Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:CD274-KDM4C (FusionGDB2 ID:HG29126TG23081)

Fusion Gene Summary for CD274-KDM4C

check button Fusion gene summary
Fusion gene informationFusion gene name: CD274-KDM4C
Fusion gene ID: hg29126tg23081
HgeneTgene
Gene symbol

CD274

KDM4C

Gene ID

29126

23081

Gene nameCD274 moleculelysine demethylase 4C
SynonymsB7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1|hPD-L1GASC1|JHDM3C|JMJD2C|TDRD14C
Cytomap('CD274')('KDM4C')

9p24.1

9p24.1

Type of geneprotein-codingprotein-coding
Descriptionprogrammed cell death 1 ligand 1B7 homolog 1CD274 antigenPDCD1 ligand 1lysine-specific demethylase 4CJmjC domain-containing histone demethylation protein 3Cgene amplified in squamous cell carcinoma 1 proteinjumonji domain-containing protein 2Clysine (K)-specific demethylase 4Ctudor domain containing 14C
Modification date2020032920200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000381573, ENST00000381577, 
ENST00000498261, 
Fusion gene scores* DoF score3 X 2 X 2=1222 X 22 X 7=3388
# samples 326
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(26/3388*10)=-3.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD274 [Title/Abstract] AND KDM4C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD274(5465606)-KDM4C(6792971), # samples:1
Anticipated loss of major functional domain due to fusion event.CD274-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD274-KDM4C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD274-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD274-KDM4C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD274

GO:0006955

immune response

10581077

HgeneCD274

GO:0007165

signal transduction

10581077

HgeneCD274

GO:0007166

cell surface receptor signaling pathway

10581077

HgeneCD274

GO:0031295

T cell costimulation

10581077

HgeneCD274

GO:0034097

response to cytokine

17489864

HgeneCD274

GO:1905399

regulation of activated CD4-positive, alpha-beta T cell apoptotic process

24187568

HgeneCD274

GO:1905404

positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process

24187568

HgeneCD274

GO:2000562

negative regulation of CD4-positive, alpha-beta T cell proliferation

24691993

HgeneCD274

GO:2001181

positive regulation of interleukin-10 secretion

10581077

TgeneKDM4C

GO:0006357

regulation of transcription by RNA polymerase II

17277772

TgeneKDM4C

GO:0033169

histone H3-K9 demethylation

18066052|21914792

TgeneKDM4C

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across CD274 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across KDM4C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-6706CD274chr9

5465606

+KDM4Cchr9

6792971

+


Top

Fusion Gene ORF analysis for CD274-KDM4C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000381573ENST00000489243CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-3UTRENST00000381577ENST00000489243CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000381306CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000381309CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000401787CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000442236CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000536108CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381573ENST00000543771CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000381306CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000381309CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000401787CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000442236CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000536108CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-5UTRENST00000381577ENST00000543771CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-intronENST00000381573ENST00000428870CD274chr9

5465606

+KDM4Cchr9

6792971

+
5CDS-intronENST00000381577ENST00000428870CD274chr9

5465606

+KDM4Cchr9

6792971

+
In-frameENST00000381573ENST00000535193CD274chr9

5465606

+KDM4Cchr9

6792971

+
In-frameENST00000381577ENST00000535193CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-3CDSENST00000498261ENST00000535193CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-3UTRENST00000498261ENST00000489243CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000381306CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000381309CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000401787CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000442236CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000536108CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-5UTRENST00000498261ENST00000543771CD274chr9

5465606

+KDM4Cchr9

6792971

+
intron-intronENST00000498261ENST00000428870CD274chr9

5465606

+KDM4Cchr9

6792971

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000381573CD274chr95465606+ENST00000535193KDM4Cchr96792971+3826556930141001
ENST00000381577CD274chr95465606+ENST00000535193KDM4Cchr96792971+41468768633341082

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000381573ENST00000535193CD274chr95465606+KDM4Cchr96792971+0.0017863120.99821377
ENST00000381577ENST00000535193CD274chr95465606+KDM4Cchr96792971+0.0018170580.99818295

Top

Fusion Genomic Features for CD274-KDM4C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD274chr95465606+KDM4Cchr96792971+2.80E-101
CD274chr95465606+KDM4Cchr96792971+2.80E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for CD274-KDM4C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:5465606/chr9:6792971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD274chr9:5465606chr9:6792971ENST00000381573+4619_127149177.0DomainNote=Ig-like V-type
HgeneCD274chr9:5465606chr9:6792971ENST00000381577+57133_225263291.0DomainNote=Ig-like C2-type
HgeneCD274chr9:5465606chr9:6792971ENST00000381577+5719_127263291.0DomainNote=Ig-like V-type
HgeneCD274chr9:5465606chr9:6792971ENST00000381577+5719_238263291.0Topological domainExtracellular
HgeneCD274chr9:5465606chr9:6792971ENST00000381577+57239_259263291.0TransmembraneHelical
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021144_31001048.0DomainJmjC
TgeneKDM4Cchr9:5465606chr9:6792971ENST0000038130602116_5801048.0DomainJmjN
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021877_93401048.0DomainNote=Tudor 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021935_99101048.0DomainNote=Tudor 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022144_31001057.0DomainJmjC
TgeneKDM4Cchr9:5465606chr9:6792971ENST0000038130902216_5801057.0DomainJmjN
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022877_93401057.0DomainNote=Tudor 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022935_99101057.0DomainNote=Tudor 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018144_31016836.0DomainJmjC
TgeneKDM4Cchr9:5465606chr9:6792971ENST0000053519301816_5816836.0DomainJmjN
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018877_93416836.0DomainNote=Tudor 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018935_99116836.0DomainNote=Tudor 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018144_3100814.0DomainJmjC
TgeneKDM4Cchr9:5465606chr9:6792971ENST0000054377101816_580814.0DomainJmjN
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018877_9340814.0DomainNote=Tudor 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018935_9910814.0DomainNote=Tudor 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021689_74701048.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021752_78501048.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381306021808_86501048.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022689_74701057.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022752_78501057.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000381309022808_86501057.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018689_74716836.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018752_78516836.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000535193018808_86516836.0Zinc fingerPHD-type 2
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018689_7470814.0Zinc fingerNote=PHD-type 1
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018752_7850814.0Zinc fingerC2HC pre-PHD-type
TgeneKDM4Cchr9:5465606chr9:6792971ENST00000543771018808_8650814.0Zinc fingerPHD-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD274chr9:5465606chr9:6792971ENST00000381573+46133_225149177.0DomainNote=Ig-like C2-type
HgeneCD274chr9:5465606chr9:6792971ENST00000381573+4619_238149177.0Topological domainExtracellular
HgeneCD274chr9:5465606chr9:6792971ENST00000381573+46260_290149177.0Topological domainCytoplasmic
HgeneCD274chr9:5465606chr9:6792971ENST00000381577+57260_290263291.0Topological domainCytoplasmic
HgeneCD274chr9:5465606chr9:6792971ENST00000381573+46239_259149177.0TransmembraneHelical


Top

Fusion Gene Sequence for CD274-KDM4C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14432_14432_1_CD274-KDM4C_CD274_chr9_5465606_ENST00000381573_KDM4C_chr9_6792971_ENST00000535193_length(transcript)=3826nt_BP=556nt
GGCGCAACGCTGAGCAGCTGGCGCGTCCCGCGCGGCCCCAGTTCTGCGCAGCTTCCCGAGGCTCCGCACCAGCCGCGCTTCTGTCCGCCT
GCAGGGCATTCCAGAAAGATGAGGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCCCCATACAACAAAATCAAC
CAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATGAACTGACATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACA
AGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCACCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGA
ATCAACACAACAACTAATGAGATTTTCTACTGCACTTTTAGGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCCAGAA
CTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGGTAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATC
TTCCGTTTAAGAAAAGACACTGCCCTAACCATCATGGAGGTGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTC
AGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACCTTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTG
ATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGCTATGATGACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGG
CAGTCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAGCGATGACTGTGAAGGAGTTCAGGCAGCTGGCCAACAGTGGCAAATATTGT
ACTCCAAGATACTTGGATTACGAAGATTTGGAGCGCAAGTACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAAT
GGGAGCATATATGATGAGGGTGTGGATGAATGGAACATAGCTCGCCTCAATACAGTCTTGGATGTGGTTGAAGAAGAGTGTGGCATTTCT
ATTGAGGGTGTAAATACCCCATATCTCTATTTTGGCATGTGGAAGACCACGTTTGCATGGCACACCGAAGACATGGACCTCTATAGCATT
AATTATCTCCACTTTGGAGAGCCCAAGTCTTGGTATGCTATACCTCCGGAGCATGGAAAACGACTTGAAAGACTAGCTCAAGGTTTTTTC
CCAAGCAGCTCCCAAGGGTGTGATGCATTTCTTCGCCACAAGATGACATTGATTTCTCCATCAGTATTGAAGAAATATGGTATTCCCTTT
GACAAGATAACCCAGGAGGCTGGAGAATTCATGATCACTTTCCCATATGGCTACCATGCTGGTTTTAATCATGGTTTCAACTGTGCAGAA
TCTACAAATTTTGCTACTGTCAGATGGATTGACTATGGAAAAGTTGCCAAATTGTGCACTTGCAGGAAAGACATGGTGAAGATTTCAATG
GATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGCTTTGGAAACAAGGAAAGGATATATACACCATTGATCACACGAAGCCTACT
CCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGAGGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCCAGTGTGCTAGGTCTACC
TCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAGATGAAGTCGATGGGGCAGAGGTCCCTAACCCCGACTCAGTCACAGATGAC
CTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGAGGAACACAGAAGCATCTTCAGAAGAAGAGTCATCTGCTAGCAGGATGCAG
GTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAAACAGCTGCTTAAGTACATCTGTAACAGAAGACATAAAAACTGAGGATGAC
AAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTGAGGCTGATGATTCCATTCCATTGTCTAGTGGCTATGAGAAGCCCGAGAAA
TCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGTCATGCTCATCAGTGGCAGAGAGTAATGGTGTGTTAACAGAGGGAGAAGAG
AGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGGAAATCCCAGCGGTCCCCAGTGGAGAGAGAAATAGCTTCAAAGTCCCCAGT
ATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCCATCCACTTAGCAGGCCTCCAGCAAGATCTCCGATGACTCTTGTGAAGCAG
CAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCATTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGGCGAAACCTCTCATCCAC
CTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAGAGTATAATGCAACAGTGGCCAGGATGAAGCCACACTGTGCCATCTGCACT
CTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAGAAAATGATGCTAGATGGGAGACAAAATTAGATGAAGTCGTTACATCGGAG
GGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTTATAGTGAAGAAAATATAGAATATTCTCCACCCAATGCCTTCCTTGAAGAG
GATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCGTACGGGTTCATGCAAGTTGTTATGGTATTCCTTCTCATGAGATCTGTGAT
GGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAGCAGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTTAAGCAAACGAAG
AACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCCCAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAAATAGATGTAGGC
AGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAATCTAGACACAGCAACAGTAACAACAACAACAATAACAATGAAGGCTCACT
GTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCGCCACTGTTTCAGATGCTGTTTCTCATTCTCCATGGGAGCAGCCAGCATCG
TGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGAGTCAGACCCTGGACTTTCCCTTTTGTATCTGTCATTTTCCTCTGGATCCT
CACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGACTTCCTATGTGGGGTAAAATGACTTCCTTTGATTAATGTACTTTCTGTAT
CCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTGTCCTACTACAGCCTCAAAAATTGTCATTGGAATCAAAAGCTTTCCAAGGT
GCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTCCTGTAGCATGGAGGCATTATAATAGGAGTCTCAGAAGTTACACCATTTTT
CTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGAATCCACTCTATGTCTGTCAGCCTGAATCCTTCCTTCTTGCTGCACAACAA
AGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCACTCATTCATCAAAGTTCTATCTGGGTGATATATGCTATCGAAACAGATGTG
GACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTGAAGCTCATGTTATCACACATGCTGTGGGAAGAGAGGTCATTGGCATTCAA
GATGCAACACCTACAATATGGTGAATTAAAGATGCCATTTGCATGG

>14432_14432_1_CD274-KDM4C_CD274_chr9_5465606_ENST00000381573_KDM4C_chr9_6792971_ENST00000535193_length(amino acids)=1001AA_BP=1
MSSWRVPRGPSSAQLPEAPHQPRFCPPAGHSRKMRIFAVFIFMTYWHLLNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSD
HQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRL
RKDTALTIMEVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSG
LFTQYNIQKKAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEG
VNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKI
TQEAGEFMITFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPAS
TPEVKAWLQRRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQ
NLSDHIKLSGNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDV
ESHGNGLEPGEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQ
TKSPNFAAEQEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGT
SLLISCAKCCVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIP
LQRLKLGRLGI

--------------------------------------------------------------
>14432_14432_2_CD274-KDM4C_CD274_chr9_5465606_ENST00000381577_KDM4C_chr9_6792971_ENST00000535193_length(transcript)=4146nt_BP=876nt
GCGTCCCGCGCGGCCCCAGTTCTGCGCAGCTTCCCGAGGCTCCGCACCAGCCGCGCTTCTGTCCGCCTGCAGGGCATTCCAGAAAGATGA
GGATATTTGCTGTCTTTATATTCATGACCTACTGGCATTTGCTGAACGCATTTACTGTCACGGTTCCCAAGGACCTATATGTGGTAGAGT
ATGGTAGCAATATGACAATTGAATGCAAATTCCCAGTAGAAAAACAATTAGACCTGGCTGCACTAATTGTCTATTGGGAAATGGAGGATA
AGAACATTATTCAATTTGTGCATGGAGAGGAAGACCTGAAGGTTCAGCATAGTAGCTACAGACAGAGGGCCCGGCTGTTGAAGGACCAGC
TCTCCCTGGGAAATGCTGCACTTCAGATCACAGATGTGAAATTGCAGGATGCAGGGGTGTACCGCTGCATGATCAGCTATGGTGGTGCCG
ACTACAAGCGAATTACTGTGAAAGTCAATGCCCCATACAACAAAATCAACCAAAGAATTTTGGTTGTGGATCCAGTCACCTCTGAACATG
AACTGACATGTCAGGCTGAGGGCTACCCCAAGGCCGAAGTCATCTGGACAAGCAGTGACCATCAAGTCCTGAGTGGTAAGACCACCACCA
CCAATTCCAAGAGAGAGGAGAAGCTTTTCAATGTGACCAGCACACTGAGAATCAACACAACAACTAATGAGATTTTCTACTGCACTTTTA
GGAGATTAGATCCTGAGGAAAACCATACAGCTGAATTGGTCATCCCAGAACTACCTCTGGCACATCCTCCAAATGAAAGGACTCACTTGG
TAATTCTGGGAGCCATCTTATTATGCCTTGGTGTAGCACTGACATTCATCTTCCGTTTAAGAAAAGACACTGCCCTAACCATCATGGAGG
TGGCCGAGGTGGAAAGTCCTCTGAACCCCAGCTGTAAGATAATGACCTTCAGACCCTCCATGGAGGAGTTCCGGGAGTTCAACAAATACC
TTGCATACATGGAGTCTAAAGGAGCCCATCGTGCGGGTCTTGCAAAGGTGATTCCTCCTAAGGAGTGGAAGCCAAGACAGTGCTATGATG
ACATTGATAATTTGCTCATTCCAGCACCAATTCAGCAGATGGTCACAGGGCAGTCAGGACTGTTCACTCAGTACAACATCCAGAAAAAAG
CGATGACTGTGAAGGAGTTCAGGCAGCTGGCCAACAGTGGCAAATATTGTACTCCAAGATACTTGGATTACGAAGATTTGGAGCGCAAGT
ACTGGAAGAACTTAACTTTTGTGGCACCTATCTATGGTGCAGATATTAATGGGAGCATATATGATGAGGGTGTGGATGAATGGAACATAG
CTCGCCTCAATACAGTCTTGGATGTGGTTGAAGAAGAGTGTGGCATTTCTATTGAGGGTGTAAATACCCCATATCTCTATTTTGGCATGT
GGAAGACCACGTTTGCATGGCACACCGAAGACATGGACCTCTATAGCATTAATTATCTCCACTTTGGAGAGCCCAAGTCTTGGTATGCTA
TACCTCCGGAGCATGGAAAACGACTTGAAAGACTAGCTCAAGGTTTTTTCCCAAGCAGCTCCCAAGGGTGTGATGCATTTCTTCGCCACA
AGATGACATTGATTTCTCCATCAGTATTGAAGAAATATGGTATTCCCTTTGACAAGATAACCCAGGAGGCTGGAGAATTCATGATCACTT
TCCCATATGGCTACCATGCTGGTTTTAATCATGGTTTCAACTGTGCAGAATCTACAAATTTTGCTACTGTCAGATGGATTGACTATGGAA
AAGTTGCCAAATTGTGCACTTGCAGGAAAGACATGGTGAAGATTTCAATGGATATCTTTGTGAGGAAATTTCAGCCAGACAGATATCAGC
TTTGGAAACAAGGAAAGGATATATACACCATTGATCACACGAAGCCTACTCCAGCATCCACCCCTGAAGTAAAAGCATGGCTGCAGAGGA
GGAGGAAAGTAAGAAAAGCATCCCGAAGCTTCCAGTGTGCTAGGTCTACCTCTAAAAGGCCTAAGGCTGATGAGGAAGAGGAAGTGTCAG
ATGAAGTCGATGGGGCAGAGGTCCCTAACCCCGACTCAGTCACAGATGACCTCAAGGTCAGTGAAAAGTCAGAAGCAGCAGTGAAGCTGA
GGAACACAGAAGCATCTTCAGAAGAAGAGTCATCTGCTAGCAGGATGCAGGTGGAGCAGAATTTATCAGATCATATCAAACTCTCAGGAA
ACAGCTGCTTAAGTACATCTGTAACAGAAGACATAAAAACTGAGGATGACAAAGCTTATGCATATAGAAGTGTACCTTCTATATCCAGTG
AGGCTGATGATTCCATTCCATTGTCTAGTGGCTATGAGAAGCCCGAGAAATCAGACCCATCCGAGCTTTCATGGCCAAAGTCACCTGAGT
CATGCTCATCAGTGGCAGAGAGTAATGGTGTGTTAACAGAGGGAGAAGAGAGTGATGTGGAGAGCCATGGGAATGGCCTTGAACCTGGGG
AAATCCCAGCGGTCCCCAGTGGAGAGAGAAATAGCTTCAAAGTCCCCAGTATAGCAGAGGGAGAGAACAAAACCTCTAAGAGTTGGCGCC
ATCCACTTAGCAGGCCTCCAGCAAGATCTCCGATGACTCTTGTGAAGCAGCAGGCGCCAAGTGATGAAGAATTGCCTGAGGTTCTGTCCA
TTGAGGAGGAAGTGGAAGAAACAGAGTCTTGGGCGAAACCTCTCATCCACCTTTGGCAGACGAAGTCCCCTAACTTCGCAGCTGAGCAAG
AGTATAATGCAACAGTGGCCAGGATGAAGCCACACTGTGCCATCTGCACTCTGCTCATGCCGTACCACAAGCCAGATAGCAGCAATGAAG
AAAATGATGCTAGATGGGAGACAAAATTAGATGAAGTCGTTACATCGGAGGGAAAGACTAAGCCCCTCATACCAGAGATGTGTTTTATTT
ATAGTGAAGAAAATATAGAATATTCTCCACCCAATGCCTTCCTTGAAGAGGATGGAACAAGTCTCCTTATTTCCTGTGCAAAGTGCTGCG
TACGGGTTCATGCAAGTTGTTATGGTATTCCTTCTCATGAGATCTGTGATGGATGGCTGTGTGCCCGGTGCAAAAGAAATGCGTGGACAG
CAGAATGCTGTCTCTGCAATTTGAGAGGAGGTGCTCTTAAGCAAACGAAGAACAATAAGTGGGCCCATGTCATGTGCGCCGTTGCGGTCC
CAGAAGTTCGATTCACTAATGTCCCAGAAAGGACACAAATAGATGTAGGCAGAATACCTTTACAGAGGTTAAAATTGGGAAGGCTGGGAA
TCTAGACACAGCAACAGTAACAACAACAACAATAACAATGAAGGCTCACTGTGAAAACATCAATTCATTAGGAAAGTTACATCCCCTCCG
CCACTGTTTCAGATGCTGTTTCTCATTCTCCATGGGAGCAGCCAGCATCGTGTTTAGGATGGGGATACAATAGCCTGAGCTCCTGATTGA
GTCAGACCCTGGACTTTCCCTTTTGTATCTGTCATTTTCCTCTGGATCCTCACACCTTTGTGTTTAATTTTTTTAAATTTCATTTGTTGA
CTTCCTATGTGGGGTAAAATGACTTCCTTTGATTAATGTACTTTCTGTATCCTAGAGTTTCCCTTTCCCTTTGTGATTTAGTCCAACGTG
TCCTACTACAGCCTCAAAAATTGTCATTGGAATCAAAAGCTTTCCAAGGTGCATCAGGTTAATGATTTGGATGCATCCTGAGGTTGTCTC
CTGTAGCATGGAGGCATTATAATAGGAGTCTCAGAAGTTACACCATTTTTCTACAGCACATCACAGGCCCAGAGGCTTGAATCTAAGAGA
ATCCACTCTATGTCTGTCAGCCTGAATCCTTCCTTCTTGCTGCACAACAAAGCAACTGAACGTATTTTGAGTTTAGGTGAAAACTATCAC
TCATTCATCAAAGTTCTATCTGGGTGATATATGCTATCGAAACAGATGTGGACACTGGGCTGACAGATGTTGAGAACGGACCTGTTGCTG
AAGCTCATGTTATCACACATGCTGTGGGAAGAGAGGTCATTGGCATTCAAGATGCAACACCTACAATATGGTGAATTAAAGATGCCATTT
GCATGG

>14432_14432_2_CD274-KDM4C_CD274_chr9_5465606_ENST00000381577_KDM4C_chr9_6792971_ENST00000535193_length(amino acids)=1082AA_BP=0
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKD
QLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTT
TTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKDTALTIM
EVAEVESPLNPSCKIMTFRPSMEEFREFNKYLAYMESKGAHRAGLAKVIPPKEWKPRQCYDDIDNLLIPAPIQQMVTGQSGLFTQYNIQK
KAMTVKEFRQLANSGKYCTPRYLDYEDLERKYWKNLTFVAPIYGADINGSIYDEGVDEWNIARLNTVLDVVEEECGISIEGVNTPYLYFG
MWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAQGFFPSSSQGCDAFLRHKMTLISPSVLKKYGIPFDKITQEAGEFMI
TFPYGYHAGFNHGFNCAESTNFATVRWIDYGKVAKLCTCRKDMVKISMDIFVRKFQPDRYQLWKQGKDIYTIDHTKPTPASTPEVKAWLQ
RRRKVRKASRSFQCARSTSKRPKADEEEEVSDEVDGAEVPNPDSVTDDLKVSEKSEAAVKLRNTEASSEEESSASRMQVEQNLSDHIKLS
GNSCLSTSVTEDIKTEDDKAYAYRSVPSISSEADDSIPLSSGYEKPEKSDPSELSWPKSPESCSSVAESNGVLTEGEESDVESHGNGLEP
GEIPAVPSGERNSFKVPSIAEGENKTSKSWRHPLSRPPARSPMTLVKQQAPSDEELPEVLSIEEEVEETESWAKPLIHLWQTKSPNFAAE
QEYNATVARMKPHCAICTLLMPYHKPDSSNEENDARWETKLDEVVTSEGKTKPLIPEMCFIYSEENIEYSPPNAFLEEDGTSLLISCAKC
CVRVHASCYGIPSHEICDGWLCARCKRNAWTAECCLCNLRGGALKQTKNNKWAHVMCAVAVPEVRFTNVPERTQIDVGRIPLQRLKLGRL
GI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CD274-KDM4C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for CD274-KDM4C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for CD274-KDM4C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD274C0020517Hypersensitivity2CTD_human
HgeneCD274C1527304Allergic Reaction2CTD_human
HgeneCD274C0013146Drug abuse1CTD_human
HgeneCD274C0013170Drug habituation1CTD_human
HgeneCD274C0013222Drug Use Disorders1CTD_human
HgeneCD274C0024121Lung Neoplasms1CTD_human
HgeneCD274C0024299Lymphoma1CTD_human
HgeneCD274C0027666Neoplasms, Radiation-Induced1CTD_human
HgeneCD274C0029231Organic Mental Disorders, Substance-Induced1CTD_human
HgeneCD274C0038580Substance Dependence1CTD_human
HgeneCD274C0038586Substance Use Disorders1CTD_human
HgeneCD274C0235874Disease Exacerbation1CTD_human
HgeneCD274C0236969Substance-Related Disorders1CTD_human
HgeneCD274C0242379Malignant neoplasm of lung1CTD_human
HgeneCD274C0740858Substance abuse problem1CTD_human
HgeneCD274C0751366Radiation-Induced Cancer1CTD_human
HgeneCD274C0751552Malignant neoplasm of thymus1CTD_human
HgeneCD274C1510472Drug Dependence1CTD_human
HgeneCD274C2239176Liver carcinoma1CTD_human
HgeneCD274C3714644Thymus Neoplasms1CTD_human
HgeneCD274C4316881Prescription Drug Abuse1CTD_human
TgeneC0004565Melanoma, B161CTD_human
TgeneC0009075Melanoma, Cloudman S911CTD_human
TgeneC0018598Melanoma, Harding-Passey1CTD_human
TgeneC0025149Medulloblastoma1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0025205Melanoma, Experimental1CTD_human
TgeneC0079772T-Cell Lymphoma1CTD_human
TgeneC0205833Medullomyoblastoma1CTD_human
TgeneC0236663Alcohol withdrawal syndrome1PSYGENET
TgeneC0278510Childhood Medulloblastoma1CTD_human
TgeneC0278876Adult Medulloblastoma1CTD_human
TgeneC0751291Desmoplastic Medulloblastoma1CTD_human
TgeneC1275668Melanotic medulloblastoma1CTD_human