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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANK3-MCU (FusionGDB2 ID:HG288TG90550)

Fusion Gene Summary for ANK3-MCU

check button Fusion gene summary
Fusion gene informationFusion gene name: ANK3-MCU
Fusion gene ID: hg288tg90550
HgeneTgene
Gene symbol

ANK3

MCU

Gene ID

288

90550

Gene nameankyrin 3mitochondrial calcium uniporter
SynonymsANKYRIN-G|MRT37C10orf42|CCDC109A|HsMCU
Cytomap('ANK3')('MCU')

10q21.2

10q22.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)calcium uniporter protein, mitochondrialcoiled-coil domain-containing protein 109A
Modification date2020031320200313
UniProtAcc

Q12955

.
Ensembl transtripts involved in fusion geneENST00000373827, ENST00000510382, 
ENST00000280772, ENST00000355288, 
ENST00000460468, ENST00000503366, 
Fusion gene scores* DoF score28 X 22 X 9=55447 X 5 X 5=175
# samples 297
** MAII scorelog2(29/5544*10)=-4.25680245212228
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANK3 [Title/Abstract] AND MCU [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANK3(62374944)-MCU(74594117), # samples:2
Anticipated loss of major functional domain due to fusion event.ANK3-MCU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-MCU seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-MCU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-MCU seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMCU

GO:0006851

mitochondrial calcium ion transmembrane transport

21685888|24560927

TgeneMCU

GO:0019722

calcium-mediated signaling

21685886|21685888

TgeneMCU

GO:0036444

calcium import into the mitochondrion

22925203

TgeneMCU

GO:0051259

protein complex oligomerization

21685886

TgeneMCU

GO:0051561

positive regulation of mitochondrial calcium ion concentration

21685888|24560927


check buttonFusion gene breakpoints across ANK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MCU (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCSTCGA-NF-A5CP-01AANK3chr10

62374944

-MCUchr10

74594117

+


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Fusion Gene ORF analysis for ANK3-MCU

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373827ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-3CDSENST00000510382ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
5UTR-intronENST00000510382ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
In-frameENST00000373827ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000280772ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000280772ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000280772ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000355288ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000460468ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000357157ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000373053ANK3chr10

62374944

-MCUchr10

74594117

+
intron-3CDSENST00000503366ENST00000536019ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000280772ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000355288ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000460468ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+
intron-intronENST00000503366ENST00000605416ANK3chr10

62374944

-MCUchr10

74594117

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373827ANK3chr1062374944-ENST00000373053MCUchr1074594117+3045267241172382
ENST00000373827ANK3chr1062374944-ENST00000357157MCUchr1074594117+2982267241109361
ENST00000373827ANK3chr1062374944-ENST00000536019MCUchr1074594117+3043267241172382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373827ENST00000373053ANK3chr1062374944-MCUchr1074594117+0.0006129780.999387
ENST00000373827ENST00000357157ANK3chr1062374944-MCUchr1074594117+0.0005581080.9994419
ENST00000373827ENST00000536019ANK3chr1062374944-MCUchr1074594117+0.0006073280.9993926

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Fusion Genomic Features for ANK3-MCU


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANK3chr1062374943-MCUchr1074594116+0.0007911490.99920887
ANK3chr1062374943-MCUchr1074594116+0.0007911490.99920887

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANK3-MCU


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:62374944/chr10:74594117)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

.
FUNCTION: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {ECO:0000250, ECO:0000269|PubMed:17974005}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708192_22350331.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708311_33950331.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308192_22350352.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308311_33950352.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908192_2231303.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908311_3391303.0Coiled coilOntology_term=ECO:0000255
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708216_23450331.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708283_29250331.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr10:62374944chr10:74594117ENST000003571570875_16550331.0RegionN-terminal MCU domain
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308216_23450352.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308283_29250352.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr10:62374944chr10:74594117ENST000003730530875_16550352.0RegionN-terminal MCU domain
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908216_2341303.0RegionOuter juxtamembrane helix (OJMH)
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908283_2921303.0RegionInner juxtamembrane helix (IJMH)
TgeneMCUchr10:62374944chr10:74594117ENST000005360190875_1651303.0RegionN-terminal MCU domain
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708257_26550331.0Topological domainMitochondrial intermembrane
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708284_35150331.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST000003571570851_23350331.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308257_26550352.0Topological domainMitochondrial intermembrane
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308284_35150352.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST000003730530851_23350352.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908257_2651303.0Topological domainMitochondrial intermembrane
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908284_3511303.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST000005360190851_2331303.0Topological domainMitochondrial matrix
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708234_25650331.0TransmembraneHelical
TgeneMCUchr10:62374944chr10:74594117ENST0000035715708266_28350331.0TransmembraneHelical
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308234_25650352.0TransmembraneHelical
TgeneMCUchr10:62374944chr10:74594117ENST0000037305308266_28350352.0TransmembraneHelical
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908234_2561303.0TransmembraneHelical
TgeneMCUchr10:62374944chr10:74594117ENST0000053601908266_2831303.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1441519_189805447.666666666667Compositional biasNote=Ser-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1442247_225005447.666666666667Compositional biasNote=Poly-Thr
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1442393_239605447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1443205_321105447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1443255_325905447.666666666667Compositional biasNote=Poly-Pro
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1443482_348705447.666666666667Compositional biasNote=Poly-Ser
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1443785_379105447.666666666667Compositional biasNote=Poly-Asn
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1443957_398105447.666666666667Compositional biasNote=Thr-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1211519_18980814.0Compositional biasNote=Ser-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1212247_22500814.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1212393_23960814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1213205_32110814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1213255_32590814.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1213482_34870814.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1213785_37910814.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1213957_39810814.0Compositional biasNote=Thr-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2441519_1898322277.6666666666665Compositional biasNote=Ser-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2442247_2250322277.6666666666665Compositional biasNote=Poly-Thr
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2442393_2396322277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2443205_3211322277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2443255_3259322277.6666666666665Compositional biasNote=Poly-Pro
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2443482_3487322277.6666666666665Compositional biasNote=Poly-Ser
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2443785_3791322277.6666666666665Compositional biasNote=Poly-Asn
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2443957_3981322277.6666666666665Compositional biasNote=Thr-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1441519_189801808.0Compositional biasNote=Ser-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1442247_225001808.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1442393_239601808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1443205_321101808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1443255_325901808.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1443482_348701808.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1443785_379101808.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1443957_398101808.0Compositional biasNote=Thr-rich
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1441141_128805447.666666666667DomainZU5 2
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1444090_417405447.666666666667DomainDeath
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144984_113905447.666666666667DomainZU5 1
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1211141_12880814.0DomainZU5 2
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1214090_41740814.0DomainDeath
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121984_11390814.0DomainZU5 1
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2441141_1288322277.6666666666665DomainZU5 2
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2444090_4174322277.6666666666665DomainDeath
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244984_1139322277.6666666666665DomainZU5 1
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1441141_128801808.0DomainZU5 2
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1444090_417401808.0DomainDeath
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144984_113901808.0DomainZU5 1
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-1441273_140705447.666666666667RegionUPA domain
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-1211273_14070814.0RegionUPA domain
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-2441273_1407322277.6666666666665RegionUPA domain
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-1441273_140701808.0RegionUPA domain
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144106_13505447.666666666667RepeatNote=ANK 2
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144139_16805447.666666666667RepeatNote=ANK 3
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144172_20105447.666666666667RepeatNote=ANK 4
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144203_23005447.666666666667RepeatNote=ANK 5
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144234_26305447.666666666667RepeatNote=ANK 6
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144267_29605447.666666666667RepeatNote=ANK 7
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144300_32905447.666666666667RepeatNote=ANK 8
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144333_36205447.666666666667RepeatNote=ANK 9
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144366_39505447.666666666667RepeatNote=ANK 10
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144399_42805447.666666666667RepeatNote=ANK 11
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144432_46105447.666666666667RepeatNote=ANK 12
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144465_49405447.666666666667RepeatNote=ANK 13
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144498_52705447.666666666667RepeatNote=ANK 14
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144531_56005447.666666666667RepeatNote=ANK 15
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144564_59305447.666666666667RepeatNote=ANK 16
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144597_62605447.666666666667RepeatNote=ANK 17
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144630_65905447.666666666667RepeatNote=ANK 18
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144663_69205447.666666666667RepeatNote=ANK 19
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144696_72505447.666666666667RepeatNote=ANK 20
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144729_75805447.666666666667RepeatNote=ANK 21
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-14473_10205447.666666666667RepeatNote=ANK 1
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144762_79105447.666666666667RepeatNote=ANK 22
HgeneANK3chr10:62374944chr10:74594117ENST00000280772-144795_82505447.666666666667RepeatNote=ANK 23
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121106_1350814.0RepeatNote=ANK 2
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121139_1680814.0RepeatNote=ANK 3
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121172_2010814.0RepeatNote=ANK 4
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121203_2300814.0RepeatNote=ANK 5
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121234_2630814.0RepeatNote=ANK 6
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121267_2960814.0RepeatNote=ANK 7
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121300_3290814.0RepeatNote=ANK 8
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121333_3620814.0RepeatNote=ANK 9
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121366_3950814.0RepeatNote=ANK 10
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121399_4280814.0RepeatNote=ANK 11
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121432_4610814.0RepeatNote=ANK 12
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121465_4940814.0RepeatNote=ANK 13
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121498_5270814.0RepeatNote=ANK 14
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121531_5600814.0RepeatNote=ANK 15
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121564_5930814.0RepeatNote=ANK 16
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121597_6260814.0RepeatNote=ANK 17
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121630_6590814.0RepeatNote=ANK 18
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121663_6920814.0RepeatNote=ANK 19
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121696_7250814.0RepeatNote=ANK 20
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121729_7580814.0RepeatNote=ANK 21
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-12173_1020814.0RepeatNote=ANK 1
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121762_7910814.0RepeatNote=ANK 22
HgeneANK3chr10:62374944chr10:74594117ENST00000355288-121795_8250814.0RepeatNote=ANK 23
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244106_135322277.6666666666665RepeatNote=ANK 2
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244139_168322277.6666666666665RepeatNote=ANK 3
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244172_201322277.6666666666665RepeatNote=ANK 4
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244203_230322277.6666666666665RepeatNote=ANK 5
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244234_263322277.6666666666665RepeatNote=ANK 6
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244267_296322277.6666666666665RepeatNote=ANK 7
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244300_329322277.6666666666665RepeatNote=ANK 8
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244333_362322277.6666666666665RepeatNote=ANK 9
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244366_395322277.6666666666665RepeatNote=ANK 10
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244399_428322277.6666666666665RepeatNote=ANK 11
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244432_461322277.6666666666665RepeatNote=ANK 12
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244465_494322277.6666666666665RepeatNote=ANK 13
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244498_527322277.6666666666665RepeatNote=ANK 14
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244531_560322277.6666666666665RepeatNote=ANK 15
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244564_593322277.6666666666665RepeatNote=ANK 16
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244597_626322277.6666666666665RepeatNote=ANK 17
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244630_659322277.6666666666665RepeatNote=ANK 18
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244663_692322277.6666666666665RepeatNote=ANK 19
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244696_725322277.6666666666665RepeatNote=ANK 20
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244729_758322277.6666666666665RepeatNote=ANK 21
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-24473_102322277.6666666666665RepeatNote=ANK 1
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244762_791322277.6666666666665RepeatNote=ANK 22
HgeneANK3chr10:62374944chr10:74594117ENST00000373827-244795_825322277.6666666666665RepeatNote=ANK 23
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144106_13501808.0RepeatNote=ANK 2
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144139_16801808.0RepeatNote=ANK 3
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144172_20101808.0RepeatNote=ANK 4
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144203_23001808.0RepeatNote=ANK 5
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144234_26301808.0RepeatNote=ANK 6
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144267_29601808.0RepeatNote=ANK 7
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144300_32901808.0RepeatNote=ANK 8
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144333_36201808.0RepeatNote=ANK 9
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144366_39501808.0RepeatNote=ANK 10
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144399_42801808.0RepeatNote=ANK 11
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144432_46101808.0RepeatNote=ANK 12
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144465_49401808.0RepeatNote=ANK 13
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144498_52701808.0RepeatNote=ANK 14
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144531_56001808.0RepeatNote=ANK 15
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144564_59301808.0RepeatNote=ANK 16
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144597_62601808.0RepeatNote=ANK 17
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144630_65901808.0RepeatNote=ANK 18
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144663_69201808.0RepeatNote=ANK 19
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144696_72501808.0RepeatNote=ANK 20
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144729_75801808.0RepeatNote=ANK 21
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-14473_10201808.0RepeatNote=ANK 1
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144762_79101808.0RepeatNote=ANK 22
HgeneANK3chr10:62374944chr10:74594117ENST00000503366-144795_82501808.0RepeatNote=ANK 23


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Fusion Gene Sequence for ANK3-MCU


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4378_4378_1_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000357157_length(transcript)=2982nt_BP=267nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGTAGAGATGGGGTTTTGC
CATGTTGGCCAGAATGGTTTTGAACTCCTGACCTCAAGTTATCTACCTGCCTCAGCCTCCCAAAGTGCCGAGATTATAGCCGTACGAATT
GAGATTAGCAGAAAAGCTGAGAAGAGGACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGG
CTTACCTGGTGGGAATATTCCTGGGACATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTT
GTAATGACACGCCAGGAATATGTTTATCCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTT
GACCTAGAGAAATACAATCAACTCAAGGATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTG
CCTCTCCGACAAATTGGTGAAAAAGATTGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGC
ATTGCAGGTGGAAGCTGGGAGCCATGTGGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAG
GGAATGTTAAAACCTGAGGATCAGGCATTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGG
ATGAAAATGATGCAGTTATATAGTTGAGAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCA
GCAAAAGAGTAACACACCAGCACCCCACTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATAC
TAGAAAAGCAAATTCTCATGATATGCTAAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTC
CTTCCAGCATCCCTTTACTGACCACCTACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTT
TAATAATTGACACTTTAGATTATCTCTTAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCA
ACACTGCATGAGGTTGTTGGTTTTGTTTTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTG
ATAATCCCCTCTCCCTCCAGAACACAAATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATT
GGCTAAGAATCATGGCTCTGTAGCCATTTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATG
GGACTGCCTTGTCTGGAGGCTTTGTTCATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGT
AAATCAAGTGTGTGGATCTCAAAGGGTGCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCT
ATTTTTTCTTATCTTAAATTGAGAGAAAGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCT
TGAAGAGTCAAAGGAATCTGTGTCTAATATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTG
ATTGGCCTTTTCTTTCACGTGATTCATCCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTAT
GAAAAGAAAAACTTTAAATGACAAACCCAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCC
TGCCAACACCCCTTTCATTGGCATGACGGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCAC
CCCCAGTCGTCAGCTCCTTCCCTCATTTATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTT
AAGAAGAAACAGCACAGTGCAACGAGCAAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAA
ATAGCAAACTATTGAACATGTGTAAAATCCTGTATCATTTATGAAATATGTATAAAAAGCAATGTACCTTCTGGAACAATAAATACTTAT

>4378_4378_1_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000357157_length(amino acids)=361AA_BP=81
MGGRRGAALGVPEPRPNFFPRSPTFGGPRSGTGRRDWSSWKEQQQQPHNMASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQ
NLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDF
KLVINDLTYHVRPPKRVEMGFCHVGQNGFELLTSSYLPASASQSAEIIAVRIEISRKAEKRTTLVLWGGLAYMATQFGILARLTWWEYSW
DIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEK

--------------------------------------------------------------
>4378_4378_2_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000373053_length(transcript)=3045nt_BP=267nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAA
AATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGG
GAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGG
ACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGAC
ATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTAT
CCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAG
GATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGAT
TGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGT
GGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCA
TTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGA
GAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCA
CTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCT
AAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCT
ACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCT
TAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTT
TTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAA
ATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCAT
TTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTC
ATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGT
GCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAA
AGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAA
TATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCAT
CCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACC
CAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGAC
GGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATT
TATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGC
AAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAA

>4378_4378_2_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000373053_length(amino acids)=382AA_BP=81
MGGRRGAALGVPEPRPNFFPRSPTFGGPRSGTGRRDWSSWKEQQQQPHNMASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQ
NLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDF
KLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGG
LAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEM

--------------------------------------------------------------
>4378_4378_3_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000536019_length(transcript)=3043nt_BP=267nt
ACAGCAGGAGGAGGATAGGCCGCGCTGGGCGGGCGTCGCGGGGCCGCGCTTGGTGTTCCTGAGCCGCGGCCGAACTTTTTCCCAAGAAGT
CCCACGTTTGGAGGCCCGAGGAGCGGGACGGGGAGGAGAGACTGGAGTTCCTGGAAGGAGCAGCAGCAGCAGCCCCACAACATGGCCTCC
TCCGCCTCCTCCTCTCCCGCGGGCACCGAGGACTCCGCTCCTGCCCAGGGTGGCTTTGGATCAGATTATTCACGAAGCTCTAGAAAGGTA
CACCAGAGGATCGCTTCCTGGCAGAATTTGGGAGCTGTTTATTGCAGCACTGTTGTGCCCTCTGATGATGTTACAGTGGTTTATCAAAAT
GGGTTACCTGTGATATCTGTGAGGCTACCATCCCGGCGTGAACGCTGTCAGTTCACACTCAAGCCTATCTCTGACTCTGTTGGTGTATTT
TTACGACAACTGCAAGAAGAGGATCGGGGAATTGACAGAGTTGCTATCTATTCACCAGATGGTGTTCGCGTTGCTGCTTCAACAGGAATA
GACCTCCTCCTCCTTGATGACTTTAAGCTGGTCATTAATGACTTAACATACCACGTACGACCACCAAAAAGAGACCTCTTAAGTCATGAA
AATGCAGCAACGCTGAATGATGTAAAGACATTGGTCCAGCAACTATACACCACACTGTGCATTGAGCAGCACCAGTTAAACAAGGAAAGG
GAGCTTATTGAAAGACTAGAGGATCTCAAAGAGCAGCTGGCTCCCCTGGAAAAGGTACGAATTGAGATTAGCAGAAAAGCTGAGAAGAGG
ACCACTTTGGTGCTATGGGGTGGCCTTGCCTACATGGCCACACAGTTTGGCATTTTGGCCCGGCTTACCTGGTGGGAATATTCCTGGGAC
ATCATGGAGCCAGTAACATACTTCATCACTTATGGAAGTGCCATGGCAATGTATGCATATTTTGTAATGACACGCCAGGAATATGTTTAT
CCAGAAGCCAGAGACAGACAATACTTACTATTTTTCCATAAAGGAGCCAAAAAGTCACGTTTTGACCTAGAGAAATACAATCAACTCAAG
GATGCAATTGCTCAGGCAGAAATGGACCTTAAGAGACTGAGAGACCCATTACAAGTACATCTGCCTCTCCGACAAATTGGTGAAAAAGAT
TGATCTGCAAAAAGCCTCTGAATCCTGGCAGAAGGAACACCTGTTTGCCTTTTTAATTAAAGCATTGCAGGTGGAAGCTGGGAGCCATGT
GGGGGGTAGAGCGTTTTTACCTTTAATTATAAAACAAAAACAGAAAGGATCTGAGGGAAGAAGGGAATGTTAAAACCTGAGGATCAGGCA
TTGTGGAATATAAGCTCAAAGGGCTTAGTGAATATTGTCTTAACCAAGTATCTCAGTTTCTGGATGAAAATGATGCAGTTATATAGTTGA
GAGATTCATAAAGAGAAAACAATGCTGGGGGTGTTCGTTTCTTGCATCTTCTTTGCAGAGTCAGCAAAAGAGTAACACACCAGCACCCCA
CTCGACTCTATTTGTTTTTAATTTAACTGTCCCTATTTTTGACATAGGAGTAAATAAATATACTAGAAAAGCAAATTCTCATGATATGCT
AAAATATCATTAGCATTTATTTTAAATTGGACCCAGTCTCTGCAGAGTTACCAGGAATCTTTCCTTCCAGCATCCCTTTACTGACCACCT
ACCTGTACCTCTTGGTTACACTCATTTTTTCCATTTGATAATTGGAACCAACTTATAACTGTTTAATAATTGACACTTTAGATTATCTCT
TAATACCTTCTTAAATGTCTATATATCCCAGTGCTCTGGATCAGTGTCTAAAAATCACTGGCAACACTGCATGAGGTTGTTGGTTTTGTT
TTGTTTTATTAATTAGTCTTTCACAGGAGGAATAATTGCCCTCCTTTATATACTTATCTATTGATAATCCCCTCTCCCTCCAGAACACAA
ATCAGAGGGAAAGGGGGTGTTCAGCTGTACTACCAAATCAGGAAGATGTAAGGTTTACAAATTGGCTAAGAATCATGGCTCTGTAGCCAT
TTCAACCAGAATAATTTTATTGCTAATCTGCTTTGTGTGACAGCATTCCAGGCCAGCCAGATGGGACTGCCTTGTCTGGAGGCTTTGTTC
ATCTCGAAGGACACACACTTCCACACTGTTTGTGAGCCCTCCCACCTCCACAACTTCAGTTGTAAATCAAGTGTGTGGATCTCAAAGGGT
GCAATTTATCTTTATATAGGAATACATTTCTAGGGCTTCCTTCAAGCCCACTCTCTTCACCCTATTTTTTCTTATCTTAAATTGAGAGAA
AGAGAATTAATCTTATACTTTGTCAAAACATTTTCTACCATATTTCCAGATGACATCTGCGCTTGAAGAGTCAAAGGAATCTGTGTCTAA
TATCCTGTTTTTAACTGCTGTAGGGGCAGGATGGAAAGGATGATGGGGGCTGCCACACCACTGATTGGCCTTTTCTTTCACGTGATTCAT
CCTTCCTCATTGTGGCAAGGAGTTTCTTTCTCTTTTTCTTCCTCCTTTGGGATCATTGTGTATGAAAAGAAAAACTTTAAATGACAAACC
CAGACTCCAGGTGCCTTGCAAAGGTTGAAGGCCAGCCAGGATTGCTGCTGCTGCTGCTACTCCTGCCAACACCCCTTTCATTGGCATGAC
GGAATGAAAGGATGCATGTCTCCACTTCCTGACCCTCCGCCCACTTCCTTCTCCCTCCACCACCCCCAGTCGTCAGCTCCTTCCCTCATT
TATTTTTGTTAAGTTGTGTGAATTATTTTTAACCCATTTATCCTGTTTGTGCATAGGGTTTTTAAGAAGAAACAGCACAGTGCAACGAGC
AAATCTTTTTGGGGTGTGTGGGAAGCAAGGGAGGGAGGACATGGAGAAAAGTTCTTTAAACAAATAGCAAACTATTGAACATGTGTAAAA

>4378_4378_3_ANK3-MCU_ANK3_chr10_62374944_ENST00000373827_MCU_chr10_74594117_ENST00000536019_length(amino acids)=382AA_BP=81
MGGRRGAALGVPEPRPNFFPRSPTFGGPRSGTGRRDWSSWKEQQQQPHNMASSASSSPAGTEDSAPAQGGFGSDYSRSSRKVHQRIASWQ
NLGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDRGIDRVAIYSPDGVRVAASTGIDLLLLDDF
KLVINDLTYHVRPPKRDLLSHENAATLNDVKTLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGG
LAYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYLLFFHKGAKKSRFDLEKYNQLKDAIAQAEM

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Fusion Gene PPI Analysis for ANK3-MCU


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANK3-MCU


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANK3-MCU


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANK3C0005586Bipolar Disorder8CTD_human;PSYGENET
HgeneANK3C0005587Depression, Bipolar3CTD_human
HgeneANK3C0024713Manic Disorder3CTD_human
HgeneANK3C0036341Schizophrenia3PSYGENET
HgeneANK3C0338831Manic3CTD_human
HgeneANK3C0033975Psychotic Disorders2PSYGENET
HgeneANK3C0525045Mood Disorders2PSYGENET
HgeneANK3C0015923Fetal Alcohol Syndrome1CTD_human
HgeneANK3C0024121Lung Neoplasms1CTD_human
HgeneANK3C0033300Progeria1CTD_human
HgeneANK3C0038220Status Epilepticus1CTD_human
HgeneANK3C0178417Anhedonia1PSYGENET
HgeneANK3C0242379Malignant neoplasm of lung1CTD_human
HgeneANK3C0270823Petit mal status1CTD_human
HgeneANK3C0311335Grand Mal Status Epilepticus1CTD_human
HgeneANK3C0349204Nonorganic psychosis1PSYGENET
HgeneANK3C0393734Complex Partial Status Epilepticus1CTD_human
HgeneANK3C0751522Status Epilepticus, Subclinical1CTD_human
HgeneANK3C0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneANK3C0751524Simple Partial Status Epilepticus1CTD_human
HgeneANK3C0814154Alcohol Related Neurodevelopmental Disorder1CTD_human
HgeneANK3C2985290Fetal Alcohol Spectrum Disorders1CTD_human
HgeneANK3C3146244Alcohol Related Birth Defect1CTD_human
HgeneANK3C3661483Partial Fetal Alcohol Syndrome1CTD_human
HgeneANK3C3809672MENTAL RETARDATION, AUTOSOMAL RECESSIVE 371CTD_human;GENOMICS_ENGLAND;ORPHANET