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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ANKRD11-NAALADL2 (FusionGDB2 ID:HG29123TG254827)

Fusion Gene Summary for ANKRD11-NAALADL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD11-NAALADL2
Fusion gene ID: hg29123tg254827
HgeneTgene
Gene symbol

ANKRD11

NAALADL2

Gene ID

29123

254827

Gene nameankyrin repeat domain 11N-acetylated alpha-linked acidic dipeptidase like 2
SynonymsANCO-1|ANCO1|LZ16|T13-
Cytomap('ANKRD11')('NAALADL2')

16q24.3

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 11ankyrin repeat-containing cofactor 1nasopharyngeal carcinoma susceptibility proteintruncated ankyrin repeat domain 11 aberrant transcript 1truncated ankyrin repeat domain 11 aberrant transcript 2inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue
Modification date2020031320200313
UniProtAcc.

Q58DX5

Ensembl transtripts involved in fusion geneENST00000301030, ENST00000378330, 
ENST00000563291, ENST00000567736, 
Fusion gene scores* DoF score42 X 20 X 20=1680021 X 16 X 9=3024
# samples 5624
** MAII scorelog2(56/16800*10)=-4.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/3024*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD11 [Title/Abstract] AND NAALADL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointANKRD11(89357033)-NAALADL2(174951721), # samples:1
Anticipated loss of major functional domain due to fusion event.ANKRD11-NAALADL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD11-NAALADL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD11-NAALADL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NAALADL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-IW-A3M5-01AANKRD11chr16

89357033

-NAALADL2chr3

174951721

+


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Fusion Gene ORF analysis for ANKRD11-NAALADL2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000301030ENST00000473253ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
5CDS-3UTRENST00000378330ENST00000473253ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
Frame-shiftENST00000378330ENST00000454872ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
In-frameENST00000301030ENST00000454872ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
intron-3CDSENST00000563291ENST00000454872ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
intron-3CDSENST00000567736ENST00000454872ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
intron-3UTRENST00000563291ENST00000473253ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+
intron-3UTRENST00000567736ENST00000473253ANKRD11chr16

89357033

-NAALADL2chr3

174951721

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000301030ANKRD11chr1689357033-ENST00000454872NAALADL2chr3174951721+5342106210662904612

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000301030ENST00000454872ANKRD11chr1689357033-NAALADL2chr3174951721+0.0005382920.9994617

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Fusion Genomic Features for ANKRD11-NAALADL2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ANKRD11chr1689357032-NAALADL2chr3174951720+0.0001075890.99989235
ANKRD11chr1689357032-NAALADL2chr3174951720+0.0001075890.99989235

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ANKRD11-NAALADL2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:89357033/chr3:174951721)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NAALADL2

Q58DX5

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be catalytically inactive.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613167_1962002664.0RepeatNote=ANK 1
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714167_1962002664.0RepeatNote=ANK 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-6131824_23652002664.0Compositional biasNote=Pro-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613478_5882002664.0Compositional biasNote=Ser-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613621_16552002664.0Compositional biasNote=Lys-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-7141824_23652002664.0Compositional biasNote=Pro-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714478_5882002664.0Compositional biasNote=Ser-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714621_16552002664.0Compositional biasNote=Lys-rich
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-6132369_26632002664.0RegionImportant for protein degradation
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-7142369_26632002664.0RegionImportant for protein degradation
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613200_2292002664.0RepeatNote=ANK 2
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613233_2622002664.0RepeatNote=ANK 3
HgeneANKRD11chr16:89357033chr3:174951721ENST00000301030-613266_2922002664.0RepeatNote=ANK 4
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714200_2292002664.0RepeatNote=ANK 2
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714233_2622002664.0RepeatNote=ANK 3
HgeneANKRD11chr16:89357033chr3:174951721ENST00000378330-714266_2922002664.0RepeatNote=ANK 4
TgeneNAALADL2chr16:89357033chr3:174951721ENST00000454872114143_795181796.0Topological domainExtracellular
TgeneNAALADL2chr16:89357033chr3:174951721ENST000004548721141_121181796.0Topological domainCytoplasmic
TgeneNAALADL2chr16:89357033chr3:174951721ENST00000454872114122_142181796.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ANKRD11-NAALADL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>4553_4553_1_ANKRD11-NAALADL2_ANKRD11_chr16_89357033_ENST00000301030_NAALADL2_chr3_174951721_ENST00000454872_length(transcript)=5342nt_BP=1062nt
AGAGGCCGCCCTGAGACGGTGCGCGATGGACCGAGGGCCCCAGCCGGGGAGGCGCCGCCGCCGAGCCCGCGGCCAGACGCCCCATCAGTA
GCGTCCGCACCGGGAGCCGCGGCTCTCGCCCGAGCCGTGGGCGCGCCCGAGGGGCGGGCTCGCCTCCCGCCGTCCCTCGCAGCTCTGCCG
GGCCCGAGCCCGCGCCGCCGCCGCCGCCGCCTTGCCGCTCGGGCCGCGCGGCCCGGGAAACGCGGCCGCGGGCTGCATGGGCAGCGCCCG
CGCCCCGCCGCTGAGCCGTCGCGGAGCCGCGCAGCCCTCGGAGCACGAATATATACAGCCCTGCTCTGGGACACACCTCCATTGGATTTA
AAAGACAGTCCTCGTCAGCACTGACTTTCAGCTATGGAATCGCAGACGGTTGATGATGAAGCGCCGGCCGTGTAAATGAAGATCGGGTGA
GGAGCAGGACGATGCCCAAGGGTGGGTGCCCTAAAGCACCACAGCAGGAAGAGCTTCCCCTCAGCAGCGACATGGTGGAGAAGCAGACTG
GGAAAAAGGATAAAGATAAAGTTTCTCTAACCAAGACCCCAAAACTGGAGCGTGGCGATGGCGGGAAGGAGGTGAGGGAGCGAGCCAGCA
AGCGGAAGCTGCCCTTCACCGCGGGCGCCAATGGGGAGCAGAAGGACTCGGACACAGAGAAGCAGGGCCCTGAGCGGAAGAGGATTAAGA
AGGAGCCTGTCACCCGGAAGGCCGGGCTGCTGTTTGGCATGGGGCTGTCTGGAATCCGAGCCGGCTACCCCCTCTCCGAGCGCCAGCAGG
TGGCCCTTCTCATGCAGATGACGGCCGAGGAGTCTGCCAACAGCCCAGTGGACACAACACCAAAGCACCCCTCCCAGTCTACAGTGTGTC
AGAAGGGAACGCCCAACTCTGCCTCAAAAACCAAAGATAAAGTGAACAAGAGAAACGAGCGTGGAGAGACCCGCCTGCACCGAGCCGCCA
TCCGCGGGGACGCCCGGCGCATCAAAGAGCTCATCAGCGAGGGGGCAGACGTCAACGTCAAGGACTTCGCAGAAATTTGGTACAACTATA
TAAAAATGAAGATGACATGGAAATTTCAAAGAAGATTAAGACTCAGTGGACCTCTTTGGGCCTAGAAGATGTACAGTTTGTAAATTACTC
TGTGCTGCTTGATCTGCCAGGCCCTTCTCCCAGCACTGTGACTCTGAGCAGCAGTGGTCAATGCTTTCATCCTAATGGCCAGCCTTGCAG
TGAAGAAGCCAGAAAAGATAGCAGCCAAGACCTGCTCTATTCATATGCAGCCTATTCTGCCAAAGGAACTCTCAAGGCTGAAGTCATCGA
TGTGAGTTATGGAATGGCAGATGATTTAAAAAGGATTAGGAAAATAAAAAACGTAACAAATCAGATCGCACTCCTGAAATTAGGAAAATT
GCCACTGCTTTATAAGCTTTCCTCATTGGAAAAGGCTGGATTTGGAGGTGTTCTTCTGTATATCGATCCTTGTGATTTGCCAAAGACTGT
GAATCCTAGCCATGATACCTTCATGGTGTCACTGAATCCAGGAGGAGACCCTTCTACGCCTGGTTACCCAAGTGTCGATGAAAGTTTTAG
ACAAAGCCGATCAAACCTCACCTCTCTATTAGTGCAGCCCATCTCTGCACCCCTCGTTGCAAAACTGATCTCTTCGCCAAAAGCTAGAAC
CAAAAATGAAGCGTGTAGCTCTCTAGAGCTTCCAAATAATGAAATAAGAGTCGTCAGCATGCAAGTTCAGACAGTCACAAAATTGAAAAC
AGTTACTAATGTTGTTGGATTTGTAATGGGCTTGACATCTCCAGACCGGTATATCATAGTTGGCAGCCATCATCACACTGCACACAGTTA
TAATGGACAAGAATGGGCCAGTAGTACTGCAATAATCACAGCGTTTATCCGTGCCTTGATGTCAAAAGTTAAGAGAGGGTGGAGACCAGA
CCGAACTATTGTTTTCTGTTCTTGGGGAGGAACAGCTTTTGGCAATATTGGCTCATATGAATGGGGAGAGGATTTCAAGAAGGTTCTTCA
GAAAAATGTTGTGGCTTATATTAGCCTCCACAGTCCCATAAGGGGGAACTCTAGTCTGTATCCTGTAGCATCACCATCTCTTCAGCAACT
GGTAGTAGAGAAAAATAATTTCAACTGTACCAGAAGAGCCCAGTGCCCAGAAACCAATATCAGTTCTATACAGATACAAGGTGATGCTGA
TTATTTCATCAACCATCTTGGAGTTCCCATCGTGCAGTTTGCTTACGAGGACATCAAAACATTAGAGGGTCCAAGTTTTCTCTCCGAGGC
CCGTTTTTCTACACGAGCAACAAAAATTGAAGAAATGGATCCCTCTTTCAACCTTCATGAAACCATTACTAAGCTCTCAGGAGAAGTGAT
TTTGCAAATTGCCAACGAACCTGTTCTGCCCTTTAATGCACTTGATATAGCTTTAGAAGTTCAAAACAACCTTAAAGGTGATCAACCCAA
CACTCATCAACTGTTAGCCATGGCGTTACGCCTGCGGGAGAGTGCTGAACTTTTTCAGTCTGATGAGATGCGACCTGCTAATGATCCCAA
GGAGAGAGCACCCATCCGCATCCGGATGCTGAATGACATTCTCCAAGACATGGAGAAAAGCTTTCTGGTAAAGCAGGCACCACCAGGTTT
TTATAGAAACATCCTCTACCACCTTGATGAAAAGACAAGCCGGTTTTCAATACTTATAGAGGCTTGGGAACACTGCAAACCCCTTGCATC
AAATGAGACCCTTCAAGAAGCCCTGTCAGAGGTGTTGAACAGCATTAATTCAGCTCAGGTTTACTTCAAAGCAGGACTTGATGTGTTCAA
GAGTGTCTTGGATGGGAAGAATTGAGAAAACTCTGAGCATTTTTAAAAGTTTGTTTACAATTCCACAAGCAAAAGCTCTAATTTAACCAG
ATTTTCTGACATTGAAGGCTTATTTTCCCCAATGGCTTTTTGACAAGTATAAAGCTATTATTACATTGTATTTTTTAAATGTAAATATAG
AAAGAACATTTTGCACATTTAATATTTTTCTTATATCTACATTTCTGAATATGTAAAGCAAGTTATTGAAATAGGACTTAAGAATTACCT
ATTAAAAAGAAATCTGATATATAAAAATATGTACTATTTTAAGGAAAAATTTCCAAGAAGTTCTGGACTATCTTTGTTCCTATGGGGAGG
GCATATAGGAACACAGTTTATTCTCTCTGATAGAGCTATTAATGACTTAGTTTCTGTAAAAGAAATGGAGAGTTGATATGGTTCAGATTA
ACTTCACTATTAAGTGTTCAATATGAAGAATTCAAGTATTCTGACTGAGTGATTGGTTGACCTAAACCACTTTGAATGTTTCTATTTTAT
GAAATGAAGTTTCTCTTCTTAACACAACTAGATGTAGTAATACACTGGTTATGAAATTGTATTTTTTTAAGTATTAATGAAAAAAGAGCC
ATAAGCATTCCAGGAGAAAATCTCAAGGGAGCTACATAGAGCAATTTAAATGCAAATTTTTTTCCTAACAACTTACAAGGTGACTAGCTT
TGAAACCCCTAATTTGCCTCAGTTGATTTTCTAAGAATTTCAGGAGTGATGTATGTCTTAAGAGGGAGAAAAAAATATTTCTTATTACTT
TTTCTCTTGTTTCTGTTGGAAACACTGAAGCAGGGACTCTAAAATGAAAGCATCTCACATTGGTTTTCTTTCTTGTATCTTTTCTGAAAC
TCCTTGCTGTAAGGCAGCTTTCTCAGAGTACTATATATTTTCAACAGTAAAGTAGCAGAGTTTCTCTTTGAAACCCAAAATGTCTTCTAA
AGAATCAAATTTCTATTTCTGCCTCTGACAAAAAGAACTTACTATGAAAGAAATAGTTGTTTTATCAATAAAAGCCCCTTAATATTATGA
AGAAACTTTTCATATTTTTTCTTCTTTATCCTTAATTGTGACTAAGATGGAAATCTAGAAAATATTCATGCTTCTAAGTTTCTGCAGTGT
TACTGTAAGAGAGTGTCTCGTCTACACTTCAGTTCTTCTCTCATGTGGAAAACTAAGCTTTTTATATTGACATTGCCATTGAATAGCTCT
AGCAACTATTATTATTCCCCCAAACCCTAAAATTCTACCTATTAGGTGTCAGGTTAAAGTTCTAATTTATCTTTAGAAATTTATGTGAAA
AATGGTTTTCCTATACTGGATAAAGCAATTCCCCTTAGGAAACATAGCCTCAGAGTATTTCATATAAATTTTCTCTATCTAATTCAAACA
TATCTCCCCATGATACACCGCCAGAGTGACATTGCAGACAGTCTGTGTATGTTTAAATTTTCACTTTTTATGGATGAGCATAAACCTAGT
CTTAGTTTAAAGGCAAACTAAAGTTGAGGGGAAATAATTAATCAATACTGATTAATTGATTTATAAGGTTCAACACTGTCTACCCTAAAT
AATTTTTATATGCTCAAGGCAAAGCAGGGAATAGAGGCAATTAGCTAGATAATTCAAGCAGAAATCCATTTTCATCGAAATTGCCTGTGT
GCACATATTTTTAGATGAAAAATGAAACTACCTTACAATATTATTTTTTTAACCAATGTATTTGTTTGCAAACATTTGCCATGTTGAAGA
GTGTGTATAGGAAAGGTCTAGAAATAAATAGGCTTGTGCATACCTAGGCATTCATGCTCTTTCTTCCTCTTCAGAGATCATCAGAAAAGA
GGTGGGAATACACAAGCAGGTGCATGTAAGCCCAAAAGCTAGAAAGCCTTATATTTAACCAAAGGTTGATGTGTTCATTCCAGTTATTCA
CTTACAGATGAAACTAAAACAAATAAAGGCAAGCTATTATCAGTTTGGTAGTTCATTATTTTAGAACAAATTTCTAAATTAATTTATTCC
CATAACCTACAATAGCACTGAGAACAGAAAACATGTTTCTTCTTCATTTTGTTTAAAGATTGCGTACCTAGGTAAGTCACACTGTATAGA
TAAAAACCTTCTTCTGTATTCCTCACCTCTAAATTATATGTTATTTGCTATTTGAAAACTGTAGTTAACTATGGTTTTTTATTAGTCTAT
TAAAAGATACGTGGAGATATTAAATTATACCTAAAGCAGACGTCCAACAAATTCTGTACATGCTGCTTTACATCTTTGCAACAAACCTCT
TAACTAGCAGCATTATTTCTATAGTGTGATTACCTGAGGGTGCCTCCAAATGTATATCATTTCACTCCCCTCCCCTCCCCACCCCCAATA
GATTCAAATAAATAAAATCCTGAGCAAATTAA

>4553_4553_1_ANKRD11-NAALADL2_ANKRD11_chr16_89357033_ENST00000301030_NAALADL2_chr3_174951721_ENST00000454872_length(amino acids)=612AA_BP=1
MVQLYKNEDDMEISKKIKTQWTSLGLEDVQFVNYSVLLDLPGPSPSTVTLSSSGQCFHPNGQPCSEEARKDSSQDLLYSYAAYSAKGTLK
AEVIDVSYGMADDLKRIRKIKNVTNQIALLKLGKLPLLYKLSSLEKAGFGGVLLYIDPCDLPKTVNPSHDTFMVSLNPGGDPSTPGYPSV
DESFRQSRSNLTSLLVQPISAPLVAKLISSPKARTKNEACSSLELPNNEIRVVSMQVQTVTKLKTVTNVVGFVMGLTSPDRYIIVGSHHH
TAHSYNGQEWASSTAIITAFIRALMSKVKRGWRPDRTIVFCSWGGTAFGNIGSYEWGEDFKKVLQKNVVAYISLHSPIRGNSSLYPVASP
SLQQLVVEKNNFNCTRRAQCPETNISSIQIQGDADYFINHLGVPIVQFAYEDIKTLEGPSFLSEARFSTRATKIEEMDPSFNLHETITKL
SGEVILQIANEPVLPFNALDIALEVQNNLKGDQPNTHQLLAMALRLRESAELFQSDEMRPANDPKERAPIRIRMLNDILQDMEKSFLVKQ
APPGFYRNILYHLDEKTSRFSILIEAWEHCKPLASNETLQEALSEVLNSINSAQVYFKAGLDVFKSVLDGKN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ANKRD11-NAALADL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ANKRD11-NAALADL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ANKRD11-NAALADL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneANKRD11C0220687KBG syndrome13CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneANKRD11C1535926Neurodevelopmental Disorders2CTD_human
HgeneANKRD11C0005944Metabolic Bone Disorder1CTD_human
HgeneANKRD11C0014544Epilepsy1CTD_human
HgeneANKRD11C0029453Osteopenia1CTD_human
HgeneANKRD11C0086237Epilepsy, Cryptogenic1CTD_human
HgeneANKRD11C0236018Aura1CTD_human
HgeneANKRD11C0751111Awakening Epilepsy1CTD_human
HgeneANKRD11C1510586Autism Spectrum Disorders1CTD_human