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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IFT81-INSR (FusionGDB2 ID:HG28981TG3643)

Fusion Gene Summary for IFT81-INSR

check button Fusion gene summary
Fusion gene informationFusion gene name: IFT81-INSR
Fusion gene ID: hg28981tg3643
HgeneTgene
Gene symbol

IFT81

INSR

Gene ID

28981

3643

Gene nameintraflagellar transport 81insulin receptor
SynonymsCDV-1|CDV-1R|CDV1|CDV1R|DV1|SRTD19CD220|HHF5
Cytomap('IFT81')('INSR')

12q24.11

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionintraflagellar transport protein 81 homologcarnitine deficiency-associated gene expressed in ventricle 1carnitine deficiency-associated protein expressed in ventricle 1insulin receptorIR
Modification date2020031320200313
UniProtAcc.

P06213

Ensembl transtripts involved in fusion geneENST00000549009, ENST00000242591, 
ENST00000361948, ENST00000552912, 
Fusion gene scores* DoF score6 X 6 X 5=18020 X 13 X 8=2080
# samples 620
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/2080*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IFT81 [Title/Abstract] AND INSR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIFT81(110574665)-INSR(7184648), # samples:2
Anticipated loss of major functional domain due to fusion event.IFT81-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT81-INSR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT81-INSR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IFT81-INSR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneINSR

GO:0001934

positive regulation of protein phosphorylation

7556070

TgeneINSR

GO:0002092

positive regulation of receptor internalization

25401701

TgeneINSR

GO:0007186

G protein-coupled receptor signaling pathway

9092559

TgeneINSR

GO:0008284

positive regulation of cell proliferation

17925406

TgeneINSR

GO:0008286

insulin receptor signaling pathway

6849137|8440175|20455999

TgeneINSR

GO:0018108

peptidyl-tyrosine phosphorylation

8496180

TgeneINSR

GO:0032148

activation of protein kinase B activity

7556070

TgeneINSR

GO:0032869

cellular response to insulin stimulus

8440175

TgeneINSR

GO:0043410

positive regulation of MAPK cascade

20455999

TgeneINSR

GO:0045725

positive regulation of glycogen biosynthetic process

17925406

TgeneINSR

GO:0046326

positive regulation of glucose import

3518947

TgeneINSR

GO:0046777

protein autophosphorylation

6849137|8496180

TgeneINSR

GO:0060267

positive regulation of respiratory burst

9092559


check buttonFusion gene breakpoints across IFT81 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across INSR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HS-01AIFT81chr12

110574665

-INSRchr19

7184648

-
ChimerDB4SARCTCGA-3B-A9HS-01AIFT81chr12

110574665

+INSRchr19

7184648

-


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Fusion Gene ORF analysis for IFT81-INSR

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000549009ENST00000302850IFT81chr12

110574665

+INSRchr19

7184648

-
3UTR-3CDSENST00000549009ENST00000341500IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000242591ENST00000302850IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000242591ENST00000341500IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000361948ENST00000302850IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000361948ENST00000341500IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000552912ENST00000302850IFT81chr12

110574665

+INSRchr19

7184648

-
In-frameENST00000552912ENST00000341500IFT81chr12

110574665

+INSRchr19

7184648

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000552912IFT81chr12110574665+ENST00000341500INSRchr197184648-917391113043711413
ENST00000552912IFT81chr12110574665+ENST00000302850INSRchr197184648-483791113044071425
ENST00000242591IFT81chr12110574665+ENST00000341500INSRchr197184648-9549128750647471413
ENST00000242591IFT81chr12110574665+ENST00000302850INSRchr197184648-5213128750647831425
ENST00000361948IFT81chr12110574665+ENST00000341500INSRchr197184648-9591132954847891413
ENST00000361948IFT81chr12110574665+ENST00000302850INSRchr197184648-5255132954848251425

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000552912ENST00000341500IFT81chr12110574665+INSRchr197184648-0.000187660.9998123
ENST00000552912ENST00000302850IFT81chr12110574665+INSRchr197184648-0.0014944860.9985056
ENST00000242591ENST00000341500IFT81chr12110574665+INSRchr197184648-0.0002754550.99972457
ENST00000242591ENST00000302850IFT81chr12110574665+INSRchr197184648-0.0019473990.9980526
ENST00000361948ENST00000341500IFT81chr12110574665+INSRchr197184648-0.0002969290.999703
ENST00000361948ENST00000302850IFT81chr12110574665+INSRchr197184648-0.0021138610.9978861

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Fusion Genomic Features for IFT81-INSR


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for IFT81-INSR


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:110574665/chr19:7184648)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.INSR

P06213

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Binding of the SH2 domains of PI3K to phosphotyrosines on IRS1 leads to the activation of PI3K and the generation of phosphatidylinositol-(3, 4, 5)-triphosphate (PIP3), a lipid second messenger, which activates several PIP3-dependent serine/threonine kinases, such as PDPK1 and subsequently AKT/PKB. The net effect of this pathway is to produce a translocation of the glucose transporter SLC2A4/GLUT4 from cytoplasmic vesicles to the cell membrane to facilitate glucose transport. Moreover, upon insulin stimulation, activated AKT/PKB is responsible for: anti-apoptotic effect of insulin by inducing phosphorylation of BAD; regulates the expression of gluconeogenic and lipogenic enzymes by controlling the activity of the winged helix or forkhead (FOX) class of transcription factors. Another pathway regulated by PI3K-AKT/PKB activation is mTORC1 signaling pathway which regulates cell growth and metabolism and integrates signals from insulin. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. Phosphorylated IRS1 recruits GRB2/SOS complex, which triggers the activation of the Ras/RAF/MAP2K/MAPK pathway. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. In adipocytes, inhibits lipolysis (By similarity). {ECO:0000250|UniProtKB:P15208, ECO:0000269|PubMed:12138094, ECO:0000269|PubMed:16314505, ECO:0000269|PubMed:16831875, ECO:0000269|PubMed:8257688, ECO:0000269|PubMed:8276809, ECO:0000269|PubMed:8452530, ECO:0000269|PubMed:9428692}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT81chr12:110574665chr19:7184648ENST00000242591+819132_258260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000361948+812132_258260432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000552912+819132_258260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000242591+8192_121260677.0RegionNote=CH (calponin-homology)-like region
HgeneIFT81chr12:110574665chr19:7184648ENST00000361948+8122_121260432.0RegionNote=CH (calponin-homology)-like region
HgeneIFT81chr12:110574665chr19:7184648ENST00000552912+8192_121260677.0RegionNote=CH (calponin-homology)-like region
TgeneINSRchr12:110574665chr19:7184648ENST000003028501221023_12982171383.0DomainProtein kinase
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122624_7262171383.0DomainFibronectin type-III 1
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122757_8422171383.0DomainFibronectin type-III 2
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122853_9472171383.0DomainFibronectin type-III 3
TgeneINSRchr12:110574665chr19:7184648ENST000003415001211023_12982171371.0DomainProtein kinase
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121624_7262171371.0DomainFibronectin type-III 1
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121757_8422171371.0DomainFibronectin type-III 2
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121853_9472171371.0DomainFibronectin type-III 3
TgeneINSRchr12:110574665chr19:7184648ENST000003028501221104_11102171383.0Nucleotide bindingATP
TgeneINSRchr12:110574665chr19:7184648ENST000003028501221163_11642171383.0Nucleotide bindingATP
TgeneINSRchr12:110574665chr19:7184648ENST000003415001211104_11102171371.0Nucleotide bindingATP
TgeneINSRchr12:110574665chr19:7184648ENST000003415001211163_11642171371.0Nucleotide bindingATP
TgeneINSRchr12:110574665chr19:7184648ENST000003028501221361_13642171383.0RegionNote=PIK3R1-binding
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122733_7412171383.0RegionNote=Insulin-binding
TgeneINSRchr12:110574665chr19:7184648ENST000003415001211361_13642171371.0RegionNote=PIK3R1-binding
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121733_7412171371.0RegionNote=Insulin-binding
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122763_9562171383.0Topological domainExtracellular
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122980_13822171383.0Topological domainCytoplasmic
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121763_9562171371.0Topological domainExtracellular
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121980_13822171371.0Topological domainCytoplasmic
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122957_9792171383.0TransmembraneHelical
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121957_9792171371.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIFT81chr12:110574665chr19:7184648ENST00000242591+819306_389260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000242591+819416_456260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000242591+819490_622260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000361948+812306_389260432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000361948+812416_456260432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000361948+812490_622260432.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000552912+819306_389260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000552912+819416_456260677.0Coiled coilOntology_term=ECO:0000255
HgeneIFT81chr12:110574665chr19:7184648ENST00000552912+819490_622260677.0Coiled coilOntology_term=ECO:0000255
TgeneINSRchr12:110574665chr19:7184648ENST00000302850122182_3392171383.0Compositional biasNote=Cys-rich
TgeneINSRchr12:110574665chr19:7184648ENST0000030285012228_1742171383.0Compositional biasNote=Leu-rich
TgeneINSRchr12:110574665chr19:7184648ENST00000341500121182_3392171371.0Compositional biasNote=Cys-rich
TgeneINSRchr12:110574665chr19:7184648ENST0000034150012128_1742171371.0Compositional biasNote=Leu-rich
TgeneINSRchr12:110574665chr19:7184648ENST0000030285012228_7582171383.0Topological domainExtracellular
TgeneINSRchr12:110574665chr19:7184648ENST0000034150012128_7582171371.0Topological domainExtracellular


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Fusion Gene Sequence for IFT81-INSR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38451_38451_1_IFT81-INSR_IFT81_chr12_110574665_ENST00000242591_INSR_chr19_7184648_ENST00000302850_length(transcript)=5213nt_BP=1287nt
TGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGTTTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCG
GAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCGGTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGT
TAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGATCCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGG
GCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTGTCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAG
GAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGGTTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTT
TTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTC
TCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTC
TGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTC
TTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGC
TCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTC
TTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCA
AGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATT
TGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATC
TTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCC
AAGCTGCAGCAGATGCAAAGCCTGAAATTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGT
GCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCC
CGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGC
AGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCA
CCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAG
GATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTG
AAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGA
CCTTGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCA
CTCAGGGGAAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCC
AGGAGAGAAACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTT
TTGACAAGATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTT
ATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACG
ACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCT
TTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAA
TCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCT
GGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCAT
TCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGA
TCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAG
GCACTGGTGCCGAGGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAG
CTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCA
TCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCT
ACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACT
TGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCT
GCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCT
CCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCA
TCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGG
GACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGT
CTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTG
AGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGA
AGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACG
GAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGA
TGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCC
ATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCC
CTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAA
TCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCG
ACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACC
TGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGA
TGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGC
TGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGT
CCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTC
AGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACC
AATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTC
AAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTT

>38451_38451_1_IFT81-INSR_IFT81_chr12_110574665_ENST00000242591_INSR_chr19_7184648_ENST00000302850_length(amino acids)=1425AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDV
GNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPV
THEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDY
LDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMV
YEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPG
RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS
DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSE

--------------------------------------------------------------
>38451_38451_2_IFT81-INSR_IFT81_chr12_110574665_ENST00000242591_INSR_chr19_7184648_ENST00000341500_length(transcript)=9549nt_BP=1287nt
TGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGTTTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCG
GAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCGGTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGT
TAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGATCCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGG
GCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTGTCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAG
GAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGGTTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTT
TTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTC
TCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTC
TGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTC
TTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGC
TCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTC
TTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCA
AGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATT
TGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATC
TTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCC
AAGCTGCAGCAGATGCAAAGCCTGAAATTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGT
GCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCC
CGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGC
AGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCA
CCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAG
GATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTG
AAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGA
CCTTGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCA
CTCAGGGGAAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCC
AGGAGAGAAACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTT
TTGACAAGATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTT
ATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACG
ACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCT
TTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAA
TCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCT
GGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCAT
TCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGA
TCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAAC
GCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGA
GTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCG
AGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTG
ATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGA
TCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCT
GCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCT
ATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTG
TGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCA
GTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGC
AGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACG
AGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGG
GAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAG
AGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGA
ACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGA
CCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATG
GGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGT
CTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCA
TGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGG
TGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACC
GTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTT
ACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGC
GGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTC
AGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAAC
CTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCC
GCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAG
ACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACA
GGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCA
AATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCAT
TAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTC
ATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACC
CTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAA
AAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCA
TATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGC
CTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATG
TTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCT
GCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTG
TGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAA
CCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGAC
GGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCT
TACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTG
AATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCAT
CGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGG
GATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTA
TTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTT
TTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAA
ATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTA
TTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGG
GGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATT
CTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGA
TGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAA
ATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGG
TGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCT
GAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATG
CAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTT
TTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTT
GATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTT
TCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCA
CAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAA
AGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTG
CTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAAT
ACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTC
ATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAG
GGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCA
CCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACT
TGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGT
CCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTT
TATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGG
GAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATA
TTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGT
CCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGT
CCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTG
AAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCA
GAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAG
AAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATATGGGATAATGACCTGTTTATATTAAAATTCTGATTAAATTAT

>38451_38451_2_IFT81-INSR_IFT81_chr12_110574665_ENST00000242591_INSR_chr19_7184648_ENST00000341500_length(amino acids)=1413AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAA
FPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHL
MWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIII
GPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGE
AETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM
AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI
TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEM

--------------------------------------------------------------
>38451_38451_3_IFT81-INSR_IFT81_chr12_110574665_ENST00000361948_INSR_chr19_7184648_ENST00000302850_length(transcript)=5255nt_BP=1329nt
GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT
TTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCGGAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCG
GTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGTTAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGAT
CCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGGGCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTG
TCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAGGAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGG
TTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTTTTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAG
ACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATT
CCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGC
CAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTC
AGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATT
TAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAA
TGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAA
TGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAA
TAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGC
AAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGCAAAGCCTGAAATTTGCCCGACCATCTGTAAGT
CACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCT
GCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCT
TCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGT
GTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCG
AGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCA
ACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGT
CACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACC
TAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAG
AAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCT
GTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCC
GAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACA
GTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGC
CCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATG
TCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCAC
CCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCC
TCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATT
CGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATT
ACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGACCCTAGGCCATCTCGGAAACGCAGGTCCCTTG
GCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGC
ACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTT
GCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTG
GCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATG
AAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTG
GGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGA
CAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTA
TTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATG
TGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCG
GCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTC
TCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCA
AGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATA
ATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGT
TTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCT
ATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCA
CTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGG
TGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAAT
TCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCC
ACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACT
GTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGA
ACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTC
CCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCC
TATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAG
GGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGA
TGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCT

>38451_38451_3_IFT81-INSR_IFT81_chr12_110574665_ENST00000361948_INSR_chr19_7184648_ENST00000302850_length(amino acids)=1425AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDV
GNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPV
THEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDY
LDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMV
YEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPG
RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS
DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSE

--------------------------------------------------------------
>38451_38451_4_IFT81-INSR_IFT81_chr12_110574665_ENST00000361948_INSR_chr19_7184648_ENST00000341500_length(transcript)=9591nt_BP=1329nt
GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT
TTCGTGAGGAGAATTTGAGGTAACCTCGCCAACTCGCGGTCGGAAGCTCCTCTGAACCCCGAAATAGGAGAGAGCTCCCGTCCTCTCTCG
GTCCTGATGCAGCACCTCGCAAGTGGAAGGGGTCGTCGCGGTTAAGCCCCCGGATAGGGGAATCGGGCCCCTTCTGGGATTCGAGCGGAT
CCAGGCCGCTCCCTGGAGGGATGAACTGTCGAGGGGCCCAGGGCAGCCCCCGCTAGAGGCCCGGTCGGGTGTGGGGTCCCCTGTCCCCTG
TCCCGAGCCCGGGGAGGGGGACACTATTTCTGGTACTCCCAGGAGGCTGCGGGTCGATGCTCGTGCCAGCCTGGGACCCAGGCAGCACGG
TTTCTCTCCCAAATTGTGCCAGAGAACACGCACGTCCTGGTTTTCATTGTTCCCCGCCTCCTGCGACTCGTTTGTGGTTAAAATTATAAG
ACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTTTAGGAAGAACTATAATTTAATCACGTTTGATT
CCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCCAAAGCAACTTGTGGATATCAGAGAGGAGATGC
CAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTCAGGAAATGCCACAGATATGAGTACTTTTCGTC
AGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCAGAGGACTAATGAACTGAAGAAAAGAGCATATT
TAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGTGGCTGACACCAATAAACAGTATGAAGAGTTAA
TGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTCTACAGCAGAAATAAGAAAGGATATCAGTGCAA
TGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGAGACAGCTCAGAATCATCAATGGATGCTTAAAA
TAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACAGGAACAAAAGAATCAGCTATTTCATGCAGTGC
AAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGCAAAGCCTGAAATTTGCCCGACCATCTGTAAGT
CACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTCTCAGCCCGACGACCCCACCAAGTGCGTGGCCT
GCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCACTTCCAGGACTGGCGCTGTGTGAACTTCAGCT
TCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTACGTCATTCACAACAACAAGTGCATCCCTGAGT
GTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCCCTGTCCCAAGGTGTGCCACCTCCTAGAAGGCG
AGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAACGGGAGTCTGATCATCAACATTCGAGGAGGCA
ACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTATCTAAAAATCCGCCGATCCTACGCTCTGGTGT
CACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAACTACTCCTTCTATGCCTTGGACAACCAGAACC
TAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTTCTTCCACTATAACCCCAAACTCTGCTTGTCAG
AAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACATTGCCCTGAAGACCAATGGGGACCAGGCATCCT
GTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCTGAGATGGGAGCCGTACTGGCCCCCCGACTTCC
GAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGAGTTCGACGGGCAGGATGCGTGTGGTTCCAACA
GTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAACCACCCAGGGTGGCTGATGCGGGGTCTCAAGC
CCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCGGACCTATGGGGCCAAGAGTGACATCATTTATG
TCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTCATCATCCCAGATTATTCTGAAGTGGAAACCAC
CCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGAAGACAGTGAGCTGTTCGAGCTGGATTATTGCC
TCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTCTCAGAAGCACAACCAGAGTGAGTATGAGGATT
CGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGAGGAGTCCTCGTTTAGGAAGACGTTTGAGGATT
ACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGG
TGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGC
TGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGG
CAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCG
TCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGC
ATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGG
CCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAA
TTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGC
CGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGG
AGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCA
AGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGG
TCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGG
CTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGA
TTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGG
TCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTC
TGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTT
GGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATC
AACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTG
TCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGC
TGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGT
CCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGC
CTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGA
AAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTG
GTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGAC
GGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTT
TTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTTGTGGAACAAAAGTTCGAAAGAAAAAACAAAAC
AAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGATGGTTTTTTTGGTTTTTTTTTTTTCTCTCATCC
AGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTGCTGCTTTCATATTTTGGATAAGGGTCTGTGGT
CCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGTGTGTGCAAAGTATCCATGCGGAGTTGATGCTT
TGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTTCCTTCTTATTGACTGGGAGACTGTGCTCTCGA
CAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGTGGCCAAGGGAGGAGCATTTCATTTGGAGTGAT
TATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGAAAGAAAAAACAAAATGGAAAAAGGAAAAAAAA
AAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAGTCTCTGGTATTAGCCTCATAAGTTATTGACTA
TTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGGAAGGGGAGGGAGTCAGGCACAAGTGGCCTCTT
TGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTTTTGGATGTTGTGAGGCCACGTGGAGTGTGTGA
GAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGTTCGGATAAGCTGGTAGCTACCTAGCTCTGAGC
CTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCGTTTCCTCTCCCGGGTGTGAACATCCTAACCGT
TATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGGGAACATCTAAGCAATGTAAGAGAGAGGTGCAC
TGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAACTCCCGGAAGCTGCTCTGAGCCCGGTGACCTC
ATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCCCTAAGAGAGTAGAGTCTGGAGGAGAAACCGTG
AAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTCTCTTTGCAAAAAGAACCACCACAGCTGCTCAA
AGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTCCTGAGTGCATTTTCTTACAACTTTTTGACTGC
TTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGGCAACCTCCAAGCCCTCTCAATTCTTGATTAAG
AACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGAAAATACAGCATGTAAAAATATTGCTGAGGAGC
CTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTTGTAAATATGAGGGTCTGTACCTAAATTTAAAA
AAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTATACTACACTAGCTGCAATTTTCACATTTTTCT
AATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAATCACTCTGAAAATCACTCTCATAAAAAATGGAG
CGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCTTTTTTCAGCACAGTCTACCTCAGTGTATTGTT
AAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTCTGAATCAGGGAACGTGTGTATCAGCTGATTCG
AATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCCTTTATGCGAGCATAGATCCTTTTCTTCCTGGC
TGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGTCACTATGTTCCCCAAACATAAACTAAGTTCCA
GGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGTGAGAGATGGCTGCCGGGGCAAAGACGGGCTTT
GATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGGTGCCCTGGGCTCCCTGATGGTTTATGCCCACT
CCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAATTCTCCAAGTGGGATGGGAGCATGTGAGGGAAA
TTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTTGCAACAACACCTTGGACCTCTGTGTTGGGGTT
TGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGAGTCTAGGCAGGACCAGTGGGGCCCAAATCTTG
CTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGGAGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTG
CAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAACAGCTATTGGGTTGCAAACCTCCTTTGACATT
AGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTGGGAGTTTGTAGTGTTAAGTTGCAACAACAACA
ACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATGTCTCACTATGATTAAAACCCTTTTCATTAATG
TAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTTTCTCTCTGCATCAGTGATGTCAAATACGCATC
AGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTGAGAAAGAGAAGCACTGCTGCTTGTCTGGATAT
AGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCATCCTGTGACCCTGGGGACTATGTTACCAACTGA
CAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTATTGGATTGGGAGGTGTTTATTTGTAGTCTGCT
GTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGGTAAATGGATGTGCTGTAGTCCCAGTGCTAATC
ATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCTGGTGAGTCCTTGACACCTTAGGCTCTTCAGAA
ACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACACAGAGAGGGGTGTCACTTCAGAAAATCTTCCAG
CATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGGTCAGCACTTTTTTTTTTCCTAGAACATACAAA
AGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCCCGAGAAATGGGAGTGAGGGGAGGGGACACAAT
GGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCAGCCAAATTTCTATCTGGGTGCGGGCCACTGAA
AATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAAGGAAGAGCCTCAAAATAAGTGTGCACCCATGC
ACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTCGTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCT
GTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAACACAAAACCCCCCAACAGCTCAATTATTATTT
TTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTTTGGAATATTGAAATCGTTCTGCATGTAAAATA

>38451_38451_4_IFT81-INSR_IFT81_chr12_110574665_ENST00000361948_INSR_chr19_7184648_ENST00000341500_length(amino acids)=1413AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAA
FPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHL
MWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIII
GPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGE
AETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM
AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI
TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEM

--------------------------------------------------------------
>38451_38451_5_IFT81-INSR_IFT81_chr12_110574665_ENST00000552912_INSR_chr19_7184648_ENST00000302850_length(transcript)=4837nt_BP=911nt
GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT
TTCGTGAGGAGAATTTGAGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTT
TAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCC
AAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTC
AGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCA
GAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGT
GGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTC
TACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGA
GACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACA
GGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGC
AAAGCCTGAAATTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTC
TCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCA
CTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTA
CGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCC
CTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAA
CGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTA
TCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAA
CTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTT
CTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACAT
TGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCT
GAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGA
GTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAA
CCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCG
GACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTC
ATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGA
AGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTC
TCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGA
GGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGAAAAACCTCTTCAGGCACTGGTGCCGAGGA
CCCTAGGCCATCTCGGAAACGCAGGTCCCTTGGCGATGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTC
CTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAGGCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACA
CTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAACCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGAC
CATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCCTGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCC
GAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGTGAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCA
CTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCTGTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGG
CTCTTGGACGGAACCCACCTATTTCTACGTGACAGACTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTT
TGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTATCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTC
TTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTTTCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCAC
CCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCATGGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGT
GGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCGAGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCA
TCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGGCCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTA
CCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCCTGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGC
TGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGTGCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAA
AATTGGAGACTTTGGAATGACCAGAGACATCTATGAAACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGC
ACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTCTTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGA
ACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTTGAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAG
AGTCACTGACCTCATGCGCATGTGCTGGCAATTCAACCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCT
GCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAGCGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACAT
GGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCAGAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAG
CTACGAGGAACACATCCCTTACACACACATGAACGGAGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACA
GTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCATTTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTC
TACCATGTCCAATGGAGTTCAGAGATCGTTCCTATACATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTG
CAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGTTTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTG
TTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGAAAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTG

>38451_38451_5_IFT81-INSR_IFT81_chr12_110574665_ENST00000552912_INSR_chr19_7184648_ENST00000302850_length(amino acids)=1425AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDV
GNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPV
THEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDY
LDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMV
YEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPG
RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSS
DMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSE

--------------------------------------------------------------
>38451_38451_6_IFT81-INSR_IFT81_chr12_110574665_ENST00000552912_INSR_chr19_7184648_ENST00000341500_length(transcript)=9173nt_BP=911nt
GTAACTCTACGGCCTAGCAACCGTTGCCAAGGAGCTCGACTCTGGGAGCGGTCTAGAGCCCGGGCGCCTCCTGGGGGGTGGGGAAACGGT
TTCGTGAGGAGAATTTGAGTTAAAATTATAAGACCTAATTATGAGTGATCAAATTAAATTCATTATGGACAGTCTCAATAAGGAGCCCTT
TAGGAAGAACTATAATTTAATCACGTTTGATTCCTTGGAGCCAATGCAACTATTACAAGTTCTCAGTGATGTTCTGGCTGAGATTGACCC
AAAGCAACTTGTGGATATCAGAGAGGAGATGCCAGAGCAGACAGCCAAACGAATGTTGAGCCTTCTTGGTATTCTTAAGTACAAACCTTC
AGGAAATGCCACAGATATGAGTACTTTTCGTCAGGGTTTGGTGATTGGAAGTAAACCTGTAATTTACCCAGTGCTCCACTGGCTTCTTCA
GAGGACTAATGAACTGAAGAAAAGAGCATATTTAGCTCGTTTTTTAATAAAACTTGAGGTACCAAGTGAGTTTCTTCAGGATGAAACTGT
GGCTGACACCAATAAACAGTATGAAGAGTTAATGGAAGCCTTTAAAACTTTGCATAAAGAATATGAGCAGCTCAAGATATCTGGATTTTC
TACAGCAGAAATAAGAAAGGATATCAGTGCAATGGAAGAAGAAAAGGATCAGCTCATTAAGAGAGTTGAACATTTGAAGAAAAGGGTTGA
GACAGCTCAGAATCATCAATGGATGCTTAAAATAGCAAGGCAACTTCGAGTTGAAAAAGAGAGAGAAGAATATCTTGCACAACAGAAACA
GGAACAAAAGAATCAGCTATTTCATGCAGTGCAAAGATTGCAAAGAGTACAAAACCAGCTGAAAAGCATGCGCCAAGCTGCAGCAGATGC
AAAGCCTGAAATTTGCCCGACCATCTGTAAGTCACACGGCTGCACCGCCGAAGGCCTCTGTTGCCACAGCGAGTGCCTGGGCAACTGTTC
TCAGCCCGACGACCCCACCAAGTGCGTGGCCTGCCGCAACTTCTACCTGGACGGCAGGTGTGTGGAGACCTGCCCGCCCCCGTACTACCA
CTTCCAGGACTGGCGCTGTGTGAACTTCAGCTTCTGCCAGGACCTGCACCACAAATGCAAGAACTCGCGGAGGCAGGGCTGCCACCAGTA
CGTCATTCACAACAACAAGTGCATCCCTGAGTGTCCCTCCGGGTACACGATGAATTCCAGCAACTTGCTGTGCACCCCATGCCTGGGTCC
CTGTCCCAAGGTGTGCCACCTCCTAGAAGGCGAGAAGACCATCGACTCGGTGACGTCTGCCCAGGAGCTCCGAGGATGCACCGTCATCAA
CGGGAGTCTGATCATCAACATTCGAGGAGGCAACAATCTGGCAGCTGAGCTAGAAGCCAACCTCGGCCTCATTGAAGAAATTTCAGGGTA
TCTAAAAATCCGCCGATCCTACGCTCTGGTGTCACTTTCCTTCTTCCGGAAGTTACGTCTGATTCGAGGAGAGACCTTGGAAATTGGGAA
CTACTCCTTCTATGCCTTGGACAACCAGAACCTAAGGCAGCTCTGGGACTGGAGCAAACACAACCTCACCATCACTCAGGGGAAACTCTT
CTTCCACTATAACCCCAAACTCTGCTTGTCAGAAATCCACAAGATGGAAGAAGTTTCAGGAACCAAGGGGCGCCAGGAGAGAAACGACAT
TGCCCTGAAGACCAATGGGGACCAGGCATCCTGTGAAAATGAGTTACTTAAATTTTCTTACATTCGGACATCTTTTGACAAGATCTTGCT
GAGATGGGAGCCGTACTGGCCCCCCGACTTCCGAGACCTCTTGGGGTTCATGCTGTTCTACAAAGAGGCCCCTTATCAGAATGTGACGGA
GTTCGACGGGCAGGATGCGTGTGGTTCCAACAGTTGGACGGTGGTAGACATTGACCCACCCCTGAGGTCCAACGACCCCAAATCACAGAA
CCACCCAGGGTGGCTGATGCGGGGTCTCAAGCCCTGGACCCAGTATGCCATCTTTGTGAAGACCCTGGTCACCTTTTCGGATGAACGCCG
GACCTATGGGGCCAAGAGTGACATCATTTATGTCCAGACAGATGCCACCAACCCCTCTGTGCCCCTGGATCCAATCTCAGTGTCTAACTC
ATCATCCCAGATTATTCTGAAGTGGAAACCACCCTCCGACCCCAATGGCAACATCACCCACTACCTGGTTTTCTGGGAGAGGCAGGCGGA
AGACAGTGAGCTGTTCGAGCTGGATTATTGCCTCAAAGGGCTGAAGCTGCCCTCGAGGACCTGGTCTCCACCATTCGAGTCTGAAGATTC
TCAGAAGCACAACCAGAGTGAGTATGAGGATTCGGCCGGCGAATGCTGCTCCTGTCCAAAGACAGACTCTCAGATCCTGAAGGAGCTGGA
GGAGTCCTCGTTTAGGAAGACGTTTGAGGATTACCTGCACAACGTGGTTTTCGTCCCCAGGCCATCTCGGAAACGCAGGTCCCTTGGCGA
TGTTGGGAATGTGACGGTGGCCGTGCCCACGGTGGCAGCTTTCCCCAACACTTCCTCGACCAGCGTGCCCACGAGTCCGGAGGAGCACAG
GCCTTTTGAGAAGGTGGTGAACAAGGAGTCGCTGGTCATCTCCGGCTTGCGACACTTCACGGGCTATCGCATCGAGCTGCAGGCTTGCAA
CCAGGACACCCCTGAGGAACGGTGCAGTGTGGCAGCCTACGTCAGTGCGAGGACCATGCCTGAAGCCAAGGCTGATGACATTGTTGGCCC
TGTGACGCATGAAATCTTTGAGAACAACGTCGTCCACTTGATGTGGCAGGAGCCGAAGGAGCCCAATGGTCTGATCGTGCTGTATGAAGT
GAGTTATCGGCGATATGGTGATGAGGAGCTGCATCTCTGCGTCTCCCGCAAGCACTTCGCTCTGGAACGGGGCTGCAGGCTGCGTGGGCT
GTCACCGGGGAACTACAGCGTGCGAATCCGGGCCACCTCCCTTGCGGGCAACGGCTCTTGGACGGAACCCACCTATTTCTACGTGACAGA
CTATTTAGACGTCCCGTCAAATATTGCAAAAATTATCATCGGCCCCCTCATCTTTGTCTTTCTCTTCAGTGTTGTGATTGGAAGTATTTA
TCTATTCCTGAGAAAGAGGCAGCCAGATGGGCCGCTGGGACCGCTTTACGCTTCTTCAAACCCTGAGTATCTCAGTGCCAGTGATGTGTT
TCCATGCTCTGTGTACGTGCCGGACGAGTGGGAGGTGTCTCGAGAGAAGATCACCCTCCTTCGAGAGCTGGGGCAGGGCTCCTTCGGCAT
GGTGTATGAGGGCAATGCCAGGGACATCATCAAGGGTGAGGCAGAGACCCGCGTGGCGGTGAAGACGGTCAACGAGTCAGCCAGTCTCCG
AGAGCGGATTGAGTTCCTCAATGAGGCCTCGGTCATGAAGGGCTTCACCTGCCATCACGTGGTGCGCCTCCTGGGAGTGGTGTCCAAGGG
CCAGCCCACGCTGGTGGTGATGGAGCTGATGGCTCACGGAGACCTGAAGAGCTACCTCCGTTCTCTGCGGCCAGAGGCTGAGAATAATCC
TGGCCGCCCTCCCCCTACCCTTCAAGAGATGATTCAGATGGCGGCAGAGATTGCTGACGGGATGGCCTACCTGAACGCCAAGAAGTTTGT
GCATCGGGACCTGGCAGCGAGAAACTGCATGGTCGCCCATGATTTTACTGTCAAAATTGGAGACTTTGGAATGACCAGAGACATCTATGA
AACGGATTACTACCGGAAAGGGGGCAAGGGTCTGCTCCCTGTACGGTGGATGGCACCGGAGTCCCTGAAGGATGGGGTCTTCACCACTTC
TTCTGACATGTGGTCCTTTGGCGTGGTCCTTTGGGAAATCACCAGCTTGGCAGAACAGCCTTACCAAGGCCTGTCTAATGAACAGGTGTT
GAAATTTGTCATGGATGGAGGGTATCTGGATCAACCCGACAACTGTCCAGAGAGAGTCACTGACCTCATGCGCATGTGCTGGCAATTCAA
CCCCAAGATGAGGCCAACCTTCCTGGAGATTGTCAACCTGCTCAAGGACGACCTGCACCCCAGCTTTCCAGAGGTGTCGTTCTTCCACAG
CGAGGAGAACAAGGCTCCCGAGAGTGAGGAGCTGGAGATGGAGTTTGAGGACATGGAGAATGTGCCCCTGGACCGTTCCTCGCACTGTCA
GAGGGAGGAGGCGGGGGGCCGGGATGGAGGGTCCTCGCTGGGTTTCAAGCGGAGCTACGAGGAACACATCCCTTACACACACATGAACGG
AGGCAAGAAAAACGGGCGGATTCTGACCTTGCCTCGGTCCAATCCTTCCTAACAGTGCCTACCGTGGCGGGGGCGGGCAGGGGTTCCCAT
TTTCGCTTTCCTCTGGTTTGAAAGCCTCTGGAAAACTCAGGATTCTCACGACTCTACCATGTCCAATGGAGTTCAGAGATCGTTCCTATA
CATTTCTGTTCATCTTAAGGTGGACTCGTTTGGTTACCAATTTAACTAGTCCTGCAGAGGATTTAACTGTGAACCTGGAGGGCAAGGGGT
TTCCACAGTTGCTGCTCCTTTGGGGCAACGACGGTTTCAAACCAGGATTTTGTGTTTTTTCGTTCCCCCCACCCGCCCCCAGCAGATGGA
AAGAAAGCACCTGTTTTTACAAATTCTTTTTTTTTTTTTTTTTTTTTGCTGGTGTCTGAGCTTCAGTATAAAAGACAAAACTTCCTGTTT
GTGGAACAAAAGTTCGAAAGAAAAAACAAAACAAAAACACCCAGCCCTGTTCCAGGAGAATTTCAAGTTTTACAGGTTGAGCTTCAAGAT
GGTTTTTTTGGTTTTTTTTTTTTCTCTCATCCAGGCTGAAGGATTTTTTTTTTCTTTACAAAATGAGTTCCTCAAATTGACCAATAGCTG
CTGCTTTCATATTTTGGATAAGGGTCTGTGGTCCCGGCGTGTGCTCACGTGTGTATGCACGTGTGTGTGTCCATTAGACACGGCTGATGT
GTGTGCAAAGTATCCATGCGGAGTTGATGCTTTGGGAATTGGCTCATGAAGGTTCTTCTCAAGGGTGCGAGCTCATCCCCCTCTCTCCTT
CCTTCTTATTGACTGGGAGACTGTGCTCTCGACAGATTCTTCTTGTGTCAGAAGTCTAGCCTCAGGTTTCTACCCTCCCTTCACATTGGT
GGCCAAGGGAGGAGCATTTCATTTGGAGTGATTATGAATCTTTTCAAGACCAAACCAAGCTAGGACATTAAAAAAAAAAAAAGAAAAAGA
AAGAAAAAACAAAATGGAAAAAGGAAAAAAAAAAAGAACTGAGATGACAGAGTTTTGAGAATATATTTGTACCATATTTAATTTTTAAAG
TCTCTGGTATTAGCCTCATAAGTTATTGACTATTCCCCGGGGTTGGCGGGGAGTGGGGACATGAGTTGGTCTGCCTGTTGTGGGGCCGGG
AAGGGGAGGGAGTCAGGCACAAGTGGCCTCTTTGTTTGGTCTTAAAGGCATCCATTTCTGGGAATGAAGCCATGTTCGCTGCTAACACTT
TTGGATGTTGTGAGGCCACGTGGAGTGTGTGAGAGACTAGGTTTTATGGATGGTCTGGTTCAGGTACCAGGTCTGCTGGAAGGTTCCTGT
TCGGATAAGCTGGTAGCTACCTAGCTCTGAGCCTGCCTTCAAGAACACCTGTGTTCATCCTCTGATTCTCTGTGTGTACCTCTTGTGGCG
TTTCCTCTCCCGGGTGTGAACATCCTAACCGTTATTGTGCAAACCCAAGAACGTCAGATCCCAAAGCACAACAACCTGGATGGACTTTGG
GAACATCTAAGCAATGTAAGAGAGAGGTGCACTGAGAGTACGTCTTGGTCCCCTCCACCCTGAGAGCATCTGACGGTCCTCAGTACTGAA
CTCCCGGAAGCTGCTCTGAGCCCGGTGACCTCATCTGGGCCAGGTGTGGTGCCTGAGCTGAATGCTCAGGTGCTTACAGTGTTGCAATCC
CTAAGAGAGTAGAGTCTGGAGGAGAAACCGTGAAAAAGACCTTACACACCACCAAGAACTTCCGAATGGGCGTGAATCCACCGTTTCTTC
TCTTTGCAAAAAGAACCACCACAGCTGCTCAAAGAACACAGTGAACTCATCACTTTGGTTCATCAAAAAATCATCGCCCATGCGTTATTC
CTGAGTGCATTTTCTTACAACTTTTTGACTGCTTCCTTTTCTTCTTCTCTTAAGAGTTGTGGGCTTAAGAATGGGATAGAGTCATAATGG
CAACCTCCAAGCCCTCTCAATTCTTGATTAAGAACACAGGTAGACATGAATCCCAATTGTCTATTGCTATCTTATTTATATGATTCGGGA
AAATACAGCATGTAAAAATATTGCTGAGGAGCCTCAGTGATTGGGTACAAGAAGCAAGAGTACAGAAATTATTTTTGCCAAATTTATTTT
GTAAATATGAGGGTCTGTACCTAAATTTAAAAAAAAAACACGTAGAACTAGGTATTTTGTTCTCTTCTTAGTAAATTTGTAGTGGTTGTA
TACTACACTAGCTGCAATTTTCACATTTTTCTAATTCAGAAAGGTTTTTCTTATATTAGGGGAAAAAGTATTTATTTTAATATATAAAAT
CACTCTGAAAATCACTCTCATAAAAAATGGAGCGCATGTAAATTTTTATCAAAGAAAAATAAACAGGTGAATGGGGGATAGTGATTTTCT
TTTTTCAGCACAGTCTACCTCAGTGTATTGTTAAGATGTGATTCAATCATGGACATCTTTGAGATTTCAGAATTCTACCTGGAACCGGTC
TGAATCAGGGAACGTGTGTATCAGCTGATTCGAATGCCAGGGACCAGTAAGAATTTTGAGGGAGGGAGTTGGGATGGAGAAGGTATGGCC
TTTATGCGAGCATAGATCCTTTTCTTCCTGGCTGGTAATATTCTTCTCTGAATTTAATCTTCCTTTAAAAAAAAATCCTCCATCTATTGT
CACTATGTTCCCCAAACATAAACTAAGTTCCAGGCTGTCATGATGTATCTGATATATGGGGTAACCCAGCAAGGTGTACCTTCCTTTGGT
GAGAGATGGCTGCCGGGGCAAAGACGGGCTTTGATTCAGAGCAAGCATTCCCACCTGTTCCATGGAATCCCCCTGAAGTGAGCACAAAGG
TGCCCTGGGCTCCCTGATGGTTTATGCCCACTCCTTTCAGGCTGGTGATGCACCTTACACACAAACACCTAATGCAATGTCTTTTTAAAT
TCTCCAAGTGGGATGGGAGCATGTGAGGGAAATTCCAATCCAAAACCCATTAATGTGCTGAACGCTTTTTTTTTTTTTTTTTTTTTTTTT
GCAACAACACCTTGGACCTCTGTGTTGGGGTTTGACTGACCTCAAGCTGATATTATTGGACCTTGTGCAGCTTTGATAACCCATGTGAGA
GTCTAGGCAGGACCAGTGGGGCCCAAATCTTGCTGCTCTTGTACTTTTAGGCACTGCCCTTGCAGACTCACCTTTCTCCACCTGCCCTGG
AGAAAGGTAGGGTGTGCTGGGCCTGCCCCTTGCAAATGGGATTCACCAGTTTCATTTATTTGACTCTACTGCCACAGTGAAAAGAGCAAA
CAGCTATTGGGTTGCAAACCTCCTTTGACATTAGGAAATGTTGACTTTGTAACAATAAAACTTTGGTCCTAGAAAGACACGGTTGTCCTG
GGAGTTTGTAGTGTTAAGTTGCAACAACAACAACAAAAAGCAACAAAACCAGCTTAGGATAACACTTTTTGTTGCTTGTTCTTAAAGATG
TCTCACTATGATTAAAACCCTTTTCATTAATGTAGTGAAAGCCACACAGGAGTTCCTTCTTCCAGGAGGAGAATACCAAGCACATCACTT
TCTCTCTGCATCAGTGATGTCAAATACGCATCAGAAAATGTTCAGGTTTTAGGAGCTGTCCTAGGTGCTGTTTCATCATTGGAAGCAGTG
AGAAAGAGAAGCACTGCTGCTTGTCTGGATATAGGCTGAGGATGATTGAGAGAAGCTGTGGGAACTGACACAAGGGTCTGCATAGGTCAT
CCTGTGACCCTGGGGACTATGTTACCAACTGACAGACAGATCTTTCACTGTATCCTAGCAGGGCAGGTAGTCCACCAAGAAATGTGCTTA
TTGGATTGGGAGGTGTTTATTTGTAGTCTGCTGTAACACGTGTGAAAGAGCAGGAGCGTCATCAGCATATGACTTGCGCTGGTCATCCGG
TAAATGGATGTGCTGTAGTCCCAGTGCTAATCATTTCTCTCCTTCACAGTGGGTGGAAGTTTAGGGTTAAATGTCCTTTGAATGTCACCT
GGTGAGTCCTTGACACCTTAGGCTCTTCAGAAACAATGGTTTTGTTGAGGATGGGGAACAGGGAATGCCGATTTTATATACATGGTACAC
AGAGAGGGGTGTCACTTCAGAAAATCTTCCAGCATGTTCTTCAGAATATTAATTTATATGCGAGGTGAGGTTGGGAATGAAAAGAACAGG
TCAGCACTTTTTTTTTTCCTAGAACATACAAAAGAACATGGTGGACTTTCAGGGAGTGCAATGGAAGGTGAATATTTCCTTAAGGGTCCC
CGAGAAATGGGAGTGAGGGGAGGGGACACAATGGCTTTTTGAGCTTACTTTTACCTTCTGATACTAGTCAAGGTCCAGAACCAGCCACCA
GCCAAATTTCTATCTGGGTGCGGGCCACTGAAAATCCTTGTTAAAAACCAGATCACAAATCTGGGGCTCTTGGTCCCATTGGAGAAGGAA
GGAAGAGCCTCAAAATAAGTGTGCACCCATGCACATATTCAGGAACAGCTTGTTTAGTCTTTACACTTTGCCTGAAAGTTGCTTCTCCTC
GTCCCTTTGTGTGCCTGGGTGGCCTCGGCCCTGTGCGTTGGCAACGCAGGATCAAATGTGCTGCAGCTTTTGCAGAAAACAACTCAGAAA
CACAAAACCCCCCAACAGCTCAATTATTATTTTTTCAATGTTTTCCTACAAGAGCCAAGTAGCACCATGTACAGAAGACGCCTTTTTTTT

>38451_38451_6_IFT81-INSR_IFT81_chr12_110574665_ENST00000552912_INSR_chr19_7184648_ENST00000341500_length(amino acids)=1413AA_BP=261
MSDQIKFIMDSLNKEPFRKNYNLITFDSLEPMQLLQVLSDVLAEIDPKQLVDIREEMPEQTAKRMLSLLGILKYKPSGNATDMSTFRQGL
VIGSKPVIYPVLHWLLQRTNELKKRAYLARFLIKLEVPSEFLQDETVADTNKQYEELMEAFKTLHKEYEQLKISGFSTAEIRKDISAMEE
EKDQLIKRVEHLKKRVETAQNHQWMLKIARQLRVEKEREEYLAQQKQEQKNQLFHAVQRLQRVQNQLKSMRQAAADAKPEICPTICKSHG
CTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPS
GYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN
ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWT
QYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKG
LKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRPSRKRRSLGDVGNVTVAVPTVAA
FPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHL
MWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIII
GPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGE
AETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQM
AAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEI
TSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENKAPESEELEM

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Fusion Gene PPI Analysis for IFT81-INSR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IFT81-INSR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneINSRP06213DB00046Insulin lisproAgonistBiotechApproved
TgeneINSRP06213DB00047Insulin glargineAgonistBiotechApproved
TgeneINSRP06213DB00071Insulin porkBinderBiotechApproved
TgeneINSRP06213DB01306Insulin aspartAgonistBiotechApproved
TgeneINSRP06213DB01307Insulin detemirAgonistBiotechApproved
TgeneINSRP06213DB01309Insulin glulisineAgonistBiotechApproved
TgeneINSRP06213DB09129Chromic chlorideActivatorSmall moleculeApproved
TgeneINSRP06213DB09564Insulin degludecLigandBiotechApproved
TgeneINSRP06213DB14751Mecasermin rinfabateBiotechApproved
TgeneINSRP06213DB00030Insulin humanAgonistBiotechApproved|Investigational
TgeneINSRP06213DB01277MecaserminBiotechApproved|Investigational
TgeneINSRP06213DB12010FostamatinibInhibitorSmall moleculeApproved|Investigational
TgeneINSRP06213DB12267BrigatinibBindingSmall moleculeApproved|Investigational

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Related Diseases for IFT81-INSR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIFT81C4693524SHORT-RIB THORACIC DYSPLASIA 19 WITH OR WITHOUT POLYDACTYLY3GENOMICS_ENGLAND;UNIPROT
TgeneC0265344Donohue Syndrome23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0342278Diabetes Mellitus, Insulin-Resistant, with Acanthosis Nigricans18CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0271695Rabson-Mendenhall Syndrome10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0011860Diabetes Mellitus, Non-Insulin-Dependent3UNIPROT
TgeneC0002152Alloxan Diabetes2CTD_human
TgeneC0011853Diabetes Mellitus, Experimental2CTD_human
TgeneC0020459Hyperinsulinism2CTD_human
TgeneC0021655Insulin Resistance2CTD_human
TgeneC0024115Lung diseases2CTD_human
TgeneC0038433Streptozotocin Diabetes2CTD_human
TgeneC0342336Insulin resistance - type A2ORPHANET
TgeneC0920563Insulin Sensitivity2CTD_human
TgeneC1257963Endogenous Hyperinsulinism2CTD_human
TgeneC1257964Exogenous Hyperinsulinism2CTD_human
TgeneC1257965Compensatory Hyperinsulinemia2CTD_human
TgeneC1864952Hyperinsulinemic Hypoglycemia, Familial, 52CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0002395Alzheimer's Disease1CTD_human
TgeneC0011265Presenile dementia1CTD_human
TgeneC0011882Diabetic Neuropathies1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0020429Hyperalgesia1CTD_human
TgeneC0020456Hyperglycemia1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0030567Parkinson Disease1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0235833Congenital diaphragmatic hernia1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0265699Congenital hernia of foramen of Morgagni1CTD_human
TgeneC0265700Congenital hernia of foramen of Bochdalek1CTD_human
TgeneC0271650Impaired glucose tolerance1CTD_human
TgeneC0271673Symmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneC0271674Asymmetric Diabetic Proximal Motor Neuropathy1CTD_human
TgeneC0271678Diabetic Mononeuropathy1CTD_human
TgeneC0271680Diabetic Polyneuropathies1CTD_human
TgeneC0271685Diabetic Amyotrophy1CTD_human
TgeneC0271686Diabetic Autonomic Neuropathy1CTD_human
TgeneC0276496Familial Alzheimer Disease (FAD)1CTD_human
TgeneC0393835Diabetic Asymmetric Polyneuropathy1CTD_human
TgeneC0458247Allodynia1CTD_human
TgeneC0494463Alzheimer Disease, Late Onset1CTD_human
TgeneC0546126Acute Confusional Senile Dementia1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC0750900Alzheimer's Disease, Focal Onset1CTD_human
TgeneC0750901Alzheimer Disease, Early Onset1CTD_human
TgeneC0751074Diabetic Neuralgia1CTD_human
TgeneC0751211Hyperalgesia, Primary1CTD_human
TgeneC0751212Hyperalgesia, Secondary1CTD_human
TgeneC0751213Tactile Allodynia1CTD_human
TgeneC0751214Hyperalgesia, Thermal1CTD_human
TgeneC0752347Lewy Body Disease1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC1855520Hyperglycemia, Postprandial1CTD_human
TgeneC2936719Mechanical Allodynia1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human