCTCAACCTATGCACAGTGAG
CTGGTTAAGAAGATCCTAGGCAACAAAGCTACCTTCAGCCCTATAGTCACTTTGGAACCTAGAAGAAGAAAATTCCACAAACCAATTACC
ATGACCATTCCTGTCCCCAAAGCTTCAAGTGATGTCATGTTGAATGGTTTTGGGGGAGATGCACCAACCTTAAGATTACTATGCAGCATA
ACAGGTGGAACCACCCCTGCCCAGTGGGAAGATATTACAGGAACTACGCCATTAACATTTGTCAATGAATGTGTTTCCTTTACAACAAAC
GTGTCTGCCAGGTTCTGGCTGATAGATTGTCGACAGATCCAGGAATCCGTTACTTTTGCATCACAAGTATACAGAGAAATTATCTGCGTA
CCTTATATGGCCAAATTTGTAGTGTTTGCCAAATCACATGACCCCATTGAAGCCAGGTTGAGGTGTTTCTGCATGACTGATGATAAAGTG
GATAAGACCCTTGAACAACAAGAAAATTTTGCTGAGGTGGCCAGAAGCAGGGATGTGGAGGTGTTAGAAGGAAAACCCATCTACGTTGAT
TGTTTCGGCAACTTGGTACCATTAACTAAAAGTGGCCAGCATCATATATTCAGTTTTTTTGCCTTCAAAGAAAATAGACTTCCTCTATTT
GTCAAGGTACGCGATACGACTCAGGAACCTTGCGGACGACTATCATTTATGAAGGAGCCAAAATCCACGAGAGGCCTGGTGCATCAAGCT
ATTTGCAACTTAAACATCACTTTGCCGATTTATACAAAGGAATCAGAGTCAGATCAAGAACAGGAGGAAGAGATCGATATGACATCAGAA
AAAAATCCACAGGATGAGCAGGAACGGATCGAGGAAAGGCTGGCTTATATTGCTGATCACCTTGGCTTCAGCTGGACAGAATTAGCAAGA
GAACTGGATTTCACTGAGGAGCAAATTCATCAAATTCGAATTGAAAATCCCAACTCTCTTCAAGACCAGAGTCATGCACTGTTGAAGTAC
TGGCTAGAGAGGGATGGGAAACATGCTACAGATACCAACCTCGTTGAATGTCTCACCAAGATCAACCGAATGGATATTGTTCATCTCATG
GAGACCAACACAGAACCTCTCCAGGAGCGCATCAGTCATAGTTATGCAGAAATTGAACAGACCATTACACTGGATCATAGTGAAGGGTTC
TCGGTACTTCAAGAGGAGTTATGCACTGCACAGCACAAGCAGAAAGAGGAGCAAGCTGTTTCTAAAGAAAGTGAGACCTGCGATCACCCT
CCTATCGTCTCAGAGGAAGACATTTCTGTTGGTTATTCCACTTTTCAGGATGGCGTCCCCAAAACTGAGGGGGACAGCTCAGCAACAGCA
CTCTTTCCCCAAACTCACAAGGAGCAAGTTCAACAGGATTTCTCAGGGAAAATGCAAGACCTGCCTGAAGAGTCATCTCTGGAATATCAG
CAGGAATATTTTGTGACAACTCCAGGAACAGAAACATCAGAGACTCAGAAGGCTATGATAGTACCCAGCTCTCCCAGCAAGACACCTGAG
GAAGTTAGCACCCCTGCAGAGGAGGAGAAGCTGTACCTCCAGACCCCAACATCCAGCGAGCGGGGAGGCTCTCCCATCATACAAGAACCC
GAAGAGCCCTCAGAGCACAGAGAGGAGAGCTCTCCGCGGAAAACCAGCCTCGTAATAGTGGAGTCTGCCGATAACCAGCCTGAGACCTGT
GAAAGACTCGATGAAGATGCAGCTTTTGAAAAGGGAGACGATATGCCTGAAATACCCCCAGAAACAGTCACAGAAGAAGAATACATTGAT
GAGCATGGACACACCGTGGTAAAGAAGGTTACTAGGAAAATCATTAGGCGGTATGTATCCTCTGAAGGCACAGAGAAAGAAGAGATTATG
GTGCAGGGAATGCCACAGGAACCTGTCAACATCGAGGAAGGGGATGGCTATTCCAAAGTTATAAAGCGTGTTGTATTGAAGAGTGACACC
GAGCAGTCAGAGGACAACAATGAGTAAAGCCATCACACAGAAGAGGGCTGTGGTGAAGGACCAGCATGGAAAACGCATTGACTTGGAGCA
CCTGGAGGATGTACCAGAAGCACTAGACCAGGACGACCTCCAGCGCGATCTCCAGCAGCTCCTTCGGCATTTCTGCAAGGAGGACTTGAA
GCAAGAGGCCAAGTGAGGGGCTGCCCAGTTCTCACACCAGAAACCACACATTCACTCAATATGCAGCTTCCTGTTTCAGTAGGGGAGTGA
CCTAACTGGCCTAATTAATGGGATACCCCGACATTTCCACTGTTAGCAAATATACGGCATTTTGCTTTAGTTTTCCCCCATCCTCTTTAA
CTATAAAGCTAATTTGTGACCAAAGATGGCATCCTTCATACTGGATGCTGTATCCAATACTTTGTTGTGTCTGTGCTAACCTGGGAACTG
GCCACCTCCATTGTTCTTTGCTTCTGCACAAGATCCATGAAAATCCATTGATCAGAAGAACTTCACCTGCAGACCTCTTCAAGTGACACT
ATGTAGGAATCCTTCCAAGGAATATCTATGTACAATGTATATAGCTGAAATGCTCAGATGAACAACATATTAAAATTAAAACCACTGCCT
ATTGTAACTACACTGGGCATCAGAATAAAAGGCCTCTAGAAATTGCTGAACAATGGTTAATTAAGATATTGCTAACACAATCGAGTGATA
ATACAGTTTTACTGCAAAAGAAGCACTTCAAACCTATTATGTCCTTAGAACTTCCAGAGTAGCCACTGCTCCCAGTTAAAGGTGGGTCAG
TAGCCTTGCAGAACTGTCCTGAGAAGTTATTGCTGGTGCTGGCCAGCCATGGCTTAGGACTCCAACAGCCACTCTGAGGGAGGGGAGAAG
GGAGCAGAGGCCACGCAGAATGAACCGATGGGGTATTCAGTTGCTGGCAGCTACATTGTGTGGCATTCTAGCATCTTCAGGTCTTTAGAT
CTTGGACAAGTTGGCAGGGTATTTTAAAAGCTATAACTACTGTAGTTTTCCAGTTTTCATTGCTGCTTTAGCAAACCACGCTGTCTTACA
GTGGTACTTTCTTCTGGCCACTGCACTGTAGATAATTCATTGGAAACAAGATTTACCCACTACATAAAAGGTTAAACTCCTTCAGTATGT
TGGAGTGGTTTCTTTTTTTTTTTCTTTCTTTCTTTTTTTTCTTCAGGTTTATATCTTCTCTAATACCTGCATGTGGCGTTTAAAAATCAA
GACCACGGTCAAACCCCTCTTCTAATCACATTAATTGTTTCCATTCTTTTTACCCTGAGTGAGCACTTTTCACTTTCCAGCTAGGTCTGT
TTTTCAGCTTGCAGACAAGATTGAGAAATCCTTGAAAATTTGGTTTTGGTTAAAATTTTTGGTTTATTTATTTGAAATCCACACTCCCTT
GGAAACTCTTAAGTGCATTTGTGCACTTCTGTTTGTTTGTCTCAAAGAAGGGACTGTAACAATCTGAGTAATTTCCATGTCCTCTTCCTT
ATTCCTCTAGTGGTTGAAGCTGTGTAGCATTTTAACATATATATATTCACAAATATATTCATATAAACAGTATACATTTTGAATCAGTCA
TTTGTTAAAGAAAAGTATATTCAATGAAGATGAAATTTAAATAAAAAAGGACAGAGTCTATCCTCCAGGGATTGAACATTTTCCAATTAT
CTGGTCTTTTCCTGTTGTGCAAAAATGACTCATTGCTCCGAATGTCAAAAACAAATGCGACAAACAATGGCACTTCATCATTTAAAGTAA
TGTTGCCAAGAGAAAAAATTTCCTGGGAGGGAGGTTTCCCACAAGCCAAATCTCCTAAGCCTCAAATGCTAGCACTTTTTGGCAGTTGGA
TAGGAAATGAGACATTCTTTGGCAGCCAAAATAAGAGAGGCCGATGGTGAAACTTTTTGAGACACCCTATGGCCTTCTTGTCAAAACCTT
CACTGGAGCTCAAGAAAAGCATTTCTGTTGTGTTATTTGCAGTGCAGATGATGTCTGTGTAACAACATAATGGTTATTCACCTTTTTTTG
ATTTTGATTTTTGCTGTGTTATCAAAAACTTGAATACTGTGAGAAGAAGTGAATTTTCAGTTGACGAATCAGCATCTTGTTCCCATGGTG
ATAACACTAATTGAATATATCTATGAGGGCATGTATTAGTTAATGGAAAAAAAAATACAACACTAACAATACATAGCTGCAATGTGTACA
ATGGCTGATTTAATTAAATAAAATGTACAAGTGTTAAATGTGGAAAAAAAGGAAGGCGTGAGGGCGGGCAGCAGCGACAGGATGCTTGTT
TTTCGCTCTACCAAAGTCGTCTGAAGGCGAGACAGCGGGCCCAGGGCGCAGGACCCACCGCAGCCCCCTGGGCAGTCTCCTCGCCCCGCG
TCCGCGTCGTCTCCGGGGCACTTAGTAAGGGGTGGGGAGAGCTTGCCCTCCCTCTTAAGCTGAGGAGAAACACCCGAAGACACCGCAGGA
GCCTGTGAAAGTCCCTAGGACTCCAAGTGAGGAAGTGACACTCCCAGGCGAGCCGGCCCGCGGCTGCCAGTCTGCACGGCCTCGGCACGG
CGGCCCCGGAGCGGCGCGGGGTGGATCTCAGGCTCTGCCGGCCCGCGGCCCGCGGGGTCCATGCGCAGGGCCCCCAGCCCAAGTTCTTCC
ATCTTCCGATGCGGCCCCCCAGAGCCGCGGGGCAGCCGGTGATCTAGCCCGGGAGCCCATCTTACAGCGGTGCCAAGCAGAGGGGCGGCA
GAGACGGAGGGGCAGCCTCTTTGGGACTAACTCATGAAGAACAAGGGTGCTAAGCAGAAGCTGAAACGAAAGGGAGCCGCCAGCGCGTTT
GGCTGTGACCTGACGGAGTATCTGGAAAGCTCGGGACAGGATGTTCCATACGTTTTGAAGAGCTGTGCAGAATTTATAGAGACTCACGGC
ATCGTGGATGGAATCTATCGGCTTTCAGGAGTCACCTCAAACATACAACGGCTAAGGCAAGAGTTTGGCTCAGATCAATGTCCAGATCTG
ACAAGGGAAGTGTACCTCCAGGACATCCACTGTGTGGGCTCGCTTTGCAAGCTCTACTTTAGGGAGCTGCCCAACCCCCTCCTGACTTAT
GAGCTCTATGAGAAATTCACGGAGGCAGTGTCGCATTGCCCTGAAGAAGGCCAACTGGCCCGAATCCAAAATGTTATCCAGGAGCTTCCT
CCATCCCACTATAGGACCTTGGAATACCTGATTCGACACCTGGCCCATATCGCCTCCTTCAGCAGCAAGACCAACATGCACGCCCGGAAC
CTGGCCCTGGTGTGGGCGCCAAACCTCCTCAGGTCTAAAGAAATTGAAGCCACTGGTTGCAATGGAGATGCAGCCTTCCTTGCAGTCCGG
GTCCAGCAGGTGGTGATTGAGTTCATATTGAATCATGTAGATCAAATCTTTAACAACGGTGCACCTGGGTCTCTGGAGAATGATGAAAAC
CGGCCCATCATGAAGAGCCTGACCTTGCCAGCCCTCTCCCTGCCCATGAAGCTGGTGAGCCTTGAGGAAGCTCAAGCCCGCAGCCTGGCC
ACTAACCATCCTGCTCGCAAGGAAAGGAGGGAGAACAGCCTGCCTGAGATTGTCCCTCCCATGGGCACCCTCTTCCACACTGTCCTTGAG
TTACCAGACAACAAGCGAAAGCTCTCCAGTAAATCAAAGAAGTGGAAATCAATATTTAACCTGGGACGTTCTGGATCAGACTCCAAATCA
AAACTGAGTAGAAATGGGAGTGTATTTGTGAGAGGACAGAGGCTCTCGGTGGAAAAGGCTACTATCCGACCAGCTAAAAGCATGGACTCA
CTATGTTCAGTGCCTGTAGAAGGAAAAGAAACCAAGGGAAATTTCAATCGAACAGTTACCACCGGTGGATTTTTCATTCCAGCAACAAAG
ATGCACTCCACCGGCACCGGCAGCTCATGTGACCTCACCAAGCAGGAGGGCGAATGGGGCCAGGAGGGGATGCCTCCCGGGGCTGAGGGT
GGCTTTGATGTGAGCAGTGATCGCAGCCATCTCCAGGGCGCTCAGGCCCGGCCCCCACCGGAACAGCTGAAGGTTTTCCGGCCTGTTGAG
GATCCGGAGAGCGAGCAAACAGCCCCAAAGATGTTGGGTATGTTCTACACTTCGAACGACAGCCCTAGCAAATCCGTCTTCACCAGCAGC
CTCTTCCAGATGGAGCCCTCGCCGCGTAACCAGCGCAAGGCGCTGAACATCTCCGAGCCCTTTGCGGTATCTGTGCCGCTCCGCGTGTCC
GCAGTCATCAGCACCAACAGCACGCCGTGCAGAACACCCCCGAAGGAGCTGCAGTCTCTTTCCAGCCTGGAAGAGTTTTCTTTTCATGGA
TCAGAGAGCGGAGGCTGGCCAGAAGAAGAGAAACCGCTGGGAGCTGAGACTTCTGCAGCTTCTGTACCTAAGAAGGCAGGTCTTGAGGAT
GCCAAGGCAGTACCTGAAGCACCGGGGACAGTGGAATGCAGCAAAGGCCTGTCCCAGGAGCCAGGCGCCCACCTGGAGGAGAAGAAAACC
CCAGAAAGCTCCTTGAGCTCTCAACATTTAAATGAATTAGAGAAGAGGCCAAATCCGGAGAAGGTGGTGGAGGAGGGACGAGAGGCTGGT
GAGATGGAGTCCAGCACCCTGCAGGAGAGCCCCAGGGCCAGAGCCGAAGCTGTGCTTCTCCATGAGATGGATGAAGATGATCTGGCCAAT
GCCCTGATCTGGCCTGAGATTCAACAGGAGCTGAAAATCATTGAATCTGAGGAGGAGCTCTCATCGTTGCCACCTCCTGCTCTGAAGACC
AGCCCAATTCAGCCTATTCTCGAGTCGAGTCTGGGGCCCTTTATTCCCTCAGAGCCTCCTGGGAGCTTGCCTTGTGGCTCCTTCCCTGCT
CCAGTCTCCACCCCTCTGGAGGTGTGGACTAGGGATCCAGCCAATCAGAGCACACAGGGGGCTTCCACAGCAGCCAGCAGAGAGAAGCCG
GAACCTGAGCAGGGCCTGCACCCAGACCTCGCCAGCCTGGCTCCTCTGGAAATAGTTCCTTTTGAGAAGGCATCTCCACAAGCAACAGTG
GAAGTAGGAGGCCCAGGCAATCTGTCTCCTCCACTCCCACCTGCTCCTCCCCCTCCAACTCCTCTGGAGGAGTCAACTCCAGTCCTGCTT
TCAAAGGGCGGCCCGGAAAGAGAAGACTCATCCAGGAAATTGAGGACAGATCTCTACATAGACCAGCTGAAGTCCCAAGACAGCCCTGAG
ATCTCTAGCCTCTGTCAGGGAGAGGAGGCAACCCCAAGACACAGTGACAAGCAAAATTCAAAGAATGCTGCTTCTGAGGGGAAAGGCTGT
GGTTTTCCAAGCCCAACCAGGGAGGTTGAGATCGTCTCACAAGAAGAGGAGGATGTAACCCATTCAGTACAGGAGCCTTCAGACTGTGAC
GAAGATGACACTGTGACAGACATTGCCCAGCATGGCCTGGAGATGGTGGAGCCCTGGGAGGAACCCCAGTGGGTGACGAGTCCCCTTCAC
TCTCCCACCCTGAAAGACGCGCACAAGGCCCAGGTACAGGGCCTTCAGGGTCACCAGTTGGAGAAGAGGCTTTCCCACAGGCCCAGCCTT
CGCCAGAGCCATTCTCTAGATAGCAAACCCACGGTTAAAAGCCAGTGGACTCTCGAGGTTCCCTCCTCCAGCAGCTGTGCTAATCTTGAA
ACAGAGAGGAATTCTGACCCTCTTCAGCCCCAGGCACCCAGGAGAGAGATTACTGGATGGGATGAGAAAGCCCTGAGGTCCTTCAGAGAG
TTCTCTGGCCTGAAAGGGGCAGAGGCTCCTCCCAACCAGAAGGGACCAAGTGGTGTGCAACCCAACCCAGCAGAAACCAGCCCCATCAGC
CTAGCAGAGGGAAAGGAGCTAGGGACACACCTGGGGCACAGCAGTCCACAGATTAGGCAAGGTGGTGTTCCTGGGCCAGAGAGCAGCAAG
GAGAGTTCACCCAGCGTGCAGGACAGCACTTCGCCTGGAGAGCACCCCGCAAAGTTACAGCTAAAGAGCACAGAGTGTGGGCCCCCAAAA
GGGAAAAACAGGCCTTCTTCCCTCAACTTGGACCCTGCCATTCCCATTGCTGACCTCTTCTGGTTTGAGAATGTGGCCTCATTTAGTTCA
CCTGGAATGCAGGTCTCTGAGCCAGGAGACCCAAAGGTCACATGGATGACCTCATCTTACTGTAAAGCAGACCCCTGGAGGGTTTACTCC
CAGGACCCCCAGGACCTGGACATTGTTGCTCATGCACTGACAGGCCGCCGTAACTCAGCTCCTGTGAGTGTGTCAGCTGTGAGAACCTCC
TTCATGGTCAAAATGTGCCAGGCCAGGGCGGTCCCAGTCATCCCTCCCAAGATTCAGTACACCCAGATCCCACAGCCCCTGCCCTCTCAG
AGCTCAGGGGAGAATGGGGTTCAGCCTCTGGAGAGGAGCCAGGAGGGACCCAGCTCAACCAGTGGGACCACTCAGAAACCTGCCAAAGAT
GATTCTCCCTCCTCCCTGGAAAGCTCAAAGGAAGAAAAACCAAAGCAAGATCCCGGAGCCATTAAGTCCTCACCAGTGGATGCCACTGCA
CCCTGCATGTGCGAGGGACCTACCCTTTCTCCAGAACCAGGCTCGTCTAACCTGCTCTCCACCCAGGATGCAGTAGTGCAATGCAGAAAG
CGCATGTCAGAGACAGAGCCATCTGGGGACAACCTTCTTTCTTCAAAACTAGAGCGACCATCTGGGGGTTCTAAGCCTTTCCACAGGTCA
AGGCCAGGAAGACCTCAGAGCCTAATCTTATTCAGTCCTCCTTTCCCCATTATGGACCACCTGCCCCCTTCATCCACAGTGACAGATTCC
AAGGTCCTGCTGTCCCCTATCAGAAGTCCCACCCAGACAGTTTCCCCTGGCCTTCTTTGTGGAGAGTTGGCAGAAAACACATGGGTCACA
CCAGAAGGGGTTACACTTAGGAATAAAATGACCATCCCTAAGAATGGCCAGAGACTAGAGACCTCAACCAGCTGTTTTTACCAGCCTCAG
CGGAGATCAGTAATTCTGGATGGAAGAAGTGGGAGGCAAATAGAATGATTTCGGTTCACCTGCTGGTGTCTGAAAAAAACCGTGATTCAT
CTGGAAGTTATTACAGGGCCAGCTTGCCATATTCCAGGCACACGTTATCAAGTTTGGGCCTATTGTGGCCTCTGACTTCTCTTTCTTCAG
CCTTTTGACCACTTATTAATTAGTCCATTTGCTAGAAGAGTGGTCAAGGGAAAAACGAGAGATGAAATTTAGTTAAGTCTATGTGAGCAA
GTGAGAGAAGGTTAGGTAAGGGGAGAGGATGGAATGCTTGCCTCCAATGAACTTTGGAGCTTGTATGTGAGTCAGATTGCTCCCCTATTG
CTATTATCTATTACTCTTGAGAGCTGGCTGTCCTTTGAAAGAAAGAAGTAATGTTCTTTGAAAGAAAGAAAAATCTCTTGCTGTGTCAAA
CCTCAAAATGTTGCTATTGGGGTTAGAAGGCCTCCTCTTTATGCTTTTTAATGCTCTTTCAAACGTGTTCTTTTAGACCAGTTTTCTAAT
AAGCTTTGTAAAATGTACTATCCAAATTAGAAGCGGATTTGGAAATGCAAACTAACGTGCACTTAGATATCCAAGTGGGTGAGCTTAGCC
ACTCTTACCCATGCTCTTTCCCTGGAATCCCTGGAGACCTGTCCAAGATGATTTCCATATACCAGCATAGAAAATCAGAATCAAGAGCAA
ACTCTGAGACTGGCACAATCCAAGAAGATTTCCTGGCTCTGGCTTTTAGTAATTTGGGACTCCAACTGCCACTGTACTGGACTGTAATTT
ATAAATCCAGTAGCTACGCAGGGTGGAGGCTGGGCTGAGGATTACCATAATGAAATGTACTAAATCTTCATTTAGGTATGCAATTGTGAA
GTGAAGGCATCTGCTTTCTTTACAGTATCAGAGTCCAAGAACAGGATGTCACCATAGATAAAAGCCTCATACAAAGGCAGAACTACACTC
CAAATTTAATGTGTTTAAATTGGTGGGGCACCAGCAGAAAATATTCTAGCTCAGCTTTACTCTTCTTCCACACTAGGCTGGGCCCAGCAA
TACAGGAGAGGATGAAGGGAGGAGCTCCAGGAGGCGAGGGAAGAGCCCTAGCAGGGCGGCCATCACAACCACTCACTGAGAGTTGCCCTT
CTTAAAAATGTATTTTATTTTAGCCAGTGGGTCCCTTCCTTTCTCCTTTCCTCTCTACTGCTCAAGAACAGATTTGAGGCCAGGTGCGGT
GCCTCACATCTGTAATCCCAACACTTTGGGAGGCTGAGATGGGTGGATTGCTTGAGCCCAGGAGTTCAAGACCAGCCTGGGCAACACAGC
GAGACCCCATCTCTTAAAAAATAACAGACTTGAGGAACCCCTCTCCCTTCCATAATTCCCCTCATCCACCGCCCACTCCAGGCACTCACT
CAAACTTGCTCTTCAACTCTGTATACAAGCAGAAGCAATAAACCAATCTGATTTTCTTTTCAATTATTTATAACTTTCAATGGTTCTTTC
CTTTCCAGCTGGCGAGAGAAAGGAGAACTAATATACCTGCTGGCAGATTTTTGGTGCTGCCCAAAAAAGGACTTCACAGGGCATCTCTTC
TCAGGTTCAAGCCTGGCTGAATTCTGCCCAGAAGCTCAGTCATTGCAGAAATTTCTCTAAGGGCTGATAGTACCTCTGGGTAGGCGTCAC
AACCAAGGCTGGTTCTGGGCTTAGTGGGGGCTGAGATGAAGTTACCTCCTCCAATGAGAAATTGGGAGCTGATGCCCTGCAACAGATATA
TATTCCTCTCTCTCTCTGTCTCTCTATCTCTCTCCTCCCTCTCCCTCCCTCCCTCCCCGCCAATAAGCCTTACAAACAGTTTTGAAATCT
TGTTCTGTACCTTTTAAGCCAGTGTCTGTGGCGAGGGTGACTGGCAAGTCAGCTGATGAGTTCTGCCTTCTGAGAGCACTGAGTGAGCAA
GGCCTTTCATCAGTGTTTTGGCCTTCTCATTGGGTGAGGAAGACATTGAACCAACAGCCAACGAGATATGAACCTGTAAGAAAAAAGTCC
TAGAATATAGTATTTTTCCCCAGGCCAGCAAAGTGAAGAAATACAGTGGTGACAGATGAGAAAGGCCATGTTCAAGAGATCTGAAAAGTA
CATTCCTGCCTTATCAGAAAATGTGTCAGACAGGTTTTATGTCAGCCTCAGTGCTCCTGCGGTGTCGACGCTCTGATAAGGACCATGTTC
CAGTTAGAATGCGAGGGAGGGAAAGAGCTGCACTTTGCTTCACCATCAGAACTCTGAGCCAAATAATGAATATGTAAACTATTTTATGAT
TATTTTAAATGTTTGTTTGGTAACATTTATAAGATCTATTTTTATTTGGGGATAGACTGAGAAGCCACCATTTACATATTAACAAGTGAC
TTCAGTTCTAAGGGTTGAGATGCCTGTGTGGATTTATAAAATGGTTGCAAGATCTTTTAGACTCTGACATTTATAGCATCACCTTCAGGA
ACACAGTTCTGGGGATGTCATCATGAGACACACTGACAGCTGTGGAGATAGTCCCTACTCTCAGCTTTCCTTGCTAGTCAAGTCCAAAAG
GCCTTAGAAGCTGACTCACCTTCTCAGCCAGAGTCCTGCTGCTCAAGTGTGGACCTCCACTTTGACTCTCACCCAGCCTGCCAGCCATCA
CAAAGGCTTTCATAAACTTCCTGTGGTCTGGGCTAGCCTGGCACTGATGAAATTCCATTCTAAAGAAAGAAAACTCATATTCCTCCCCCC
CACAAATTGTTCCCCCAAATGCTCTGGGATTACCTATTTCACCACTCATTTGAGTCTCCGAAAAATGAACTCCCTGAGAATGGCTGGATG
GGAATCAGATAGTCTGCTTCCATTCAGGAGAGGGACAGAACAGGAGCTGCTGTGTTTAGGAGGATTTACCTGGTGCCCTAGAAAGGGCTA
TGCAATCAAATTCTCAAGGGCTCCTTCAAATCAGCTATCAGTCCTCAAAATGGGGGTTGCTGATGTTAAATGATGGATTTGCAGTGAAAC
GCATGCATGTACTGACGTTTTCTTTCAGCATTAGTGGTTGCTTAAGAAAATAGTAACCTATATTTTCTGCTACACTTGGAATATGAAGAA
ATCTGAACAAGAACCCCATTAAGACACCTAACCTAATCTAAACCCTAAAATTCAAAATATTGTCCAAGTCAAAAGTCTAGACTCTGAGGA
CATTAAAAATGTAAATATCATCATCCTTAGCAAATATTTATTGGGAGCTTAGTAATAGTGCACTGGGTACCTTAGCACTCCCAAATCATT
CAAGAGTCTAGTGAAAAAGGGGGAGGGATGGCAGCAAATAAAACACCCCCATAAACAACCAGGAGCAAGGTTGAGAACCATTAAGTTGCC
AAACAAAAGCAGAAGGGGAAAAAGTGTGGCAACAAGCATCTTTTAATAGGATAGTTGACGGTATTCAAGTGACCTACTGACTCCAAATAA
TCAAATTGAACACAATTGCAAATCCAATAGAACATCCCAGTGAGACACTCGGGTATTTGAGAACTTTGCTTGATTTAGAAAACTGGAAAG
TGGCAACTAGGCTAGAATAGTGGCAACTAGGTTCGGAGGTTTCGTGTGGTCATAATTGGTTTGGTGAAGTGTGAGATCTCTGCAAATGAG
CCAGGTAAGATCAGTATTCCATAGTGCTTGAAAAGGGGATTTTAGAGACTTCTGTCATCACAAAGCAGATTAACTCCTAGTTAATGATGA
AGCAGTAGGCCCAAGATAAACTGTTCAATTCAAGATAAATTGTTCTTGTCAGTGTTTGGCATATGATAATCACATTTGGCTAAAATTGGA
TGGGACAGTCATTTGTCTACACAGGCCTTCCATTCCTGCATGAAGAGATACTGGGGAGCATACAATTATTTTGTCCAGTATTAGAGTGGG
AGAAGTTCTCAGTAAGTCCAGTCCCACCAGGATTTATTTGGGCCACATTCTACCACGGCCAGTCCAATCTGATGACCACATGAATTGGGG
TTAAGTGTTGCTAAGACTATGATTTTAGACATGTCTGGCAGGAAGGTCAGCTCAAAATGTGGCATGACAAAGAATATGTGCTCTACTACC
AAAACCTTTCCTAGCAAAACAAGGCCAGAAGAGGGAGCAAGCATCTTTCCAAGCATGGAGAGGAGGGGGCAATGGTGGAAGGGTGATTGC
CTGAAATCAGTGCCAGTACAGATAGCATAAAATTGGGGGCCACCACAGATTGGCTGGCTACTGTGTAGATCATTTAGTAATCTTGAGGTA
CATTAATAATGCAGAGATTACTTTTCTGTGAGGGTAAGGGGGACGTAGCTAAATATAAGAAGCTTACAAGGTCCATAGCCATGTATTTTA
CTGGATAAATCACAATGCTTTGCAATAACTTAATGTCATAGTACTTTCTGGCTTATAATTCTGCAAAGTAAAGCACTTTTTCAAAGGA

>4354_4354_1_ANK2-ARHGAP31_ANK2_chr4_114304891_ENST00000506722_ARHGAP31_chr3_119013220_ENST00000264245_length(amino acids)=1892AA_BP=
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQE
LLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQ
QGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFT
ARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLL
QHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMG
HLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYT
PLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASP
HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD
ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK
RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTMTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLE
GGRSDSLRSFSSDRSHTLSHASYLRDSAVMDDSVVIPSHQVSTLAKEAERNSYRLSWGTENLDNVALSSSPIHSGRASPCLERDNSSFLV
SFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGKLHLPTAPPPLNEGESLV
SRILQLGPPGTKFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQY
FAVVSRIKQDSNLIGPEGGVLSSTVVPQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVP
KASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVTFASQVYREIICVPYMAKF
VVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFAEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDT
TQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYTKESESDQEQEEEIDMTSEKNPQDEQERIEERLAYIADHLGFSWTELARELDFTE
EQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTNLVECLTKINRMDIVHLMETNTEPLQERISHSYAEIEQTITLDHSEGFSVLQEE
LCTAQHKQKEEQAVSKESETCDHPPIVSEEDISVGYSTFQDGVPKTEGDSSATALFPQTHKEQVQQDFSGKMQDLPEESSLEYQQEYFVT
TPGTETSETQKAMIVPSSPSKTPEEVSTPAEEEKLYLQTPTSSERGGSPIIQEPEEPSEHREESSPRKTSLVIVESADNQPETCERLDED
AAFEKGDDMPEIPPETVTEEEYIDEHGHTVVKKVTRKIIRRYVSSEGTEKEEIMVQGMPQEPVNIEEGDGYSKVIKRVVLKSDTEQSEDN
NE

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Fusion Gene PPI Analysis for ANK2-ARHGAP31


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneANK2chr4:114304891chr3:119013220ENST00000357077-4646966_11254714.3333333333333958.0SPTBN1
HgeneANK2chr4:114304891chr3:119013220ENST00000506722-4747966_11252618.66666666666651864.0SPTBN1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANK2chr4:114304891chr3:119013220ENST00000394537-145966_112501873.0SPTBN1
HgeneANK2chr4:114304891chr3:119013220ENST00000510275-114966_11250556.0SPTBN1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANK2-ARHGAP31


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANK2-ARHGAP31


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK2C1970119CARDIAC ARRHYTHMIA, ANKYRIN-B-RELATED5CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneANK2C1142166Brugada Syndrome (disorder)4CLINGEN
HgeneANK2C0035828Romano-Ward Syndrome3ORPHANET
HgeneANK2C0038454Cerebrovascular accident1CTD_human
HgeneANK2C0751956Acute Cerebrovascular Accidents1CTD_human
HgeneANK2C1535926Neurodevelopmental Disorders1CTD_human
TgeneC4551482Adams-Oliver syndrome 14CTD_human;GENOMICS_ENGLAND
TgeneC0265268Adams Oliver syndrome1ORPHANET