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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ZC3H7A-CD99 (FusionGDB2 ID:HG29066TG4267)

Fusion Gene Summary for ZC3H7A-CD99

check button Fusion gene summary
Fusion gene informationFusion gene name: ZC3H7A-CD99
Fusion gene ID: hg29066tg4267
HgeneTgene
Gene symbol

ZC3H7A

CD99

Gene ID

29066

4267

Gene namezinc finger CCCH-type containing 7ACD99 molecule (Xg blood group)
SynonymsHSPC055|ZC3H7|ZC3HDC7HBA71|MIC2|MIC2X|MIC2Y|MSK5X
Cytomap('ZC3H7A')('CD99')

16p13.13

Xp22.33 and Yp11.2

Type of geneprotein-codingprotein-coding
Descriptionzinc finger CCCH domain-containing protein 7Azinc finger CCCH-type domain containing 7zinc-finger protein AY163807CD99 antigenE2 antigenMIC2 (monoclonal antibody 12E7)T-cell surface glycoprotein E2antigen identified by monoclonal 12E7, Y homologantigen identified by monoclonal antibodies 12E7, F21 and O13cell surface antigen 12E7cell surface antigen HBA-71cel
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000355758, ENST00000396516, 
ENST00000575170, ENST00000575984, 
Fusion gene scores* DoF score10 X 13 X 7=91027 X 20 X 5=2700
# samples 1629
** MAII scorelog2(16/910*10)=-2.5077946401987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(29/2700*10)=-3.21883460192326
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ZC3H7A [Title/Abstract] AND CD99 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointZC3H7A(11868092)-CD99(2582463), # samples:2
Anticipated loss of major functional domain due to fusion event.ZC3H7A-CD99 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ZC3H7A-CD99 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ZC3H7A-CD99 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ZC3H7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CD99 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4V-01AZC3H7Achr16

11868092

-CD99chrX

2632463

+
ChimerDB4BLCATCGA-ZF-AA4V-01AZC3H7Achr16

11868092

-CD99chrY

2582463

+


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Fusion Gene ORF analysis for ZC3H7A-CD99

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000355758ENST00000482405ZC3H7Achr16

11868092

-CD99chrY

2582463

+
5CDS-3UTRENST00000396516ENST00000482405ZC3H7Achr16

11868092

-CD99chrY

2582463

+
5CDS-intronENST00000355758ENST00000381180ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000355758ENST00000381180ZC3H7Achr16

11868092

-CD99chrY

2582463

+
5CDS-intronENST00000355758ENST00000381184ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000355758ENST00000381187ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000355758ENST00000381192ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000355758ENST00000482405ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000396516ENST00000381180ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000396516ENST00000381180ZC3H7Achr16

11868092

-CD99chrY

2582463

+
5CDS-intronENST00000396516ENST00000381184ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000396516ENST00000381187ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000396516ENST00000381192ZC3H7Achr16

11868092

-CD99chrX

2632463

+
5CDS-intronENST00000396516ENST00000482405ZC3H7Achr16

11868092

-CD99chrX

2632463

+
Frame-shiftENST00000396516ENST00000381184ZC3H7Achr16

11868092

-CD99chrY

2582463

+
Frame-shiftENST00000396516ENST00000381187ZC3H7Achr16

11868092

-CD99chrY

2582463

+
Frame-shiftENST00000396516ENST00000381192ZC3H7Achr16

11868092

-CD99chrY

2582463

+
In-frameENST00000355758ENST00000381184ZC3H7Achr16

11868092

-CD99chrY

2582463

+
In-frameENST00000355758ENST00000381187ZC3H7Achr16

11868092

-CD99chrY

2582463

+
In-frameENST00000355758ENST00000381192ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575170ENST00000381184ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575170ENST00000381187ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575170ENST00000381192ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575984ENST00000381184ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575984ENST00000381187ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3CDSENST00000575984ENST00000381192ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3UTRENST00000575170ENST00000482405ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-3UTRENST00000575984ENST00000482405ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-intronENST00000575170ENST00000381180ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575170ENST00000381180ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-intronENST00000575170ENST00000381184ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575170ENST00000381187ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575170ENST00000381192ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575170ENST00000482405ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575984ENST00000381180ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575984ENST00000381180ZC3H7Achr16

11868092

-CD99chrY

2582463

+
intron-intronENST00000575984ENST00000381184ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575984ENST00000381187ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575984ENST00000381192ZC3H7Achr16

11868092

-CD99chrX

2632463

+
intron-intronENST00000575984ENST00000482405ZC3H7Achr16

11868092

-CD99chrX

2632463

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355758ZC3H7Achr1611868092-ENST00000381192CD99chrY2582463+207710811781179333
ENST00000355758ZC3H7Achr1611868092-ENST00000381187CD99chrY2582463+182110811781131317
ENST00000355758ZC3H7Achr1611868092-ENST00000381184CD99chrY2582463+185110811781179333

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355758ENST00000381192ZC3H7Achr1611868092-CD99chrY2582463+0.0010086740.9989913
ENST00000355758ENST00000381187ZC3H7Achr1611868092-CD99chrY2582463+0.0008870960.9991129
ENST00000355758ENST00000381184ZC3H7Achr1611868092-CD99chrY2582463+0.0013382440.99866176

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Fusion Genomic Features for ZC3H7A-CD99


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ZC3H7Achr1611868091-CD99chrY2582462+2.01E-161
ZC3H7Achr1611868091-CD99chrX2632462+2.01E-161
ZC3H7Achr1611868091-CD99chrY2582462+2.01E-161
ZC3H7Achr1611868091-CD99chrX2632462+2.01E-161

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ZC3H7A-CD99


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:11868092/chrY:2582463)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923124_156301972.0RepeatNote=TPR 3
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-92343_76301972.0RepeatNote=TPR 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-92389_122301972.0RepeatNote=TPR 2
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822124_156301972.0RepeatNote=TPR 3
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-82243_76301972.0RepeatNote=TPR 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-82289_122301972.0RepeatNote=TPR 2
TgeneCD99chr16:11868092chrY:2582463ENST0000038118709148_18522170.0Topological domainCytoplasmic
TgeneCD99chr16:11868092chrY:2582463ENST000003811870923_12222170.0Topological domainExtracellular
TgeneCD99chr16:11868092chrY:2582463ENST00000381192010148_18522186.0Topological domainCytoplasmic
TgeneCD99chr16:11868092chrY:2582463ENST0000038119201023_12222186.0Topological domainExtracellular
TgeneCD99chr16:11868092chrY:2582463ENST0000038118709123_14722170.0TransmembraneHelical
TgeneCD99chr16:11868092chrY:2582463ENST00000381192010123_14722186.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923924_952301972.0Coiled coilOntology_term=ECO:0000255
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822924_952301972.0Coiled coilOntology_term=ECO:0000255
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14924_9520168.0Coiled coilOntology_term=ECO:0000255
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14124_1560168.0RepeatNote=TPR 3
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-1443_760168.0RepeatNote=TPR 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-1489_1220168.0RepeatNote=TPR 2
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923634_656301972.0Zinc fingerC3H1-type 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923769_797301972.0Zinc fingerC3H1-type 2
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923857_881301972.0Zinc fingerNote=C2H2-type
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000355758-923906_928301972.0Zinc fingerC3H1-type 3
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822634_656301972.0Zinc fingerC3H1-type 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822769_797301972.0Zinc fingerC3H1-type 2
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822857_881301972.0Zinc fingerNote=C2H2-type
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000396516-822906_928301972.0Zinc fingerC3H1-type 3
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14634_6560168.0Zinc fingerC3H1-type 1
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14769_7970168.0Zinc fingerC3H1-type 2
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14857_8810168.0Zinc fingerNote=C2H2-type
HgeneZC3H7Achr16:11868092chrY:2582463ENST00000575984-14906_9280168.0Zinc fingerC3H1-type 3


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Fusion Gene Sequence for ZC3H7A-CD99


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>100579_100579_1_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381184_length(transcript)=1851nt_BP=1081nt
AACCGAGCCGCTGCCGCCGCCGCTAACCGAGGGAGAGCTGCGAGCGAGCACCCAGGCCCCGCCGCCGCCGCCGCCACCGCTGCCCGCCTG
CCGCCGCCCGCCTCCGCCTGCCTTCTGCCGCCGGCCGGCGCGTCGTCCCCACAGATTGCTCATTTAGAAAGTGGATGTGTGGGATAACAT
GTCCAATGTGTCCGAGGAGAGAAGAAAAAGGCAGCAGAACATTAAGGAAGGACTGCAGTTTATACAGTCACCGCTGTCATATCCAGGAAC
ACAGGAGCAATATGCGGTATATTTGCGTGCTCTCGTGAGAAATCTTTTTAATGAAGGAAATGACGTTTATCGGGAACATGATTGGAACAA
CTCGATAAGCCAGTACACGGAAGCCTTGAATATAGCTGATTATGCAAAATCTGAAGAAATTTTAATCCCCAAAGAAATAATTGAAAAACT
ATATATAAATCGTATTGCCTGCTATTCTAATATGGGTTTCCATGATAAAGTTTTGGAGGACTGCAATATAGTCCTCAGTTTAAATGCCAG
TAACTGCAAAGCTCTGTATCGGAAATCTAAGGCTTTAAGTGATTTAGGAAGATACAAAAAGGCTTACGATGCTGTAGCAAAGTGCTCCTT
AGCAGTGCCTCAGGATGAGCATGTAATAAAACTAACTCAAGAACTAGCTCAGAAATTGGGATTTAAAATAAGAAAAGCGTATGTCAGAGC
TGAGCTCTCATTAAAATCAGTTCCTGGGGATGGGGCTACCAAGGCTTTGAACCATTCTGTGGAAGATATTGAGCCAGATTTATTAACTCC
AAGGCAAGAAGCAGTTCCTGTTGTCTCTTTACCGGCACCCAGTTTTTCTCATGAAGTTGGAAGTGAGCTGGCCTCAGTTCCTGTTATGCC
CTTAACTTCTATTTTGCCACTACAAGTGGAAGAGAGCGCTCTGCCATCTGCAGTGCTGGCAAATGGAGGAAAGATGCCCTTCACTATGCC
AGAAGCTTTTCTAGATGATGGAGATATGGTCCTTGGAGATGAACTAGATGACCTGCTTGATTCTGCACCTGAAACTAATGAAACTGTTAT
GATGGTGGTTTCGATTTATCCGATGCCCTTCCTGACAATGAAAACAAGAAACCCACTGCAATCCCCAAGAAACCCAGTGCTGGGGATGAC
TTTGACTTAGGAGATGCTGTTGTTGATGGAGAAAATGACGACCCACGACCACCGAACCCACCCAAACCGATGCCAAATCCAAACCCCAAC
CACCCTAGTTCCTCCGGTAGCTTTTCAGATGCTGACCTTGCGGATGGCGTTTCAGGTGGAGAAGGAAAAGGAGGCAGTGATGGTGGAGGC
AGCCACAGGAAAGAAGGGGAAGAGGCCGACGCCCCAGGCGTGATCCCCGGGATTGTGGGGGCTGTCGTGGTCGCCGTGGCTGGAGCCATC
TCTAGCTTCATTGCTTACCAGAAAAAGAAGCTATGCTTCAAAGAAAATGGTCAGCTGGCAGGCTCTTTGGGACCTTGTATTGGGATCCGC
CGTGAAGCTGATGGCTGAAGACCTAGGGGTGAGCAGAGAACCCAGCCCAGGCCTGCGGAGCGTCCTGACCGTAATCGTTTTATCTGCTAA
GACATAGCCTTAAAGCAAACCCTTCCATCTGCCGCTCCCCTCGCCCTGCTGGCAAATTCCCACCACGATGGGATTCTCAATCACATGGCG
GATTCTCTGCCTTCAGTTCCATATGCTTTTGCCTTTCTGGATGCACAGAAGCTCATTATAGCAAATCATATTTCTGCATAAGAGCTTCAG

>100579_100579_1_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381184_length(amino acids)=333AA_BP=301
MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWNNSISQYTEALNIADYAKSEEILIPKEIIEK
LYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVR
AELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPSFSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTM

--------------------------------------------------------------
>100579_100579_2_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381187_length(transcript)=1821nt_BP=1081nt
AACCGAGCCGCTGCCGCCGCCGCTAACCGAGGGAGAGCTGCGAGCGAGCACCCAGGCCCCGCCGCCGCCGCCGCCACCGCTGCCCGCCTG
CCGCCGCCCGCCTCCGCCTGCCTTCTGCCGCCGGCCGGCGCGTCGTCCCCACAGATTGCTCATTTAGAAAGTGGATGTGTGGGATAACAT
GTCCAATGTGTCCGAGGAGAGAAGAAAAAGGCAGCAGAACATTAAGGAAGGACTGCAGTTTATACAGTCACCGCTGTCATATCCAGGAAC
ACAGGAGCAATATGCGGTATATTTGCGTGCTCTCGTGAGAAATCTTTTTAATGAAGGAAATGACGTTTATCGGGAACATGATTGGAACAA
CTCGATAAGCCAGTACACGGAAGCCTTGAATATAGCTGATTATGCAAAATCTGAAGAAATTTTAATCCCCAAAGAAATAATTGAAAAACT
ATATATAAATCGTATTGCCTGCTATTCTAATATGGGTTTCCATGATAAAGTTTTGGAGGACTGCAATATAGTCCTCAGTTTAAATGCCAG
TAACTGCAAAGCTCTGTATCGGAAATCTAAGGCTTTAAGTGATTTAGGAAGATACAAAAAGGCTTACGATGCTGTAGCAAAGTGCTCCTT
AGCAGTGCCTCAGGATGAGCATGTAATAAAACTAACTCAAGAACTAGCTCAGAAATTGGGATTTAAAATAAGAAAAGCGTATGTCAGAGC
TGAGCTCTCATTAAAATCAGTTCCTGGGGATGGGGCTACCAAGGCTTTGAACCATTCTGTGGAAGATATTGAGCCAGATTTATTAACTCC
AAGGCAAGAAGCAGTTCCTGTTGTCTCTTTACCGGCACCCAGTTTTTCTCATGAAGTTGGAAGTGAGCTGGCCTCAGTTCCTGTTATGCC
CTTAACTTCTATTTTGCCACTACAAGTGGAAGAGAGCGCTCTGCCATCTGCAGTGCTGGCAAATGGAGGAAAGATGCCCTTCACTATGCC
AGAAGCTTTTCTAGATGATGGAGATATGGTCCTTGGAGATGAACTAGATGACCTGCTTGATTCTGCACCTGAAACTAATGAAACTGTTAT
GATGGTGGTTTCGATTTATCCGATGCCCTTCCTGGGGATGACTTTGACTTAGGAGATGCTGTTGTTGATGGAGAAAATGACGACCCACGA
CCACCGAACCCACCCAAACCGATGCCAAATCCAAACCCCAACCACCCTAGTTCCTCCGGTAGCTTTTCAGATGCTGACCTTGCGGATGGC
GTTTCAGGTGGAGAAGGAAAAGGAGGCAGTGATGGTGGAGGCAGCCACAGGAAAGAAGGGGAAGAGGCCGACGCCCCAGGCGTGATCCCC
GGGATTGTGGGGGCTGTCGTGGTCGCCGTGGCTGGAGCCATCTCTAGCTTCATTGCTTACCAGAAAAAGAAGCTATGCTTCAAAGAAAAT
GCAGAACAAGGGGAGGTGGACATGGAGAGCCACCGGAATGCCAACGCAGAGCCAGCTGTTCAGCGTACTCTTTTAGAGAAATAGAAGATT
GTCGGCAGAAACAGCCCAGGCGTTGGCAGCAGGGTTAGAACAGCTGCCTGAGGCTCCTCCCTGAAGGACACCTGCCTGAGAGCAGAGATG
GAGGCCTTCTGTTCACGGCGGATTCTTTGTTTTAATCTTGCGATGTGCTTTGCTTGTTGCTGGGCGGATGATGTTTACTAACGATGAATT
TTACATCCAAAGGGGGATAGGCACTTGGACCCCCATTCTCCAAGGCCCGGGGGGGCGGTTTCCCATGGGATGTGAAAGGCTGGCCATTAT

>100579_100579_2_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381187_length(amino acids)=317AA_BP=
MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWNNSISQYTEALNIADYAKSEEILIPKEIIEK
LYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVR
AELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPSFSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTM

--------------------------------------------------------------
>100579_100579_3_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381192_length(transcript)=2077nt_BP=1081nt
AACCGAGCCGCTGCCGCCGCCGCTAACCGAGGGAGAGCTGCGAGCGAGCACCCAGGCCCCGCCGCCGCCGCCGCCACCGCTGCCCGCCTG
CCGCCGCCCGCCTCCGCCTGCCTTCTGCCGCCGGCCGGCGCGTCGTCCCCACAGATTGCTCATTTAGAAAGTGGATGTGTGGGATAACAT
GTCCAATGTGTCCGAGGAGAGAAGAAAAAGGCAGCAGAACATTAAGGAAGGACTGCAGTTTATACAGTCACCGCTGTCATATCCAGGAAC
ACAGGAGCAATATGCGGTATATTTGCGTGCTCTCGTGAGAAATCTTTTTAATGAAGGAAATGACGTTTATCGGGAACATGATTGGAACAA
CTCGATAAGCCAGTACACGGAAGCCTTGAATATAGCTGATTATGCAAAATCTGAAGAAATTTTAATCCCCAAAGAAATAATTGAAAAACT
ATATATAAATCGTATTGCCTGCTATTCTAATATGGGTTTCCATGATAAAGTTTTGGAGGACTGCAATATAGTCCTCAGTTTAAATGCCAG
TAACTGCAAAGCTCTGTATCGGAAATCTAAGGCTTTAAGTGATTTAGGAAGATACAAAAAGGCTTACGATGCTGTAGCAAAGTGCTCCTT
AGCAGTGCCTCAGGATGAGCATGTAATAAAACTAACTCAAGAACTAGCTCAGAAATTGGGATTTAAAATAAGAAAAGCGTATGTCAGAGC
TGAGCTCTCATTAAAATCAGTTCCTGGGGATGGGGCTACCAAGGCTTTGAACCATTCTGTGGAAGATATTGAGCCAGATTTATTAACTCC
AAGGCAAGAAGCAGTTCCTGTTGTCTCTTTACCGGCACCCAGTTTTTCTCATGAAGTTGGAAGTGAGCTGGCCTCAGTTCCTGTTATGCC
CTTAACTTCTATTTTGCCACTACAAGTGGAAGAGAGCGCTCTGCCATCTGCAGTGCTGGCAAATGGAGGAAAGATGCCCTTCACTATGCC
AGAAGCTTTTCTAGATGATGGAGATATGGTCCTTGGAGATGAACTAGATGACCTGCTTGATTCTGCACCTGAAACTAATGAAACTGTTAT
GATGGTGGTTTCGATTTATCCGATGCCCTTCCTGACAATGAAAACAAGAAACCCACTGCAATCCCCAAGAAACCCAGTGCTGGGGATGAC
TTTGACTTAGGAGATGCTGTTGTTGATGGAGAAAATGACGACCCACGACCACCGAACCCACCCAAACCGATGCCAAATCCAAACCCCAAC
CACCCTAGTTCCTCCGGTAGCTTTTCAGATGCTGACCTTGCGGATGGCGTTTCAGGTGGAGAAGGAAAAGGAGGCAGTGATGGTGGAGGC
AGCCACAGGAAAGAAGGGGAAGAGGCCGACGCCCCAGGCGTGATCCCCGGGATTGTGGGGGCTGTCGTGGTCGCCGTGGCTGGAGCCATC
TCTAGCTTCATTGCTTACCAGAAAAAGAAGCTATGCTTCAAAGAAAATGCAGAACAAGGGGAGGTGGACATGGAGAGCCACCGGAATGCC
AACGCAGAGCCAGCTGTTCAGCGTACTCTTTTAGAGAAATAGAAGATTGTCGGCAGAAACAGCCCAGGCGTTGGCAGCAGGGTTAGAACA
GCTGCCTGAGGCTCCTCCCTGAAGGACACCTGCCTGAGAGCAGAGATGGAGGCCTTCTGTTCACGGCGGATTCTTTGTTTTAATCTTGCG
ATGTGCTTTGCTTGTTGCTGGGCGGATGATGTTTACTAACGATGAATTTTACATCCAAAGGGGGATAGGCACTTGGACCCCCATTCTCCA
AGGCCCGGGGGGGCGGTTTCCCATGGGATGTGAAAGGCTGGCCATTATTAAGTCCCTGTAACTCAAATGTCAACCCCACCGAGGCACCCC
CCCGTCCCCCAGAATCTTGGCTGTTTACAAATCACGTGTCCATCGAGCACGTCTGAAACCCCTGGTAGCCCCGACTTCTTTTTAATTAAA
ATAAGGTAAGCCCTTCAATTTGTTTCTTCAATATTTCTTTCATTTGTAGGGATATTTGTTTTTCATATCAGACTAATAAAAAGAAATTAG

>100579_100579_3_ZC3H7A-CD99_ZC3H7A_chr16_11868092_ENST00000355758_CD99_chrY_2582463_ENST00000381192_length(amino acids)=333AA_BP=301
MSNVSEERRKRQQNIKEGLQFIQSPLSYPGTQEQYAVYLRALVRNLFNEGNDVYREHDWNNSISQYTEALNIADYAKSEEILIPKEIIEK
LYINRIACYSNMGFHDKVLEDCNIVLSLNASNCKALYRKSKALSDLGRYKKAYDAVAKCSLAVPQDEHVIKLTQELAQKLGFKIRKAYVR
AELSLKSVPGDGATKALNHSVEDIEPDLLTPRQEAVPVVSLPAPSFSHEVGSELASVPVMPLTSILPLQVEESALPSAVLANGGKMPFTM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ZC3H7A-CD99


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ZC3H7A-CD99


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ZC3H7A-CD99


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0206637Mesenchymal Chondrosarcoma1CTD_human